title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Acute rib fracture diagnosis in an infant by US: a matter of child protection. | Rib fractures in infants and children are highly specific for inflicted injury in the absence of a major accidental injury or underlying bone disorder. We present a 9-week-old infant diagnosed with an acute rib fracture by US at the site where physicians palpated chest wall crepitus when no rib fractures had been visua... | 18,818,912 |
Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysis. | MicroRNAs (miRNAs) are small (approximately 22 nucleotides) regulatory RNAs which play fundamental roles in many human diseases, including cancer. There is no report on the miRNA expression profile of retinoblastoma. This work was undertaken to identify differentially expressed miRNAs in human retinoblastoma tissues by... | 18,818,933 |
Local recurrence of disease after unplanned excisions of high-grade soft tissue sarcomas. | Unplanned excisions of soft tissue sarcomas occur with alarming frequency and result in high rates of residual disease, potentially affecting patient prognosis. To determine if unplanned excisions and residual disease status at tumor bed excision increased local recurrence rates and predicted disease-specific patient s... | 18,818,981 |
Affect regulation, social context, and sexual intercourse in adolescents. | This study examined trajectories of positive and negative affect surrounding penile-vaginal sexual intercourse (sex) in adolescents and explored the influence of companionship on these trajectories. Using a handheld computer, sexually active adolescents (N = 67) reported momentary affect and sex events in response to s... | 18,818,996 |
Contribution of position alpha4S336 on functional expression and up-regulation of alpha4beta2 neuronal nicotinic receptors. | Phosphorylation of the nicotinic acetylcholine receptor (nAChR) is believed to play a critical role in its nicotine-induced desensitization and up-regulation. We examined the contribution of a consensus PKC site in the alpha4 M3/M4 intracellular loop (alpha4S336) on the desensitization and up-regulation of alpha4beta2 ... | 18,818,999 |
Are preferences in emotional processing affected by distraction? Examining the age-related positivity effect in visual fixation within a dual-task paradigm. | Recent research has suggested that age-related positivity effects are eliminated under conditions of dual-task load (Knight et al., 2007, Emotion, 7, 705; Mather & Knight, 2005, Psychology and Aging, 20, 554), because the cognitive control resources necessary to enact such preferences are not available when individ... | 18,819,026 |
Testosterone and bioavailable testosterone help to distinguish between mild Cushing's syndrome and polycystic ovarian syndrome. | Women with Cushing's syndrome (CS) and polycystic ovarian syndrome (PCOS) may present with similar symptoms. Subjects with mild CS lack clinical stigmata of classical CS and often have normal laboratory tests measuring hypercortisolism. Thus, distinguishing mild CS from PCOS may be difficult. We hypothesized that eithe... | 18,819,057 |
Synthesis of fluoroneplanocin A. | Fluoroneplanocin A, designed as a potent mechanism-based irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH), is synthesized from D-ribose via a key D-cyclopentenone intermediate. This intermediate is synthesized using a stereoselective Grignard reaction, a ring-closing metathesis (RCM) reaction, and oxida... | 18,819,082 |
Analysis of endocytic trafficking by single-cell fluorescence ratio imaging. | The post-endocytic sorting of internalized membrane proteins plays a critical role in numerous physiological processes, including receptor desensitization, degradation of non-native plasma membrane proteins, and cell surface retrieval of receptors from early endosomes upon ligand dissociation. Here, we describe a fluor... | 18,819,089 |
Use of digitoxin and digoxin as internal standards in HPLC analysis of triterpene saponin-containing extracts. | Saponins are widely distributed complex plant glycosides possessing a variety of structure-dependent bioactivities. Quantitation of individual saponins is difficult due to lack of available standards, mainly as a consequence of purification difficulties. Determination of total saponin content can be problematic, often ... | 18,819,105 |
Percutaneous rescue of left ventricular embolized amplatzer septal occluder device. | Transcatheter atrial septal defect (ASD) closure has proven to be safe and effective, and it is rapidly becoming the standard treatment for secundum-type ASDs. However, device embolization occurs in about 0.55% of cases, regardless of ASD and device size and/or physician's expertise. Percutaneous retrieval of the embol... | 18,819,121 |
Starch and albumin mixture as replacement fluid in therapeutic plasma exchange is safe and effective. | Therapeutic plasma exchange (TPE) is an effective treatment in Myasthenia gravis (MG) and Guillain-Barré syndrome (GBS) and 5% human albumin is the replacement fluid of choice; however, it is expensive. More recently, it has been suggested that starch is a safe and cheaper choice to human albumin. To evaluate our 5-yea... | 18,819,155 |
Elimination of menstrual-related migraine beneficially impacts chronification and medication overuse. | This study seeks to determine whether menstrual-related migraine (MRM) has a discrete, attributable impact on migraine chronicity and medication overuse. Menstrual-related migraine can be a disabling headache on its own; but when seen in headache clinics, it is often enmeshed in the setting of chronic migraine (CM) and... | 18,819,179 |
Functional MRI in malformations of cortical development: activation of dysplastic tissue and functional reorganization. | Functional neuroimaging and electrophysiological studies suggest that dysplastic neural tissue in malformations of cortical development may participate in task performance, and that functional organization can be altered beyond visible lesion boundaries. The aim of this work was to investigate cortical function in a he... | 18,819,184 |
Leadership, civility, and the 'no jerks' rule. | Nursing organizations and hospitals are not immune from the ravages of incivility. Toxic behavior can range from the very serious bullying and sabotage of very destructive people to the annoying and hard to cope behavior of just plain jerks. When a practice does not have a clearly defined "No Jerk" rule and infrastruct... | 18,819,229 |
Drug-induced nephrotoxicity. | Drugs are a common source of acute kidney injury. Compared with 30 years ago, the average patient today is older, has more comorbidities, and is exposed to more diagnostic and therapeutic procedures with the potential to harm kidney function. Drugs shown to cause nephrotoxicity exert their toxic effects by one or more ... | 18,819,242 |
Different cardiovascular potential of adult- and fetal-type mesenchymal stem cells in a rat model of heart cryoinjury. | Efficacy of adult (bone marrow, BM) versus fetal (amniotic fluid, AF) mesenchymal stem cells (MSCs) to replenish damaged rat heart tissues with new cardiovascular cells has not yet been established. We investigated on the differentiation potential of these two rat MSC populations in vitro and in a model of acute necrot... | 18,819,256 |
[Role of water channels in the regulation of the volume of principal cells of rat kidney collecting ducts in hypoosmotic medium]. | The effect of plasma membrane water permeability on the rate of changes in the volume of principal cells of collecting ducts of the outer substantia medullaris under conditions of hypoosmotic shock has been studied. Changes in cell volume were studied by the fluorescent method. It was shown that the hypotonic shock ind... | 18,819,288 |
[Ultrasound-induced myocardial preconditioning: analysis of its effectiveness and mechanisms]. | It has been shown that exposure of the isolated rat heart perfused according to Langendorff to therapeutic ultrasound (210 kHz and 0.5-1.5 W/cm2 ) induces a cardioprotective response similar to ischemic preconditioning. This reduces the infarct size and improves the postischemic systolic and diastolic function. The ATP... | 18,819,289 |
Epidemiology of gout. | The incidence and prevalence of gout are rising, likely as a result of a changing pattern of risk factors. At-risk populations are growing, due to the fact that people are living longer. Longevity and current dietary and lifestyle choices have also contributed to increased rates of comorbidities associated with hyperur... | 18,819,329 |
[Plasma levels of cytokines in patients with active infiltrative pulmonary tuberculosis]. | The levels of interferon-y (IFN-gamma), tumor necrosis factor-gamma (TNF-alpha), and interleukin-8 (IL-8) and their changes during chemotherapy and laser chemotherapy were studied in 97 patients with active infiltrative pulmonary tuberculosis, by taking into account Mycobacterium tuberculosis (MBT) sensitivity to chemi... | 18,819,336 |
[Fullerenes in the treatment of respiratory disorders]. | Diseases of respiratory organs constitute a serious socio-medical problem in this country due to high morbidity, mortality, and disability rates. The development of medical nanotechnlogies opens up new prospects for the improvement of treatment and prevention of these pathologies. Of special interest is application of ... | 18,819,341 |
[Chronic constipation: current view of the problem]. | The authors propose the definition of chronic constipations (CC) and present data on their incidence and classification along with a concise review of physiology and motor-evacuation function of the colon and defecation act. Pathogenesis and clinical symptoms of different forms of functional and organic CC are discusse... | 18,819,342 |
[Tissue factor molecules and some other indices of coagulation hemostasis in patients with rheumatic heart disease]. | This comparative study of interleukins, tissue factor activity, and certain parameters of coagulation hemostasis included patients with rheumatic heart disease. It revealed an increased production of proinflammatory cytokines including interleukin-1b (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in all groups... | 18,819,347 |
[Causes of pain in the knee joint]. | Pain in the knee joint is one of the commonest complaints for which people seek an advice of different medical specialists. The aim of this study was to elucidate the cause of pain in patients with the alleged diagnosis of "osteoarthrosis" and to develop the relevant diagnostic algorithm. The study included 214patients... | 18,819,352 |
[New conceptions in complex management of spine trauma patients including reconstructive microsurgery and succeeding rehabilitation]. | This work is been based upon the experience of performing 100 reconstructive microsurgical operations with transplantation of combined vascular-neural autografts, in 24 cases--with introduction cellular material into zone of transplantation. The complex approach aimed to creating optimal conditions for the functional r... | 18,819,357 |
[Biomechanics of pelvic ring and its structural elements]. | Calculations and diagrams of the force distribution in pelvic bones' zone are presented. In persons without injuries and skeletal abnormalities all forces functioning on the pelvic ring are shown to be in balance. Proposed method of calculations enables to detect the treatment tactics (either conservative or operative ... | 18,819,360 |
[Effect of chlorine-sodium hydrocarbonate mineral water on the gastric secretory function in subjects with various daily motor activity patterns]. | Effect of Shadrinskaya ID mineral water on the gastric secretory function was evaluated in wrestlers and subjects unengaged in sports activities. Characteristics of the observed functional response of the digestive system provided a deeper insight into the mechanisms by which mineral water along with the controlled mus... | 18,819,363 |
[Antagonistic activity of bacteria from Bacillus genus against dermatophyte fungi]. | Antagonistic properties of the strain Bacillus subtilis IB-54 with respect to dermatophyte fungi Trichophyton rubrum, T. mentagrophytes var. gypseum, Microsporum canis was studied. The studied strains of bacilli effectively inhibited growth and development of dermatophytes when were cultivated on the media containing d... | 18,819,402 |
[Role of innate immunity receptors in development of acute myocardial infarction]. | To assess influence of toll-like receptors (TLR) ligands on the production of proinflammatory cytokine (TNFalpha) by peripheral blood mononuclear cells in patients with acute myocardial infarction (AMI). Peripheral blood mononuclear cells (PBMC) obtained from 13 patients with AMI on 1st and 14th day and from 17 healthy... | 18,819,410 |
[Expression of mRNA for corticoliberin and vasopressin in hypothalamus and amygdala on the background of administration of psychoactive drugs in rats]. | Wistar male rats were injected intraperitoneally for 4 days in elevated doses with: (1) physiological saline (control; 0.1 - 0.2 - 0.4 - 0.8 ml/rat), (2) amphetamine (0.5 - 1.0 - 2.0 - 4.0 mg/kg); (3) fentanyl (0.00625 - 0.0125 - 0.025 - 0.05 mg/kg), (4) 40% aqueous ethanol solution (0.5 - 1.0 - 2.0 - 4.0 g/kg), (5) et... | 18,819,432 |
[Infectivityand resistance to antibiotics of non-fermentative rods isolated from patients hospitalised in pediatric center of Lower Silesia in Wrocław in the years 2000-2006]. | The aim of this study was to evaluate the frequency of isolation and antimicrobial resistance testing of non-fermentative rods isolated from clinical specimens from patients hospitalized in Korczak Pediatric Center of Lower Silesia in Wrocław. The susceptibility of bacteria to selected antibiotics was determined. The c... | 18,819,446 |
[Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. | The effects of GABA - docosahexaenoyldopamine (DHED) conjugate on the cerebral haemodynamics and thrombocyte aggregation were evaluated and compared to these of docosahexaenoyldopamine alone. The GABA - DHED conjugate was shown to significantly enhance the cerebral circulation in rats with a model of global transient c... | 18,819,437 |
[Anticoagulant activity of arabinogalactane sulfate and cedar bark extract studied in vitro]. | We have studied in vitro the ability of the Siberian cedar crust (SCC) extract (Pinus sibirica Du Tour) and arabinogalactan sulphate (AGS) extracted from wood of Siberiam pine-tree (Larix sibirica Ledeb.) to increase the human blood plasma coagulation time and also to inhibit the amydolytic activity of thrombin (aIIa) ... | 18,819,438 |
[Progress in small-molecule inhibitors of Bcl-2 family proteins]. | Apoptosis is an essential factor in keeping homeostasis of the organism. Apoptosis is regulated by a series of cytokines. Bcl-2 family proteins are key regulators of apoptosis. The Bcl-2 family includes both anti- and pro-apoptotic proteins with opposing biological functions. Their interaction regulates the transmissio... | 18,819,468 |
[Optimizing expression and purification of recombinant Salvia miltiorrhiza copalyl diphosphate synthase protein in E. coli and preparation of rabbit antiserum against SmCPS]. | The expression plasmid pET32CPS harboring SmCPS gene was transformed into E. coli BL21 trxB (DE3) resulting in recombinant strain E. coli [pET32CPS]. The induction of E. coli [pET32CPS] in different temperatures, induction time, IPTG concentrations and A600 values of E. coli were performed. The optimal expression condi... | 18,819,484 |
[Progress in the research of stanniocalcin]. | Stanniocalcin (STC) is a glycoprotein hormone first identified in bony fish in which it regulates calcium and phosphate homeostasis. Stanniocalcin is also identified in human and mammals and is named STC1 and STC2 by the sequence of finding. There are two forms of STC produced by the STC1 gene; a 50 kD polypeptide know... | 18,819,490 |
[Progress in signal transduction pathways mediating effects of angiotensin II in endothelial cells]. | Angiotensin II (Ang II) not only mediates the effects of vasoconstriction and blood pressure regulation, but is also implicated in inflammation, endothelial dysfunction, atherosclerosis, hypertension and congestive heart failure. Ang 1I activates pathways of MAPK, NADPH and ROS, non-receptor tyrosine kinases and recept... | 18,819,491 |
[Two unusual ulcers in one patient]. | A 39-year-old Antillean woman was referred by her family doctor to an oral and maxillofacial surgeon because of an unusual and painful ulcer in the buccal region of the first left mandibular molar. Earlier that day, she was diagnosed as HIV-positive. The ulcer was diagnosed as an atypical necrotising ulcerating periodo... | 18,819,509 |
[The TRIP database. A valuable source of literature on oral health]. | Locating the desired evidenced-based literature via the internet is usually time-consuming and not particularly straight-forward. Websites offering evidence-based information should be accessible, efficient and user friendly. Many of these websites, however, only make their own content available, making it necessary to... | 18,819,510 |
Insulin availability from mucoadhesive tablets. | The widespread implementation of peptides as drugs encounters numerous obstacles, the main being invasive and inconvenient parenteral administration. Oral transmucosal administration is one of the possible alternatives, valuable for its noninvasiveness and easy accessibility. The aim of our study was to determine the i... | 18,819,517 |
Preparation, characterization and optimization of probucol self-emulsified drug delivery system to enhance solubility and dissolution. | The main purposes of this work were to prepare, characterize and optimize a self-emulsified drug delivery system of probucol (PBSEDDS) with enhanced dissolution and better chance for oral absorption. The methods included determination of the solubility of probucol in different oils, surfactants and co-surfactants using... | 18,819,518 |
Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell. | To investigate the effect and mechanism of nociceptin/orphanin FQ (OFQ) reversing multi-drug resistance of K562/ADM cells in vitro. MTT assay, Wright staining, flow cytometry, transmission electron microscope and gel electrophoresis were used to evaluate the effect and mechanism of OFQ in reversing multi-drug resistanc... | 18,819,522 |
Immunogenicity of lipid sustained release implants containing imiquimod, alpha-galactosylceramide, or Quil-A. | The aim of this study was to investigate and compare the immunogenicity of liposome-forming, sustained release lipid implants containing either an alpha-galactosylceramide (alpha-GalCer) analogue, imiquimod or Quil-A (QA) as adjuvants. Ovalbumin (OVA) was used as a model antigen. Groups of C57Bl/6 mice were subcutaneou... | 18,819,523 |
Chemotaxonomic studies on Aegilops L. (Poaceae) in Iran. | This study, using seed storage protein electrophoresis, evaluates the taxonomic status of the Aegilops L. species and the variation between the species. Therefore, with the seeds of seven species and 46 accessions of Aegilops, the prolamin was separated. On the base of the banding patterns, the cluster analysis among t... | 18,819,527 |
Expression of biologically active measles virus hemagglutinin glycoprotein by a recombinant baculovirus. | In this study, one of the measles virus membrane proteins, named hemagglutinin (H) which has a key role in tropism, receptor binding, hemagglutinating activity and also induction of protective immunity against viral infection, was expressed by the baculovirus expression system using specific plasmid (pDONR221) to produ... | 18,819,529 |
The study of seed yield and seed yield components of lentil (Lens culinaris Medik) under normal and drought stress conditions. | In this study yield and seed yield components of twenty lentil (Lens culinaris Medik) genotypes were compared in a split plot RCBD based design with 3 replications at the Zanjan University Research Farmland in 2004. The main plots were lentil planted under drought stress and non stress (irrigation) condition and subplo... | 18,819,573 |
Chemical composition of raw fish consumed in Bahrain. | Nine species (Seriolina nigrofasciata, Siganus canaliculatus, Rhabdosargus haffara, Scomberomorus commerson, Liza alata, Epinephelus areolatus, Plectorhinchus sordidus, Lethrinus nebulosus and Penaeus semislcatus) of raw fish commonly consumed in Bahrain were analyzed for their proximate, mineral and heavy metal conten... | 18,819,593 |
Comparison of four induced molting methods based on subsequent performance and welfare of Single Comb White Leghorn hens. | A total of 400 Single Comb White Leghorn hens at 80 weeks of age were used in present study. Four treatment groups that were consisted of six replications with 10 hens per each replication were considered. In the first treatment, food and water were removed for the first 2, 4, 6 and 8 days. However, on days 3, 5, 7, 9 ... | 18,819,600 |
Phenotypic diversity in Terminalia catappa from South Western Nigeria. | The diversity amongst Teminalia catappa population in two different locations in the Lagos area of South Western Nigeria was investigated. Forty trees were sampled for twenty eight quantitative and twelve qualitative characters. Variability was observed in qualitative characters such as leaf shape and ripe fruit colour... | 18,819,608 |
Vitamin A status of pregnant women in Calabar metropolis, Nigeria. | The vitamin A status of 101 pregnant women attending clinic at the University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria was assessed based on 24 h dietary recall, serum retinol concentration, history of night blindness, physical appearance and clinical eye signs. The study revealed that the mean dietary vit... | 18,819,622 |
Foliar micromorphology of Felicia muricata Thunb., A South African medicinal plant. | The foliar micromorphology of Felicia muricata (Thunb.) Nees (Asteraceae) was observed with the JEOL (JSM-6390LV) Scanning Electron Microscope (SEM). Both the abaxial and adaxial surfaces were characterized by anisocytic stomata which were more prevalent on the abaxial surface than the adaxial surface. The leaves have ... | 18,819,624 |
In vitro evaluation of Penicillium digitatum Sacc strains sensitivity to various fungicides from Jordan. | This investigation is the first report in Jordan, aimed for in vitro evaluation of six fungicides and their combinations, to control the post harvest green mold (Penicillium digitatum) of citrus fruits. Thirty one different concentrations (0.01-3000 microg mL(-1)) of each fungicide, in addition to 6 combined concentrat... | 18,819,638 |
Acclimated biomass that degrades Sulfonated Naphthalene Formaldehyde Condensate. | A number of aerobic species were isolated from textile industry activated sludge wastewater. The bacterial consortium was acclimated during seven days before testing its capacity of Sulfonated Naphthalene-Formaldehyde Condensate (SNFC) recalcitrant compound degradation. SNFC's degradation was evaluated by using differe... | 18,819,646 |
Variation in testicular histology of the spiny tailed lizard Uromastyx aegyptius microlepis during hibernation and active periods. | The testicular histology of the lizard, Uromastyx aegyptius microlepis were varied considerably during hibernation and activity periods, reaching maximum values in summer. The onset of winter induces testicular regression, reduced testis size, testis diameter, diameter and epithelial height of the seminiferous tubules ... | 18,819,651 |
The influence of different hormone concentration and combination on callus induction and regeneration of Rauwolfia serpentina L. Benth. | The influence of media composition on callus induction and subsequent regeneration of Rauwolfia serpentina L. Benth has been studied. High frequency (96.43%) callus induction was obtained when nodal segments from in vitro raised shoots were cultured on MS medium supplemented with 0.5 mg L(-1) BA and 2.0 mg L(-1) NAA. T... | 18,819,656 |
[Role of the French Research Institute for Overseas Development (Institut de Recherche pour le Developpement, IRD)]. | IRD is a French public scientific and technological institution, jointly overseen by the Ministries of Research and Overseas Cooperation. It has three main vocations: research, evaluation and training It meets these objectives by conducting scientific programs, centered around the relationship between humans and their ... | 18,819,682 |
[The Pasteur Institute is mobilized against emerging diseases]. | The Pasteur Institute, founded nearly 120 year ago, is again mobilizing to control emerging and re-emerging infectious diseases (chikungunhya, avia flu, etc.) and also to fight major "classical" infections like AIDS and malaria. | 18,819,683 |
[Alzheimer's disease: from brain lesions to new drugs]. | We review the main therapeutic targets in Alzheimer's disease. Current treatments include cholinesterase inhibitors and the glutamate-modulating drug memantin. Other neurotransmitters such as serotonin, histamine and noradrenaline may also be targeted. Although useful, however, these symptomatic treatments do not preve... | 18,819,689 |
[Forensic psychiatry]. | in France about 700 psychiatrists are licensed to determine criminal responsibility before the courts, in other words to assess whether a criminal was capable of knowing what he or she was doing or of controlling him or herself Criminals who are considered irresponsible are committed to psychiatric hospitals. Criminals... | 18,819,690 |
Micro-stamped surfaces for the patterned growth of neural stem cells. | We present a method for patterning neural stem cells based on pre-patterning polypeptides on a cell-repellent surface (poly(ethylene) oxide-like, PEO-like, plasma-deposited films). The method ensures cell attachment and stability for several weeks, as well as it allows cell migration and differentiation. Various patter... | 18,819,707 |
The quest for orthologs: finding the corresponding gene across genomes. | Orthology is a key evolutionary concept in many areas of genomic research. It provides a framework for subjects as diverse as the evolution of genomes, gene functions, cellular networks and functional genome annotation. Although orthologous proteins usually perform equivalent functions in different species, establishin... | 18,819,722 |
Juvenile pityriasis rubra pilaris: report of 28 cases in Taiwan. | Pityriasis rubra pilaris (PRP) is a papulosquamous dermatosis uncommon in juveniles. Large-scale studies are limited, especially from Asian countries. We sought to analyze the clinical manifestations of juvenile PRP in Taiwanese patients and compare them with reported series in the literature. The diagnosis of juvenile... | 18,819,727 |
[Internal medicine physicians' perception of frequency and impact of corticosteroid-induced adverse events]. | Whereas internal medicine physicians frequently prescribe systemic corticosteroids, it is unknown if they assess adequately the frequency and the discomfort caused by corticosteroid-induced adverse events. Using an e-mail questionnaire sent to the 813 internal medicine physicians, members of the French National Society... | 18,819,732 |
Fluorescence studies on the photophysical properties and encapsulation behavior of acetaminophen in different environments. | A systematic study on the spectroscopy and photophysical properties of widely used analgesic and anti-pyretic drug acetaminophen (NAPAP) was presented using steady state and time-resolved fluorescence spectroscopy. The results in homogeneous solvents were compared with those in bio-mimicking environments of cyclodextri... | 18,819,744 |
[Prolonged fever of unknown origin in Behçet's disease. Pay attention to vessels!]. | Behçet's disease is a systemic vasculitis characterized by the association of recurrent oral and genital ulcers to systemic involvements, particularly ocular, nervous and vascular manifestations. Contrary to other vasculitis, prolonged fever of unknown origin is rare in Behçet's disease. We report a case of a 26-year-o... | 18,819,765 |
Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma. | To evaluate the effects of weight change on asthma control, asthma-related quality of life, number of steroid bursts, and exacerbation of asthma symptoms in a population of adult patients with severe or difficult-to-treat asthma who participated in The Epidemiology and Natural History of Asthma: Outcomes and Treatment ... | 18,819,787 |
Application of parylene-coated quartz crystal microbalance for on-line real-time detection of microbial populations. | A novel technique of applying a quartz crystal microbalance (QCM) sensor to the on-line real-time detection of microbial populations is described. The pQCM sensor was fabricated by depositing di-para-xylene (parylene) over the entire surface of a QCM sensor through a chemical vapor deposition (CVD) process. An electric... | 18,819,789 |
A novel electrochemical immunosensor based on ordered Au nano-prickle clusters. | In this paper, we report a kind of ordered 3D Au nano-prickle clusters by directly electrodeposited on glassy carbon electrode utilizing the spatial obstruction/direction of the polycarbonate membrane. The proposed 3D nanoclusters are applied to fabricate a sandwich-type electrochemical immunosensor with human IgG as a... | 18,819,790 |
[Construction of a recombinant adenovirus expression vector for human renal tumor- associated antigen G250 gene with AdMax system]. | To construct a adevoviral vector harboring human renal tumor-associated antigen G250 gene for transfecting the dendritic cells (DCs) and treating renal tumors. The G250 genes were cloned into the shuttle plasmid pDC316 to construct pDC316-G250, which was cotransfected with the rescue plasmid pBHGlox(delta)E1,3Cre into ... | 18,819,881 |
[Anti-tumor and bystander effects of cationic liposome-mediated CD/5-FC suicide gene system combined with interferon-gamma in vivo]. | To study the antitumor and distant bystander effects of cationic liposome-mediated cytosine deaminase (CD)/5-fluorocytosine (5-FC) suicide gene system combined with interferon-gamma (IFN-gamma) in vivo. Murine hepatoma 22 (H22) cells transfected by CD gene were inoculated subcutaneous in Kunming mice in the left axilla... | 18,819,882 |
[Relationship between apolipoprotein e4 allele and emergence agitation in patients undergoing general anesthesia]. | To investigate the relationship between apolipoprotein e4 allele and emergence agitation (EA) in patients undergoing general anesthesia. A nested cohort study was conducted in elderly patients (over 60 years old) scheduled for major abdominal surgery requiring general anesthesia. A structured interview was conducted in... | 18,819,891 |
[Clinical value of the model for end-stage liver disease score in predicting the prognosis of liver transplantation in patients with end-stage liver disease]. | To assess the value of the model for end-stage liver disease (MELD) in predicting the early-stage outcome of liver transplantation in patients with end-stage liver disease. The MELD scores of 87 liver transplantation recipients with end-stage liver disease were calculated, and their early-stage complications and mortal... | 18,819,907 |
[Comparison study on diagnostic and prognostic value of N-terminal probrain natriuretic peptide and atrium natriuretic peptide in chronic congestive heart failure]. | To investigate the diagnostic and prognostic value of N-terminal probrain natriuretic peptide(NT-proBNP)and atrium natriuretic peptide(ANP)in chronic congestive heart failure. One hundred and eighteen coronary heart disease patients were enrolled in the study. Among them 78 patients were accompanied by heart failure an... | 18,819,908 |
Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY. | Misfolded proteins in the endoplasmic reticulum (ER) are exported to the cytosol for degradation by the proteasome in a process known as ER-associated degradation (ERAD). CPY* is a well characterized ERAD substrate whose degradation is dependent upon the Hrd1 complex. However, although the functions of some of the comp... | 18,819,915 |
A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. | Hypoxia is a prominent feature of solid tumors known to contribute to malignant progression and therapeutic resistance. Cancer cells adapt to hypoxia using various pathways, allowing tumors to thrive in a low oxygen state. Induction of new blood vessel formation via the secretion of proangiogenic factors is one of the ... | 18,819,928 |
Comparative anatomy and morphology of nectar-producing Melastomataceae. | Most neotropical Melastomataceae have bee-pollinated flowers with poricidal anthers. However, nectar rewards are known to be produced in about 80 species in eight genera from four different tribes. These nectar-producing species are pollinated by both vertebrates and invertebrates. The floral morphology and anatomy of ... | 18,819,949 |
Ancient Chinese literature reveals pathways of eggplant domestication. | Changes in key traits occurring during the processes of plant domestication have long been subjects of debate. Only in the case of genetic analysis or with extensive plant remains can specific sets of changes be documented. Historical details of the plant domestication processes are rare and other evidence of morpholog... | 18,819,950 |
Survey, laboratory and statistical methods for the BSAC Resistance Surveillance Programmes. | The British Society for Antimicrobial Chemotherapy (BSAC) Bacteraemia and Respiratory Resistance Surveillance Programmes are designed for long-term surveillance of antimicrobial resistance in key pathogens of bloodstream and community-acquired respiratory infection in the UK and Ireland. This paper describes their meth... | 18,819,976 |
Non-susceptibility trends and serotype distributions among Streptococcus pneumoniae from community-acquired respiratory tract infections and from bacteraemias in the UK and Ireland, 1999 to 2007. | Pneumococcal disease is prevalent and is a cause of significant morbidity and mortality in the UK and Ireland. We describe the antimicrobial susceptibility and serotype distributions of Streptococcus pneumoniae causing bacteraemia and community-acquired pneumonia in these countries from 1999/2000 to 2006/7, predominant... | 18,819,983 |
Non-susceptibility trends among Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections in the UK and Ireland, 1999-2007. | To determine the antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis causing community-acquired respiratory tract infections in the UK and Ireland from 1999/2000 to 2006/07. Sentinel laboratories across the UK and Ireland contributed up to a fixed quota of isolates of defined organisms per ... | 18,819,984 |
Thymidine kinase 2 defects can cause multi-tissue mtDNA depletion syndrome. | Mitochondrial DNA depletion syndrome (MDS) is a severe recessively inherited disease of childhood. It manifests most often in infancy, is rapidly progressive and leads to early death. MDS is caused by an increasing number of nuclear genes leading to multisystemic or tissue-specific decrease in mitochondrial DNA (mtDNA)... | 18,819,985 |
Surgical correlation of preoperative MRI findings of trauma to tendons and ligaments of the foot and ankle. | The purpose of this study was to determine whether magnetic resonance imaging findings are accurate and can be confirmed surgically. Surgical correlation of preoperative magnetic resonance imaging findings of trauma to tendons and ligaments of the foot and ankle were retrospectively studied in 28 patients who had under... | 18,820,039 |
Mini-open technique for the achilles tenotomy in correction of idiopathic clubfoot: a report of 25 cases. | Achilles tenotomy is performed for the residual equinus deformity in the Ponseti method of clubfoot treatment. In the present article, we describe a mini-open Achilles tenotomy technique to prevent complications that could occur during tenotomy. This technique was performed on 15 patients (25 feet) during a 3-year peri... | 18,820,046 |
Cloning and characterization of alpha-methylacyl coenzyme A racemase from Gordonia polyisoprenivorans VH2. | The mcr gene of Gordonia polyisoprenivorans VH2 is not clustered with genes required for rubber degradation. Its disruption by insertion of a kanamycin resistance cassette impaired growth on methyl-branched isoprenoids but not on linear hydrocarbons. Intact mcr from this bacterium or from Nocardia farcinica IFM 10152 c... | 18,820,059 |
Relative importance of Ixodes ricinus and Ixodes trianguliceps as vectors for Anaplasma phagocytophilum and Babesia microti in field vole (Microtus agrestis) populations. | The importance of Ixodes ricinus in the transmission of tick-borne pathogens is well recognized in the United Kingdom and across Europe. However, the role of coexisting Ixodes species, such as the widely distributed species Ixodes trianguliceps, as alternative vectors for these pathogens has received little attention. ... | 18,820,068 |
KMP-11, a basal body and flagellar protein, is required for cell division in Trypanosoma brucei. | Kinetoplastid membrane protein 11 (KMP-11) has been identified as a flagellar protein and is conserved among kinetoplastid parasites, but its potential function remains unknown. In a recent study, we identified KMP-11 as a microtubule-bound protein localizing to the flagellum as well as the basal body in both procyclic... | 18,820,079 |
Reading trajectories of children with language difficulties from preschool through fifth grade. | The current work examined which theory of reading development, the cumulative reading trajectory or the compensatory trajectory of development, most accurately represents the reading trajectories of children with language difficulties (LD) relative to their peers with typical language (TL) skills. Specifically, initial... | 18,820,089 |
Resource use and associated care effectiveness results for people with diabetes in managed care organizations. | To examine how resource use varies with care quality for managed care populations with diabetes. Data from 31 commercial health plans (23 health maintenance organizations and 8 preferred provider organizations) were analyzed. Resource use was calculated using medical and pharmacy claims and enrollment data for members ... | 18,820,141 |
The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. | Cytolytic enzymes (CEs) are critical mediators of anti-viral and -tumor immunity; however, as a number of molecules belong to this enzyme family, our understanding of CEs remains limited. Specifically, it remains unclear what combinations of granzymes and perforin (Perf) are expressed by various immune cells and how CE... | 18,820,174 |
A common RET variant is associated with reduced newborn kidney size and function. | Congenital nephron number varies five-fold among normal humans, and individuals at the lower end of this range may have an increased lifetime risk for essential hypertension or renal insufficiency; however, the mechanisms that determine nephron number are unknown. This study tested the hypothesis that common hypomorphi... | 18,820,179 |
Pyomyositis mimicking leptospirosis: two cases in a Brazilian tertiary care hospital in a non-tropical area. | Pyomyositis is a subacute, deep suppurative bacterial infection of skeletal muscle not arising from contiguous infection. It is presumably haematogenous in origin, and characterized by muscle pain and swelling. We report on two patients who presented with pyomyositis in a tertiary care hospital in temperate region loca... | 18,820,206 |
Primary amoebic meningoencephalitis: a new case from Venezuela. | Primary amoebic meningoencephalitis (PAM) is not often seen. To date, less than 300 cases have been communicated to the medical literature since the disease was first discovered in 1965. Six of these reports originated in Venezuela. The authors describe a new spontaneous case of PAM in a 33-year-old previously healthy ... | 18,820,207 |
Conformation and free energy analyses of the complex of calcium-bound calmodulin and the Fas death domain. | Previous studies have demonstrated a calcium-dependent interaction of calmodulin (CaM) and Fas that is regulated during Fas-induced apoptosis in several cell lines, including cholangiocarcinoma, Jurkat cells, and osteoclasts. The binding of CaM and Fas has been identified on residues 231-254 of Fas; the V254N point mut... | 18,820,240 |
Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells. | Here, we report on the discovery of a locus in the human genome, which evolved by gene duplication followed by an internal DNA inversion. This locus exhibits high sequence similarity to the gene for the inducible isoform of NOS protein (NOS2A) and is transcribed into a noncoding RNA containing a region of significant a... | 18,820,242 |
Pre-incisional epidural magnesium provides pre-emptive and preventive analgesia in patients undergoing abdominal hysterectomy. | This prospective, randomized, double-blind study was designed to evaluate the preemptive and preventive analgesic efficacy of adding magnesium to a multimodal regimen of patient-controlled epidural analgesia (PCEA) in patients undergoing abdominal hysterectomy. Ninety patients were randomly assigned to one of the three... | 18,820,247 |
TSG-6 transfers proteins between glycosaminoglycans via a Ser28-mediated covalent catalytic mechanism. | Studies of the interaction between Bikunin proteins, tumor necrosis factor-stimulated gene-6 protein (TSG-6), and glycosaminoglycans have revealed a unique catalytic activity where TSG-6/heavy chain 2 transfer heavy chain subunits between glycosaminoglycan chains. The activity is mediated by TSG-6/heavy chain 2 and inv... | 18,820,257 |
Rosuvastatin protects against podocyte apoptosis in vitro. | Clinical studies suggest that statins reduce proteinuria and slow the decline in kidney function in chronic kidney disease. Given a rich literature identifying podocyte apoptosis as an early step in the pathophysiological progression to proteinuria and glomerulosclerosis, we hypothesized that rosuvastatin protects podo... | 18,820,279 |
Efficacy and safety of sevelamer hydrochloride and calcium acetate in patients on peritoneal dialysis. | Inadequate phosphorus control is associated with increased morbidity and mortality in patients with CKD stage 5. Although phosphate binders are often used in patients on peritoneal dialysis (PD), no large randomized controlled studies evaluating their use solely in this population have previously been reported. In this... | 18,820,280 |
Human SWI/SNF directs sequence-specific chromatin changes on promoter polynucleosomes. | Studies in humans and other species have revealed that a surprisingly large fraction of nucleosomes adopt specific positions on promoters, and that these positions appear to be determined by nucleosome positioning DNA sequences (NPSs). Recent studies by our lab, using minicircles containing only one nucleosome, indicat... | 18,820,294 |
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