title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Evaluation of cis-regulatory function in zebrafish. | As increasing numbers of vertebrate genomes are sequenced, comparative genomics offers tremendous promise to unveil mechanisms of transcriptional gene regulation on a large scale. However, the challenge of analysing immense amounts of sequence data and relating primary sequence to function is daunting. Several teleost ... | 18,820,318 |
Sarcina-like bacteria associated with bloat in young lambs and calves. | Sarcina species are fastidious Gram-positive anaerobic bacteria that occur in cubical packets of eight or more cells. In 2006 to 2007, they were associated with cases of acute abomasal bloat in young lambs and calves. Two incidents were in lambs aged three to six weeks that were found dead, with one or two cases in eac... | 18,820,327 |
Using music in leisure to enhance social relationships with patients with complex disabilities. | Acquired and complex disabilities stemming from severe brain damage and neurological illness usually affect communication, cognitive, physical or sensory abilities in any combination. Improved understanding of the care needs of people with complex disabilities has addressed many functional aspects of care. However, rel... | 18,820,394 |
Tailoring leisure to suit a wider audience through creative event planning with a multi-sensory approach. | Caregiving for long-term conditions is increasingly focused on holistic "person centred" care [9,34], with leisure and recreation providing an important and essential part of maintaining quality of life. This article documents examples of large leisure events and creative projects. These were adapted for, and considere... | 18,820,400 |
Axon regeneration after spinal cord injury: insight from genetically modified mouse models. | The use of genetically modified mice to study axon regeneration after spinal cord injury has served as a useful in vivo model for both loss-of-function and gain-of-function analysis of candidate proteins. This review discusses the impact of genetically modified mice on axon regeneration after spinal cord injury in the ... | 18,820,409 |
History of ergonomics and occupational therapy. | Ergonomics is commonly known as "the scientific study of human work" [14, p. 3] and "the application of scientific information concerning human beings to the design of objects, systems, and environments" (p. 4). The American Occupational Therapy Association defines occupational therapy as "skilled treatment that helps ... | 18,820,415 |
New advances in stem cell biology: A perspective from gametogenesis. | Regeneration of adult tissues relies on a small population of adult stem cells located in a specialized microenvironment. The adult stem cells divide continuously to produce new stem cells, as well as differentiated daughter cells to replenish lost cells due to damage or aging. The molecular mechanisms controlling thei... | 18,820,451 |
The design and implementation of a multidisciplinary global health residency track at the Mount Sinai School of Medicine. | The Mount Sinai Global Health Center established a new multidisciplinary Global Health Residency Track (GHRT) in 2006. The goal of the GHRT is to provide participants with a foundation in global health issues and population-based health care, a chance to develop basic research and public health skills in the field, and... | 18,820,521 |
Antivirals and influenza: frequency of resistance. | Antivirals are effective in prophylaxis and therapy for influenza and are likely to be active against a new pandemic variant. They can be divided into the M2 inhibitors, adamantane and rimantadine, and the neuraminidase inhibitors (NAIs), zanamivir and oseltamivir. The former are limited in activity to type A viruses, ... | 18,820,569 |
Mitochondrial tRNAThr G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families. | To investigate the role of mitochondrial modifiers in the development of deafness associated with 12S rRNA A1555G mutation. Four Chinese families with nonsyndromic and aminoglycoside-induced deafness were studied by clinical and genetic evaluation, molecular and biochemical analyses of mitochondrial DNA (mtDNA). These ... | 18,820,594 |
Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. | Gap junctions (GJs) have been demonstrated to communicate cell death signals from apoptotic to healthy cells, thereby spatially extending apoptosis. Before being incorporated into GJs, hemichannels (hemi-GJs) are normally closed but recent evidence suggests that they can be opened by various messengers and conditions, ... | 18,820,645 |
Case-control study of subconjunctival triamcinolone acetonide injection vs intravenous methylprednisolone pulse in the treatment of endothelial corneal allograft rejection. | To assess the safety and effectiveness of treating corneal endothelial rejection with a subconjunctival injection of 20 mg triamcinolone acetonide in combination with topical application of 1% prednisolone acetate, as compared to treatment with an intravenous pulse of 500 mg methylprednisolone in combination with topic... | 18,820,657 |
Primary retroperitoneal myxoid/round cell liposarcoma is a nonexisting disease: an immunohistochemical and molecular biological analysis. | Almost all primary retroperitoneal liposarcomas can be classified as well-/dedifferentiated liposarcoma. Rarely, however, primary retroperitoneal liposarcoma is classified as myxoid/round cell liposarcoma, based on the presence of myxoid areas and vascular crow's feet pattern, which has resulted in a debate on the clas... | 18,820,664 |
Digestive histopathological presentation of IPEX syndrome. | Immunodysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX) syndrome is a well recognized and particularly severe form of autoimmune enteropathy. It has an X-linked recessive transmission, and is caused by mutations in the FOXP3 gene. We studied the intestinal morphological changes characteriz... | 18,820,676 |
Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. | Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteomi... | 18,820,680 |
Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. | Succinate acts as an extracellular mediator signaling through the G protein-coupled receptor GPR91. Here we show that dendritic cells had high expression of GPR91. In these cells, succinate triggered intracellular calcium mobilization, induced migratory responses and acted in synergy with Toll-like receptor ligands for... | 18,820,681 |
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. | T helper type 2 (T(H)2) cells are essential for humoral immunity and host defense. Interleukin 4 (IL-4) drives T(H)2 differentiation and IL-2 augments the accessibility of Il4 chromatin. Here we demonstrate that IL-2, by inducing binding of STAT5 to the Il4ra locus, which encodes IL-4 receptor alpha-chain (IL-4Ralpha),... | 18,820,682 |
Forebrain steroid levels fluctuate rapidly during social interactions. | Neurosteroids are powerful modulators of brain function and behavior, yet their dynamics in the brain have remained elusive. Using in vivo microdialysis in male zebra finches, we found that local estradiol levels increased rapidly in the forebrain during social interactions with females. Furthermore, when males were ex... | 18,820,691 |
Origin of correlated activity between parasol retinal ganglion cells. | Cells throughout the CNS have synchronous activity patterns; that is, a cell's probability of generating an action potential depends both on its firing rate and on the occurrence of action potentials in surrounding cells. The mechanisms producing synchronous or correlated activity are poorly understood despite its prev... | 18,820,692 |
Mirror-image representation of action in the anterior parietal cortex. | Mimicking hand actions made by someone facing us (that is, allocentric viewpoint) is typically performed with the opposite hand. Using functional magnetic resonance imaging (fMRI), we found a similar mirror-image representation of others' actions in the human anterior parietal cortex. Viewing egocentric-based actions e... | 18,820,694 |
Questioning the role of rebound firing in the cerebellum. | A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing und... | 18,820,695 |
Control of rice grain-filling and yield by a gene with a potential signature of domestication. | Grain-filling, an important trait that contributes greatly to grain weight, is regulated by quantitative trait loci and is associated with crop domestication syndrome. However, the genes and underlying molecular mechanisms controlling crop grain-filling remain elusive. Here we report the isolation and functional analys... | 18,820,698 |
Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. | Osteoarthritis (OA) is a progressively degenerative joint condition that is influenced by various metabolic and structural factors. The canonical Wnt-frizzled-beta-catenin pathway has been implicated in the pathogenesis of OA. Products of the Wnt, frizzled, secreted frizzled-related protein (sFRP), Dickkopf and LDL-rec... | 18,820,702 |
Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium. | Mesenchymal stem cells have been shown to mediate immunomodulatory effects. They have been used in patients with steroid-refractory acute GVHD (aGVHD), but their relevance as a therapeutic agent targeting aGVHD has still to be defined. In this case series, we report 13 patients with steroid-refractory aGVHD who receive... | 18,820,709 |
GVHD after chemotherapy conditioning in allogeneic transplanted mice. | GVHD is a major complication in allogeneic SCT. Available GVHD models are mainly based on radiotherapy-conditioning and/or immune deficient mice. GVHD models based on chemotherapy-based regimens remain poorly studied, despite 50% of all transplantations being chemotherapy based. Our aim was to develop a GVHD model usin... | 18,820,712 |
Arp2/3 branched actin network mediates filopodia-like bundles formation in vitro. | During cellular migration, regulated actin assembly takes place at the cell leading edge, with continuous disassembly deeper in the cell interior. Actin polymerization at the plasma membrane results in the extension of cellular protrusions in the form of lamellipodia and filopodia. To understand how cells regulate the ... | 18,820,726 |
Anti-plasmodium activity of angiotensin II and related synthetic peptides. | Plasmodium species are the causative agents of malaria, the most devastating insect-borne parasite of human populations. Finding and developing new drugs for malaria treatment and prevention is the goal of much research. Angiotensins I and II (ang I and ang II) and six synthetic related peptides designated Vaniceres 1-... | 18,820,728 |
Hyaluronidase of bloodsucking insects and its enhancing effect on leishmania infection in mice. | Salivary hyaluronidases have been described in a few bloodsucking arthropods. However, very little is known about the presence of this enzyme in various bloodsucking insects and no data are available on its effect on transmitted microorganisms. Here, we studied hyaluronidase activity in thirteen bloodsucking insects be... | 18,820,742 |
Changes in types of muscle fibers induced by transcutaneous electrical stimulation of the diaphragm of rats. | The objective of the present study was to assess the effect of transcutaneous electrical diaphragmatic stimulation (TEDS) on different types of diaphragm muscle fibers. Male Wistar rats (8-12 weeks old) were divided into 2 experimental groups (N = 8 in each group): 1) control, 2) animals submitted to TEDS [frequency = ... | 18,820,771 |
Training-related changes in the R-R interval at the onset of passive movements in humans. | The aim of the present study was to determine whether training-related alterations in muscle mechanoreflex activation affect cardiac vagal withdrawal at the onset of exercise. Eighteen male volunteers divided into 9 controls (26 +/- 1.9 years) and 9 racket players (25 +/- 1.9 years) performed 10 s of voluntary and pass... | 18,820,774 |
The use and midium-term evaluation of decellularized allograft cusp in the surgical treatment of the tetralogy of fallot. | To describe the technique of implantation and to show the echocardiographic follow-up of the decellularized cusps allografts used in patients with tetralogy of fallot. Fifteen patients underwent this implantation between March 2005 and August 2007 and they were clinically followed-up. An echocardiogram was performed to... | 18,820,782 |
Heparin quality control in the Brazilian market: implications in the cardiovascular surgery. | The change in the heparin solution trade mark in Brazil that had been commonly used in cardiac surgery has shown increased number in the coagulopathy, re-exploration and other side effects in our Institution and others. All four different heparin solutions available in the Brazilian market were studied in the Connectiv... | 18,820,778 |
High-frequency ultrasonic waves cause endothelial dysfunction on canine epicardial coronary arteries. | Application of ultrasound energy by an endarterectomy probe can facilitate the removal of atheromatous plaque, but the effect of this procedure on surrounding vessel structure and function is still a matter of experimental investigations. To determine whether ultrasound energy impairs the production of nitric oxide or ... | 18,820,781 |
Alternate HMQC experiments for recording HN and HC-correlation spectra in proteins at high throughput. | Alternate implementations of the SOFAST-HMQC experiment are described. In these alternate SOFAST-HMQC experiments (ALSOFAST-HMQC) excitation of the magnetization of interest is achieved by non-selective rf pulses while preserving the equilibrium polarization of passive spins. This alternate excitation scheme also allow... | 18,820,839 |
Incidence and predictability of amiodarone-induced thyrotoxicosis and hypothyroidism. | To determine the incidence and predictability of amiodarone-induced thyrotoxicosis (AIT) and hypothyroidism (AIH) in patients with cardiomyopathy. A total of 72 patients (mean age 69 +/- 11 years) living in an area previously endemic for thyroid disease but with currently sufficient iodine intake were enrolled in this ... | 18,820,854 |
Evaluation of pain experienced during breast ductal endoscopy. | Ductal endoscopy is valuable for the differential diagnosis of bloody nipple discharge; however, the pain associated with this procedure has not been evaluated. This study aims to assess the pain experienced by patients during ductal endoscopy. We studied a consecutive series of women who underwent ductal endoscopy, to... | 18,820,862 |
Clinical spectrum of internal hernia: a surgical emergency. | To define the indicators of bowel ischemia caused by congenital or acquired internal hernia, based on our 10-year experience in one center. We reviewed the medical records, imaging studies, and operative findings of 20 patients who underwent surgery for an internal hernia at our medical center between 1995 and 2005. Th... | 18,820,864 |
Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. | The role of the endocannabinoid system in haematopoietic cells is not completely understood. We investigated whether human erythroleukemia (HEL) cells were able to bind, metabolise and transport the main endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG). We also investigated whether AEA or 2-AG could... | 18,820,887 |
Does the SLC40A1 gene modify HFE-related haemochromatosis phenotypes? | Most hereditary haemochromatosis patients are homozygous for the C282Y mutation of the HFE gene. However, the phenotypic expression and clinical aggressiveness of the disease differs considerably from patient to patient. The main objective of this work was to study the role of variants in the SLC40A1 gene in the severi... | 18,820,912 |
[Classification of prosthetic loosening and determination of wear particles]. | Nowaday, loosening of orthopaedic implants implies important medical and socioeconomic problems. Implant loosening is caused by implant infections as well as aseptic loosening, due to particle disease and mechanical alterations. Clinically we divide the implant infection into early and late infections. Morphologically ... | 18,820,921 |
Autoimmune lymphoproliferative syndrome-like syndrome presented as lupus-like syndrome with mycobacterial joint infection evolved into the lymphoma. | The autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like syndrome are variable clinical conditions characterized by lymphoproliferative disease, autoimmune cytopenias and susceptibility to malignancy. A 59-year-old woman was admitted to the hospital for intractable generalized pain and stiffness with multiple s... | 18,820,932 |
MAGE-A1 expression is associated with good prognosis in neuroblastoma tumors. | Neuroblastoma is an embryonal tumor of neuroectodermal cells. Patients with metastatic neuroblastoma have a poor survival rate, which has led to numerous efforts to develop prognostic markers. Cancer/testis-specific antigens MAGE-A1 and MAGE-A3 genes were proposed as minimal residual disease (MRD) markers in neuroblast... | 18,820,946 |
Arthroscopic hemitrapeziectomy for first carpometacarpal arthritis: results at 7-year follow-up. | The purpose of this study was to determine the outcome of arthroscopic hemitrapeziectomy combined with thermal capsular plication and temporary K-wire fixation in patients with painful thumb basal joint due to either osteoarthritis or posttraumatic arthritis. There were 18 thumbs that were evaluated in this retrospecti... | 18,820,976 |
Single-blinded randomized trial of mechanical bowel preparation for colon surgery with primary intraperitoneal anastomosis. | We report the final analysis of a prospective single-blinded randomized trial designed to investigate whether omission of preoperative mechanical bowel preparation increases the rate of surgical-site infection and anastomotic failure after elective colon surgery with intraperitoneal anastomosis by a single surgeon. Pat... | 18,820,977 |
Carotid artery stenting: findings based on 8 years' experience. | Carotid artery stenting (CAS) may be an alternative to surgical endarterectomy not only in high-risk patients. Few data are available regarding the long-term clinical efficacy of CAS with the use of cerebral protection devices and the incidence of restenosis. Our experience demonstrates that if certain requirements are... | 18,820,992 |
Anion binding mediated precipitation of a peptibody. | Understand the underlying mechanism governing the salt-induced precipitation of a basic (pI = 8.8) protein, Peptibody A (PbA), in acidic solutions. The rate, extent, and reversibility of PbA precipitation was monitored over 4-weeks as a function of pH (3.7-5.0), salt concentration (0-400 mM), and ion identity using a s... | 18,820,999 |
Knowledge about breastfeeding among a group of primary care physicians and residents in Puerto Rico. | Physicians have an essential role in promoting, protecting, and supporting breastfeeding as the ideal method of infant feeding. They are in an important position to promote breastfeeding but report difficulty in advising mothers with lactation problems. The purpose of this study is to assess knowledge about breastfeedi... | 18,821,003 |
The 76-gene signature defines high-risk patients that benefit from adjuvant tamoxifen therapy. | To assess the benefit from adjuvant systemic tamoxifen therapy in breast cancer risk groups identified by the previously established prognostic 76-gene signature. In 300 lymph node-negative (LNN), estrogen receptor-positive (ER+) breast cancer patients (136 treated with adjuvant tamoxifen, 164 having received no system... | 18,821,012 |
Fabrication of protein chips based on 3-aminopropyltriethoxysilane as a monolayer. | Although 3-aminopropyltriethoxysilane (APTES) is widely adopted as a monolayer in biosensors, experimental silanization takes at least 1 h at high temperature. Therefore, the feasibility of the silanization with APTES in a short reaction time and at room temperature was investigated. The surface modification of glass s... | 18,821,014 |
Effect of actuation sequence on flow rates of peristaltic micropumps with PZT actuators. | Many biomedical applications require the administration of drugs at a precise and preferably programmable rate. The flow rate generated by the peristaltic micropumps used in such applications depends on the actuation sequence. Accordingly, the current study performs an analytical and experimental investigation to deter... | 18,821,016 |
Adrenal changes associated with adrenarche. | The mechanisms causing the rise in adrenal androgen production during the course of adrenarche remain to be defined. However, the increase in steroid release is clearly associated with a series of intra-adrenal changes in the expression of steroidogenic enzymes needed for dehydroepiandrosterone (DHEA) and dehydroepiand... | 18,821,019 |
Circulating fatty acids and prostate cancer risk in a nested case-control study: the Multiethnic Cohort. | Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting. We examined the association between erythrocyte membrane fatty acid composition and prostate cancer risk in a nested case-control study w... | 18,821,021 |
Monitoring of the physical parameters and evaluation of the chemical composition of river and groundwater in Calabar (Southeastern Nigeria). | A 12-month study was carried to assess the seasonal and tidal effects on the physical parameters of river and groundwater, which constitute the major potable water sources in Calabar (Nigeria). The study also included an evaluation of the chemical composition of the different water bodies and their relationship. The re... | 18,821,024 |
Production of Prnp-/- goats by gene targeting in adult fibroblasts. | Homozygous mice devoid of functional Prnp are resistant to scrapie and prion propagation, but heterozygous mice for Prnp disruption still suffer from prion disease and prion deposition. We have previously generated heterozygous cloned goats with one allele of Prnp functional disruption. To obtain goats with both allele... | 18,821,027 |
Suicide and alcohol-related mortality in Hungary in the last two decades. | Suicide and alcohol-related mortality are often linked to each other in recent times, especially in the unfavourable mortality trends detected in Russia. Recent study has aimed to investigate suicide and alcohol-related mortality in Hungary between 1986 and 2005. This paper is based on the concept of social anomie and ... | 18,821,056 |
Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States. | Mammographic breast density is an established marker of breast cancer risk, and is hormonally sensitive. Studies suggest that production of the daidzein metabolites equol and O-Desmethylangolensin (ODMA) may be associated with hormones and hormonally mediated factors, but few studies have assessed relationships between... | 18,821,061 |
Risk-adapted management for patients with clinical stage I non-seminomatous germ cell tumour of the testis. | Testis cancer is the most common cancer in young men and its incidence continues to rise. Even if prognosis is considered as good, a group with bad prognosis still remains. We aimed to evaluate whether two courses of chemotherapy after orchiectomy in patients with clinical stage I, non-seminomatous germ cell testicular... | 18,821,067 |
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. | Biomarkers of clinical response to rituximab (RTX) therapy and early predictors of outcome are still under investigation. We report a flow cytometric immunophenotyping analysis from peripheral blood leukocyte subpopulations of two patients with systemic lupus erythematosus (SLE) associated thrombocytopenia and one pati... | 18,821,073 |
Movement disorder emergencies. | Movement disorder emergencies include any movement disorder which evolves over hours to days, in which failure to appropriately diagnose and manage can result in patient morbidity or mortality. It is crucial that doctors recognize these emergencies with accuracy and speed by obtaining the proper history and by being fa... | 18,821,080 |
Integrating research into practice: a challenge for local authority occupational therapy. | The aim of this qualitative study was to identify and analyse the experiences of Swedish local health authority occupational therapists with regard to their participation in, and the implementation of, research. Data were collected from three focus-group interviews, with five different occupational therapists in each. ... | 18,821,136 |
Metabolic syndrome and multiple organ damage in essential hypertension. | We investigated the prevalence of the metabolic syndrome (MS) in hypertensive patients categorized according to the number of markers of organ damage (OD) in order to assess the value of a systematic search for cardiac and extra-cardiac OD in the MS setting. A total of 3119 untreated and treated essential hypertensives... | 18,821,143 |
Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites. | Trichloroethylene (TCE) is an industrial solvent and a widespread environmental contaminant. Induction of liver cancer in mice by TCE is thought to be mediated by two metabolites, dichloroacetate (DCA) and trichloroacetate (TCA), both of which are themselves mouse liver carcinogens. TCE, TCA, and DCA are relatively wea... | 18,821,149 |
Preparation and evaluation of fast-disintegrating effervescent tablets of glibenclamide. | Fast-dissolving effervescent tablets (FETs) were prepared by the modification of nonreactive liquid-based wet granulation technique. Effervescent systems are not stable in the presence of trace amount of moisture, and elimination or inactivation of free water is the key to stability apart from manufacturing in controll... | 18,821,151 |
Occupational therapy, professional development, and ethics. | The aim of this article is to reflect on and contribute to developing occupational therapy as a profession. The author proposes an ethical interpretation of health and helping professions in general and occupational therapy in particular. According to this ethical interpretation, the essential function and mission of c... | 18,821,177 |
Evidence-based research and practice in clinical neuropsychology. | While a definition for evidence-based clinical neuropsychological practice (EBCNP) has yet to emerge, it is likely to integrate the same core features as evidence-based medicine; namely, best research evidence, clinical expertise, and individual patient needs. Given the nascent stage of EBCNP, suggestions are made to a... | 18,821,179 |
Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults. | Impaired everyday function is a diagnostic criterion for dementia, and a determinant of healthcare utilization and caregiver burden. Although many previous studies have demonstrated a cross-sectional relationship between cognition (particularly executive functions and memory) and everyday function in older adults, very... | 18,821,181 |
Women's experiences of increasing subjective well-being in CFS/ME through leisure-based arts and crafts activities: a qualitative study. | To understand the meanings of art-making among a group of women living with the occupational constraints and stigma of CFS/ME. The study explored their initial motives for art-making, and then examined how art-making had subsequently influenced their subjective well-being. Ten women with CFS/ME were interviewed; three ... | 18,821,193 |
Threshold of pain in chronic magnetic field- (50 Hz, 17.9 microT) exposed rats: effect of sucrose ingestion. | Both magnetic field (MF) exposure and sucrose ingestion produce opioid mediated analgesia, independently. This article addresses the query whether or not sucrose ingestion potentiates the analgesia of MF exposure. The pain threshold, as reflected by withdrawal of tail (thresholds of tail flick, TF), vocalization during... | 18,821,201 |
Effects of extremely low-frequency-pulsed electromagnetic field on different-derived osteoblast-like cells. | The aim of this study is to investigate the effects of extremely low-frequency pulsed electromagnetic field (PEMF) on osteoblast-like cells. PEMF with a magnetic flux density of 1.55 mT at 48 Hz was employed to stimulate the MC3T3-E1 cell and the primary osteoblast cell derived from 2-day-old Sprague Dawley (SD) rat ca... | 18,821,205 |
A simple image analysis algorithm for evaluation of extended filaments length based on the enhanced digitized image. | An automated image analysis procedure was developed to determine extended filaments length and floc area to evaluate settling characteristics of activated sludge. Digitized image obtained by Gram staining granted the first step of algorithm, segmentation, to be extremely clear and simple. The image analysis work could ... | 18,821,233 |
Extraction of nonylphenol and nonylphenol ethoxylates from sewage sludge using the pressurized fluid extraction method and the supercritical fluid extraction method. | To establish endocrine disruptor (ED) monitoring and control methods for wastewater treatment plants, it is necessary to clarify the fate of EDs in each process of a sludge treatment system. However, the ED analysis method for sewage sludge containing large quantities of organic matters has not been established. So, a ... | 18,821,236 |
Chemical sludge conditioning in combination with different conventional and alternative dewatering devices: chamber filter press, decanter and Bucher press. | The Kemicond process for sludge conditioning consists of chemical treatment with sulphuric acid and hydrogen peroxide at a pH-value of approximately 4 followed by a dewatering unit. It is shown that chemical treatment can improve the dewaterability of ferruginous digested sludge. It is concluded that the Fenton process... | 18,821,238 |
Synthesis and immunosuppressive activity evaluation of substituted N-imidazolidin-2-ones and N-tetrahydropyrimidin-2(1H)-ones. | Seventeen compounds with either an imidazolin-2-one or a tetrahydropyrimidin-2(1H)-one scaffold were synthesized and evaluated for their immunosuppressive activity in a concanavallin A (ConA)-stimulated mouse splenocytes proliferation test. Three of these molecules exerted a significant activity at 90 microM. All the c... | 18,821,255 |
Pathological gambling, delusional parasitosis and adipsia as a post-haemorrhagic syndrome: a case report. | The authors describe the case of a 70-year-old male who developed a peculiar syndrome characterized by pathological gambling (PG), delusional parasitosis and adipsia with mild frontal symptoms. Onset of the syndrome followed a cerebral haematoma involving hypothalamic and bilateral ventromedial prefrontal areas. The po... | 18,821,269 |
Multiple parietal operculum subdivisions in humans: tactile activation maps. | We focused the present analysis on blood-oxygen-level-dependent responses evoked in four architectonic subdivisions of human posterior parietal operculum (PO) during two groups of tasks involving either vibrotactile stimulation or rubbing different surfaces against the right index finger pad. Activity localized in prev... | 18,821,280 |
Increased prevalence of erectile dysfunction (ED): results of the second epidemiological study on sexual activity and prevalence of ED in Thai males. | The aim of this study is to investigate changes in sexual activity and the prevalence of erectile dysfunction (ED) in Thai males. In addition, the treatment-seeking behaviour of Thai patients suffering from ED is also investigated. In a cross sectional study using a standardized questionnaire with a multi-stage stratif... | 18,821,288 |
Noninvasive cardiac imaging: implications for risk assessment in adolescents and young adults. | Noninvasive imaging of cardiovascular end organ injury has now been applied to adolescents and young adults to better understand the early natural history of chronic heart disease. Echocardiography, assessment of endothelial function, and subclinical atherosclerosis imaging using carotid intima-media thickness measures... | 18,821,334 |
Diagnosed eating disorders in the U.S. Military: a nine year review. | The objective of this study was to determine the incidence of three types of eating disorders (ED); anorexia nervosa (AN), bulimia nervosa (BN) and eating disorder not otherwise specified (EDNOS), diagnosed in the U.S. Military. Diagnosed cases of ED were obtained from the Defense Medical Epidemiology Database for all ... | 18,821,361 |
Water disinfection and hygiene behaviour in an urban slum in Kenya: impact on childhood diarrhoea and influence of beliefs. | In this research project, we studied factors that presumably affect the incidence of diarrhoea among young children in urban slums in developing countries: consumption of safe drinks, hygiene behaviour, cleanliness of household surroundings and the quality of raw water. Beliefs concerning the causes of diarrhoea were a... | 18,821,373 |
Characterization of cells expressing RNA polymerase II tagged with green fluorescent protein: effect of ionizing irradiation on RNA synthesis. | To isolate and to characterize cells expressing RNA polymerase II tagged with green fluorescent protein for analyses of the effects of ionizing radiation on transcription in living cells. We introduced an alpha-amanitin-resistant mutation into a vector encoding the largest subunit of RNA polymerase II tagged with green... | 18,821,392 |
Influence of zoo visitor presence on the behavior of captive Indian gaur (Bos gaurus gaurus) in a zoological park. | Visitors to zoos can be a source of potential disturbance and stress to some captive, nonhuman animals in the wild. To determine the influence of visitor presence on captive bison (Bos gaurus gaurus), the study analyzed the behavior of 4 individuals at the Arignar Anna Zoological Park, India. The study often observed t... | 18,821,404 |
High psychiatric symptom severity is a moderator of substance abuse treatment outcomes among women in single vs. mixed gender group treatment. | This exploratory study examined psychiatric symptom severity as a moderator of outcomes among women receiving either the Women's Recovery Group (WRG), a new manualized group treatment for substance use disorders combining single-gender group composition and women-focused content, or Group Drug Counseling (GDC), an empi... | 18,821,452 |
History of physical or sexual abuse and participation in 12-step self-help groups. | Although 12-step groups are an important resource for managing substance use problems, their efficacy for patients with a physical or sexual abuse history is unknown. In the present study, patients with a history of physical or sexual (n = 122) or no (n = 143) abuse were interviewed at entry to outpatient substance use... | 18,821,455 |
Advances in immunotherapy of castration-resistant prostate cancer: bisphosphonates, phosphoantigens and more. | Medical progress has prolonged life expectancy in patients with castration-resistant prostate cancer; however, the lack of effective therapies has fuelled an intensive search for novel modalities, including immunotherapy. Human gammadelta T-cells can be activated by endogenous pyrophosphates (phosphoantigens), or by ag... | 18,821,471 |
[Antiepileptic drugs - fast versus slow titration and discontinuation]. | The indication and management of an appropriate therapy with antiepileptic drugs (AEDs) requires an individualized diagnostic evaluation considering the clinical situation. Based on the current scientific data the therapeutic options and special aspects of the available AEDs are discussed with emphasis on the possibili... | 18,821,523 |
Origin of diastereocontrol in the oxy-Michael reactions of delta-lactol anions: a computational and experimental study. | The diastereoselectivity in the alkylation and Michael addition of "naked" 6-substituted delta-lactolates has been studied by density functional (B3LYP) calculations with ab initio (MP2) energy refinements. The resulting proposed model for the origins of stereocontrol in this reaction has been tested by experiment. The... | 18,821,546 |
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. | Attention deficit hyperactivity disorder (ADHD) is a complex condition with environmental and genetic etiologies. Up to this point, research has identified genetic associations with candidate genes from known biological pathways. In order to identify novel ADHD susceptibility genes, 600,000 SNPs were genotyped in 958 A... | 18,821,565 |
Comparison of rehabilitation results in deaf patients with and without genetically related hearing loss. | The introduction of prognostic tools to evaluate rehabilitation progress in cochlear implant patients (CI patients) is of great importance. The authors attempted to verify whether the identified 35delG mutation in the GJB2 gene can serve as a valuable indicator for rehabilitation progress of CI patients. A group of 51 ... | 18,821,568 |
Isolation and characterization of porcine adult muscle-derived progenitor cells. | Here, we report the isolation of progenitor cells from pig skeletal muscle tissue fragments. Muscle progenitor cells were stimulated to migrate from protease-digested tissue fragments and cultured in the presence of 5 ng/ml basic fibroblast growth factor. The cells showed a sustained long-term expansion capacity (>1... | 18,821,573 |
A questionnaire based review of long-term follow-up programs for survivors of childhood cancer in Canada. | Major advances have been made in the treatment of childhood cancer; however, survivors of childhood cancer are at increased risk for morbidity and mortality. There is little literature regarding available long-term follow-up programs for survivors of childhood cancer. In March 2007, 16 surveys were sent to pediatric he... | 18,821,577 |
Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. | EphA7 is a member of Eph/ephrins family and play diverse roles in carcinogenesis. The aim of our study was to investigate functional and structural alterations of EphA7 in prostate cancer and determine if those findings correlate with the clinicopathologic features of prostate cancer. Forty-eight prostate carcinomas, 3... | 18,821,581 |
Dynamic perfusion MRI: capability for evaluation of disease severity and progression of pulmonary arterial hypertension in patients with connective tissue disease. | To prospectively evaluate the capability of dynamic perfusion MRI for assessment of disease severity and progression to pulmonary arterial hypertension (PAH) in connective tissue disease (CTD) patients. In all, 18 gender- and age-matched CTD patients without and with PAH and nine healthy volunteers underwent dynamic pe... | 18,821,609 |
Reproducible MRI measurement of adipose tissue volumes in genetic and dietary rodent obesity models. | To develop ratio MRI [lipid/(lipid+water)] methods for assessing lipid depots and compare measurement variability with biological differences among lean controls (spontaneously hypertensive rats [SHRs]), dietary obese rats (SHR-DOs), and genetic/dietary obese rats (SHROBs). Images with and without chemical shift-select... | 18,821,617 |
Magnetic resonance imaging and spectroscopy for monitoring liver steatosis. | To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content. Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in-phase/out-of-phase (IP/OP) and plus/minus fat saturation (+/-FS) techniques. The reproducibility of each MR... | 18,821,619 |
Evaluation of motion correction effect and image quality with the periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) (BLADE) and parallel imaging acquisition technique in the upper abdomen. | To evaluate motion correction effect and image quality in the upper abdomen with the periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) (BLADE) and parallel imaging acquisition technique. A total of 50 consecutive patients underwent abdominal MR imaging. Fat-saturated T2-weighted t... | 18,821,630 |
Signal features of the atherosclerotic plaque at 3.0 Tesla versus 1.5 Tesla: impact on automatic classification. | To investigate the impact of different field strengths on determining plaque composition with an automatic classifier. We applied a previously developed automatic classifier-the morphology enhanced probabilistic plaque segmentation (MEPPS) algorithm-to images from 20 subjects scanned at both 1.5 Tesla (T) and 3T. Avera... | 18,821,634 |
Biocatalytic polyester acrylation--process optimization and enzyme stability. | An OH-functional polyester has been acrylated via transesterification of ethyl acrylate, catalyzed by Candida antarctica lipase B (CalB) in two different preparations: Novozym 435 and immobilized on Accurel MP1000. The batch process resulted in incomplete acrylation as well as severe degradation of the polyester. A hig... | 18,821,636 |
An efficient and scalable process for helper-dependent adenoviral vector production using polyethylenimine-adenofection. | Safety requirements for adenoviral gene therapy protocols have led to the development of the third generation of vectors commonly called helper-dependent adenoviral vectors (HDVs). HDVs have demonstrated a high therapeutic potential; however, the poor efficiency and reliability of the actual production process hampers ... | 18,821,637 |
Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. | Osteoclast-associated receptor (OSCAR) is a newly identified osteoclast-specific receptor and is of key importance in the process of osteoclast costimulation. This study was undertaken to define the role of costimulation in osteoclast differentiation during inflammatory arthritis. OSCAR expression was assessed in the s... | 18,821,671 |
Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis. | To investigate the expression of vascular endothelial growth factor (VEGF) in muscle biopsy specimens and serum from patients with polymyositis and patients with dermatomyositis compared with that in healthy control subjects. Muscle biopsy specimens from 33 patients with polymyositis or dermatomyositis and 15 healthy c... | 18,821,695 |
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