title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Investigations into conformational transitions and solvation structure of a 7-piperidino-5,9-methanobenzo[8] annulene in water. | Solvation shell structure of a 7-piperidino-5,9-methanobenzo[8] annulene (PMA) in water has been investigated in ambient conditions using both molecular dynamics (MD) and Car-Parrinello molecular dynamics (CPMD) calculations. From the MD calculations, we find that this molecule exists in three major conformational stat... | 18,846,303 |
Comparison between a GnRH agonist and a GnRH antagonist protocol for the same patient undergoing IVF. | In order to compare GnRH agonist with antagonist protocol for the same patient during controlled ovarian stimulation cycles, the in vitro fertilization and embryo transfer (IVF-ET) outcome was retrospectively studied in 81 patients undergoing 105 agonist protocols and 88 antagonist protocols. The results showed that th... | 18,846,352 |
Support vector machine-based classification of Alzheimer's disease from whole-brain anatomical MRI. | We present and evaluate a new automated method based on support vector machine (SVM) classification of whole-brain anatomical magnetic resonance imaging to discriminate between patients with Alzheimer's disease (AD) and elderly control subjects. We studied 16 patients with AD [mean age +/- standard deviation (SD) = 74.... | 18,846,369 |
Hodgkin lymphoma in Tyrol-a population-based study. | We aimed to analyze the epidemiology, clinical characteristics, and outcome of patients with Hodgkin lymphoma (HL) diagnosed in Tyrol. All patients with newly diagnosed HL between 1993 and 2005 were included in this study. Among the 158 cases included, nodular lymphocytic predominant HL (nodular paragranuloma) was iden... | 18,846,373 |
Reactive oxygen species and inflammatory mediators enhance muscle spindles mechanosensitivity in rats. | We tested the hypothesis that reactive oxygen species (ROS) and inflammatory mediators affect transduction properties of muscle spindles. In rats, muscle spindles response to high-frequency vibration (HFV) was recorded before and after (1) injection of hydrogen peroxide (H2O2) in control rats and animals pre-treated wi... | 18,846,383 |
A historical analysis of severe head injury. | Severe head injury (SHI) is a significant health, social and economic concern rendering a worldwide health problem. This retrospective study was designed to describe the features and outcomes of patients with SHI treated in a single neurosurgical unit (Hospital "12 de Octubre", Madrid, Spain) over a period approaching ... | 18,846,394 |
Mechanisms of primary operative failure and results of remedial operation in patients with chronic pancreatitis. | Resection and drainage operations achieve long-term pain relief in approximately 85% of patients with chronic pancreatitis (CP). In patients who develop recurrent pain, a few data exist on the long-term results of remedial operations. Over an 18-year period (1988-2006), 316 patients with CP had primary resection or dra... | 18,846,404 |
Isolated polyethylene exchange versus acetabular revision for polyethylene wear. | Polyethylene wear and osteolysis are not uncommon in THA mid- and long-term. In asymptomatic patients the dilemma faced by the orthopaedic surgeon is whether to revise the cup and risk damage to the supporting columns and even pelvic discontinuity or to perform isolated polyethylene exchange and risk a high rate of pos... | 18,846,409 |
A perspective on Peter Mitchell and the chemiosmotic theory. | In 1991 Peter Mitchell wrote a last article that summarised his views on the origin, development and current status of his chemiosmotic ideas. I here review some of his views of that time on structures and mechanisms of several key bioenergetic components in relation to the subsequent advances that have been made. | 18,846,415 |
Predictors of sexual debut at age 16 or younger. | The present study examined the extent to which variables within the self system (i.e., symptoms of alcohol dependence and conduct disorder, gender, race, and metropolitan status) and the familial system (i.e., having an alcohol dependent biological parent or second-degree relative, religious background, educational bac... | 18,846,417 |
Mediators of neighborhood influences on externalizing behavior in preadolescent children. | This study tested a mediation model of neighborhood influences on children's externalizing behavior. In the proposed model, neighborhood disadvantage, ethnic heterogeneity, and low residential stability affect children's behavior indirectly through their impact on neighborhood social processes, which in turn influence ... | 18,846,420 |
Trichloroethylene cometabolic degradation by Rhodococcus sp. L4 induced with plant essential oils. | Cometabolic degradation of TCE by toluene-degrading bacteria has the potential for being a cost-effective bioremediation technology. However, the application of toluene may pose environmental problems. In this study, several plant essential oils and their components were examined as alternative inducer for TCE cometabo... | 18,846,429 |
A comparative study of noise pollution levels in some selected areas in Ilorin Metropolis, Nigeria. | The noise pollution is a major problem for the quality of life in urban areas. This study was conducted to compare the noise pollution levels at busy roads/road junctions, passengers loading parks, commercial, industrial and residential areas in Ilorin metropolis. A total number of 47-locations were selected within the... | 18,846,431 |
Hereditary haemochromatosis gene (HFE) H63D mutation shows an association with abnormal sperm motility. | The aim of this study was to screen infertile men for HFE H63D mutation in correlation with clinical characteristics of infertile men (sperm concentration, sperm motility, morphology, testicular volume, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and total Testosterone levels) and find out if the HFE H... | 18,846,434 |
Escape behaviour elicited by a visual stimulus. A comparison between lateralised and non-lateralised female topminnows. | Studies over the past 30 years suggest that functional lateralisation occurs in many animal species. Preferential eye use is ubiquitous among fish, and recently some advantages of being lateralised have been reported in the golden topminnow, Girardinus falcatus, using fish from lines selected for high or low degrees of... | 18,846,442 |
Mitral valve surgery--a Scandinavian perspective. | During the last three decades, the most prevalent surgical mitral valve disease in Scandinavia has changed from the sequelae of rheumatic fever to the mitral valve pathologies related to ischemic heart disease. Also, the total number of patients in need of a mitral valve procedure is increasing. For several of the pati... | 18,846,476 |
[Damage control orthopaedics in polytraumatised patients with lower leg injuries]. | In polytraumatised patients, fracture management depends on the overall injury severity. For decision making, patients are grouped in one of four categories (STABILE, BORDERLINE, INSTABLE and IN EXTREMIS). STABILE patients should and BORDERLINE patients may undergo primary definitive fracture stabilisation; in contrast... | 18,846,483 |
[Webers experiments regarding the stabilising effect of atmospheric pressure on the hip joint - a historical and experimental retrospect]. | The stabilising effect of atmospheric pressure on the hip joint was first described by the brothers Eduard and Wilhelm Weber in 1836. Later in 1837, they conducted an experiment in which they examined a weight-bearing cadaveric hip joint in an evacuable container and could repeatedly demonstrate dislocation of the femu... | 18,846,493 |
Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells. | Exposure of human HeLaS(3) cervix carcinoma cells to high doses of conventional cytostatic drugs, e.g. cisplatin (CP) strongly inhibits their proliferation. However, most cytostatic agents are genotoxic and may generate a secondary malignancy. Therefore, therapeutic strategy using alternative, not cytotoxic drugs would... | 18,846,503 |
Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. | The liver is a central organ involved in many aspects of physiology and disease. Signaling properties of hepatocytes, the main liver cell type, are of special interest in metabolic diseases and in regeneration. For this reason we investigated the phosphoproteome of the mouse liver cell line Hepa1-6 by stable isotope la... | 18,846,507 |
Proteomics and phosphoproteomics for the mapping of cellular signalling networks. | Proteomics is transitioning from inventory mapping to the mapping of functional cellular contexts. This has been enabled by progress in technologies as well as conceptual strategies. Here, we review recent advances in this area with focus on cellular signalling pathways. We discuss genetics-based methods such as yeast ... | 18,846,508 |
Autonomic innervation of the developing heart: origins and function. | Maintenance of homeostatic circulation in mammals and birds is reliant upon autonomic innervation of the heart. Neural branches of mixed cellular origin and function innervate the heart at the arterial and venous poles as it matures, eventually coupling autonomic output to the cardiac components, including the conducti... | 18,846,544 |
Shoes influence lower limb muscle activity and may predispose the wearer to lateral ankle ligament injury. | Lateral ankle ligaments are injured by hyperinversion of the foot. Foot position is controlled by the lower limb muscles. Awareness of foot position is impaired by wearing shoes. We aimed to determine the influence of wearing shoes upon muscle activity. Sixty-two healthy subjects underwent the same measurements, barefo... | 18,846,547 |
Chronic cough and tonsillar hypertrophy: a case series. | Two patients with intractable chronic cough were found to have tonsillar tissue impinging on their epiglottis. In both case, tonsillectomy was curative. The observations in these patients are consistent with a previous report indicating chronic cough from the uvula in contact with the epiglottis with cough cessation fo... | 18,846,560 |
Reproducibility of spirometry during cystic fibrosis pulmonary exacerbations. | To compare the within day variation of spirometry between hospital admission, discharge, and outpatient follow up among children with cystic fibrosis (CF) hospitalized for a pulmonary exacerbation. Within day variation of spirometry will be greater at hospital admission than at hospital discharge or outpatient follow u... | 18,846,562 |
Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan-induced diabetic rats. | Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture of... | 18,846,580 |
beta'-Hydroxy-alpha,beta-unsaturated ketones: A new pharmacophore for the design of anticancer drugs. Part 2. | Novel antiproliferative beta'-acyloxy-alpha,beta-unsaturated ketones were obtained by means of an iron(III)-catalyzed multicomponent domino process (ABB' 3CR). The most active derivatives displayed GI(50) values in the range of 0.5-3.9 muM against a panel of representative human solid tumor cell lines: A2780, SW1573, H... | 18,846,591 |
Interaction of NO2 with model NSR catalysts: metal-oxide interaction controls initial NOx storage mechanism. | Using scanning tunneling microscopy (STM), molecular-beam (MB) methods and time-resolved infrared reflection absorption spectroscopy (TR-IRAS), we investigate the mechanism of initial NO(x) uptake on a model nitrogen storage and reduction (NSR) catalyst. The model system is prepared by co-deposition of Pd metal particl... | 18,846,595 |
Efficient synthesis of dimethyl ether over HZSM-5 supported on medium-surface-area beta-SiC foam. | In this study, we aimed to produce a highly selective and stable catalyst for the production of dimethyl ether by methanol dehydration. The activities were compared of different active phases of the employed system, zeolite HZSM-5 or gamma-alumina, supported on silicon carbide as foam, and it was found that the support... | 18,846,596 |
[Abdominal compartment syndrome]. | Abdominal compartment syndrome is a potentially lethal condition caused by any event that produces intra-abdominal hypertension; the most common cause is blunt abdominal trauma Increasing intra-abdominal pressure causes progressive hypoperfusion and ischemia of the intestines and other peritoneal and retroperitoneal st... | 18,846,692 |
[Cystopericystectomy for the treatment of hepatic hydatid disease]. | Hepatic hydatid disease is current problem in Bulgaria as the country in endemic region. The treatment include PAIR, various type surgical procedures and medical therapy. Surgical treatment is conductive. Cystopericystectomy is one of radical procedures. The aim of this study is to present the experience of Department ... | 18,846,694 |
[Indirect prenatal molecular diagnostic of haemophilia A and B]. | Haemophilia A (HA) and B (HB) are the most common inherited bleeding diseases. HA and HB are X-linked recessive disorders caused by mutation in the factor VIII gene which maps to Xq28 and factor IX located at Xq27, respectively; resulting in absence or deficiency of these proteins. Several mutations have been reported ... | 18,846,770 |
Spot urine protein: creatinine ratio versus 24 hour urine protein at various levels of GFR patients referred to a tertiary care hospital of Pakistan. | To determine the correlation of "random single voided urine protein: creatinine ratio" to "twenty four hour urine protein" at different levels of glomerular filtration rate (GFR) in Pakistani population. A total of 107 patients were included in this cross section study. Patients were divided into five groups according ... | 18,846,792 |
Perinatal outcomes in pregnancy with asthma. | To examine the relationship between asthmatic pregnancies and selected maternal and neonatal outcomes in a representative cohort. A retrospective cohort study was conducted at the Aga Khan University Hospital during the year 2004. A random selection was made of 65 asthmatic and 63 non-asthmatic singleton births. The ne... | 18,846,809 |
A comparison of the efficacy of doramectin, closantel and levamisole in the treatment of the 'oriental eye fluke', Philophthalmus gralli, in commercially reared ostriches (Struthio camelus). | Commercially reared ostriches at Msengi farm situated in the Chinhoyi area of Mashonaland West province in Zimbabwe were found to be infected with the 'oriental eye fluke', Philopthalmus gralli, in 2001. This was the ist record of the fluke in Zimbabwe. Trials were conducted to identify a suitable drug for the treatmen... | 18,846,856 |
Castlemans disease in HIV infected patient from eastern India. | Castlemans disease is a rare lymphoproliferative disorder. We report a patient of Castlemans disease with advanced HIV infection who responded well to conventional HAART. This case is interesting because of the rarity of the disease in the eastern part of India and its good out come with antiretroviral therapy. | 18,846,911 |
Alkaptonuria and intramedullary calcification. | Alkaptonuria is a rare disorder of metabolism caused by deficiency of homogentisic acid oxidase enzyme and characterized by triad of homogentisic aciduria (dark urine), relentlessly progressive arthritis and ochronosis. We have documented a case with typical features of alkaptonuria along with intramedullary calcificat... | 18,846,913 |
Diagnostic algorithm and therapeutic options in chronic heart failure: updated review of clinical practice guidelines. | The development of diagnostic and therapeutic algorithms is becoming more and more popular in medicine. Their advantage is simplicity which enables wide use in everyday medical practice. The algorithms may have limitations mainly due to simplifications, which not always appear to be helpful in solving complex clinical ... | 18,846,984 |
[Etiology of Dupuytren's contracture]. | Dupuytren's contracture is a connective tissue disorder characterized by contractile palmar aponeurosis leading to shortening and progressive digital flexion deformity. Various investigators have proposed many theories and documented several findings regarding the aetiology of Dupuytren's contracture. However, none of ... | 18,847,012 |
[Modular short-stem prosthesis in total hip arthroplasty--preliminary report]. | Total hip arthroplasty has become one of the most succesful procedure in orthopaedic surgery. More and more active, young patients undergo primary hip replacement. Bone stock preservation is crucial when performing THR in this group of patients. The short stem design allows a methaphyseal intratrochanteric multipoint, ... | 18,847,014 |
[Effects of massage on delayed-onset muscle soreness]. | Delayed onset muscle soreness (DOMS) is the pain or discomfort often felt 12 to 24 hours after exercising and subsides generally within 4 to 6 days. Once thought to be caused by lactic acid buildup, a more recent theory is that it is caused by inflammatory process or tiny tears in the muscle fibers caused by eccentric ... | 18,847,018 |
Organized extracurricular activities of Canadian children and youth. | This article presents rates of participation in organized extracurricular activity by Canadian children and youth aged 6 to 17 years, and examines how these rates vary by sociodemographic and socio-economic characteristics. The data are from Cycle 4 of the National Longitudinal Survey of Children and Youth (2000/2001).... | 18,847,147 |
Radiological findings in sarcoidosis. | Sarcoidosis is a multisystemic disorder of unknown cause that primarily affects the lungs. The diagnosis is based on the clinical manifestations, radiological findings and histological examination. To review and illustrate the typical and atypical radiological findings of sarcoidosis in the chest. We analyzed the radio... | 18,847,152 |
Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation. | We show, both experimentally and by kinetic modeling, that enzymatic single-turnover (pre-steady-state) H-transfer reactions can be significantly complicated by kinetic isotope fractionation. This fractionation results in the formation of more protiated than deuterated product and is a unique problem for pre-steady-sta... | 18,847,184 |
Lewis acid stabilized methylidene and oxoscandium complexes. | The methylidene scandium complex (PNP)Sc(mu3-CH2)(mu2-CH3)2[Al(CH3)2]2 (PNP = N[2-P(CHMe2)2-4-methylphenyl]2-) can be prepared from the reaction of (PNP)Sc(CH3)2 and 2 equiv of Al(CH3)3. The Lewis acid stabilized methylidenes candium complex has been crystallographically characterized, and its bonding scheme analyzed b... | 18,847,190 |
Systematic synthesis, isolation, and photophysical properties of linear-shaped Re(I) oligomers and polymers with 2-20 units. | Systematic synthesis routes have been developed for the linear-shaped rhenium(I) oligomers and polymers bridged with bidentate phosphorus ligands, [Re(N--N)(CO)3-PP-{Re(N--N)(CO)2-PP-}(n)Re(N--N)(CO)3](PF6)(n+2) (N--N = diimine, PP = bidentate phosphine, n = 0-18). These were isolated by size exclusion chromatography (... | 18,847,194 |
Ferromagnetic ordering in bisthiaselenazolyl radicals: variations on a tetragonal theme. | A series of five isostructural bisthiaselenazolyl radicals 2 have been prepared and characterized by X-ray crystallography. The crystal structures, all belonging to the tetragonal space group P42(1)m, consist of slipped pi-stack arrays of undimerized radicals packed about 4 centers running along the z-direction, an arr... | 18,847,197 |
Amine-functionalized task-specific ionic liquids: a mechanistic explanation for the dramatic increase in viscosity upon complexation with CO2 from molecular simulation. | The capture of CO2 from fossil fuel combustion, particularly in coal-fired power plants, represents a critical component of efforts aimed at stabilizing greenhouse gas levels in the atmosphere. Alkanolamines have traditionally been used to this end; however, drawbacks such as volatility, degradation, and regeneration c... | 18,847,198 |
Acoustic particle filter with adjustable effective pore size for automated sample preparation. | This article presents analysis and optimization of a microfluidic particle filter that uses acoustic radiation forces to remove particles larger than a selected size by adjusting the driving conditions of the piezoelectric transducer (PZT). Operationally, the acoustic filter concentrates microparticles to the center of... | 18,847,218 |
A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. | The common reactions of dioxygen, superoxide, and hydroperoxides with thiolates are thought to proceed via persulfenate intermediates, yet these have never been visualized. Here we report a 1.4 A resolution crystal structure of the Fe(2+)-dependent enzyme cysteine dioxygenase (CDO) containing this putative intermediate... | 18,847,220 |
Quantitative evaluation of cross correlation between two finite-length time series with applications to single-molecule FRET. | The statistical properties of the cross correlation between two time series has been studied. An analytical expression for the cross correlation function's variance has been derived. On the basis of these results, a statistically robust method has been proposed to detect the existence and determine the direction of cro... | 18,847,232 |
On the structures of the diterpenes licamichauxiioic acids A and B. | The structures of the diterpenes licamichauxiioic acids A and B, isolated from Licania michauxii, which had been reported as 15-oxo-ent-kaur-9(11),16-dien-19-oic acid (1) and 15-oxo-ent-kaur-13,16-dien-19-oic acid (3), respectively, are not correct. Starting from grandiflorenic acid (6) we had prepared a compound with ... | 18,847,245 |
Trans-selective asymmetric aziridination of diazoacetamides and N-Boc imines catalyzed by axially chiral dicarboxylic acid. | Axially chiral dicarboxylic acid (R)-1d catalyzed reaction of diazoacetamides and N-Boc imines provided a novel organocatalytic means for the formation of enantiomerically enriched N-Boc protected trans aziridines. | 18,847,267 |
Tyrosine derivatives isolated from Streptomyces sp. IFM 10937 in a screening program for TRAIL-resistance-overcoming activity. | Exploration of actinomycetes for isolation of natural products for abrogating TRAIL resistance led to the isolation of two new tyrosine derivatives (1 and 2) along with novobiocin (3). The structures of 1 and 2 were determined by spectroscopic methods, while the absolute configuration was determined by analyzing CD spe... | 18,847,278 |
Measuring an antibody affinity distribution molecule by molecule. | Single molecule fluorescence microscopy was used to observe the binding and unbinding of hapten decorated quantum dots to individual surface immobilized antibodies. The fluorescence time history from an individual antibody site can be used to calculate its binding affinity. While quantum dot blinking occurs during thes... | 18,847,284 |
Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration. | Plasmid DNA vaccination combined with electroporation (EP) provides a promising approach for the prevention of infectious diseases and for cancer immunotherapy. This technology has been described as being effective in activating humoral and cellular immune response in the host as well as in enhancing expression of the ... | 18,847,301 |
Natural Treg in autoimmune diabetes: all present and correct? | The critical role for regulatory T cells (Treg) in suppressing autoimmune pathology is now well recognised. However, the extent to which defects in regulation can be blamed for the onset of diseases like type 1 diabetes is not clear. To collate the available data from mouse models and from studies of type 1 diabetes pa... | 18,847,305 |
The evolution of biomarkers in rheumatoid arthritis: from clinical research to clinical care. | Treatment efficacy in rheumatoid arthritis (RA) has been measured by clinical response, gross radiological results and some biochemical markers. With the new biologic treatments, markers for disease development, progress, severity and therapy response have evolved. This review focuses on a selection of current markers ... | 18,847,311 |
Sialome individuality between Aedes aegypti colonies. | Aedes aegypti is responsible for the transmission of arboviruses. The Yellow Fever, Dengue and Chikungunya viruses are transmitted to the vertebrate host by injection of infected saliva during the blood meal of its vectors. Saliva contains different components with various biochemical activities; anti-hemostatic, angio... | 18,847,318 |
Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats. | Recent clinical trials with bisphosphonates and PTH have not supported the hypothesis that combination treatments with antiresorptive and anabolic agents would lead to synergistic activity. We hypothesized that combination treatment with a selective androgen receptor modulator (SARM), LGD-3303, and a bisphosphonate wou... | 18,847,323 |
Nanofabricated collagen-inspired synthetic elastomers for primary rat hepatocyte culture. | Synthetic substrates that mimic the properties of extracellular matrix proteins hold significant promise for use in systems designed for tissue engineering applications. In this report, we designed a synthetic polymeric substrate that is intended to mimic chemical, mechanical, and topological characteristics of collage... | 18,847,357 |
Introduction of a novel prototype bioartificial liver support system utilizing small human hepatocytes in rotary culture. | The aim of this study was to establish a stand-alone, perfused, rotary cell culture system using small human hepatocytes (SH) for bioartificial liver (BAL) support. SH were grown on cytodex 3 microcarriers (beads) to a maximum density of 1.2 +/- 0.3 x 10(7) cells per mL within 12 days. Size of aggregates formed by up t... | 18,847,359 |
Oxidative stress, free radicals and bone remodeling. | Reactive oxygen species (ROS) are widely considered to be a causal factor in aging and in a number of pathological conditions, such as atherosclerosis, carcinogenesis and infarction. Their role in bone metabolism is dual, considering their effects under physiological or pathological conditions. Under physiological cond... | 18,847,368 |
Antimicrobial susceptibility of foodborne pathogens in organic or natural production systems: an overview. | Organic and natural food production systems are increasing in popularity, at least partially because consumers perceive that these niche markets provide healthier and safer food products. One major difference between these niche markets and conventional production systems is the use of antimicrobials. Because antimicro... | 18,847,380 |
Expressions of HIV-related stigma among rural-to-urban migrants in China. | In China, HIV-related stigma is considered as a formidable barrier in the combat against the HIV epidemic. There have been few qualitative investigations on HIV-related stigma in China, especially among a vulnerable population of rural-to-urban migrants. Based on 90 in-depth interviews conducted in 2002-2003 with rural... | 18,847,389 |
Resistance in bacteria of the food chain: epidemiology and control strategies. | Bacteria have evolved multiple mechanisms for the efficient evolution and spread of antimicrobial resistance. Modern food production facilitates the emergence and spread of resistance through the intensive use of antimicrobial agents and international trade of both animals and food products. The main route of transmiss... | 18,847,409 |
Aberrant promoter CpG island hypermethylation of the adenomatosis polyposis coli gene can serve as a good prognostic factor by affecting lymph node metastasis in squamous cell carcinoma of the esophagus. | There has been no clear evidence demonstrating whether DNA hypermethylation can affect the prognosis of esophageal cancer. We collected tissue from 50 cases of squamous cell carcinoma of the esophagus and tested them for DNA hypermethylation using methylation-specific polymerase chain reaction. CpG island hypermethylat... | 18,847,451 |
Can immune-enhancing nutrients reduce postoperative complications in patients undergoing esophageal surgery? | Postoperative infection of esophageal neoplasm surgery is the major cause of prolonged postoperative hospitalization, as well as morbidity. The clinical benefits of administering immune-enhancing nutrients (IEN) to critically ill patients and those undergoing elective surgery were clarified. However, the benefits of pr... | 18,847,452 |
Genomics research: world survey of public funding. | Over the past two decades, genomics has evolved as a scientific research discipline. Genomics research was fueled initially by government and nonprofit funding sources, later augmented by private research and development (R&D) funding. Citizens and taxpayers of many countries have funded much of the research, and h... | 18,847,466 |
PCR and real-time PCR primers developed for detection and identification of Bifidobacterium thermophilum in faeces. | Culture-independent methods based on the 16S ribosomal RNA molecule are nowadays widely used for assessment of the composition of the intestinal microbiota, in relation to host health or probiotic efficacy. Because Bifidobacterium thermophilum was only recently isolated from human faeces until now, no specific real-tim... | 18,847,469 |
Molecular and phylogenetic analysis of HIV-1 variants circulating in Italy. | The continuous identification of HIV-1 non-B subtypes and recombinant forms in Italy indicates the need of constant molecular epidemiology survey of genetic forms circulating and transmitted in the resident population. The distribution of HIV-1 subtypes has been evaluated in 25 seropositive individuals residing in Ital... | 18,847,472 |
Functional identification of NR2 subunits contributing to NMDA receptors on substance P receptor-expressing dorsal horn neurons. | NMDA receptors are important elements in pain signaling in the spinal cord dorsal horn. They are heterotetramers typically composed of two NR1 and two of four NR2 subunits: NR2A-2D. Mice lacking specific NR2 subunits show deficits in pain transmission yet subunit location in the spinal cord remains unclear. We have com... | 18,847,474 |
Cadaveric and three-dimensional computed tomography study of the morphology of the scapula with reference to reversed shoulder prosthesis. | The purpose of this study is to analyze the morphology of the scapula with reference to the glenoid component implantation in reversed shoulder prosthesis, in order to improve primary fixation of the component. Seventy-three 3-dimensional computed tomography of the scapula and 108 scapular dry specimens were analyzed t... | 18,847,487 |
Session 2: Personalised nutrition. Metabolomic applications in nutritional research. | Metabolomics aims to profile all small molecules that are present in biological samples such as biofluids, tissue extracts and culture media. Combining the data obtained with multivariate data analysis tools allows the exploration of changes induced by a biological treatment or changes resulting from phenotype. Recentl... | 18,847,517 |
Etiological factors and mortality of acute intestinal obstruction: a review of 705 cases. | To figure out the etiological factors and overall mortality of the patients with acute intestinal obstruction, and to explore the rational period of conservative therapy before operation. Medical records of all the patients with acute intestinal obstruction admitted to West China Hospital from 1995 to 2002 were retrosp... | 18,847,534 |
[Illicit drugs, medications and traffic accidents]. | The European Union (EU) has 25 member-states and 455 million inhabitants. Statistics on traffic accidents in the EU show that more than 45,000 people are killed annually, including 5200 in France. At the same time, nearly two million persons in the EU require medical treatment for traffic-accident-related injuries, inc... | 18,847,565 |
[Similarity of biotechnology-derived drugs: regulatory framework and specificity]. | Directive 2004/27/EC, issued by the European commission specifies the conditions by which marketing approval can be awarded for a biosimilar drug, whose structure is the closest possible to that of an already marketed biotechnology-drug. This specific regulation differs in more than one point from that applied to class... | 18,847,566 |
[Cannabis and safety of work. Evolution of its detection within the controls of narcotics since 2004 to the SNCF]. | Fifteen to 20 % of fatal work-related accidents would be connected to the use of alcohol, psychotrops or narcotics. Many constraints restrain the systematic detection of addictive behaviour at work. The restraints can be financial, ethical, technical or laid down in the regulations. The occupational physician remains t... | 18,847,573 |
A prospective evaluation of the effect of sample collection site on intraoperative parathormone monitoring during parathyroidectomy. | Sample collection site may affect the dynamics of intraoperative parathyroid hormone monitoring (IPM) and influence surgical decisions. We prospectively studied 45 patients undergoing parathyroidectomy for primary hyperparathyroidism. The IPM cure criterion was a decrease in peripheral vein (PV) parathyroid hormone (PT... | 18,847,632 |
Human error, not communication and systems, underlies surgical complications. | This study prospectively assesses the underlying errors contributing to surgical complications over a 12-month period in a complex academic department of surgery using a validated scoring template. Studies in "high reliability organizations" suggest that systems failures are responsible for errors. Reports from the avi... | 18,847,639 |
Reoperative parathyroidectomy: an algorithm for imaging and monitoring of intraoperative parathyroid hormone levels that results in a successful focused approach. | Advances in preoperative imaging and use of intraoperative parathyroid hormone (IOPTH) levels are changing the approach to reoperative parathyroidectomy (ReopPTX). We sought to develop a protocol for imaging and IOPTH monitoring that allows for a focused, successful operative approach. We reviewed our prospective datab... | 18,847,646 |
Algorithm for head computed tomography imaging in patients with mandible fractures. | Trauma to the mandible can potentially increase our predictive accuracy for intracranial injuries (ICIs) because of the mandible's strength, anatomic proximity, and direct connection to the skull base. Our goals were to: 1) investigate the association of mandible fractures with traumatic brain injury (TBI) and intracra... | 18,848,107 |
Secondarily stabilized dental implants: an alternative to sinus grafting--early clinical results of 63 consecutively placed implants. | A standard dental implant modified with an apical cross-screw was studied clinically in the posterior maxilla in a trial of 63 sinus-penetrating implants. Twenty-five patients who had cross-screw implants placed in the atrophic posterior maxilla were followed for up to 3 years. Of 63 implants placed, 5 implants failed ... | 18,848,114 |
Long-term impact of drug-eluting stents versus bare-metal stents on all-cause mortality. | Our purpose was to examine the incidence of all-cause mortality among drug-eluting stents (DES) and bare-metal stents (BMS) while adjusting for many confounding factors generally not considered in prior studies. DES use in the U.S. declined by up to 50% in recent years, primarily due to concerns about late stent thromb... | 18,848,135 |
Venous thromboembolism in Spain. Comparison between an administrative database and the RIETE registry. | The aim of this study was to validate the baseline characteristics of the RIETE cohort against the much larger national Spanish population-based database. The RIETE is an ongoing registry of consecutive patients with symptomatic, objectively confirmed, acute venous thromboembolism (VTE). We compared some baseline chara... | 18,848,178 |
Perioperative glucocorticosteroid supplementation is not supported by evidence. | Ever since the first descriptions of adrenal insufficiency following exogenous supplementation physicians dread to abolish perioperative glucocorticosteroid supplementation. Now, 55 years after the first publications we can challenge those first reports. However, these cases have resulted in the supplementation of supr... | 18,848,181 |
Diagnosis and initial management of cerebellar infarction. | Cerebellar infarction is an important cause of stroke that often presents with common and non-specific symptoms such as dizziness, nausea and vomiting, unsteady gait, and headache. Accurate diagnosis frequently relies on careful attention to patients' coordination, gait, and eye movements--components of the neurologica... | 18,848,314 |
Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. | The urinary proteome is a potential easily accessible source of biomarkers for inflammatory bladder diseases, including interstitial cystitis. In the present study, we subjected rat urine to multiplex cytokine analysis in an attempt to identify an inflammatory signature of the temporal course of cyclophosphamide (CYP)-... | 18,848,347 |
Outcome of patients with bladder cancer with pN+ disease after preoperative chemotherapy and radical cystectomy. | Persistent nodal disease in the surgical specimen (pN+) after preoperative chemotherapy for urothelial carcinoma is associated with a poor prognosis. To improve our understanding regarding the outcomes of such patients, we performed a retrospective review of our experience. From 1993 to 2003, 857 patients underwent rad... | 18,848,348 |
Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program. | Among asthmatic subjects, bronchodilator response (BDR) to inhaled beta(2)-adrenergic agonists is variable, and the significance of a consistent response over time is unknown. We assessed baseline clinical variables and determined the clinical outcomes associated with a consistently positive BDR over 4 years in childre... | 18,848,350 |
Nitrogen limited biobarriers remove atrazine from contaminated water: laboratory studies. | Atrazine is one of the most frequently used herbicides. This usage coupled with its mobility and recalcitrant nature in deeper soils and aquifers makes it a frequently encountered groundwater contaminant. We formed biobarriers in sand filled columns by coating the sand with soybean oil; after which, we inoculated the b... | 18,848,368 |
In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: synthesis, spectroscopic study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agents. | Reactions of thiosemicarbazones of 2-formyl and 2-acetyl pyridine and containing an azepane ring (hexamethyleneiminyl ring) incorporated at N(4)-position, HL(1) (1) and HL(2) (2) with platinum(II) afforded the complexes, [Pt(L(1))Cl] (3) and [Pt(L(2))Cl] (4). Characterization of the compounds was accomplished by means ... | 18,848,372 |
Assessing joint toxicity of chemicals in Enchytraeus albidus (Enchytraeidae) and Porcellionides pruinosus (Isopoda) using avoidance behaviour as an endpoint. | Contamination problems are often characterized by complex mixtures of chemicals. There are two conceptual models usually used to evaluate patterns of mixture toxicity: Concentration Addition (CA) and Independent Action (IA). Deviations from these models as synergism, antagonism and dose dependency also occur. In the pr... | 18,848,376 |
Tracking and determinants of kidney size from fetal life until the age of 2 years: the Generation R Study. | An adverse fetal environment may lead to smaller kidneys and subsequently kidney disease and hypertension in adulthood. The aims of this study are to examine whether kidney size tracks from fetal life to childhood and whether maternal and fetal characteristics are associated with kidney size at the age of 2 years. Pros... | 18,848,377 |
Plasma exchange for disseminated cryptococcosis. | Acute renal failure is frequent in HIV-infected patients and may be related to HIV-associated nephropathy, drugs, or opportunistic infections. We report a peculiar case of disseminated cryptococcosis complicated by acute renal failure associated with obstruction of intrarenal capillaries by Cryptococus neoformans dead ... | 18,848,378 |
Approach for valuating the significance of laboratory simulation. | The aim of this investigation was to compare the clinical survival rate of all-ceramic FPDs with failures during in vitro simulation. 40 anterior FPDs were manufactured from lithiumdisilicate ceramic and alumina-oxide ceramic. The FPDs were adhesively bonded to human teeth and artificially aged to investigate the survi... | 18,848,380 |
The pressure angle of the median nerve as a new magnetic resonance imaging parameter for the evaluation of carpal tunnel. | The purpose of this study was to compare the MRI findings of the wrists of patients with carpal tunnel syndrome (CTS) and controls. We present a new MRI parameter, the pressure angle of the median nerve, in CTS patients. The study included 55 wrists, 36 of which were diagnosed with CTS and 19 healthy controls. All subj... | 18,848,388 |
Influence of pyrometallurgical copper production on the environment. | In this paper the influence of pyrometallurgical treatment of copper sulphide minerals and pyrite on the environment from the aspect of ambient air pollutions is considered. Results of emission of SO(2) and particulate matter from the location with the most pollution are presented. According to the results it could be ... | 18,848,391 |
Insulin therapy in preterm newborns. | The perinatal period is known to be a critical period for pancreatic development, and the impact of prematurity on the development of insulin secretion and sensitivity is poorly defined. Premature infants are at risk of hyperglycaemia which is a marker of relative insulin deficiency which impacts on anabolism both dire... | 18,848,411 |
Six-year change in youth physical activity and effect on fasting insulin and HOMA-IR. | There is a shortage of longitudinal data analyzing associations between physical activity and indicators of insulin resistance among children and adolescents after accounting for adiposity change. To guide future prevention efforts, data were used from the Danish arm of the European Youth Heart Study to examine these i... | 18,848,414 |
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