title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastoma cells via paxillin. | Previously, we reported that phorbol 12-myristate 13-acetate (PMA)-activated protein kinase C (PKC) induced Rac1 activation in A172 glioblastoma cells. In this study, we investigated the mechanism of PMA-activated PKC-induced migration of glioblastoma cells by focusing on Rac1. PMA-induced formation of lamellipodia and... | 18,813,807 |
Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma. | Angiogenesis is an essential process for progression of hepatocellular carcinoma (HCC). The Akt-mTOR-p70S6K signal pathway has been recognized for its roles in regulating neoangiogenesis. The role of activation of the pathway in HCC progression is poorly understood. This study aimed to evaluate the immunohistochemical ... | 18,813,808 |
Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. | Yanhusuo (Corydalis yanhusuo W.T. Wang) is a well-known traditional Chinese medicine (TCM). In this study, we attempted to characterize in detail the signaling cascades that produce its anti-metastatic effect on the human breast cancer cell line, MDA-MB-231. We found that the yanhusuo extract inhibited the migration an... | 18,813,823 |
Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma. | Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been observed in many human malignancies. Using the sequence-specific RNA interference (RNAi) method to switch off Stat3 expression, it may be possible to arrest cancer growth. In this study, we aimed to identify the most effectiv... | 18,813,829 |
Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells. | This study aimed to investigate the role of the cytoskeleton-associated protein vasodilator-stimulated phosphoprotein (VASP) on the migration and invasion of human breast cancer cells and its relationship to Rac1 which is a member of the Rho family and has been found to be implicated in tumorigenesis, invasion and meta... | 18,813,837 |
Urokinase-type plasminogen activator receptor is associated with macrophages and plaque rupture in symptomatic carotid atherosclerosis. | There is a strong correlation between macrophage infiltration and plaque instability in recently symptomatic carotid atherosclerotic plaques, and it is hypothesised that mechanisms related to macrophages may be involved in plaque vulnerability and rupture. We previously found high expression of urokinase-type plasminog... | 18,813,852 |
Evaluation of novel cyclic analogues of apelin. | Apelin regulates various cell signaling processes through interaction with its specific cell-surface receptor, APJ, which is a member of a seven transmembrane G protein-coupled receptor superfamily. To develop a novel apelin analogue, we synthesized cyclic analogues of minimal apelin fragment RPRLSHKGPMPF (apelin-12), ... | 18,813,863 |
Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii. | Coxiella burnetii is an obligate intracellular bacterial pathogen that causes the zoonosis Q fever. While an effective whole-cell vaccine (WCV) against Q fever exists, the vaccine has limitations in being highly reactogenic in sensitized individuals. Thus, a safe and effective vaccine based on recombinant protein antig... | 18,813,881 |
Anticoagulant and/or antiplatelet treatment in patients with atrial fibrillation after percutaneous coronary intervention. A single-center experience. | Atrial fibrillation (AF) is the most common cardiac arrhythmia sustained and frequently occurs in patients with coronary heart disease. Thus, a large number of patients requiring percutaneous coronary intervention (PCI) also suffer from AF. An anticoagulant regimen has not been standardized for patients with AF after c... | 18,813,885 |
Physiotherapy does not prevent, or hasten recovery from, ventilator-associated pneumonia in patients with acquired brain injury. | To investigate the effect of respiratory physiotherapy on the prevention and treatment of ventilator-associated pneumonia (VAP) for adults in an intensive care unit (ICU) with an acquired brain injury (ABI). Two-part, prospective, randomised controlled trial. A total of 144 subjects with ABI admitted with a Glasgow Com... | 18,813,910 |
Endoscopic third ventriculostomy: the best option in the treatment of persistent hydrocephalus after posterior cranial fossa tumour removal? | Ten to 40% of children operated on for a posterior fossa tumour require a further surgical procedure for the management of a persisting active ventricular dilation. The management of this kind of hydrocephalus is still controversial. To prospectively evaluate the effectiveness of post-operative endoscopic third ventric... | 18,813,936 |
Identification of SLC26A4 gene mutations in Iranian families with hereditary hearing impairment. | Mutations in the SLC26A4 gene at the DFNB4 locus are responsible for Pendred syndrome and non-syndromic hereditary hearing loss (DFNB4). This study included 80 nuclear families with two or more siblings segregating presumed autosomal recessive hearing loss. All deaf persons tested negative for mutations in GJB2 at the ... | 18,813,951 |
New data on ectomycorrhizae and soils of the Chinese truffles Tuber pseudoexcavatum and Tuber indicum, and their impact on truffle cultivation. | Chinese truffles serve as a good complement to the market for Tuber melanosporum (Périgord black truffle). However, Chinese truffles could be introduced accidentally or fraudulently into the plantations of Mediterranean truffles, and they could have a negative effect on truffle production and natural ecosystems. The st... | 18,813,959 |
Expert benchmark for the GI Mentor II. | There is increasing interest in the use of virtual-reality simulators in general surgery residency training. Many simulators lack a benchmark against which trainees can measure competence and skill. Surgeons who had performed over 1,000 colonoscopies were evaluated on module 1, case 5 of the GI Mentor I or II virtual-r... | 18,813,977 |
What is going on in augmented reality simulation in laparoscopic surgery? | To prevent unnecessary errors and adverse results of laparoscopic surgery, proper training is of paramount importance. A safe way to train surgeons for laparoscopic skills is simulation. For this purpose traditional box trainers are often used, however they lack objective assessment of performance. Virtual reality lapa... | 18,813,987 |
Sexual function after sacrospinous fixation for vaginal vault prolapse: bad or mad? | The main indication for sacrospinous ligament suspension is to correct either total procidentia, a posthysterectomy vaginal vault prolapse with an associated weak cardinal uterosacral ligament complex, or a posthysterectomy enterocele. This study aimed to evaluate sexual function and anatomic outcome for patients after... | 18,814,009 |
Proteomic analysis of mammary tissues from healthy cows and clinical mastitic cows for identification of disease-related proteins. | To investigate the disease-related proteins and understand molecular mechanism of mastitis at the protein level, this project presents the protein changes in the mammary gland between healthy cows and clinical mastitic cows using two-dimensional gel electrophoresis (2-DE), after stained with colloidal Coomassie Bright ... | 18,814,050 |
[Winter sports and shoulder arthroplasty]. | Nowadays, a general negative evaluation of sportive activity regarding different kinds of sport following arthroplasty is at present no more scientifically supported. However, at present no valid guidelines regarding sportive activity of patients after implantation of shoulder joint arthroplasty exist. The question reg... | 18,814,057 |
[Damping inserts have no load reducing effect in the fatigued state]. | Overload injuries to the lower limbs may be attributed to repetitive, non-physiological load stimuli. However, these impact loads acting on the musculoskeletal can be reduced by wearing damping inserts. To date, however, there is only little evidence as to whether this positive effect can be assigned to the damping ins... | 18,814,060 |
Hepatic vascular malformations in hereditary hemorrhagic telangiectasia. | Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder that can involve the liver diffusely in the form of vascular malformations ranging from small telangiectases to discrete arteriovenous malformations. Anatomically, three different patterns of abnormal vascular communications can occu... | 18,814,078 |
[Combination therapy in patients with pulmonary arterial hypertension]. | Despite recent remarkable efforts in the medical treatment options of patients with pulmonary arterial hypertension (PAH) a considerable number of patients need escalations to improve disease related symptoms and pulmonary hemodynamics. Most of the pulmonary vascular vasodilators have been approved in its potency as an... | 18,814,093 |
[Decompensated pulmonary hypertension]. | Right ventricular failure may result from an newly developed disease (e.g. as a consequence of acute respiratory distress syndrome [ARDS] or of severe pulmonary embolism) or of already present pulmonary hypertension (PHT). There is as yet no generally recognized definition of acute or chronic right ventricular failure.... | 18,814,101 |
[Assessment of the solid-liquid behavior of the liver for the diagnosis of diffuse disease using magnetic resonance elastography]. | Recent magnetic resonance elastography (MRE) studies have reported the potential of this noninvasive method for diagnosing hepatic fibrosis based on the elastic properties of liver tissue. However, in many cases biological tissue responds to mechanical vibrations as a combined solid-liquid body causing MRE-derived elas... | 18,814,103 |
[Neurogenic communication disorders: how effective are relaxation therapy and acupuncture?]. | Not only neurologists but also ENT-physicians and phoniatricians have to prescribe speech and language therapy for patients with communication disorders. Complementary and alternative medicine (CAM) has gained increasing popularity among patients. Many studies have investigated these procedures and positive effects on ... | 18,814,104 |
Iliocaval arteriovenous fistula following lumbar disc surgery: endovascular treatment with a Stent-graft. | Arteriovenous (AV) fistulae, pseudoaneurysms, and lacerations may occur during disc surgery. AV fistula after lumbar disc surgery is rare. Early diagnosis and treatment of vascular complications associated with disc surgery is essential due to their high mortality and morbidity rates. We report a case report who was pr... | 18,814,112 |
A large choroid plexus papilloma removed by the cerebellomedullary fissure approach. Case report and review of the literature. | We report a case of large choroid plexus papilloma of the fourth ventricle in a 23-year-old woman. She presented with severe headache, dysphagia, and gait disturbances. Horizontal nystagmus, ataxic gait and quadriparesis were detected on initial examination. Imaging studies showed a large mass in the left side of brain... | 18,814,123 |
Multiplexed lipid dip-pen nanolithography on subcellular scales for the templating of functional proteins and cell culture. | Molecular patterning processes taking place in biological systems are challenging to study in vivo because of their dynamic behavior, subcellular size, and high degree of complexity. In vitro patterning of biomolecules using nanolithography allows simplification of the processes and detailed study of the dynamic intera... | 18,814,174 |
Iron deficiency anemia and affective response in rhesus monkey infants. | Infant iron deficiency anemia (IDA) occurs spontaneously in monkey populations as it does in humans, providing a model for understanding effects on brain and behavior. A set of 34 monkey infants identified as IDA (hemoglobin <11 g/dl) over a 5-year period at the California National Primate Research Center (CNPRC) wa... | 18,814,183 |
Long-term sustained benefits of clozapine treatment in refractory early onset schizophrenia: a retrospective study in Korean children and adolescents. | Treatment resistance in early onset schizophrenia (EOS) is one of the most challenging problems in child and adolescent psychiatry. We retrospectively examined the therapeutic dosage, clinical response, and side effect profiles of long-term clozapine treatment in Korean children and adolescents with refractory EOS or v... | 18,814,190 |
Separation of flavins and nicotinamide cofactors in Chinese hamster ovary cells by capillary electrophoresis. | Simultaneous extraction, separation and quantitation of reduced nicotinamide adenine dinucleotide (NADH), reduced nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) in Chinese Hamster Ovary (CHO) cells were investigated. The separation of flavins and n... | 18,814,195 |
Optimizing high-performance liquid chromatography method for quantification of glucosamine using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate derivatization in rat plasma: application to a pharmacokinetic study. | A sensitive and reliable HPLC method with fluorescence detection based on the precolumn derivatization of glucosamine with 6-aminoquinolyl-N-hydroxylsuccinimidyl carbamate (AQC) was established for the quantitative determination of glucosamine in rat plasma. The plasma protein was precipitated by acetonitrile, followed... | 18,814,196 |
Techniques for chorionic villus sampling and amniocentesis: a survey of practice in specialist UK centres. | Guidelines exist for amniocentesis and chorionic villous sampling (CVS) practice, but there is no consensus regarding individual techniques. Our survey sought to review current practice within specialist centres in the United Kingdom. RCOG sub-specialist training centres were invited to complete a postal questionnaire,... | 18,814,215 |
ROCKs are expressed in brain tumors and are required for glioma-cell migration on myelinated axons. | The interactions between migrating glioma cells and myelinated fiber tracts are poorly understood. We identified that C6 glioma cells can migrate along myelinated chicken retinal axons in a novel coculture, thereby expressing small GTPases of the Rho family and serine/threonine Rho-associated kinases (ROCKs). We found ... | 18,814,230 |
mRNAs of tyrosine hydroxylase and dopa decarboxylase but not of GD2 synthase are specific for neuroblastoma minimal disease and predicts outcome for children with high-risk disease when measured at diagnosis. | Several transcripts have been claimed to be clinically valuable for detecting minimal disease in neuroblastoma, but they have not been prospectively compared in a standardized manner. Tyrosine hydroxylase (TH), dopa decarboxylase (DDC) and GD2 synthase (GD2S) mRNAs were analyzed in 554 blood (PB) and bone marrow (BM) s... | 18,814,238 |
Intrafamilial transmission of hepatitis C virus: infection of the father predicts the risk of perinatal transmission. | The aims of the present study were to evaluate in a cohort of mothers infected with hepatitis C virus (HCV) the prevalence of HCV infection of their sexual partners, the influence of infection of the partners on perinatal transmission, and whether this influence is mediated by other well known risk factors for perinata... | 18,814,243 |
Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage. | Polymeric medical devices widely used in orthopedic surgery play key roles in fracture fixation and orthopedic implant design. Topographical modification and surface micro-roughness of these devices regulate cellular adhesion, a process fundamental in the initiation of osteoinduction and osteogenesis. Advances in fabri... | 18,814,275 |
Modified Escherichia coli B (BL21), a superior producer of plasmid DNA compared with Escherichia coli K (DH5alpha). | Plasmid DNA (pDNA) is an emerging experimental vaccine, produced in E. coli, initially targeted for viral diseases. Unlike traditional protein vaccines whose average dose is micrograms, the average dose of pDNA is on the scale of milligrams. Production yields are, therefore, important for the future development of this... | 18,814,292 |
Convective-diffusive mass transfer of agonist and the intracellular calcium response of endothelial cell. | Endothelial cell layer regulates several crucial physiological processes of the vascular system. The mechanism of the response of this cell layer to the flow of surrounding fluid is still largely unclear. In the present article, a comparison of the available experimental results for the intracellular calcium ion concen... | 18,814,294 |
Functional differentiation of a clone resembling embryonic cortical interneuron progenitors. | We have generated clones (L2.3 and RG3.6) of neural progenitors with radial glial properties from rat E14.5 cortex that differentiate into astrocytes, neurons, and oligodendrocytes. Here, we describe a different clone (L2.2) that gives rise exclusively to neurons, but not to glia. Neuronal differentiation of L2.2 cells... | 18,814,314 |
Molecular interactions of isoxazolcurcumin with human serum albumin: spectroscopic and molecular modeling studies. | Curcumin is a nontoxic natural product with diverse pharmacological potencies. We report the interaction of a potent synthetic derivative of curcumin, isoxazolcurcumin (IOC) with human serum albumin (HSA) using various biophysical methods. The observed fluorescence quenching of HSA by IOC is due to a complex formation ... | 18,814,316 |
Proteomic analysis of alterations in the secretome of Arabidopsis thaliana suspension cells subjected to nutritional phosphate deficiency. | A proteomic approach was applied to compare the secretome (culture filtrate proteome) of phosphate-sufficient (+Pi) and Pi-deficient (-Pi) Arabidopsis thaliana suspension cell cultures. Secretomes harvested from the +Pi and -Pi cells yielded dissimilar 2-DE maps. PMF via MALDI-TOF MS resulted in the identification of 5... | 18,814,331 |
Parameatal urethral cyst. | Cyst formation in the parameatal area of the urethra is an uncommon entity. It was first reported in two male cases as recently as 1956 by Thompson and Lantin. Further reports have been rare. Herein, we report a case of a 21 year-old male having a spherical, cystic swelling 1 cm in size at the external urethral meatus.... | 18,814,338 |
Knowledge, beliefs and attitudes about HIV/AIDS-related issues, and the sources of knowledge among health care professionals in southern Nigeria. | The HIV/AIDS pandemic has become one of the most important public health problems in recent times and it is having a profound impact on the lives of infected people and their families. There is an acknowledged burden of HIV/AIDS in Nigeria. As the prevalence of HIV/AIDS infection rises, health care professionals worldw... | 18,814,404 |
Workplace wellness programs in Canada: an exploration of key issues. | Faced with the reality of rising health costs, Canadian employers are thinking beyond traditional notions of responsibility for employee health and have begun to embrace Workplace Wellness Programs (WWPs). This article investigates the critical issues of WWPs in the Canadian context from the perspective of key stakehol... | 18,814,425 |
Single parameter wrist ultrasonography as a first-line screening examination in suspected carpal tunnel syndrome patients. | Carpal tunnel syndrome (CTS) is the most common form of peripheral nerve entrapment. Electromyography with selected nerve conduction studies (NCS) is an accepted diagnostic tool in CTS patients. Ultrasonography presents a widely available and low cost investigation method and its position in CTS diagnostics needs furth... | 18,814,435 |
Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life. | Prevalence of asthma in developed countries increased between the 1970s and the 1990s. One factor that might contribute to the trends in asthma is the increased use of acetaminophen vs aspirin in children and pregnant women. To examine relationships between in utero exposure to acetaminophen and incidence of respirator... | 18,814,450 |
Cost-effectiveness of specific subcutaneous immunotherapy in patients with allergic rhinitis and allergic asthma. | Specific immunotherapy is the only potentially curative treatment in patients with allergic rhinitis and allergic asthma. Health economic evaluations on this treatment, particularly in a German context, are sparse. To evaluate the cost-effectiveness of specific subcutaneous immunotherapy (SCIT) in addition to symptomat... | 18,814,456 |
Basic science for the practicing physician: gene expression microarrays. | To provide a general overview of gene expression microarray technology and its relevance to physicians practicing allergy/immunology. The PubMed interface to MEDLINE was searched for primary and review articles on gene expression microarrays. Specific articles on clinical applications of microarrays were retrieved, alo... | 18,814,457 |
Depth of facial expression processing depends on stimulus visibility: behavioral and electrophysiological evidence of priming effects. | Participants performed a priming task during which emotional faces served as prime stimuli and emotional words served as targets. Prime-target pairs were congruent or incongruent, and two levels of prime visibility were obtained by varying the duration of the masked primes. To probe a neural signature of the impact of ... | 18,814,465 |
Venous access in oncology and haematology patients: Part two. | To assess the validity and inter-rater reliability of two tools, Venous Assessment Tool (VAT) and Deciding on IntraVenous Access (DIVA), using thematic analysis of feedback from nurses who used the tools, Analysis methods used in grounded theory were employed to investigate the written feedback provided by nurses. Inte... | 18,814,475 |
[Lucentis versus Avastin--is there a light at the end of the tunnel for age-related macular degeneration patients?]. | Age-related macular degeneration is the leading cause of blindness and visual impairment in the developed world. The recently introduced anti-vascular endothelial growth factor (VEGF) intravitreal injections of Ranibizumab (Lucentis) and Bevacizumab (Avastin) generated a heated academic argument: on the one hand Lucent... | 18,814,519 |
[Cancer-related lymphedema in Israel]. | Lymphedema, the accumulation of protein-rich fluid in an involved extremity or other body part, is a chronic life-long condition following many types of surgical procedures, most often breast cancer surgical therapy. The patient suffering from lymphedema faces difficult medical, social, psychological and aesthetic issu... | 18,814,523 |
[Anxiety disorders in children and adolescents]. | Anxiety disorders are the most common psychiatric illnesses in children and adolescents. They are associated with significant distress and impairment. Most of the children and adolescents with anxiety disorders are not detected and only a minority receives adequate treatment. Anxious children and adolescents often foll... | 18,814,524 |
Factors influencing the use of episiotomy during vaginal delivery in South Eastern Nigeria. | Given considerable evidence that routine episiotomy increases maternal morbidity and without evidence to support maternal or neonatal benefit, has episiotomy use changed among health care providers? To date, very limited information exists relating to the past and current practice of episiotomy in many developing count... | 18,814,534 |
Myxidium scripta n. sp. identified in urinary and biliary tract of Louisiana-farmed red-eared slider turtles Trachemys scripta elegans. | During a necropsy investigation of a mortality event occurring at a turtle farm in Assumption Parish, Louisiana, spores of a myxozoan were identified in the renal tubules in 3 of 6, the gall bladder lumen in 2 of 6, and the bile ductule in 1 of 6 red eared slider turtles Trachemys scripta elegans. In total, myxozoa wer... | 18,814,545 |
Gambling: normal adolescent activity or pathologic addiction? | A 15-year-old comes to the school counselor. He owes $4,000 in gambling debts to a sports-betting bookie, and he doesn't have the money. He is afraid. Yet, 2 weeks later, he bet on the Super Bowl and won $3,000. A 14-year-old limits his betting to $20 and $30; he only bets what he has and he is happy with his successes... | 18,814,567 |
Ethical perspectives of children's assent for research participation: deontology and on utilitarianism. | Is a child's assent to participate in research that does not have the potential to directly benefit the child ethically mandated? Analysis of this particular dilemma of health care research in children using two competing theories results in different answers. Deontology (principle-based ethics) will be contrasted with... | 18,814,566 |
Horizontal distribution and levels of heavy metals in the biggest snowstorm in a century in Shenyang, China. | The horizontal distribution and levels of heavy metals in the biggest snowstorm in Shenyang since 1904 were investigated by analyzing 4 metals (As, Cd, Pb, and Cu) in a series of ultraclean samples collected from 17 sites distributed in different regions of the Shenyang area, China. The results showed that the concentr... | 18,814,581 |
Location and PCR analysis of catabolic genes in a novel Streptomyces sp. DUT_AHX capable of degrading nitrobenzene. | A novel strain of Streptomyces sp. DUT_AHX was isolated from sludge contaminated with nitrobenzene and identified on the basis of physiological and biochemical tests and 16S ribosomal DNA (rDNA) sequence analysis. The optimal degradation conditions were as follows: temperature 30 degrees C, pH 7.0-8.0, shaking speed 15... | 18,814,584 |
Combined team training. | For professions that operate in dynarnic environments, developing and improving team performance is a significant issue. Paramedics often utilize advanced, high-risk, low-frequency clinical procedures such as endotracheal intubation, rapid sequence induction, needle chest decompression and surgical airways. These proce... | 18,814,639 |
Environmental parameters affecting the species diversity along the Aliakmon River, North Greece. | The annual distribution of aquatic and coastal macrophytes in five selected sites along the Aliakmon River was studied from January 2005 to December 2005 in Northern Greece. Soil and water chemical parameters in these sites were also evaluated. A total of 75 taxa were recorded belonging to 37 families and 53 genera. Th... | 18,814,647 |
Abiotic transmission of Rice yellow mottle virus through soil and contact between plants. | The roles of guttation fluid, irrigation water, contact between plants and transplantation into contaminated soil in the transmission of Rice yellow mottle virus (RYMV) were assessed. RYMV presence and infectivity were tested by Enzyme-Linked Immunosorbent Assay (ELISA) and by inoculation to susceptible rice cultivar B... | 18,814,653 |
Prevalence of hypertension among Iranian hemodialysis patients and associated risk factors: a nationwide multicenter study. | The aim of this study is to document the prevalence of HTN and characterize risk factors associated with HTN in Iranian hemodialysis patients. Three hundred and thirty seven HD patients from 5 university based HD centers around Iran were enrolled in the study. Urea reduction ratio was calculated using formula: 100 * (1... | 18,814,655 |
Pregnancy rate following transfer of in vitro produced lamb derived embryos in two embryonic stages. | Ovine embryos were produced by maturation, fertilization and in vitro culture (IVM/IVF/IVC) of oocytes collected from slaughtered prepubertal ewes. At 24 h post IVM, oocytes were fertilized with fresh semen collected from Lori-Bakhtiari breed at a concentration of 1.0 x l0(6) sperm mL(-1). The presumptive ova/embryos w... | 18,814,661 |
Callogenic studies of Achyranthes aspera leaf explant at different hormonal combinations. | With the objective to promote in vitro callus induction, leaf segments of Achyranthes aspera were inoculated on basal MS medium supplemented with 3.0% sucrose and 0.8% agar with different concentrations of 2,4-D alone and in combination with NAA, BAP, IAA, IBA and Zeatin. The explants were maintained in growth room at ... | 18,814,664 |
Backbreaking work. What you need to know about lifting and back safety in EMS. | Geraldine did not look very heavy, but she was wedged between the toilet and bath-tub. She had slipped while getting out of the tub and was complaining of severe hip pain. The room was only big enough for me, my partner and Geraldine, who needed to be lifted up and out of the room to the cot in the hallway. The questio... | 18,814,673 |
Cellular and molecular interactions between the apicomplexan parasites Plasmodium and Theileria and their host cells. | Apicomplexan parasites of the genera Theileria and Plasmodium have complicated life cycles including infection of a vertebrate intermediate host and an arthropod definitive host. As the Plasmodium parasite progresses through its life cycle, it enters a number of different cell types, both in its mammalian and mosquito ... | 18,814,683 |
Pathophysiology of enteric infections with Giardia duodenalius. | Giardia is the most prevalent human intestinal parasitic protist in the world, and one of the most common parasite of companion animals and young livestock. Giardia is a major cause of diarrhea in children and in travelers. The host-microbial interactions that govern the outcome of infection remain incompletely underst... | 18,814,692 |
Penetration of Trichobilharzia cercariae into mammals: dangerous or negligible event? | Bird schistosomes and cases of human cercarial dermatitis occur worldwide, but the number of cases is not monitored. Experiments with two schistosomes, namely Trichobilharzia szidati and T. regenti, show that they possess potent tools to penetration bird and mammalian skin, as well as exhibit species-specific migration... | 18,814,698 |
Environmental parasitology. Interactions between parasites and pollutants in the aquatic environment. | In recent years there has been an increasing number of papers showing how parasitism and pollution can interact with each other in aquatic organisms. Among the variety of investigated aspects especially the combined effects of pollution and simultaneous infection on the health of aquatic hosts (molluscs, crustaceans, f... | 18,814,718 |
Parasite co-structure: broad and local scale approaches. | A co-structure study is a comparison of demographic and/or genetic structure between two or more species. Such a comparative analysis among a parasite and its host(s) or among multiple parasite species is useful to elucidate factors that shape genetic variation within and among parasite populations. I provide a brief r... | 18,814,719 |
The population genetic structure of vectors and our understanding of disease epidemiology. | Understanding and predicting disease epidemiology relies on clear knowledge about the basic biology of the organisms involved. Despite the key role that arthropod vectors play in disease dynamics and detailed mechanistic work on the vector-pathogen interface, little information is often available about how these popula... | 18,814,720 |
Manson's triple error. | The author discusses the significance, implications and limitations of Manson's work. How did Patrick Manson resolve some of the major problems raised by the filarial worm life cycle? The Amoy physician showed that circulating embryos could only leave the blood via the percutaneous route, thereby requiring a bloodsucki... | 18,814,729 |
[What is the purpose of dual or triple inhibition of the renin-angiotensin-aldosterone system?]. | The blockade of the renin-angiotensin-aldosterone system (RAAS) is helpful in the management of arterial hypertension, congestive heart failure, post-myocardial infarction and diabetic nephropathy. Such blockade can be obtained with an angiotensin converting enzyme inhibitor, a specific antagonist of angiotensin II AT1... | 18,814,762 |
[CB1 receptor inhibition and glucose metabolism: role of rimonabant in type 2 diabetes]. | Endocannabinoid system is overactivated in individuals with abdominal obesity. CBI receptors, first individualized in the brain, are also expressed in the adipocyte, the skeletal muscle, the liver, the gut, and the pancreas. Their blockade improves glucose tolerance and lipid profile, thanks increased insulin sensitivi... | 18,814,765 |
[Clinical effects of biapenem on febrile neutropenia in patients with hematological malignancy]. | Recent advances in the treatment of hematological malignancies often induce febrile neutropenia (FN) due to severe myelosuppression. The aim of this study was to evaluate the safety and efficacy of biapenem in such FN. Candidate patients were admitted to our hospital and were treat of their hematological malignancy fro... | 18,814,798 |
New developments in anticoagulation for atrial fibrillation. | The incidence of stroke in patients with atrial fibrillation (AF) is five times greater than that in age-matched controls. Warfarin reduces this incidence by two thirds and is the most effective agent for this indication. However, despite its efficacy, warfarin management is tedious and is useful only in a subsegment o... | 18,814,828 |
Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos. | The de novo DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of DNA methylation patterns in mouse development. Dnmt3b is more highly expressed in early developmental stages than Dnmt3a, and is thought to have an important role in the epigenetic gene regulation during early embryogenesis. Prev... | 18,814,855 |
Improved odor sensitivity in attention-deficit/hyperactivity disorder. | Deficits in olfactory function are common features in neurodegenerative and neuropsychiatric disorders. In Parkinson's disease, olfactory deficits were found in up to 90% of patients, and there is evidence for dopaminergic dysfunction underlying these deficits. Because of the involvement of the dopamine system in the p... | 18,814,862 |
Improved method for fatty acid analysis in herbage based on direct transesterification followed by solid-phase extraction. | Direct transesterification (DT) and solvent extraction with acid or basic derivatization procedure for fatty acid (FA) analysis in herbage were compared. The highest total FA, alpha-linolenic and linoleic acid contents were obtained with DT. However, DT also produced the highest amount of interfering compounds, identif... | 18,814,883 |
Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. | Cholesterol present in the plasma membrane of target cells has been shown to be important for the infection by SARS-CoV. We show that cholesterol depletion by treatment with methyl-beta-cyclodextrin (m beta CD) affects infection by SARS-CoV to the same extent as infection by vesicular stomatitis virus-based pseudotypes... | 18,814,896 |
Treatment of PAHs in contaminated soil by extraction with aqueous DNA followed by biodegradation with a pure culture of Sphingomonas sp. | The biodegradation of polycyclic aromatic hydrocarbons (PAHs) in aqueous deoxyribonucleic acid (DNA) solution from contaminated soil washing was investigated. Initial data with a model effluent consisting of anthracene, phenanthrene, pyrene and benzo[a]pyrene that were individually dissolved in 1% aqueous DNA solution ... | 18,814,900 |
Concentrations and fluxes of dissolved organic carbon in UK topsoils. | Dissolved organic carbon (DOC) concentrations in soil water samples collected from depths of 5 to 20 cm at 10 moorland and 11 forest sites during the period 2000-2006 were obtained from new measurements and from the monitoring programmes of the UK Environmental Change Network and the International Cooperative Programme... | 18,814,901 |
Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. | TRPA1, a Ca(2+)-permeable cation channel that is expressed in sensory neurones, is involved in the perception of chemical irritants and mechanical hyperalgesia. TRPA1 is activated by either covalent or reversible binding of various chemical compounds, including allylisothiocyanate or acrolein, and is further sensitised... | 18,814,910 |
Effect of polymyxin B and environmental conditions on isolation of Brucella species and the vaccine strain RB51. | Brucella are resistant to polymyxin B (PB), but their relative susceptibility to PB and its derivative, colistin (COL) has not been rigorously or systematically studied. Comparative susceptibility of Brucella reference strains, vaccine strain RB51, and Brucella isolates from marine mammals to these two cationic peptide... | 18,814,911 |
Reversing opinions on Dollo's Law. | Dollo's Law, the idea that the loss of complex features in evolution is irreversible, is a popular concept in evolutionary biology. Here we review how application of recent phylogenetic methods, genomics and evo-devo approaches is changing our view of Dollo's Law and its underlying mechanisms. Phylogenetic studies have... | 18,814,933 |
Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients. | In this study, we sought to evaluate the prognostic importance of chromosomal instability (CIN) in adenocarcinoma (AC) of the lung. The relationship between CIN detected by fluorescence in situ hybridization (FISH) and survival in AC patients was examined. Sixty-three surgical specimens of lung AC were analyzed. To ide... | 18,814,932 |
Antinociceptive effect of resveratrol in carrageenan-evoked hyperalgesia in rats: prolonged effect related to COX-2 expression impairment. | Resveratrol is a natural polyphenol that protects from cancer and cardiovascular diseases. Resveratrol is able to induce apoptotic cell death and it inhibits the cyclooxygenase (COX) cascade. We measured the antinociceptive effect of resveratrol on carrageenan-induced hyperalgesia, prostaglandin-E2 (PGE2) concentration... | 18,814,970 |
Reduced Sertoli cell number and altered pituitary responsiveness in male lambs undernourished in utero. | The nutritional status of females during pregnancy can have profound effects on the fetus reproductive system development that could affect the reproductive potential as later as in adulthood (fetal programming). The aim of the present study was to examine the effects of maternal nutrient restriction imposed during dif... | 18,814,977 |
A simple and rapid high-performance liquid chromatographic method for the determination of bisoprolol fumarate and hydrochlorothiazide in a tablet dosage form. | A simple and precise high performance liquid chromatographic method has been developed and validated for the simultaneous determination of bisoprolol fumarate (BF), and hydrochlorothiazide (HCTZ) in a tablet formulation. Chromatography was carried out at 25 degrees C on a 4.6 mm x 250 mm, 5 microm cyano column with the... | 18,814,989 |
Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency Department. | Serum lactate levels are a useful tool in monitoring critically ill patients, especially those who are septic. However, lactate levels are often not routinely drawn or rapidly available in some institutions. The objective of this study was to determine if a readily available anion gap (AG) could be used as a surrogate ... | 18,815,002 |
Willow bark extract (Salicis cortex) for gonarthrosis and coxarthrosis--results of a cohort study with a control group. | The examination of the effectiveness and tolerance of willow bark extract in patients with gonarthrosis and coxarthrosis compared to conventional therapies. In an open, multicentric observational study with reference treatment, 90 patients were treated with a standardised willow bark extract preparation, 41 patients wi... | 18,815,018 |
Achieving asthma control in practice: understanding the reasons for poor control. | Achieving asthma control remains an elusive goal for the majority of patients worldwide. Ensuring a correct diagnosis of asthma is the first step in assessing poor symptom control; this requires returning to the basics of history taking and physical examination, in conjunction with lung function measurement when approp... | 18,815,019 |
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. | An imidazole series of cyclin-dependent kinase (CDK) inhibitors has been developed. Protein inhibitor structure determination has provided an understanding of the emerging structure activity trends for the imidazole series. The introduction of a methyl sulfone at the aniline terminus led to a more orally bioavailable C... | 18,815,031 |
Needle in the haystack: structure-based toxin discovery. | In the current data-rich era, making the leap from sequence data to knowledge is a task that requires an elegant bioinformatics toolset to pinpoint pressing research questions. Therefore, a strategy to expand important protein-family knowledge is required, particularly in cases in which primary sequence identity is low... | 18,815,047 |
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers. | DZ2002 and its related stereoisomers were efficiently synthesized. The optical data of (R)- and (S)-DZ2002 were disclosed here for the first time. Their inhibitory potency was evaluated on SAHase and MLR assay in the mean time. In accordance with respective inhibitory potency of SAHase, the immunosuppressive potency or... | 18,815,049 |
Solid state water motions revealed by deuterium relaxation in 2H2O-synthesized kanemite and 2H2O-hydrated Na+-zeolite A. | Deuterium NMR relaxation experiments, low temperature deuterium NMR lineshape analysis, and FTIR spectra are consistent with a new model for solid state jump dynamics of water in (2)H(2)O-synthesized kanemite and (2)H(2)O-hydrated Na(+)-Zeolite A. Exchange occurs between two populations of water: one in which water mol... | 18,815,060 |
A case of Staphylococcus saccharolyticus pneumonia. | This paper reports a case of a very rare and dangerous disease, Staphylococcus saccharolyticus pneumonia. In this tragic case, a 21-year-old patient died after he did not receive timely diagnosis and proper treatment. | 18,815,064 |
Development and validation of a LC/MS/MS method for quantifying the next generation calcineurin inhibitor, voclosporin, in human whole blood. | A rapid, accurate, and reproducible liquid chromatography electrospray tandem mass spectrometry (LC/ESI-MS/MS) method was developed and validated for the therapeutic drug monitoring of voclosporin in human whole blood. Sample aliquots of 100muL were processed utilizing a protein precipitation procedure that contained a... | 18,815,080 |
A 4-channel coil array interconnection by analog direct modulation optical link for 1.5-T MRI. | Optical glass fiber shows great advantages over coaxial cables in terms of electromagnetic interference, thus, it should be considered a potential alternative for magnetic resonance imaging (MRI) receive coil interconnection, especially for a large number coil array at high field. In this paper, we propose a 4-channel ... | 18,815,095 |
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