title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Children's performance in mental rotation tasks: orientation-free features flatten the slope. | Studies of the development of mental rotation have yielded conflicting results, apparently because different mental rotation tasks draw on different cognitive abilities. Children may compare two stimuli at different orientations without mental rotation if the stimuli contain orientation-free features. Two groups of chi... | 18,801,129 |
Quality of psoriasis care in Germany--results of the national study PsoHealth 2007. | Many different forms of treatment are available for psoriasis. The German standard is the national AWMF S3 guideline. A national survey on psoriasis care in 2005 indicated deficits in psoriasis care in Germany. Assessment of the health care situation of patients with psoriasis in Germany. Nation-wide cross-sectional st... | 18,801,145 |
On the origin of trisomy 21 Down syndrome. | Down syndrome, characterized by an extra chromosome 21 is the most common genetic cause for congenital malformations and learning disability. It is well known that the extra chromosome 21 most often originates from the mother, the incidence increases with maternal age, there may be aberrant maternal chromosome 21 recom... | 18,801,168 |
Frequency, factors and costs associated with injection site infections: findings from a national multi-site survey of injecting drug users in England. | Injection site infections among injecting drug users (IDUs) have been associated with serious morbidity and health service costs in North America. This study explores the frequency, factors and costs associated with injection site infections among IDUs in England. Unlinked-anonymous survey during 2003/05 recruiting IDU... | 18,801,177 |
Lung adenocarcinoma with micropapillary component presenting with metastatic scrotum tumor and cancer-to-cancer metastasis: A case report. | A 54-year-old man was admitted to the hospital presenting with a 3-month history of sclerosing dermal lesion in the external genitalia. A scrotal skin biopsy revealed a poorly-differentiated adenocarcinoma, immunohistochemically positive for cytokeratin 7 (CK7) and for thyroid transcription factor 1 (TTF-1), and negat... | 18,801,198 |
Humeral biepicondylar fracture dislocation in a child: A case report and review of the literature. | Humeral biepicondylar fracture dislocation is a very rare injury reported only once in English literature by G R Taylor et al. We report a case of humeral biepicondylar fracture dislocation in a 13-year-old girl with a unique mechanism of injury. A 13-year-old girl presented with trauma elbow. Radiographs showed biepic... | 18,801,199 |
Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. | The APOA1-C3-A5 gene cluster plays an important role in the regulation of lipids. Asian Indians have an increased tendency for abnormal lipid levels and high risk of Coronary Artery Disease (CAD). Therefore, the present study aimed to elucidate the relationship of four single nucleotide polymorphisms (SNPs) in the Apo1... | 18,801,202 |
Cognitive performance and quality of life in bipolar disorder. | In patients with bipolar disorder (BD), quality of life (QOL) scores have been largely attributed to mood symptoms. However, impairments in QOL may occur even in euthymia, and differential factors have been put forward as important determinants of QOL. Our study was designed to assess the role of cognitive performance ... | 18,801,213 |
Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and metaanalysis. | Systematic reviews show that repetitive transcranial magnetic stimulation (rTMS) is superior to sham control conditions in patients with major depressive disorder, but the clinical relevance is not clear. None have specifically examined outcomes in patients with treatment-resistant depression (TRD). A systematic review... | 18,801,225 |
Accurate concentration measurements using surface-enhanced Raman and deuterium exchanged dye pairs. | Quantitative applications of surface-enhanced resonance Raman scattering (SERRS) are often limited by the reproducibility of SERRS intensities, given the difficulty of controlling analyte-substrate interactions and the associated local field enhancement. As demonstrated here, SERRS from dye molecules even within the sa... | 18,801,239 |
Potential of far-ultraviolet absorption spectroscopy as a highly sensitive analysis method for aqueous solutions. Part II: monitoring the quality of semiconductor wafer cleaning solutions using attenuated total reflection. | Far-ultraviolet (FUV) spectroscopy combined with attenuated total reflection (ATR) is employed for direct measurement of the concentrations of semiconductor wafer cleaning fluids such as SC-1 (aqueous solution of NH3 and H2O2) and SC-2 (aqueous solution of HCl and H2O2). FUV spectra of these aqueous solutions in the 17... | 18,801,242 |
Multipartite symbioses among fungi, mites, nematodes, and the spruce beetle, Dendroctonus rufipennis. | The spruce beetle, Dendroctonus rufipennis, is an eruptive forest pest of significant economic and ecological importance. D. rufipennis has symbiotic associations with a number of microorganisms, especially the ophiostomatoid fungus Leptographium abietinum. The nature of this interaction is only partially understood. A... | 18,801,261 |
Vitamin D deficiency treated by consuming UVB-irradiated mushrooms. | Deficiency of vitamin D is usually caused by dietary deficiency and/or lack of exposure to sunlight in dark skinned individuals living at northern latitudes. Simple vitamin D deficiency is commonly treated by prescribing a vitamin D containing calcium supplement. This report presents a patient who rejected this approac... | 18,801,283 |
Correlation of lipid peroxidation and glutathione levels with severity of systemic lupus erythematosus: a pilot study from single center. | Systemic Lupus Erythematosus (SLE) is a multifactoral chronic autoimmune disease with unidentified etiology. Imbalance of oxidative status is one possible cause of active disease. Plasma malondialdehyde (MDA) and plasma glutathione (GSH) level have been used as a determinate of oxidative status. Limited data has examin... | 18,801,305 |
Emergence of power laws in the pharmacokinetics of paclitaxel due to competing saturable processes. | This study presents the results of power law analysis applied to the pharmacokinetics of paclitaxel. Emphasis is placed on the role that the power exponent can play in the investigation and quantification of nonlinear pharmacokinetics and the elucidation of the underlying physiological processes. Forty-one sets of conc... | 18,801,309 |
In vivo activity of perifosine against Leishmania amazonensis. | Miltefosine has been established as the first oral administration drug against cutaneous and visceral leishmaniasis. Other alkyl-phospholipids such as edelfosine have been tested against Leishmania showing an in vitro antiparasitic activity. Perifosine in vitro activity has been previously demonstrated against differen... | 18,801,328 |
Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1. | Glucose toxicity is an important initiator of cardiovascular disease, contributing to the development of cardiomyocyte death and diabetic complications. The present study investigated whether high glucose state could induce apoptosis of rat cardiomyocyte cell line H9C2 through microRNA regulated insulin-like growth fac... | 18,801,338 |
Ferroplasma acidarmanus RPA2 facilitates efficient unwinding of forked DNA substrates by monomers of FacXPD helicase. | The strand-separation activity that is important for many cellular DNA processing machineries is provided by DNA helicases. In order to understand the physiological properties of a helicase acting in the context of its macromolecular machinery, it is imperative to identify the proteins that interact with the enzyme and... | 18,801,373 |
A critical band of phase alignment for discrimination but not recognition of human faces. | We investigated the processes underlying the discrimination and recognition of human faces as a function of spatial phase alignment to assess whether face processing can be understood in terms of the amplitude spectrum alone. Specifically, we varied the amount of aligned Fourier phase in different regions of the face f... | 18,801,383 |
Hyperthermia amplifies brain cytokine and reactive oxygen species response in a model of perinatal inflammation. | Chorioamnionitis, a perinatal infection of the fetal membranes, and maternal fever, which often accompanies infection are both risk factors for cerebral palsy (CP). Inflammation is a typical reaction to infection. Thus the aim of this study was to determine if hyperthermia alters newborn rat brain inflammatory response... | 18,801,411 |
Neuromuscular synaptic function in mice lacking major subsets of gangliosides. | Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission. We have measured in detail the electrophysiological parameters of synaptic transmission at... | 18,801,416 |
Similar compounds searching system by using the gene expression microarray database. | Numbers of microarrays have been examined and several public and commercial databases have been developed. However, it is not easy to compare in-house microarray data with those in a database because of insufficient reproducibility due to differences in the experimental conditions. As one of the approach to use these d... | 18,801,419 |
Molecular diversity and association mapping of fiber quality traits in exotic G. hirsutum L. germplasm. | The narrow genetic base of cultivated cotton germplasm is hindering the cotton productivity worldwide. Although potential genetic diversity exists in Gossypium genus, it is largely 'underutilized' due to photoperiodism and the lack of innovative tools to overcome such challenges. The application of linkage disequilibri... | 18,801,424 |
Effect of dietary ascorbic acid on growth and non-specific immune responses of tiger puffer, Takifugu rubripes. | We report nutritional physiology and non-specific immune responses of ascorbic acid (AA) in puffer fish for the first time. This study aimed to examine the essentiality and requirements of AA in diets for the tiger puffer, Takifugu rubripes based on growth performance, liver AA and bone collagen concentration, and non-... | 18,801,440 |
Dissociable neural mechanisms for determining the perceived heaviness of objects and the predicted weight of objects during lifting: an fMRI investigation of the size-weight illusion. | In size-weight (SW) illusions, people learn to scale their fingertip forces for lifting small and big objects of equal weight even though they fail to learn perceptually that both objects have the same weight. The question then arises as to what the separate neural mechanisms are for determining the perceived heaviness... | 18,801,445 |
Phylogeny and biogeography of the family Salamandridae (Amphibia: Caudata) inferred from complete mitochondrial genomes. | Phylogenetic relationships of members of the salamander family Salamandridae were examined using complete mitochondrial genomes collected from 42 species representing all 20 salamandrid genera and five outgroup taxa. Weighted maximum parsimony, partitioned maximum likelihood, and partitioned Bayesian approaches all pro... | 18,801,447 |
Binding to protein surfaces by supramolecular multivalent scaffolds. | Multivalency plays a pivotal role in biological recognition, particularly at protein-protein and protein-carbohydrate interaction sites. Scaffolds of diverse structure, flexibility, and valency are gaining increasing biomedical importance in the development of artificial multivalent ligands for these interfaces. Releva... | 18,801,458 |
Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism. | Major depressive disorder (MDD) occurs in a subset of patients receiving interferon-alpha treatment, although many are resilient to this side effect. Genetic differences in the serotonin reuptake transporter promoter (5-HTTLPR) may interact with the inflammatory system and influence depression risk. A cohort of 71 nond... | 18,801,474 |
Application and limitations of the methyl imidate protection strategy of N-acetylglucosamine for glycosylations at O-4: synthesis of Lewis A and Lewis X trisaccharide analogues. | We describe here the synthesis of the allyl Le(a) trisaccharide antigen as well as that of an analogue of the Le(x) trisaccharide antigen, in which the galactose residue has been replaced by a glucose unit. Although successful fucosylations at O-4 of N-acetylglucosamine acceptors have been reported using perbenzylated ... | 18,801,477 |
Practical solvent system selection for counter-current separation of pharmaceutical compounds. | Counter-current chromatography (CCC) is a technique that shows a lot of potential for large scale purification. Its usefulness in a "research and development" pharmaceutical environment has been investigated, and the conclusions are shown in this article. The use of CCC requires the development of an appropriate solven... | 18,801,491 |
How to use an article about therapy. | Most surgical interventions have inherent benefits and associated risks. Before implementing a new therapy we should ascertain the benefits and risks of the therapy and assure ourselves that the resources consumed in the intervention will not be exorbitant. We suggest a 3-step approach to using an article from the urol... | 18,801,503 |
Western Equine Encephalitis submergence: lack of evidence for a decline in virus virulence. | The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1-2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanation for the decline in the nu... | 18,801,549 |
Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques. | Angiotensin converting enzyme 2 (ACE2) is the receptor that severe acute respiratory syndrome coronavirus (SARS-CoV) utilizes for target cell entry and, therefore, plays an important role in SARS pathogenesis. Since Chinese rhesus (rh) macaques do not usually develop SARS after SARS-CoV infection, it has been suggested... | 18,801,550 |
Temperature-dependent production of pseudoinfectious dengue reporter virus particles by complementation. | Dengue virus (DENV) is a mosquito-borne flavivirus responsible for 50 to 100 million human infections each year, highlighting the need for a safe and effective vaccine. In this study, we describe the production of pseudoinfectious DENV reporter virus particles (RVPs) using two different genetic complementation approach... | 18,801,552 |
The accuracy and clinical application of predictive models for primary open-angle glaucoma in ocular hypertensive individuals. | This report compares the accuracy of 3 prediction models for the development of primary open-angle glaucoma (POAG). The models differ primarily in their handling of these eye-specific variables: intraocular pressure (IOP), central corneal thickness (CCT), vertical cup-to-disc ratio (VCD), and visual field pattern stand... | 18,801,578 |
Alteration of frontal EEG asymmetry during tryptophan depletion predicts future depression. | Tryptophan depletion (TD) reduces brain serotonin and may induce acute depressive symptomatology, especially among those with a history of Major Depression. Depressive response to TD among euthymic patients with a history of depression also predicts future depression. Better prediction might result by assessing a putat... | 18,801,582 |
Kinetic study of the degradation of the insecticide pymetrozine in a vegetable-field ecosystem. | The disappearance kinetics of pymetrozine was studied in a broccoli-field ecosystem, and an efficient method for the determination of pymetrozine in broccoli and soil was also developed. Pymetrozine residues were extracted from samples using acetonitrile. The extracts were cleaned up by liquid-liquid partitioning with ... | 18,801,616 |
Cross-cultural invalidity of alcohol dependence measurement across Hispanics and Caucasians in 2001 and 2002. | Do assessments of alcohol dependence demonstrate similarly validity across Hispanics and non-Hispanic Caucasians? This investigation examined this question. It employed confirmatory factor analyses for ordered-categorical measures to search for measurement bias on the AUDADIS, a standardized measure of alcohol dependen... | 18,801,620 |
Examiner repeatability of patellar cartilage T2 values. | The purpose of this study was to evaluate the intra- and interexaminer resegmentation precision of patellar cartilage T2 mapping measurements in healthy subjects. T2-weighted images of patellar cartilage for 10 subjects were acquired. Two individuals manually segmented patellar cartilage at each slice location twice, o... | 18,801,631 |
Characterization of cardiac-related noise in fMRI of the cervical spinal cord. | Magnetic resonance imaging (MRI) has recently been applied to study spinal cord function in humans. However, spinal functional MRI (fMRI) encounters major technical challenges with cardiac noise being considered a major source of noise. The present study relied on echo-planar imaging of the cervical cord at short TR (T... | 18,801,632 |
Metrologic approaches to setting acceptance criteria: unacceptable and unusual characteristics. | Decisions regarding acceptance criteria in regulatory or compendial contexts are among the most difficult to make. Acceptance criteria aid in the identification, on the one hand, of materials with unacceptable characteristics that should not pass the tests and procedures or, on the other hand, of unusual characteristic... | 18,801,635 |
Right-sided vagus nerve stimulation in humans: an effective therapy? | Vagus nerve stimulation (VNS) is an additive treatment option for refractory epilepsy. The electrode is placed on the cervical trunk of the left vagus nerve. In patients who are not suitable for left-sided vagus nerve stimulation (L-VNS) right-sided vagus nerve stimulation (R-VNS) may be as effective. In animal models ... | 18,801,642 |
"Resting" CBF in the epileptic baboon: correlation with ketamine dose and interictal epileptic discharges. | Photosensitive epileptic (SZ) baboons demonstrate different cerebral blood flow (CBF) activation patterns from asymptomatic controls (CTL) during intermittent light stimulation (ILS). This study compares "resting" CBF between PS and CTL animals, and CBF correlations with ketamine dose and interictal epileptic discharge... | 18,801,644 |
Endoscopically assisted enucleation and curettage of large mandibular odontogenic keratocyst. | This article reports a case of a mandibular multilocular keratocyst treated with endoscopically assisted enucleation and curettage. An ectopic third molar displaced in the coronoid process area was also removed.Odontogenic keratocysts (OKCs) are known for their propensity to recur. The incomplete removal of the cyst is... | 18,801,672 |
Fungal infection as a complication of sinus bone grafting and implants: a case report. | Sinus bone grafts have been used successfully to augment atrophic posterior maxilla for dental implant placement. Even though sinus bone grafting is generally considered to be a safe surgical procedure, postoperative maxillary sinus infections can occur and therefore need to be considered. Bacteria, as well as viruses ... | 18,801,673 |
Spectral studies of Fe(III) complexes of dipodal tridentate chelating agents. | The dipodal ligands (Im) and (BIm) as well as complexes [FeLCl(3)] [L=Im (1) and BIm (2)] have been prepared and studied using spectroscopic techniques. The magnetic moment, IR, electronic (ligand field), FAB-mass and NMR spectral data indicate a hexa-coordinate geometry around high-spin state Fe(3+) where the ligands ... | 18,801,699 |
Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. | Whole genome oligo-microarrays were used to characterize age-dependent and tissue-specific changes in gene expression in pancreatic lymph nodes, spleen, and peripheral blood cells, obtained from up to 8 individual NOD mice at 6 different time points (1.5 to 20 weeks of age), compared to NOD.B10 tissue controls. "Milest... | 18,801,706 |
AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. | AMP-activated protein kinase (AMPK) activation reportedly suppresses transcriptional activity of the cAMP-responsive element (CRE) in the phosphoenolpyruvate carboxykinase C (PEPCK-C) promoter and reduces hepatic PEPCK-C expression. Although a previous study found TORC2 phosphorylation to be involved in the suppression... | 18,801,732 |
An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. | Human brains retain discrete populations of micro RNA (miRNA) species that support homeostatic brain gene expression functions; however, specific miRNA abundance is significantly altered in neurological disorders such as Alzheimer disease (AD) when compared with age-matched controls. Here we provide evidence in AD brai... | 18,801,740 |
Functional modules integrating essential cellular functions are predictive of the response of leukaemia cells to DNA damage. | Childhood B-precursor lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Despite the fact that 80% of ALL patients respond to anti-cancer drugs, the patho-physiology of this disease is still not fully understood. mRNA expression-profiling studies that have been performed have not yet provided novel... | 18,801,750 |
Running in new and worn shoes: a comparison of three types of cushioning footwear. | In this study, the effect of shoe degradation on running biomechanics by comparing the kinetics and kinematics of running in new and worn shoes was investigated. Three types of footwear using different cushioning technologies were compared. Longitudinal study. Pre- and post-tests on overground running at 4.5 m s(-1) on... | 18,801,775 |
The impact of allogenic red cell transfusion and coated bypass circuit on the inflammatory response during cardiopulmonary bypass: a randomized study. | This study is designed to determine and compare the effects of transfusion and coated circuits on the inflammatory response during cardiopulmonary bypass. Forty patients were randomized into two groups according to the type of extracorporeal circuit used and later prospectively enrolled into two subgroups according to ... | 18,801,802 |
Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire. | Few studies have examined the subjective value attributed to drug rewards specifically as it compares with the value attributed to primary non-drug rewards in addicted individuals. The objective of this study is to assess 'liking' and 'wanting' of expected 'drug' rewards as compared to 'food' and 'sex' while respondent... | 18,801,822 |
Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale. | Sexual dysfunction (SD) is a common and underestimated effect of antidepressants. Healthy volunteers are the most adequate group to study this adverse event avoiding influence of depression itself. Sexual acceptability of agomelatine (a melatonergic agonist and 5HT(2C) antagonist) paroxetine and placebo by using the Ps... | 18,801,825 |
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature. | Although the relationship between antipsychotic medication, particularly second-generation antipsychotics (SGAs), and metabolic disturbance is increasingly accepted, there is an important, but little recognised, potential interaction between this and the other important serious adverse effect of neuroleptic malignant s... | 18,801,826 |
Effect of weight-bearing activity on foot ulcer incidence in people with diabetic peripheral neuropathy: feet first randomized controlled trial. | Weight-bearing exercise has been contraindicated among people with diabetic peripheral neuropathy (DM+PN). However, recent cohort studies have suggested that daily weight-bearing activity is associated with lower risk for foot ulceration. The objective of this study was to determine the effect of a lower-extremity exer... | 18,801,859 |
The association between water supply and inflammatory bowel disease based on a 1990-1993 cohort study in southeastern Norway. | Inflammatory bowel disease refers to a group of chronic diseases of unknown etiology related to both genetic and environmental factors. In this 1990-1993 study, the authors investigated associations between the content and quality of drinking water and the incidence of inflammatory bowel disease. They used data from a ... | 18,801,890 |
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. | The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1RKO) and compared them with cardiomyocyte-specific insulin receptor kno... | 18,801,929 |
Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. | Quantification of serum tumor markers plays an important role in determining whether patients treated for cancer require further therapy. Whereas large-scale proteomic efforts aim to identify novel tumor markers to facilitate early detection, optimization of methods for quantifying known tumor markers offers another ap... | 18,801,935 |
Habitual physical activity and sports participation after total ankle arthroplasty. | There is a lack of detailed information about habitual physical activity levels and the sports participation of patients after total ankle arthroplasty. The proportion of sports active patients increases after total ankle arthroplasty, and the majority of patients will meet current recommendations for health-enhancing ... | 18,801,943 |
NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. | Cholestasis causes hepatocyte death, possibly because of mitochondrial injury. This study investigated whether NIM811 (N-methyl-4-isoleucine cyclosporine), an inhibitor of the mitochondrial permeability transition (MPT), attenuates cholestatic liver injury in vivo. Cholestasis was induced in mice by bile duct ligation ... | 18,801,946 |
Evidence of skeletal muscle damage following electrically stimulated isometric muscle contractions in humans. | It is unknown whether muscle damage at the level of the sarcomere can be induced without lengthening contractions. To investigate this, we designed a study where seven young, healthy men underwent 30 min of repeated electrical stimulated contraction of m. gastrocnemius medialis, with the ankle and leg locked in a fixed... | 18,801,957 |
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. | We have previously reported that 5 days of a high-fat diet followed by 1 day of high-carbohydrate intake (Fat-adapt) increased rates of fat oxidation and decreased rates of muscle glycogenolysis during submaximal cycling compared with consumption of an isoenergetic high-carbohydrate diet (HCHO) for 6 days (Burke et al.... | 18,801,964 |
Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes. | It is imperative to develop more efficient processes for conversion of biomass to liquid fuels, such that the cost of these fuels would be competitive with the cost of fuels derived from petroleum. We report a catalytic approach for the conversion of carbohydrates to specific classes of hydrocarbons for use as liquid t... | 18,801,970 |
Comment on "Age and evolution of the Grand Canyon revealed by U-Pb dating of water table-type speleothems". | Polyak et al. (Reports, 7 March 2008, p. 1377) reported that development of the western Grand Canyon began about 17 million years ago. However, their conclusion is based on an inappropriate conflation of Plio-Quaternary incision rates and longer-term rates derived from sites outside the Grand Canyon. Water-table declin... | 18,801,984 |
Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity. | The nucleostemin (NS) gene encodes a nucleolar protein found at high levels in several types of stem cells and tumor cell lines. The function of NS is unclear but it may play a critical role in S-phase entry by stem/progenitor cells. Here we characterize NS expression in murine male germ cells. Although NS protein was ... | 18,802,033 |
Induction of a VLA-2 (CD49b)-expressing effector T cell population by a cell-based neuroblastoma vaccine expressing CD137L. | In malignancies where no universally expressed dominant Ag exists, the use of tumor cell-based vaccines has been proposed. We have modified a mouse neuroblastoma cell line to express either CD80 (B7.1), CD137L (4-1BBL), or both receptors on the tumor cell surface. Vaccines expressing both induce a strong T cell respons... | 18,802,064 |
Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase. | Infiltration of activated monocytes into the brain is a prerequisite for the development of various neurological disorders such as HIV-associated dementia, multiple sclerosis, and other inflammatory processes. In these pathologies, the chemokine SDF-1alpha (CXCL12) is over-expressed and might attract monocytes into the... | 18,802,065 |
Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation. | The secreted goblet cell-derived protein resistin-like molecule beta (RELMbeta) has been implicated in divergent functions, including a direct effector function against parasitic helminths and a pathogenic function in promoting inflammation in models of colitis and ileitis. However, whether RELMbeta influences CD4(+) T... | 18,802,073 |
Vaccination-induced systemic autoimmunity in farmed Atlantic salmon. | Over half of the salmon consumed globally are farm-raised. The introduction of oil-adjuvanted vaccines into salmon aquaculture made large-scale production feasible by preventing infections. The vaccines that are given i.p. contain oil adjuvant such as mineral oil. However, in rodents, a single i.p. injection of adjuvan... | 18,802,084 |
Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. | Destruction of virus-infected cells by CTL is an extremely sensitive and efficient process. Our previous data suggest that LFA-1-ICAM-1 interactions in the peripheral supramolecular activation cluster (pSMAC) of the immunological synapse mediate formation of a tight adhesion junction that might contribute to the sensit... | 18,802,085 |
Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. | The various functions of gelsolin in extracellular compartments are not yet clearly defined but include actin scavenging and antiinflammatory effects. Gelsolin was recently reported to bind endotoxin (LPS) from various Gram-negative bacteria with high affinity. In this study we investigate whether gelsolin also interac... | 18,802,097 |
Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation. | To evaluate the feasibility of a 10-gene reverse transcriptase polymerase chain reaction assay to identify the tissue of origin in patients with carcinoma of unknown primary (CUP) site. Diagnostic biopsy formalin-fixed, paraffin-embedded (FFPE) specimens from 120 patients with CUP were collected retrospectively from Sa... | 18,802,157 |
Randomized controlled trial of collaborative care management of depression among low-income patients with cancer. | To determine the effectiveness of the Alleviating Depression Among Patients With Cancer (ADAPt-C) collaborative care management for major depression or dysthymia. Study patients included 472 low-income, predominantly female Hispanic patients with cancer age >or= 18 years with major depression (49%), dysthymia (5%), ... | 18,802,161 |
Emotional responses of staff to assault in a pediatric state hospital. | In this study, we examined the emotional responses of staff to patient-on-staff assault at a state inpatient psychiatric hospital for children and adolescents. Staff (n = 93) completed self-report measures assessing general psychiatric functioning and symptoms of depression and anxiety. Staff assaulted by patients in t... | 18,802,185 |
Defining mental disorder when it really counts: DSM-IV-TR and SVP/SDP statutes. | Civil commitment under the sexually violent predator (SVP) statutes requires the presence of a statutorily defined diagnosed mental disorder linked to sexual offending. As a consequence of broad statutory definitions and ambiguously written court decisions, a bright line separating an SVP mental disorder from ordinary ... | 18,802,187 |
Delay to diagnosis in acute pediatric arterial ischemic stroke. | For the clinician, the diagnosis of arterial ischemic stroke (AIS) in children is a challenge. Prompt diagnosis of pediatric AIS within 6 hours enables stroke-specific thrombolytic and neuroprotective strategies. We conducted a retrospective study of prospectively enrolled consecutive cohort of children with AIS, admit... | 18,802,206 |
Retrograde catheterization of haemodialysis fistulae and grafts: angiographic depiction of the entire vascular access tree and stenosis treatment. | The European Best Practice Guidelines on Vascular Access propose magnetic resonance angiography (MRA) of dysfunctional dialysis fistulae and grafts if visualization of the complete arterial inflow and outflow vessels is needed. In a prospective multi-centre study we determined the technical success rate of complete vas... | 18,802,208 |
Control of development of gastrointestinal system in neonates. | Our recent studies of structure and function of gastrointestinal tract mucosa revealed that the domestification of Sus scrofa corresponds with the significant slowing of the organ development. On top of genetic potential, the nutritional factors (or more precisely - lack of certain biologically active substances in the... | 18,802,215 |
A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems. | Prostaglandins are primary mediators of pain and are involved in pathological conditions such as hypertension, cancer and inflammation but are also needed for normal function of the female reproductive system. This may hold true for other systems because long term use of selective COX-2 inhibitors such as VIOXX and BEX... | 18,802,217 |
Postural Correction in Persons with Neck Pain (II. Integrated Electromyography of the Upper Trapezius in Three Simulated Neck Positions). | In the previous paper (Enwemeka, Bonet, Ingle, et al. 8:235-239, 1986) we showed that patients with neck pain and spasm of the upper trapezius often assume a forward head position, and that two neck positions, axial extension, and neutral neck position are frequently used by physical therapists to correct this faulty n... | 18,802,224 |
Reliability of a noninvasive method for measuring the lumbar curve*. | The purposes of this paper were to describe a clinically useful and noninvasive method of characterizing the shape of the lumbar spine and to evaluate the reliability and validity of this measurement technique. A flexible ruler was applied to the skin over the lumbar spines of 23 normal adults and an angle in degrees b... | 18,802,227 |
Femoral transverse torque: an assessment method. | This study compared external and internal femoral torques of asymptomatic male and female subjects. Peak torque values were recorded using the Cybex(R) II isokinetic dynamometer utilizing a prone testing position with the hip in neutral. Males produced significantly higher raw peak torques than females in both external... | 18,802,252 |
Fatigue Response in Human Quadriceps Femoris Muscle during High Frequency Electrical Stimulation*. | The purpose of this study was to examine the fatigue response of the quadriceps femoris muscle to two patterns of high frequency alternating electrical current. Muscle fatigue was evaluated by the comparison of isometric torque fluctuations during the 10-minute application of both stimulus patterns. Muscle fatigue was ... | 18,802,271 |
Biomechanics of the shoulder. | The terminology of engineering has made biomechanics unnecessarily confusing and intimidating to many clinicians. Frankel and Burnstein's4 classic text on orthopedic biomechanics was so difficult to understand that it was not fully appreciated. Fortunately, the gap between mechanical engineers and clinicians has been ~... | 18,802,308 |
The effects of passive joint mobilization on pain and hypomobility associated with adhesive capsulitis of the shoulder. | The purpose of this investigation was to determine the effects of passive mobilization and active exercises in patients with painfully restricted shoulders. Twenty patients with painful glenohumeral restrictions were randomly placed in one of two groups. The experimental group received mobilization and active exercises... | 18,802,309 |
Air-borne microbial contamination of surfaces in a UK dental clinic. | Little is known about the number, type, or antibiotic resistance profiles, of air-borne microbes present in hospital settings yet such information is important in designing effective measures to reduce cross-infection. In this study settle plates were used to identify and quantify the air-borne microbes present in a de... | 18,802,318 |
Microbial community in the rhizosphere of young maize seedlings is susceptible to the impact of introduced pseudomonads as indicated by FAME analysis. | Two species of Pseudomonas (i.e. P. chlororaphis or P. putida) derived from a maize rhizosphere were studied for their impact on the structure of the microbial community in the rhizosphere of young maize seedlings after inoculation. The culturable bacteria and total microbial communities were analyzed based on profiles... | 18,802,319 |
Mast cells and mast cell-derived factors in the regulation of allergic sensitization. | Mast cells have been mainly regarded as effector cells in IgE-dependent mucosal immunity, including the host response to helminthic parasites but also the formidable and sometimes fatal anaphylactic reactions to inhaled or ingested allergens. Work performed mostly within the last decade revealed novel functions for mas... | 18,802,337 |
Immune regulation and tolerance to fungi in the lungs and skin. | The balance of pro- and anti-inflammatory signaling is a prerequisite for successful host/fungal interactions and requires the coordinate actions of both innate and adaptive immune systems. Although inflammation is an essential component of the protective response to fungi, its dysregulation may significantly worsen fu... | 18,802,343 |
Definition and classification of acute kidney injury. | Changes in urine output and glomerular filtration rate are neither necessary nor sufficient for the diagnosis of renal pathology. Yet no simple alternative for the diagnosis currently exists. Until recently, there has been no consensus as to diagnostic criteria or clinical definition of acute renal failure. Depending o... | 18,802,365 |
The bioartificial kidney and bioengineered membranes in acute kidney injury. | The treatment of severe acute kidney injury (AKI) with dialysis or hemofiltration remains suboptimal with high levels of morbidity and mortality. Current renal replacement therapies substitute for the small solute clearance function of the kidney but do not replace the lost reclamation, metabolic and endocrine function... | 18,802,374 |
c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. | Overexpression of the c-myc oncogene frequently occurs in both colon tumors and colon carcinoma cell lines. We examined the sensitization of human colorectal cancer cells to chemotherapeutic drugs using c-myc antisense (AS) phosphorothioate oligonucleotides ([S]ODNs). Cancer cells were treated with c-myc [S]ODNs, taxol... | 18,802,399 |
Monitoring the rate of hospitalization before rotavirus immunization in Italy utilizing ICD9-CM regional databases. | Recently, two Rotavirus (RV) vaccines were licensed in Italy, rendering RV illness a vaccine preventable disease. To assess the RV hospitalization rate in Italy, a study focused on the Regional hospital discharge forms (HDD) databases was carried out. Regional HDD databases from Piemonte, Veneto, Friuli-Venezia-Giulia ... | 18,802,404 |
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. | Neddylation is the post-translational protein modification that is most closely related to ubiquitination. However, ubiquitination is known to regulate a myriad of processes in eukaryotic cells, whereas only a limited number of neddylation substrates have been described to date. Here, we review the principles of protei... | 18,802,447 |
Modeling recursive RNA interference. | An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo. In several published experiments, RNAi has been used to inactivate components of the RNAi pathway itself, a procedur... | 18,802,453 |
Computational structural analysis: multiple proteins bound to DNA. | With increasing numbers of crystal structures of proteinratioDNA and proteinratioproteinratioDNA complexes publically available, it is now possible to extract sufficient structural, physical-chemical and thermodynamic parameters to make general observations and predictions about their interactions. In particular, the p... | 18,802,470 |
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. | Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after injury. Activation of the hedgehog (Hh) signaling pathway regulates EMT during development. This pathway is also induced... | 18,802,480 |
Click chemistry step growth polymerization of novel alpha-azide-omega-alkyne monomers. | A novel step growth polymerization A-B strategy based on the click chemistry polyaddition of tailor-made alpha-azide-omega-alkyne low molar mass monomers was developed, leading to polytriazole (co)polymers with tunable structures and properties. | 18,802,508 |
Multiple molecular logic functions and molecular calculations facilitated by surfactant's versatility. | Two isomeric compounds and , combining intramolecular charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms together, were designed and used as logic gates with configurable multiple outputs; ten different logic functions (AND, NAND, OR, NOR, XNOR, INHIBIT, YES, NO, PASS 1 and PASS 0) were achieved ... | 18,802,509 |
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