title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Effect of endothelium-specific insulin resistance on endothelial function in vivo. | Insulin resistance is an independent risk factor for the development of cardiovascular atherosclerosis. A key step in the development of atherosclerosis is endothelial dysfunction, manifest by a reduction in bioactivity of nitric oxide (NO). Insulin resistance is associated with endothelial dysfunction; however, the me... | 18,835,939 |
First experience with real-time three-dimensional transoesophageal echocardiography-guided transseptal in patients undergoing atrial fibrillation ablation. | Transseptal (TS) puncture during atrial fibrillation (AF) ablation is a relatively safe procedure in experienced hands. However, major and minor complications cannot be completely ruled out. Real-time three-dimensional transeosophageal echocardiography (RT 3D TEE) is a novel imaging technology that permits direct visua... | 18,835,940 |
International tables of glycemic index and glycemic load values: 2008. | To systematically tabulate published and unpublished sources of reliable glycemic index (GI) values. A literature search identified 205 articles published between 1981 and 2007. Unpublished data were also included where the data quality could be verified. The data were separated into two lists: the first representing m... | 18,835,944 |
Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry. | Type 2 diabetes is the leading cause of end-stage renal disease worldwide. Aside from hyperglycemia and hypertension, other metabolic factors may determine renal outcome. We examined risk associations of metabolic syndrome with new onset of chronic kidney disease (CKD) in 5,829 Chinese patients with type 2 diabetes enr... | 18,835,954 |
Prediabetic and diabetic in vivo modification of circulating low-density lipoprotein attenuates its stimulatory effect on adrenal aldosterone and cortisol secretion. | Modification of low-density lipoprotein (LDL) and abnormal aldosterone and cortisol metabolism have been implicated in the pathogenesis of type 2 diabetes (DM2) and diabetic vascular disease. Since LDL serves as a major cholesterol source for adrenal steroidogenesis, we investigated whether LDL modification in prediabe... | 18,835,979 |
A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: properties of a rare actinobacterial TreT. | Trehalose is the primary organic solute in Rubrobacter xylanophilus under all conditions tested, including those for optimal growth. We detected genes of four different pathways for trehalose synthesis in the genome of this organism, namely, the trehalose-6-phosphate synthase (Tps)/trehalose-6-phosphate phosphatase (Tp... | 18,835,983 |
Genetic analysis of the Enterococcus vancomycin resistance conjugative plasmid pHTbeta: identification of the region involved in cell aggregation and traB, a key regulator gene for plasmid transfer and cell aggregation. | The Enterococcus plasmid pHTbeta (63.7 kbp) is a pheromone-independent, highly conjugative pMG1-like plasmid that carries a Tn1546-like transposon encoding vancomycin resistance. The transfer-related regions (Tra I, Tra II, and Tra III) containing oriT and a putative nickase gene (traI) have previously been identified ... | 18,835,991 |
Evidence for growth of enterococci in municipal oxidation ponds, obtained using antibiotic resistance analysis. | The Christchurch wastewater treatment plant uses a series of six oxidation ponds to reduce the bacterial load of treated effluent before it is discharged into the local estuary. To ensure that this discharge does not adversely affect water quality in the receiving environment, local regulations specify maximum levels i... | 18,836,001 |
Quantification and genotyping of torque teno virus at a wastewater treatment plant in Japan. | Torque teno virus (TTV) DNA was quantitatively detected in influent and effluent samples collected from a wastewater treatment plant in Japan, with the highest concentration being 4.8 x 10(4) copies/liter. Genogroup-specific nested PCR demonstrated that TTV of genogroup 3 was the most abundant in wastewater among the f... | 18,836,012 |
HtrA is essential for efficient secretion of recombinant proteins by Lactococcus lactis. | HtrA is a unique protease on the extracellular surface of Lactococcus lactis. It is known to take part in the proteolysis of many secreted recombinant proteins, and the mutation of htrA can lead to the complete stabilization of recombinant proteins. In this work, we have shown that htrA mutation also leads to significa... | 18,836,019 |
Haplotype sorting using human fosmid clone end-sequence pairs. | An important goal of human genetics and genomics is to understand the complete spectrum of genetic variation across a specific human haplotype. By combining information from a dense SNP map with fosmid end-sequence pairs (ESPs) aligned to the human genome reference sequence, we have developed a simple method to resolve... | 18,836,033 |
Disability and risk of non-fatal residential injuries among adults. | Many unintentional injuries occur in the home, but little research has considered the specific vulnerability of people with disabilities. Cross-sectional study examining nationally representative data from the 2004-2006 National Health Interview Surveys. Adults aged 18 and older who reported having an unintentional, no... | 18,836,046 |
Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. | Polycystin-2 (PC2), the gene product of one of two genes mutated in dominant polycystic kidney disease, is a member of the transient receptor potential cation channel family and can function as intracellular calcium (Ca(2+)) release channel. We performed a yeast two-hybrid screen by using the NH(2) terminus of PC2 and ... | 18,836,075 |
Rituximab monotherapy for primary cutaneous B-cell lymphoma: response and follow-up in 16 patients. | We have carried out a retrospective analysis to evaluate the therapeutic value of the anti-CD20 antibody rituximab in 16 consecutive patients with primary cutaneous CD20+ B-cell lymphomas. Sixteen patients (4 females, 12 males) with a median age of 54 years received systemic therapy with rituximab 375 mg/m(2) once week... | 18,836,086 |
A multifactorial strategy of pain management is associated with less pain in scheduled vaccination of children. A study realized by family practitioners in 239 children aged 4-12 years old. | The multiplicity of vaccine injections during childhood leads to iterative painful and stressful experiences which may lead in turn to anticipated pain and then possibly to a true needle phobia. We aimed at evaluating a multifactorial strategy of pain management combining pharmacological and non-pharmacological approac... | 18,836,092 |
UV-inducible base excision repair of oxidative damaged DNA in human cells. | Methylene blue (MB) acts as a photosensitizer and after excitation by visible light (VL) produces reactive oxygen species that result in oxidatively damaged DNA. (MB + VL) produces predominantly 8-hydroxyguanine as well as other single base modifications in DNA that are repaired by base excision repair (BER). We have u... | 18,836,099 |
A 'Regularly Irregular' tachycardia: what is the diagnosis? | We report the case of a 46-year-old female presented to the emergency room with sustained palpitations. Her ECG showed a narrow QRS regularly irregular tachycardia. This tachycardia was immediately terminated by a single dose of adenosine, and sinus rhythm was restored. Diagnosis of atrial tachycardia, orthodromic reci... | 18,836,153 |
Regulation of biomechanical signals by NF-kappaB transcription factors in chondrocytes. | Physical therapies and exercise are beneficial not only for physiological recovery in inflamed or injured joints, but also for promoting a homeostatic equilibrium in healthy joints. Human joints provide the pivot points and physiological hinges essential for ambulation and movement to the body, and it is this mobility ... | 18,836,228 |
Mechanical regulation of proteoglycan synthesis in normal and osteoarthritic human articular chondrocytes--roles for alpha5 and alphaVbeta5 integrins. | The importance of biomechanical forces in regulating normal chondrocyte metabolism is well established and the mechanisms whereby mechanical forces are transduced into biochemical responses by chondrocytes are beginning to be understood. Previous studies have indicated that cyclical mechanical stimulation induces incre... | 18,836,230 |
Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. | Obesity is one of the most significant, and potentially most preventable, risk factors for the development of osteoarthritis, and numerous studies have shown a strong association between body mass index and osteoarthritis of the hip, knee, foot and hand. However, the mechanism(s) by which obesity contributes to the ons... | 18,836,239 |
Modulatory effect of rhein on IL-1alpha-induced responses in human chondrocytes: a comparative study between antibody microarrays and specific ELISAs. | The present work aimed to take advantage of the screening capacity of protein arrays to search for additional targets of rhein in interleukin (IL)-1-stimulated chondrocytes. Primary cultures of chondrocytes from osteoarthritic (OA) patients were stimulated for 24 and 48 h with 1 ng/ml of IL-1alpha, in the presence or a... | 18,836,244 |
Chondroitin sulphate-mediated fusion of brain neural folds in rat embryos. | Previous studies have demonstrated that during neural fold fusion in different species, an apical extracellular material rich in glycoconjugates is involved. However, the composition and the biological role of this material remain undetermined. In this paper, we show that this extracellular matrix in rat increases nota... | 18,836,253 |
Functional tradeoffs in axonal scaling: implications for brain function. | Like electrical wires, axons carry signals from place to place. However, unlike wires, because of the electrochemical mechanisms for generating and propagating action potentials, the performance of an axon is strongly linked to the costs of its construction and operation. As a consequence, the architecture of brain wir... | 18,836,261 |
Oxaliplatin/5-fluorouracil/leucovorin (FOLFOX4) regimen as an adjuvant chemotherapy in the treatment of advanced jejunal adenocarcinoma: a report of 2 cases. | To present our clinical experience of 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen administered as an adjuvant chemotherapy to 2 patients with advanced jejunal adenocarcinoma. A 55-year-old woman presented with recurrent upper abdominal pain, nausea and vomiting. A small bowel series as well as the abdominal... | 18,836,281 |
PTEN signaling pathways in glioblastoma. | Malignant gliomas are the most common primary brain tumor in adults, but the prognosis for patients with these tumors remains poor despite advances in diagnosis and standard therapies such as surgery, radiation therapy, and chemotherapy. Progress in the treatment of gliomas now depends to a great extent on an increased... | 18,836,294 |
Immunotherapy of metastatic renal cell carcinoma. | In 1992, high-dose bolus interleukin (IL)-2 was granted Food and Drug Administration approval based on its ability to produce durable complete responses in a small number of patients with metastatic renal cell carcinoma (RCC). However, the substantial toxicity and limited efficacy that is associated with IL-2 has narro... | 18,836,337 |
Minocycline as adjunctive therapy for schizophrenia: an open-label study. | Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase, and has been shown to delay disease in a mouse model of neuropsychiatric disorders. Recently, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline (150 mg/... | 18,836,347 |
Minimally invasive multilevel percutaneous correction and fusion for adult lumbar degenerative scoliosis: a technique and feasibility study. | Prospective evaluation of 12 patients undergoing surgery for lumbar degenerative scoliosis. To assess the feasibility of minimally invasive spine surgery (MIS) techniques in the correction of lumbar degenerative deformity. Patient age, comorbidities, and blood loss may be limiting factors when considering surgical corr... | 18,836,355 |
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. | Mice carrying the recessive locus for peripheral T cell deficiency (Ptcd) have a block in thymic egress, but the mechanism responsible is undefined. Here we found that Ptcd T cells had an intrinsic migration defect, impaired lymphoid tissue trafficking and irregularly shaped protrusions. Characterization of the Ptcd lo... | 18,836,449 |
CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. | Dendritic cells (DCs) are 'professional' antigen-presenting cells that are key in the regulation of immune responses. Here we characterize a unique subset of tolerogenic DCs that expressed the chemokine receptor CCR9 and migrated to the CCR9 ligand CCL25, a chemokine linked to the homing of T cells and DCs to the gut. ... | 18,836,452 |
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). | The Ink4a-Arf-Ink4b locus has a crucial role in both cellular senescence and tumorigenesis. JmjC domain-containing histone demethylase 1b (Jhdm1b, also known as Kdm2b and Fbxl10), the mammalian paralog of the histone demethylase Jhdm1a (also known as Kdm2a and Fbxl11), has been implicated in cell-cycle regulation and t... | 18,836,456 |
Chemical control of protein stability and function in living mice. | Conditional control of protein function in vivo offers great potential for deconvoluting the roles of individual proteins in complicated systems. We recently developed a method in which a small protein domain, termed a destabilizing domain, confers instability to fusion protein partners in cultured cells. Instability i... | 18,836,461 |
Management of Wilms tumor: current standard of care. | Wilms tumor is the most common renal malignancy in children. In the 1930s, overall survival for children with Wilms tumor was approximately 30%. Use of multidisciplinary therapy, guided by results from multi-institutional, randomized trials, has substantially improved overall survival to about 90%. Management of Wilms ... | 18,836,464 |
The Janus face of dendritic cells in cancer. | On the basis of experimental models and some human data, we can assume that tumor outgrowth results from the balance between immunosurveillance (the extrinsic tumor suppressor mechanisms) and immunosubversion dictated by transformed cells and/or the corrupted surrounding microenvironment. Cancer immunosurveillance reli... | 18,836,473 |
NKG2D ligands in tumor immunity. | The activating receptor NKG2D (natural-killer group 2, member D) and its ligands play an important role in the NK, gammadelta(+) and CD8(+) T-cell-mediated immune response to tumors. Ligands for NKG2D are rarely detectable on the surface of healthy cells and tissues, but are frequently expressed by tumor cell lines and... | 18,836,475 |
Akt phosphorylation of La regulates specific mRNA translation in glial progenitors. | The Akt signaling pathway activity increases as normal tissue progresses to malignant transformation, and regulates the translation of specific messenger RNAs (mRNAs) through multiple mechanisms. We have identified one such mechanism of Akt-dependent translation control as involving the lupus autoantigen La. La is an R... | 18,836,485 |
Poor outcome in post transplant lymphoproliferative disorder with pulmonary involvement after allogeneic hematopoietic SCT: 13 years' experience in a single institute. | EBV-induced post transplant lymphoproliferative disorder (PTLD) continues to be a major complication after transplantation. Between January 1993 and April 2006, 12 cases of B-cell lymphoproliferative disorder were identified among 577 patients after allogeneic hematopoietic SCT (HSCT) with an overall incidence of 2.51%... | 18,836,488 |
Recent Advances and Future Advances in Time-of-Flight PET. | Simple theory predicts that the statistical noise variance in PET can be reduced by an order of magnitude by using time-of-flight (TOF) information. This reduction can be obtained by improving the coincidence timing resolution, and so would be achievable in clinical, whole body studies using with PET systems that diffe... | 18,836,513 |
Gender Differences in Patterns of Association Between Prosocial Behavior, Personality, and Externalizing Problems. | This study examines whether prosocial behavior and personality have independent or overlapping associations with adolescent externalizing problems. A total of 128 female and 103 male early adolescents (M = 13.6 years old) completed personality inventories. Prosocial behavior was assessed by peer nominations (N = 663). ... | 18,836,524 |
A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. | The PTEN tumour suppressor encodes a phosphatase, and its daf-18 orthologue in Caenorhabditis elegans negatively regulates the insulin/IGF-1 DAF-2 receptor pathway that influences lifespan in worms and other species. In order to identify new DAF-18 regulated pathways involved in aging, we initiated a candidate RNAi fee... | 18,836,529 |
The impact of work environment on mood disorders and suicide: Evidence and implications. | The purpose of this paper is to review the evidence estimating an impact of occupational factors on mood disorders and suicide, and the efficacy of interventions. This review is based on literature searches using Medline and Psych INFO from 1966 to 2007 (keywords: work stress, job insecurity, job strain, shift work, vi... | 18,836,547 |
The Relationship Between Gray Matter Morphometry and Neuropsychological Performance in a Large Sample of Cognitively Healthy Adults. | Voxel-based morphometry (VBM) was used to examine the relationship between gray matter (GM) volume and performance on two commonly used clinical neuropsychological measures of frontal lobe or executive function, the Trail Making Test part B (TrailsB) and the Controlled Oral Word Association Test (COWAT) in 221 cognitiv... | 18,836,573 |
Diagnosing and treating attention-deficit/hyperactivity disorder in adults. | Adult attention deficit/hyperactivity disorder (ADHD) is a valid and impairing psychiatric disorder. In this article, we review the diagnosis of ADHD in adults, focusing on symptom presentation differences between pediatric and adult ADHD as well as the importance of assessing functional impairments. Differentiating AD... | 18,836,579 |
Deficit schizophrenia: an update. | The criteria for deficit schizophrenia were designed to define a group of patients with enduring, primary (or idiopathic) negative symptoms. In 2001, a review of the literature suggested that deficit schizophrenia constitutes a disease separate from nondeficit forms of schizophrenia. Here we provide a review of new stu... | 18,836,581 |
Humeral shaft fractures and radial nerve palsy: to explore or not to explore...That is the question. | Humeral shaft fracture with radial nerve palsy has been a subject of debate since this entity was originally described by Holstein and Lewis in 1963. As the literature provides support for almost any approach in treating patients with this injury, surgeons have no definitive literary guidance. To clarify how physicians... | 18,836,600 |
Total wrist arthroplasty. | In the article, I review the history of total wrist arthroplasty designs; give an overview of and design rationale for the ReMotion (Small Bone Innovations, Morrisville, PA) total wrist arthroplasty; describe the indications, technique, and postoperative care for this implant; and present some early, very encouraging r... | 18,836,607 |
Radial endoscopic ultrasonography in the preoperative staging of pancreatic cancer. | Endoscopic ultrasonography (EUS) is a diagnostic method that aims to detect and stage tumors of the pancreas more accurately. It has a high predictive role regarding tumor resectability. The present paper aims to assess the diagnostic accuracy of radial EUS in the staging of pancreatic cancer as well as the role of EUS... | 18,836,619 |
Prospective study on warfarin and regional chemotherapy in patients with pancreatic carcinoma. | The aim is to prospectively examine the effect of regional gemcitabine and mitomycin-C with systemic gemcitabine together with warfarin in patients with inoperable pancreatic carcinoma, and compare the effect to systemic gemcitabine alone. Seventeen patients received 1.25 mg of warfarin daily, gemcitabine 800 mg/m2 on ... | 18,836,621 |
[Cytokine-eluting stents as new drug-delivery devices for angiogenic therapy]. | The stimulation of the endogenous adaptive vessel growth (angiogenesis, arteriogenesis) provides a promising therapeutic approach for the large number of patients with vascular occlusive disease that is not eligible for current interventional treatments. Despite the proven efficacy of various factors in pre-clinical ex... | 18,836,644 |
Understanding fetal alcohol spectrum disorders (FASDs): toward identification of a behavioral phenotype. | Fetal alcohol spectrum disorders (FASDs) currently represent the leading cause of mental retardation in North America, ahead of Down syndrome and cerebral palsy. The damaging effects of alcohol on the developing brain have a cascading impact on the social and neurocognitive profiles of affected individuals. Researchers... | 18,836,653 |
Ruptured jejunal diverticulum due to a single-band small bowel obstruction. | Jejunal diverticulosis is rare and often goes unnoticed until complications occur. The diverticula are true, acquired diverticula and often asymptomatic. Jejunal diverticulosis can be associated with diverticulosis of the duodenum, ileum, and colon. Here we describe a patient with known severe diverticular disease of t... | 18,836,661 |
Benign hepatic portal venous gas in a critically ill patient. | Hepatic portal venous gas (HPVG) formation is regarded as a sign of serious intra-abdominal process. This report presents an abdominal CT scan of a patient with incidental but rare finding of HPVG after nasogastric intubation. The presence of HPVG should prompt a thorough diagnostic evaluation to immediately rule out a... | 18,836,664 |
[Steady-state responses of the auditory system: a comparison of different methods]. | Determining the hearing threshold in children is one of the most important topics in audiology. Because the existing methods-brainstem evoked response audiometry (BERA) and cortical evoked response audiometry (CERA)-show some severe insufficiencies, it is necessary to look for improved methods. A promising approach may... | 18,836,669 |
Effects of atorvastatin on calcium-regulating proteins: a possible mechanism to repair cardiac dysfunction in spontaneously hypertensive rats. | Previous clinical and experimental studies have demonstrated that statins, the inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, can improve left ventricular function in damaged hearts. Also, the normal expression of Ca(2+) regulatory proteins is critical for efficient myocardial function. However, it is s... | 18,836,677 |
Modeling the effects of resection, radiation and chemotherapy in glioblastoma. | The standard treatment for newly diagnosed glioblastoma multiforme is surgical resection followed by radiotherapy and chemotherapy. Most studies on these treatments are retrospective clinical data analysis. To integrate these studies, a mathematical model is developed. The model predicts the survival time of patients w... | 18,836,688 |
Hesitation behaviour of hoverflies Sphaerophoria spp. to avoid ambush by crab spiders. | Pollinators possess several antipredator adaptations that minimise predation risk during foraging. In addition to morphological adaptations, hoverflies might have behavioural antipredator adaptations. We conducted three field experiments to investigate whether the "hesitation behaviour" of hoverflies Sphaerophoria spp.... | 18,836,694 |
Characterization of new oxidation products of 9H-carbazole and structure related compounds by biphenyl-utilizing bacteria. | 9H-Carbazole and its derivatives are useful for versatile pharmacological applications. To obtain different derivatives of 9H-carbazole, 24 isolates of biphenyl-utilizing bacteria have been investigated regarding their ability to produce hydroxylated 9H-carbazole metabolites. Our analyses showed that 9H-carbazole was p... | 18,836,714 |
Her-2 DNA versus cell vaccine: immunogenicity and anti-tumor activity. | Direct comparison and ranking of vaccine formulations in pre-clinical studies will expedite the identification of cancer vaccines for clinical trials. Two human ErbB-2 (Her-2) vaccines, naked DNA and whole cell vaccine, were tested side-by-side in wild type and Her-2 transgenic mice. Both vaccines can induce humoral an... | 18,836,716 |
Apical hypertrophic cardiomyopathy in childhood: a long-term follow-up report of two cases. | We present two children with apical hypertrophic cardiomyopathy (APH), both of whom remained asymptomatic for more than 15 years. The inverted T-wave on electrocardiograms and myocardial hypertrophy mostly confined to the apical region on echocardiograms showed no significant changes during follow-up. Magnetic resonanc... | 18,836,757 |
An auxiliary method to reduce potential adverse impacts of projected land developments: subwatershed prioritization. | An index based method is developed that ranks the subwatersheds of a watershed based on their relative impacts on watershed response to anticipated land developments, and then applied to an urbanizing watershed in Eastern Pennsylvania. Simulations with a semi-distributed hydrologic model show that computed low- and hig... | 18,836,760 |
Transcatheter closure of a chronic iatrogenic arteriovenous fistula between the carotid artery and the brachiocephalic vein with an Amplatzer duct occluder in combination with a carotid stent. | We report an original method of transcatheter closure of an arteriovenous fistula using the combination of an Amplatzer PDA occluder and a carotid stent. The fistula was between the left carotid artery and the brachiocephalic vein. The patient had significant left-to-right shunt and was highly symptomatic. Due to the l... | 18,836,769 |
Methods for assessing leg length discrepancy. | The use of accurate and reliable clinical and imaging modalities for quantifying leg-length discrepancy (LLD) is vital for planning appropriate treatment. While there are several methods for assessing LLD, we questioned how these compared. We therefore evaluated the reliability and accuracy of the different methods and... | 18,836,788 |
Adjuvant treatments for resectable pancreatic cancer. | Pancreatic cancer remains one of the most challenging malignancies to treat successfully. The majority of patients present with unresectable advanced-stage cancer, and only 20% of patients can undergo resection. Even if surgical resection is performed, the recurrence rate is high and the survival rate after surgery is ... | 18,836,798 |
Efficacy of vessel sealing system for major Glisson bundles and major bile ducts. | The efficacies of vessel sealing system (VSS) devices for major Glisson bundles and major bile ducts have not yet been determined. Male pigs (n = 6) and a LigaSure V device and an Atlas 20 (Valleylab, Boulder, CO, USA) device were used in this study. After laparotomy, the common bile duct and the right and left first-d... | 18,836,807 |
Alterations in Event Related Potentials (ERP) associated with tinnitus distress and attention. | Tinnitus related distress corresponds to different degrees of attention paid to the tinnitus. Shifting attention to a signal other than the tinnitus is therefore particularly difficult for patients with high tinnitus related distress. As attention effects on Event Related Potentials (ERP) have been shown this should be... | 18,836,827 |
Bayesian variable selection for the Cox regression model with missing covariates. | In this paper, we develop Bayesian methodology and computational algorithms for variable subset selection in Cox proportional hazards models with missing covariate data. A new joint semi-conjugate prior for the piecewise exponential model is proposed in the presence of missing covariates and its properties are examined... | 18,836,829 |
The targeting of endothelial progenitor cells to a specific location within a microfluidic channel using magnetic nanoparticles. | A common problem with the in vivo therapeutic applications of cells is that cells can rapidly disappear into the circulatory system after an injection. Magnetic nanoparticles can be used to solve this problem. Bacterial magnetic nanoparticles were used in this study for targeting stem cells at a specific location withi... | 18,836,835 |
Development of a fully implantable wireless pressure monitoring system. | A fully implantable wireless pressure sensor system was developed to monitor bladder pressures in vivo. The system comprises a small commercial pressure die connected via catheter to amplifying electronics, a microcontroller, wireless transmitter, battery, and a personal digital assistant (PDA) or computer to receive t... | 18,836,836 |
Patient reported outcome measures: a model-based classification system for research and clinical practice. | The umbrella term Patient Reported Outcomes (PRO) has been successfully proposed for instruments measuring perceived health outcomes, but its relationship to current conceptual models remains to be established. Our aim was to develop a classification system for PRO measures based on a valid conceptual model. We reviewe... | 18,836,850 |
Discoidin domain receptor 1, a tyrosine kinase receptor, is upregulated in an experimental model of remyelination and during oligodendrocyte differentiation in vitro. | The discoidin domain receptor (DDR1) is highly expressed in oligodendrocytes during the neurodevelopmental myelination process and is genetically associated to schizophrenia. In this study, we aimed to further assess the involvement of DDR1 in both remyelination and oligodendrocyte differentiation. In the mouse model o... | 18,836,851 |
Metallic biomaterials. | Ti alloys composed of nontoxic and allergy-free elements and Ni-free stainless steels and Co-Cr alloys are currently being developed. Ni-free Ti alloys exhibiting superelastic behavior, or the shape memory effect, are also being developed. beta-type Ti alloy with a low elastic modulus has proved to be effective for inh... | 18,836,869 |
Simulation of the fluid dynamics in artificial aortic roots: comparison of two different types of prostheses. | As a consequence of the growing number of elderly people, the incidence of degenerative aortic diseases continues to increase. Often, artificial aortic roots are needed to replace the native tissue. Some physical characteristics of the artificial aortic root, however, are quite different from native aorta and need to b... | 18,836,872 |
Suicidality in Chinese adolescents in Hong Kong: the role of family and cultural influences. | Adolescent suicidal ideation has found to predict suicidal behaviors and psychopathology in adulthood. Previous studies focused solely on the medical and environmental risk factors, which were insufficient to give a holistic picture of adolescent suicidality. To assess the role of affective and cognitive attributes in ... | 18,836,885 |
Electromagnetic navigation bronchoscopy in combination with PET-CT and rapid on-site cytopathologic examination for diagnosis of peripheral lung lesions. | The combination of electromagnetic navigation bronchoscopy (ENB), PET-CT, and rapid on-site cytopathologic examination (ROSE) for the routine diagnostic work-up of peripheral lung lesions has not been evaluated previously. The aim of this study was to determine the accuracy and safety of ENB in combination with PET-CT ... | 18,836,886 |
Mitochondrial fatty acid oxidation defects--remaining challenges. | Mitochondrial fatty acid oxidation defects have been recognized since the early 1970s. The discovery rate has been rather constant, with 3-4 'new' disorders identified every decade and with the most recent example, ACAD9 deficiency, reported in 2007. In this presentation we will focus on three of the 'old' defects: med... | 18,836,889 |
Analysis of the free range behaviour of laying hens and the genetic and phenotypic relationships with laying performance. | 1. Over twelve 28-d laying periods (almost one year), 272 laying hens of the Lohmann Silver strain, individually tagged with transponders, were monitored on their ranging behaviour and laying performance in an aviary system with an adjacent winter garden. 2. From laying periods 1 to 12, the daily frequency of passages ... | 18,836,899 |
Effect of egg turning and incubation time on carbonic anhydrase gene expression in the blastoderm of the Japanese quail (Coturnix c. japonica). | 1. The gene expression of carbonic anhydrase, a key enzyme for the production of sub-embryonic fluid (SEF), was assessed in turned and unturned eggs of the Japanese quail. The plasma membrane-associated isoforms CA IV, CA IX, CA XII, CA XIV, and the cytoplasmic isoform CA II, were investigated in the extra-embryonic ti... | 18,836,903 |
Selenium requirement of growing male turkeys. | 1. The aim of the experiment was to estimate the selenium requirement of growing male turkeys using the selenium concentrations in different organs and blood plasma and by fitting a continuous broken line to the activity of glutathione peroxidase in liver and plasma. 2. Newly hatched male BUT BIG 6 turkeys were fed eit... | 18,836,905 |
Circadian serum concentrations of tylosin in broilers after feed or water medication. | 1. Because tylosin is a time-dependent antibacterial agent, and because feeding and drinking of broilers decreases in late afternoon and ceases in the dark, it was hypothesised that serum concentrations of this drug are greatly reduced during the dark period. 2. The trial was carried out in a commercial poultry house, ... | 18,836,909 |
Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix Plus). | 1. Toxic effects of two concentrations (0.5 and 1 mg/kg) of ochratoxin A (OTA) and attenuating effects of a toxin deactivator (Mycofix Plus(MTV INSIDE)) containing the yeast Trichosporon mycotoxinivorans on the performance (feed conversion ratio; body weight gain), serum enzymes (lactate dehydrogenase, gamma-glutamyltr... | 18,836,911 |
Functional and ultrastructural analysis of endothelial-like cells derived from bone marrow stromal cells. | Recent studies have suggested that bone marrow stromal cells (BMSC) have the potential to differentiate into endothelial cells. However, the physiologic functions of the endothelial-like cells derived from BMSC have not been well studied. Human BMSC were induced to differentiate into endothelial-like cells with a combi... | 18,836,916 |
Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways. | Paraquat (PQ) (1,1-dimethyl-4,4'-bipyridinium dichloride), a widely used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). In this sense, understanding of the molecular mechanism underlying PQ-induced toxicity to neural cells is important for optimal use as w... | 18,836,921 |
Physicochemical characteristics of aerosol particles generated during the milling of beryllium silicate ores: implications for risk assessment. | Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD). Inhalation of beryllium aerosols generated during primary beryllium production and machining of the me... | 18,836,922 |
Partial remission indicates poor functioning and a high level of psychiatric symptoms: a 3-phase 6-year follow-up study on major depression. | Patients with depression in partial remission are at high risk of relapse, but factors associated with being in this outcome group are not well known. We conducted a clinical survey to examine the course of major depression in 87 patients during a follow-up period of 6 years. Beck Depression Inventory (BDI) scores indi... | 18,836,926 |
Recognizing the protruding eye. | It is currently unknown how much exophthalmos may be noticeable to an observer. The authors determined the threshold for detection of exophthalmos may be 4 millimeters. To determine the threshold for detection of exophthalmos by an observer. The Massachusetts Eye and Ear Infirmary Ophthalmic Plastics imaging database w... | 18,836,932 |
[Providing grief counseling to a major depressive elderly widower: a nurse's experience]. | The death of a spouse is both a major loss and a tremendous life stressor for the partner left behind. Such has been shown to be particularly hard on the elderly. This article describes a nurse's experience caring for an elderly patient suffering from major depression resulting from the death of his wife. While providi... | 18,836,981 |
Breast radiation therapy guideline implementation in low- and middle-income countries. | Radiation therapy plays a critical role in the management of breast cancer and often is unavailable to patients in low- and middle-income countries (LMCs). There is a need to provide appropriate equipment and to improve the techniques of administration, quality assurance, and use of resources for radiation therapy in L... | 18,837,022 |
Locally advanced breast cancer: treatment guideline implementation with particular attention to low- and middle-income countries. | The management of locally advanced breast cancer (LABC) is guided by scientific advances but is limited by local resources and expertise. LABC remains very common in low-resource countries. The Systemic Therapy Focus Group met as part of the Breast Health Global Initiative (BHGI) Summit in Budapest, Hungary, in October... | 18,837,023 |
Effective but cost-prohibitive drugs in breast cancer treatment: a clinician's perspective. | New pharmacologic treatments for early-stage breast cancer have been proven effective, but many of them are cost prohibitive in low economic settings. Differences in breast cancer mortality rates between developed and developing countries may be because of differences in screening and treatment options, some of which m... | 18,837,028 |
ATP induces long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn: the roles of P2X4 receptors and p38 MAPK in microglia. | Many studies have shown that adenosine triphosphate (ATP), as a neurotransmitter, is involved in plastic changes of synaptic transmission in central nervous system. In the present study, we tested whether extracellular ATP can induce long-term potentiation (LTP) of C-fiber-evoked field potentials in spinal dorsal horn.... | 18,837,052 |
How we have learned about the complexity of physiology, pathobiology and pharmacology of bile acids and biliary secretion. | During the last decades the concept of bile secretion as merely a way to add detergent components to the intestinal mixture to facilitate fat digestion/absorption and to eliminate side products of heme metabolism has evolved considerably. In the series of mini-reviews that the World Journal of Gastroenterology is to pu... | 18,837,076 |
Intestinal bile acid physiology and pathophysiology. | Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport a... | 18,837,078 |
Physiology of bile secretion. | The formation of bile depends on the structural and functional integrity of the bile-secretory apparatus and its impairment, in different situations, results in the syndrome of cholestasis. The structural bases that permit bile secretion as well as various aspects related with its composition and flow rate in physiolog... | 18,837,079 |
Chilli anthracnose disease caused by Colletotrichum species. | Anthracnose disease is one of the major economic constraints to chilli production worldwide, especially in tropical and subtropical regions. Accurate taxonomic information is necessary for effective disease control management. In the Colletotrichum patho-system, different Colletotrichum species can be associated with a... | 18,837,103 |
Advances in the phylogenesis of Agaricales and its higher ranks and strategies for establishing phylogenetic hypotheses. | We present an overview of previous research results on the molecular phylogenetic analyses in Agaricales and its higher ranks (Agaricomycetes/Agaricomycotina/Basidiomycota) along with the most recent treatments of taxonomic systems in these taxa. Establishing phylogenetic hypotheses using DNA sequences, from which an u... | 18,837,104 |
[Medicinal management of pain and symptoms following the withdrawal of treatment in babies and children]. | We present three cases to illustrate the end-of-life care after withdrawal of mechanical ventilation. In a one-year-old girl with meningococcal septic shock, muscle relaxants were continued when mechanical ventilation was withdrawn. In a 10-day-old girl with perinatal asphyxia a high dose of fentanyl was given before m... | 18,837,178 |
[Ventricular assist device implantation as a bridge to cardiac transplantation in two adolescents with end-stage cardiomyopathy and heart failure as a result of anthracycline use]. | In a adolescent women aged 15 and 17 years respectively, severe heart failure developed within a few months of anthracycline chemotherapy given for osteosarcoma. In the guidelines of the European Society of Cardiology, malignancy with a remission duration of less than 5 years is an absolute contraindication to cardiac ... | 18,837,186 |
Motor threshold as indicator of premotor and motor cortex excitability. | The premotor cortex is a second generator of motorics, involved in mass inborn movements performance, and in pathology--in genesis of spasticity and other motor disorders. As far as the repetitive transcranial magnetic stimulation (TMS) is expected to be a therapeutic tool in some movement disorders, the investigation ... | 18,837,191 |
eToims twitch relief method in chronic refractory myofascial pain (CRMP). | CRMP management involves electrical stimulation of motor points. To demonstrate that Electrical Twitch-Obtaining Intramuscular Stimulation (eToims) using ET127 system for noninvasive motor point stimulation is safe and efficacious in CRMP management. Longitudinal observation of consecutive self-pay outpatients treated ... | 18,837,197 |
Prevalence of opioid dispensings and concurrent gastrointestinal medications in an elderly population from Ontario, Canada. | Although opioid analgesics are effective therapeutic agents, gastrointestinal (GI) side effects represent a challenging consequence of treatment. In an elderly population, age-related physiological changes, such as decreased GI functioning and dehydration, may compound the adverse effects of opioids; therefore, appropr... | 18,837,202 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.