title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Investigations with infrared spectroscopy on films of the ionic liquid [EMIM]Tf2N. | The reflection-absorption infrared (RAIRS) spectra of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM]Tf 2N) are presented as a function of temperature between 114 and 292 K. A comparison is made with the corresponding infrared spectra (obtained with transmission spectroscopy) from bulk [EMIM]Tf 2N... | 18,798,600 |
X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. | Development of inhibitors specific for heme oxygenases (HOs) should aid our understanding of the HO system and facilitate future therapeutic applications. The crystal structure of human HO-1 complexed with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone (3) was determined. This inhibitor binds to the HO-1 distal pocket... | 18,798,608 |
Thermal C1-C5 diradical cyclization of enediynes. | Computational studies at the BLYP/6-31G(d) level (supplemented by BCCD(T)/cc-pVDZ calculations) suggest that in aryl-substituted 1,2-diethynylbenzenes, steric effects disfavor the thermal C1-C6 diradical cyclization reaction (Bergman) and electronic effects favor the regiovariant C1-C5 cyclization to the extent that th... | 18,798,628 |
A formal total synthesis of platencin. | The readily available and enantiomerically pure trienes 12 undergo a thermally induced intramolecular Diels-Alder reaction to give the corresponding mixture of compounds 13 and 14. This mixture has been elaborated to an advanced intermediate associated with Nicolaou's recently reported total synthesis of the natural en... | 18,798,641 |
Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. | mu-SIIIA, a novel mu-conotoxin from Conus striatus, appeared to be a selective blocker of tetrodotoxin-resistant sodium channels in frog preparations. It also exhibited potent analgesic activity in mice, although its selectivity profile against mammalian sodium channels remains unknown. We have determined the structure... | 18,798,648 |
Synthesis and characterization of diazonium functionalized nanoparticles for deposition on metal surfaces. | Silica nanoparticles were surface-functionalized with diazonium groups. The reaction steps leading to the formation of the diazonium functionality were followed with IR and XPS, and the structure of the diazonium-functionalized nanoparticle was confirmed with solid state NMR. Nanoparticle size distribution was determin... | 18,798,659 |
Novel biodegradable shape memory material based on partial inclusion complex formation between alpha-cyclodextrin and poly(epsilon-caprolactone). | A novel shape memory material was prepared based on the formation of inclusion complexes between alpha-cyclodextrin (alpha-CD) and poly(epsilon-caprolactone) (PCL); the PCL-alpha-CD inclusion crystallites serve as a fixing phase, while free PCL crystallites serve as a reversible phase. The characteristics of the materi... | 18,798,668 |
General, regiodefined access to alpha-substituted butenolides through metal-halogen exchange of 3-bromo-2-silyloxyfurans. Efficient synthesis of an anti-inflammatory gorgonian lipid. | A variety of alpha-substituted butenolides were efficiently prepared from 3-bromo-2-triisopropylsilyloxyfuran via lithium-bromine exchange and in situ quench with carbon or heteroatom electrophiles. The inherent flexibility of this methodology is illustrated by a short and efficient synthesis of an anti-inflammatory ma... | 18,798,671 |
Scanning tunneling microscopy images of alkane derivatives on graphite: role of electronic effects. | Scanning tunneling microscopy (STM) images of self-assembled monolayers of close-packed alkane chains on highly oriented pyrolitic graphite often display an alternating bright and dark spot pattern. Classical simulations suggest that a tilt of the alkane backbone is unstable and, therefore, unlikely to account for the ... | 18,798,685 |
Plasmon resonance in silver nanoparticles arrays grown by atomic terrace low-angle shadowing. | The plasmonic properties of aligned silver nanoparticles grown by atomic terrace low-angle shadowing (ATLAS) were studied by optical transmission spectroscopy. ATLAS is a novel nanofabrication technique that combines the advantages of self-assembly with control of the nanostructure features. The silver nanoarrays were ... | 18,798,686 |
Dose calculation of anticancer drugs. | Anticancer drugs are characterized by a narrow therapeutic window and significant inter-patient variability in therapeutic and toxic effects. Current body surface area (BSA)-based dosing fails to standardize systemic anticancer drug exposure and other alternative dosing strategies also have their limitations. Just as i... | 18,798,700 |
A review of telbivudine for the management of chronic hepatitis B virus infection. | Chronic hepatitis B is a worldwide health problem. Research interests have focused on the development of potent and safe antiviral agents with low resistance rates. Telbivudine is a nucleoside analogue that has been approved for treatment of chronic hepatitis B. This review article concentrates on the pharmacokinetics ... | 18,798,704 |
Role of vector control in the global program to eliminate lymphatic filariasis. | Lymphatic filariasis (LF) is a major cause of acute and chronic morbidity in the tropical and subtropical parts of the world. The availability of safe, single-dose, drug treatment regimens capable of suppressing microfilaremia to very low levels, along with improvements in techniques for diagnosing infection, has resul... | 18,798,707 |
Effects of bradykinin on venous capacitance in health and treated chronic heart failure. | In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=1... | 18,798,730 |
Protection afforded by sunscreens containing inorganic sunscreening agents against blue light sensitivity induced by aminolevulinic acid. | Application of aminolevulinic acid (ALA) for photodynamic therapy induces significant sensitivity to visible light. To determine whether sunscreens containing inorganic agents are effective against sensitivity to blue light induced by ALA application. Twenty subjects received application of ALA on the arm. Thirty minut... | 18,798,755 |
Efficacy and adverse effects of Q-switched ruby laser on solar lentigines: a prospective study of 91 patients with Fitzpatrick skin type II, III, and IV. | Laser-induced postinflammatory hyperpigmentation could be a limiting factor for selecting patients appropriate for the use of ruby laser in the treatment of lentigenes, especially in dark-skinned individuals. To evaluate the efficacy and adverse effects of Q-switched ruby laser light (694 nm) on solar lentigines in pat... | 18,798,756 |
Do different stakeholder groups share mental health research priorities? A four-arm Delphi study. | Despite considerable investment in research priority setting within diverse fields of healthcare, little is known about the extent to which different stakeholder groups share research priorities. Conflicting priorities may jeopardize stakeholder engagement in research. To identify the research priorities of different s... | 18,798,760 |
Common variable immunodeficiency: 20-yr experience at a single centre. | Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency. It can present at any age in patients with a history of recurrent bacterial infections, with or without a family history of other primary immunodeficiencies (PID), and shows a wide range of clinical manifestations and immun... | 18,798,799 |
CTG repeats at the myotonic protein kinase gene in a healthy Chilean population sample. | To study the variability at the myotonic dystrophy protein kinase (DMPK) gene in a Chilean sample of healthy people. DM1 is an autosomal dominant disorder caused by an expansion of a (CTG) repeat at the 3'-UTR of the gene DMPK. Healthy individuals have alleles under 35 repeats and diseased individuals have over 50. Gen... | 18,798,829 |
A distinct cellular profile is seen in the human endocervix during Chlamydia trachomatis infection. | The endocervix is a major target of Chlamydia trachomatis infection, but little is known about the immune repertoire in this tissue, or its response to these common bacteria. Using a cytobrush, we isolated cells from the endocervix of 20 women during C. trachomatis infection, and post-antibiotic treatment. Endocervical... | 18,798,835 |
New powerful approaches for family-based association tests with longitudinal measurements. | We discuss several new powerful family-based approaches for testing genetic association when the traits are obtained from longitudinal or repeated measurement studies. The popular approach FBAT-PC is based on a linear combination of the individual traits. We propose a one-sided modification, FBAT-PCM, which has a close... | 18,798,838 |
Skin cancer surveillance in renal transplant recipients: re-evaluation of U.K. practice and comparison with Australian experience. | Nonmelanoma skin cancer (NMSC) is the most common tumour following solid organ transplantation. In 2000 a survey of U.K. centres managing renal transplant recipients (RTRs) showed that only 21% offered skin cancer surveillance. The survey was repeated in 2006 in the U.K. and Australia. The aims were to determine if U.K... | 18,798,841 |
A clinical and genetic study of the Say/Barber/Biesecker/Young-Simpson type of Ohdo syndrome. | We report a series of eight patients with the Say/Barber/Biesecker/Young-Simpson (SBBYS) type of Ohdo syndrome, which is the largest cohort described to date. We expand on the type, frequency and severity of the clinical characteristics in this condition; comment on the natural history of Ohdo syndrome and further refi... | 18,798,845 |
Cerebral aspergillosis caused by Aspergillus ustus following orthotopic heart transplantation: case report and review of the literature. | This report describes the first case of cerebral aspergillosis in a heart transplantation patient caused by Aspergillus ustus and reviews 15 previously reported cases of invasive aspergillosis in immunocompromised hosts caused by this mold. The utility of molecular analysis for the identification of unusual fungal path... | 18,798,849 |
Cognitive distortions in child sex offenders: an overview of theory, research & practice. | A great deal of clinical and research attention has been paid to understanding and explaining child sex offenders' social cognition. Cognitive distortions have been implicated as a core feature of child sex offenders' offense supportive cognition. The primary aim of this paper is to critically evaluate the phenomenon o... | 18,798,877 |
Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study. | Neuregulin-1 proteins are related to physiological correlates of Type A in terms of cardiac reactivity. Furthermore, neuregulin-1 gene (NRG1) may play a role in cardiovascular disease such as atherosclerosis and coronary heart disease i.e. the suggested "outcomes" of Type A behavior. Therefore, NRG1 is hypothesized to ... | 18,798,975 |
Coining and defining novel nursing terminology. Part 1: critical incident nursing diagnosis. | In the first of a three-part series, a novel nursing terminology is introduced and proposed for inclusion in the North American Nursing Diagnosis Association (NANDA) International Classification--Critical incident nursing diagnosis (CIND)--defined as the recognition of an acute life-threatening event that occurs as a r... | 18,798,939 |
On the neural networks of empathy: A principal component analysis of an fMRI study. | Human emotional expressions serve an important communicatory role allowing the rapid transmission of valence information among individuals. We aimed at exploring the neural networks mediating the recognition of and empathy with human facial expressions of emotion. A principal component analysis was applied to event-rel... | 18,798,977 |
Passive tobacco exposure may impair symptomatic improvement in patients with chronic angina undergoing enhanced external counterpulsation. | The adverse effects of tobacco abuse on cardiovascular outcomes are well-known. However, the impact of passive smoke exposure on angina status and therapeutic response is less well-established. We examined the impact of second-hand smoke (SHS) exposure on symptomatic improvement in patients with chronic ischemic corona... | 18,798,998 |
Hope, despair and transformation: Climate change and the promotion of mental health and wellbeing. | This article aims to provide an introduction to emerging evidence and debate about the relationship between climate change and mental health. The authors argue that:i) the direct impacts of climate change such as extreme weather events will have significant mental health implications;ii) climate change is already impac... | 18,799,005 |
PCR diagnostics of Mycobacterium tuberculosis in historic human long bone remains from 18th century burials in Kaiserebersdorf, Austria. | In the present pilot study we applied recently published protocols for detecting Mycobacterium tuberculosis in human remains. We screened long bones from an 18th century cemetery and skulls from the anatomical "Weisbach collection" (19th century). In addition, besides the study of abundance of tuberculosis in inmates o... | 18,799,009 |
Onset of meiosis in the chicken embryo; evidence of a role for retinoic acid. | Meiosis in higher vertebrates shows a dramatic sexual dimorphism: germ cells enter meiosis and arrest at prophase I during embryogenesis in females, whereas in males they enter mitotic arrest during embryogenesis and enter meiosis only after birth. Here we report the molecular analysis of meiosis onset in the chicken m... | 18,799,012 |
Stress and psychological factors before a migraine attack: a time-based analysis. | The objective of this study is to examine the stress and mood changes of Japanese subjects over the 1-3 days before a migraine headache. The study participants were 16 patients with migraines who consented to participate in this study. Each subject kept a headache diary four times a day for two weeks. They evaluated th... | 18,799,013 |
Hydration status and physiological workload of UAE construction workers: A prospective longitudinal observational study. | The objective of the study was to investigate the physiological responses of construction workers labouring in thermally stressful environments in the UAE using Thermal Work Limit (TWL) as a method of environmental risk assessment. The study was undertaken in May 2006. Aural temperature, fluid intake, and urine specifi... | 18,799,015 |
[Role of high mobility group box 1 in adriamycin-induced apoptosis in leukemia K562 cells]. | High mobility group box l (HMGB1), a nuclear DNA-binding protein, stabilizes the structure and function of chromatin, regulates gene transcription. Recent studies found that HMGB1 is associated with the proliferation and metastasis of many tumors, including breast cancer, colon carcinoma, and melanoma, and is rich in v... | 18,799,030 |
[Impact of alpha1,2-fucosyl transferase gene transfection on cancer-related gene expression profile of human ovarian cancer cell line RMG-1]. | The malignant biological behaviors are enhanced in human ovarian cancer cell line RMG-1 after transfection of alpha1,2-fucosyl transferase (alpha1,2-FT) gene. This study was to investigate the influence of alpha1,2-FT gene transfection on cancer-related gene expression profile of RMG-1 cells. Gene expressing vector pcD... | 18,799,031 |
[Prognosis analysis of 83 cases of cervical adenosquamous carcinoma]. | Cervical adenosquamous carcinoma is a special histological type of cervical carcinoma. Its clinic-pathologic characteristics and prognostic factors have seldom been reported. This study was to explore the clinic-pathologic characteristics and prognostic factors of cervical adenosquamous carcinoma. Clinical data of 83 p... | 18,799,035 |
[Clinical analysis of 14 cases of urachal carcinoma]. | Urachal carcinoma is a rare malignancy. This study was to summarize our clinical experience in the diagnosis and treatment of urachal carcinoma. Fourteen cases of urachal carcinoma treated from May 1994 to April 2007 at Cancer Center and The First Affiliated Hospital of Sun Yat-sen University were retrospectively revie... | 18,799,037 |
Prevalence and impact of fibromyalgia on function and quality of life in individuals from the general population: results from a nationwide study in Spain. | To estimate the prevalence of fibromyalgia (FM) and to compare some descriptive epidemiological and quality of life data between persons with and without FM criteria in a representative sample of the general Spanish population. Cross sectional study of 2,192 Spaniards aged 20 or above, selected by cluster sampling. Sub... | 18,799,079 |
Diagnostic values of history and clinical examination to predict ultrasound signs of chronic and acute enthesitis. | To examine the diagnostic values of history of chronic enthesitic pain and clinical signs of acutely inflamed entheses to predict ultrasound (US) signs of enthesitis. Cohort study of 21 consecutive rheumatic out-patients (female/male 18/3) with suspected multiple enthesitis and 12 controls (female/male 10/2). 429 enthe... | 18,799,083 |
Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. | Pannus in osteoarthritis (OA) has only recently been characterized. Little is known, however, regarding the behavior of OA pannus in vitro compared to rheumatoid arthritis (RA) pannus. The purpose of our study was to compare OA with RA pannus. Pannus and synovial tissue co-cultures from 5 patients with OA and 5 patient... | 18,799,084 |
Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan). | Published scoring methods for quantifying synovitis focus on acute inflammatory parameters, and are unsuitable as outcome measures in experimental surgical models of osteoarthritis (OA). The aim of the present study was to define a modified histopathological scoring system for ovine synovium more suited to the chronic ... | 18,799,085 |
Serum levels of heat shock protein 70, a biomarker of cellular stress, are elevated in patients with systemic sclerosis: association with fibrosis and vascular damage. | To determine the clinical significance of heat shock protein (Hsp) 70, a sensitive biomarker for monitoring cellular stress, in systemic sclerosis (SSc), we investigated the prevalence and clinical correlation of serum Hsp70 levels in SSc patients. Serum Hsp70 levels were examined in 48 patients with SSc by enzyme-link... | 18,799,101 |
Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis. | To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA). Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in ... | 18,799,107 |
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. | A central focus of aging research is to determine how calorie restriction (CR) extends lifespan and delays diseases of aging. SIRT1, the mammalian ortholog of Sir2 in yeast, is a longevity factor which mediates dietary restriction in diverse species. In addition, SIRT1 plays a protective role in several models of neuro... | 18,799,131 |
TNF-alpha mediates pseudorabies virus-induced apoptosis via the activation of p38 MAPK and JNK/SAPK signaling. | PRV infection causes apoptosis in vitro and in vivo. However, the significance of PRV-induced apoptosis and its signaling pathways is still unknown. This work investigates the role of MAPK pathways in mediating PRV-induced apoptosis. Flow cytometry, apoptosis ELISA and western blotting using antibodies against cleaved ... | 18,799,179 |
Hepatobiliary effects of 90yttrium microsphere therapy for unresectable hepatocellular carcinoma. | (90)Yttrium (Therasphere) microspheres administered via hepatic artery are a valuable option for treatment of hepatocellular carcinoma. This therapy targets tumor nodules while largely sparing hepatic parenchyma. This retrospective study examines liver explants from 13 adult patients with hepatocellular carcinoma who r... | 18,799,190 |
The metastatic capacity of multifocal breast carcinomas: extensive tumors versus tumors of limited extent. | The extent and distribution of lesions in breast carcinomas are important morphologic prognostic parameters that influence the type and results of surgical intervention, as well as the propensity for metastasis. We investigated how the extent of disease influences the risk of metastasis in a consecutive series of 519 i... | 18,799,193 |
Clinical, pathological and thin-section CT features of persistent multiple ground-glass opacity nodules: comparison with solitary ground-glass opacity nodule. | To retrospectively compare the clinical, pathological, and thin-section CT features of persistent multiple ground-glass opacity (GGO) nodules with those of solitary GGO nodules. Histopathologic specimens were obtained from 193 GGO nodules in 136 patients (87 women, 49 men; mean age, 57; age range 33-81). The clinical d... | 18,799,230 |
Hospital outbreak of Burkholderia stabilis bacteraemia related to contaminated chlorhexidine in haematological malignancy patients with indwelling catheters. | Burkholderia cepacia complex (BCC) is an opportunistic pathogen that occasionally causes hospital outbreaks. This paper describes an outbreak of BCC bacteraemia in haematological malignancy patients related to a contaminated chlorhexidine gluconate solution. Eight BCC isolates were obtained from patients hospitalised i... | 18,799,235 |
Experience with the use of palivizumab together with infection control measures to prevent respiratory syncytial virus outbreaks in neonatal intensive care units. | Respiratory syncytial virus (RSV) frequently causes nosocomial outbreaks in general paediatric wards and occasionally in neonatal intensive care units (NICUs). Conventional infection control measures often fail to prevent the spread of RSV, and it can cause significant morbidity especially in preterm and young infants.... | 18,799,241 |
Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process. | The aim of this study is to propose a strategy to implement a PAT system in the blending step of pharmaceutical production processes. It was examined whether Raman spectroscopy can be used as PAT tool for the in-line and real-time endpoint monitoring and understanding of a powder blending process. A screening design wa... | 18,799,281 |
HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity. | HCV infection is well-known to be associated with autoimmune thyroiditis. However, the mechanisms by which HCV triggers thyroiditis are unknown. We hypothesized that HCV envelope proteins could induce thyroidal inflammation directly, thereby triggering thyroiditis by a bystander activation mechanism. To test this hypot... | 18,799,285 |
Characterisation and stability of lipid-DNA complexes. | A combination of complementary analytical techniques has provided valuable information on the physicochemical properties of lipid-DNA complexes such as their size, shape, structure and surface charge. The experimental conditions for producing small and stable lipid-DNA complexes were determined. These complexes consist... | 18,799,295 |
Structure and reactivity of a(n) and a(n) peptide fragments investigated using isotope labeling, tandem mass spectrometry, and density functional theory calculations. | Extensive (15)N labeling and multiple-stage tandem mass spectrometry were used to investigate the fragmentation pathways of the model peptide FGGFL during low-energy collision-induced-dissociation (CID) in an ion-trap mass spectrometer. Of particular interest was formation of a(4) from b(4) and a(4) (a(4)-NH(3)) from a... | 18,799,319 |
Bifurcating fragmentation behavior of gas-phase tryptic peptide dications in collisional activation. | Collision-activated dissociation (CAD) of tryptic peptides is a cornerstone of mass spectrometry-based proteomics research. Principal component analysis of a database containing 15,000 high-resolution CAD mass spectra of gas-phase tryptic peptide dications revealed that they fall into two classes with a good separation... | 18,799,320 |
Ion trap collision-induced dissociation of multiply deprotonated RNA: c/y-ions versus (a-B)/w-ions. | The dissociation of model RNA anions has been studied as a function of anion charge state and excitation amplitude using ion trap collisional activation. Similar to DNA anions, the precursor ion charge state of an RNA anion plays an important role in directing the preferred dissociation channels. Generally, the complem... | 18,799,321 |
The effect of the long head of the biceps on glenohumeral kinematics. | The long head of the biceps has been described as a stabilizing force in the setting of glenohumeral instability. However, data are lacking on the effect of loading the long head of the biceps on glenohumeral kinematics. Six cadaveric shoulders were tested for glenohumeral rotational range of motion and translation usi... | 18,799,325 |
Charcot-Marie-Tooth type 1a in a child with Long QT syndrome. | Charcot-Marie-Tooth disease (CMTD) is a hereditary demyelinating peripheral neuropathy clinically presenting with sensory and motor defects, but rarely affecting cardiac function. Long QT syndrome (LQTS) is a congenital or acquired cardiovascular disorder characterized by ventricular depolarization defect. No studies r... | 18,799,333 |
A microRNA expression ratio defining the invasive phenotype in bladder tumors. | The goal of this study was to identify a microRNA (miRNA) signature in bladder cancer capable of differentiating superficial from invasive disease. Expression profiling of 343 miRNAs was performed in a microarray format using noninvasive and invasive bladder carcinoma cell lines with differential expression confirmed u... | 18,799,331 |
High-flip-angle slice-selective parallel RF transmission with 8 channels at 7 T. | At high magnetic field, B(1)(+) non-uniformity causes undesired inhomogeneity in SNR and image contrast. Parallel RF transmission using tailored 3D k-space trajectory design has been shown to correct for this problem and produce highly uniform in-plane magnetization with good slice selection profile within a relatively... | 18,799,336 |
FT-IR spectroscopic investigation of ionic interactions in PPG 4000: AgCF3SO3 polymer electrolyte. | The effect of salt concentration on the ubiquitous ionic interactions observed in the case of the silver ion conducting polymer electrolyte system poly(propylene glycol) (PPG)-silver triflate has been investigated using Fourier transform infrared (FT-IR) spectroscopy as a probe for the characterization of the local env... | 18,799,349 |
Body mass index and quality of life: examining blacks and whites with chronic pain. | Obesity contributes to several chronic pain conditions, negatively affecting quality of life (QOL). However, obesity's relationship with chronic pain is poorly understood. This prospective survey study examines obesity's role in chronic pain and subsequent impact on QOL. Black and white patients with chronic pain (N = ... | 18,799,358 |
Prospective, randomized, pathologist-blinded study of disposable alligator-jaw biopsy forceps for gastric mucosal biopsy. | Endoscopic biopsy forceps differ in the size and shape of the biopsy cup and the presence or absence of a needle. We compared four different "large cup" forceps (three with needles) designed for 2.8mm biopsy channels. A gastric antral and corpus biopsy were obtained with each. Parameters examined included: weight (mg),... | 18,799,373 |
Inferior gluteal artery perforator flap: a viable alternative for ischial pressure sores. | The ischial area is by far the most common site for pressure sores in wheelchair-bound paraplegic patients, because most of the pressure of the body is exerted on this area in the seated position. Even after a series of successful pressure sore treatments, the site is very prone to relapse from the simplest everyday ta... | 18,799,379 |
[Metabolic imaging--PET, PET/CT--in oncologic surgery]. | The availability of PET/CT examinations in Hungary has significantly improved in the past few years. In the three Hungarian centres approximately 10,000 examinations can be performed yearly, which are financed by the national healthcare system. The PET/CT technique using FDG has become an efficient tumour diagnostic me... | 18,799,405 |
[Enterobius vermicularis causing symptoms of acute appendicitis]. | The authors present a case of enterobiasis of the appendix. Enterobius infection is an uncommon cause of acute appendicitis. Preoperative diagnosis of pinworm infestation is almost impossible unless there is a strong clinical suspicion. Parasites may produce symptoms which resemble acute appendicitis. Careful observati... | 18,799,410 |
Investigating children as cultural magnets: do young children transmit redundant information along diffusion chains? | The primary goal of this study was to investigate cultural transmission in young children, with specific reference to the phenomenon of overimitation. Diffusion chains were used to compare the imitation of 2- and 3-year-olds on a task in which the initial child in each chain performed a series of relevant and irrelevan... | 18,799,417 |
Blunted opiate modulation of hypothalamic-pituitary-adrenocortical activity in men and women who smoke. | To examine the extent to which nicotine dependence alters endogenous opioid regulation of the hypothalamic-pituitary-adrenocortical (HPA) axis functions. Endogenous opiates play an important role in regulating mood, pain, and drug reward. They also regulate the HPA functions. Previous work has demonstrated an abnormal ... | 18,799,426 |
Individual and neighborhood socioeconomic status characteristics and prevalence of metabolic syndrome: the Atherosclerosis Risk in Communities (ARIC) Study. | The objective of this study was to examine the association of individual socioeconomic status (iSES) and neighborhood SES (nSES) on the prevalence of metabolic syndrome (MetS) in the Atherosclerosis Risk in Communities Study (1987-1999). Participants included 2932 black and 9777 white men and women aged 45 to 64 years ... | 18,799,428 |
Outcomes in adults with bicuspid aortic valves. | Bicuspid aortic valve is the most common congenital cardiac anomaly in the adult population. Cardiac outcomes in a contemporary population of adults with bicuspid aortic valve have not been systematically determined. To determine the frequency and predictors of cardiac outcomes in a large consecutive series of adults w... | 18,799,444 |
Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo. | Urokinase-type plasminogen activator (uPA) plays a central role in tissue remodeling processes. Most of our understanding of the role of uPA in vivo is derived from studies using gene-targeted uPA-deficient mice. To enable in vivo studies on the specific interference with uPA functionality in mouse models, we have now ... | 18,799,467 |
Molecular and cellular adaptations to chronic myotendinous strain injury in mdx mice expressing a truncated dystrophin. | Myotendinous strain injury is the most common injury of human skeletal muscles because the majority of muscle forces are transmitted through this region. Although the immediate response to strain injury is well characterized, the chronic response to myotendinous strain injury is less clear. Here we examined the molecul... | 18,799,475 |
Identification of Arx transcriptional targets in the developing basal forebrain. | Mutations in the aristaless-related homeobox (ARX) gene are associated with multiple neurologic disorders in humans. Studies in mice indicate Arx plays a role in neuronal progenitor proliferation and development of the cerebral cortex, thalamus, hippocampus, striatum, and olfactory bulbs. Specific defects associated wi... | 18,799,476 |
Fewer partners or more condoms? Modelling the effectiveness of STI prevention interventions. | Some advocates of HIV prevention have counterposed programmes aimed at reducing numbers of sex partners to programmes aimed at increasing condom use. In this polarised debate, arguments about their relative effectiveness have been based on limited evidence. To explore the theoretical impact of changing partner acquisit... | 18,799,491 |
Interpreting declines in HIV prevalence: impact of spatial aggregation and migration on expected declines in prevalence. | Declines in the prevalence of HIV might occur due to natural epidemic dynamics rather than changes in risk behaviour. Determining the cause of an observed decline is important in understanding the epidemiology of HIV. To explore how patterns of recruitment and interactions between subpopulations in different areas infl... | 18,799,492 |
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. | During embryonic development, the establishment of the primitive erythroid lineage in the yolk sac is a temporally and spatially restricted program that defines the onset of hematopoiesis. In this report, we have used the embryonic stem cell differentiation system to investigate the regulation of primitive erythroid de... | 18,799,543 |
Crystal structure of the avian reovirus inner capsid protein sigmaA. | Avian reovirus, an important avian pathogen, expresses eight structural and four nonstructural proteins. The structural sigmaA protein is a major component of the inner capsid, clamping together lambdaA building blocks. sigmaA has also been implicated in the resistance of avian reovirus to the antiviral action of inter... | 18,799,570 |
Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. | Lens epithelium-derived growth factor (LEDGF)/p75 functions as a bimodal tether during lentiviral DNA integration: its C-terminal integrase-binding domain interacts with the viral preintegration complex, whereas the N-terminal PWWP domain can bind to cellular chromatin. The molecular basis for the integrase-LEDGF/p75 i... | 18,799,576 |
Baseline resistance of primary human immunodeficiency virus type 1 strains to the CXCR4 inhibitor AMD3100. | We screened a panel of R5X4 and X4 human immunodeficiency virus type 1 (HIV-1) strains for their sensitivities to AMD3100, a small-molecule CXCR4 antagonist that blocks HIV-1 infection via this coreceptor. While no longer under clinical development, AMD3100 is a useful tool with which to probe interactions between the ... | 18,799,588 |
Dynamic translation of surface coarseness into whisker vibrations. | Rodents in their natural environment use their whiskers to distinguish between surfaces having subtly different textures and shapes. They do so by actively sweeping their whiskers across surfaces in a rhythmic motion. To determine how textures are transformed into vibration signals in whiskers and how these vibrations ... | 18,799,602 |
Cardiolipin mediates cross-talk between mitochondria and the vacuole. | Cardiolipin (CL) is an anionic phospholipid with a dimeric structure predominantly localized in the mitochondrial inner membrane, where it is closely associated with mitochondrial function, biogenesis, and genome stability (Daum, 1985; Janitor and Subik, 1993; Jiang et al., 2000; Schlame et al., 2000; Zhong et al., 200... | 18,799,619 |
Health seeking for ambiguous symptoms in two cultural groups: a comparative study. | This study examined cultural differences in health seeking for medically ambiguous symptoms in women from two culturally diverse communities. Thirty-five South Asian immigrants and 36 European Americans participated in a health history interview. Though the types and relative frequencies of practices were similar acros... | 18,799,641 |
Evaluation of a commercial Echinococcus Western Blot assay for serological follow-up of patients with alveolar echinococcosis. | A total of 20 patients with alveolar echinococcosis in different clinical stages according to the WHO-PNM staging system (P, parasitic mass in the liver; N, involvement of neighboring organs; M, metastasis) were followed up serologically with the commercial Echinococcus Western Blot IgG assay and a crude antigen extrac... | 18,799,646 |
Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. | Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide. Regulation of aqueous humor drainage through the TM, however, is poorly understood. The role of RhoA GTPase-mediated actomyos... | 18,799,648 |
Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling. | The actin cytoskeleton regulates exocytosis in all secretory cells. In neutrophils, Rac2 GTPase has been shown to control primary (azurophilic) granule exocytosis. In this report, we propose that Rac2 is required for actin cytoskeletal remodeling to promote primary granule exocytosis. Treatment of neutrophils with low ... | 18,799,653 |
A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine. | Stilbenes are considered the most important phytoalexin group in grapevine (Vitis vinifera) and they are known to contribute to the protection against various pathogens. The main stilbenes in grapevine are resveratrol and its derivatives and, among these, pterostilbene has recently attracted much attention due both to ... | 18,799,660 |
Fidelity of complex spike-mediated synaptic transmission between inhibitory interneurons. | Complex spikes are high-frequency bursts of Na+ spikes, often riding on a slower Ca2+-dependent waveform. Although complex spikes may propagate into axons, given their unusual shape it is not clear how reliably these bursts reach nerve terminals, whether their spikes are efficiently transmitted as a cluster of postsyna... | 18,799,676 |
Growth of white matter in the adolescent brain: role of testosterone and androgen receptor. | The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample ... | 18,799,683 |
Sympathetic activation in chronic renal failure. | The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease... | 18,799,718 |
FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging. | Stress or aging of tissue-specific stem cells is considered central to the decline of tissue homeostasis in the elderly, although little is known of molecular mechanisms underlying hematopoietic stem cell (HSC) aging and stress resistance. Here, we report that mice lacking the transcription factor forkhead box O3a (Fox... | 18,799,725 |
Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function. | Down-regulation of the forkhead transcription factor Foxp1 by integrin engagement controls monocyte differentiation in vitro. To determine whether Foxp1 plays a critical role in monocyte differentiation and macrophage functions in vivo, we generated transgenic mice (macFoxp1tg) overexpressing human FOXP1 in monocyte/ma... | 18,799,727 |
Bill Kane passionate practitioner. | William "Bill" M. Kane, PhD, CHES. William "Bill" M. Kane, PhD, CHES, was a man with public health credentials that could impress just about anyone. He served as executive director of both the American College of Preventive Medicine and the Association for the Advancement of Health Education. He was a professor of heal... | 18,799,766 |
Neighborhoods and obesity in later life. | We examined the influence of neighborhood environment on the weight status of adults 55 years and older. We conducted a 2-level logistic regression analysis of data from the 2002 wave of the Health and Retirement Study. We included 8 neighborhood scales: economic advantage, economic disadvantage, air pollution, crime a... | 18,799,770 |
Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat. | Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) are important phase II enzymes involved in the biotransformation of xenobiotics. In toxicity and carcinogenicity studies, functional polymorphism of rat N-acetyltransferase is considered a model for similar human variability. To accurately quantitate expression of the thr... | 18,799,802 |
Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. | Secondary metabolites of Solanaceae plants, sharing tropane skeleton as a common structural feature, are sharply divided into two classes: tropine and ecgonine derivatives. The first group, represented by well known alkaloids: atropine and scopolamine, which are considered to be model anticholinergic drugs, continues t... | 18,799,813 |
CPU0213, a novel endothelin receptor antagonist, suppresses the upregulation of matrix metalloproteinases and connexin 43 in hyperthyroid myocardium. | It has been verified that endothelin-1 (ET-1) activates matrix metalloproteinase (MMP) in the process of myocardial remodeling. Sustained high thyroid hormone level gives rise to left ventricular hypertrophy, in which the ET-1 system is probably involved.We attempted to study the effects of CPU0213, a novel endothelin ... | 18,799,821 |
Serum and intraerythrocyte antioxidant enzymes and lipid peroxides in children with migraine. | The oxidant-antioxidant balance disorders underlie a number of acute and chronic diseases of the central nervous system (CNS). It is believed that oxidative stress plays a role in the pathogenesis of migraine. The study objective was to assess the processes of lipid peroxidation with malondialdehyde (MDA) as its major ... | 18,799,823 |
Energy-resolved computed tomography: first experimental results. | First experimental results with energy-resolved computed tomography (CT) are reported. The contrast-to-noise ratio (CNR) in CT has been improved with x-ray energy weighting for the first time. Further, x-ray energy weighting improved the CNR in material decomposition CT when applied to CT projections prior to dual-ener... | 18,799,830 |
Optically stimulated luminescence (OSL) dosimetry in medicine. | This paper reviews fundamental and practical aspects of optically stimulated luminescence (OSL) dosimetry pertaining to applications in medicine, having particularly in mind new researchers and medical physicists interested in gaining familiarity with the field. A basic phenomenological model for OSL is presented and t... | 18,799,833 |
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