title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Bacterial flagella are firmly anchored. | There are mutants of Salmonella enterica (with mutations in fliF and fliL) that shed flagella when they are swimming in a viscous medium or on the surface of soft agar. Filaments with hooks and the distal rod segment FlgG are recovered. We tried to extract flagellar filaments from such cells by pulling on them with an ... | 18,849,436 |
Volatilization and precipitation of tellurium by aerobic, tellurite-resistant marine microbes. | Microbial resistance to tellurite, an oxyanion of tellurium, is widespread in the biosphere, but the geochemical significance of this trait is poorly understood. As some tellurite resistance markers appear to mediate the formation of volatile tellurides, the potential contribution of tellurite-resistant microbial strai... | 18,849,455 |
Differential expression in Phanerochaete chrysosporium of membrane-associated proteins relevant to lignin degradation. | Fungal lignin-degrading systems likely include membrane-associated proteins that participate in diverse processes such as uptake and oxidation of lignin fragments, production of ligninolytic secondary metabolites, and defense of the mycelium against ligninolytic oxidants. Little is known about the nature or regulation ... | 18,849,459 |
Noncontact ultrasound therapy for adjunctive treatment of nonhealing wounds: retrospective analysis. | The optimal adjunctive therapy for wounds that fail to heal despite conventional wound care has not been established. Clinical evidence suggests improved healing in wounds treated with noncontact ultrasound therapy (NCUT). Although existing evidence supports the use of NCUT for enhanced wound healing, the total number ... | 18,849,480 |
Deleterious role of TLR3 during hyperoxia-induced acute lung injury. | Acute respiratory distress syndrome (ARDS) manifests clinically as a consequence of septic and/or traumatic injury in the lung. Oxygen therapy remains a major therapeutic intervention in ARDS, but this can contribute further to lung damage. Patients with ARDS are highly susceptible to viral infection and it may be due ... | 18,849,495 |
High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling. | Phosphate (Pi) is an essential nutrient to living organisms. Recent surveys indicate that the intake of Pi has increased steadily. Our previous studies have indicated that elevated Pi activates the Akt signaling pathway. An increased knowledge of the response of lung cancer tissue to high dietary Pi may provide an impo... | 18,849,498 |
Gradual loss of homelikeness in exhaustion disorder. | Our aim with the present study was to explore the lived experiences of the process leading to exhaustion. Within a hermeneutic phenomenological perspective, semistructured interviews were conducted with eleven individuals on sick leave because of exhaustion disorder. The findings were interpreted as a process of five s... | 18,849,512 |
Contradictions and misperceptions: an exploration of injecting practice, cleanliness, risk, and partnership in the lives of women drug users. | We report the findings of an in-depth interview study conducted with 45 women injecting drug users in Britain. Women described experiences of injecting themselves and being injected by others, including instances of bodily harm and pain. Cleanliness when injecting was an issue of particular importance. An interesting d... | 18,849,514 |
Multidisciplinary, interdisciplinary, or dysfunctional? Team working in mixed-methods research. | Combining qualitative and quantitative methods in a single study-otherwise known as mixed-methods research-is common. In health research these projects can be delivered by research teams. A typical scenario, for example, involves medical sociologists delivering qualitative components and researchers from medicine or he... | 18,849,518 |
Schizophrenia patients lack normal positive correlation between age and brain response during verbal learning. | To investigate the differences in the relationship of age to brain function among individuals with schizophrenia and a healthy comparison group. The authors hypothesized that the correlation with age would be more strongly negative among schizophrenia patients, particularly in the frontal cortex. Cross-sectional measur... | 18,849,533 |
Timing of Egf treatment differentially affects Tgf-beta2 induced cranial suture closure. | Premature suture obliteration results in an inability of cranial and facial bones to grow, with craniofacial dysmorphology requiring surgical correction as a consequence. Understanding signaling pathways associated with suture morphogenesis might enable non-invasive treatment of patients with fused sutures. Tgf-beta 2 ... | 18,849,541 |
Regulatory agency consideration of pharmacogenomics. | This article discusses the current ambiguous state of federal regulatory agency control over pharmacogenomic testing, a subset of genetic testing that combines information about genetic variability with pharmacology in order to improve drug recommendations. An analysis of the common three terms used to evaluate regulat... | 18,849,547 |
Characteristics of thiamin and its relevance to the management of heart failure. | Heart failure (HF) is a major public health problem in the United States that puts a significant burden on both patients and the healthcare system. The prevalence of malnutrition in HF patients is well-known and correlates with a dramatic decline in quality of life and disease progression, and is associated with high m... | 18,849,553 |
Degradation of sphingoid long-chain base 1-phosphates (LCB-1Ps): functional characterization and expression of AtDPL1 encoding LCB-1P lyase involved in the dehydration stress response in Arabidopsis. | Sphingoid long-chain base (LCB) 1-phosphates are degradated by LCB 1-phosphate lyase to C(16) fatty aldehydes and phosphoethanolamine. Here, we confirmed that the At1g27980 gene product, AtDPL1, is a functional LCB-1-phosphate lyase. Expression of green fluorescent protein fusion products in suspension-cultured Arabido... | 18,849,574 |
Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection. | Coxsackievirus B3 (CVB3) is known to cause a variety of human diseases including acute and chronic myocarditis as well as dilated cardiomyopathy (DCM). However, the mechanisms by which CVB3 causes diseases are not well understood. Studies identifying protein-protein interactions during CVB3 infection are useful in deli... | 18,849,585 |
New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. | The heterotetrameric phosphodiesterase (PDE) 6 complex, made up of alpha, beta and two gamma subunits, regulates intracellular cGMP levels by hydrolyzing cGMP in response to light activation of G protein coupled receptors in cones and rods, making it an essential component of the visual phototransduction cascade [Zhang... | 18,849,587 |
Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes. | Previous results demonstrated that sensitization to specific olive pollen allergens could be related with a different clinical pattern (asthma and/or rhinitis), and that specific patterns of sensitization are regulated by different HLA class II antigens. The authors analyze the possible implication of 7 genetic polymor... | 18,849,614 |
The molecular interactions between filtered proteins and proximal tubular cells in proteinuria. | Proteinuria is associated with progressive chronic kidney disease and poor cardiovascular outcomes. Exposure of proximal tubular epithelial cells to excess proteins leads to the development of proteinuric nephropathy with tubular atrophy, interstitial inflammation and scarring. Numerous signalling pathways are activate... | 18,849,618 |
Values for macular perimetry using the MP-1 microperimeter in normal subjects. | To establish values for the fixation pattern and macular sensitivity to light in healthy subjects using the MP-1 microperimeter (Nideck Technologies, Vigonza, Italy). A prospective study of 37 healthy subjects (age: 19-71 years), approved by the institutional review board. Full-threshold microperimetry of the central 1... | 18,849,636 |
Long-term survival and prognostic indicators in small (<or=2 cm) pancreatic cancer. | In a matched analysis, we investigated clinical, histopathological, and survival characteristics of small (<or=2 cm) pancreatic cancer (PaC) as compared to large PaC. From the Mayo pathology database, we identified 41 consecutive patients with small PaC and 94 matched controls with margin-negative PaC >2 cm. Two ... | 18,849,640 |
Application of a global proteomic approach to archival precursor lesions: deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancer precursors. | Pancreatic cancer is an almost uniformly fatal disease, and early detection is a critical determinant of improved survival. A variety of noninvasive precursor lesions of pancreatic adenocarcinoma have been identified, which provide a unique opportunity for intervention prior to onset of invasive cancer. Biomarker disco... | 18,849,643 |
Next generation of human vaccines: what does the future hold? | The World Vaccine Congress was held in Arlington, VA April 21st-24th, 2008. Tevi Troy, the deputy secretary of the US Department of Health and Human Services, set the tone of the meeting during his keynote address. He discussed the government's plan to deliver a strategic outlook and follow a road map for vaccine devel... | 18,849,649 |
Subtype-selective conopeptides targeted to nicotinic receptors: Concerted discovery and biomedical applications. | Conus peptides that are selectively targeted to different molecular isoforms of nicotinic acetylcholine receptors (nAChRs) have been identified and characterized; several have recently been shown to have significant biomedical potential. An emerging strategy for the discovery from animal biodiversity of subtype-specifi... | 18,849,660 |
Fourth Annual Warren K. Sinclair Keynote Address: the use and misuse of radiation in medicine. | Among the many diagnostic and therapeutic uses of ionizing radiation in medicine, the potential for misuse is greatest in diagnostic imaging, particularly with computed tomography. While several technical adjustments may be made to produce a dose that is as low as reasonably achievable, appropriate utilization of these... | 18,849,681 |
Update on linear non-threshold dose-response model and implications for diagnostic radiology procedures. | Cancer risk estimates are used in the setting of radiation protection standards by international and national organizations, and for this purpose need to be developed for low doses of radiation. The approach has involved extrapolation from cancer mortality and incidence values at higher doses to predict the low-dose es... | 18,849,687 |
Research involving human subjects. | This paper will discuss the history of human subjects in research and the subsequent regulations and requirements that now govern human subject research. Also presented are the requirements and definitions of the oversight bodies which govern human use research in the United States. | 18,849,688 |
Digital radiography: image quality and radiation dose. | Digital radiography devices, rapidly replacing analog screen-film detectors, are now common in diagnostic radiological imaging, where implementation has been accelerated by the commodity status of electronic imaging and display systems. The shift from narrow latitude, fixed-speed screen-film detectors to wide latitude,... | 18,849,693 |
Technical advances of interventional fluoroscopy and flat panel image receptor. | In the past decade, various radiation reducing devices and control circuits have been implemented on fluoroscopic imaging equipment. Because of the potential for lengthy fluoroscopic procedures in interventional cardiovascular angiography, these devices and control circuits have been developed for the cardiac catheteri... | 18,849,699 |
Dose to normal tissues outside the radiation therapy patient's treated volume: a review of different radiation therapy techniques. | Radiation therapy treatment planning and delivery capabilities have changed dramatically since the introduction of three-dimensional treatment planning and are continuing to change relatively rapidly in response to the implementation of new advanced technologies. Three-dimensional conformal radiation therapy (3DCRT) is... | 18,849,701 |
A robotic manipulator for handling TLD badges. | A prototype system for automatic handling of Harshaw/Bicron (now ThermoFisher Scientific) thermoluminescent dosimetry (TLD) badges, which is based on a robotic arm, was designed and built. The robot performs the loading and unloading of the TLD cards in the badges and transports them between the loading/unloading stati... | 18,849,713 |
An evidence-based protocol for nurse retention. | Registered nurse turnover can drastically affect the quality of patient care while costing more than 1 billion dollars. The ongoing nursing shortage makes it hard to replace nurses, necessitating a novel approach to reduce nurse turnover. The authors discuss an evidence-based protocol that improves organizational commi... | 18,849,749 |
The prevalence of metabolic syndrome in an employed population and the impact on health and productivity. | To investigate the prevalence of metabolic syndrome in an employed population and its association with health risks, health perception, illness days, work limitation (presenteeism), and short-term disability (STD). Five thousand five hundred twelve employees of a financial services company responded to an on-site healt... | 18,849,759 |
NACCHO helps local health departments adapt to the ever-changing field of environmental health. | The National Association of County and City Health Officials (NACCHO) is the national organization representing local health departments. NACCHO supports efforts that protect and improve the health of all people and all communities by promoting national policy, developing resources and programs, seeking health equity, ... | 18,849,783 |
Injuries from roadside improvised explosive devices. | After the invasion of Iraq in April 2003, coalition forces have remained in the country in a bid to maintain stability and support the local security forces. The improvised explosive device (IED) has been widely used by the insurgents and is the leading cause of death and injury among Coalition troops in the region. Fr... | 18,849,810 |
Nutrition consumption of female combat recruits in army basic training. | The Karakal is an existing light infantry unit consisting of both female and male fighters (predominantly female). This was the first Israel Defense Forces study to assess and to evaluate the dietary intake among male and female recruit fighters in comparison to nonfighters from preinduction through Army Basic Training... | 18,849,866 |
Overuse injuries in female infantry recruits during low-intensity basic training. | The purpose of this prospective study was to investigate the epidemiology of overuse injuries and to identify common risk factors for stress fractures among female and male recruits in a new light infantry basic training designed to minimize the incidence of overuse injuries. Study subjects were male and female recruit... | 18,849,872 |
Chronic morphine application is protective against cell death in primary human neurons. | Morphine addiction has become a long-time, serious medical and social problem. To understand the cellular mechanisms of morphine application and addiction, the effects of chronic morphine treatments were examined in primary cultured human neurons. Our results show that, surprisingly, morphine protects cultured human ne... | 18,849,879 |
A review on quality of life and depression in obsessive-compulsive disorder. | Quality of life (QoL) is increasingly recognized as a pivotal outcome parameter in research on obsessive-compulsive disorder (OCD). While the concept remains somewhat ill-defined, there is now little dispute that the patients' personal goals deserve foremost consideration during the course of treatment as the primary a... | 18,849,907 |
Subclinical obsessive-compulsive disorder in children and adolescents: additional results from a "high-risk" study. | The concept of subclinical obsessive-compulsive disorder is explored using data from a "high-risk" study of offspring of persons with (OCD) and offspring of controls. Offspring with OCD were compared to those with subclinical OCD, and those without either condition. Subclinical OCD is defined as the presence of obsessi... | 18,849,913 |
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. | Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes, controls degradation of long-lived proteins, insoluble protein aggregates and invading microbes, and is suggested to be inv... | 18,849,965 |
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. | The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here we report the systematic... | 18,849,971 |
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. | Ectopic expression of defined sets of genetic factors can reprogram somatic cells to induced pluripotent stem (iPS) cells that closely resemble embryonic stem (ES) cells. The low efficiency with which iPS cells are derived hinders studies on the molecular mechanism of reprogramming, and integration of viral transgenes,... | 18,849,973 |
Millisecond-scale differences in neural activity in auditory cortex can drive decisions. | Neurons in the auditory cortex can lock to the fine timing of acoustic stimuli with millisecond precision, but it is not known whether this precise spike timing can be used to guide decisions. We used chronically implanted microelectrode pairs to stimulate neurons in the rat auditory cortex directly and found that rats... | 18,849,984 |
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. | We used conditional knockout strategies in mice to determine the developmental events and gene expression program regulated by the LIM-homeodomain factor Islet1 in developing sensory neurons. Early development of the trigeminal and dorsal root ganglia was grossly normal in the absence of Islet1. From E12.5 onward, howe... | 18,849,985 |
Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. | RUNX3 is a tumor suppressor that is silenced in cancer following hypermethylation of its promoter. The effects of hypoxia in tumor suppressor gene (TSG) transcription are largely unknown. Here, we investigated hypoxia-induced silencing mechanisms of RUNX3. The expression of RUNX3 was downregulated in response to hypoxi... | 18,850,007 |
Immunogenic disparities of 11 minor histocompatibility antigens (mHAs) in HLA-matched unrelated allogeneic hematopoietic SCT. | We determined the alleles of 11 mHAs and investigated the association of immunogenic mHA mismatches between a donor and a recipient with a course of allogeneic hematopoietic SCT (allo-HSCT) from 10/10 alleles HLA-matched unrelated donors in 92 recipients after myeloablative conditioning between 2004 and 2006. The frequ... | 18,850,018 |
Daclizumab as useful treatment in refractory acute GVHD: a paediatric experience. | GVHD remains a serious complication after allogeneic SCT. We describe 13 paediatric patients treated with daclizumab for refractory acute GVHD (aGVHD). After 30 days of daclizumab administration, all patients with cutaneous aGVHD reached complete response. Among patients with gastrointestinal disease, 50 and 30% had co... | 18,850,021 |
Lethal limb ischaemia in leukaemia. Case report and review of the literature. | Several disturbances of the coagulation system are associated with malignancies of the hematopoietic system. The primary mechanisms of these are disseminated intravascular coagulation and hyperviscosity. As such, bleeding or thrombotic events are often encountered and, occasionally, they may even be the inaugural sympt... | 18,850,069 |
Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. | The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of human cardiovascular disease are not known. We investigated the degree to which cardiovascular disease develops in mice following subchronic TCDD exposure. Adult male C57BL/6 mice were dosed with vehicle or 300 ng TCDD/kg by o... | 18,850,075 |
Sex identification in female crayfish is bimodal. | Sex identification has been studied in several species of crustacean decapods but only seldom was the role of multimodality investigated in a systematic fashion. Here, we analyse the effect of single/combined chemical and visual stimuli on the ability of the crayfish Procambarus clarkii to identify the sex of a conspec... | 18,850,080 |
A novel patatin-like protein from cotton plant, GhPat1, is co-expressed with GhLox1 during Xanthomonas campestris-mediated hypersensitive cell death. | In cotton plant, Xanthomonas-induced hypersensitive response (HR) is accompanied by a lipid peroxidation process involving a 9-lipoxygenase (LOX), GhLox1. Initiation of this oxidative metabolism implies the release of the LOX substrates, or polyunsaturated fatty acids. Since patatin-like proteins (PLPs) are likely cand... | 18,850,102 |
Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men. | ATP-binding cassette hetero-dimeric transporters G5 and G8 (ABCG5/G8) have been postulated to mediate intestinal cholesterol efflux, whereas Niemann-Pick C1 Like 1 (NPC1L1) protein is believed to be essential for intestinal cholesterol influx. The individual or combined genetic markers, such as single nuclear polymorph... | 18,850,127 |
Adverse effects of vitamin E by induction of drug metabolism. | Observational studies with healthy persons demonstrated an inverse association of vitamin E with the risk of coronary heart disease or cancer, the outcome of large-scale clinical trials conducted to prove a benefit of vitamin E in the recurrence and/or progression of such disease, however, was disappointing. Vitamin E ... | 18,850,180 |
Effect of genistein on cholesterol metabolism-related genes in a colon cancer cell line. | The major soy-derived isoflavones such as genistein has been demonstrated to possess anticarcinogenic activity in animal model systems. The present study was designed to investigate the effects of isoflavone genistein exposure at concentrations ranging from 0.01 to 50 muM on the LDL receptor and HMG-CoA reductase gene ... | 18,850,198 |
Nutrition, sirtuins and aging. | Beyond our inherited genetic make-up environmental factors are central for health and disease and finally determine our life span. Amongst the environmental factors nutrition plays a prominent role in affecting a variety of degenerative processes that are linked to aging. The exponential increase of non-insulin-depende... | 18,850,202 |
Harnessing Nutrigenomics: Development of web-based communication, databases, resources, and tools. | Nutrient - gene interactions are responsible for maintaining health and preventing or delaying disease. Unbalanced diets for a given genotype lead to chronic diseases such as obesity, diabetes, cardiovascular, and are likely to contribute to increased severity and/or early-onset of many age-related diseases. Many nutri... | 18,850,216 |
Genes involved in obesity: Adipocytes, brain and microflora. | The incidence of obesity and related metabolic disorders such as cardiovascular diseases and type 2 diabetes, are reaching worldwide epidemic proportions. It results from an imbalance between caloric intake and energy expenditure leading to excess energy storage, mostly due to genetic and environmental factors such as ... | 18,850,214 |
The Znt4 mutation inlethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters. | The lethal milk mouse syndrome is caused by a point mutation in the zinc transporter gene ZnT4 resulting in defective zinc secretion in the milk of homozygous mutant dams. Pups of any genotype fed solely on lm milk die within the first two weeks of neonatal life, displaying zinc deficiency symptoms. Homozygous mutant p... | 18,850,221 |
Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B. | Numerous studies have shown that the levels of matrix metalloproteinase (MMP)-2 and/or MMP-9 are associated with the invasive phenotypes of cancer cells. This study investigated the effects of caffeic acid phenethyl ester (CAPE), a chemopreventive phytochemical derived from honeybee propolis, on the invasive phenotype ... | 18,850,224 |
Extracts of Rehmanniae radix, Ginseng radix and Scutellariae radix improve glucose-stimulated insulin secretion and beta-cell proliferation through IRS2 induction. | Recent studies have revealed that beta-cell dysfunction is an important factor in developing type 2 diabetes. beta-cell dysfunction is related to impairment of the insulin/IGF-1 signaling cascade through insulin receptor substrate-2 (IRS2). The induction of IRS2 in beta-cells plays an important role in potentiating bet... | 18,850,229 |
Severe tricuspid valve stenosis secondary to pacemaker leads presenting as ascites and liver dysfunction: a complex problem requiring a multidisciplinary therapeutic approach. | Tricuspid stenosis secondary to ventricular pacemaker leads is uncommon. We present a unique case of iatrogenic tricuspid stenosis secondary to fusion of the valve leaflets to transvenous implanted pacing leads. This occurred in an adult with childhood repaired Tetralogy of Fallot and high grade surgical heart block fo... | 18,850,261 |
United States-Mexico border crossing: experiences and risk perceptions of undocumented male immigrants. | Undocumented immigrants crossing the US-Mexico border face many hazards as they attempt to enter the United States, including heat and cold injury, dehydration, and wild animal encounters. In the Tucson sector of the US-Mexico border, there are over 100 deaths a year from heat-related injuries alone. Public awareness c... | 18,850,270 |
Spatial succession modeling of biological communities: a multi-model approach. | Strong spatial correlation may exist in the spatial succession of biological communities, and the spatial succession can be mathematically described. It was confirmed by our study on spatial succession of both plant and arthropod communities along a linear transect of natural grassland. Both auto-correlation and cross-... | 18,850,283 |
Analysis of mosses and topsoils for detecting sources of heavy metal pollution: multivariate and enrichment factor analysis. | In order to assess the contribution of emission sources to the pollution of areas remote from industrial facilities, a combined approach of enrichment factor analysis and multivariate statistics was used for detecting the origin of heavy metal pollution in the Zlatibor ecosystem, in Serbia. Samples of moss (Pleurozium ... | 18,850,291 |
Determination of toxic inorganic elements pollution in ground waters of Kahuta Industrial Triangle Islamabad, Pakistan using inductively coupled plasma mass spectrometry. | The present study deals with the ground water quality assessment in Kahuta Industrial Triangle Islamabad, Pakistan. The objective of the study was to assess ground water quality against the drinking water standards for various toxic inorganic elements. Representative groundwater samples were collected and analyzed in t... | 18,850,292 |
Effect of hypotensive challenge on systemic hemodynamics and cerebral blood flow in persons with tetraplegia. | Individuals with tetraplegia have impaired central control of sympathetic vascular modulation and blood pressure (BP); how this impairment affects cerebral blood flow (CBF) is unclear. To determine if persons with tetraplegia maintain CBF similarly to able-bodied controls after a hypotensive challenge. Seven individual... | 18,850,311 |
3-pentanol: a new attractant present in volatile emissions from the ambrosia beetle, Megaplatypus mutatus. | Megaplatypus mutatus (=Platypus mutatus) (Coleoptera: Platypodidae) is an ambrosia beetle that is native to South America. It attacks only standing live trees and causes severe stem breakage and death in commercial poplar (Populus) plantations. Previous work showed that male M. mutatus emits a sex pheromone composed ma... | 18,850,328 |
Working memory performance following paediatric traumatic brain injury. | The present study investigated working memory ability in children who sustained moderate-to-severe traumatic brain injuries in relation to pre-injury, injury-related and developmental factors. It was hypothesized that there would be a correlation between performance- and rater-based working memory measures; factors pre... | 18,850,343 |
Effect of modified constraint-induced movement therapy on lower extremity hemiplegia due to a higher-motor area lesion. | Modified CIT (mCIT) was performed in a stroke patient with a lesion in the left medial frontal region including the supplementary motor area (SMA), which is part of the higher-motor area, and whose primary symptom was motor ignition difficulty observed at the start of voluntary movement of the right leg. mCIT was perfo... | 18,850,348 |
Aquasomes--a nanoparticulate approach for the delivery of antigen. | The development of compound that enhances immune responses to recombinant or synthetic epitopes is of considerable importance in vaccine research. Of the many different types of immunopotentiating compounds that have been researched, aquasomes are of considerable promise, because of their potency and adjuvanticity. Aqu... | 18,850,363 |
Lung tissue storage: optimizing conditions for future use in molecular research. | The quality of tissue studied impacts greatly on oligonucleotide microarray results, emphasizing the importance of harvesting techniques. The analyzed RNA extracted from human lung samples preserved via 4 different storage conditions (RNAlater, phosphate-buffered saline, TRIzol, liquid nitrogen). RNA was assessed by de... | 18,850,373 |
The role of religiosity, religious norms, subjective norms, and bodily integrity in signing an organ donor card. | This article examines the influence of religiosity, religious norms, subjective norms, and bodily integrity (the extent to which people think the body should remain unaltered after death) on intent to donate organs postmortem. A total of 4,426 participants from 6 universities completed surveys for this study. The resul... | 18,850,391 |
Effects of risk-focused and recommendation-focused mental imagery on occupational risk communication. | This study examined the impact of mental imagery instructions in a National Institute for Occupational Safety and Health (NIOSH) safety document conveying risk and safety information to farmers. A sample of 314 farmers recruited from a large Southeastern state fair was randomly assigned to conditions in a 2 x 2 design.... | 18,850,394 |
Formal semantics of guarded task structures for clinical practice guidelines. | In many of the clinical practice guidelines, the process of delivering health care is only implicitly or vaguely defined. An explicit model of the medical tasks involved in this process is needed before active clinical decision support for the patient encounter can be provided. We propose task diagrams as a structured,... | 18,850,401 |
Bariatric surgery in paediatrics--when and how? | Morbid obesity and its rapidly increasing prevalence has became a serious health, social and economic problem not only in Europe, but in other developed countries in the Western world. It is well recognized that conservative treatment usually fails in morbidly obese patients in the long-term. In severely obese patients... | 18,850,407 |
Sticks and stones may break my bones: work-related orthopaedic injuries sustained during obstetrics and gynaecology training. | Backache is a common cause of morbidity among doctors and 50% of the obstetricians and gynaecologists suffering from this attribute it to work practice and posture. Occupational injuries remain poorly studied among obstetricians and gynaecologists and we have therefore tried to assess the extent and demographics of wor... | 18,850,418 |
Exposure to ultrafine particles in asphalt work. | An epidemiologic study has demonstrated that asphalt workers show increased loss of lung function and an increase of biomarkers of inflammation over the asphalt paving season. The aim of this study was to investigate which possible agent(s) causes the inflammatory reaction, with emphasis on ultrafine particles. The wor... | 18,850,455 |
Spatial variability of ambient nitrogen dioxide and sulfur dioxide in Sarnia, "Chemical Valley," Ontario, Canada. | This study aimed at developing models to predict nitrogen dioxide (NO(2)) and sulfur dioxide (SO(2)) concentrations in Sarnia, "Chemical Valley", Ontario, Canada, and model the intra-urban variation of ambient NO(2) and SO(2) in the city for a community health study. NO(2) and SO(2) samples were monitored with Ogawa pa... | 18,850,457 |
Transgenic mice expressing cyan fluorescent protein as a reporter strain to detect the effects of rotenone toxicity on retinal ganglion cells. | This is the first study using a reporter transgenic model to investigate the effects of an environmental toxin on the retina. Rotenone is a widely used pesticide that inhibits mitochondrial complex I and produces neurotoxicity. Previous studies demonstrated the time course and dose response of rotenone toxicity on reti... | 18,850,458 |
Exposure assessment and risk of gastrointestinal illness among surfers. | Surfing is a unique recreational activity with the possibility of elevated risk for contracting gastrointestinal (GI) illness through ingestion of contaminated water. No prior studies have assessed exposure from ingestion among surfing populations. This study estimated the magnitude and frequency of incidental water in... | 18,850,460 |
Pareidolias in obsessive-compulsive disorder: neglected symptoms that may respond to serotonin reuptake inhibitors. | Obsessive-compulsive disorder (OCD) is a multifaceted and treatable condition. We describe a patient with OCD whose main complaint was the experience of pareidolias (i.e., 'images seen out of shapes'), a symptom that responded to treatment with a serotonin reuptake inhibitor. Single case report. Mrs A, a 38-year-old ma... | 18,850,462 |
Evaluation of glucose homeostasis in transfusion-dependent thalassemic patients. | Diabetes is an important problem encountered in thalassemic patients. The severity and type of glucose disturbances vary greatly in different studies. Also the pathogenesis seems to be complex; either insulin deficiency or insulin resistance may mediate the glucose disturbances. In a group of thalassemic patients gluco... | 18,850,475 |
Vaginal clear cell adenocarcinoma with early pulmonary metastasis in a child. | Although a few cases of vaginal clear cell adenocarcinoma (CCAC) have been reported in the ages under 14, they have presented in a much more aggressive form than the CCAC cases in higher ages and parenchymal pulmonary metastasis are known to occur following the primary tumor. This is a case report of a primary vaginal ... | 18,850,481 |
Modulation of in vivo oxidative status by exogenous corticosterone and restraint stress in rats. | Physical and psychological stressors not only enhance activity of the hypothalamo-pituitary-adrenocortical axis, but also cause oxidative damage by inducing an imbalance between the in vivo pro-oxidant and antioxidant status. The involvement of adrenal steroid stress hormones in oxidative damage associated with these s... | 18,850,490 |
Urinary cortisol responses to unusual events in captive chimpanzees (Pan troglodytes). | This study investigated the urinary cortisol stress response to one known stressor (anaesthesia) and three unusual events hypothesized to result in increases in cortisol (confinement to one half of an enclosure for several days due to a hurricane, an enrichment exercise, and a change in group composition) in young chim... | 18,850,493 |
[A challenge in spite of acceptance - how mothers of newborn babies with a "cleft" experience the transition from the hospital back home]. | There is almost no empirical data about how mothers of newborn babies with a cleft lip and/or palate manage the transition from the hospital to home. This qualitative study therefore focuses on the experiences of mothers of newborn babies with a cleft lip and palate. Two problem-oriented interviews were conducted with ... | 18,850,534 |
[Nurses' perspective on interprofessional communication on an intensive care unit]. | The aim of this qualitative study was to explore experience in nurses' interdisciplinary/interprofessional communication on an intensive care unit. The structure of communication and influencing factors were shown and interpreted from the perspective of the nurses. Nurses working on an internal medical intensive care u... | 18,850,538 |
Oxidative stress intensity in lens and aqueous depending on age-related cataract type and brunescense. | Cataract formation represents a serious problem in the elderly, and has a large impact on healthcare budget. The oxidative stress form and intensity might determine the cataract type and pigmentation, making efforts in the cataract prevention challenge more complex. This is a retrospective cross-sectional review of 80 ... | 18,850,540 |
Amniotic membrane transplantation: indications and results. | To describe amniotic membrane transplantation indications and results at the authors' institution. In this study, chart review of 108 patients who underwent amniotic membrane transplantation between January 2002 and April 2006 was performed. The survival rate of corneal integrity was compared, using Kaplan-Meier surviv... | 18,850,543 |
Post-trabeculectomy choroidal detachment: not an adverse prognostic sign for either visual acuity or surgical success. | To report the incidence of choroidal detachment (CD) following trabeculectomy and to evaluate its effect on long-term surgical success and best-corrected visual acuity (BCVA). A total of 253 eyes of 198 subjects who underwent trabeculectomy between 1993 and 2003 with at least 1 year follow-up were reviewed retrospectiv... | 18,850,557 |
Intravenous diclofenac as prophylactic treatment for verteporfin-associated low back pain. | The authors report on the therapeutic effect of intravenous diclofenac on verteporfin associated low back pain (LBP), which is the most frequent adverse effect of photodynamic therapy (PDT) for macular degeneration. The authors studied 818 patients who received PDT with verteporfin for choroidal neovascularization. Sys... | 18,850,562 |
Effective treatment with topical cyclosporine of a child with steroid-dependent interstitial keratitis. | To report a case of steroid-dependent idiopathic interstitial keratitis in a child successfullytreated with topical cyclosporine 2% drops. Case report. The authors describe a case of a 6-year-old boy with a history of recurrent idiopathic bilateral interstitial keratitis. The patient had recurrent episodes of corneal i... | 18,850,565 |
Japanese medaka Hox paralog group 2: insights into the evolution of Hox PG2 gene composition and expression in the Osteichthyes. | Hox paralog group 2 (PG2) genes function to specify the development of the hindbrain and pharyngeal arch-derived structures in the Osteichthyes. In this article, we describe the cDNA cloning and embryonic expression analysis of Japanese medaka (Oryzias latipes) Hox PG2 genes. We show that there are only two functional ... | 18,850,588 |
Fetal death persists through recurrent pregnancies in mice following Ljungan virus infection. | Laboratory mice infected with Ljungan virus (LV) early in pregnancy suffer from perinatal death. Here we investigate the persistence of that effect through the outcome of consecutive pregnancies in LV-infected mice. CD-1 mice were infected while pregnant and their adult female offspring were followed in parallel with u... | 18,850,589 |
3- Instead of 4-helix formation in a de novo designed protein in solution revealed by small-angle X-ray scattering. | De novo design and chemical synthesis of proteins and their mimics are central approaches for understanding protein folding and accessing proteins with novel functions. We have previously described carbohydrates as templates for the assembly of artificial proteins, so-called carboproteins. Here, we describe the prepara... | 18,850,602 |
Cobalt- and nickel-catalyzed regio- and stereoselective reductive coupling of alkynes, allenes, and alkenes with alkenes. | Transition-metal-catalyzed coupling of two different C-C pi components through a metallacycle intermediate is a highly atom economical method to construct C-C bonds in organic synthesis. The metal-catalyzed coupling of an alkene and alkyne generally gives an Alder-ene or reductive coupling product. In this article, we ... | 18,850,608 |
Acceleration effect of an allylic hydroxy group on ring-closing enyne metathesis of terminal alkynes: scope, application, and mechanistic insights. | An interesting acceleration effect of an allylic hydroxy group on ring-closing enyne metathesis has been found. Ring-closing enyne metathesis of terminal alkynes possessing an allylic hydroxy group proceeded smoothly without the ethylene atmosphere generally necessary to promote the reaction. The synthesis of (+)-isofa... | 18,850,614 |
Interaction proteomics of the HMGA chromatin architectural factors. | The high mobility group A (HMGA) chromatin architectural transcription factors are a group of proteins involved in development and neoplastic transformation. They take part in an articulated interaction network, both with DNA and other nuclear proteins, organizing multimolecular complexes at chromatin level. Here, we r... | 18,850,631 |
Evaluation of carrier ampholyte-based capillary electrophoresis for separation of peptides and peptide mimetics. | Carrier ampholyte-based capillary electrophoresis (CABCE) has recently been introduced as an alternative to CE (CZE) in the classical buffers. In this study, isoelectric BGEs were obtained by fractionation of Servalyt pH 4-9 carrier ampholytes to cuts of typical width of 0.2 pH unit. CABCE feasibility was examined on a... | 18,850,645 |
Stacking enhanced determination of steroids by CE. | This study outlines a simple method for pH-mediated stacking of natural and synthetic steroids facilitated with carboxymethyl-beta-CD. Sample stacking (10 kV, 60 s) is accomplished with 23 mM carboxymethyl-beta-CD in 50 mM 3-[cyclohexylamino]-1-propanesulfonic acid buffered at pH 10. Following stacking, steroidal compo... | 18,850,649 |
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