title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Subcoronary implantation of a stentless valve in patients with aortic aneurysms. | Experience with a new operation for patients with aortic valve disease and aneurysm or dissection of the ascending aorta is described. Twenty-four patients aged 66-87 years were operated on using a subcoronary implantation technique with a stentless aortic valve bioprosthesis and an extension using a vascular tube pros... | 18,812,341 |
Factors influencing survival in patients after bidirectional Glenn shunt. | Clinical characteristics, echocardiographic values, and catheterization data of 45 patients with a functional univentricular heart who had a bidirectional Glenn shunt instituted between November 1994 and October 2006 were retrospectively reviewed. Median age at operation was 20 months (range, 9 months to 19 years). Med... | 18,812,346 |
Verapamil and nitroglycerin improves the patency rate of radial artery grafts. | The best way to prevent spasm of the radial artery is still under investigation. We retrospectively compared the effectiveness of topical verapamil-nitroglycerin with papaverine in preventing graft spasm in 215 patients who underwent isolated conventional coronary artery bypass using a radial artery. Postoperative angi... | 18,812,349 |
Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction. | Small heat shock proteins (sHSP) play an important role in the resistance to anticancer drugs. We examined the expression of the sHSP family, HSP27 and alpha-crystallins, in human retinoblastoma with and without preoperative chemotherapy. Eighteen enucleated eyes from patients with retinoblastoma were used. Six patient... | 18,812,387 |
Serial analysis of mutation spectra (SAMS): a new approach for the determination of mutation spectra of site-specific DNA damage and their sequence dependence. | Many mutations occur as a result of DNA synthesis past the site of DNA damage by DNA damage bypass polymerases. The frequency and types of mutations not only depend on the nature of the damage, but also on the sequence context, as revealed from analysis of mutation spectra of DNA exposed to mutagens. Herein we report a... | 18,812,400 |
Self-efficacy moderates the relation between declines in physical activity and perceived social support in high school girls. | To test whether self-efficacy for overcoming barriers to physical activity has direct, indirect (i.e., mediated), or moderating relations with naturally occurring change in perceived social support and declines in physical activity during high school. Latent growth modeling was used with measures completed in the 8th, ... | 18,812,410 |
The treatment of lupus pernio: results of 116 treatment courses in 54 patients. | Lupus pernio is a disfiguring sarcoidosis skin lesion that is difficult to treat and often causes a major psychosocial impact that may adversely affect the patient's quality of life. We reviewed the treatment outcome of 54 patients with lupus pernio who received 116 individual courses of treatment in our sarcoidosis cl... | 18,812,454 |
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. | Leukemic B lymphocytes of a large group of unrelated chronic lymphocytic leukemia (CLL) patients express an unmutated heavy chain immunoglobulin variable (V) region encoded by IGHV1-69, IGHD3-16, and IGHJ3 with nearly identical heavy and light chain complementarity-determining region 3 sequences. The likelihood that th... | 18,812,466 |
Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity. | We outline a powerful method for the directed evolution of integral membrane proteins in the inner membrane of Escherichia coli. For a mammalian G protein-coupled receptor, we arrived at a sequence with an order-of-magnitude increase in functional expression that still retains the biochemical properties of wild type. T... | 18,812,512 |
A channel connecting the mother cell and forespore during bacterial endospore formation. | At an early stage during Bacillus subtilis endospore development the bacterium divides asymmetrically to produce two daughter cells. The smaller cell (forespore) differentiates into the endospore, while the larger cell (mother cell) becomes a terminally differentiated cell that nurtures the developing forespore. During... | 18,812,514 |
Prehospital termination of resuscitation in cases of refractory out-of-hospital cardiac arrest. | Identifying patients in the out-of-hospital setting who have no realistic hope of surviving an out-of-hospital cardiac arrest could enhance utilization of scarce health care resources. To validate 2 out-of-hospital termination-of-resuscitation rules developed by the Ontario Prehospital Life Support (OPALS) study group,... | 18,812,534 |
Volumetric evaluation of liver metastases after thermal ablation: long-term results following MR-guided laser-induced thermotherapy. | To volumetrically analyze liver metastases and posttherapeutic findings of the thermally ablated area after thermal ablation with magnetic resonance (MR)-guided laser-induced thermotherapy in a long-term evaluation using contrast-enhanced MR imaging. The study was approved by the institutional review board, and informe... | 18,812,558 |
Colorectal tumor vascularity: quantitative assessment with multidetector CT--do tumor perfusion measurements reflect angiogenesis? | To establish the relationships between quantitative perfusion computed tomography (CT) parameters-specifically, primary tumor blood flow, blood volume, transit time, and permeability surface-area product-and immunohistologic markers of angiogenesis in colorectal cancer. After institutional review board approval and inf... | 18,812,560 |
High-throughput analysis of HGF-stimulated cell scattering. | Historically, only relatively low-throughput or expensive methods have been available to measure cell migration. Hepatocyte growth factor (HGF) is a ligand for the tyrosine kinase receptor Met that, in addition to mediating proliferation and survival, increases cell motility and metastasis. The authors have developed a... | 18,812,567 |
High-throughput microsomal stability assay for screening new chemical entities in drug discovery. | In this work, the authors present a novel, robotic, automated protocol for assessing a metabolic stability protocol assembled on a Hamilton platform and a new strategy for pooling samples (cassette analysis). To increase the high throughput of the liquid chromatography (LC) step, fast chromatography and automated liqui... | 18,812,573 |
A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions. | As natural peroxisome proliferator-activated receptor-alpha (PPARalpha) ligands, high levels of fatty acids and glucose could lead to hyperactivation of PPARalpha, like that seen in diabetes. Important diabetes research goals are to uncover new metabolic or signaling pathways involved in hyperglycemic cellular injury a... | 18,812,576 |
A multiattribute model for evaluating the benefit-risk profiles of treatment alternatives. | The assessment of the benefits and risks associated with a medicine's use requires careful consideration of a wealth of information of varying format and quality, ranging from efficacy and safety data derived from randomized clinical trials to statistical results from health outcomes studies to spontaneously reported a... | 18,812,582 |
Drug-binding cavities in long-lived biologics: cause for concern but also potential benefit. | Universally present but overlooked cavities or pockets in long-lived biopharmaceuticals, such as monoclonal antibodies (mAbs), are capable of binding small drugs. Such direct interactions can alter the pharmacokinetics of drugs and potentially affect clinical outcome. The extreme differences in the pharmacokinetic prop... | 18,812,610 |
Comorbidities in a cancer patient: problems in pain management and palliation. | Pain management and palliation face a great challenge with inclusion of the palliation teams from the earliest phases of diagnosis. The presented case report highlights that early inclusion of pain and palliative physicians in patient care demands comprehensive evaluation of the symptoms by the palliative physicians wi... | 18,812,616 |
Management of patients with ICDs at the end of life (EOL): a qualitative study. | Implantable cardioverter defibrillator shocks at the end of life are distressing and warrant consideration of implantable cardioverter defibrillator deactivation discussions. A nationwide survey collected physicians' comments regarding such discussions. Vignettes ascertained respondents' practices regarding implantable... | 18,812,618 |
Thirty four years since the discovery of gastrointestinal melatonin. | After the discovery of melatonin in the pineal gland by Lerner and co-workers in 1958, melatonin was also detected in the retina and the human appendix. Later, melatonin was confirmed immunohistologically in all segments of the gastrointestinal tract (GIT), in the guts of bovine embryos and in the GIT of low vertebrate... | 18,812,627 |
Physiological mediators in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced impairment of gastric mucosal defense and adaptation. Focus on nitric oxide and lipoxins. | Prostaglandins mediate various physiological aspects of mucosal defense and the suppression of prostaglandin synthesis in the stomach is a critical event in terms of the development of mucosal injury after NSAID administration. However, it has become clear that other mediators besides prostaglandins can similarly act t... | 18,812,631 |
Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. | Short chain fatty acids (SCFAs) are the major anions in the large intestine. They are produced by a bacterial fermentation of dietary fiber. SCFAs are known to have a variety of physiological and pathphysiological effects on intestine. However, the mechanisms by which intraluminal SCFAs are sensed are not known. In 200... | 18,812,643 |
A surgical device for radiofrequency ablation of large liver tumors. | Radiofrequency ablation has become an accepted treatment option of patients with primary and metastatic liver tumors. We propose an ablation electrode array consisting of 4-8 blade shaped electrodes arranged in a circular geometry for the treatment of large liver tumors. We developed a 3D code based on the finite diffe... | 18,812,644 |
[Histopathologic and ultrastructural study of extraocular muscles in thyroid associated ophthalmopathy]. | To investigate histopathologic and ultrastructural changes of extraocular muscles (EOM) in thyroid associated ophthalmopathy (TAO). Twelve EOM specimens from 11 patients with TAO were observed. Each of the specimen was stained with HE and observed by light microscope,and then was sectioned with ultrathin method and obs... | 18,812,663 |
[Effect of enalapil on renal interstitial fibrosis in rats with unilateral ureteral obstruction]. | To investigate the effect of enalapril on renal interstitial fibrosis in rats with unilateral ureteral obstruction(UUO). UUO model was induced by ligating the left ureter in rats. Male Sprague-Dawley(SD) rats were randomly divided into a sham-operated group(n=16), a UUO model group(n=24), and an enalapril treated group... | 18,812,665 |
[Design and manufacture of the static 3 dimensional screw-plate system and its matching tools]. | To design and manufacture a new type instrument and its matching tools for the proximal femur. A new type instrument of subtrochanterical fracture-static 3-dimensional screw-plate system(STDSP)was designed and manufactured. The different types of accessory instruments which adapted to STDSP,the aiming guide, and the ac... | 18,812,666 |
Gradual deterioration of brainstem cavernous angioma associated with hemophilia--case report. | A 49-year-old man presented with a brainstem cavernous angioma associated with hemophilia manifesting as gradual progression of neurological deficits over a period of 2 weeks. Computed tomography revealed a hematoma and perifocal edema on the left side of the pons, and T(2)-weighted magnetic resonance imaging revealed ... | 18,812,681 |
Decline of serum HBV DNA and no change apportioned by the same hepatic parenchyma cell volume from hepatic fibrosis stage 1 to stage 4 during the natural history of chronic hepatitis B. | During the initial phase of chronic hepatitis B virus (HBV) infection, serum HBV DNA levels are high. Contrarily, fibrosis, cirrhosis and hepatocellular carcinoma have been found in patients with lower serum HBV DNA levels. The aim of this study is to clarify HBV DNA level dynamics of serum apportioned by the same hepa... | 18,812,696 |
Breast-feeding, self-exam, and exercise practices before and after reduction mammoplasty. | The current indications for reduction mammoplasty include the relief of painful physical symptoms of macromastia. Numerous studies have demonstrated not only improvement in physical symptoms following reduction mammoplasty, but postoperative psychological benefits as well, including increased ability to participate in ... | 18,812,705 |
Which venous system to choose for anastomosis in head and neck reconstructions? | It has been postulated that venous thrombosis in free flap surgery necessitates the use of 2 venous anastomoses into different venous systems. We retrospectively analyzed a single surgeon's 10-year experience (August 1993 to August 2003) in primary free flap reconstruction for malignant tumors of the head and neck. Of ... | 18,812,709 |
Quantification of the osmotic expansion in implants filled with polyethylene glycol. | High reoperation rates continue to agonize the field of breast augmentation surgery. Patient dissatisfaction is a contributing factor for reoperations. This is often attributable to patients' desire to be larger after the augmentation. Polyethylene glycol (PEG) is a potential alternative breast implant filler under inv... | 18,812,723 |
Preliminary single center North American experience with the Berlin Heart pediatric EXCOR device. | For children requiring mechanical circulatory support as a bridge to cardiac transplantation in North America, options previously were limited to extracorporeal membrane oxygenation (ECMO) or centrifugal pump ventricular assist, both of which were suitable for only very short term application and were associated with s... | 18,812,737 |
Use of a pulsatile ventricular assist device (Berlin Heart EXCOR) and an interventional lung assist device (Novalung) in an animal model. | Pulsatile ventricular assist devices (VADs) are used in pediatric patients mainly as a bridge to heart transplantation. If severe respiratory failure occurs, extracorporeal membrane oxygenation (ECMO) is currently the treatment of choice. ECMO has the potential for severe complications. Interventional lung assist (iLA)... | 18,812,741 |
Development of a miniaturized heart-lung machine for neonates with congenital heart defect. | Predominantly, standard adult heart lung machines are used for pediatric cardiac surgery, only with individually downsized components. Downsizing is limited, e.g., by the required gas exchange surface. To diminish complications, we developed a new miniaturized heart lung machine (MiniHLM) for neonates, with significant... | 18,812,743 |
Ocular complications in 2 cases with porphyria. | We aimed to report our observation regarding the long-term follow-up results of 2 cases with similar ophthalmic manifestations of 2 different porphyrias, congenital erythropoietic porphyria (CEP), and porphyria cutanea tarda (PCT). Both patients presented with ocular pain and photophobia in both eyes. The patient with ... | 18,812,782 |
Distraction osteogenesis in the management of severe maxillary hypoplasia in cleft lip and palate patients. | The aim of this study was to systematically review literature reporting on the use of external distraction osteogenesis (DO) and internal DO in the treatment of severe maxillary hypoplasia in cleft and palate patients. Literature research has been performed using the PubMed database of the National Library of Medicine ... | 18,812,842 |
Maxillary growth impairment in cleft lip and palate patients: a simplified approach in the search for a cause. | No true consensus exists regarding the causes of maxillary growth restriction in cleft lip and palate patients. The aim of this study was to evaluate a simplified method to identify the causes of this growth impairment. We analyzed a sample of 82 consecutively treated 5-year-old patients with unilateral complete cleft ... | 18,812,855 |
A simple method of fabricating nasal packing armed with ventilation tube. | Various packing materials have been used for closed reduction of nasal bone fractures or for septorhinoplasty. Most patients experience significant discomfort after the surgery owing to the lack of nasal breathing, and there are many reports concerning the complications related to nasal packing. Although nasal packing ... | 18,812,868 |
An isolated bilateral pure macrostomia in a 2-year-old girl. | Congenital macrostomia is a lateral orofacial cleft between the maxillary and mandibular components of the first branchial arch. Bilateral macrostomia is a rare entity. To date, 17 cases have been reported in the literature, with more than 50% isolated. We present a case of bilateral transverse facial cleft (macrostomi... | 18,812,873 |
Nasal hair matrix cyst mimicking dermoid cyst. | Dermoid cysts are primarily observed in the head and neck region. Nasal dermoids are uncommon. The terms nasal dermoid, nasal epidermoid, and nasal sebaceous cysts are used interchangeably by clinicians. Hair matrix cyst is a variant of epidermal cyst resembling the pattern of pilomatrixoma. Formerly, nasal hair matrix... | 18,812,877 |
Patient-controlled epidural analgesia (PCEA) for postoperative pain control after lumbar spine surgery. | Spine surgery remains one of the most common procedures for patients with a wide variety of spine disorders. Postoperative pain after major spine surgery is moderate to severe. We retrospectively reviewed 245 medical records of adult patients undergoing major spine surgery who received either patient-controlled epidura... | 18,812,889 |
Pedicle subtraction osteotomy. | Pedicle subtraction osteotomy (PSO) is an effective tool for the correction of fixed sagittal plane deformity. However, there is potentially significant perioperative morbidity associated with this technique. We report our perioperative morbidity rate in recently performed PSO cases treated with our present surgical, a... | 18,812,921 |
Vertebral column resection for rigid spinal deformity. | Vertebral column resection (VCR) is a surgical technique that may be applied for correction of moderate to severe spinal deformities, including those with large rigid curves, fixed trunk translation, or asymmetry between the length of the convex and concave column of the deformity. This article reviews the VCR techniqu... | 18,812,922 |
Principles of growth modulation in the treatment of scoliotic deformities. | Intraoperative manipulation to correct scoliotic deformities relies upon spinal instrumentation for stabilization and fusion. However, novel strategies and innovative implant biotechnologies have emerged, applying natural growth and elongation of the immature spine for the treatment of scoliosis in young patients. In t... | 18,812,928 |
Decision making in pediatric spinal deformity. | To review the concepts involved in the decision-making process for management of pediatric patients with spinal deformity. The literature was reviewed in reference to pediatric deformity evaluation and management. Pediatric spinal deformity includes a broad range of disorders with differing causes, natural histories, a... | 18,812,934 |
The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report. | Dysembryoplastic neuroepithelial tumor (DNT) occurs rarely in the cerebellum. We describe a rare case of cerebellar DNT that developed contrast enhancement after long-term observation and discuss the underlying mechanism and clinical relevance of this unusual phenomenon. A 34-year-old woman with known cystic cerebellar... | 18,812,941 |
The role of stereotactic radiosurgery for intracranial hemangioblastomas. | To evaluate the role of stereotactic radiosurgery (SRS) in the management of recurrent or residual intracranial hemangioblastomas, we assessed tumor control, survival, and complications in 32 consecutive patients. We retrospectively reviewed records of 32 consecutive hemangioblastoma patients (74 intracranial tumors) w... | 18,812,955 |
Delayed visual deficits and monocular blindness after endovascular treatment of large and giant paraophthalmic aneurysms. | Paraophthalmic aneurysms may exert mass effect on the optic apparatus. Although surgical clipping and endovascular coiling of these aneurysms can be complicated by immediate postoperative visual deterioration, endovascular coil embolization has the unique risk of visual complications later (>24 h) in the perioperati... | 18,812,958 |
Krit1 modulates beta 1-integrin-mediated endothelial cell proliferation. | Using ribonucleic acid interference on cultured cell lines, we examined the role of Krev interaction trapped 1 (krit1) and integrin cytoplasmic domain-associated protein-1 alpha (icap1alpha) in beta1-integrin-mediated cell proliferation. Upon depletion of either krit1 or icap1alpha in the HeLa cells, umbilical vein end... | 18,812,969 |
Excess gestational weight gain amplifies risks among obese mothers. | In this issue of Epidemiology, Chen et al report that obese mothers who gained the most weight during pregnancy had elevated risk for infant mortality. Other outcomes related to excess maternal weight or weight gain not only cause complications around the time of birth but also confer elevated chronic disease risk for ... | 18,813,018 |
Recent heterosexual partnerships and patterns of condom use: a weighted analysis. | In epidemiologic studies of sexual partnerships, characteristics are often collected in part through detailed questions concerning recent partnerships. These data present challenges for analysis. First, although research interest generally lies in all partnerships in a certain time period, participants may be asked to ... | 18,813,022 |
Ambient air pollution and daily mortality among survivors of myocardial infarction. | Certain subgroups in the general population, such as persons with existing cardiovascular or respiratory disease, may be more likely to experience adverse health effects from air pollution. In this European multicenter study, 25,006 myocardial infarction (MI) survivors in 5 cities were recruited from 1992 to 2002 via r... | 18,813,023 |
Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. | Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood. The authors investigated the fate of inhaled nitric oxide (80 parts per million) in mice and quantified the for... | 18,813,047 |
A rational approach to perioperative fluid management. | Replacement of assumed preoperative deficits, in addition to generous substitution of an unsubstantiated increased insensible perspiration and third space loss, plays an important role in current perioperative fluid regimens. The consequence is a positive fluid balance and weight gain of up to 10 kg, which may be relat... | 18,813,052 |
Recent advances in cultivated epithelial transplantation. | Currently, cultivated epithelial transplantation usually uses ex vivo-expanded epithelial cells, with or without biological carriers. Our group has carried out approximately 100 such procedures and has conducted research in this area. The results of a retrospective study indicate that cultivated limbal epithelial trans... | 18,813,074 |
Effects of the medication nursing assistant role on nurse job satisfaction and stress in long-term care. | Long-term care nurses continue to struggle with increasing workloads, fulfilling regulatory requirements and limited staffing resources. One method of impacting the workload is the introduction of the new medication nursing assistant (MNA) role to alleviate the nurse from prolonged time intervals spent administering me... | 18,813,086 |
Image-guided transsylvian, transinsular approach for insular cavernous angiomas. | Surgical treatment of cavernomas arising in the insula is especially challenging because of the proximity to the internal capsule and lenticulostriate arteries. We present our technique of image guidance for operations on insular cavernomas and assess its clinical usefulness. Between 1997 and 2003, with the guidance of... | 18,813,148 |
Surgical risks associated with the management of Grade I and II brain arteriovenous malformations. | Grade I and II arteriovenous malformations (AVMs) have been considered safe to resect. However, unoperated low-grade AVMs have not been considered in previously reported series. The aim of this study was to examine all cases, both operated and unoperated, to identify any characteristics of low-grade AVMs that comprise ... | 18,813,149 |
Operation of arteriovenous malformations assisted by stereoscopic navigation-controlled display of preoperative magnetic resonance angiography and intraoperative ultrasound angiography. | To study the application of navigated stereoscopic display of preoperative three-dimensional (3-D) magnetic resonance angiography and intraoperative 3-D ultrasound angiography in a clinical setting. Preoperative magnetic resonance angiography and intraoperative ultrasound angiography are presented as stereoscopic image... | 18,813,150 |
Evolution of brain tissue injury after evacuation of acute traumatic subdural hematomas. | Acute traumatic subdural hematoma complicated by brain parenchymal injury is associated with a 60 to 90% mortality rate. Early surgical evacuation of the mass lesion is essential for a favorable outcome, but the severity of the underlying brain injury determines the outcome, even when surgery has been prompt. The purpo... | 18,813,164 |
Surgery of cerebral trauma and associated critical care. | The last 30 years have been both exciting and frustrating for those in the field of traumatic brain injury (TBI). Much has been learned, but no new treatment has been shown to improve patient outcomes despite the execution of many clinical trials. The overall incidence of TBI has decreased, probably because of intensiv... | 18,813,168 |
The combined effect of calcium channel blocker Lercanidipine and antioxidants on low-grade systemic inflammation parameters in essential hypertension patients. | The influence of oxidative stress (OS) and inflammation on up-regulation of blood pressure (BP) has been well established. Peripheral polymorphonuclear leukocytes (PMNLs) are primed in essential hypertension (EH) patients, releasing uncontrolled superoxide anion contributing to OS in these patients. PMNL priming correl... | 18,813,182 |
Optical coherence tomography: clinical applications and the evaluation of DES. | Optical coherencet tomography (OCT) is a light-based imaging modality that can provide in vivo high-resolution images of the coronary artery. In the last years there has been a continuous technical development that has improved the image quality and has simplified the acquisition procedure in order to spread the clinic... | 18,813,186 |
Management of nerve sheath tumors arising in the sympathetic chain. | Extradural schwannomas arising from the sympathetic chain are uncommon benign nerve sheath tumors. We present our experience with three patients having such tumors located in the cervical, thoracic and lumbar regions and we describe clinical presentation, surgical treatment, and outcomes. Between 2002 and 2006, the med... | 18,813,203 |
Treatment strategies to optimize clinical benefit in the patient with myelodysplastic syndromes. | In recent years we have witnessed a transformation in care for patients with myelodysplastic syndromes (MDS) following approval by the US Food and Drug Administration of the first agents for treatment of the disease. Emerging evidence indicates that active treatment strategies modify the natural history of the underlyi... | 18,813,207 |
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. | We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schiz... | 18,813,210 |
Racial differences in chronic kidney disease incidence and progression among individuals with HIV. | This Practice Point commentary discusses the findings of Lucas et al.'s longitudinal cohort study of chronic kidney disease (CKD) in African American and white individuals with HIV. The study found that--compared with whites--African Americans had a slightly increased risk of incident CKD, but markedly increased rates ... | 18,813,233 |
Status of chronic kidney disease prevention programs: International Federation of Kidney Foundation Members 2005/2007. | The International Federation of Kidney Foundations surveyed its members on chronic kidney disease 'prevention' programs in their regions and countries in 2005 and 2007. A profile was developed, representing 28 countries (56% response). Some form of screening activity was reported in 24 of the 28 countries (85.7%). Two ... | 18,813,288 |
Phagosome maturation: going through the acid test. | Phagosome maturation is the process by which internalized particles (such as bacteria and apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound structures, leading to particle degradation. The characterization of the phagosomal proteome and studies in model organisms and mammals have le... | 18,813,294 |
Breast cancer awareness among older women. | The aim of this study was to elicit the level of breast cancer awareness in older women. A cross-sectional study-specific questionnaire survey of 712 British women aged 67-73 years (response rate 83.8%), assessing knowledge of symptoms and risk and confidence to detect a change, was conducted. Over 85% of respondents w... | 18,813,307 |
Facile cyanamide-ammonia coupling mediated by cis- and trans-[PtIIL2] centers and giving metal-bound guanidines. | Diffusion of ammonia into CH(2)Cl(2) solutions of the dialkylcyanamide complexes cis- or trans-[PtCl(2)(RCN)(2)] (R = NMe(2), NEt(2), NC(5)H(10)) at 20-25 degrees C leads to metal-mediated cyanamide-ammonia coupling to furnish, depending on reaction time, one or another type of novel bisguanidine compound, i.e. the mol... | 18,813,372 |
An integrated QCM-based narcotics sensing microsystem. | We present the design, fabrication and successful testing of a 14x14x4 mm3 integrated electronic narcotics sensing system which consists of only four parts. The microsystem absorbs airborne narcotics molecules and performs a liquid assay using an integrated quartz crystal microbalance (QCM). A vertically conductive dou... | 18,813,386 |
[Social inequalities, healthcare and well-being: opportunities and obstacles on the horizon of transversal public policies]. | The development of a distributive justice model that is responsive to new claims and demands in the social policy field requires in-depth examinations and critiques of the ways in which public policies are drawn up and implemented. Reconstituting and analyzing different institutional dynamics, decision contexts and pro... | 18,813,477 |
[Unconditional to conditional rights: counterparts in Brazil's Family Allowance Program]. | This paper analyzes the concepts and challenges of the counterpart contributions demanded by Brazil's Family Allowance Program, which requires mandatory school attendance for children and adolescents, and healthcare for children, pregnant women and breast-feeding mothers. These issues are prompting much discussion in B... | 18,813,483 |
[Healthcare rights and conditional cash transfers in Latin America]. | Conditional cash transfer programs in Latin America impose specific requirements and responsibilities on beneficiary households, in order to upgrade education levels, improve drop-out rates and eliminate child labor, while enhancing health and nutrition indicators. Although counterpart healthcare conditions are common ... | 18,813,487 |
[Private home healthcare and its strategies (apparent and hidden)]. | This paper analyses the findings of an investigation into private home healthcare. Considered the most visible model of Managed Healthcare, it is being developed through the supply of multiple services. This concept is based on a set of principles - out-of-hospital care, lower infection risks, family-based benefits for... | 18,813,501 |
[Sanitary and socio-environmental conditions in the Iauaretê indigenous area, São Gabriel da Cachoeira, Amazonas State, Brazil]. | To describe sanitary, social and environmental conditions that are significant for health of residents in the Iauaretê Indigenous Area in Brazilian Amazonia, notable for its population concentration. Qualitative and quantitative methodologies were used, with the action research method deployed mainly for qualitative ap... | 18,813,507 |
[Evaluation of oral health actions in the Family Health Program in the Mosqueiro district, Pará State, Brazil]. | The extension of Brazil's Family Health Program Teams through the introduction of Oral Health Teams (OHT) as required by Decree N degrees 1,444 dated December 28, 2000, was an important step in the restructuring of the Oral Healthcare System, ensuring easier access to good quality dental care and treatment for less pri... | 18,813,518 |
[Satisfaction with dental care: qualitative study of the mothers of children treated at the Santa Catarina Federal University, Brazil]. | This survey examines perceptions among mothers of the treatment provided through pediatric dentistry clinic at the Santa Catarina Federal University and their concept of the 'ideal' dentist, using the qualitative (case study) method. Collected through semi-structured interviews with seven mothers of children treated at... | 18,813,519 |
[Punishment, penalty or providence? Morbidity due to external causes in basic healthcare, Porto Alegre, Brazil]. | This research project is based on the work of the External Causes Observer Group for Municipal Health Services under the Partenon and Lomba do Pinheiro District Administration in Porto Alegre, Brazil. It reflects on the actions and roles of Health Services in response to injuries due to External Causes, from the standp... | 18,813,526 |
[Ways of inserting physicians into the healthcare production process: case of study of basic healthcare units in Belo Horizonte, Brazil]. | The main purpose of this paper is to describe and analyze the ways of inserting physicians into the health production process. This subject is justified by a belief that that this way of working may be a problem but at the same time may well be the key to implementing healthcare models that are ethically and politicall... | 18,813,530 |
[Self-assessment in graduate public health programs: characteristics and constraints]. | The purpose of this paper is to discuss the characteristics and constraints of internal appraisals or self-assessments in Graduate Public Health Programs, conducted through a study of the report on 25 programs participating in the three-year CAPES evaluation (2001-2003). Three main aspects were considered: (a) tools an... | 18,813,536 |
Research and the (free and) informed consent. | The aim of this article was to reflect about the Free and Informed Consent (IC) in qualitative researches in the health field. Coming from the experience of being part of a CER (Committee for Ethic in Research) in the health area the authoresses place in debate some important questions, exploring them and conducting su... | 18,813,550 |
[Is the principlist model still satisfactory for the analysis of the morality of the scientific research involving human beings?]. | This paper discusses the application of principlism to research involving human subjects, starting from the question of its pertinence in the current situation of the paradigmatic pluralization on science and the multiplication of models of ethical evaluation in the complex societies. Highlights that the development of... | 18,813,552 |
[Research ethics in social sciences--new challenges]. | This paper aims to discuss how already established principles of research ethics can be incorporated to the ethical review of research projects in Social Sciences, particularly ethnographic studies or studies using the techniques of participant observation and open interviews. The discussion is guided by an analysis of... | 18,813,558 |
[The Family Health Program (FHP) and human resources: perceptions of students from two different dentistry schools]. | The purpose of this study was to evaluate the perceptions and opinions of dental students from two different Dentistry Schools in Brazil, both known here as Dentistry Schools 1 and 2 about the Family Health Program--FHP. The study analyzed if the Dentistry Schools had any influence on the students, graduating professio... | 18,813,569 |
[Profile of clinical research subjects in an independent outpatient center]. | This paper assesses the quality of assistance in a clinical trial outpatient center as well as the patients understanding of the informed consent (IC); determine the reasons why they participate and detail socio-economic levels. A cross-sectional study was adopted in a clinical trial outpatient center using a self-expl... | 18,813,596 |
[Representations of aging for community health agents and nursing professionals: psychological aspects of the health-disease process]. | This paper addresses the aging process in the context of public health, with emphasis to human resources and to how aging is perceived by the public health professionals. The aim of this study was to identify the representations of the aging process for public health professionals and how these representations are expr... | 18,813,627 |
[Procedures and perceptions of professionals and groups acting in the Brazilian health plan market]. | This study analyzes the mechanisms used in Brazil by health plan and insurance operators, hospitals and physicians for organizing the access to health care services and their strategies towards cost reduction and decision-making. The study is based on the literature about regulation of the health services, with special... | 18,813,650 |
[Compared supplementary healthcare policies in the context of public health systems: European Union and Brazil]. | This paper analyzes the supplementary healthcare policies adopted in recent years in Brazil and in European countries. The proposed approach is a comparative analysis of the private health plan and insurance policies in the context of the European Union and Brazilian public health systems. This comparison allowed estab... | 18,813,647 |
[Control of carotenoid loss in vegetables prepared in a hospital foodservice]. | The aim of this study was to assess the handling procedures of kale and tomatoes in a hospital foodservice (HFS) in order to control loss of beta-carotene and licopene. The adopted measures, up to then not used by the HFS, were: 24-h storage under refrigeration (10 degrees C), hygienizing for 15 min and distribution im... | 18,813,663 |
[Evaluation of emergency hospital services in the state of Rio de Janeiro]. | This study aimed at the evaluation of urgency/emergency hospital units and recorded the relations of emergency units with users, other hospital services and the healthcare network and approached the size of the teams, the relations among the professionals, their qualification and income. It further describes the infras... | 18,813,664 |
[Definition of priority medicines for monitoring laboratory quality in Brazil: the interface between health surveillance and the National Drug Policy]. | A key objective of the Brazilian National Drug Policy is the quality of medicines supplied to the population. This study aimed to set priorities for the analysis of the National Program for Quality Control of Medicines. The main criterion was the drug's presence in at least three Pharmaceutical Care Programs under the ... | 18,813,684 |
Professor Octávio de Silveira: the pioneer of neurology in the State of Paraná. | The author gives a brief overview of the career of Professor Octávio da Silveira, the first neurologist and professor of neurology in the State of Paraná, as well as the first full professor of clinical neurology in the Federal University of Paraná. | 18,813,730 |
Population dynamics of Aceria guerreronis Keifer (Acari: Eriophyidae) and associated predators on coconut fruits in Northeastern Brazil. | Aceria guerreronis Keifer can cause severe damage to coconuts in several countries around the world. Rare studies have been conducted to determine the predatory mites associated with A. guerreronis in Brazil. The study evaluated the prevalence of A. guerreronis and associated predators on the bracts and on the surface ... | 18,813,749 |
Is alcohol really good for health? | Several observational follow-up studies about cardiovascular health have found an overlap between moderate drinking and lower mortality from coronary heart disease and other causes. However, such studies have serious methodological limitations. Most non-drinkers were in fact ex-drinkers, that is, people who had had to ... | 18,813,769 |
[Efficacy of oxcarbazepine treatment in patients diagnosed with cocaine abuse/dependence]. | To assess the efficacy of oxcarbazepine in the treatment of cocaine addiction and its influence on impulsivity and craving in cocaine addicts. A prospective, observational and clinical study was conducted in patients diagnosed with cocaine abuse/dependence (DSM IV criteria), monitoring supervised treatment with oxcarba... | 18,813,772 |
Regulation of p63 expression in primary and immortalized nasopharyngeal epithelial cells. | Mutation of the p53 gene is a common event in human cancer. Interestingly, p53 mutation is uncommon in nasopharyngeal carcinoma (NPC). The DeltaNp63 has been postulated to have a dominant-negative effect on the function of the p53 gene and may play a role in the pathogenesis of nasopharyngeal carcinoma. Immortalization... | 18,813,784 |
HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome. | Introducing highly active antiretroviral therapy (HAART) has significantly decreased the morbidity and mortality in human immunodeficiency virus-positive (HIV+) individuals by decreasing the viral loads and increasing the CD4+ T-cell counts. Subsequently, the occurrence of many HIV-associated diseases has been dramatic... | 18,813,791 |
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