title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants. | We provide a protocol that describes an explant system that allows the dynamics of motor axons to be imaged. This method is based on nerve-muscle explants prepared from the triangularis sterni muscle of mice, a thin muscle that covers the inside of the thorax. These explants, which can be maintained alive for several h... | 18,833,201 |
Nanoscale magnetic sensing with an individual electronic spin in diamond. | Detection of weak magnetic fields with nanoscale spatial resolution is an outstanding problem in the biological and physical sciences. For example, at a distance of 10 nm, the spin of a single electron produces a magnetic field of about 1 muT, and the corresponding field from a single proton is a few nanoteslas. A sens... | 18,833,275 |
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. | Cleavage of the amyloid precursor protein (APP) is a crucial event in Alzheimer disease pathogenesis that creates the amyloid-beta peptide (Abeta) and liberates the carboxy-terminal APP intracellular domain (AICD) into the cytosol. The interaction of the APP C terminus with the adaptor protein Fe65 mediates APP traffic... | 18,833,287 |
ATM and Chk2 kinase target the p53 cofactor Strap. | The p53 cofactor Strap (stress responsive activator of p300) is directly targeted by the DNA damage signalling pathway where phosphorylation by ATM (ataxia telangiectasia mutated) kinase facilitates nuclear accumulation. Here, we show that Strap regulation reflects the coordinated interplay between different DNA damage... | 18,833,288 |
Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase. | In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA--U3, U14 and snR30--whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the pre-ribosome association to all 75 yeast snoRNAs in strains dep... | 18,833,290 |
Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. | The genetic basis of the development and variation of adult form of vertebrates is not well understood. To address this problem, we performed a mutant screen to identify genes essential for the formation of adult skeletal structures of the zebrafish. Here, we describe the phenotypic and molecular characterization of a ... | 18,833,299 |
Electromyography of 3 scapular muscles: a comparative analysis of the cuff link device and a standard push-up. | The Cuff Link is a closed kinetic chain rehabilitation apparatus for the upper extremity. Limited research has established its effectiveness to elicit muscle activation of the scapular muscles. To determine if scapular muscle activation differs in response to 2 upper extremity closed kinetic chain exercises: Cuff Link ... | 18,833,308 |
Reliability limits of the modified Thomas test for assessing rectus femoris muscle flexibility about the knee joint. | The modified Thomas test is commonly used in the clinical setting to assess flexibility about the thigh region. To evaluate the clinical reliability of the modified Thomas test for evaluating the flexibility of the rectus femoris muscle about the knee joint. Descriptive laboratory study using a test-retest design. Inst... | 18,833,309 |
Distractor inhibition predicts individual differences in the attentional blink. | The attentional blink (AB) refers to humans' impaired ability to detect the second of two targets (T2) in a rapid serial visual presentation (RSVP) stream of distractors if it appears within 200-600 ms of the first target (T1). Here we examined whether humans' ability to inhibit distractors in the RSVP stream is a key ... | 18,833,325 |
[The impact of oral health on the quality of life of HIV infected children: a literature review]. | The search for improvement of the health of systemically compromised patients and for a better knowledge about the impact of diseases on their lives has brought great interest for health-related quality of life, mainly in children with chronic diseases. The quality of life related to oral health is thus relevant, not o... | 18,833,356 |
A systematic review and meta-analysis of interventions used to reduce exposure to house dust and their effect on the development and severity of asthma. | We assessed whether any household dust reduction intervention has the effect of increasing or decreasing the development or severity of atopic disease. Electronic searches on household intervention and atopic disease were conducted in 2007 in EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials. We i... | 18,833,368 |
Alcohol consumption among victims of external causes in a university general hospital. | To estimate frequency of alcohol consumption among victims of external causes cared for in a hospital. Study performed with victims cared for in a university general hospital in the city of Uberlândia (Southeastern Brazil), between February and August 2004. Blood alcohol content was determined from 85 patients in the e... | 18,833,382 |
[Risk factors for falls in the elderly: systematic review]. | To systematize results of prospective cohort studies on multiple risk factors for falls in the elderly and to assess their methodological quality. Systematic review of epidemiological studies from Medline, SciELO and Lilacs database. We included prospective cohort studies with samples of more than 100 subjects of both ... | 18,833,393 |
HCV virological response during treatment of chronic hepatitis C is associated with liver histological improvement in patients with HCV/HIV co-infection. | Liver histological improvement after treatment for chronic hepatitis C in patients co-infected with human immunodeficiency virus-1 (HIV-1) has been described. Paired liver biopsies in twenty six HCV/HIV co-infected patients were compared to determine factors possibly associated with histological improvement. The patien... | 18,833,400 |
Primary sternal osteomyelitis caused by Nocardia nova: case report and literature review. | A 51 year old woman without significant past medical history or risk factors for Nocardia infection developed primary Nocardia nova sternal osteomyelitis with mediastinal abscess, diagnosed with open biopsy. She required prolonged antibiotic therapy and had a favorable outcome. Primary sternal osteomyelitis develops in... | 18,833,413 |
Cerebellum and psychiatric disorders. | The objective of this update article is to report structural and functional neuroimaging studies exploring the potential role of cerebellum in the pathophysiology of psychiatric disorders. A non-systematic literature review was conducted by means of Medline using the following terms as a parameter: "cerebellum", "cereb... | 18,833,430 |
Does directly observed treatment ("DOTS") contribute to tuberculosis treatment compliance? | This is a qualitative study performed in the theoretical framework of the Theory of Social Determination of the Health-Disease process and the concept of Compliance. The goal was to analyze meanings of DOTS in compliance with tuberculosis treatment, according to healthcare professionals of the Technical Healthcare Supe... | 18,833,445 |
Validation of the ratio scale of the differents types of pain. | The main aim was to validate the ratio scale derived from the non-metric continuum of the intensity of the different types of pain using cross-modality matching. Magnitude estimation method and cross-modality matching were used with perceived line lengths. The study was formed by 30 outpatients from various specialty c... | 18,833,454 |
Relations between nursing data collection, diagnoses and prescriptions for adult patients at an intensive care unit. | This descriptive, retrospective study aimed to analyze the relation between nursing data collection, diagnoses and prescriptions for 26 adult patients who were hospitalized at the intense care unit of a large teaching hospital for at least 24 hours. Through the analysis of medical records, 135 diagnoses and 421 nursing... | 18,833,451 |
Otolaryngologists and orbital pseudotumor: a case report. | Orbital pseudotumor (idiopathic orbital inflammation) is the third most common orbital disease, accounting for 5 to 6% of orbital disorders. It often presents in a manner very similar to inflammatory or neoplastic sinus disease. In addition, sinus disease is often a cause of orbital pseudotumor, although the etiology o... | 18,833,526 |
Squamous cell carcinoma of the buccal mucosa: a retrospective analysis of 22 cases. | We examined our institution's experience with 22 cases of previously untreated buccal squamous cell carcinoma via a retrospective chart review. Eleven of these patients had been treated with a combination of surgical excision and postoperative radiation therapy, 8 patients with surgical excision alone, and 3 patients w... | 18,833,538 |
Nanostructure formation enhances the activity of LPS-neutralizing peptides. | Peptides that interact with lipopolysaccharide (LPS) can provide the basis for the development of new antisepsis agents. In this work, several LPS-neutralizing acyl peptides derived from LALF, BPI, and SAP were prepared, structurally characterized, and biologically evaluated. In all cases, peptides with long acyl chain... | 18,833,552 |
Free flap failure secondary to dual thrombophilia. | Much has been learned over the past several decades regarding thrombophilic conditions. Thrombotic complications, such as deep venous thrombosis, pulmonary embolus, myocardial infarction, and stroke, are sometimes attributed to a diagnosable thrombophilia. Less has been written with regard to their effect on reconstruc... | 18,833,574 |
Emotional burden in caregivers of patients with obsessive-compulsive disorder. | The objective of this study was to evaluate the emotional burden, psychological morbidity, and level of family accommodation in caregivers of obsessive-compulsive disorder (OCD) patients, according to sociodemographic and clinical factors. Fifty Brazilian DSM-IV OCD patients and their caregivers were evaluated using th... | 18,833,578 |
The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans. | Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene an... | 18,833,581 |
Decline in sex ratio at birth after Bam (Kerman Province, Southern Iran) earthquake. | On 26th December 2003, a severe earthquake hit the city of Bam in Kerman province, southern Iran. It destroyed around 90% of houses and at least 60% of the public buildings, and claimed the lives of more than 20,000 persons. To investigate whether acute stress caused by the Bam earthquake could alter the sex ratio at b... | 18,833,587 |
Medical therapies to extend survival in hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) is a serious malignancy with 21,000 new cases estimated for 2008. Several common diseases are associated with an increased risk of the development of HCC, including viral hepatitis, cirrhosis, and other chronic liver diseases. Most patients present with advanced disease, and therefore hav... | 18,833,600 |
Estimating HIV incidence in the United States from HIV/AIDS surveillance data and biomarker HIV test results. | The development of an human immunodeficiency virus (HIV) test that detects recent infection has enabled the U.S. Centers for Disease Control and Prevention (CDC) to estimate annual HIV incidence (number of new infections per year, not per person at risk) in the United States from data on new HIV and acquired immunodefi... | 18,833,636 |
The influences of ambient and body calcium on cadmium and zinc accumulation in Daphnia magna. | The dissolved uptake rate constant (k(u)), dietary assimilation efficiency (AE), and efflux rate constant (k(e)) of cadmium (Cd) and zinc (Zn) were quantified in a freshwater zooplankton Daphnia magna cultured at different ambient calcium (Ca) concentrations. The animals were first acclimated to different ambient Ca le... | 18,833,650 |
Using nitrous oxide and oxygen to control pain in primary care. | Improving pain control is an area where nurses have the clinical expertise to make a significant difference to the quality of patient care. The inhaled analgesic 50% nitrous oxide and 50% oxygen is ideal for use when undertaking short, potentially painful procedures as it is a safe and effective method of pain relief. ... | 18,833,717 |
Conservation of cytoplasmic organization in the cystidia of Suillus species. | Cystidia of Suillus americanus and S. granulatus (Boletales) were examined cytochemically and ultrastructurally with cells prepared by freeze substitution. We present the first study showing ultrastructural details and cytological functions of the cystidium to be conserved in two closely related species. The results ar... | 18,833,747 |
Light might regulate divergently depside and depsidone accumulation in the lichen Parmotrema hypotropum by affecting thallus temperature and water potential. | Depsides and depsidones are the most common secondary products uniquely produced in lichens by the fungal symbiont, and they accumulate on the outer surface of its hyphae. Their biological roles are subject to debate. Quantitatively the compounds typical of a given lichen can vary dramatically from thallus to thallus. ... | 18,833,750 |
The structure and histochemistry of sclerotia of Ophiocordyceps sinensis. | The structure and histochemistry of sclerotia of Ophiocordyceps sinensis (synonym: Cordyceps sinensis) are described. The remains of the caterpillar epidermis and sometimes setae of the caterpillar were attached to the pigmented layer that is external to the rind of the sclerotium. The outer aerial hyphae and hyphae of... | 18,833,754 |
Nonlinear stress analysis of titanium implants by finite element method. | With use of dental implants on the rise, there is also a tandem increase in the number of implant fracture reports. To the end of investigating the stress occurring in implants, elasticity and plasticity analyses were performed using the finite element method. The following results were obtained: (1) With one-piece typ... | 18,833,779 |
The conservation status and trends of raptors and owls in Europe. | To conserve biodiversity efficiently, an international framework is needed to ensure that national priorities take into account regional and global priorities. BirdLife International has published five comprehensive assessments of the global status of the world's birds and two evaluations of the status of Europe's bird... | 18,833,791 |
Application of the probabilistic approach to reporting breast fine needle aspiration in males. | To apply the probabilistic approach to a series offine needle aspiration (FNA) samples of male breast lesions and determine the accuracy and reproducibility of this method of reporting in men. All male breast surgical specimens with a preoperative breast FNA at our institution from 1994 to 2005 were identified. The FNA... | 18,833,813 |
Evaluation of brushing cytology in the diagnosis of Helicobacter pylori gastritis. | To evaluate clinical utility of rapid urease test (RUT), brash cytology and histology for detecting Helicobacter pylori. Brush cytology materials were obtained from the antrum of the stomach in 109 patients who suffered from dyspepsia and were candidates for endoscopy. RUT and histology with hematoxylin-eosin staining ... | 18,833,824 |
Shear bond strength of provisional restoration materials repaired with light-cured resins. | This study evaluated the repair bond strengths of light-cured resins to provisional restoration materials with different chemical compositions and polymerization techniques. Fifty discs (10 mm in diameter and 1.5 mm thick) were fabricated for each provisional resin base material, including a self-cured methacrylate (Al... | 18,833,857 |
The effects of tooth preparation cleansing protocols on the bond strength of self-adhesive resin luting cement to contaminated dentin. | This in vitro study evaluated the bond strength of a self-adhesive luting cement after using four different techniques to remove surface contamination on dentin. Extracted human molars were flattened to expose the dentin surface and prepared for full crown preparation. Acrylic temporary crowns were fabricated and place... | 18,833,862 |
In vitro bonding performance of self-etch adhesives: II--ultramorphological evaluation. | To study the interfacial ultra-morphology formed by "all-in-one" self-etch adhesives. Forty-nine extracted molars were assigned to one of five all-in-one adhesives: Adper Prompt L-Pop (AP, 3M ESPE); Clearfil S3 Bond (S3, Kuraray); G-Bond (GB, GC America); iBond (iB, Heraeus Kulzer) and Xeno IV (XE, Dentsply Caulk). Adp... | 18,833,860 |
Radiographic and ultrasonographic features of canine paraprostatic cysts. | Mineralization of paraprostatic cysts is reported to be uncommon. This retrospective study was performed to review the imaging findings of eight histologically confirmed canine paraprostatic cysts. Radiographic patterns of mineralization seen are described. Four of the eight dogs had mineralized cysts. Mineralization s... | 18,833,951 |
Effect of left vs. right recumbency on the vertebral heart score in normal dogs. | The effect of right vs. left recumbency on computation of the vertebral heart score (VHS) was assessed in 63 healthy dogs. The VHS was significantly higher in right lateral recumbency (9.8 +/- 0.6 vs. 9.5 +/- 0.8; P < 0.0004). Gender and dog size did not significantly influence VHS values while there was m orediffer... | 18,833,953 |
Imaging diagnosis--cervical spine chondroma in a dog. | An extradural chondroma originating in the cervical spine was diagnosed in an 8-year-old, intact male Chow-Chow that presented acute cervical pain and chronic right thoracic limb lameness. Myelographic images were within normal limits. With magnetic resonance (MR) imaging, an extradural mass was identified at the level... | 18,833,956 |
[Ketogenic diets and weight loss: basis and effectiveness]. | The international consensus is that carbohydrates are the basis of the food pyramid of a healthy diet. Today's specialists believe that the best way to lose weight is by cutting down on calories, essentialy in the form of fat. However, this paper will clarify that ketogenic diets are, from a physiological, biochemicale... | 18,833,988 |
Chemical composition and fatty acid profile of rhea (Rhea americana) meat. | The purpose of this work was to determine the proximate composition and fatty acid profiles of the Gastrocnemius pars interna intramuscular fat (IMF) of rhea (Rhea americana) thighs. The birds were bred in captivity, fed with balanced feed (Nutriavestruz Crescimento - Purina) and kept in a pen with grass ad lib. The bi... | 18,833,999 |
Treatment of skeletal class II malocclusion in adults: stepwise vs single-step advancement with the Herbst appliance. | To compare 2 groups of mature patients treated with the Herbst appliance and present a new protocol based on tissue responses to enhance skeletal response. Lateral cephalograms taken before and after treatment for 2 groups of patients--the first treated with the Herbst appliance with maximum jumping and the second with... | 18,834,006 |
The use of cone-beam computed tomography in an orthodontic department in between research and daily clinic. | A correct orthodontic diagnosis needs to be based on accurate images of the craniofacial region and is crucial for the development of a valid treatment plan. A cone-beam computed tomography (CBCT) scanner allows 3D imaging of the craniofacial complex. CBCT scanners represent a significant advantage in imaging capabilit... | 18,834,009 |
A comparative study of self-perceived public health competencies: practice teachers and qualifying SCPHNs. | There is evidence to suggest that population-focused public health nursing is more rhetoric than reality. This quantitative study compares the self-perceived public health competence of qualifying student specialist community public health nurses (SCPHNs) (n = 35) with those of the practice teachers (PTs) facilitating ... | 18,834,026 |
Developing clinically savvy nursing students: an evaluation of problem-based learning in an associate degree program. | Faculty in an associate degree nursing program at a community college in NewYork City noted that nursing students lacked critical analysis, problem-solving, and decision-making skills and the reflective ability essential to applying nursing knowledge in clinical situations. This study reports on the use of problem-base... | 18,834,057 |
FTIR identification of the nu4(sigmau) and nu6(piu) modes of linear GeC3Ge trapped in solid Ar. | GeC 3Ge was previously (1) produced by the dual laser ablation of germanium and carbon rods, and the nu 3(sigma u) carbon-carbon stretching fundamental was assigned at 1920.7 cm (-1). This paper presents results from new experiments that have enhanced the production of the molecule via laser ablation of a single sinter... | 18,834,086 |
Molecular structure and benzene ring deformation of three cyanobenzenes from gas-phase electron diffraction and quantum chemical calculations. | The molecular structures of cyanobenzene, p-dicyanobenzene, and 1,2,4,5-tetracyanobenzene have been accurately determined by gas-phase electron diffraction and ab initio/DFT MO calculations. The equilibrium structures of these molecules are planar, but their average geometries in the gaseous phase are nonplanar because... | 18,834,088 |
The simplest linear-carbon-chain growth by atomic-carbon addition and ring opening reactions. | The formation mechanism of linear-carbon-chain molecules, C n O ( n = 2 - 9), synthesized in the discharge of C 3O 2 has been investigated on the basis of detailed analyses of previously obtained FTMW spectroscopic data. The relative abundances of the C n O products determined from their rotational spectrum intensities... | 18,834,097 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical prediction was compared with the experimental activity data. Th... | 18,834,112 |
Synthesis of beta-, gamma-, and delta-lactams via Pd(II)-catalyzed C-H activation reactions. | Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams. | 18,834,119 |
Synthesis of 1,2- and 1,3-dicarboxylic acids via Pd(II)-catalyzed carboxylation of aryl and vinyl C-H bonds. | A Pd(II)-catalyzed reaction protocol for the direct carboxylation of benzoic and phenylacetic acid derivatives to form dicarboxylic acids has been developed. The reaction conditions are also applicable for the carboxylation of vinyl C-H bonds. The first C-H insertion Pd-aryl complex from carboxylic acids has been chara... | 18,834,125 |
Synthesis of substituted naphthalenes via a catalytic ring-expansion rearrangement. | A new methodology for the preparation of substituted naphthalenes starting from readily available indenones, organometal reagents, and trimethylsilyldiazomethane via a catalytic rearrangement process is described. Hindered biaryl naphthalenes, including triortho-substituted biaryls, can be accessed through our method. ... | 18,834,135 |
Determination of polycyclic aromatic hydrocarbons in drinking water samples by solid-phase nanoextraction and high-performance liquid chromatography. | A novel alternative is presented for the extraction and preconcentration of polycyclic aromatic hydrocarbons (PAH) from water samples. The new approachwhich we have named solid-phase nanoextraction (SPNE)takes advantage of the strong affinity that exists between PAH and gold nanoparticles. Carefully optimization of exp... | 18,834,147 |
Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites. | An LC-MS-NMR platform is demonstrated, which combines two innovations in microscale analysis, nanoSplitter LC-MS and microdroplet NMR, for the identification of unknown compounds found at low concentrations in complex sample matrixes as frequently encountered in metabolomics or natural products discovery. The nanoSplit... | 18,834,150 |
Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties. | Chitosan is a promising biomaterial with an attractive safety profile; however, its application potential for gene delivery is hampered by poor compatibility at physiological pH values. Here we have tailored the molecular architecture of chitosan to improve the functional properties and gene transfer efficacy of chitos... | 18,834,173 |
Structure of an accurate ab initio model of the aqueous Na+ ion at high temperatures. | The structure of an accurate ab initio model of aqueous sodium ion was calculated at two high temperature state points (573 K, 0.72 g/cm(3) and 723 K, 0.0098 g/cm(3)) by a two-step procedure. First, the structure of an approximate model (the TIP4-FQ model for water and Na-H2O interactions from Liu et al.) was calculate... | 18,834,190 |
Synthesis of hexagonal nickel hydroxide nanosheets by exfoliation of layered nickel hydroxide intercalated with dodecyl sulfate ions. | One-nanometer-thick nickel hydroxide nanosheets were prepared by exfoliation of layered nickel hydroxides intercalated with dodecyl sulfate (DS) ions. The shape of the nanosheets was hexagonal, as was that of the layered nickel hydroxides intercalated with DS ions. The nickel hydroxide nanosheets exhibited charge-disch... | 18,834,194 |
Hierarchical assembly of viral nanotemplates with encoded microparticles via nucleic acid hybridization. | We demonstrate hierarchical assembly of tobacco mosaic virus (TMV)-based nanotemplates with hydrogel-based encoded microparticles via nucleic acid hybridization. TMV nanotemplates possess a highly defined structure and a genetically engineered high density thiol functionality. The encoded microparticles are produced in... | 18,834,199 |
Comparison of quantitative immunofluorescence with conventional methods for HER2/neu testing with respect to response to trastuzumab therapy in metastatic breast cancer. | Selection for trastuzumab therapy depends on a companion diagnostic assessment of HER2 by either immunohistochemistry (IHC) for protein overexpression or fluorescence in situ hybridization (FISH) to detect gene amplification. Although many studies have compared IHC to FISH, few have compared the tests to the true gold ... | 18,834,223 |
Early wound healing following one-stage dental implant placement with and without antibiotic prophylaxis: a pilot study. | One-stage implant placement has clinically acceptable treatment outcomes. Among other advantages, it may allow investigation of early wound healing. The purpose of this pilot study was to determine whether peri-implant crevicular fluid (PICF) can be used to detect early changes around implants placed with one-stage sur... | 18,834,245 |
Effects of ultrasound on the proliferation and differentiation of cementoblast lineage cells. | The purpose of this study was to investigate the effects of low-intensity pulsed ultrasound (LIPUS) stimulation on the proliferation and differentiation of cementoblast lineage cells. An immortalized human periodontal ligament cell line (HPL) showing immature cementoblastic differentiation was used. Cultured HPL cells ... | 18,834,255 |
Clinical and histologic evaluation of an enamel matrix derivative combined with a biphasic calcium phosphate for the treatment of human intrabony periodontal defects. | The goal of this study was to evaluate clinically and histologically the healing of advanced intrabony defects following regenerative periodontal surgery with an enamel matrix derivative (EMD) combined with a new biphasic calcium phosphate (BCP). Ten subjects, each of them displaying advanced combined 1- and 2-wall int... | 18,834,256 |
Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival. | Antiangiogenic agents have recently shown impressive radiological responses in high-grade glioma. However, it is not clear if the responses are related to vascular changes or due to antitumoral effects. The authors report the mature results of a clinical study of bevacizumab-based treatment of recurrent high-grade glio... | 18,834,263 |
Interhemispheric transcallosal subchoroidal fornix-sparing craniotomy for total resection of colloid cysts of the third ventricle. | Endoscopic surgery has been reported to be more cost-effective and safer than open craniotomy for resection of colloid cysts, despite a 5-10% conversion rate to craniotomy, a 5% recurrence rate, a 5-10% ventricular shunting rate, a 5-10% epilepsy rate, and a 3-4 day hospital stay. In 1985, the authors developed a inter... | 18,834,265 |
Scoring the DSM-IV personality disorders using the Five-Factor Model: development and validation of normative scores for North American, French, and Dutch-Flemish samples. | Five-Factor Model (FFM) personality disorder (PD) counts have demonstrated significant convergent and discriminant validity with DSM-IV PD symptoms. However, these FFM PD counts are of limited clinical use without normative data because it is difficult to determine what a specific score means with regard to the relativ... | 18,834,293 |
Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial. | Comparable sustained virologic response (SVR) rates have been documented between Asian patients who received 24 weeks of pegylated interferon (IFN) plus ribavirin and white patients who received 48 weeks of combination therapy for hepatitis C virus genotype 1 (HCV-1) infection. Whether a 48-week course of combination t... | 18,834,319 |
Effect of Bupleuri Radix extracts on the toxicity of 5-fluorouracil in HepG2 hepatoma cells and normal human lymphocytes. | Despite the excellent chemotherapeutic effect of 5-fluorouracil, its cytotoxicity and genotoxicity in normal cells remain a major problem. We sought to assess whether Bupleuri Radix extract enhances 5-fluorouracil-induced cytotoxicity in HepG2 hepatoma cells, while protecting normal blood lymphocytes. Bupleuri Radix, u... | 18,834,353 |
Characterization of low-density lipoprotein cholesterol-lowering efficacy for atorvastatin in a population-based DNA biorepository. | The Marshfield Clinic Personalized Medicine Research Project (PMRP) represents a large population-based biobank located in central Wisconsin. To position the PMRP database for large-scale pharmacogenetic association studies in the context of lipid-lowering therapy, we constructed an electronic phenotyping algorithm to ... | 18,834,356 |
An examination of beta-cell function measures and their potential use for estimating beta-cell mass. | A characteristic and dominant feature of type 2 diabetes is a reduction in beta-cell function that is associated with a decrease in beta-cell volume. A decline in the first-phase insulin response following intravenous glucose administration can be demonstrated as the fasting glucose concentration increases. This respon... | 18,834,434 |
Pacemaker therapy for early and late sinus node dysfunction in orthotopic heart transplant recipients: a single-center experience. | Sinus node dysfunction (SND) is a well-known early complication of orthotopic heart transplantation (OHT). Its incidence over the lifetime of transplant recipients is less well characterized. The goal of this study was to determine the incidence and timing of SND treated with a permanent pacemaker in a large cohort of ... | 18,834,460 |
Effect of atrial lead position on atrial automatic capture verification. | Optimizing atrial automatic capture verification based on atrial-evoked response (AER) detection requires maximizing the signal artifact ratio (SAR), that is, AER to stimulation artifact (ART). This study evaluated the effect of bipolar atrial lead position on sensed AER, ART, and SAR. A custom-made external research s... | 18,834,462 |
Atrial and ventricular arryhthmogenic potential in Turner Syndrome. | P-wave dispersion (Pd), corrected P-wave dispersion (Pdc), QT-wave dispersion (QTd), and corrected QT-wave dispersion (QTdc) parameters were not assessed in Turner Syndrome (TS) before. The aim of this study is to investigate the cardiac arrhythmogenic potential in patients with TS. Thirty-one patients with TS and 30 h... | 18,834,465 |
The world survey of cardiac pacing and cardioverter-defibrillators: calendar year 2005 an International Cardiac Pacing and Electrophysiology Society (ICPES) project. | A worldwide cardiac pacing and implantable cardioverter-defibrillator (ICD) survey was undertaken for calendar year 2005 and compared to a similar survey conducted in 2001. There were contributions from 43 countries: 16 from Europe, 13 from the Asia Pacific region, four from the Middle East and Africa, and 10 from the ... | 18,834,475 |
Concept recognition for extracting protein interaction relations from biomedical text. | Reliable information extraction applications have been a long sought goal of the biomedical text mining community, a goal that if reached would provide valuable tools to benchside biologists in their increasingly difficult task of assimilating the knowledge contained in the biomedical literature. We present an integrat... | 18,834,500 |
Simultaneous ipsilateral proximal interphalangeal and metacarpophalangeal dislocation of the fifth phalanx: A case report. | There is no case of simultaneous ipsilateral proximal interphalangeal and metacarpophalangeal dislocation of a finger in the literature. A 61 years old male patient sustained an ipsilateral dorsal dislocation of the PIP joint of his fifth finger and dorsal dislocation of the metacarpophalangeal joint. Closed reduction ... | 18,834,501 |
The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. | GPR125 belongs to the family of Adhesion G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a Drosophila sequence, DmCG15744, which shares a common ancestor with the entire Group III of Adhesion GPCRs, and also contains Ig, LRR and HBD domains which wer... | 18,834,514 |
Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability. | Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer. To further understand Herceptin resistance mechanisms at the molecular level, we used comparative proteome approaches to analyze two human breast cancer cell l... | 18,834,540 |
PhySIC_IST: cleaning source trees to infer more informative supertrees. | Supertree methods combine phylogenies with overlapping sets of taxa into a larger one. Topological conflicts frequently arise among source trees for methodological or biological reasons, such as long branch attraction, lateral gene transfers, gene duplication/loss or deep gene coalescence. When topological conflicts oc... | 18,834,542 |
Pol II promoter prediction using characteristic 4-mer motifs: a machine learning approach. | Eukaryotic promoter prediction using computational analysis techniques is one of the most difficult jobs in computational genomics that is essential for constructing and understanding genetic regulatory networks. The increased availability of sequence data for various eukaryotic organisms in recent years has necessitat... | 18,834,544 |
Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats. | Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications. The structural and pharmacological similarity of pseudoephedrine to amphetamine has led to evaluation of its psychomotor stimulant properties within the central nervous... | 18,834,549 |
Mechanisms of gene-environment interactions in depression: evidence that genes potentiate multiple sources of adversity. | Previous work suggests that daily life stress-sensitivity may be an intermediary phenotype associated with both genetic risk for depression and developmental stress exposures. In the current analysis we hypothesized that genetic risk for depression and three environmental exposures over the course of development [prena... | 18,834,553 |
Religious service attendance and spiritual well-being are differentially associated with risk of major depression. | The complex relationships between religiosity, spirituality and the risk of DSM-IV depression are not well understood. We investigated the independent influence of religious service attendance and two dimensions of spiritual well-being (religious and existential) on the lifetime risk of major depression. Data came from... | 18,834,554 |
[A case of uterine carcinosarcoma]. | Uterine carcinosarcoma is a highly aggressive neoplasm with tendency to early recurrence and/or metastasis. The neoplasia has both epithelial and stromal malignant components. Clinically, it is characterized by a postmenopausal metrorrhagia, associated sometimes with abdominal pain. The Authors describe a case of carci... | 18,834,571 |
Nanowear studies in reversibly switchable polystyrene-poly(acrylic acid) mixed brushes. | Wear studies were performed on polystyrene (PS)-poly(acrylic acid) (PAA) mixed polymer brushes and corresponding monobrushes in a dried state. The aim was to study the wear mechanism in polymer brush surfaces as well as to investigate the effect of switching of PS + PAA binary brush surfaces (on treatment with the sele... | 18,834,596 |
Early diagenetic processes aspects controlling the mobility of dissolved trace metals in three riverine sediment columns. | The behaviour of Mn, Fe, Co, Zn, Cd, Pb and Ni has been studied during early diagenesis in three different riverine sediments (Spierre, Lys and Sheldt). For that purpose (1) pore waters were extracted from sediment cores by centrifugation under nitrogen and further analyzed for the determination of total dissolved meta... | 18,834,616 |
PCL microspheres based functional scaffolds by bottom-up approach with predefined microstructural properties and release profiles. | Advanced tissue engineering approaches rely upon the employment of biomaterials that integrate biodegradable scaffolds with growth factor delivery devices to better guide cellular activities and enhance tissue neogenesis. Along these lines, here we proposed a bottom-up approach for the realization of bioactive scaffold... | 18,834,628 |
Immobilization of bacteriophage Qbeta on metal-derivatized surfaces via polyvalent display of hexahistidine tags. | Metal-binding peptide motifs are widely used for protein purification, catalysis, and metal-mediated self assembly in the construction of novel materials and multivalent light harvesting complexes. Herein we describe hexahistidine sequences incorporated into the virus-like particle derived from bacteriophage Qbeta via ... | 18,834,633 |
The role of Malassezia in atopic dermatitis affecting the head and neck of adults. | Atopic dermatitis is a common chronic skin condition. A subset of patients with head and neck dermatitis may have a reaction to Malassezia flora fueling their disease. Although there are no documented differences in Malassezia species colonization, patients with head and neck atopic dermatitis are more likely to have p... | 18,834,647 |
Preparation and photocatalytic activity of nanoglued Sn-doped TiO2. | In this paper, Sn-doped TiO(2) photocatalyst was prepared and immobilized on a glass substrate using an about-to-gel SiO(2) sol as a nanoglue. The characterization of the Sn-doped TiO(2) by XRD showed that 5% Sn content is formed by anatase and rutile crystallites. Characterization of the nanoglued photocatalyst by the... | 18,834,665 |
Low-dose palliative radiotherapy for cutaneous B- and T-cell lymphomas. | To determine the efficacy of low-dose palliative radiotherapy for both low-grade malignant cutaneous B-cell lymphomas (CBCLs) and cutaneous T-cell lymphomas (mycosis fungoides). A total of 18 patients with low-grade CBCL (10 primary cutaneous marginal zone B-cell and 8 primary cutaneous follicle center lymphomas) with ... | 18,834,672 |
Cemented hip revision surgery in severe acetabular defects using a semirigid acetabular reinforcement ring--a 5- to 25-year follow-up study. | Between 1978 and 1998, a total of 38 consecutive acetabular component revisions were performed in 38 patients. Average age was 67 years, and 87% of patients had severe uncontained segmental acetabular defects of more than 50%. We describe the operative technique of acetabular component revisions performed with bone gra... | 18,834,699 |
The Internet is valid and reliable for child-report: an example using the Activities Scale for Kids (ASK) and the Pediatric Quality of Life Inventory (PedsQL). | This study tested the impact of web administration on well-established measures of children's physical function and quality of life. Participants were recruited from clinics at six hospitals. They completed the Activities Scale for Kids (ASK) and the Pediatric Quality of Life Inventory (PedsQL) questionnaires twice, in... | 18,834,710 |
AHRQ series paper 1: comparing medical interventions: AHRQ and the effective health-care program. | In 2005, the Agency for Healthcare Research and Quality established the Effective Health Care (EHC) Program. The EHC Program aims to provide understandable and actionable information for patients, clinicians, and policy makers. The Evidence-based Practice Centers are one of the cornerstones of the EHC Program. Three ke... | 18,834,715 |
D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes. | Certain D2 dopamine receptor Taq 1A genotypes (A1A1, A1A2) have been associated with obesity and substance abuse. We hypothesized that their presence would be associated with reduced efficacy of dietary interventions in individuals with type 2 diabetes. In the course of a randomized clinical trial in an outpatient rese... | 18,834,717 |
Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia. | The objective was to evaluate the effect of iron supplementation for 6 mo on blood lead (PbB) concentration in populations of premenopausal (PRE-M) and postmenopausal (POST-M) Korean women. We conducted a community intervention trial in Asan, Republic of Korea. Of the 137 enrolled women with hemoglobin (Hb) levels lowe... | 18,834,721 |
A large outbreak of Trichophyton tonsurans among health care workers in a pediatric hospital. | Although Trichophyton tonsurans remains a major cause of dermataophytoses in US children, nosocomial spread may go unrecognized in health care settings. We describe a staff outbreak of T tonsurans infection among health care workers in a freestanding pediatric hospital. Epidemiologic evaluation (retrospective and prosp... | 18,834,726 |
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