title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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[Systemic lupus erythematosus and pregnancy]. | Systemic lupus erythematosus (SLE) is a complex autoimmune disease that predominantly affects women of childbearing age. Prognosis of SLE pregnancy has dramatically improved with the advent in therapeutic management of SLE and in the obstetric care. Consequently, pregnancy is possible in SLE patients when the disease i... | 18,848,416 |
Oversized acetabular socket causing groin pain after total hip arthroplasty. | The causes of groin pain after total hip arthroplasty are numerous, and the condition itself is disabling. Therefore, it is imperative that the cause of the pain is identified and managed appropriately. We report a case where the patient had groin pain after total hip arthroplasty as a result of an oversized cementless... | 18,848,418 |
Undernutrition in geriatric institutions in South-West France: policies and risk factors. | This study aimed to describe the nutritional status of geriatric home residents according to their place of dwelling and to identify institutional factors associated with higher rates of undernutrition. All institutions (514) in the Aquitaine region were interviewed for staff ratio, nutritional procedures, staff traini... | 18,848,433 |
[Adenocarcinoma of the rectum in a 14-year-old]. | Colorectal cancer is rare in children and adolescents. It is usually associated with predisposing genetic factors, aggressive histology, and poor prognosis. Two familial syndromes are best characterized, hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis. They are autosomal dominant inherited ... | 18,848,439 |
The TSC-mTOR signaling pathway regulates the innate inflammatory response. | The innate inflammatory immune response must be tightly controlled to avoid damage to the host. Here, we showed that the tuberous sclerosis complex-mammalian target of rapamycin (TSC-mTOR) pathway regulated inflammatory responses after bacterial stimulation in monocytes, macrophages, and primary dendritic cells. Inhibi... | 18,848,473 |
Pediatric eye injuries related to consumer products in the United States, 1997-2006. | This study examines which consumer products are most commonly associated with pediatric eye injuries that are treated in emergency departments in the United States. The results demonstrate that, overall, boys experienced proportionally more consumer product-related eye injuries than girls, but eye injuries from specifi... | 18,848,479 |
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. | Genomic imprinting regulates parental-specific expression of particular genes and is required for normal mammalian development. How imprinting is established during development is, however, largely unknown. To address this question, we studied the mouse Kcnq1 imprinted cluster at which paternal-specific silencing depen... | 18,848,501 |
The interaction of biological and noxious transition metals with the zinc probes FluoZin-3 and Newport Green. | Zinc-sensitive fluorescent probes have become increasingly important in the investigation of the cellular roles of zinc. There is, however, little information on how the other transition metals in cells may influence the measurement of zinc. We have characterized in vitro the interaction of the nominal zinc indicators ... | 18,848,515 |
Effects of ceramide and other simple sphingolipids on membrane lateral structure. | The available data concerning the ability of ceramide and other simple sphingolipids to segregate laterally into rigid, gel-like domains in a fluid bilayer has been reviewed. Ceramides give rise to rigid ceramide-enriched domains when their N-acyl chain is longer than C12. The high melting temperature of hydrated ceram... | 18,848,519 |
The extracellular domain of luteinizing hormone receptor dictates its efficiency of maturation. | The processing of luteinizing hormone receptor (LHR) shows marked differences in different species. While the human LHR is predominantly expressed as the mature, 90kDa species, rat LHR exists mostly in the 70kDa precursor form. Since the extracellular domain of the LHR is unusually large in comparison with other G prot... | 18,848,524 |
Species and agonist dependent zinc modulation of endogenous and recombinant ATP-gated P2X7 receptors. | Zinc (Zn2+) and copper (Cu2+) are key signalling molecules in the immune system and regulate the activity of many ion channels. Both Zn2+ and Cu2+ potently inhibit rat P2X7 receptors via a binding site identified by mutagenesis. Here we show that extracellular Cu2+ also potently inhibits mouse P2X7 receptors. By contra... | 18,848,528 |
Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats. | It has been investigated, based on a rat model of human exposure to cadmium (Cd), whether zinc (Zn) supplementation may prevent Cd-induced alterations in lipid metabolism. For this purpose, the concentrations of free fatty acids (FFA), phospholipids (PL), triglycerides (TG), total cholesterol (TCh), and high and low de... | 18,848,534 |
Effects of alpha-tocopherol (vitamin E) on the stability and lipid dynamics of model membranes mimicking the lipid composition of plant chloroplast membranes. | Tocopherol (vitamin E) is widely recognized as a cellular antioxidant. It is essential for human and animal health, but only synthesized in photosynthetic organisms, where it is localized in chloroplast membranes. While many studies have investigated non-antioxidative effects of tocopherol on phospholipid membranes, no... | 18,848,546 |
Behavioral phenotypes persist after gonadal steroid manipulation in white-throated sparrows. | White-throated sparrows (Zonotrichia albicollis) exhibit a behavioral polymorphism that segregates with a plumage marker. Individuals with a white stripe (WS) on the crown engage in an aggressive strategy that involves more singing, whereas individuals with a tan stripe (TS) sing less and engage in more parental care. ... | 18,848,562 |
Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and peptide mass fingerprinting. | Intrafamily gene diversification has led to three prototype galectins in chicken [i.e., chicken galectin (CG)-1A, CG-1B, and CG-2] that show distinct expression profiles and developmental regulation. In order to pinpoint structural disparities among them, we determined the crystal structure of CG-1B. Alteration of the ... | 18,848,566 |
The high-resolution NMR structure of the early folding intermediate of the Thermus thermophilus ribonuclease H. | Elucidation of the high-resolution structures of folding intermediates is a necessary but difficult step toward the ultimate understanding of the mechanism of protein folding. Here, using hydrogen-exchange-directed protein engineering, we populated the folding intermediate of the Thermus thermophilus ribonuclease H, wh... | 18,848,567 |
Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner. | It has been recently proposed that pro-inflammatory genes such as cyclooxygenase-2 (COX-2) play a key role in the aging process. However, it remains unclear whether the pro-inflammatory activity of COX-2 is involved in the aging process and whether COX-2 inhibitors prevent aging. We therefore examined the effect of COX... | 18,848,576 |
Real-time RT-PCR (TaqMan) assays for the detection of viruses associated with Rugose wood complex of grapevine. | Real-time TaqMan RT-PCR (TaqMan RT-PCR) assays were developed to detect the viruses associated with Rugose wood complex of grapevines. The viruses detected were Rupestris stem pitting-associated virus in the genus Foveavirus, Grapevine virus A, Grapevine virus B and Grapevine virus D in the genus Vitivirus. The coat pr... | 18,848,580 |
Identification of outer membrane proteins with emulsifying activity by prediction of beta-barrel regions. | Microbial bioemulsifiers are secreted by many bacteria and are important for bacterial interactions with hydrophobic substrates or nutrients and for a variety of biotechnological applications. We have recently shown that the OmpA protein in several members of the Acinetobacter family has emulsifying properties. These p... | 18,848,588 |
Vaccination coverage and awareness of infectious risks in patients with an absent or dysfunctional spleen in the Netherlands. | To evaluate the current practice to prevent infections in patients with an absent or dysfunctional spleen in a part of the Netherlands. To measure serum antibody levels against Streptococcus pneumoniae and Haemophilus influenzae type b. Observational study of vaccination coverage by analysis of questionnaires and serum... | 18,848,594 |
Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of rats. | The arsenic accumulation, distribution and influences on metallothionein-1 (MT-1) expression and other trace elements in various organs were examined in rats orally exposed to sodium arsenate (iAs(V)). Rats received a dose of 0, 1, 10 and 100ppm of iAs(V) in drinking water daily for 4- and 16-weeks. Arsenic seems to be... | 18,848,598 |
Effects of velocity and motion-onset delay on detection and discrimination of sound motion. | The effect of velocity on auditory motion processing in combination with a motion-onset delay was investigated in two experiments. The detection of motion onset and discrimination of motion direction were studied, employing a psychophysical reaction time task. Listeners were presented with sounds moving along the front... | 18,848,613 |
Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct. | The toxicity of platinum(II) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin, cis-[PtCl(2)(NH(3))(2)], [PtCl(2)(SMC)] and [PtCl(2)(DMSO)(2)] (where SMC is S-methyl-l-cysteine and DMSO is dimeth... | 18,848,615 |
Quality of regulatory elements in Drosophila retrogenes. | Retrogenes are processed copies of genes that are inserted into new genomic regions and that acquire new regulatory elements from the sequences in their surroundings. Here we use a comparative approach of phylogenetic footprinting and a non-comparative approach of measuring motif over-representation in retrogenes in or... | 18,848,618 |
Determinants of the NF-kappaB response to acute psychosocial stress in humans. | Previous research has shown that psychosocial stress is associated with an increased activity of the transcription factor nuclear factor-kappaB (NF-kappaB), a major inducer of inflammatory genes. While considerable individual variation has been noted, factors contributing to this variation have not been described so fa... | 18,848,620 |
Issues with threshold masking in voxel-based morphometry of atrophied brains. | There is great interest in using automatic computational neuroanatomy tools to study ageing and neurodegenerative disease. Voxel-based morphometry (VBM) is one of the most widely used of such techniques. VBM performs voxel-wise statistical analysis of smoothed spatially normalised segmented Magnetic Resonance Images. T... | 18,848,632 |
Mitochondrial DNA damage and its potential role in retinal degeneration. | Mitochondria are central to retinal cell function and survival. There is increasing evidence to support an association between mitochondrial dysfunction and a number of retinal pathologies including age-related macular degeneration (AMD), diabetic retinopathy and glaucoma. The past decade has highlighted mitochondrial ... | 18,848,639 |
The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles? | One of the most challenging problems, if not the most challenging, in drug development is not to develop drugs to treat diseases of the central nervous system (CNS), but to manage to distribute them to the CNS across the blood-brain barrier (BBB) using transvascular routes following intravenous administration. The deve... | 18,848,640 |
Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics. | Type A (I) lantibiotics are cationic antimicrobial peptides that have a potential usefulness in treating infectious diseases. They are known to have a potent and broad spectrum of activity, an insignificant cytotoxicity, and demonstrated efficacy in animal infection models, suggesting therapeutic potential. In this rev... | 18,848,642 |
Variations in admission practices for adolescents with anorexia nervosa: a North American sample. | The purpose of this study was to assess the variability in admission practices and medical inpatient care for adolescent patients with anorexia nervosa (AN). Participants consisted of members of the 2001-2003 Eating Disorder Special Interest Group from the Society for Adolescent Medicine who completed a structured tele... | 18,848,669 |
Cardiovascular abnormalities in Turner's syndrome: what prevention? | Cardiovascular complications in Turner's syndrome are the most common cause of excess early mortality, with a life expectancy that may be reduced by more than 10 years. Congenital cardiac abnormalities are described in approximately one third of patients. These abnormalities are mostly left heart obstructions, the most... | 18,848,691 |
Fluorescent isotope-coded affinity tag (FCAT). I: Design and synthesis. | A novel class of isotope-coded affinity tag is proposed possessing a fluorescent feature, referred to as fluorescent isotope-coded affinity tag (FCAT), to provide a new tool for quantitative proteomics. The label is designed to bind cysteine containing proteins or peptides. The FCAT reagent comprises four functional el... | 18,848,712 |
The Asthma Control and Communication Instrument: a clinical tool developed for ethnically diverse populations. | Lower levels of quality asthma care among racially diverse populations might be due to inaccurate disease status assessments. The Asthma Control and Communication Instrument (ACCI) is a new tool that captures patient report of disease status during routine care. We sought to test the ACCI's psychometric properties in a... | 18,848,721 |
Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior. | A series of amphiphilic tri-block copolymers based on poly(lactide-co-glycolide)-b-poly(ethylene oxide)-b-poly(lactide-co-glycolide) (PLGE) with various segment ratios of PEO/PLGA and segment lengths of PEO were synthesized. Multi-morphological biodegradable nanoparticles - PLGE-NPs were fabricated by an improved emuls... | 18,848,724 |
The interaction of native calf thymus DNA with Fe(III)-dipyrido[3,2-a:2',3'-c]phenazine. | The mono and bis dipyrido[3,2-a:2',3'-c]phenazine (dppz) adducts of iron(III) chloride, i.e. [Fe(dppz)]Cl(3) and [Fe(dppz)(2)]Cl(3), have been synthesized and characterized. The interaction of the Fe(III)dppz hydrolyzed aquo complex with native calf thymus DNA has been monitored as a function of the metal complex-DNA m... | 18,848,728 |
Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region. | Between January 2005 and December 2005, 199 meticillin-resistant Staphylococcus aureus (MRSA) isolates were obtained from non-hospitalised patients presenting skin and soft tissue infections to local general practitioners. The study area incorporated 57 surgeries from three Primary Care Trusts in the Lichfield, Tamwort... | 18,848,735 |
Integrating co-morbid depression and chronic physical disease management: identifying and resolving failures in self-regulation. | Research suggests that treatments for depression among individuals with chronic physical disease do not improve disease outcomes significantly, and chronic disease management programs do not necessarily improve mood. For individuals experiencing co-morbid depression and chronic physical disease, demands on the self-reg... | 18,848,740 |
Cortical gray matter lesions in acute encephalopathy with febrile convulsive status epilepticus. | In acute encephalopathy with febrile convulsive status epilepticus (AEFCSE), subcortical white matter lesions on diffusion-weighted images are sometimes encountered on magnetic resonance imaging (MRI), such as in acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). We report here a severe case... | 18,848,752 |
Selective medical treatment of infected aneurysms of the aorta in high risk patients. | Infected aneurysm of the aorta is almost always fatal without undergoing aortic resection. Medical treatment was attempted selectively in patients who were considered too high risk for surgery. We review our experience with 22 patients treated without undergoing aortic resection over 12 years. Retrospective chart revie... | 18,848,757 |
Characterising vancomycin's immunotoxic profile using Swiss and CFW mice as an experimental model. | Immunotoxicology can lead to determining the adverse effects of different compounds on the immune system. Sometimes, many drugs (especially antibiotics) induce immune alterations, mainly auto-immunity. This study was aimed at determining vancomycin's immunotoxic effect by comparing the original molecule to two of the m... | 18,848,766 |
Soluble TNFR II/IgG1 Fc fusion protein treatment in the LPS-mediated septic shock of rats. | Tumor necrosis factor-alpha (TNF-alpha) is thought to play a major role in systemic inflammation associated with sepsis. A potent TNF antagonist, a recombinant fusion protein that consists of the soluble TNF receptor (p75) linked to the Fc portion of human IgG1 (sTNFR II/IgG1 Fc fusion protein, sTNFR:Fc), has been show... | 18,848,768 |
Composition and production rate of solid waste from dental laboratories in Xanthi, Greece. | The composition and production rate of solid waste produced by four dental laboratories were measured in the Prefecture of Xanthi (Greece) during 2002. The selected dental labs in Xanthi were expected to produce approximately 75% of the waste produced from of all seven dental laboratories in the Xanthi Prefecture. Samp... | 18,848,772 |
Recycling of waste glass as a partial replacement for fine aggregate in concrete. | Waste glass creates serious environmental problems, mainly due to the inconsistency of waste glass streams. With increasing environmental pressure to reduce solid waste and to recycle as much as possible, the concrete industry has adopted a number of methods to achieve this goal. The properties of concretes containing ... | 18,848,773 |
Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors. | Based on our recent findings that piperine is a potent Staphylococcus aureus NorA efflux pump inhibitor (EPI), 38 piperine analogs were synthesized and bioevaluated for their EPI activity. Twenty-five of them were found active with potentiating activity equivalent or more than known EPIs like reserpine, carsonic acid a... | 18,848,780 |
A genetic contribution to circulating cytokines and obesity in children. | Cytokines are considered to be involved in obesity-related metabolic diseases. Study objectives are to determine the heritability of circulating cytokine levels, to investigate pleiotropy between cytokines and obesity traits, and to present genome scan results for cytokines in 1030 Hispanic children enrolled in VIVA LA... | 18,848,781 |
Management of Stage II testicular seminoma over a period of 40 years. | To review the treatment, toxicity, and outcomes in patients with Stage II seminoma after orchidectomy. A retrospective chart review of all patients with Stage II seminoma referred for initial treatment, from 1965 to 2005, was performed. Treatment approaches, toxicity, and outcomes were analyzed. A total of 106 patients... | 18,848,787 |
Ultrasound-promoted synthesis of novel dispirocyclic frameworks from aza-Claisen rearrangements of Baylis-Hillman amines. | A novel tetracyclic frameworks of dispiropyrrolizidines can be obtained in moderate to good yields via the 1,3-dipolar cycloaddition of azomethine ylides with dipolarophiles derived from aza-Claisen rearrangement of Baylis-Hillman amines. The transformations are highly regioselective and stereoselective, affording the ... | 18,848,799 |
Management of post-partum hemorrhage in low-income countries. | The provision of safe and effective delivery care for all women in poor countries remains elusive, resulting in a continuing burden of mortality in general and mortality from post-partum haemorrhage in particular. Deployment of a functional health system and effective linkage of the health system to communities are the... | 18,848,808 |
Digital image referral for suspected skin malignancy--a pilot study of 300 patients. | Referral of suspect skin cancers as well as non malignant symptomatic skin lesions using high quality digital images transferred via a secure electronic referral system (ERS) potentially offers significant advantages regarding speed of referral, diagnosis and subsequent treatment over conventional pathways. However con... | 18,848,815 |
Bovine serum amine oxidase and spm potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress. | It was previously demonstrated that bovine serum amine-oxidase (BSAO) and SPM (SPM) addition to cancer cells induces cell growth inhibition and over-run the multi-drug resistance (MDR) phenotype through the oxidative stress caused by polyamine metabolites. In this study, it is reported that BSAO/SPM enzymatic system an... | 18,848,847 |
Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity. | Critical issues for cytotoxic lymphocyte (CTL) cross-priming are (a) the maturation state of dendritic cells (DC), (b) the source of the tumor-associated antigens (TAA) and (c) the context in which they are delivered to DCs. Drug-induced apoptosis has recently been implicated in CTL cross-priming. However, since drug-t... | 18,848,858 |
Fin-mutant female zebrafish (Danio rerio) exhibit differences in association preferences for male fin length. | Females often choose to associate with males that have exaggerated traits. In fishes, this may reflect an overall preference for larger size in a potential mate. Female zebrafish (Danio rerio) prefer males with larger bodies but not longer fins. The availability of mutant and transgenic strains of zebrafish make this a... | 18,848,866 |
The toxic effects of microcystin-LR on the reproductive system of male rats in vivo and in vitro. | The aim of this study was to investigate whether microcystin-LR, one of the most common cyanobacterial toxins has toxic effects on reproductive system in vivo or Leydig cells in vitro. Male rats were treated with MC-LR (i.p.) at a dose of 0, 5, 10 or15 microg/(kgday) for 28 days. Leydig cells were cultured with a cultu... | 18,848,877 |
Molecular evolution of the cadherin superfamily. | This review deals with the large and pleiotropic superfamily of cadherins and its molecular evolution. We compiled literature data and an in-depth phylogenetic analysis of more than 350 members of this superfamily from about 30 species, covering several but not all representative branches within metazoan evolution. We ... | 18,848,899 |
Inflammatory bowel disease in African American children compared with other racial/ethnic groups in a multicenter registry. | Few epidemiologic investigations characterize inflammatory bowel disease (IBD) in non-Caucasian children. Our study compared IBD characteristics between African Americans and non-African Americans enrolled in a multicenter pediatric IBD registry with endoscopic- and pathology-based diagnosis. The study retrieved data e... | 18,848,910 |
Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells. | Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion. Conditioned medium from Clone #3 (CM#3) strongly promoted invasion, while CM from Clone #8 (CM#8) inhibited invasion in vitro. 2D DIGE... | 18,848,913 |
Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity. | Parkinson's disease (PD) is a movement disorder caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to nigrostriatal degeneration. The inhibition of mitochondrial respiratory chain complex I and oxidative stress-induced damage have been implicated in the pathogenesis of PD. The pre... | 18,848,925 |
3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity. | 3-Methoxytyramine (3-MT), an extraneuronal metabolite of dopamine, present in the synaptic cleft at a very low amount (low nanomolar range), comparable to dopamine concentration, is generally regarded as a biologically inactive compound. We have shown in this study that 3-MT binds to the rat noradrenergic cortical alph... | 18,848,930 |
A mouse model of Clostridium difficile-associated disease. | Infection with Clostridium difficile causes nosocomial antibiotic-associated diarrhea and colitis. Hamsters historically have been used to investigate disease pathogenesis and treatment, but are not ideal models because of the lack of hamster-specific reagents and genetically modified animals, and because they develop ... | 18,848,941 |
Transient expression of a polydnaviral gene, CpBV15beta, induces immune and developmental alterations of the diamondback moth, Plutella xylostella. | The diamondback moth, Plutella xylostella, parasitized by its endoparasitoid wasp, Cotesia plutellae, undergoes various physiological alterations which include immunosuppression and an extended larval development. Its symbiotic virus, C. plutellae bracovirus (CpBV), is essential for their successful parasitization with... | 18,848,950 |
Neuromuscular electrical stimulation of the hindlimb muscles for movement therapy in a rodent model. | Neuromuscular electrical stimulation (NMES) can provide functional movements in people after central nervous system injury. The neuroplastic effects of long-term NMES-induced repetitive limb movement are not well understood. A rodent model of neurotrauma in which NMES can be implemented may be effective for such invest... | 18,848,960 |
The chicken as a natural model for extraintestinal infections caused by avian pathogenic Escherichia coli (APEC). | E. coli infections in avian species have become an economic threat to the poultry industry worldwide. Several factors have been associated with the virulence of E. coli in avian hosts, but no specific virulence gene has been identified as being entirely responsible for the pathogenicity of avian pathogenic E. coli (APE... | 18,848,980 |
Sociodemographic and behavioral predictors of bed time and wake time among US adolescents aged 15 to 17 years. | To examine bed times and wake times in US adolescents aged 15 to 17 years using time diaries to determine whether adolescent sleep has changed in recent years and what factors determine bed times and wake times. Time diary analysis using 2 national probability samples: 1981 Time Use Longitudinal Panel Study (n = 130) a... | 18,849,051 |
Effects of temporary calf removal and eCG on pregnancy rates to timed-insemination in progesterone-treated postpartum Nellore cows. | The objective was to evaluate the effects of temporary calf removal (TCR), eCG administration, or both, in a progesterone-based protocol. Suckled Nellore cows (40-80 d postpartum, n=443) with body condition scores from 2.0 to 3.5 (5-point scale) on three farms were all given a synchronizing protocol (PEPE). At the star... | 18,849,065 |
Planktonic and benthic microalgal community composition as indicators of terrestrial influence on a fringing reef in Ishigaki Island, Southwest Japan. | Microalgal-based indicators were used to assess terrestrial influence on Shiraho coral reef of Ishigaki Island (Okinawa, Japan). A typhoon occurred on 4-5 August 2005 and sampling were made on three occasions thereafter (6, 8, and 11 August). Pre-typhoon sampling was conducted on 26 July. The typhoon-enhanced terrestri... | 18,849,068 |
Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) conduits for peripheral nerve regeneration. | Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was investigated for possible application in repairing damaged nerves. Porous nerve conduits with both uniform wall porosity and non-uniform wall porosity were prepared using a particle leaching method. Adult Sprague-Dawley (SD) rats weighing 200-250 g were used as... | 18,849,069 |
Zap-70 positive chronic lymphocytic leukemia co-existing with Jak 2 V671F positive essential thrombocythemia: a common defective stem cell? | Essential thrombocythemia (ET) co-existing with chronic lymphocytic leukemia (CLL) is extremely rare. We report two cases of ET with Jak 2 V617F in Zap-70+ CLL. ET is a myeloproliferative stem cell disease. Zap-70 expression in CLL correlates with non-mutated immunoglobulin genes. The occurrence of a less mature CLL in... | 18,849,073 |
Schizotypal traits and cognitive function in healthy adults. | Growing evidence has shown that psychometrically identified schizotypes among student populations have subtle cognitive impairments in several domains such as attention, working memory and executive function, but the possible association between psychometric schizotypy in adult populations and cognitive function has no... | 18,849,081 |
Myelination progression in language-correlated regions in brain of normal children determined by quantitative MRI assessment. | To investigate the myelination progression course in language-correlated regions of children with normal brain development by quantitative magnetic resonance imaging (MRI) analysis compared with histological studies. The subjects were 241 neurologically intact neonates, infants and young children (128 boys and 113 girl... | 18,849,083 |
The extraordinary healing properties of the pediatric tympanic membrane: a study of atelectasis in the pediatric ear. | Traumatic perforations of the eardrum are generally treated conservatively as they tend to heal spontaneously. Retraction pockets of the eardrum, leading to atelectasis of the middle ear and often ultimately though unpredictably, to cholesteatoma formation, are treated in a variety of ways including complex grafting pr... | 18,849,084 |
Fine vs. coarse complete all-in-one admixture infusions over 96 hours in rats: fat globule size and hepatic function. | The United States Pharmacopeia (USP) has adopted Chapter <729> that set two globule size limits for all lipid emulsions with the mean droplet size at no >500 nm, while large-diameter fat globules as the percent fat>5 microm or PFAT(5) must be <0.05%. A quantitative risk assessment of toxicity from the in... | 18,849,096 |
High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. | Perillyl alcohol (POH) is currently in phase II clinical trials both as a chemopreventative and chemotherapeutic agent. The present report describes a simple, rapid and sensitive HPLC-UV method to quantify POH in rat plasma. After protein precipitation with acetonitrile, POH was separated using an Agilent Zorbax XDB C(... | 18,849,133 |
Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis. | To study the structure-activity relationship of coumarin (-) mammea A/BB isolated from the CH(2)Cl(2) extract of Calophyllum brasiliense leaves, we evaluated the antileishmanial activity of natural, synthetic and derivatives of this coumarin, against promastigote and intracellular amastigote forms of Leishmania amazone... | 18,849,135 |
[Outcome for adults with acute respiratory distress syndrome]. | Acute respiratory distress syndrome in adults (ARDS) is a relatively frequent disease, the mortality of which has diminished considerably in recent years. The long-term outcome of patients who have survived ARDS has been studied extensively and should in the future be taken into account in assessing new treatment modal... | 18,849,139 |
Assessment of nutritional status in free-living elderly individuals by bioelectrical impedance vector analysis. | The aim of the present research was to examine bioelectrical vector changes in relation to nutritional status in a sample of healthy free-living elderly people. The study group consisted of 170 men and women 70 to 99 y of age. Anthropometric and bioelectrical (resistance and reactance, 50 kHz, 800 muA) measurements wer... | 18,849,147 |
Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | We examined the effect of different amounts of dietary corn oil rich in linoleic acid (LA) on the endogenous synthesis of arachidonic acid (AA), uptake of its precursor LA, and fatty acid composition of tissues involved in the supply of long-chain polyunsaturated fatty acids for milk synthesis. Female Sprague Dawley ra... | 18,849,148 |
Solidification/stabilisation of air pollution control residues using Portland cement: Physical properties and chloride leaching. | Portland cement (CEMI) was used to solidify air pollution control (APC) residues from an energy-from-waste plant burning municipal solid waste. APC residue/CEMI mixes were prepared with CEMI additions ranging from 0 to 50 weight% (wt%) of total dry mass and water/solids ratios between 0.40 and 0.80. Isothermal conducti... | 18,849,156 |
Characteristics and biogas production potential of municipal solid wastes pretreated with a rotary drum reactor. | This study was conducted to determine the characteristics and biogas production potential of organic materials separated from municipal solid wastes using a rotary drum reactor (RDR) process. Four different types of wastes were first pretreated with a commercial RDR system at different retention times (1, 2 and 3 d) an... | 18,849,162 |
Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay. | We report the discovery of a series of (naphthalen-4-yl)(phenyl)methanones as potent inducers of apoptosis using our proprietary cell- and caspase-based ASAP HTS assay. Through SAR studies, a group of N-methyl-N-phenylnaphthalen-1-amines also were identified as potent inducers of apoptosis. (1-(Dimethylamino)naphthalen... | 18,849,165 |
Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells. | A series of chalcogenopyrylium dyes were evaluated as modulators/inhibitors of P-glycoprotein (Pgp). Their ability to inhibit verapamil (VER)-dependent ATPase activity (IC(50) values) in lipid-activated, mouse Cys-less mdr3 Pgp was determined. Their ability to promote calcein-AM (CAM) uptake in MDCKII-MDR1 cells and th... | 18,849,167 |
The Val allele of HER-2 codon 655 predicts the progression of oral squamous cell carcinoma. | HER-2 proto-oncogene is important for oral carcinogenesis. HER-2 codon 655 polymorphism, either isoleucine (Ile: ATC) or valine (Val: GTC), was associated with the risk of breast carcinoma. This study investigated the clinicopathological implications of this polymorphism in oral carcinoma. We found that 79% of oral car... | 18,849,186 |
99mTc(V)-dimercaptosuccinic acid scintigraphy in detecting neck metastases in oral squamous cell carcinoma with clinically negative necks. | This study compares the accuracy of 99mTc(V)-dimercaptosuccinic acid (99mTc(V)-DMSA) Single Photon Emission Computer Tomography (SPECT) by intravenous or local injection in the detection of occult cervical lymph node metastases in clinically N0 squamous cell carcinoma of the oral cavity. Fifty-eight previously untreate... | 18,849,187 |
The effect of preoperative circadian blood pressure pattern on early postoperative outcomes in patients with coronary artery bypass graft surgery. | The aim of this prospective study was to evaluate the relationship between preoperative circadian blood pressure pattern and early postoperative course in patients undergoing coronary artery bypass graft (CABG) surgery. One hundred and thirty patients planning to undergo isolated CABG operation were included to the stu... | 18,849,227 |
Genetic susceptibility, evolution and the kuru epidemic. | The acquired prion disease kuru was restricted to the Fore and neighbouring linguistic groups of the Papua New Guinea highlands and largely affected children and adult women. Oral history documents the onset of the epidemic in the early twentieth century, followed by a peak in the mid-twentieth century and subsequently... | 18,849,290 |
Trajectories and antecedents of treatment response over time in early-episode psychosis. | Little is known about the extent of heterogeneity of symptomatology in treated early-onset psychosis. The current study aims to quantify the extent of heterogeneity in trajectories of treated symptom severity in early-episode psychosis and their antecedents. Data were from 491 persons with early-episode psychosis from ... | 18,849,294 |
Comparative phylogenetic analysis of small GTP-binding genes of model legume plants and assessment of their roles in root nodules. | Small GTP-binding genes play an essential regulatory role in a multitude of cellular processes such as vesicle-mediated intracellular trafficking, signal transduction, cytoskeletal organization, and cell division in plants and animals. Medicago truncatula and Lotus japonicus are important model plants for studying legu... | 18,849,296 |
Development of sarcomas in mice implanted with mesenchymal stem cells seeded onto bioscaffolds. | Bone marrow-derived mesenchymal stem cells (MSCs) are precursors of bone, cartilage and fat tissue. MSC can also regulate the immune response. For these properties, they are tested in clinical trials for tissue repair in combination with bioscaffolds or injected as cell suspension for immunosuppressant therapy. Experim... | 18,849,298 |
Estimating co-occurring behavioral trajectories within a neighborhood context: a case study of multivariate transition models for clustered data. | Comorbidity is well-documented in psychiatric and risk behavior epidemiology. The authors present a novel application of clustered multivariate transition models to study comorbidity within a clustered context. The authors used data from the Project on Human Development in Chicago Neighborhoods (1995-2002) to assess tr... | 18,849,302 |
Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. | Galectin-3, a beta-galactoside binding, endogenous lectin, takes part in various inflammatory events and is produced in substantial amounts at inflammatory foci. We investigated whether extracellular galectin-3 could participate in the phagocytic clearance of apoptotic neutrophils by macrophages, a process of crucial i... | 18,849,325 |
Ventricular activation is impaired in aged rat hearts. | Ventricular arrhythmias are frequently observed in the elderly population secondary to alterations of electrophysiological properties that occur with the normal aging process of the heart. However, the underlying mechanisms remain poorly understood. The aim of the present study was to determine specific age-related cha... | 18,849,337 |
Dialogical nursing ethics: the quality of freedom restrictions. | This article deals with the question of how ethicists respond to practical moral problems emerging in health care practices. Do they remain distanced, taking on the role of an expert, or do they become engaged with nurses and other participants in practice and jointly develop contextualized insights about good care? A ... | 18,849,368 |
Producing and using genetic evaluations in the United States beef industry of today. | The overall motivation for the development of an information system for beef cattle improvement is the belief that knowledge of breeding values and heterosis effects allows one to determine the consequences of alternative selection and mating options. With this information, livestock managers can easily shift populatio... | 18,849,385 |
Performance and carcass traits of finishing heifers fed crude glycerin. | Crossbred heifers (n = 373; 421.6 kg +/- 28.9) were fed finishing diets containing 0, 2, 4, 8, 12, or 16% crude glycerin (DM basis). Diets consisted of steam-flaked corn with 6% alfalfa hay and 1.2% urea and provided 300 mg of monensin, 90 mg of tylosin, and 0.5 mg of melengestrol acetate per animal daily. Cattle were ... | 18,849,392 |
Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of response. | Data examining the role of pulmonary rehabilitation (PR) in interstitial lung disease (ILD) are limited. We tested the hypothesis that PR can improve functional status and dyspnea in a large group of patients with ILD, and that certain baseline patient variables can predict this improvement. Data from patients who were... | 18,849,399 |
Arm span to height ratio is related to severity of dyspnea, reduced spirometry volumes, and right heart strain. | Arm span is the closest physiologic measurement to standing height. Increased arm span to standing height ratio, therefore, indicates possible loss of height, which is a feature of aging, often resulting from osteoporosis-related vertebral collapse. We hypothesize that the discrepancy between arm span and height is ass... | 18,849,402 |
Brain natriuretic peptide levels in managing pediatric patients with pulmonary arterial hypertension. | Pulmonary arterial hypertension (PAH) is an important determinant of morbidity and mortality in children. In this study, we aimed to investigate the value of brain natriuretic peptide (BNP) in a cohort of children with PAH, with respect to monitoring disease severity as assessed by hemodynamic and echocardiographic par... | 18,849,405 |
Flexible fitting of high-resolution x-ray structures into cryoelectron microscopy maps using biased molecular dynamics simulations. | A methodology for flexible fitting of all-atom high-resolution structures into low-resolution cryoelectron microscopy (cryo-EM) maps is presented. Flexibility of the modeled structure is simulated by classical molecular dynamics and an additional effective potential is introduced to enhance the fitting process. The add... | 18,849,406 |
Finding and characterizing tunnels in macromolecules with application to ion channels and pores. | We describe a new algorithm, CHUNNEL, to automatically find, characterize, and display tunnels or pores in proteins. The correctness and accuracy of the algorithm is verified on a constructed set of proteins and used to analyze large sets of real proteins. The verification set contains proteins with artificially create... | 18,849,407 |
The structural impact of a polyglutamine tract is location-dependent. | Polyglutamine (polyQ) expansion leads to protein aggregation and neurodegeneration in Huntington's disease and eight other inherited neurological conditions. Expansion of the polyQ tract beyond a threshold of 37 glutamines leads to the formation of toxic nuclear aggregates. This suggests that polyQ expansion causes a c... | 18,849,414 |
The Biosynthetic pathway for synechoxanthin, an aromatic carotenoid synthesized by the euryhaline, unicellular cyanobacterium Synechococcus sp. strain PCC 7002. | The euryhaline, unicellular cyanobacterium Synechococcus sp. strain PCC 7002 produces the dicyclic aromatic carotenoid synechoxanthin (chi,chi-caroten-18,18'-dioic acid) as a major pigment (>15% of total carotenoid) and when grown to stationary phase also accumulates small amounts of renierapurpurin (chi,chi-caroten... | 18,849,428 |
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