title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport. | Transport of proteins and lipids between intracellular compartments is fundamental to the organization and function of eukaryotic cells. The efficiency of this process is greatly enhanced through coupling of membranes to microtubules. This serves two functions, organelle positioning and vesicular transport. In this stu... | 18,817,524 |
The ESCRT-I subunit TSG101 controls endosome-to-cytosol release of viral RNA. | Like other enveloped viruses, vesicular stomatitis virus infects cells through endosomes. There, the viral envelope undergoes fusion with endosomal membranes, thereby releasing the nucleocapsid into the cytoplasm and allowing infection to proceed. Previously, we reported that the viral envelope fuses preferentially wit... | 18,817,529 |
The signature of long-standing balancing selection at the human defensin beta-1 promoter. | Defensins, small endogenous peptides with antimicrobial activity, are pivotal components of the innate immune response. A large cluster of defensin genes is located on human chromosome 8p; among them the beta defensin 1 (DEFB1) promoterhas been extensively studied since discovery that specific polymorphisms and haploty... | 18,817,538 |
Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. | The long latent stage seen in syphilis, followed by chronic central nervous system infection and inflammation, can be explained by the persistence of atypical cystic and granular forms of Treponema pallidum. We investigated whether a similar situation may occur in Lyme neuroborreliosis. Atypical forms of Borrelia burgd... | 18,817,547 |
Abbreviation definition identification based on automatic precision estimates. | The rapid growth of biomedical literature presents challenges for automatic text processing, and one of the challenges is abbreviation identification. The presence of unrecognized abbreviations in text hinders indexing algorithms and adversely affects information retrieval and extraction. Automatic abbreviation definit... | 18,817,555 |
An ontology for Xenopus anatomy and development. | The frogs Xenopus laevis and Xenopus (Silurana) tropicalis are model systems that have produced a wealth of genetic, genomic, and developmental information. Xenbase is a model organism database that provides centralized access to this information, including gene function data from high-throughput screens and the scient... | 18,817,563 |
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. | It is well known that most neurodegenerative diseases are associated with microglia-mediated inflammation. Our previous research demonstrates that the CD40 signaling is critically involved in microglia-related immune responses in the brain. For example, it is well known that the activation of the signal transducer and ... | 18,817,573 |
Low wintertime vitamin D levels in a sample of healthy young adults of diverse ancestry living in the Toronto area: associations with vitamin D intake and skin pigmentation. | Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes. Recent research indicates that concentrations of serum 25-hydroxyvitamin D [25(OH)D], the main indicator of vitamin D status, should be in excess of 75 nmol/L. Low levels of 25(OH)D have been associated with several chroni... | 18,817,578 |
A retrospective analysis of human cystic echinococcosis in Hamedan province, an endemic region of Iran. | In a retrospective investigation, the medical files of the patients who, between 1992 and 2006, underwent surgery for the treatment of cystic echinococcosis (CE) in one of the three university hospitals in Hamedan province, in western Iran, were explored. Of the 179 patients involved, 44.1% were male and 55.9% female, ... | 18,817,601 |
Stimulation of Na+-Ca2+ exchange by purified antibody against alpha-2 repeat of Na+-Ca2+ exchanger in rat cardiomyocytes. | The aim of the present study was to investigate the effect of the antibody against alpha-2 repeat on Na+-Ca2+ exchanger (NCX) current (I(Na/Ca)). To evaluate the functional specificity of this antibody, its effects on L-type Ca2+ current (I(Ca,L)), voltage-gated Na+ current (I(Na)) and delayed rectifier K+ current (I(K... | 18,817,621 |
Discrimination analysis of mass spectrometry proteomics for ovarian cancer detection. | A discrimination analysis has been explored for the probabilistic classification of healthy versus ovarian cancer serum samples using proteomics data from mass spectrometry (MS). The method employs data normalization, clustering, and a linear discriminant analysis on surface-enhanced laser desorption ionization (SELDI)... | 18,817,630 |
Ventricular arrhythmia onset during diagnostic coronary angiography with a 5F or 4F universal catheter. | Of 18,365 patients who underwent coronary angiography with a 4F or 5F universal catheter between April 2004 and May 2007, 24 (0.131%) experienced sustained ventricular tachycardia or ventricular fibrillation during the procedure. There was no significant difference in any clinical or angiographic characteristic between... | 18,817,686 |
[Static posturography versus clinical tests in elderly people with vestibular pathology]. | Balance can be quantified by clinical tests and through instrumental studies. The objective of this paper is to determine the correlation between static posturography and 4 clinical tests of balance in elderly people with vestibular disorders and to identify its capability to discriminate the groups studied. 60 patient... | 18,817,715 |
Potential associations between fecal shedding of Salmonella in feedlot cattle treated for apparent respiratory disease and subsequent adverse health outcomes. | A prospective cohort study was used to assess whether Salmonella fecal shedding in commercial feedlot cattle treated with antimicrobials for respiratory disease was associated with subsequent adverse health outcomes. Feces were collected per rectum from cattle that were examined for apparent respiratory disease, had a ... | 18,817,722 |
Multiple roles of calcium ions in the regulation of neurotransmitter release. | The intracellular calcium concentration ([Ca(2+)]) has important roles in the triggering of neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter release is initiated by quite high concentrations within microdomains, while short-term facilitation is strongly influenced by the global bu... | 18,817,727 |
Calcium channel regulation and presynaptic plasticity. | Voltage-gated calcium (Ca(2+)) channels initiate release of neurotransmitters at synapses, and regulation of presynaptic Ca(2+) channels has a powerful influence on synaptic strength. Presynaptic Ca(2+) channels form a large signaling complex, which targets synaptic vesicles to Ca(2+) channels for efficient release and... | 18,817,729 |
3,4-Dihydroxyphenylalanine gel diffusion assay for polyphenol oxidase quantification. | We have developed a simple, inexpensive plate assay to detect and quantify polyphenol oxidase (PPO) activity from different origins. The logarithm of enzyme activity is linearly correlated with the diameter of the dark, l-3,4-dihydroxyphenylalanine (l-DOPA) oxidized circles produced in the gel, thereby allowing quantif... | 18,817,742 |
Control of the blue fluorescent protein with advanced evolutionary pulse shaping. | We demonstrate optical coherent control of the two-photon fluorescence of the blue fluorescent protein (BFP), which is of interest in investigations of protein-protein interactions. In addition to biological relevance, BFP represents an interesting target for coherent control from a chemical perspective due to its many... | 18,817,751 |
The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. | Exposure to toxic polycyclic aromatic hydrocarbons raises a number of toxic and carcinogenic responses in experimental animals and humans mediated for the most part by the aryl hydrocarbon -- or dioxin -- receptor (AHR). The AHR is a ligand-activated transcription factor whose central role in the induction of drug-meta... | 18,817,753 |
Similar behaviour and primate-like properties of adult canine Schwann cells and olfactory ensheathing cells in long-term culture. | Adult canine Schwann cells and olfactory ensheathing cells (OECs) have been shown to promote neural regeneration in vivo. Since the majority of studies have been performed in rodents, it is not yet clear in how far OECs from large animals and humans share the reported properties. Moreover, due to the lack of comparativ... | 18,817,757 |
D-Glucose sensing by a plasma membrane regulator of G signaling protein, AtRGS1. | Plants use sugars as signaling molecules and possess mechanisms to detect and respond to changes in sugar availability, ranging from the level of secondary signaling molecules to altered gene transcription. G-protein-coupled pathways are involved in sugar signaling in plants. The Arabidopsis thaliana regulator of G-pro... | 18,817,773 |
Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats. | The nicotinic partial agonist varenicline (VCL) is a recently approved medication for the treatment of tobacco dependence, yet very little preclinical research on this drug has been published. The present experiment examined the nicotinic partial agonist properties of VCL and its parent compound, cytisine (CYT), in a n... | 18,817,808 |
Fourier transform infrared study of protein secondary structural changes in the muscle of Labeo rohita due to arsenic intoxication. | Protein is one of the most important nutrients in human diets and fish has become an increasingly important source of protein in most of the developing countries. Among the various fish tissues, muscle is the major contributor of proteins and the whole mass of the body. The goal of this study is to assess the changes i... | 18,817,838 |
Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma. | Glaucoma (GL) is an optic neuropathy characterized by progressive loss of visual field due to retinal cell death and optic nerve (ON) degeneration, usually in response to abnormal elevated intraocular pressure (EIOP). It has previously demonstrated that cells of the ON express nerve growth factor (NGF) and NGF-receptor... | 18,817,846 |
Timed restricted feeding restores the rhythms of expression of the clock protein, Period2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in adrenalectomized rats. | Feeding schedules that limit food availability to a set time of day are powerful synchronizers of the rhythms of expression of the circadian clock protein Period 2 (PER2) in the limbic forebrain in rats. Little is known, however, about the mechanisms that mediate the effect of such timed restricted feeding (TRF) schedu... | 18,817,849 |
Bmi1 promotes prostate tumorigenesis via inhibiting p16(INK4A) and p14(ARF) expression. | We report here that the polycomb group protein Bmi1 promotes prostate tumorigenesis. Bmi1 is detected at higher levels in androgen-independent PC3 and DU145 than in androgen-dependent LNCaP prostate cancer (CaP) cells. Ectopic Bmi1 enhanced the expression of human telomerase reverse transcriptase (hTERT) and suppressed... | 18,817,867 |
High-level expression of active recombinant ubiquitin carboxyl-terminal hydrolase of Drosophila melanogaster in Pichia pastoris. | Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin. The high specificity for the recognition site makes UCHs useful enzymes for in vitro cleavage of ubiquitin fusion proteins. In this work, an active C-terminal His-tagged UCH from Drosophila melanogaster (D... | 18,817,875 |
Classical crosses of common carp (Cyprinus carpio L.) show co-segregation of antibody response with major histocompatibility class II B genes. | In cyprinids, two paralogous groups of major histocompatibility (MH) class II B genes, DAB1 and DAB3, have been reported but have not been studied in detail. In our study on MH association with immune responsiveness in common carp (Cyprinus carpio L.) we have taken a long-term approach using divergent selection for ant... | 18,817,879 |
Go no-go performance under psychosocial stress: beneficial effects of implementation intentions. | Acute stress has been found to have negative and implementation intentions (IIs) to have positive effects on cognitive performance. This study was the first to examine the effects of IIs on executive action control under acute psychosocial stress. Forty-two male subjects aged 21-39 years were randomly assigned to the T... | 18,817,886 |
Effectiveness, safety, and acceptability of cryotherapy by midwives for cervical intraepithelial neoplasia in Maharashtra, India. | To evaluate the effectiveness, safety, and acceptability of cryotherapy for cervical intraepithelial neoplasia (CIN) when provided by trained midwives in rural India. Women with colposcopic findings of CIN lesions suitable for ablative treatment received cryotherapy from trained midwives before the biopsy results were ... | 18,817,909 |
Gastric neuroendocrine carcinoma associated with atrophic gastritis in the norwegian lundehund. | In humans and rodents the association between atrophic gastritis, hypergastrinemia and gastric neoplasia is well-documented. Gastric tumours are rare in dogs, but the Norwegian Lundehund (puffin dog) appears predisposed to the development of gastric neoplasia associated with chronic atrophic gastritis. The present stud... | 18,817,920 |
Study of surface electrocardiogram spectrum before and after pulmonary vein ablation in patients with persistent atrial fibrillation. | Atrial fibrillation (AF) is the most common clinical cardiac arrhythmia and is usually treated with the electrical isolation of the pulmonary veins from the atria. However, it is estimated that about 30% of the patients undergoing this therapy will develop AF again. The purpose of this study was to test the dynamic cha... | 18,817,922 |
Biomarkers of environmental toxicity and susceptibility in autism. | Autism spectrum disorders (ASDs) may result from a combination of genetic/biochemical susceptibilities in the form of a reduced ability to excrete mercury and/or increased environmental exposure at key developmental times. Urinary porphyrins and transsulfuration metabolites in participants diagnosed with an ASD were ex... | 18,817,931 |
Bilateral extravesical ureteral reimplantation in toilet-trained children: short-stay procedure without urinary retention. | We have previously reported on the ability of toilet-trained children to undergo bilateral extravesical ureteral reimplantation with a 1-day hospitalization and without urinary retention using a critical pathway and modification of the surgical technique. The objective of this study was to determine whether additional ... | 18,817,956 |
Psychomotor functioning in chronic fatigue syndrome and major depressive disorder: a comparative study. | Studies comparing chronic fatigue syndrome (CFS) and major depressive disorder (MDD) reported similarities as well as differences between the two disorders. However, whereas psychomotor symptoms have been studied extensively in MDD, such research in CFS is more limited. Moreover, the few studies that compared cognitive... | 18,817,977 |
Development and validation of the Combined Emotional and Affective Temperament Scale (CEATS): towards a brief self-rated instrument. | Temperament relates to both emotional dimensions and prevailing mood, but these different views are rarely integrated. Based on a model where temperament works as a system with activation, inhibition and control (inspired in Cloninger's and Rothbart's models), which produce the affective tone (inspired by Akiskal's and... | 18,817,978 |
Sulphurous water inhalations in the prophylaxis of recurrent upper respiratory tract infections. | The aim of this study was to evaluate the efficacy and the effect of sulphurous thermal water inhalations in the treatment of the recurrent upper respiratory tract (RURT) infections in children. A total of 100 children with RURT infections were included. All children underwent a 12-day course warm vapour inhalations. F... | 18,817,987 |
Long-term effects of the antifouling booster biocide Irgarol 1051 on periphyton, plankton and ecosystem function in freshwater pond mesocosms. | Irgarol is a highly effective biocide used in antifouling coatings to prevent the growth of periphyton. Environmental concentrations of Irgarol in marine and freshwater have often exceeded the effect concentrations of autotrophic organisms tested in the laboratory and give reason for concern that natural periphyton com... | 18,817,992 |
Pioglitazone induces regression of coronary atherosclerotic plaques in patients with type 2 diabetes mellitus or impaired glucose tolerance: a randomized prospective study using intravascular ultrasound. | A large clinical trial clarified that pioglitazone reduces cardiovascular events in diabetic patients. However, effects of pioglitazone on structure of coronary atherosclerotic plaques have not been demonstrated. We examined whether pioglitazone reduces volumes of coronary atherosclerotic plaques using intravascular ul... | 18,817,993 |
[A rare splenic lesion, the splenoma or splenic hamartoma]. | We report a new case of splenoma in a previously healthy adult. A 52-year-old man was admitted for a splenomegaly with thrombocytopenia. The computed tomographic scan showed a tumor which measured 56 mm in diameter. A splenectomy was performed. Histologic examination of the splenectomy specimen revealed a splenoma. Spl... | 18,818,001 |
Quality of life in climacteric Chilean women treated with low-dose estrogen. | To evaluate the impact of low-dose oral estrogen therapy on the health-related quality of life (HRQoL) in 45-64-year-old women from the East Metropolitan Health Service (SSMO) in Santiago, Chile. We conducted an observational cross-sectional study. A random population sample of women between 45 and 64 years of age was ... | 18,818,032 |
Rupture of the pectoralis major: a case report and review. | Rupture of the pectoralis major muscle is a rare clinical entity that is becoming more common due to the increasing popularity of weightlifting and recreational sports. Due to the rarity of this condition, it may be missed at initial presentation and inappropriately treated, potentially leading to increased disability.... | 18,818,044 |
Dopaminergic and serotonergic activity in neostriatum and nucleus accumbens enhanced by intranasal administration of testosterone. | Testosterone was administered intranasally in anesthetized male rats, and its effects on the activity of dopaminergic and serotonergic neurons in the neostriatum and nucleus accumbens were assessed by means of microdialysis and HPLC. The treatment (0.5, 1.0 or 2.0 mg/kg of testosterone or vehicle, 10 microl volume) was... | 18,818,056 |
Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosis. | A series of 3beta-hydroxy steroid analogues possessing a contracted cyclopentane B-ring were prepared based on the initial activity screening of a recently reported naturally occurring marine 5(6-->7)abeo-sterol against Mycobacterium tuberculosis. All of the novel ring B abeo-sterols synthesized showed good inhibito... | 18,818,073 |
Study of efficacy of miltefosine and allopurinol in dogs with leishmaniosis. | Visceral leishmaniosis is a life-threatening disease of medical, social and economic importance in endemic areas. It is an opportunistic infection in immunocompromised patients, including human immunodeficiency virus-positive subjects. Dogs are the main reservoir of Leishmania infantum. The aim of this study was to eva... | 18,818,112 |
[Axillary nerve schwannoma (case report)]. | The schwannoma is a benign tumour that can be eradicated; it usually occurs in the peripheral nerves of the upper limb. We report an exceptional localization in the axillary nerve. The diagnosis is based on the typical MRI appearance: in addition, confirmation of the diagnosis has to be made by histological examination... | 18,818,115 |
[Double simultaneous fingertip metastasis of an epidermoid carcinoma. A case report]. | Fingertip metastases are rare. The authors report the case of a patient with an epidermoid carcinoma of the larynx who presented with two separate finger pulp metastases in each hand. According to the literature this seems a very unusual occurrence. This diagnosis must be considered in the differential diagnosis of eve... | 18,818,116 |
Mechanisms of proteasome inhibitor action and resistance in cancer. | Proteasome inhibitors (PIs), such as bortezomib, carfilzomib or NPI-0052, have excellent clinical activity in patients with multiple myeloma and mantle cell lymphoma, and they are currently being evaluated in combination with other agents in patients with solid tumors. Although they exert broad effects on cancer cells,... | 18,818,117 |
Changes in tissue-Doppler echocardiographic assessment of left ventricular filling during NT-proBNP guided heart failure treatment titration: a pilot study. | Although brain natriuretic peptide (BNP) and E/Ea are closely related in heart failure (HF) patients and may be helpful to guide HF therapy, the response of E/Ea to changes in BNP over several weeks of intensive HF treatment optimisation is unknown. This study was designed to investigate this relationship. In 17 patien... | 18,818,124 |
The development of perioperative practices for liver transplantation: advances and current trends. | Transplantation is a young medical specialty that has grown rapidly over the past 50 years. Anesthesiologists, surgeons and hepatologists are all essential partners in the process of determining patient outcome. Each specialty has made landmark improvements in patient outcome. However, there is still variability in pra... | 18,818,135 |
Pyogenic liver abscess associated with septic pulmonary embolism. | Septic pulmonary embolism (SPE) is one of the metastatic foci of pyogenic liver abscess. The purpose of this study was to investigate the clinical presentations of, and management options for patients with pyogenic liver abscess complicated with SPE. A retrospective chart review was conducted from January 1, 1999 to De... | 18,818,136 |
Determination of trans fatty acid levels by FTIR in processed foods in Australia. | Health authorities around the world advise 'limiting consumption of trans fatty acid', however in Australia the trans fatty acid (TFA) content is not required to be listed in the nutrition information panel unless a declaration or nutrient claim is made about fatty acids or cholesterol. Since there is limited knowledge... | 18,818,158 |
Multiple micronutrient deficiencies persist during early childhood in Mongolia. | Data on the prevalence of micronutrient deficiencies in children in Mongolia is limited. We therefore determined the prevalence of anaemia, iron deficiency anaemia (IDA), and deficiencies of iron, folate, vitamin A, zinc, selenium, and vitamin D among young Mongolian children. Anthropometry and non-fasting morning bloo... | 18,818,163 |
High fish consumption in French Polynesia and prenatal exposure to metals and nutrients. | French Polynesians consume high quantities of fish and are therefore exposed to seafood-related contaminants such as mercury (Hg) or lead (Pb) and nutrients such as iodine, selenium and long chain polyunsaturated fatty acids (LC-PUFAs). As the developing foetus is sensitive to contaminants and nutrients, a cross-sectio... | 18,818,168 |
The 2nd International Conference on East-West Perspectives on Functional Foods: Science, Innovations and Claims. | The 2nd International Conference on East-West Perspective on Functional Foods held in Kuala Lumpur, Malaysia, on November, 2007, discussed the current work on some traditional Asian foods and new technologies that offer both challenges and opportunities for functional foods. The highlight of the conference was on the c... | 18,818,176 |
Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice. | In humans, MPV17 mutations are responsible for severe mitochondrial depletion syndrome, mainly affecting the liver and the nervous system. To gain insight into physiopathology of MPV17-related disease, we investigated an available Mpv17 knockout animal model. We found severe mtDNA depletion in liver and, albeit to a le... | 18,818,194 |
A functional Ser(413)/Ser(413) PAI-2 polymorphism is associated with susceptibility and damage index score in systemic lupus erythematosus. | Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser(413)/Cys(413) PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subje... | 18,818,228 |
A review of the trials comparing carotid endarterectomy and carotid angioplasty and stenting. | In the last decade, carotid artery angioplasty and stenting (CAS) has gained popularity as an alternative to carotid endarterectomy (CEA) for the treatment of carotid stenosis, particularly in patients who are at high operative risk. CAS offers the advantage of being a less invasive procedure, potentially minimizing th... | 18,818,232 |
Predictors of long-term major adverse cardiac events and clinical restenosis following elective percutaneous coronary stenting. | Limited data exist regarding the predictors of long-term clinical outcomes following elective percutaneous coronary intervention (PCI) in the current era of stenting. The authors investigated the predictors of major adverse cardiac events (MACE) and clinical restenosis in 740 consecutive patients who underwent successf... | 18,818,239 |
Benefits of low-intensity pain-free treadmill exercise on functional capacity of individuals presenting with intermittent claudication due to peripheral arterial disease. | Patients with intermittent claudication due to peripheral arterial disease (PAD) experience muscle aching during walking secondary to ischemia. The purpose of this study was to examine the effects of low-intensity pain-free exercise (LIPFE) on functional capacity of individuals with PAD. A total of 12 participants with... | 18,818,240 |
A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. | We have previously shown that a number of naturally occurring phytoestrogens and derivatives were effective to induce some measures of neuroprotective responses but at a much lower magnitude than those induced by the female gonadal estrogen 17beta-estradiol. In the present study, we sought to investigate whether a comb... | 18,818,291 |
S4-based voltage sensors have three major conformations. | Voltage sensors containing the charged S4 membrane segment display a gating charge vs. voltage (Q-V) curve that depends on the initial voltage. The voltage-dependent phosphatase (Ci-VSP), which does not have a conducting pore, shows the same phenomenon and the Q-V recorded with a depolarized initial voltage is more sta... | 18,818,307 |
Assembling materials with DNA as the guide. | DNA's remarkable molecular recognition properties and structural features make it one of the most promising templates to pattern materials with nanoscale precision. The emerging field of DNA nanotechnology strips this molecule from any preconceived biological role and exploits its simple code to generate addressable na... | 18,818,351 |
The coevolution of cultural groups and ingroup favoritism. | Cultural boundaries have often been the basis for discrimination, nationalism, religious wars, and genocide. Little is known, however, about how cultural groups form or the evolutionary forces behind group affiliation and ingroup favoritism. Hence, we examine these forces experimentally and show that arbitrary symbolic... | 18,818,361 |
Hyaluronan-mediated leukocyte adhesion and dextran sulfate sodium-induced colitis are attenuated in the absence of signal transducer and activator of transcription 1. | Inflammatory bowel disease is a chronic inflammatory condition of the intestinal mucosa whose etiology is unclear but is likely to be multifactorial. We have shown previously that an increased amount of hyaluronan (HA) is present both in the inflamed mucosa of inflammatory bowel disease patients and in isolated human c... | 18,818,378 |
Pioglitazone inhibits the expression of inflammatory cytokines from both monocytes and lymphocytes in patients with impaired glucose tolerance. | The current study determines whether pioglitazone (PIO) therapy reduces both monocyte and lymphocyte inflammatory activity and their ability to induce inflammation in other tissues. Monocyte and lymphocyte cytokine gene and protein expression of interleukin (IL)-6 were first shown to be greater in subjects with impaire... | 18,818,415 |
Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. | Previous studies demonstrated increased levels of cysteine proteases cathepsins in serum and adipose tissues from obese patients. We now provide evidence from a mouse model of obesity to suggest a direct participation of cathepsin K (CatK) in mouse body weight gain and glucose metabolism. Using real-time polymerase cha... | 18,818,416 |
Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis. | Endothelial progenitor cells are currently identified either by their surface antigen expression or by their generation of early colonies in culture (CFU-Hill). Another population, endothelial colony-forming cells (ECFCs), has strong vessel-forming capacity but is less well characterized. Given the potential usefulness... | 18,818,419 |
Chemokines in vascular dysfunction and remodeling. | Vascular remodeling stands for structural changes of the vessel wall in response to various noxious stimuli, which results in reorganization of the vessel wall architecture. Luminal narrowing because of neointima formation and constrictive remodeling leading to hypoperfusion is the most relevant clinical effect. Smooth... | 18,818,421 |
Semitendinosus tendon graft versus a modified Weaver-Dunn procedure for acromioclavicular joint reconstruction in chronic cases: a prospective comparative study. | Biomechanical studies comparing various surgical techniques for acromioclavicular joint reconstruction have reported that semitendinosus tendon graft for coracoclavicular ligament reconstruction provides a substantial improvement in initial stability and a load-to-failure equivalent to the intact coracoclavicular ligam... | 18,818,433 |
Death, dropout, and longitudinal measurements of cognitive change in old age. | During a 20-year longitudinal study of cognitive change in old age 2,342 of 5,842 participants died and 3,204 dropped out. To study cognitive change as death approaches, we grouped participants by survival, death, dropout, or dropout followed by death. Linear mixed-effects pattern-mixture models compared rates of cogni... | 18,818,441 |
Effects of sensorimotor adaptation training on functional mobility in older adults. | The goal of this study was to determine if prolonged exposure to perceptual-motor mismatch increased adaptability and retention of balance in older adults. Sixteen adults, aged 66 to 81 years, were randomized to one of two groups: either the control group (n=8) or the experimental group (n=8). Both groups first complet... | 18,818,444 |
Dental education in Peru. | This paper provides information about Peru's dental history and dental school system, including the curriculum and dental licensure. With the increase in the number of dental schools in Peru, the number of dentists is also increasing. Until 1965, Peru had only three dental schools; currently, there are 14. Four of thes... | 18,818,472 |
Use of mineral trioxide aggregate in the open apex of a maxillary first premolar. | Mineral trioxide aggregate (MTA) has shown potential as a root-end filling material. This clinical case describes the successful treatment of a premolar with an open apex using MTA and the warm gutta-percha technique. The results suggested that MTA may be used as an apical filling material in permanent teeth with multi... | 18,818,475 |
Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system. | We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this peptide has been shown to be safe in clinical trials for inflammatory bo... | 18,818,478 |
Kidney transplantation improves sleep-related breathing in hemodialysis patients. | To assess whether kidney transplantation improves sleep-related breathing disorders associated with hemodialysis. A prospective study was carried out using full-night polysomnography. Nine hemodialysis patients (7 men and 2 women, aged 42 +/- 16.2 years, BMI 26 +/- 3.7) who later received a successful kidney transplant... | 18,818,490 |
X-ray structure of the complex of regulatory subunits of human DNA polymerase delta. | The eukaryotic DNA polymerase delta (Pol delta) participates in genome replication, homologous recombination, DNA repair and damage tolerance. Regulation of the plethora of Pol delta functions depends on the interaction between the second (p50) and third (p66) non-catalytic subunits. We report the crystal structure of ... | 18,818,516 |
The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. | MicroRNAs (miRNAs) are noncoding RNAs that regulate numerous target genes through a posttranscriptional mechanism and thus control major developmental pathways. The phylogenetically conserved let-7 miRNA regulates cell proliferation and differentiation, thus functioning as a key regulator of developmental timing in C. ... | 18,818,519 |
Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner. | Although capsaicin, a pungent component of red pepper, is known to induce apoptosis in several types of cancer cells, the mechanisms underlying capsaicin-induced cytotoxicity are unclear. Here, we showed that dihydrocapsaicin (DHC), an analog of capsaicin, is a potential inducer of autophagy. DHC was more cytotoxic tha... | 18,818,525 |
Influenza activity--United States and worldwide, May 18-September 19, 2008. | During May 18-September 19, 2008, influenza A (H1), influenza A (H3), and influenza B viruses were detected worldwide and were identified sporadically in the United States. This report summarizes influenza activity in the United States and worldwide since the last update and reviews the new influenza vaccine recommenda... | 18,818,585 |
Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition. | The obligate intracellular parasite Toxoplasma gondii, a member of the phylum Apicomplexa that includes Plasmodium spp., is one of the most widespread parasites and the causative agent of toxoplasmosis. Adhesive complexes composed of microneme proteins (MICs) are secreted onto the parasite surface from intracellular st... | 18,818,666 |
Complexity of VEGF responses in skin carcinogenesis revealed through ex vivo assays based on a VEGF-A null mouse keratinocyte cell line. | Vascular endothelial growth factor (VEGF-A) is a critical player in cutaneous angiogenesis. However, the relative contribution of VEGF-A from different sources including epithelial and mesenchymal cells has not been fully characterized during skin repair and tumorigenesis. Moreover, the actual involvement of other vasc... | 18,818,673 |
Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse. | Natural IgM are involved in numerous immunological functions but the genetic factors that control the homeostasis of its secretion and upholding remain unknown. Prompted by the finding that C57BL/6 mice had significantly lower serum levels of IgM when compared with BALB/c mice, we performed a genome-wide screen and fou... | 18,818,690 |
Adaptation and selective information transmission in the cricket auditory neuron AN2. | Sensory systems adapt their neural code to changes in the sensory environment, often on multiple time scales. Here, we report a new form of adaptation in a first-order auditory interneuron (AN2) of crickets. We characterize the response of the AN2 neuron to amplitude-modulated sound stimuli and find that adaptation shi... | 18,818,723 |
Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses. | The highly pathogenic avian influenza (HPAI) H5N1 virus lineage has undergone extensive genetic reassortment with viruses from different sources to produce numerous H5N1 genotypes, and also developed into multiple genetically distinct sublineages in China. From there, the virus has spread to over 60 countries. The ecol... | 18,818,732 |
Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. | The class-3 semaphorins (sema3s) include seven family members. Six of them bind to neuropilin-1 (np1) or neuropilin-2 (np2) receptors or to both, while the seventh, sema3E, binds to the plexin-D1 receptor. Sema3B and sema3F were previously characterized as tumor suppressors and as inhibitors of tumor angiogenesis. To d... | 18,818,766 |
Incidental colorectal computed tomography abnormalities: would you send every patient for a colonoscopy? | The clinical significance of colorectal wall thickening (CRWT) in patients undergoing abdominal computed tomography (CT) has not yet been definitively established. To compare alleged findings on abdominal CT with those of a follow-up colonoscopy. Ninety-four consecutive patients found to have large-bowel abnormalities ... | 18,818,789 |
Latent lymphocytic enterocolitis associated with celiac disease manifesting after resection for colon cancer: case report and review of the literature. | Lymphocytic colitis, a cause of chronic watery diarrhea, is histologically characterized by increased intraepithelial lymphocytosis. Studies have associated this disorder with celiac disease, although there are no reports of patients with both lymphocytic colitis and colon cancer. The present case report describes a pa... | 18,818,792 |
Droplet-based microfluidic system for individual Caenorhabditis elegans assay. | A droplet-based microfluidic system integrating a droplet generator and a droplet trap array is described for encapsulating individual Caenorhabditis elegans into a parallel series of droplets, enabling characterization of the worm behavior in response to neurotoxin at single-animal resolution. | 18,818,795 |
Open micro-fluidic system for atomic force microscopy-guided in situ electrochemical probing of a single cell. | Ultra-sharp nano-probes and customized atomic force microscopy (AFM) have previously been developed in our laboratory for in situ sub-cellular probing of electrochemical phenomena in living plant cells during their photosynthesis. However, this AFM-based electrochemical probing still has numerous engineering challenges... | 18,818,800 |
Scanning tunneling microscopy as a tool to study catalytically relevant model systems. | The surface science approach to catalysis, pioneered by 2007 Nobel Laureate in chemistry Gerhard Ertl, has helped revolutionize our understanding of heterogeneous catalysis at the atomic level. In this tutorial review we show how the scanning tunnelling microscope (STM), in combination with this surface science approac... | 18,818,822 |
Oxide ultra-thin films on metals: new materials for the design of supported metal catalysts. | Ultrathin oxide films on metals offer new opportunities for the design of supported nanoclusters with potential use in catalysis. This requires a characterization at the atomistic level of the structure and composition of the thin film, of its morphology and defect structure. A proper selection of metal/oxide interface... | 18,818,825 |
Microkinetic simulations of the oxidation of CO on Pd based nanocatalysis: a model including co-dependent support interactions. | The catalysed oxidation of CO using mass-selected Pd(13) clusters supported on thin MgO films was modelled using a microkinetic simulation of the reaction. The model of the system includes reverse spill-over calculations which were intrinsically incorporated into the formulation of the kinetics. The spill-over model is... | 18,818,841 |
Dissociations of copper(II)-containing complexes of aromatic amino acids: radical cations of tryptophan, tyrosine, and phenylalanine. | The dissociations of two types of copper(II)-containing complexes of tryptophan (Trp), tyrosine (Tyr), or phenylalanine (Phe) are described. The first type is the bis-amino acid complex, [Cu(II)(M)(2)].(2+), where M = Trp, Tyr, or Phe; the second [Cu(II)(4Cl-tpy)(M)].(2+), where 4Cl-tpy is the tridendate ligand 4'-chlo... | 18,818,845 |
Microbiological assessment of the ultraviolet screening effect of sunscreen preparations. | The purpose of this study was the development of a microbiological method for the assessment of the ultraviolet (UV) screening effect of sunscreen preparations and determination of their sun protection factor. The method is based on the lethal effect of UV radiation on Escherichia coli (E. coli ) and the protective abi... | 18,818,849 |
Bone marrow transplantation for severe aplastic anemia secondary to temozolomide. | Radiotherapy (RT) and concomitant/adjuvant therapy with temozolomide (Temodar) is a common treatment regimen for children and adults with glioma. Although temozolomide is generally well tolerated with temporary myelosuppression as the primary dose-limiting toxicity, irreversible bone-marrow aplasia after treatment with... | 18,818,880 |
Innate immunity in the pathogenesis of polytropic retrovirus infection in the central nervous system. | Neuroinflammation, including astrogliosis, microgliosis, and the production of proinflammatory cytokines and chemokines is a common response in the central nervous system (CNS) to virus infection, including retrovirus infection. However, the contribution of this innate immune response in disease pathogenesis remains un... | 18,818,884 |
Perioperative use of recombinant factor VII to prevent intraoperative aneurysm rupture in high risk patients: a preliminary safety evaluation. | The authors present a safety evaluation of the perioperative use of recombinant activated factor VII (rFVIIa) in a series of subarachnoid hemorrhage patients undergoing microsurgical aneurysm clipping. We performed a retrospective chart review of the records of 18 consecutive subarachnoid hemorrhage patients who underw... | 18,818,887 |
Magnetic resonance imagination of the peroneus longus tendon after anterior cruciate ligament reconstruction. | Several studies report that tendons can regenerate after harvesting. These studies have been performed especially in patellar and hamstring tendons. At our institution, 10 cm length of full thickness peroneus longus tendon has been harvested to reconstruct torn anterior cruciate ligament since 1997 as a different graft... | 18,818,901 |
Positional and directional preponderances in vection. | We examined the biases in vection strength caused by motion direction (temporonasal vs. nasotemporal motion) and position of stimulus presentation (nasal and temporal semi-retinas) to investigate a subcortical contribution to vection. These biases have been identified for optokinetic nystagmus (OKN) and are acknowledge... | 18,818,907 |
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