title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Differential distribution of synGAP alpha1 and synGAP beta isoforms in rat neurons. | The synaptic Ras-GTPase activating protein synGAP is a brain-specific protein of approximately 130 kDa and is a negative regulator of Ras. We previously reported 5 C-terminal isoforms of synGAP (alpha1, alpha2, beta1/2, beta 3/4 and gamma) [Li et al., 2001, J. Biol. Chem. 276: 21417-21424]. In this study, we investigat... | 18,824,155 |
High glucose increases RAW 264.7 macrophages activation by lipoteichoic acid from Staphylococcus aureus. | Type 2 diabetes mellitus is associated with an increased risk of cardiovascular diseases and accelerated atherosclerosis, which has been associated to hyperglycemia and chronic inflammation. Activated macrophages are described to participate in atherosclerosis due to foam cell formation and pro-inflammatory mediators p... | 18,824,162 |
Long-term cyclic stretch controls pulmonary endothelial permeability at translational and post-translational levels. | We have previously described differential effects of physiologic (5%) and pathologic (18%) cyclic stretch (CS) on agonist-induced pulmonary endothelial permeability. This study examined acute and chronic effects of CS on agonist-induced intracellular signaling and cell morphology in the human lung macro- and microvascu... | 18,824,167 |
Serial culture of murine primary airway epithelial cells and ex vivo replication of human rhinoviruses. | Human rhinoviruses (HRV) are the primary etiological agents in cold infections, and represent a serious risk to individuals with chronic respiratory disease such as asthma. In order to develop treatment options for HRV infections, murine models are a crucial component in the study of infection mechanisms due to the wid... | 18,824,171 |
Neurophysiological indices of perceptual object priming in the absence of explicit recognition memory. | The aim of this study was to identify ERP correlates of perceptual object priming that are insensitive to factors affecting explicit, episodic memory. EEG was recorded from 21 participants while they performed a visual object recognition test on a combination of unstudied items and old items that were previously encoun... | 18,824,201 |
Frontal-midline theta from the perspective of hippocampal "theta". | Electrical recordings from the surface of the skull have a wide range of rhythmic components. A major task of analysis of this EEG is to determine their source and functional significance. The hippocampal "theta rhythm" has been extensively studied in rats and its rhythmicity has recently been shown to be functionally ... | 18,824,212 |
Intranasal administration of progesterone increases dopaminergic activity in amygdala and neostriatum of male rats. | We evaluated the effects of intranasal administration of progesterone (PROG) on the activity of dopaminergic neurons in the brain of anesthetized rats by means of microdialysis. Male Wistar rats were implanted with guide cannulae in the basolateral amygdala and neostriatum. Three to 5 days later, they were anesthetized... | 18,824,215 |
The CYPome (Cytochrome P450 complement) of Aspergillus nidulans. | The cytochromes P450 (CYPs) are found in all biological kingdoms and genome sequencing projects continue to reveal an ever increasing number. The principle aim of this paper is to identify the complete CYPome of Aspergillus nidulans from the genome sequence version AN.3 deposited at the Broad institute, assign the appr... | 18,824,241 |
Physiological relevance of GPCR oligomerization and its impact on drug discovery. | The potentially large functional and physiological diversity of G-protein coupled receptor (GPCR) dimers has generated a great deal of excitement about the opportunity that dimerization provides for enabling novel drug discovery. The discovery of physiologically relevant GPCR dimers suggests that new drug targets for d... | 18,824,244 |
New therapeutics for the prevention and reduction of scarring. | Published literature shows that both physicians and patients are highly concerned about scarring and value even small improvements in scar appearance. Both severe and relatively minor scars can have a significant psychological impact on patients, irrespective of whether or not they are hidden by clothing. There is no u... | 18,824,245 |
Inhibitory effect of olive oil on fibrosis induced by carbon tetrachloride in rat liver. | In this study, the inhibitory effect of olive oil on liver fibrosis induced by carbon tetrachloride (CCl(4)) has been investigated in rats. Rats were divided randomly into four groups: control, CCl(4), and two olive oil groups. Except for rats in the control group, all rats were orally administered CCl(4) twice a week ... | 18,824,281 |
C60 fullerene: a powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays. | Since the discovery of fullerenes in 1985, these carbon nanospheres have attracted attention regarding their physico/chemical properties. Despite little knowledge about their impact on the environment and human health, the production of fullerenes has already reached an industrial scale. However, the toxicity of C(60) ... | 18,824,284 |
Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer. | In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 7... | 18,824,294 |
Ametryn degradation in the ultraviolet (UV) irradiation/hydrogen peroxide (H2O2) treatment. | Ultraviolet (UV) irradiation (253.7nm) in the presence of hydrogen peroxide (H(2)O(2)) was used to decompose aqueous ametryn. The concentrations of ametryn were measured with time under various experiment conditions. The investigated factors included H(2)O(2) dosages, initial pH, initial ametryn concentrations, and a v... | 18,824,296 |
[Inhibition of bacterial adhesion and prevention of biofilm formation: Use of organic self-assembled monolayers on inorganic surfaces]. | Implant related nosocomial infections are a serious public health concern. Colonisation by contaminating bacteria of the bare implant surface may lead to the formation of a biofilm protecting bacteria against host defences and antibiotics. To decrease the risk of infection, a strategy is to modify the biomaterial surfa... | 18,824,310 |
Cloning and expression of an antifungal chitinase gene of a novel Bacillus subtilis isolate from Taiwan potato field. | A chitinase producing Bacillus subtilis CHU26 was isolated from Taiwan potato field. This strain exhibited a strong extra-cellular chitinase activity on the colloidal chitin containing agar plate, and showed a potential inhibit activity against phytopathogen, Rhizoctonia solani. The gene encoding chitinase (chi18) was ... | 18,824,348 |
Validation of two echocardiographic indexes to improve the diagnosis of complex coarctations. | Coarctation of the aorta is one of the most common congenital heart defects. Its diagnosis may be difficult in the presence of a patent ductus arteriosus, of other complex defects or of a poor echocardiographic window. We sought to demonstrate that the carotid-subclavian artery index (CSA index) and the isthmus-descend... | 18,824,366 |
[Median nerve entrapment after fracture dislocation of the elbow: a two-cases report]. | The median nerve entrapment after elbow-dislocation is rare. We report two cases of fracture dislocation elbow completed by entrapment of median nerve occurred after reduction in two children. For both cases, the diagnosis of entrapment was made some months later after injury. Median nerve graft was performed after ner... | 18,824,386 |
Evaluation of stretching position by measurement of strain on the ilio-femoral ligaments: an in vitro simulation using trans-lumbar cadaver specimens. | The ilio-femoral ligament is known to cause flexion contracture of the hip joint. Stretching positioning is intended to elongate the ilio-femoral ligaments, however, no quantitative analysis to measure the effect of stretching positions on the ligament has yet been performed. Strains on the superior and inferior ilio-f... | 18,824,394 |
The relocation of starch metabolism to chloroplasts: when, why and how. | Plastid endosymbiosis was accompanied by the appearance of a novel type of semi-cristalline storage polysaccharide (starch). Interestingly, starch is found in the cytoplasm of Rhodophyceae and Glaucophyta but is localized to the chloroplast stroma of Chloroplastida. The pathway is presumed to have been cytosolic in the... | 18,824,400 |
Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos. | During human preimplantation development, early blastomeres are believed to be totipotent. It is likely, however, that blastomeres are allocated to a specific lineage prior to any morphological differentiation. NANOG, SOX2 and SALL4 are transcription factors that play a key role in controlling stemness in embryonic ste... | 18,824,471 |
A dose distribution overlay technique for image guidance during prostate radiotherapy. | Adaptive radiotherapy involves altering the treatment plan according to variations in patient anatomy and set-up. This relies upon an accurate representation of the changing dose distribution within the patient, requiring a full dose recalculation. This work proposes a novel workflow using the planned dose distribution... | 18,824,502 |
The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. | IkappaBalpha binds to and inhibits the transcriptional activity of NF-kappaB family members via its ankyrin repeat (AR) domain. The binding affinity of IkappaBalpha with NF-kappaB(p50/p65) heterodimers and NF-kappaB(p65/65) homodimers is in the picomolar range, and in the cell, this results in long half-lives of the co... | 18,824,506 |
Characterization of the termination-reinitiation strategy employed in the expression of influenza B virus BM2 protein. | Coupled expression of the M1 and BM2 open-reading frames (ORFs) of influenza B from the dicistronic segment 7 mRNA occurs by a process of termination-dependent reinitiation. The AUG start codon of the BM2 ORF overlaps the stop codon of the upstream M1 ORF in the pentanucleotide UAAUG, and BM2 synthesis is dependent upo... | 18,824,510 |
Diurnal variation in phagocytic activity of splenic phagocytes in freshwater teleost Channa punctatus: melatonin and its signaling mechanism. | The aim of the present study was to understand the rhythmic changes in innate immune response in freshwater fish Channa punctatus. Furthermore, the putative role of melatonin as the zeitgeber was explored. The phagocytic activity of splenic phagocytes assessed at 6-h intervals showed higher phagocytic activity during l... | 18,824,520 |
A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism. | The monkey CYP2C76 gene does not correspond to any of the human CYP2C genes, and its enzyme is at least partly responsible for the species difference occasionally seen in drug metabolism between monkeys and humans. To establish a line and/or lines of monkeys that are expected to show metabolic patterns highly similar t... | 18,824,522 |
High-affinity interaction of sartans with H+/peptide transporters. | Sartans are very effective drugs for treatment of hypertension, heart failure, and other cardiovascular disorders. They antagonize the effects of angiotensin II at the AT(1) receptor and display p.o. bioavailability rates of 13 to 80%. Because some sartans sterically resemble dipeptide derivatives, we investigated whet... | 18,824,524 |
Adenoviral delivery of interleukin-10 fails to attenuate experimental Lyme disease. | Production of interleukin-10 (IL-10) by C57BL/6 mice following infection with Borrelia burgdorferi has been proposed as a mechanism whereby resistance to the development of experimental Lyme arthritis is maintained. In the current study, we sought to determine the role of IL-10 during infection of arthritis- and cardit... | 18,824,530 |
Mycobacterium avium glycopeptidolipids require specific acetylation and methylation patterns for signaling through toll-like receptor 2. | Toll-like receptors (TLRs) recognize pathogen-associated molecules and play a vital role in promoting an immune response against invading microbes. TLR2, one of the key members of the TLR family, recognizes a wide variety of microbial products, including lipoproteins and lipopeptides, from a number of pathogens. Recent... | 18,824,550 |
Costs and cost-effectiveness of different follow-up schedules for detection of occupational hepatitis C virus infection. | The purpose of this study was to compare the costs and cost-effectiveness (C/E) of early hepatitis C virus (HCV) RNA testing (alternative-US recommendations) after occupational exposure to HCV with existing follow-up strategies: (1) French, anti-HCV antibodies and alanine transaminase (ALT) activity at months 1, 3 and ... | 18,824,553 |
Prospective evaluation of mitotane toxicity in adrenocortical cancer patients treated adjuvantly. | Toxicity of adjuvant mitotane treatment is poorly known; thus, our aim was to assess prospectively the unwanted effects of adjuvant mitotane treatment and correlate the findings with mitotane concentrations. Seventeen consecutive patients who were treated with mitotane after radical resection of adrenocortical cancer (... | 18,824,557 |
Metastases but not cardiovascular mortality reduces life expectancy following surgical resection of apparently benign pheochromocytoma. | The treatment of choice for non-metastatic pheochromocytoma is surgical resection. Its goals are to abolish catecholamine hypersecretion, normalize blood pressure, and prevent further tumor growth or progression to metastatic disease. Data on long-term mortality and morbidity after pheochromocytoma surgery are limited.... | 18,824,558 |
Glycobiology on the fly: developmental and mechanistic insights from Drosophila. | Drosophila melanogaster offers many unique advantages for deciphering the complexities of glycan biosynthesis and function. The completion of the Drosophila genome sequencing project as well as the comprehensive catalogue of existing mutations and phenotypes have lead to a prolific database where many of the genes invo... | 18,824,561 |
The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes. | The accuracy of chromosome segregation is enhanced by the spindle assembly checkpoint (SAC). The SAC is thought to monitor two distinct events: attachment of kinetochores to microtubules and the stretch of the centromere between the sister kinetochores that arises only when the chromosome becomes properly bioriented. W... | 18,824,563 |
Notch1 signaling stimulates proliferation of immature cardiomyocytes. | The identification of the molecular mechanisms controlling cardiomyocyte proliferation during the embryonic, fetal, and early neonatal life appears of paramount interest in regard to exploiting this information to promote cardiac regeneration. Here, we show that the proliferative potential of neonatal rat cardiomyocyte... | 18,824,567 |
Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination. | Immunoglobulin (Ig) class switch recombination (CSR) deficiencies are rare primary immunodeficiencies characterized by the lack of switched isotype (IgG/IgA/IgE) production. In some cases, CSR deficiencies can be associated with abnormal somatic hypermutation. Analysis of CSR deficiencies has helped reveal the key func... | 18,824,584 |
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. | Controlled regulation of Rho GTPase activity is an essential component mediating growth factor-stimulated migration. We have previously shown that angiomotin (Amot), a membrane-associated scaffold protein, plays a critical role during vascular patterning and endothelial migration during embryogenesis. However, the sign... | 18,824,598 |
Commercial sex and HIV transmission in mature epidemics: a study of five African countries. | The study compares the association between using the services of commercial sex workers and male HIV seroprevalence in five African countries: Ghana, Kenya, Lesotho, Malawi and Rwanda. The HIV seroprevalence among men who 'ever paid for sex' was compared with controls who 'never paid for sex'. Results were based on 12,... | 18,824,616 |
Syphilis causing hearing loss. | An HIV-positive man with hepatitis B co-infection, naïve to highly active antiretroviral therapy, with a CD4 of 594 copies/mL and HIV-1 viral load of 140,070 copies, presented with right-sided facial weakness and hearing loss. He had been treated for secondary syphilis three months earlier when his rapid plasma reagin ... | 18,824,631 |
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells. | Dimethylarginine dimethylaminohydrolase (DDAH) is an enzyme that metabolizes asymmetrical N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA), which are competitive endogenous inhibitors of NO synthase. However, it remains unknown whether NO itself influences DDAH activity and/or ADMA/MMA contents... | 18,824,664 |
The "Cheshire Cat" escape strategy of the coccolithophore Emiliania huxleyi in response to viral infection. | The coccolithophore Emiliania huxleyi is one of the most successful eukaryotes in modern oceans. The two phases in its haplodiploid life cycle exhibit radically different phenotypes. The diploid calcified phase forms extensive blooms, which profoundly impact global biogeochemical equilibria. By contrast, the ecological... | 18,824,682 |
Caulobacter requires a dedicated mechanism to initiate chromosome segregation. | Chromosome segregation in bacteria is rapid and directed, but the mechanisms responsible for this movement are still unclear. We show that Caulobacter crescentus makes use of and requires a dedicated mechanism to initiate chromosome segregation. Caulobacter has a single circular chromosome whose origin of replication i... | 18,824,683 |
Kinetic regulation of coated vesicle secretion. | The secretion of vesicles for intracellular transport often relies on the aggregation of specialized membrane-bound proteins into a coat able to curve cell membranes. The nucleation and growth of a protein coat is a kinetic process that competes with the energy-consuming turnover of coat components between the membrane... | 18,824,695 |
Association between hepatitis B virus and pancreatic cancer. | Hepatitis B virus (HBV) and hepatitis C virus (HCV) are considered to be hepatotropic and are a major cause of hepatocellular carcinoma. However, little is known about the role of HBV and HCV infection in other malignancies. This study aimed to determine whether HBV and HCV infections increase the risk for pancreatic c... | 18,824,707 |
Availability and use of palliative care and end-of-life services for pediatric oncology patients. | Palliative care prevents or relieves the symptoms caused by life-threatening medical conditions. Previous surveys have shown both underuse and lack of availability of these services for children with cancer throughout North America. We sought to investigate the current practices and resources surrounding palliative and... | 18,824,711 |
Mucosal IgA increase in rats by continuous CLA feeding during suckling and early infancy. | The aim of this work was to establish the effect of the cis9,trans11 conjugated linoleic acid (CLA) isomer on mucosal immunity during early life in rats, a period when mucosal immunoglobulin production is poorly developed, as is also the case in humans. CLA supplementation was performed during three life periods: gesta... | 18,824,724 |
Upper and lower tear menisci on contact lenses. | The purpose of this study was to measure upper and lower tear menisci on contact lenses using real time optical coherence tomography (OCT). Both eyes of 20 adapted contact lens wearers were imaged when they wore two types of silicone hydrogel lenses, balafilcon A on one eye and galyfilcon A on the other eye. The height... | 18,824,725 |
Rod and rod-driven function in achromatopsia and blue cone monochromatism. | To evaluate rod photoreceptor and postreceptor retinal function in pediatric patients with achromatopsia (ACHR) and blue cone monochromatism (BCM) using contemporary electroretinographic (ERG) procedures. Fifteen patients (age range, 1-20 years) with ACHR and six patients (age range, 4-22 years) with BCM were studied. ... | 18,824,728 |
Tight heart rate control reduces secondary adverse events in patients with type B acute aortic dissection. | Although type B aortic dissection has been treated with beta blockers to lower the arterial blood pressure (BP), there has been little evidences about reduction in heart rate (HR). We assessed whether tight HR control improved the outcome of medical treatment in patients with aortic dissection. From 1997 to 2005, 171 p... | 18,824,750 |
Survival after resection of primary cardiac tumors: a 48-year experience. | Primary cardiac tumors are rare but have the potential to cause significant morbidity if not treated in an appropriate and timely manner. To date, however, there have been no studies examining survival characteristics of patients who undergo surgical resection. From 1957 to 2006, 323 consecutive patients underwent surg... | 18,824,772 |
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis. | Vascular injury results in loss of endothelial nitric oxide (NO), production of reactive oxygen species (ROS), and the initiation of an inflammatory response. Both NO and ROS modulate inflammation through redox-sensitive pathways. Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase ... | 18,824,773 |
Hydrological analysis of single and dual storage systems for stormwater harvesting. | As stormwater flows are intermittent, the requirement to store urban runoff is important to the design of a stormwater re-use scheme. In many urban areas, the space available to provide storage is limited and thus the need to optimise the storage volume becomes critical. This paper will highlight the advantages and dis... | 18,824,802 |
Pretreatment of wastewater containing a mixture of organic pollutants obtained from a CC2 plant by coagulation. | Coagulation is one of the most important physicochemical treatment steps in industrial wastewater to reduce the suspended and colloidal materials responsible for colour and turbidity of the wastewater. The manufacturing plant of N,N'-Dichloro bis (2,4,6-trichlorophenyl) urea (CC2) produces wastewater containing pyridin... | 18,824,806 |
Global issues related to the impact of untreated attention-deficit/hyperactivity disorder from childhood to young adulthood. | Attention-deficit/hyperactivity disorder (ADHD) is a common, chronic, and costly disorder, with an impact that can span from preschool into adulthood. There are safe and effective therapies that can manage and help prevent many of the associated negative outcomes of ADHD, but treatment rates are far from optimal and co... | 18,824,825 |
Comparison of the Sensititre YeastOne colorimetric antifungal panel with the modified Clinical and Laboratory Standards Institute broth microdilution (M38-A) method for antifungal susceptibility testing of dermatophytes. | To compare the susceptibility of different dermatophyte species to itraconazole (I), fluconazole (F) and voriconazole (V) by the modified reference (microdilution, CLSI M38-A) and the colorimetric method Sensititre YeastOne. The microdilution method is not very practical for use in routine susceptibility testing in the... | 18,824,849 |
Hashimoto's thyroiditis in Down's syndrome: clinical presentation and evolution. | It was the aim of this study to describe the presentation and clinical course of Hashimoto's thyroiditis (HT) in children with Down's syndrome (DS) in 2 Scottish health regions. We retrospectively analysed clinical, biochemical and thyroid antibody status in 38 patients with DS with HT diagnosed from 1989 to 2004. The ... | 18,824,866 |
Nitric oxide involvement in TNF-alpha and IL-1 beta-mediated changes in human mesangial cell MMP-9 and TIMP-1. | Mesangial cells are known to secrete metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) that are capable of disrupting the glomerular basement membrane (GBM). Disruption of the GBM appears to be an important mechanism in the renal disease process, however little is known about the mechanisms ... | 18,824,875 |
Marker development for erect versus pendant-orientated fruit in Capsicum annuum L. | The erect habit of fruit setting is a unique characteristic of ornamental peppers and wild pepper species. The erect habit is known to be controlled by the up locus on pepper (Capsicum annuum L.) chromosome 12. The result of a genetic analysis using Saengryeog 211 (pendant), Saengryeog 213 (erect), and their F1 and BC1... | 18,824,887 |
Treatment-related risk factors for hospital mortality in Candida bloodstream infections. | To examine the relationship between treatment-related variables for Candida bloodstream infection and hospital mortality. Retrospective cohort analysis. Thousand two hundred-bed academic medical center. A total of 245 consecutive patients with Candida bloodstream infections who received antifungal therapy. Identificati... | 18,824,910 |
Education of patients after whiplash injury: is oral advice any better than a pamphlet? | Randomized parallel-group trial with 1-year follow-up. To evaluate whether education of patients communicated orally by a specially trained nurse is superior to giving patients a pamphlet after a whiplash injury. Long-lasting pain and physical disability after whiplash injuries are related to both serious personal suff... | 18,824,949 |
Therapeutic drug monitoring of ziprasidone in a clinical treatment setting. | There is limited information on the pharmacokinetics ofziprasidone (ZIP) in naturalistic clinical settings. The objective of this study was to investigate the concentrations of ZIP and its active metabolite S-methyl-dihydroziprasidone (SMDZ), and the dose-normalized concentrations, using routine therapeutic drug monito... | 18,824,954 |
The utility of onyx for preoperative embolization of cranial and spinal tumors. | To assess the utility, technical factors, and complications associated with the use of Onyx (Micro Therapeutics, Inc., Irvine, CA) for preoperative embolization of cranial and spinal tumors. We reviewed a prospectively accumulated database for patients in whom Onyx was used for preoperative embolization of cranial and ... | 18,824,987 |
Surgical management of unruptured intracranial aneurysms that are inappropriate for endovascular treatment: experience based on two academic centers. | To analyze the results of the surgical management of unruptured intracranial aneurysms (UIA) when coil embolization (CE) was considered first but deemed inappropriate by our multidisciplinary groups. In two institutions, all UIAs recommended for treatment were considered first for a CE procedure if accessibility, neck ... | 18,824,989 |
The current role of microsurgery for posterior circulation aneurysms: a selective approach in the endovascular era. | During the past decade, management of posterior circulation aneurysms has shifted away from microsurgery. Currently, microsurgical clipping is considered a primary, competitive alternative to endovascular coiling, or more commonly, a secondary alternative when endovascular therapy is unfavorable. We present a large, mu... | 18,824,990 |
Evidence of inflammatory cell involvement in brain arteriovenous malformations. | Brain arteriovenous malformations (AVM) have high matrix metalloproteinase-9, interleukin-6, and myeloperoxidase (MPO) expression, and polymorphic variations in inflammatory genes are associated with an increased risk of hemorrhage. In this study, we characterized the presence of inflammatory cells in AVM lesional tiss... | 18,825,001 |
Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence. | Secondary lymphoid organs (SLOs) are tissues that facilitate the induction of adaptive immune responses. These organs capture pathogens to limit their spread throughout the body, bring antigen-presenting cells into productive contact with their cognate lymphocytes and provide niches for the differentiation of immune ef... | 18,825,130 |
Are female lower urinary tract symptoms alleviated by alpha-adrenoreceptor antagonists? | This commentary discusses the article by Low and colleagues, who studied the effect of terazosin in women with lower urinary tract symptoms (LUTS) and an International Prostate Symptom Score (IPSS) > o =8. Terazosin therapy significantly improved IPSS quality-of-life scores and King's Health Questionnaire scores. Th... | 18,825,132 |
The Boston Acute Stroke Imaging Scale: ready for use in clinical practice? | This Practice Point commentary discusses a report by Torres-Mozqueda et al. on a newly developed classification instrument for predicting outcome after stroke, the Boston Acute Stroke Imaging Scale (BASIS). This tool incorporates imaging data on the patency of the vasculature and the parenchyma and classifies ischemic ... | 18,825,146 |
Vaccination with dendritic cells pulsed with homogenate protein of spinal cord promotes functional recovery from spinal cord injury in mice. | Randomized, double-blinded animal experiment for neural functional recovery from spinal cord injury (SCI) through vaccination with immature dendritic cells (DCs) pulsed with homogenate protein of spinal cord (hpDCs) in mice. To study the effect of hpDCs in the recovery from SCI in mice. Immature DCs pulsed with homogen... | 18,825,159 |
Beam propagation factor of partially coherent flat-topped beams in a turbulent atmosphere. | The Wigner distribution function (WDF) has been used to study the beam propagation factor (M(2)-factor) for partially coherent flat-topped (PCFT) beams with circular symmetry in a turbulent atmosphere. Based on the extended Huygens-Fresnel principle and the definition of the WDF, an expression for the WDF of PCFT beams... | 18,825,195 |
Laser frequency stabilization and control through offset sideband locking to optical cavities. | We describe a class of techniques whereby a laser frequency can be stabilized to a fixed optical cavity resonance with an adjustable offset, providing a wide tuning range for the central frequency. These techniques require only minor modifications to the standard Pound-Drever-Hall locking techniques and have the advant... | 18,825,236 |
Measuring optical tunneling times using a Hong-Ou-Mandel interferometer. | We report a prediction for the delay measured in an optical tunneling experiment using Hong-Ou-Mandel (HOM) interference, taking into account the Goos-Hänchen shift generalized to frustrated total internal reflection situations. We precisely state assumptions under which the tunneling delay measured by an HOM interfero... | 18,825,239 |
Single-mode waveguide optical isolator based on direction-dependent cutoff frequency. | A single-mode-waveguide optical isolator based on propagation direction dependent cut-off frequency is proposed. The isolation bandwidth is the difference between the cut-off frequencies of the lowest forward and backward propagating modes. Perturbation theory is used for analyzing the correlation between the material ... | 18,825,259 |
Quantitative spectroscopic imaging for non-invasive early cancer detection. | We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construct... | 18,825,262 |
Optical snakes and ladders: dispersion and nonlinearity in microcoil resonators. | Microcoil resonators are a radical new geometry for high Q resonators with unique linear features. In this paper I briefly summarise their linear properties before extending the analysis to nonlinear interactions in microcoil resonators. As expected such nonlinear resonators are bistable and exhibit hysteresis. Finally... | 18,825,264 |
Plastinated tissue samples as three-dimensional models for optical instrument characterization. | Histology of biological specimens is largely limited to investigating two-dimensional structure because of the sectioning required to produce optically thin samples for conventional microscopy. With the advent of three-dimensional optical imaging technologies such as optical coherence tomography (OCT), diffuse optical ... | 18,825,267 |
Significant associations of stearoyl-CoA desaturase (SCD1) gene with fat deposition and composition in skeletal muscle. | Gene expression studies in humans and animals have shown that elevated stearoyl-CoA desaturase (SCD1) activity is associated with increased fat accumulation and monounsaturation of saturated fatty acids in skeletal muscle. However, results of the two reported association studies in humans are inconsistent. In the prese... | 18,825,276 |
Coadsorbed H and CO interaction on platinum. | The behavior of hydrogen near a platinum-surface-adsorbed carbon monoxide molecule is described using a potential energy term constructed from density functional theory. A clear nonattractive interaction of hydrogen with CO is confirmed, most notably with oxygen, which retains its strong H-repulsive traits in the Pt-bo... | 18,825,293 |
[Systemic therapy of metastasizing renal cell carcinoma]. | Once surgical options have been exhausted, systemic therapy is indicated for metastasizing renal cell carcinoma. Until recently this was carried out using mainly immunotherapeutic concepts with unsatisfactory results. Since the majority of clear cell renal cell carcinomas are well vascularised, angiogenetic inhibition ... | 18,825,295 |
High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. | Vitamin K and D deficiency and decreased bone mineral density (BMD) were highly prevalent in patients with inflammatory bowel disease (IBD), especially Crohn's disease (CD). Dietary intakes of these vitamins, however, were above the Japanese adequate intakes in IBD patients, suggesting that malabsorption is the basis f... | 18,825,300 |
Peripheral mechanisms I: plasticity of peripheral pathways. | Cough plays a vital role in protecting the lower airways from inhaled irritants, pollutants, and infectious agents. The cough reflex exhibits remarkable plasticity, such that in the context of infectious or inflammatory respiratory diseases such as asthma, chronic bronchitis, and idiopathic pulmonary fibrosis the cough... | 18,825,339 |
Central mechanisms II: pharmacology of brainstem pathways. | Following systemic administration, centrally acting antitussive drugs are generally assumed to act in the brainstem to inhibit cough. However, recent work in humans has raised the possibility of suprapontine sites of action for cough suppressants. For drugs that may act in the brainstem, the specific locations, types o... | 18,825,342 |
Dissection of the oligogenic resistance to Cucumber mosaic virus in the melon accession PI 161375. | Resistance to Cucumber mosaic virus (CMV) in the exotic melon accession PI 161375, cultivar "Sonwang Charmi" (SC) had previously been described as oligogenic, recessive and quantitative, with a major QTL residing in linkage group XII (LGXII). We have used a collection of near isogenic lines (NILs) with introgressions o... | 18,825,359 |
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study. | Serotonergic (SSRI) and noradrenergic (NRI) antidepressants modulate biases in emotional processing such that perceptual bias is shifted away from negative and towards positive emotional material. However, the effects of serotonergic and noradrenergic modulation on the temporal course (occurring in milliseconds) of emo... | 18,825,371 |
Serial (1)H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia. | The physiological mechanisms of deep brain stimulation (DBS) are not completely clear. Our understanding of them may be facilitated with the use of proton magnetic resonance spectroscopy ((1)H-MRS). Serial (1)H-MRS of both thalami was performed during the course of DBS of bilateral globus pallidus internus in a patient... | 18,825,378 |
[Rehabilitation and outpatient physiotherapy in rheumatic disease patients. Results of cross-sectional studies of patients with rheumatoid arthritis or ankylosing spondylitis and rheumatologists]. | Rehabilitation and outpatient physiotherapy were investigated from the perspectives of patients suffering from rheumatoid arthritis (RA) or ankylosing spondylitis (AS) and of rheumatologists. In 2007, 204 outpatients with RA and 47 with AS at the Arthritis Center in Halle, Germany, and 117 rheumatologists from all over... | 18,825,393 |
Four consecutive multicenter phase II trials of adjuvant chemoradiation in patients with completely resected high-risk gastric cancer: the experience of the German AIO/ARO/CAO group. | Feasibility and efficacy of four different adjuvant radiochemotherapy regimens in patients with completely resected gastric cancer were evaluated in consecutive cooperative phase II trials using different 5-fluorouracil (5-FU)-based combination chemotherapies (CTX) and 5-FU-enhanced radiotherapy. Between 2000 and 2005,... | 18,825,411 |
Dynamics of alpha helix formation in the CSAW model. | We study the folding dynamics of polyalanine (Ala20), a protein fragment with 20 residues whose native state is a single alpha helix. We use the CSAW model (conditioned self-avoiding walk), which treats the protein molecule as a chain in Brownian motion, with interactions that include hydrophobic force and internal hyd... | 18,825,424 |
Assessment of organochlorine pesticide levels in Manadas Creek, an urban tributary of the Rio Grande in Laredo, Texas. | The Rio Grande is the natural boundary between the United States and Mexico from El Paso, Texas, to Brownsville, Texas. It supports about 12 million people on both sides of the border for municipal, agricultural, industrial, and recreational uses. The rapid population and economic growth along the border region has led... | 18,825,443 |
Retraction transaminitis: an inevitable but benign complication of laparoscopic fundoplication. | Transient transaminitis has been identified following laparoscopic abdominal surgery. However, the importance of posture, duration of surgery, and mechanical retraction in its etiology remain unclear. Liver function was assessed preoperatively then at 8, 24, 48 and 72 h following laparoscopic surgery including the foll... | 18,825,455 |
A one-wire method for anatomic reduction of tibial fractures with Ilizarov frame. | Traditional external fixator techniques do not always correct minor residual malalignment. We asked whether using a one-wire method that corrects minor malalignment with an olive traction wire placed in the plane of the deformity allowed (1) uniform healing, (2) proper alignment, and (3) adequate reduction of fracture ... | 18,825,469 |
Darbepoetin in the control of cancer-related anaemia. | A group of 62 patients with different advanced cancers and with an anaemic condition were treated with a short course of darbepoetin administered on two different schedules as supportive therapy. The response rates (i.e. a haemoglobin increase of at least 1 g in 1 month) were 45.7% overall, 52.3% with weekly administra... | 18,825,479 |
Genetic and phenotypic characterization of a low-pathogenicity avian influenza H11N9 virus. | An H11N9 low-pathogenicity avian influenza virus, A/duck/WA/663/97, was isolated from a sick Mandarin duck kept in an outdoor bird exhibit. Genetic and phenotypic characterization of the virus suggested that it originated from free-flying birds, a concept supported by genetic similarity with waterfowl isolates from the... | 18,825,481 |
Cold co-extraction of hemagglutinin and matrix M1 protein from influenza virus A by a combination of non-ionic detergents allows for visualization of the raft-like nature of the virus envelope. | Membrane solubilization with a mixture of cold non-ionic detergents has been applied to isolate detergent-resistant membranes from intact virus A lipid bilayer. Association of the viral envelope glycoproteins and M1 into a raft lipid-protein complex was verified via detergent insolubility experiments, and the M1:HA sto... | 18,825,482 |
An examination of dedifferentiation in cognition among African-American older adults. | The structure and organization of cognitive abilities has been examined across the life span. The current analysis had three specific aims: (1) test the factor structure of a broad cognitive ability battery across three age groups; (2) examine differences in the pattern of factor covariation across age groups; and (3) ... | 18,825,494 |
What, exactly, is cladistics? Re-writing the history of systematics and biogeography. | The development of comparative biology (systematics) has been of interest to philosophers and historians. Particular attention has been placed on the 'war' of the 1970s and 1980s, the apparent dispute among those who preferred this or that methodology. In this contribution we examine the history of comparative biology ... | 18,825,502 |
Comparison of knowledge and accessibility to information sources of HIV/AIDS between blind and sighted populations in Nigeria. | The aim of this study was to compare the HIV/AIDS knowledge and accessibility to HIV/AIDS information between blind and sighted individuals in Nigeria. A cross-sectional survey was undertaken among rural and urban blind (57) and sighted (62) adolescents in 2006. A structured questionnaire was used to collect data about... | 18,825,516 |
In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048. | Trichlorfon is a specific inhibitor of cholinesterases. It was typically used as an insecticide; however, trichlorfon was described as useful for symptomatic treatment of Alzheimer's disease some years ago. The presented study is aimed at reactivation of trichlorfon-inhibited butyrylcholinesterase since this enzyme pla... | 18,825,528 |
Synthesis and biological activities of new hydrazide derivatives. | The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, (1)H-NMR, FAB(+)-MS spectral data. Their biological activity against various bacteria, fungi species, and Mycobacterium tuberculosis was investigat... | 18,825,530 |
Design, synthesis, characterization and in vitro antimicrobial evaluation of 4,6-diaryl-4,5-dihydro-2-phenyl-2H-indazol-3-ols. | New 4,6-diaryl-4,5-dihydro-2-phenyl-2H-indazol-3-ols 25-32 were designed, synthesized and in vitro microbially evaluated using clinically isolated bacterial strains viz Staphylococcus aureus, beta-Heamolytic streptococcus, Vibreo cholerae, Salmonella typhii, Shigella felxneri and fungal strains viz Aspergillus flavus, ... | 18,825,556 |
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