title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Analysis of fMRI data using improved self-organizing mapping and spatio-temporal metric hierarchical clustering. | The self-organizing mapping (SOM) and hierarchical clustering (HC) methods are integrated to detect brain functional activation; functional magnetic resonance imaging (fMRI) data are first processed by SOM to obtain a primary merged neural nodes image, and then by HC to obtain further brain activation patterns. The con... | 18,815,099 |
Efficient segmentation by sparse pixel classification. | Segmentation methods based on pixel classification are powerful but often slow. We introduce two general algorithms, based on sparse classification, for optimizing the computation while still obtaining accurate segmentations. The computational costs of the algorithms are derived, and they are demonstrated on real 3-D m... | 18,815,104 |
Toward realistic and practical ideal observer (IO) estimation for the optimization of medical imaging systems. | The ideal observer (IO) employs complete knowledge of the available data statistics and sets an upper limit on observer performance on a binary classification task. However, the IO test statistic cannot be calculated analytically, except for cases where object statistics are extremely simple. Kupinski have developed a ... | 18,815,105 |
Genetic variation revealed in the chloroplast-encoded RNA polymerase beta' subunit of downy mildew-resistant genotype of opium poppy. | Two accessions of opium poppy, Pps-1 (dark green leaves, highly resistant to downy mildew [DM]) and H-9 (yellowish green leaves, susceptible to DM), which originated from common progenitor SPS49 were selected, and their F(1) and F(2) progenies showed that leaf color trait was governed by single recessive nuclear gene, ... | 18,815,118 |
Modulation of genotoxicity and cytotoxicity by radish grown in metal-contaminated soils. | Members of the Brassicaceae family are known for their anticarcinogenic and genetic material protective effects. However, many of the species of this family accumulate high amounts of metals, which is an undesirable feature. Radish (Raphanus sativus L.) has shown to accumulate metals in roots to a higher extent than ot... | 18,815,122 |
Temporal perturbation of tyrosine phosphoproteome dynamics reveals the system-wide regulatory networks. | Signal transduction systems are known to widely regulate complex biological events such as cell proliferation and differentiation. Because phosphotyrosine-dependent networks play a key role in transmitting signals, a comprehensive and fine description of their dynamic behavior can lead us to systematically analyze the ... | 18,815,124 |
Regulation dynamics of WGD genes during yeast metabolic oscillation. | Saccharomyces cerevisiae and its close relatives are characterized by their propensity to ferment even in the presence of oxygen. It was hypothesized that whole-genome duplication (WGD) led to the development of this efficient fermentative lifestyle (WGD-fermentation hypothesis, Piskur 2001. In this study, we found tha... | 18,815,125 |
Role of the HIV gp120 conserved domain 1 in processing and viral entry. | The importance of the N-terminal region of HIV gp120 conserved domain 1 (gp120-C1) to envelope function has been examined by alanine-scanning mutagenesis and subsequent characterization of the mutagenic effects on viral entry; envelope expression, processing, and incorporation; and gp120 association with gp41. With res... | 18,815,131 |
Acute exercise protects against doxorubicin cardiotoxicity. | Numerous methods have been used to minimize the cardiotoxic effects of the chemotherapeutic agent doxorubicin (DOX), and most have had limited success. Chronic endurance exercise has been shown to protect against DOX cardiotoxicity, but little is known regarding the effects of acute exercise on DOX-induced cardiac dysf... | 18,815,146 |
Is prompt exploratory laparotomy the best attitude for mesenteric ischemia after cardiac surgery? | Mesenteric ischemia following cardiac surgery is a life-threatening complication. Early identification of patients may help optimizing management and improving outcome. Between January 2000 and July 2007, surgical exploration was realized when mesenteric ischemia was suspected after coronary-artery bypass grafts (CABG)... | 18,815,161 |
Aggressive organ donor management protocol. | As of August 2007, 96 900 people are awaiting organ transplantation in the United States, while only 28 930 transplants were performed in 2006. With such a large gap between organ need and organ availability, it is inevitable that many will die while awaiting transplantation. This organ shortage has become a national p... | 18,815,202 |
Inhibitors of GlyT1 affect glycine transport via discrete binding sites. | In the forebrain, synaptic glycine concentrations are regulated through the glycine transporter GlyT1. Because glycine is a coagonist of the N-methyl-D-aspartate (NMDA) receptor (NMDAR), which has been implicated in schizophrenia, inhibition of GlyT1 is thought to provide an option for the treatment of schizophrenia. I... | 18,815,213 |
The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels. | Activator of G protein Signaling 1 (AGS1) and Ras homologue enriched in striatum (Rhes) define a new group of Ras-like monomeric G proteins whose signaling properties and physiological roles are just beginning to be understood. Previous results suggest that AGS1 and Rhes exhibit distinct preferences for heterotrimeric ... | 18,815,223 |
Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(+) T-cell responses which can be defined to the epitope level. | We measured CD8(+) T-cell responses in 12 potentially exposed but uninfected men who have sex with men by using cytokine flow cytometry. Four of the individuals screened exhibited polyfunctional immune responses to human immunodeficiency virus type 1 Gag or Vif. The minimum cytotoxic T lymphocyte epitope was mapped in ... | 18,815,234 |
Effects of medial meniscus posterior horn avulsion and repair on tibiofemoral contact area and peak contact pressure with clinical implications. | Avulsion of the posterior horn attachment of the medial meniscus can compromise load-bearing ability, produce meniscus extrusion, and result in tibiofemoral joint-space narrowing, articular cartilage damage, and osteoarthritis. Avulsion of the posterior horn of the medial meniscus will increase peak contact pressure an... | 18,815,238 |
Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes. | Vesicular glutamate release from astrocytes depends on mobilization of free Ca(2+) from the endoplasmic reticulum (ER), and extracellular space to elevate cytosolic Ca(2+) (Ca(2+)(cyt)). Although mitochondria in neurons, and other secretory cells, have been shown to sequester free Ca(2+) and have been implicated in the... | 18,815,254 |
Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker? | Animal data indicate that methamphetamine can damage striatal dopamine terminals. Efforts to document dopamine neuron damage in living brain of methamphetamine users have focused on the binding of [(11)C]dihydrotetrabenazine (DTBZ), a vesicular monoamine transporter (VMAT2) positron emission tomography (PET) radioligan... | 18,815,269 |
Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo. | Expression of latent membrane protein 2 (LMP2A) during B-cell development leads to global alterations in gene transcription similar to those seen in Hodgkin Reed-Sternberg cells of Hodgkin lymphoma (HL). Along with the consistent detection of LMP2A in Epstein-Barr virus-associated HL, this implicates a role for LMP2A i... | 18,815,281 |
Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma. | Enteropathy-associated T-cell lymphoma, an often fatal complication of celiac disease, can result from expansion of aberrant intraepithelial lymphocytes in refractory celiac disease type II (RCD II). Aberrant intraepithelial lymphocytes and lymphoma cells are intracellularly CD3epsilon(+) but lack expression of the T-c... | 18,815,285 |
Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus. | The genomic viral RNA (vRNA) segments of influenza A virus contain specific packaging signals at their termini that overlap the coding regions. To further characterize cis-acting signals in segment 7, we introduced synonymous mutations into the terminal coding regions. Mutation of codons that are normally highly conser... | 18,815,307 |
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis. | Intratumoral innate immunity can play a significant role in blocking the effective therapeutic spread of a number of oncolytic viruses (OVs). Histone deacetylase inhibitors (HDIs) are known to influence epigenetic modifications of chromatin and can blunt the cellular antiviral response. We reasoned that pretreatment of... | 18,815,361 |
cAMP/PKA signaling and RIM1alpha mediate presynaptic LTP in the lateral amygdala. | NMDA receptor-dependent long-term potentiation (LTP) of glutamatergic synaptic transmission in sensory pathways from auditory thalamus or cortex to the lateral amygdala (LA) underlies the acquisition of auditory fear conditioning. Whereas the mechanisms of postsynaptic LTP at thalamo-LA synapses are well understood, mu... | 18,815,362 |
Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock. | Mammalian circadian clocks consist of regulatory loops mediated by Clock/Bmal1-binding elements, DBP/E4BP4 binding elements, and RevErbA/ROR binding elements. As a step toward system-level understanding of the dynamic transcriptional regulation of the oscillator, we constructed and used a mammalian promoter/enhancer da... | 18,815,372 |
Opposing functions of IKKbeta during acute and chronic intestinal inflammation. | NF-kappaB is a key transcriptional regulator of inflammatory responses, but also controls expression of prosurvival genes, whose products protect tissues from damage and may thus act indirectly in an antiinflammatory fashion. The variable importance of these two distinct NF-kappaB-controlled responses impacts the poten... | 18,815,378 |
Cicatrising conjunctivitis with anti-basement membrane autoantibodies in ectodermal dysplasia. | To report circulating and mucosa-deposited anti-basement membrane zone autoantibodies in a series of six ectodermal dysplasia patients with severe bilateral cicatrising conjunctivitis and blindness due to both corneal disease and intractable surface inflammation. We also report clinical improvement with steroid-sparing... | 18,815,422 |
The elasticity and rigidity of the outer coats of the eye. | The aim of this study was to measure the elastic moduli of the cornea and sclera and the rigidity of the eyeball. Elastic moduli of the cornea and sclera were measured on 22 fresh intact porcine eyes using the relationship between elasticity and changes in pressure and volume applicable to pressure vessel models. Rigid... | 18,815,423 |
Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa. | Mutations in MERTK, a member of the MER/AXL/TYRO3 receptor kinase family, have been associated with disruption of the Retinal Pigment Epithelium (RPE) phagocytosis pathway and settling of autosomal recessive RP (arRP) in humans. This study reports a novel MERTK mutation (IVS16+1G>T) in a Spanish consanguineous famil... | 18,815,424 |
Do attention deficits influence IQ assessment in children and adolescents with ADHD? | To characterize the relationship between IQ and attention deficits in children with ADHD and to estimate the inattention-related mean influence on IQ when children are tested before stimulant drug treatment has been initiated. Studies of various methodologies are reviewed. Correlation studies show mostly weak associati... | 18,815,437 |
"I'm a different kind of nurse": advice from nurses in rural and remote Canada. | The sustainability of the rural and remote nursing workforce in Canada is increasingly at issue as the country becomes more urbanized and the nursing workforce ages. In order to support the retention of nurses in rural and remote communities and the recruitment of nurses to these communities, we require a better unders... | 18,815,470 |
Sleep in the intensive care unit setting. | Sleep is essential to human life. Sleep patterns are significantly disrupted in patients who are hospitalized, particularly those in the intensive care unit. Sleep deprivation is pervasive in this patient population and impacts health and recovery from illness. Immune system dysfunction, impaired wound healing, and cha... | 18,815,477 |
Muscle fascicle and tendon behavior during human locomotion revisited. | High-speed ultrasonography has revealed that, in human locomotion, the nature of fascicle and tendon length changes varies depending on the task, contraction intensity, and the muscles involved. The findings emphasize that the active fascicles of the gastrocnemius muscle are suddenly stretched, although they are shorte... | 18,815,488 |
Hispanics and health insurance coverage: the rising disparity. | Many reports have focused attention on the rising percentage of adults in the United States without health insurance. This hides the fact that the uninsured rate for non-Hispanic nonelderly adults has held fairly steady since 1983, while the rate for Hispanics has increased. To document the trends in the coverage rate ... | 18,815,531 |
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice. | To further explore the oncogenic activity of Aurora A kinase while attempting to develop a useful mouse model for pancreatic cancer, Aurora A kinase was targeted to pancreatic duodenal homeobox gene-1 (Pdx-1)-positive cells. Aurora A kinase overexpression was targeted to mouse pancreas tissues using the Pdx-1 promoter ... | 18,815,537 |
Prophylactic octreotide administration does not prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis of randomized controlled trials. | There is no consensus whether octreotide can prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. We performed a meta-analysis comparing octreotide with placebo in randomized controlled trials. : Electronic databases, including MEDLINE, EMBASE, Cochrane controlled trials register, the Cochra... | 18,815,543 |
Islet auto transplantation following total pancreatectomy: a long-term assessment of graft function. | Total pancreatectomy is considered the final resort in the treatment of chronic pancreatitis; however, here we show that simultaneous islet autotransplantation can abrogate the onset of diabetes. : In Leicester, 46 patients have now undergone total pancreatectomy with immediate islet auto transplant, and they have rece... | 18,815,550 |
Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. | In the present study, a novel pathway by which palmitate potentiates glucose-induced insulin secretion by pancreatic beta cells was investigated. Groups of freshly isolated islets were incubated in 10 mM glucose with palmitate, LY294002, wortmannin, and fumonisin B1 for measurement of insulin secretion by radioimmunoas... | 18,815,554 |
Are acute effects of maximal dynamic contractions on upper-body ballistic performance load specific? | This study investigated the acute effects of upper-body maximal dynamic contractions on maximal throwing speed with 0.55- and 4-kg medicine balls. It was hypothesized that heavy preloading would transiently improve throwing performance only when overcoming the heavier of the two loads. Twenty-three male volunteers were... | 18,815,568 |
Promoter-driven splicing regulation in fission yeast. | The meiotic cell cycle is modified from the mitotic cell cycle by having a pre-meiotic S phase that leads to high levels of recombination, two rounds of nuclear division with no intervening DNA synthesis and a reductional pattern of chromosome segregation. Rem1 is a cyclin that is only expressed during meiosis in the f... | 18,815,595 |
ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis. | DNA methylation is an important epigenetic mark for transcriptional gene silencing (TGS) in diverse organisms. Recent studies suggest that the methylation status of a number of genes is dynamically regulated by methylation and demethylation. In Arabidopsis, active DNA demethylation is mediated by the ROS1 (repressor of... | 18,815,596 |
Future practice of graduates of the New Zealand Diploma of Obstetrics and Gynaecology or Certificate in Women's Health. | To determine: why Diploma of Obstetrics (DipObs), Diploma of Obstetrics and Medical Gynaecology (DipOMG), or Certificate in Women's Health graduates enrolled; course usefulness; and subsequent practice. 588 University of Otago DipObs, DipOMG, and Certificate in Women's Health graduates (1992-2006) plus Auckland Univers... | 18,815,601 |
What can the history tell us? An argument for observed history-taking in the trainee intern long case assessment. | History-taking is one of the most important clinical skills for the medical student to learn and remains the core component of a doctor's diagnostic 'toolkit'. Yet, it is one of the most difficult clinical skills to assess. Clinical assessment at a trainee intern level has typically focussed on examination skills, and ... | 18,815,604 |
Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation. | PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making PKCtheta an attractive therapeutic target for immune modulation. Collagen is a major agonist for platelets, ... | 18,815,612 |
In situ observation of modulated light emission of fiber fuse synchronized with void train over hetero-core splice point. | Fiber fuse is a process of optical fiber destruction under the action of laser radiation, found 20 years ago. Once initiated, opical discharge runs along the fiber core region to the light source and leaves periodic voids whose shape looks like a bullet pointing the direction of laser beam. The relation between damage ... | 18,815,621 |
The sensitivity to key data imputations of recent estimates of income poverty and inequality in South Africa. | Existing literature using South African censuses reports an increase in both poverty and inequality over the 1996 to 2001 period. This paper assesses the robustness of these results to a number of weaknesses in the personal income variable. We use a sequential regression multiple imputation approach to impute missing v... | 18,815,626 |
Ten-year follow-up of a province-wide cohort of surgical lung cancer patients in Nova Scotia. | After a diagnosis of lung carcinoma, survival is poor for all patients. We sought to assess 10-year survival and predictors of outcome after surgery for lung cancer in Nova Scotia. We identified all patients n = 130) undergoing resection for lung cancer in Nova Scotia in 1994 from the Nova Scotia Cancer Registry and ho... | 18,815,647 |
Endoscopic plantar fasciotomy in the treatment of chronic heel pain. | To evaluate endoscopic plantar fasciotomy for the treatment of recalcitrant heel pain. We undertook a retrospective study of the use of endoscopic plantar fasciotomy in the treatment of chronic heel pain that was unresponsive to conservative treatment. Over a 10-year period, we reviewed the charts of 55 patients with a... | 18,815,651 |
Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand. | Two new bis(benzimidazole)aryl derivatives have been prepared and one of them has been shown to induce and stabilize formation of a G-quadruplex. | 18,815,684 |
Apoferritin protein cages: a novel drug nanocarrier for photodynamic therapy. | A methylene blue-encapsulated apoferritin complex shows cytotoxic effects on MCF-7 human breast adenocarcinoma cells when irradiated at the appropriate wavelength. | 18,815,689 |
Direct observation of time and temperature dependent transition from spherical micelles to vesicles. | An interesting transition from spherical micelles to vesicles, which was time and temperature dependent, was observed for the first time; it is tentatively attributed to the thermal hysteresis of temperature-responsive poly(N-isopropylacrylamide). | 18,815,696 |
Sulfate anion-templated assembly of a [2]catenane. | The sulfate anion's templating role in catenane formation is demonstrated for the first time; a novel bis-pyridinium nicotinamide [2]catenane is prepared in a remarkable high yield and is shown to exhibit selectivity for sulfate, the templating anion. | 18,815,700 |
Impact of retirement on risky driving behavior and attitudes towards road safety among a large cohort of French drivers (the GAZEL cohort). | This study investigated changes in driving behavior and attitudes towards road safety, following retirement, in a large cohort of road users. In 2001, 14 226 participants of the GAZEL cohort in France reported their attitudes towards road safety and driving behavior using a self-administered driving behavior and road s... | 18,815,717 |
Meteorological conditions and the diagnosis of occupationally related contact sensitizations. | An accurate diagnosis of (occupational) contact sensitization by patch testing is a prerequisite for efficient preventive management. However, previously observed seasonal fluctuations in patch-test reactions indicate some influence of meteorological conditions. The present analysis aims at quantifying the possible imp... | 18,815,718 |
Body composition obtained from the body mass index: an Italian study. | Since obesity and related diseases are now considered epidemic, new and more accurate formulas for epidemiological studies are of interest to the scientific community. Several equations have been proposed to estimate the body composition simply from anthropometric measurements. However, with time, the body composition ... | 18,815,722 |
Rhodamine-loaded poly(lactic-co-glycolic acid) nanoparticles for investigation of in vitro interactions with breast cancer cells. | Nanoparticle-based drug delivery systems are considered promising for the delivery of imaging agents and drugs for the detection and treatment of illnesses, including cancer. Investigation of nanoparticle interactions with the diseased cells can lead to better designs. In this work, poly(lactic-co-glycolic acid) nanopa... | 18,815,729 |
Phytoestrogens and breast cancer: a complex story. | Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive ... | 18,815,740 |
Tracheal compliance and limit flow rate changes in a murine model of asthma. | Trachea is the unique passage for air to flow in and out. Its tone is of importance for the respiration system. However, investigation on how tracheal tone changes due to asthma is limited. Aiming at studying how the mechanical property changes due to asthma as well as the compliance and flow limitation, the following ... | 18,815,756 |
Antibacterial, antifungal and cytotoxic activity of terrestrial cyanobacterial strains from Serbia. | Cyanobacteria are known to be a rich source of biologically active compounds some of which can have pharmaceutical importance. In this work we present the screening results of cyanobacterial strains for their antibacterial, antifungal, and cytotoxic activity. Cyanobacterial strains were isolated from various soil types... | 18,815,758 |
Positive effects of nicotine on cognition: the deployment of attention for prospective memory. | Human and animal studies over the last two decades report that nicotine can improve cognitive performance. Prospective memory (PM), the retrieval and implementation of a previously encoded intention, is also improved by pre-administration of nicotine. As with other nicotine effects, however, predicting precisely how an... | 18,815,772 |
Tumour and tumour-like lesions of the patella--a multicentre experience. | Fifty-nine cases of lesions presenting in the patella were identified after review of the databases of four European bone tumour registries. Of the 59 cases, 46% were non neoplastic, 39% were benign and 15% were malignant. The commonest benign neoplasm was giant cell tumour (GCT) (11 cases). Younger patients were more ... | 18,815,789 |
Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis. | Src family kinases (SFKs) are signaling enzymes that have long been recognized to regulate critical cellular processes such as proliferation, survival, migration, and metastasis. Recently, considerable work has elucidated mechanisms by which SFKs regulate normal and pathologic processes in vascular biology, including e... | 18,815,812 |
Enhanced removal of dimethyl sulfide from a synthetic waste gas stream using a bioreactor inoculated with Microbacterium sp. NTUT26 and Pseudomonas putida. | The removal of dimethyl sulfide (DMS) from industrial gas streams has received a high priority due to its very low odorous threshold value and relatively low biodegradability compared to other reduced sulfur compounds. A variety of bacteria that utilize DMS as a carbon/energy source have been studied and the degradatio... | 18,815,822 |
Biodegradation of chlorpyrifos in soil by enriched cultures. | Three aerobic bacterial consortia, AC, BC, and DC, developed from pesticide-contaminated soils of Punjab were able to degrade chlorpyrifos after 21 days of incubation in basal medium by 54, 46, and 61% and chlorpyrifos (50 mg/L) in soil after 30 days by 50, 56, and 64%. Pseudomonas aeruginosa, Bacillus cereus, Klebsiel... | 18,815,830 |
Ergonomic risk associated with assisting in minimally invasive surgery. | Given the physical risks associated with performing laparoscopic surgery, ergonomics to date has focused on the primary minimally invasive surgeon. Similar studies have not extended to other operating room staff. Simulation of the assistant's role as camera holder and retractor during a Nissen fundoplication allowed in... | 18,815,838 |
Exudation of alcohol and aldehyde sugars from roots of defoliated Lolium perenne L. grown under sterile conditions. | Root exudates were collected over a 27 day period from defoliated and non-defoliated Lolium perenne L. plants grown under sterile conditions in microlysimeters. Eleven individual sugars, including both aldehyde and alcohol sugars, were identified and quantified with a gas chromatograph-mass spectrometer (GC-MS). There ... | 18,815,840 |
Lymphovascular invasion and lobular histology are associated with increased incidence of isolated tumor cells in sentinel lymph nodes from early-stage breast cancer patients. | Isolated tumor cells (ITC) are more likely to be identified when serial sectioning and immunohistochemical staining are used to evaluate sentinel lymph nodes (SLN). Our goal was to identify clinicopathologic features associated with ITC in patients undergoing sentinel lymph node dissection (SLND). We reviewed clinicopa... | 18,815,841 |
Rapid genotyping of tumor necrosis factor alpha with fluorogenic hybridization probes on the LightCycler. | Genotyping of tumor necrosis factor alpha (TNF-alpha) has become an important procedure in the selection of high-risk population of septic shock and prevention from death due to septic shock. We present a single-tube method for TNF-alpha genotyping that performed on the LightCycler by melting curve analysis with allele... | 18,815,866 |
Successful cryoablation in the noncoronary aortic cusp for a left anteroseptal accessory pathway. | Catheter ablation of anteroseptal accessory pathways may be difficult because of the neighboring conduction tissue that may be damaged with ablation. We report a case of an accessory pathway localized to the anteroseptal region. A pathway potential found in the noncoronary cusp of the aortic valve was successfully targ... | 18,815,874 |
Perceived control and psychological distress in women with breast cancer: a longitudinal study. | The relationship between perceived control and psychological distress in cancer patients has been widely studied, but longitudinal designs are scarce. The aim of this study was to examine whether perceived control could predict changes in the evolution of psychological distress in breast cancer patients at stages I or ... | 18,815,877 |
Application of a numerical simulation to improve the separation efficiency of a sperm sorter. | This paper describes a study in which numerical simulations were applied to improve the separation efficiency of a microfluidic-based sperm sorter. Initially, the motion of 31 sperm were modeled as a sinusoidal wave. The modeled sperm were expected to move while vibrating in the fluid within the microchannel. In this a... | 18,815,887 |
Genetic epidemiology of bladder cancer: scaling up in the identification of low-penetrance genetic markers of bladder cancer risk and progression. | Bladder cancer is an increasingly important international public health problem. As a multifactorial disease, both environmental and genetic factors are involved in its development and progression. This neoplasm is a paradigm for the participation of low-penetrance genetic variants (GSTM1-null and NAT2-slow) and provid... | 18,815,927 |
Avoidance motivation in psychological problems and psychotherapy. | Avoidance of aversive experiences is common to all human beings. However, when avoidance is too strong, it might be associated with impaired psychological functioning and psychopathology. This article examines the role of avoidance motivation in psychological problems and psychotherapy from conceptual, assessment, and ... | 18,815,972 |
Patients' experiences of self-disclosure in psychotherapy: the effects of gender and gender role identification. | This study examined the effects of gender and gender role identification on 223 patients' experiences of self-disclosure in psychotherapy. Factor analysis of the Disclosure-to-Therapist Inventory-IV revealed two dimensions: a distress factor, reflecting the perceived difficulty and the anticipated impact of disclosures... | 18,815,982 |
Randomized control trial of an integrated therapy for comorbid anger and gambling. | This study evaluated an integrated treatment for comorbid problem gambling, anger, and substance use. Problem gamblers with comorbid anger problems (N=42), half of whom also had substance use disorders, were randomized to either a 14-week integrated treatment targeting anger and addictions (i.e., both gambling and subs... | 18,815,997 |
Patients' outcome expectancies and their impression of suitability as predictors of treatment outcome. | In treatment studies, the correlation of patients' outcome expectancies and their impression of treatment suitability with treatment outcome shows a contradictory pattern. It seems that a significant correlation can be shown only if outcome is measured with posttherapy scores or with retrospective success ratings but n... | 18,815,999 |
Electronic structure study of thermal intraconversions of some dicyclopenta-fused polycyclic aromatic compounds. | The electronic structure of dicyclopenta[de,mn]anthracene (P1), dicyclopenta[ de,kl]anthracene (P2), and dicyclopenta[jk,mn]phenanthrene (P3) and their mutual isomerization processes are investigated using density functional theory. Two mechanisms for the thermal intraconversion of P1 to P2 were found. The first mechan... | 18,816,023 |
A computational study on some viable targets for gas-phase synthesis of metal complexes of the cyclic (B6C)-2 and their bonding pattern. | In this account, a detailed computational study is conducted to verify the geometric, energetic, and electronic properties of the planar cyclic (B 6C) (-2) (as the simplest carrier of hexacoordinate carbon) within some metal complexes. The [M(B 6C)] ((-)) (M = Li, Na, K) and [M(B 6C)] (M = Be, Mg, Ca) series are employ... | 18,816,031 |
Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans]. | Herein, the synthesis and pharmacological evaluation of thiophene bioisosteres of the highly potent spirocyclic benzopyran 1 are detailed. The synthesis of 1-benzyl-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3.2- c]pyran] (2a) was performed starting with 3-bromothiophene (3). After introduction of the acetald... | 18,816,044 |
Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors. | On the basis of previous pharmacophore modeling studies of naphthoquinones derivatives, we have designed and synthesized a new set of pyranonaphthoquinones. These compounds were obtained through a direct and highly efficient approach based on an intramolecular domino Knoevenagel hetero Diels-Alder reaction from lawsone... | 18,816,045 |
Fully automated molecular mechanics based induced fit protein-ligand docking method. | We describe a method for docking a ligand into a protein receptor while allowing flexibility of the protein binding site. The method employs a multistep procedure that begins with the generation of protein and ligand conformations. An initial placement of the ligand is then performed by computing binding site hotspots.... | 18,816,046 |
Structural and thermodynamic characterization of T4 lysozyme mutants and the contribution of internal cavities to pressure denaturation. | Using small-angle X-ray scattering (SAXS) and tryptophan fluorescence spectroscopy, we have identified multiple compact denatured states of a series of T4 lysozyme mutants that are stabilized by high pressures. Recent studies imply that the mechanism of pressure denaturation is the penetration of water into the protein... | 18,816,066 |
Cell adhesion to nanoligands: effects of ligand size and concentration in solution. | Cells interact with both tethered and motile ligands in their extracellular environment to initiate and regulate signaling, adhesion, and migration. A quantitative and fundamental understanding of these receptor-ligand interactions is necessary for drug discovery, tissue engineering, and biomaterial fabrication. In thi... | 18,816,080 |
Shotgun proteomics of the haloarchaeon Haloferax volcanii. | Haloferax volcanii, an extreme halophile originally isolated from the Dead Sea, is used worldwide as a model organism for furthering our understanding of archaeal cell physiology. In this study, a combination of approaches was used to identify a total of 1296 proteins, representing 32% of the theoretical proteome of th... | 18,816,081 |
Fluorescence resonance energy transfer in polydiacetylene liposomes. | Conjugated polydiacetylene (PDA) possessing stimuli-responsive properties has been intensively investigated for developing efficient sensors. We report here fluorescence resonance energy transfer (FRET) in liposomes synthesized using different molar ratios of dansyl-tagged diacetylene and diacetylene-carboxylic acid mo... | 18,816,092 |
Immobilization of growth factors on collagen scaffolds mediated by polyanionic collagen mimetic peptides and its effect on endothelial cell morphogenesis. | Angiogenesis, a morphogenic event endothelial cells (ECs) undergo in response to 3-D environmental triggers, is critical to the survival and ultimate functional capacity of engineered tissue constructs. Here we present a new collagen mimetic peptide (CMP) architecture consisting of multiple anionic charges at the pepti... | 18,816,098 |
Carboxymethyl chitosan as a matrix material for platinum, gold, and silver nanoparticles. | Carboxymethyl chitosan (CMC) was evaluated for its use in the synthesis and stabilization of catalytic nanoparticles for the first time. Many studies have reported on the ability of chitosan to bind with metal ions and support metal nanoparticles. CMC has a higher reported chelation capacity than chitosan, which has po... | 18,816,099 |
Organocatalytic asymmetric transferhydrogenation of beta-nitroacrylates: accessing beta2-amino acids. | We describe a highly efficient and enantioselective Hantzsch ester mediated conjugate reduction of beta-nitroacrylates that is catalyzed by a Jacobsen thiourea catalyst as a key step in a new route to optically active beta2-amino acids. | 18,816,115 |
Extraordinary circularly polarized luminescence activity exhibited by cesium tetrakis(3-heptafluoro-butylryl-(+)-camphorato) Eu(III) complexes in EtOH and CHCl3 solutions. | The largest CPL activity ever measured was observed for cesium tetrakis(3-heptafluoro-butylryl-(+)-camphorato) Eu(III) complexes in EtOH and CHCl3 solutions substantiating the stereospecific formation of chiral Delta-SAPR-(C4) configuration with the aid of Cs+...FC (fluorocarbon) interactions more clearly than the exci... | 18,816,117 |
High temperature metalation of functionalized aromatics and heteroaromatics using (tmp)2Zn x 2 MgCl2 x 2 LiCl and microwave irradiation. | A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF via direct zincation using (tmp)2Zn x 2 MgCl2 x 2 LiCl and microwave irradiation. Ester and cyano functions as well as ketones are compatible with the high temperatures of the zincation. The resulting bis-organo zinc speci... | 18,816,136 |
Self-assembly of quantum dots and carbon nanotubes for ultrasensitive DNA and antigen detection. | A highly selective, ultrasensitive, fluorescence detection method for DNA and antigen based on self-assembly of multiwalled carbon nanotubes (CNTs) and CdSe quantum dots (QDs) via oligonucleotide hybridization is reported. Mercaptoalkyloligonucleotide molecules bind to the quantum dots, while amineoalkyloligonucleotide... | 18,816,142 |
A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis. | The patterning of the Arabidopsis root epidermis depends on a genetic regulatory network that operates both within and between cells. Genetic studies have identified a number of key components of this network, but a clear picture of the functional logic of the network is lacking. Here, we integrate existing genetic and... | 18,816,165 |
Thyroid function and exposure to styrene. | Many natural substances and drugs have long been known to cause goiter or thyroid dysfunction. More recently, several environmental pollutants, such as pesticides and industrial compounds, have been investigated for their thyroid-disrupting activity and related adverse effects on human health. The aim of this study was... | 18,816,178 |
Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms. | Although fine-needle aspiration (FNA) biopsy of thyroid nodules is very sensitive in detecting thyroid malignancy, it remains ambiguous in 20-30% of cases. Current biomarkers for thyroid cancer lack either the sensitivity or specificity to substantially address this clinical problem. The aim of this study was to invest... | 18,816,183 |
Preferences and perceived barriers to treatment for depression during the perinatal period. | Little is understood about why few women during the perinatal period will use depression treatment. In particular, beliefs and barriers related to depression treatment use have not been studied. In this study, African American and white pregnant women (n = 108) who screened > or =10 on the Edinburgh Postnatal Depres... | 18,816,202 |
[Light chain deposition disease. Experience in our environment]. | The Light chain deposition disease (LCDD) is a strange entity characterised by the deposition of only one type of light chain in the renal tubular basement membranes. It can be associated to a plasma cell dyscrasia, however, it can occur in the absence of any detectable hematological disorder and it is called idiopathi... | 18,816,213 |
Comparison of antigenemia assay and semiquantitative polymerase chain reaction test for monitoring active cytomegalovirus infection in allogeneic hematopoietic cell transplant recipients. | We sought to compare the antigenemia assay and in-house semiquantitative polymerase chain reaction to monitor human cytomegalovirus infection after transplant in hematopoietic cell transplant recipients. A pp65 antigen test for polymorphonuclear leukocytes and a semiquantitative polymerase chain reaction for whole bloo... | 18,816,243 |
Comparative study of operative treatment [corrected] of varicose veins according to the Klapp and Smetana method versus Myers method. | Venous abnormalities in lower extremities are among the most frequent disorders that affects general population with significant morbidity and mortality. Usually, the problem consists of a mild form of varicose veins and teleangiectasis. Treatment in this stage of disease is highly recommended since progression can lea... | 18,816,266 |
Rates of bluetongue virus transmission between Culicoides sonorensis and sheep. | Two experiments were undertaken to estimate the transmission rates of bluetongue virus (BTV) serotype 1 between a biting midge vector, Culicoides sonorensis (Wirth & Jones) (Ceratopogonidae), and a natural host, sheep. In an experiment to measure the transmission rate from vector to host (V-->H), six batches of ... | 18,816,271 |
A wrinkle in time: asymmetric valuation of past and future events. | A series of studies shows that people value future events more than equivalent events in the equidistant past. Whether people imagined being compensated or compensating others, they required and offered more compensation for events that would take place in the future than for identical events that had taken place in th... | 18,816,287 |
Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in swiss albino mice. | Antioxidants are one of the key players in tumourigenesis, and several natural and synthetic antioxidants have been shown to have anticancer effects. In the present investigation, the efficacy of mangiferin on the antioxidant status of benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice was assessed. The an... | 18,816,296 |
Grievance: the underlying oedipal configuration. | In this paper the author describes some of the clinical features encountered in patients who seem to 'nurture' a persistent grievance. He gives clinical examples, and discusses the nature of the powerful underlying dynamics. He suggests that contained within the patient's grievance is a set of phantasies that constitut... | 18,816,339 |
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