title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis. | To assess the effects of epigallocatechin-3-gallate (EGCG) on oncostatin M (OSM)-induced CCL2 synthesis and the associated signaling pathways in human osteoblastic cells. The therapeutic effect of EGCG on collagen-induced arthritis (CIA) in rats was also studied. CCL2 and c-Fos messenger RNA expression was analyzed by ... | 18,821,707 |
Nimesulide associated fulminant hepatic failure. | It is controversial whether the non-steroidal inflammatory drug nimesulide is associated with severe hepatotoxicity. Our objective was to determine whether nimesulide is associated with fulminant hepatic failure. Retrospective cohort study in the Irish national liver transplant unit. All patients who received a liver t... | 18,821,716 |
Characteristic negative ion fragmentations of deprotonated peptides containing post-translational modifications: mono-phosphorylated Ser, Thr and Tyr. A joint experimental and theoretical study. | Peptides and proteins may contain post-translationally modified phosphorylated amino acid residues, in particular phosphorylated serine (pSer), threonine (pThr) and tyrosine (pTyr). Following earlier work by Lehmann et al., the [M-H]- anions of peptides containing pSer and pThr functionality show loss of the elements o... | 18,821,730 |
Characteristics and comparison of different radiofrequency-only multipole cooling cells. | Various multipole cooling cells are widely used in mass spectrometry for their outstanding performance with regard to transmission and cooling effects. Among these, radiofrequency (RF)-only quadrupoles, hexapoles, and octopoles are routinely used in practical instrumentation. A study of their performance has been carri... | 18,821,731 |
Interpretation of the electronic spectra of four disilanes. | Time-dependent density functional theory (TD-DFT/B3LYP(AC)/cc-pVTZ/cc-pVTZ/6-311G//MP2/cc-pVTZ/cc-pVTZ/6-31G**) has been used to compute vertical excitation energies and oscillator strengths of the six low-lying excited states of four peralkylated disilanes, hexamethyldisilane (1), hexa-tert-butyldisilane (2), 1,6-disi... | 18,821,735 |
Realization of SOMO-HOMO level conversion for a TEMPO-dithiolate ligand by coordination to platinum(II). | We developed a TEMPO-bound dithiolate ligand (= tempodt) and its Pt(diimine)(dithiolate) complex to realize a unique electronic structure with the potential for unprecedented functionalities. The physical properties and electronic structures of tempodt, (tempodt)Pt, and their related compounds were investigated by cycl... | 18,821,762 |
Highly diastereoselective addition of lithio vinyl sulfoxides to N-sulfinimines: an entry to enantiopure 3-sulfinyl-2,5-cis-dihydropyrroles. | The addition of enantiopure alpha-metalated vinyl and dienyl sulfoxides to enantiomerically pure N-sulfinimines takes place with high diastereoselectivity primarily directed by the N-sulfinimine sulfur. The resulting allylic amines have been further transformed into highly functionalized 3-sulfinyl and 3-sulfonyl 2,5- ... | 18,821,766 |
Total synthesis of (+)-lepadin F. | An enantioselective total synthesis of (+)-lepadin F is described. The synthetic sequence features an intermolecular aza-[3 + 3] annulation, homologation of a vinylogous amide via Eschenmoser's episulfide contraction, and a highly stereoselective hydrogenation essential for achieving the 1,3-anti relative stereochemist... | 18,821,767 |
Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA. | N'-Nitrosonornicotine (NNN) is the most prevalent of the carcinogenic tobacco-specific nitrosamines found in all tobacco products. Previous studies have demonstrated that cytochrome P450-mediated 5'-hydroxylation of NNN is a major metabolic pathway leading to mutagenic products, but to date, DNA adducts formed by this ... | 18,821,782 |
Ag4V2O6F2 (SVOF): a high silver density phase and potential new cathode material for implantable cardioverter defibrillators. | The electrochemical reactivity of the cathode material Ag 4V 2O 6F 2 (SVOF) versus lithium, with a particular emphasis on the lithium insertion mechanism, was studied by means of the complementary techniques in situ X-ray diffraction, electron paramagnetic resonance, and high-resolution transmisssion electron microscop... | 18,821,813 |
Status of trivalent copper and charge-transfer excitons in high-TC cuprates. | A chemical bonding approach based on tight-binding cluster and band calculations, taking into account on-site Coulomb repulsion (Hubbard U parameter) to differentiate doubly and singly occupied states, was applied to high- T C superconducting cuprates and related compounds. This work provides rational insight and expla... | 18,821,815 |
Structures and properties of functional metal selenites and tellurites. | Metal selenites and tellurites are a class of very important compounds. In this paper, the structures and properties of metal selenites or tellurites combining with transition-metal (TM) ions with the d (0) electronic configuration or tetrahedral MO 4 building blocks of post-transition main-group elements were reviewed... | 18,821,816 |
A-site-ordered perovskites with intriguing physical properties. | Recent findings on intriguing physical properties of new A-site-ordered perovskite structure oxides are reviewed. High-pressure and high-temperature conditions stabilize the square-coordinated Jahn-Teller Cu (2+) ions in the original 12-fold-coordinated positions of the perovskite structure. The special-ordered arrange... | 18,821,822 |
Using mechanistic models to understand synchrony in forest insect populations: the North American gypsy moth as a case study. | In many forest insects, subpopulations fluctuate concurrently across large geographical areas, a phenomenon known as population synchrony. Because of the large spatial scales involved, empirical tests to identify the causes of synchrony are often impractical. Simple models are, therefore, a useful aid to understanding,... | 18,821,838 |
Optimization of amniotic membrane (AM) denuding for tissue engineering. | Amniotic membrane (AM) has gained increasing popularity as a useful carrier for ex vivo-expanded cells for tissue engineering, particularly in ocular surface reconstruction. However, current methods employed for denuding AM are highly variable, and the consequent effects on the structural and molecular composition of t... | 18,821,842 |
Hyperbaric oxygen activates discoidin domain receptor 2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix metalloproteinase 2. | DDR2 (discoidin domain receptor 2) regulates collagen turnover mediated by SMCs (smooth muscle cells) in atherosclerosis. HBO (hyperbaric oxygen) has been used in medical practice; however, the molecular mechanism of the beneficial effects of HBO is poorly understood. Furthermore, the effect of HBO on DDR2 has not been... | 18,821,853 |
Redox control of renal function and hypertension. | Loss of redox homeostasis and formation of excessive free radicals play an important role in the pathogenesis of kidney disease and hypertension. Free radicals such as reactive oxygen species (ROS) are necessary in physiologic processes. However, loss of redox homeostasis contributes to proinflammatory and profibrotic ... | 18,821,850 |
Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department. | The hypothesis was that the tandem measurement of D-dimer and myeloperoxidase (MPO) or C-reactive protein (CRP) could significantly decrease unnecessary pulmonary vascular imaging in emergency department (ED) patients evaluated for pulmonary embolism (PE) compared to D-dimer alone. The authors measured the sequential c... | 18,821,859 |
Genetic and environmental contributions to the diversity of substances used in adolescent twins: a longitudinal study of age and sex effects. | To determine how genetic and environmental contributions affecting the number of psychoactive substances used varies with age and gender over the course of adolescence. Estimates of genetic, shared environmental and non-shared environmental contributions to total variance in diversity of substances used at ages 11, 14 ... | 18,821,880 |
Nipple-sparing mastectomy: lessons from ex vivo procedures. | Moderate size series have reported successful nipple-sparing mastectomy using a variety of surgical techniques. This study aimed to understand which aspects of these techniques are safe, necessary, and successful. Eight skin-sacrificing mastectomy specimens were used as ex vivo models of nipple-sparing mastectomy. Afte... | 18,821,932 |
Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients. | The IL-15 triggering effect of gliadin is not exclusive to coeliac disease (CD) patients, whereas the secondary response is CD specific. We have studied the expression of the IL-15 receptor, and the IL-15 response upon stimulation, in non-CD and CD patients, and the possible existence of a lower immunological threshold... | 18,821,940 |
Regulatory T cells in human immunodeficiency virus-infected patients are elevated and independent of immunological and virological status, as well as initiation of highly active anti-retroviral therapy. | Infection with human immunodeficiency virus (HIV) causes a dysregulation of the immune system. This is caused by HIV-specific as well as non-specific mechanisms and has not been explained fully. In particular, knowledge is lacking about the potential role of host-mediated immunosuppressive mechanisms. During recent yea... | 18,821,942 |
pH changes after manual or ultrasonic instrumentation and smear layer removal with EDTA or ultrasonic. | The purpose of the present study was to evaluate the influence of instrumentation techniques associated with the smear layer removal, in the pH changes of the root surface. Thirty mandibular humans premolars were divided into three groups: Group I - instrumentation by Ohio technique and final cleaning with EDTA (3 minu... | 18,821,959 |
An unusual lateral luxation of an upper incisor owing to long-term boxing without protection. | This case report describes a lateral luxation of an upper incisor in a 19-year-old non-professional boxer. The tooth displacement gradually worsened over several months because the boxer received repeated blows to the head without using a mouthguard. Being a chronic dental trauma, rather than an acute lateral luxation,... | 18,821,961 |
Partial replacement of the dentin-pulp complex by periodontal supporting tissues in a traumatically intruded primary maxillary incisor. | This paper describes a case of a 9-year-old patient who presented a completely intruded primary maxillary incisor because of a traumatic injury sustained at the age of 3 years. After tooth extraction, histological analysis revealed that the dentin-pulp complex was partially replaced by cementum, periodontal ligament an... | 18,821,962 |
External multiple invasive cervical resorption with subsequent arrest of the resorption. | A rare, the uncommon, case of multiple invasive cervical resorption (MICR) with subsequent arrest of the resorption involving eight teeth of the mandible (tooth 46 to tooth 32) is presented. This case is noteworthy because of the characteristics of its clinical evolution. There have only been a few cases in the literat... | 18,821,963 |
Taste deficits after middle ear surgery for otosclerosis: taste somatosensory interactions. | The aim of this study was to evaluate the postoperative consequences of chorda tympani reclining during middle ear surgery for otosclerosis. Electrogustometric taste thresholds were measured at 11 loci on the tongue and the soft palate in 14 patients before surgery, and 8 d, 1 month and (in some cases) 6 months after s... | 18,821,980 |
Mutations in the EDA gene are responsible for X-linked hypohidrotic ectodermal dysplasia and hypodontia in Chinese kindreds. | X-linked hypohidrotic ectodermal dysplasia (XLHED, OMIM 305100) is a rare congenital disorder that results in the defective development of teeth, hair, nails, and eccrine sweat glands. Previous studies found that mutations in the ectodysplasin A (EDA) gene are associated with XLHED. In the present study, we investigate... | 18,821,982 |
Myelin basic protein is temporospatially expressed in developing rat molars. | Tooth development occurs through a complex and intricate set of gene-expression cascades. Although its early events have been examined extensively, there are fewer reports on the late events, such as dental hard-tissue formation. This study searched for genes involved in the late stages of tooth development. Differenti... | 18,821,983 |
Reducing psychotropic medications in elderly rehabilitation inpatients with a fall-related admission: how often is it happening? | To assess the frequency of psychotropic medication withdrawal in an inpatient geriatric rehabilitation population with a fall-related admission diagnosis. A retrospective medical record audit. The medical records department randomly selected 100 patients admitted between October 2006 and April 2007 to the geriatric reh... | 18,821,996 |
Simultaneous determination of 21 preservatives in cosmetics by ultra performance liquid chromatography. | An ultra performance liquid chromatography (UPLC) method has been developed for the simultaneous determination of 21 preservatives: 2-methyl-4-isothiazoline-3-ketone, bronopol, 5-chloro-2-methyl-4-isothiazoline-3-ketone, benzyl alcohol, 2-phenoxyethanol, methyl-p-hydroxy benzoate, ethyl-p-hydroxy benzoate, methyl benzo... | 18,822,043 |
Comparison of apomorphine and levodopa infusions in four patients with Parkinson's disease with symptom fluctuations. | Motor fluctuations in patients with advanced Parkinson's disease may be successfully treated with subcutaneous apomorphine infusion or intraduodenal levodopa/carbidopa infusion. No comparative trials of these two alternatives were performed. We present a subanalysis from a randomized crossover clinical trial where levo... | 18,822,087 |
A GYS1 gene mutation is highly associated with polysaccharide storage myopathy in Cob Normand draught horses. | Glycogen storage diseases or glycogenoses are inherited diseases caused by abnormalities of enzymes that regulate the synthesis or degradation of glycogen. Deleterious mutations in many genes of the glyco(geno)lytic or the glycogenesis pathways can potentially cause a glycogenosis, and currently mutations in fourteen d... | 18,822,097 |
Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice. | Trypanosoma brucei subspecies invade the brain parenchyma at late stages of human and experimental rodent infections. In this study, we compared the outcome of infection with T. b. brucei in MHC-matched (H-2b) C57BL/6 (B6) and 129Sv/Ev (Sv-129). Sv-129 showed higher parasitaemia and lower specific IgM (but not IgG) ant... | 18,822,108 |
Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes. | The tissue specificity of gene expression has been linked to a number of significant outcomes including level of expression, and differential rates of polymorphism, evolution and disease association. Recent studies have also shown the importance of exploring differential gene connectivity and sequence conservation in t... | 18,822,114 |
Ultrasound evaluation of the abductor hallucis muscle: Reliability study. | The Abductor hallucis muscle (AbdH) plays an integral role during gait and is often affected in pathological foot conditions. The aim of this study was to evaluate the within and between-session intra-tester reliability using diagnostic ultrasound of the dorso-plantar thickness, medio-lateral width and cross-sectional ... | 18,822,116 |
Menopause, postmenopausal hormone use and serum uric acid levels in US women--the Third National Health and Nutrition Examination Survey. | Despite the substantial prevalence of gout in the ageing female population, female hormonal influence has not been comprehensively examined. We evaluated and quantified the potential independent association between menopause, postmenopausal hormone use and serum uric acid levels in a nationally representative sample of... | 18,822,120 |
The KBG syndrome: Case report. | The KBG syndrome is a rare autosomal dominant condition, first described by Hermann et al. in 1975. Fundamental findings are: mild development delay, short stature, craniofacial dysmorphism and skeletal anomalies. A 32 years old woman, Caucasian race, weight 57 Kg, affected by KBG syndrome was sent to our clinics for p... | 18,822,138 |
Role of Smac/DIABLO in cancer progression. | Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. In the cytosol, Smac/DIABLO interac... | 18,822,137 |
Kikuchi-Fujimoto Disease: A case report and review of the literature. | Kikuchi-Fujimoto Disease is a rare benign, condition of necrotising histiocytic lymphadenitis. A case of a 55 year old gentleman is described here. He presented with fevers, weight loss and tender cervical lymph nodes. Kikuchi-Fujimoto disease was diagnosed after cervical lymph node biopsy. Symptomatic treatment was p... | 18,822,141 |
Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression profiles. | Contrary to the traditional biology approach, where the expression patterns of a handful of genes are studied at a time, microarray experiments enable biologists to study the expression patterns of many genes simultaneously from gene expression profile data and decipher the underlying hidden biological mechanism from t... | 18,822,150 |
Growing pains: contemporary knowledge and recommended practice. | Leg pain in children, described as growing pains, is a frequent clinical presentation seen by an array of health care professionals. Described since 1823, growing pains continues to puzzle practitioners, yet diagnostic criteria and evidence based treatment is available. The medical literature has been searched exhausti... | 18,822,152 |
Designing a tobacco counter-marketing campaign for African American youth. | The objectives of this qualitative study were to: a) identify common marketing themes and tactics used by the tobacco industry to entice African Americans (AA's) and youth to initiate and maintain smoking behavior, especially smoking mentholated brands of cigarettes, and b) determine AA youths' knowledge, attitudes, i... | 18,822,164 |
Acral lentiginous melanoma of the foot and ankle: A case series and review of the literature. | Acral lentiginous melanoma (ALM) is an uncommon, cutaneous malignant tumour which may arise on the foot. Its relative rarity, atypical appearance and late presentation frequently serve as poor prognostic indicators. At a tertiary skin tumour centre, a retrospective review was undertaken of all patients diagnosed with t... | 18,822,168 |
Prevalence of abnormal glucose metabolism in atrial fibrillation: a case control study in 75-year old subjects. | The prevalence of atrial fibrillation (AF) is increasing world wide and amongst factors that aggravate the risk is diabetes mellitus (DM), also in epidemic development.However, although DM is a potentially modifiable risk factor for AF, few, if any, studies have explored the prevalence of undiagnosed dysglycaemia among... | 18,822,173 |
Leaders, leadership and future primary care clinical research. | A strong and self confident primary care workforce can deliver the highest quality care and outcomes equitably and cost effectively. To meet the increasing demands being made of it, primary care needs its own thriving research culture and knowledge base. Review of recent developments supporting primary care clinical re... | 18,822,178 |
[Effects of over-expressed Smac gene coupling with cisplatin on proliferation and apoptosis of hepatocarcinoma cells]. | To investigate the effects of over-expressed Smac gene combined with cisplatin (CDDP) on proliferation and apoptosis of hepatic carcinoma cells. The recombinant plasmid pcDNA3.1+-hSmac was introduced into the human hepatic carcinoma SMMC-7721 cells using a liposome-mediated method. The expression of Smac protein was de... | 18,822,208 |
[Exogenous surfactant therapy: new synthetic surfactants]. | There are numerous pulmonary conditions in which qualitative or quantitative anomalies of the surfactant system have been demonstrated. In premature newborns with immature lungs, a functional deficit in surfactant is the main physiopathologic mechanism of the neonatal respiratory distress syndrome (RDS). Since the land... | 18,822,258 |
The E163K DJ-1 mutant shows specific antioxidant deficiency. | Recent discoveries of genetic mutations linked to familial forms of Parkinson's disease (PD), including mutations in DJ-1, have provided insights into the pathogenesis of sporadic PD. Recently, a novel homozygous missense mutation in the gene encoding human DJ-1 protein resulting in the E163K amino acid substitution ha... | 18,822,273 |
Direct effect of light on 24-h variation of aqueous humor protein concentration in Sprague-Dawley rats. | Sprague-Dawley rats 10-12 weeks of age were entrained to a standard light-dark cycle with lights turned on at 6 am and off at 6 pm. Variations of 24-h aqueous humor protein concentration were determined. Samples were taken every 4h (N=10-14) under the standard light-dark condition at 8 pm, midnight, 4 am, 8 am, noon, a... | 18,822,284 |
Regenerating cellulose from ionic liquids for an accelerated enzymatic hydrolysis. | The efficient conversion of lignocellulosic materials into fuel ethanol has become a research priority in producing affordable and renewable energy. The pretreatment of lignocelluloses is known to be key to the fast enzymatic hydrolysis of cellulose. Recently, certain ionic liquids (ILs) were found capable of dissolvin... | 18,822,323 |
Alloantigen-induced regulatory CD8+CD103+ T cells. | Regulatory T cells (Tregs) appear of great importance in the balance between alloreactivity and tolerance and subsets of both CD4(+) and CD8(+) T cells have been recognized to function as regulatory T cells after allogenic transplantation. Among the CD8(+) T-cell subsets, the CD103(+) cells were most recently identifie... | 18,822,329 |
Enantioselective cytotoxicity of the insecticide bifenthrin on a human amnion epithelial (FL) cell line. | Synthetic pyrethroids (SPs) are used in preference to organochlorines and organophosphates due to their high efficiency, low toxicity to mammals, and ready biodegradability. Previous studies reported that enantioselective toxicity of SPs occurs in aquatic toxicity. Several studies have indicated that SPs could lead to ... | 18,822,338 |
Evolution of carrying capacity in evolution experiments focusing on a single locus on the Escherichia coli chromosome. | We performed a series of evolution experiments, the results of which illustrated the relationship between mutations and increased carrying capacity (K). Performing an evolution experiment with repeated cycles of mutation by PCR and selection makes it possible to obtain results over shorter culture durations than in met... | 18,822,342 |
Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death. | Massive neuronal activation by glutamate can result in an excessive rise in cytoplasmic calcium, a process ultimately leading to neuronal death. We have investigated the role of the transient receptor potential channel 1 (TRPC1) in mediating glutamate-induced neuron death. We show that 2-APB (a blocker of store-operate... | 18,822,346 |
When they see, they see it almost right: normal subjective experience of detected stimuli in spatial neglect. | Unilateral spatial neglect (USN) patients show reduced contrast sensitivity on their contralesional side and often miss their non-salient stimuli. What their subjective experience is when successfully reporting a stimulus remains unclear. Here, we report that despite large contrast sensitivity differences between the s... | 18,822,347 |
Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva. | It is unknown whether AQP5 and lipid rafts are released into human unstimulated (resting) saliva and saliva in response to secretagogues. In order to quantitate the salivary concentration of AQP5, we produced a polyclonal antibody for human AQP5 and developed an enzyme-like immunosorbent assay (ELISA). AQP5 and lipid r... | 18,822,351 |
Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract. | To investigate the anticonvulsant activity of root bark extract of Carissa edulis. The median lethal dose (LD(50)) of Carissa edulis extract was determined using Lork's method (1983). The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ)-induced convulsion in mice and maximal electroshock ... | 18,822,365 |
Glycosyltransferases, glycoside hydrolases: surprise, surprise! | Several in the field-and many outside-consider that solving the three-dimensional structures of more glycoside hydrolases (GHs) and glycosyltransferases (GTs) confines to stamp collection and some even think that there is no main revelation to expect in this area. It is wrong! The past year has come as a refreshing wak... | 18,822,375 |
Apolipophorin III from Hyphantria cunea shows different anti-oxidant ability against LDL oxidation in the lipid-free and lipid-bound state. | Insect apolipophorin III (apoLp-III) and human apolipoprotein A-I (apoA-I) are major protein constituents of the lipoprotein system that share various properties. In order to compare the anti-oxidant ability of apoLp-III and apoA-I in the lipid-free and lipid-bound state, both proteins were purified and synthesized ind... | 18,822,383 |
Low hanging fruit in infectious disease drug development. | Cost estimates for developing new molecular entities (NME) are reaching non-sustainable levels and coupled with increasing regulatory requirements and oversight have led many pharmaceutical sponsors to divest their anti-microbial development portfolios [Projan SJ: Why is big Pharma getting out of anti-bacterial drug di... | 18,822,387 |
Population genomics: diversity and virulence in the Neisseria. | Advances in high-throughput nucleotide sequencing and bioinformatics make the study of genomes at the population level feasible. Preliminary population genomic studies have explored the relationships among three closely related bacteria, Neisseria meningitidis, Neisseria gonorrhoeae and Neisseria lactamica, which exhib... | 18,822,386 |
Development of the Gateway system for cloning and expressing genes in Entamoeba histolytica. | The early branching eukaryote Entamoeba histolytica is a human parasite that is the etiologic agent of amebic dysentery and liver abscess. The sequencing of the E. histolytica genome combined with the development of an E. histolytica microarray has resulted in the identification of several distinct gene expression prof... | 18,822,389 |
Induction of late airway response was involved in serum antigen-specific immunoglobulin G in rats. | The antigen-induced immediate airway response (IAR) has been considered a form of bronchoconstriction mainly provoked by histamine and leukotriene C4/D4/E4, which are released by stimulation by antigen-specific IgE. However, the pathophysiological features of the antigen-induced late airway response (LAR) are not yet f... | 18,822,391 |
A thixotropic hydrogel from chemically cross-linked guar gum: synthesis, characterization and rheological behaviour. | Polysaccharide guar gum (GG) was cross-linked in an alkaline solution with polyethylene glycol diglycidyl ether (PEGDGE) to create a new hydrogel. The GG hydrogel was examined by FT-IR spectroscopy, AFM analysis and SEM analysis. The water uptake of the GG hydrogel was measured at different pHs, and rheological studies... | 18,822,410 |
Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF study. | High-density-lipoproteins-cholesterol (HDL-C) is invertedly related to the incidence of cardiovascular events. Recent studies suggest that HDL-C directly improves endothelial function. Nicotinic acid (niacin) effectively raises serum HDL-C. We therefore hypothesized that treatment with niacin improves endothelial dysfu... | 18,822,413 |
Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants. | To assess the effectiveness of early prophylactic milrinone versus placebo for prevention of low systemic blood flow in high-risk preterm infants. Double-blind randomized placebo controlled trial of milrinone (loading dose 0.75 microg/kg/min for 3 hours then maintenance 0.2 microg/kg/min until 18 hours after birth) ver... | 18,822,428 |
The implications of immunogenicity for protein-based multiple sclerosis therapies. | Administered proteins are inherently immunogenic, which may influence their efficacy or safety when used therapeutically. A review of the published literature was performed to compare and evaluate the development and consequences of antibodies against therapeutic protein agents for the treatment of multiple sclerosis (... | 18,822,434 |
Toxoplasma gondii infection in pregnant women in China. | Infection with Toxoplasma gondii is common and usually asymptomatic, but it can have serious consequences in pregnant women if passed to the developing fetus. The aims of this study were to determine the prevalence of toxoplasmosis in pregnant women and to identify the possible risk factors associated with T. gondii in... | 18,822,439 |
Toward understanding the mechanism of improving the production of volatile fatty acids from activated sludge at pH 10.0. | A well-defined fractionation approach for sludge flocs was applied to a better understanding of the underlying mechanism of improving the production of volatile fatty acids (VFA) in the hydrolysis and acidification processes at pH 10.0. Specifically, sludge flocs were fractionated through centrifugation and ultrasound ... | 18,822,441 |
Polychlorinated dibenzo-p-dioxins and dibenzofurans in soils and sediments from Daliao River Basin, China. | Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) were analyzed in surface sediments and top soils collected from 30 sites in Daliao River Basin. The concentrations of PCDD/F ranged from 0.28 to 29.01 ng TEQ kg(-1) dw (mean value, 7.45 ng TEQ kg(-1)dw) in sediments, and from 0.31 to 53.05 ng ... | 18,822,443 |
Minimal effect of cold ischemia time on progression to late-stage chronic kidney disease observed long term after partial nephrectomy. | To assess the influence of cold ischemia on postoperative renal function and the new onset of late-stage chronic kidney disease during long-term follow-up after partial nephrectomy. A total of 131 patients with renal tumors who underwent partial nephrectomy and were followed up for >or=12 months were included in the... | 18,822,449 |
The newer the better? Comparison of the 1997 and 2001 partin tables for pathologic stage prediction of prostate cancer in China. | The use of the Partin tables for pathologic stage prediction of prostate cancer in China has 2 problems. First, the validity of such U.S.-derived predictive tools has not been tested in China. Second, because an updated version of the Partin tables created using a more contemporary cohort was introduced in 2001, it is ... | 18,822,453 |
Clinical manifestations of hyperuricemia and gout. | Biologically significant hyperuricemia occurs when serum urate levels exceed urate solubility, ie, at approximately 6.8 mg/dL. At serum urate levels above this threshold, manifestations of chronic crystal deposition, including gouty arthritis, may occur, although asymptomatic hyperuricemia often persists for many years... | 18,822,469 |
[Anopheles mosquitoes (Diptera, Culicidae) of the Tien Shan: morphological, cytogenetic, and molecular genetic analysis]. | Morphological, cytogenetic, and molecular genetic studies of the Anopheles fauna in the valley and foothills of the Tien Shan identified 5 species of malaria mosquitoes: An. artemievi Gordeev et al., An. messeae Fall, An. claviger Meigen, An. hyrcanus Pallas, An. pulcherrimus Theobald, and superpictus Grassi. An. clavi... | 18,822,504 |
Response to a combined treatment program with clomipramine, behavioral, and environmental management of compulsive tail chasing in a German Shepherd. | A 15-month-old female German Shepherd dog showing compulsive tail chasing was treated with a treatment protocol of pharmacological therapy (using clomipramine) in conjunction with behavioral and environmental management. The responses to the treatment protocol were assessed once a week for 7 weeks in respects to behavi... | 18,822,603 |
[Estimation of genetic parameters for radiographic signs of hip dysplasia in Labrador Retrievers]. | The aim of this study was the analysis of environmental factors and estimation of genetic parameters for hip dysplasia in Labrador Retrievers. We analysed hip dysplasia scores of 2970 dogs from the official screening programme of the Labrador Club Deutschland (LCD) according to the FCI protocols. Traits evaluated were ... | 18,822,607 |
Fatal cerebral abscess caused by Cladophialophora bantiana. | Primary cerebral phaeohyphomycosis is caused by pigmented fungi that exhibit distinct neurotropism often in immunocompetent individuals. A 20-yr-old male presented with multiple brain abscess which was subsequently proven microbiologically to be due to Cladophialophora Bantiana. In spite of near total excision and appr... | 18,822,631 |
Is ascending urethrogram mandatory for all urethral strictures? | To determine the role of ascending urethrogram in decision making for patients with suspected urethral strictures. Medical Records were reviewed of male patients presenting with lower urinary tract symptoms who were subjected to ascending urethrogram and selected cases for cystourethroscopy from January 2001 to Decembe... | 18,822,639 |
Primary drug resistance to antituberculous drugs in NWFP Pakistan. | To assess the prevalence of Primary drug resistance to Antituberculous drugs in NWFP METHOD: A cross-sectional prevalence study was undertaken to evaluate the prevalence of drug resistance among new TB patients, using a non-probability convenience sampling methodology. Sample size was calculated according to the popula... | 18,822,641 |
Awareness of bird flu amongst young college students. | To assess the awareness among students about the disease, their attitude during the outbreak, along with their perceptions about treatment, and severity of disease. A cross sectional study was conducted among 220 intermediate students. The data was collected through a self filled questionnaire after taking verbal conse... | 18,822,652 |
On microRNA and the need for exploratory experimentation in post-genomic molecular biology. | This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it ... | 18,822,659 |
Clinical update on palonosetron in the management of chemotherapy-induced nausea and vomiting. | The need to control chemotherapy-induced nausea and vomiting is continuously stimulating research to find better options for the optimal antiemetic care. Palonosetron is different from conventional serotonin receptor antagonists not only by the fact of having a longer half-life but also by higher binding affinity for s... | 18,822,676 |
Stromal tumors of the stomach: a clinicopathological study of 15 cases and review of the literature. | Gastrointestinal stromal tumors are the most common mesenchymal tumors of the digestive tract, although their incidence is low. These tumors make up a unique entity based on their molecular pathogenesis, immunohistochemical staining and responsiveness to targeted therapy. Gastrointestinal stromal tumors vary in maligna... | 18,822,678 |
Retroperitoneal soft tissue sarcoma: prognostic factors and therapeutic approaches. | Retroperitoneal sarcomas are a rare group of malignant soft tissue tumors with a generally poor prognosis. The aim of the study was to assess clinical, pathological and treatment-related factors affecting prognosis in patients with retroperitoneal sarcomas. The hospital records of 73 patients who underwent surgical exp... | 18,822,685 |
Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma. | To investigate the expression of TSPAN1 (Gene ID: 10103), Ki67 and CD34 in gastric carcinomas and the clinicopathological significance, the expression of TSPAN1, Ki67 and CD34 was detected in 86 cases of gastric carcinoma, paraffin-embedded sections using an immunohistochemical method. The rates of overexpression of TS... | 18,822,690 |
[Experimental study on neural stem cell transplantation delaying denervated muscle atrophy]. | To observe the delaying effect of neural stem cell (NSC) transplantation on denervated muscle atrophy after peripheral nerve injury, and to investigate its mechanism. NSCs were separated from the spinal cords of green fluorescent protein (GFP) transgenic rats aged 12-14 days mechanically and were cultured and induced t... | 18,822,726 |
[Study on treating residual cavity of body surface after abscess drainage by sodium hyaluronate hydrogel]. | To study the effect of sodium hyaluronate hydrogel in treating residual cavity on body surface after abscess drainage so as to provide new method to speed up the healing of residual cavity after body surface abscess drainage and reduce the frequency of dressing change and clinic nursing workload. From June 2007 to Marc... | 18,822,733 |
[Investigation of new classification and repair methods for fingertip traverse amputation]. | To investigate new classification and repair methods for the traverse amputated fingertip. From March 2000 to October 2006, 20 cases of 20 fingers with traverse amputated fingertip, including 13 males and 7 females aged 17-47 years, were treated. Twenty patients (9 crush injuries, 5 cutting injuries and 6 sawing injuri... | 18,822,735 |
[Microvascular decompression for cranial nerve hyperactive dysfunction]. | To assess the results of microvascular decompression (MVD) in treating cranial nerve hyperactive dysfunction. From October 2002 to January 2007, 106 patients with cranial never hyperactive dysfunction were treated with MVD. Among them, there were 47 males and 59 females with an average age of 62 years (42-85 years), in... | 18,822,736 |
[The relationship between the family member and the child with AIDS: understanding in the light of Martin Buber]. | This qualitative study with a phenomenological approach aimed at understanding what it means to be a family caregiver of a child living with the Acquired Immunodeficiency Syndrome (AIDS) in the light of Martin Buber's philosophy. The study was carried out at the Pediatric outpatient Unit of a teaching hospital of Porto... | 18,822,758 |
[Patient satisfaction in a laboratory test collection unit]. | This exploratory descriptive study aimed at identifying customer satisfaction attributes in the field of laboratory tests. Data were collected in 2006, using 104 interviews in a laboratorial unit inside a teaching hospital, using the critical incident technique, and submitted to content analysis. Three attribute catego... | 18,822,760 |
[Pain similarities and differences in the chest syndromes: systematic literature review]. | Clinical conditions that present chest pain should be its causes quickly and precisely diagnosed. The objective of this study was to identify the existence of specific and common pain characteristics in acute myocardial infarction, angina, pericarditis, dissected thoracic aorta, and esophagus conditions. A systematic l... | 18,822,764 |
[Effect of growth conditions on the molecular weight of poly-3-hydroxybutyrate produced by Azotobacter chroococcum 7B]. | It has been shown that poly-3-hydroxybutyrate (PHB) of predetermined molecular weight can be obtained by varying the growth conditions of the producer strain, Azotobacter chroococcum 7B: pH, temperature, aeration, presence of sodium acetate as an additional carbon source, or growth on crude complex carbon sources (mola... | 18,822,772 |
[Posttranslation regulation of programmable cell events in unicellular eukaryotes]. | The review considers the up to date achievements about posttranslational regulation of programmable cell events: growth, development, and apoptosis in unicellular eukaryotes mediated by histone modifications and DNA metylation. Special attention is given to the evolution aspects of the problem. | 18,822,786 |
Orientation sensitive properties of visually driven neurons in extrastriate area 21a of cat cortex. | Orientation sensitive properties of extrastriate area 21a neurons were investigated. Special attention was paid to the qualitative characteristics of neuron responses to the different orientations of visual stimulus motion across neuron classical receptive fields (CRF). The results of experiments have shown that a grou... | 18,822,799 |
Sealants fight back aginst bacteria. | Mike Moran, business development manager, Industrial Construction, at Bostik, explains how a range of new sealants increase protection in hospital bathrooms, shower rooms and kitchen facilities against healthcare-acquired infections. | 18,822,825 |
[Ultrastructural aspects of intercostal muscles in patients with COPD]. | The studies to the electron microscope have shown that external and internal intercostal muscles present characteristic changes of ultra structural organization in COPD. The diameter of muscle fibers become unequal, sarcolemma shows frequently deep invaginations, having in the near sarcoplasma concentrations of mitocho... | 18,822,871 |
[Investigation of anti-R7V antibodies in HIV-infected patients under highly active antiretroviral therapy]. | R7V is a seven-aminoacid peptide epitope derived from cellular beta-2 microglobulin, present on human immunodeficiency virus (HIV) virion surface in patients with HIV infection. Antibodies against R7V peptide have the property of neutralizing all strains of HIV, unrelated to genotype, phenotype, or geographical origin ... | 18,822,884 |
[Nosocomial meningitis with dual agents and treatment with intraventricular gentamicin]. | Nosocomial central nervous system infections constitute 0.4% of all nosocomial infections. The responsible pathogens of nosocomial meningitis are quite different from community-acquired meningitis with high rates of morbidity and mortality. The most important prognostic factor is the appropriate choice of pathogen-spec... | 18,822,895 |
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