title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Polymorphism of urea-barbituric acid co-crystals. | The crystal structures of three polymorphs found for the addition complex of urea and barbituric acid are described and compared. Two polymorphs are monoclinic, space groups P2(1)/c and Cc, whereas the third is triclinic, P1. The displacement of electron density towards the mesomeric forms, corresponding to the tautome... | 18,799,850 |
Patella malalignment syndrome: rationale to reduce excessive lateral pressure. | Patella malalignment syndrome is characterized by pain in the anterior portion of the knee. There can be numerous causes; however, the end result appears to be excessive lateral pressure on the patellofemoral articulation. This problem commonly affects athletes as an overuse injury. Standard conservative treatment atte... | 18,799,862 |
Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms. | Impaired homocysteine metabolism is associated with a number of vasculopathies including extracranial aneurysms. We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms. Caucasian patients (n = 255) treated at two German hospitals for intrac... | 18,799,873 |
Brain natriuretic peptide as a surrogate marker for cardioembolic stroke with paroxysmal atrial fibrillation. | Cardioembolic stroke generally results in severer disability, since it typically has a larger ischemic area than the other types of ischemic stroke. However, it is difficult to differentiate cardioembolic from noncardioembolic stroke (atherothrombotic and lacunar stroke), whenever ischemic stroke patients have sinus rh... | 18,799,875 |
Photodynamic therapy for granuloma annulare: more than a shot in the dark. | Granuloma annulare (GA) is a benign granulomatous and inflammatory skin disorder. The pathogenesis remains enigmatic and convincingly effective treatment options are not available. Inspired by a report showing photodynamic therapy (PDT) to be effective in a single patient with GA, we sought to evaluate this benefit in ... | 18,799,877 |
Cutaneous aseptic neutrophilic abscesses and Yersinia enterocolitica infection in a case subsequently diagnosed as Crohn's disease. | We report the case of a man who presented cutaneous aseptic abscesses, a rare form of neutrophilic disease, associated with Yersinia enterocolitica infection and who was later diagnosed as having Crohn's disease (CD). Genetic analysis showed that the patient had a mutation in the caspase activation recruitment domain 1... | 18,799,880 |
Anti-IgE for the treatment of allergic rhinitis--and eventually nasal polyps? | In allergic rhinitis, cross-linking of IgE molecules upon allergen contact induces degranulation of mast cells and basophils within the mucosal tissue and results in the release of typical mediators, which consecutively induce the well-known symptoms. Omalizumab counteracts these interactions by reducing serum levels o... | 18,799,888 |
Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders. | Alpha-synuclein (alpha-Syn) is a neuronal protein involved in the regulation of brain serotonin and dopamine levels. We analyzed the peripheral expression of alpha-Syn mRNA and Beck Depression Inventory scores in female patients suffering from anorexia nervosa (n = 18) or bulimia nervosa (n = 24). We found a significan... | 18,799,894 |
[Adjuvant epirubicin and cyclophosphamide followed by weekly paclitaxel for Japanese women with node-positive breast cancer: a multi-institutional feasibility study]. | We evaluated the feasibility of epirubicin plus cyclophosphamide(EC)followed by weekly paclitaxel (wPTX) as an adjuvant therapy for node-positive breast cancer in a variety of practice settings. Thirty-two patients received EC (twenty-two: 75, 600 mg/m(2), ten: 90, 600 mg/m(2))every 3 weeks for 4 cycles. Twenty-eight o... | 18,799,904 |
[Neoadjuvant chemotherapy followed by radical surgery compared to concurrent chemotherapy in stage I b2- III b cervical cancer]. | For the treatment of bulky cervical cancer, the most promising modality is surgery followed neoadjuvant chemotherapy( NAC-S)or concurrent chemoradiation therapy (CCRT). The purpose of this study is to compare the efficacy and complications associated with each treatment. The CCRT group included significantly more elder... | 18,799,907 |
[A case of advanced gastric cancer with giant lymph node metastasis responding to S-1/CDDP neoadjuvant chemotherapy]. | The patient was a 66-year-old man with advanced gastric cancer and bulky lymph node metastases. Since a radical resection appeared impossible, we tried neoadjuvant chemotherapy (NAC) with S-1/CDDP, expecting down staging of the tumor. S-1 (120 mg/body) was orally administered for 21 days and CDDP (40 mg/body) was admin... | 18,799,914 |
[Case report of gastric cancer patient who suffered life-threatening adverse events including severe myelosuppression during neoadjuvant chemotherapy with S-1 and CDDP combination]. | Neoadjuvant chemotherapy has been a recent focus in the treatment for advanced gastric cancer. Although the preoperative chemotherapeutic regimen of S-1 and CDDP is regarded as effective, safe and well tolerable according to previous clinical study, we experienced a 74-year-old woman who suffered from life-threatening ... | 18,799,915 |
[Three cases with liver metastasis from gastric or colon cancer successfully treated with S-1 combined with CPT- 11]. | We report three cases with liver metastasis from gastric or colon cancer successfully treated with S-1 with CPT-11. Case 1: A total gastrectomy was performed for a gastric cancer located in the lower to upper body of the stomach (T3 (SE), N2, H0, P0, por 2, stage III B). Abdominal computed-tomography (CT) revealed a so... | 18,799,916 |
[A case of advanced accessory breast cancer effectively treated with trastuzumab and paclitaxel]. | A 53-year-old woman was admitted for left axillary mass. The computed tomography showed an invasive mass in the left axilla and left supraclavicular lymph node swelling. Histological findings of axillary mass revealed infiltrating ductal carcinoma of scirrhous type. We diagnosed advanced accessory breast cancer, and th... | 18,799,924 |
[The role of gemtuzumab ozogamicin in the treatment of acute myeloid leukemia patients]. | Gemtuzumab Ozogamicin (GO) targets leukemia cells expressing CD33 by means of a monoclonal antibody conjugated to a cytotoxic agent, calicheamicin. GO has been approved in Japan as monotherapy for the treatment of patients with relapsed/refractory acute myeloid leukemia (AML)since 2005. GO administered as a single agen... | 18,799,927 |
Microbial subversion of heparan sulfate proteoglycans. | The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment a... | 18,799,929 |
Longevity genes: insights from calorie restriction and genetic longevity models. | In this review, we discuss the genes and the related signal pathways that regulate aging and longevity by reviewing recent findings of genetic longevity models in rodents in reference to findings with lower organisms. We also paid special attention to the genes and signals mediating the effects of calorie restriction (... | 18,799,928 |
Postural changes in blood pressure in the general population of Cantabria (northern Spain). | To describe the postural changes in blood pressure and correlates among the general population of Cantabria, a region in the north of Spain. Between 2002 and 2004 blood pressure measurements were taken in a seated position and after 1 and 3 min standing on a random sample of 1178 individuals aged 18 years and above, st... | 18,799,951 |
Noninvasive assessment of coronary anatomy and myocardial perfusion: going toward an integrated imaging approach. | Many noninvasive imaging techniques are available for the evaluation of patients with known or suspected chronic coronary artery disease. Among these, computed tomography-based techniques allow the quantification of coronary atherosclerotic calcium and noninvasive imaging of coronary arteries, whereas nuclear cardiolog... | 18,799,959 |
Marital status and cardiac rehabilitation attendance: a meta-analysis. | Marital status has been clearly linked to subsequent health outcomes in those with established coronary heart disease (CHD). This robust association may be because of both pathophysiological and behavioural mechanisms. We employed meta-regression to examine the association between marital status and attendance at outpa... | 18,800,004 |
Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury. | Intracerebral injection of ibotenate in newborn rodents produces brain damage that mimics that of infants with cerebral palsy. Because maternal infection may contribute to brain injury in preterm infants, we investigated brain damage after maternal inflammation and postnatal ibotenate treatment in a rat model of cerebr... | 18,800,008 |
A rat model of chronic kidney disease-mineral bone disorder. | Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slo... | 18,800,026 |
Sensing necrosis with Mincle. | The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process. | 18,800,160 |
Tuberculosis: unsealing the apoptotic envelope. | Mycobacterium tuberculosis grows in macrophages but escapes these cells by triggering their death. New findings delineate how this pathogen controls macrophage death to favor bacterial survival and avoid host immunity. | 18,800,161 |
Amyloid oligomer conformation in a group of natively folded proteins. | Recent in vitro and in vivo studies suggest that destabilized proteins with defective folding induce aggregation and toxicity in protein-misfolding diseases. One such unstable protein state is called amyloid oligomer, a precursor of fully aggregated forms of amyloid. Detection of various amyloid oligomers with A11, an ... | 18,800,165 |
Imaging mass spectrometry technology and application on ganglioside study; visualization of age-dependent accumulation of C20-ganglioside molecular species in the mouse hippocampus. | Gangliosides are particularly abundant in the central nervous system (CNS) and thought to play important roles in memory formation, neuritogenesis, synaptic transmission, and other neural functions. Although several molecular species of gangliosides have been characterized and their individual functions elucidated, the... | 18,800,170 |
Kernel stick-breaking processes. | We propose a class of kernel stick-breaking processes for uncountable collections of dependent random probability measures. The process is constructed by first introducing an infinite sequence of random locations. Independent random probability measures and beta-distributed random weights are assigned to each location.... | 18,800,173 |
Diversity of microbial communities in open mixed culture fermentations: impact of the pH and carbon source. | Anaerobic fermentation by an open mixed culture was investigated at different pH values (4-8.5) and with three substrates (glucose, glycerol and xylose). The populations established in each condition were assessed by denaturing gradient gel electrophoresis analysis of the 16S ribosomal RNA gene fragments. The fermentat... | 18,800,185 |
Mercury dispersal to arroyo and coastal sediments from abandoned copper mine operations, el Boléo, Baja California. | Evidence for mercury dispersal in an arid coastal region of central Baja California (Mexico) suggests that abandoned copper mining operations are a noticeable source of mercury in the environment. There is a generally elevated level of mercury in alluvium of arroyos throughout the mining district (0.14-0.18 mg kg(-1)).... | 18,800,200 |
Lincomycin and spectinomycin concentrations in liquid swine manure and their persistence during simulated manure storage. | Antimicrobials administered to livestock can be excreted up to 75% in the feces and urine. Liquid swine manure from confined animal feeding operations is generally retained in lagoon storage until it is applied as a nutrient source to crop and pasture land. Thus, the applied manure becomes a possible source of antimicr... | 18,800,201 |
Genetic polymorphisms in venous thrombosis and pulmonary embolism after total hip arthroplasty: a pilot study. | Deep venous thrombosis (DVT) after major orthopaedic surgery is a substantial concern. We asked whether the single or combined presence of thrombophilic genetic polymorphisms might further increase the already high risk for venous thrombosis and pulmonary embolism (PE) after THA. We therefore compared the prevalence of... | 18,800,213 |
Tyrosine phosphorylation of plant tubulin. | Phosphorylation of alphabeta-tubulins dimers by protein tyrosine kinases plays an important role in the regulation of cellular growth and differentiation in animal cells. In plants, however, the role of tubulin tyrosine phosphorylation is unknown and data on this tubulin modification are limited. In this study, we used... | 18,800,224 |
Neutral invertases in grapevine and comparative analysis with Arabidopsis, poplar and rice. | Neutral invertases (NIs, EC 3.2.1.26) cleave sucrose to glucose and fructose. They are encoded by a small gene family of 9 members in the Arabidopsis genome, 8 in rice, 16 in poplar and 9 in Vitis vinifera (L.). The grapevine NIs were identified in the 8.4X genome assembly of the quasi-homozygous line PN40024. In addit... | 18,800,225 |
Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells. | In addition to the activity of heat shock protein 90 (Hsp90/HSPC) as a chaperone, some recent studies have reported expression of Hsp90 at the cell surface in certain types of cancer and nervous system cells. We study the expression of Hsp90 at the cell surface in human neuroblastoma (NB69) cells. Immunofluorescence ex... | 18,800,240 |
Spray pattern and droplet size analyses for high-shear viscosity determination of aqueous suspension corticosteroid nasal sprays. | Aqueous suspension corticosteroid nasal sprays exhibit the rheological property of shear thinning, meaning they exhibit a decrease in viscosity upon application of shear. Most rheological methods are limited in the amount of shear that can be applied to samples (approximately 1,000 s(-1)) and thus can only approximate ... | 18,800,252 |
Protease-catalyzed synthesis of a precursor dipeptide, Z-Asp-Val-NH2 of thymopentin, in organic solvents. | The protease-catalyzed, kinetically controlled synthesis of a precursor dipeptide, Z-Asp-Val-NH(2) of thymopentin (TP-5), in organic solvents was studied. Z-Asp-OMe and Val-NH(2) were used as the acyl donor and the nucleophile, respectively. An industrial alkaline protease alcalase was used to catalyze the synthesis of... | 18,800,297 |
Ni2+-based immobilized metal ion affinity chromatography of lactose operon repressor protein from Escherichia coli. | A two-step chromatographic sequence is described for the purification of native lactose operon repressor protein from Escherichia coli cells. The first step involves Ni(2+)-based immobilized metal ion affinity chromatography of the soluble cytoplasmic extract. This method provides superior speed, resolution and yield t... | 18,800,304 |
Development and validation of an on-line two-dimensional reversed-phase liquid chromatography-tandem mass spectrometry method for the simultaneous determination of prostaglandins E(2) and F(2alpha) and 13,14-dihydro-15-keto prostaglandin F(2alpha) levels in human plasma. | We developed and validated an on-line reverse-phase two-dimensional LC/MS/MS (2D-LC/MS/MS) system for simultaneous determination of the levels of prostaglandin (PG) E(2) as well as PGF(2alpha) and its metabolite 13,14-dihydro-15-keto PGF(2alpha) (F(2alpha)-M) in human plasma. Analytes were extracted by a three-step sol... | 18,800,333 |
Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide. | The discovery of acrylamide (AA) in a variety of fried foods has raised public health concerns. In this study, groups of male mice were administered 500 mg/L AA in drinking water for 3 weeks, and gene expression changes were evaluated in the livers of AA-treated mice within 24 hr of the last treatment. When a two-fold ... | 18,800,343 |
K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3'-azido-3'-deoxythymidine. | A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinoma... | 18,800,350 |
The FOOTSTEP self-management foot care programme: are rheumatoid arthritis patients physically able to participate? | The FOOTSTEP self-management foot care programme is a clinical and cost-effective programme for basic foot care in the elderly. The aim of this study was to determine if patients with rheumatoid arthritis (RA) would be physically able to participate. A consecutive cohort of RA patients undergoing podiatry care underwen... | 18,800,356 |
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation? | The aging process involves changes in immune regulation, i.e. adaptive immunity declines whereas innate immunity becomes activated. NF-kappaB signaling is the master regulator of the both immune systems. Two recent articles highlight the role of the NF-kappaB system in aging and immune responses. Adler et al showed tha... | 18,800,364 |
Fluorescence quenching and bonding properties of some hydroxamic acid derivatives by iron(III) and manganese(II). | Spectrophotometric investigations of highly fluorescent metal chelating molecules are of relevance due to their potential application in novel, selective fluorescence-based sensors. Benzene and naphthalene chromophores are highly fluorescent while hydroxamic acids are widely used as ligands for complexation of transiti... | 18,800,360 |
Decorin and its galactosaminoglycan chain: extracellular regulator of cellular function? | A molecular network of extracellular matrix molecules determines the tissue architecture and accounts for mechanical properties like compressibility or stretch resistance. It is widely accepted that the elements of the cellular microenvironment are important regulators of the cellular behavior in vitro and in vivo. One... | 18,800,386 |
[A 68-year-old woman with iron deficiency anemia]. | A 68-year-old woman with iron deficiency anemia (due to gastrointestinal bleeding) was evaluated. Over a period of two years she received iron supplementation perorally and intravenously, as well as multiple blood transfusions, but the hemoglobin level did not exceed 10 g/dL. The investigations included upper endoscopy... | 18,800,392 |
Pharmacology of losartan, an angiotensin II receptor antagonist, in animal models of hypertension. | Clinical experience with angiotensin converting enzyme (ACE) inhibitors has shown that inhibition of the renin-angiotensin system is effective therapy for hypertension and heart failure. Losartan (DuP753, MK954, cozaar) is the first non-peptidic drug that inhibits the renin-angiotensin system by selectively blocking th... | 18,800,451 |
Influence of Asian and Western United States urban areas and fires on the atmospheric transport of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and fluorotelomer alcohols in the Western United States. | Atmospheric measurements of semivolatile organic compounds (SOCs) were made at Mt Bachelor Observatory (MBO), located in Oregon's Cascade Range, to understand the trans-Pacific and regional transport of SOCs from urban areas. High volume air sampling (approximately 644 m3 for 24 h periods) of both the gas and particula... | 18,800,505 |
Isomer-specific degradation and endocrine disrupting activity of nonylphenols. | Degradation of technical nonylphenol by Sphingobium xenophagum Bayram led to a significant shift in the isomers composition of the mixture. By means of gas chromatography-mass spectrometry, we could observe a strong correlation between transformation of individual isomers and their alpha-substitution pattern, as expres... | 18,800,507 |
Evaluating regional patterns in nitrate sources to watersheds in National Parks of the Rocky Mountains using nitrate isotopes. | In the Rocky Mountains, there is uncertainty about the source areas and emission types that contribute to nitrate (NO3) deposition, which can adversely affect sensitive aquatic habitats of high-elevation watersheds. Regional patterns in NO3 deposition sources were evaluated using NO3 isotopes in five National Parks, in... | 18,800,519 |
Occurrence and sources of perfluorinated surfactants in rivers in Japan. | We analyzed perfluorinated surfactants (PFSs) in 20 river samples and 5 wastewater secondary effluent samples in Japan to reveal their occurrence and sources. Nine PFS species were determined: perfluorooctanesulfonate (PFOS), perfluorooctane sulfonamide (FOSA), perfluoroheptanoate (PFHpA), perfluorooctanoate (PFOA), pe... | 18,800,531 |
Size-resolved source apportionment of airborne particle mass in a roadside environment. | Airborne particulate hopanes, steranes, and polycyclic aromatic hydrocarbons (PAHs) were measured in six size fractions < 1.8 microm particle diameter at one site upwind and two sites downwind of the Interstate 5 freeway in San Diego, CA. The smallest size fraction collected was exclusively in the ultrafine size ran... | 18,800,533 |
Phosphate adsorption by fresh and aged aluminum hydroxide. Consequences for lake restoration. | Lake restoration by in-lake precipitation of PO4(3-) with Al(OH)3 is commonly used but there is currently no good guidelines for calculating doses (amounts and application) that can ensure long lasting effects. We studied the effect of aging of Al(OH)3 on PO4(3-) adsorption and desorption properties with and without PO... | 18,800,544 |
Photocatalytic degradation of toluene in the gas phase: relationship between surface species and catalyst features. | Photocatalytic activity of both commercial and homemade samples was tested for the degradation of toluene in the gas phase by using two different irradiation sources, UV and solar. The role played by humidity in affecting the final toluene degradation was discussed. Catalyst deactivation (due to the high toluene level,... | 18,800,547 |
Mercury oxidation in flue gas using gold and palladium catalysts on fabric filters. | The feasibility of oxidizing elemental mercury in coal combustion flue gas using catalytic material impregnated onto fabric filters was explored. TiO2, Au/TiO2, and Pd/Al2O3 were studied based on promising results in previous research. Several fabric coating methods were investigated to determine the best way to load a... | 18,800,548 |
Is sustainability achievable? Exploring the limits of sustainability with model systems. | Successful implementation of sustainability ideas in ecosystem management requires a basic understanding of the often nonlinear and nonintuitive relationships among different dimensions of sustainability, particularly the system-wide implications of human actions. This basic understanding further includes a sense of th... | 18,800,553 |
[Cervical biopsy: is the histological diagnosis reliable and reproducible? Utility of p16 INK4A in its achievement]. | Cervical biopsy is the gold standard method used for diagnosing cervical intraepithelial neoplasia, however, it has being stated a very low diagnostic agreement. Klaes demonstrates that p16 immunohistochemical marker increases from 40 to 97% the diagnostic agreement in cervical intraepithelial neoplasia; due to it, its... | 18,800,580 |
[Brief version (15 items) of the General Health Questionnaire for opportune detection of psychological uneasiness in women]. | To propose a short version of the Goldberg's General Health Questionnaire that can be applied as a screening test in non-specialized in mental health public institutions. Women older than 18 years from Instituto Nacional de Perinatología consult. General Health Questionnaire application (30 items), during nine consecut... | 18,800,587 |
Microbial lipases: at the interface of aqueous and non-aqueous media. A review. | In recent times, biotechnological applications of microbial lipases in synthesis of many organic molecules have rapidly increased in non-aqueous media. Microbial lipases are the 'working horses' in biocatalysis and have been extensively studied when their exceptionally high stability in non-aqueous media has been disco... | 18,800,594 |
[Cyclic thrombocytopenia complicated with Sjögren syndrome and the mechanism of periodic platelet count fluctuation]. | Cyclic thrombocytopenia is a rare disorder with periodic changes of the platelet count. We experienced a patient with cyclic thrombocytopenia and Sjögren syndrome (SS), and studied the mechanism of the cyclic changes of the platelet count. The patient, a 75-year-old woman, was referred to our hospital because of dry mo... | 18,800,616 |
[Case of symptomatic epilepsy presenting with focal high intensity on diffusion-weighted image prior to initial convulsive seizure]. | It has been reported that high intensity on diffusion-weighted image (DWI) in magnetic reasonance imaging (MRI) accompanying a reduction of the apparent diffusion coefficient (ADC) can be detected at the ictal or postictal stage of epileptic seizure. However, it remains unclear whether such a change results from persis... | 18,800,632 |
[Elderly patient with cerebellar malignant astrocytoma]. | Malignant cerebellar astrocytoma is very rare and the prognosis is extremely poor. We report herein the case of an elderly patient with malignant cerebellar astrocytoma. This 80-year-old man initially presented with dizziness and ataxia of the right hand. Metastatic cerebellar tumor was diagnosed on first admission, ba... | 18,800,635 |
The security case for patient and family centered care. | Patient and Family Centered Care may be the model that will soon be standard throughout the healthcare industry, the author reports. It is critical, he says, that security directors not only embrace this care model, but that they take an active role in seeing that security is interwoven in the visitation and family pre... | 18,800,653 |
Planning for the worst: one hospital's process for developing an 'active shooter on campus' policy. | Concerned about the potential for a Virginia Tech type tragedy at a hospital, the author contacted colleagues at other hospitals to inquire about their plans to reduce casualties in the event of an active shooter on campus, only to learn that there weren't any. Working with law enforcement, emergency management, risk m... | 18,800,661 |
[Obsessive-compulsive disorder in children and adolescents]. | With a prevalence of about 2% obsessive-compulsive disorder is ranking among the most frequent psychiatric disorders in childhood and adolescence. The symptoms often lead to severe impairments in academic and social life, as well as to family conflicts. Despite the high efficacy of cognitive-behavioural and psychopharm... | 18,800,672 |
[Apoptosis of active T lymphocytes induced by human laryngocarcinoma cell line]. | To observe the expression of Fas receptor and ligand in human laryngocarcinoma cell line, Hep-2 and to investigate the possible mechanism of immune escape through Fas/FasL pathway in Hep-2 cell. The mRNA and protein expressions of Fas and FasL in Hep-2 cell were analyzed by RT-PCR and flow cytometry (FCM). Growth curve... | 18,800,686 |
[Infrared spectroscopy of epimedium brevicornum based on artificial neural network]. | Regarding raw drugs of the different habitat and the different cultivation condition, its treatment efficacy is different. This is because they contain different chemical composition and different ingredients content proportion, which causes the difference in their infrared spectra. But these differences are extremely ... | 18,800,698 |
[Study of interaction between sorbitol and bovine serum albumin by fluorescence spectrometry]. | The interaction of sorbitol and bovine serum album (BSA) was studied by fluorescence and ultraviolet absorption spectra. As it is well known to us, the interactional analysis between small molecular drug and biology macromolecule (such as protein, DNA, etc) is one of the important interactional analyses, which can not ... | 18,800,712 |
[Fluorescence emission analysis of caspase-3 activation induced by Xiao-Ai-Ping (XAP) inside living human lung adenocarcinoma cells]. | The CCK-8 was used to measure the inhibition effect of Xiao-Ai-Ping (XAP), a traditional medicine, on the human lung adenocarcinoma (ASTC-a-1) cells viability. The ASTC-a-1 cells expressing stably with SCAT3, a fluorescence resonance energy transfer (FRET) plasmid based on the green fluorescent protein mutants (GFPs), ... | 18,800,715 |
[Study on the interaction between vincristine and bovine serum albumin]. | The interaction between vincristine (VCR) and bovine serum albumin (BSA) was investigated by UV-Vis absorption, fluorescence and circular dichroism (CD) spectra at 296, 303 and 310 K, respectively. With fluorescence quenching method, the binding constants Ka were determined to be 1.5 x 10(4) L x mol(-1), 9.5 x 10(3) L ... | 18,800,727 |
[Analysis of speciation distribution of se in mungbean during enzymatic hydrolization]. | In the present paper, selenium content in mungbean and selenium speciation distribution in mungbean during enzymatic hydrolization was investigated with AFS-230E atomic fluorescence photometer. Selenium in the decoction and enzymatic hydrolysates samples were separated into two species including primary speciation and ... | 18,800,728 |
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. | Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors to promote survival. Therefore, inhibitors of AKT kinase activity might be useful as monotherapy for the treatment of tumors with activated AKT. Herein, we desc... | 18,800,763 |
Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates. | N-{4-[(2-Amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3- d]pyrimidin-5-yl)sulfanyl]benzoyl}-L-glutamic acid (4) and nine nonclassical analogues 5-13 were synthesized as potential dual thymidylate synthase (TS) and dihydrofolate reductase (DHFR) inhibitors. The key intermediate in the synthesis was 2-amino-6-methylthieno[2,... | 18,800,768 |
Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. | A synthesis of the novel tyrosine analogue (2 S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2 S)-Mdcp] (15) was developed. In (2 S)-Mdcp, the amino and hydroxyl groups of 2',6'-dimethyltyrosine are replaced by a methyl and a carbamoyl group, respectively, and its substitution for Tyr (1) in opioid agon... | 18,800,771 |
Conjugation in polyyne rods: to what extent is charge delocalization coupled to geometrical changes? | Ab initio methods were used to calculate the geometry and the charge distribution (natural bond orbital) in end-protonated polyynes. The geometry obtained is practically identical to that of the corresponding anion and the neutral radical. Thus, the geometry is not much dependent on charge dispersal. Moreover, it is sh... | 18,800,780 |
Polarization-resolved ultrafast polarizability relaxation in polar aromatic liquids. | The isotropic part of the polarizability relaxation of three polar aromatic liquids has been measured as a function of temperature using a diffractive optic based heterodyne detection method. The isotropic spectral density, which contains only interaction induced components of the liquid's collective polarizability, is... | 18,800,786 |
Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model. | This study was conducted to determine whether the daily consumption for 84 days of tyrosol and hydroxytyrosol, the main olive oil phenolic compounds, and olive oil mill wastewater (OMWW), a byproduct of olive oil production, rich in micronutrients, may improve bone loss in ovariectomized rats (an experimental model of ... | 18,800,805 |
Concurrent sensing of benzene and oxygen by a crystalline salt of tris(5,6-dimethyl-1,10-phenanthroline)ruthenium(II). | The complex [Ru(5,6-Me2Phen)3]tfpb2 has been examined as a solid-state benzene and oxygen sensor. The crystalline solid undergoes a reversible vapochromic shift of the emission lambda max to higher energy in the presence of benzene. Additionally, in the presence of oxygen the solid exhibits linear Stern-Volmer quenchin... | 18,800,825 |
Neglected bidentate sp2 N-donor carrier ligands with triazine nitrogen lone pairs: platinum complexes retromodeling cisplatin guanine nucleobase adducts. | Rapid rotation of guanine base derivatives about Pt-N7 bonds results in fluxional behavior of models of the key DNA intrastrand G-G cross-link leading to anticancer activity of Pt(II) drugs (G = deoxyguanosine). This behavior impedes the characterization of LPtG2 models (L = one bidentate or two cis-unidentate carrier ... | 18,800,828 |
Primary and secondary phosphine complexes of iron porphyrins and ruthenium phthalocyanine: synthesis, structure, and P-H bond functionalization. | Reduction of [Fe(III)(Por)Cl] (Por = porphyrinato dianion) with Na2S2O4 followed by reaction with excess PH2Ph, PH2Ad, or PHPh2 afforded [Fe(II)(F20-TPP)(PH2Ph)2] (1a), [Fe(II)(F20-TPP)(PH2Ad)2] (1b), [Fe(II)(F20-TPP)(PHPh2)2] (2a), and [Fe(II)(2,6-Cl2TPP)(PHPh2)2] (2b). Reaction of [Ru(II)(Pc)(DMSO)2] (Pc = phthalocya... | 18,800,835 |
Silver-promoted domino Pd-catalyzed amination/direct arylation: access to polycyclic heteroaromatics. | Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald-Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts. | 18,800,841 |
Expeditious total syntheses of natural allenic products via aromatic ring umpolung. | Concise diastereoselective syntheses of the marine (+/-)-panacene and terrestrial (+/-)-desbromopanacene have been achieved in a few steps based on a concept of "aromatic ring umpolung". The synthetic avenue to the (+/-)-panacene involved a novel oxymercuration strategy to produce the correct configuration of the bromo... | 18,800,844 |
Benzodichalcogenophenes with perfluoroarene termini. | Benzodichalcogenophenes are functionalized at their termini via SN Ar reactions of their bismetalates with perfluoroarenes. The identities of X, Y, and W are varied to study the effects on LUMO energy levels and crystallization motif. X-ray crystallography reveals that nearly all new derivatives crystallize with coplan... | 18,800,845 |
Influence of hosts on the ecology of arboviral transmission: potential mechanisms influencing dengue, Murray Valley encephalitis, and Ross River virus in Australia. | Ecological interactions are fundamental to the transmission of infectious disease. Arboviruses are particularly elegant examples, where rich arrays of mechanisms influence transmission between vectors and hosts. Research on host contributions to the ecology of arboviral diseases has been undertaken within multiple subd... | 18,800,866 |
Long-term IOP lowering with bimatoprost in open-angle glaucoma patients poorly responsive to latanoprost. | The aim of this study was to study long-term intraocular pressure (IOP) lowering following a switch to bimatoprost in patients with open-angle glaucoma (OAG) not at target IOP while on latanoprost either as monotherapy or as polytherapy with other topical adjunctive agents. A retrospective review of OAG patients, with ... | 18,800,869 |
New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse. | The purpose of this study was to investigate the improvement of allergic dermatitis in chemical allergen-induced mice by Lactobacillus sakei probio 65. L. sakei probio-65 was isolated from kimchi, a traditional Korean fermented food. This strain was resistant to gastric acidity, bile, and several antibiotics and posses... | 18,800,885 |
Hypoglycemic effect of Lentinus strigosus (Schwein.) Fr. crude exopolysaccharide in streptozotocin-induced diabetic rats. | ABSTRACT This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, diabetic rats were treated with EPS at doses of 50-150 m... | 18,800,900 |
Anti-inflammatory activity of the ethanol extract of Chungkukjang, Korean fermented bean: 5-lipoxygenase inhibition. | The anti-inflammatory activity of Chungkukjang, a Korean traditional fermented soybean food (Korean-style Natto), was examined for the first time. From the results, it was found that the ethanol extract of Chungkukjang inhibited 5-lipoxygenase from A23187-treated RBL-1 cells, reducing leukoriene production (50% inhibit... | 18,800,904 |
Investigation on the mineral contents of capers (Capparis spp.) seed oils growing wild in Turkey. | Minor and major mineral contents of seed oils of Capparis ovata Desf. var. canescens (Coss.) Heywood and Capparis spinosa var. spinosa used as pickling products in Turkey were determined by inductively coupled plasma atomic emission spectrometry. The seed oils contained Al, P, Na, Mg, Fe, and Ca, in addition to fatty a... | 18,800,913 |
Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal. | Myocardial ischaemia is associated with the generation of lipid peroxidation products such as HNE (4-hydroxy-trans-2-nonenal); however, the processes that predispose the ischaemic heart to toxicity by HNE and related species are not well understood. In the present study, we examined HNE metabolism in isolated aerobic a... | 18,800,966 |
Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. | The role of naturally occurring regulatory T cells (Treg), known to be phenotypically heterogeneous, in controlling the expression of systemic lupus erythematosus (SLE) is incompletely defined. Therefore, different subpopulations of CD4(+) FoxP3(+) Tregs in patients with active or inactive SLE were investigated and com... | 18,800,986 |
The constitution of 'lavender families': a LGB perspective. | To explore and describe lesbian, gay and bisexual people's families of origin and families of choice. As a family group lesbian, gay and bisexual people engage with nurses when they interface with any health care service. All health practitioners need to be aware of the existence and constitution of lesbian, gay and bi... | 18,800,992 |
At Baltic crossroads: a molecular snapshot of Mycobacterium tuberculosis population diversity in Kaliningrad, Russia. | The Kaliningrad region is the westernmost part of the Russian Federation; it includes an enclave on the Baltic Sea inside the European Union separated from mainland Russia by Lithuania and Poland. The incidence of tuberculosis in Kaliningrad has shown a steady and dramatic increase from 83/100,000 in 2000 to 134/100,00... | 18,801,045 |
Characterization of Caulobacter crescentus response to low temperature and identification of genes involved in freezing resistance. | Free-living bacteria must respond to a wide range of temperature changes, and have developed specific mechanisms to survive in extreme environments. In this work we describe a remarkable resistance of mesophilic bacterium Caulobacter crescentus to several cycles of freezing at -80 degrees C, which was able to grow at l... | 18,801,049 |
Clinical trial: a randomized trial of early endoscopy, Helicobacter pylori testing and empirical therapy for the management of dyspepsia in primary care. | Early endoscopy, Helicobacter pylori eradication and empirical acid suppression are commonly used dyspepsia management strategies in primary care but have not been directly compared in a single trial. To compare endoscopy, H. pylori test and refer, H. pylori test and treat and empirical acid suppression for dyspepsia i... | 18,801,056 |
Poor correlations between measurements of bone quality by quantitative ultrasound sonography and dual energy X-ray absorptiometry in patients with beta-thalassaemia major. | Osteopenia/osteoporosis is a major component of morbidity even in young patients with beta-thalassaemia major. Dual energy X-ray absorptiometry (DXA) is the reference method for determining bone mineral density (BMD). Quantitative ultrasound sonography (QUS) for bone measurement is a relatively new, inexpensive and rad... | 18,801,057 |
Mechanisms of EHD/RME-1 protein function in endocytic transport. | The evolutionarily conserved Eps15 homology domain (EHD)/receptor-mediated endocytosis (RME)-1 family of C-terminal EH domain proteins has recently come under intense scrutiny because of its importance in intracellular membrane transport, especially with regard to the recycling of receptors from endosomes to the plasma... | 18,801,062 |
Alterations of DNA methylation and clinicopathological diversity of human cancers. | Alterations of DNA methylation can account for the histological heterogeneity, reflected in the stepwise progression and complex biological characteristics of human cancers, that genetic alterations alone cannot explain. Analysis of DNA methylation status in tissue samples can be an aid to understanding the molecular m... | 18,801,069 |
EBV-associated diffuse large B-cell lymphoma arising in the chest wall with surgical mesh implant. | In Japan, most cases of malignant lymphoma arising in the thorax are pyothorax-associated lymphoma, which develops in patients who have undergone artificial pneumothorax, used in the past as surgical therapy for pulmonary tuberculosis. Pyothorax-associated lymphoma consist mostly of diffuse large B-cell lymphoma and ha... | 18,801,089 |
A unique case of multiple dermatomyofibromas. | We report on a case of multiple dermatomyofibromas on the posterior neck of a 10-year-old boy. Dermatomyofibroma is a benign proliferation of myofibroblasts of the skin. It is more common in adolescents and young adults, with a female preponderance. It usually appears as a single plaque or nodule. To our knowledge, thi... | 18,801,097 |
A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride. | Eticlopride is a substituted benzamide analog with high affinity and selectivity for dopamine (DA) D2-like receptors that was initially developed as a potential antipsychotic agent. A great deal of research has utilized this drug to better understand central DA receptor function, the role of D2-like receptors in behavi... | 18,801,115 |
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