title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression. | A subset of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1(SM)) is involved in the cytoadherence of P. falciparum-infected red blood cells (iRBC) contributing to the pathogenesis of severe disease among young children in malaria endemic areas. The PfEMP1(SM) are encoded by group A var genes that are c... | 18,844,973 |
Pre-operative diagnosis of an unusual complication of abdominal aortic aneurysm on multidetector computed tomography: a case report. | Spontaneous fistulation of an abdominal aortic aneurysm (AAA) into the inferior vena cava (IVC) is an unusual and infrequently encountered complication in clinical practice. In the majority of cases, it is a diagnosis made on the operating table, during surgical repair of AAA. We report a patient with an aortocaval fi... | 18,845,001 |
Potential of an alternative prey to disrupt predation of the generalist predator, Orius insidiosus, on the pest aphid, Aphis glycines, via short-term indirect interactions. | Generalist insect predators can significantly impact the dynamics of pest populations; and, using alternative prey, they can rapidly establish in disturbed agroecosystems. However, indirect interactions between prey can occur, leading to either increased or decreased predation on focal prey. The present paper demonstra... | 18,845,007 |
Lamotrigine-associated rash: to rechallenge or not to rechallenge? | The major burden of illness in bipolar disorder (BD) is in the depressive pole. Lamotrigine has been shown to be useful in the long-term prophylaxis of depressive episodes in BD. Current guidelines recommend discontinuing lamotrigine in patients who develop rash. Our objective in this paper is to review literature to i... | 18,845,017 |
Sex ratio at birth and family composition in sub-saharan Africa: inter-couple variations. | In this study, sex ratios at birth (male/female births) were found to vary according to family composition. Using Demographic and Health Survey (DHS) maternity histories from sub-Saharan Africa, the study shows that the sex ratio at birth increases with the number of previous male births and decreases with the number o... | 18,845,027 |
Our patients do not need endocarditis prophylaxis for genitourinary tract procedures: insights from the 2007 American Heart Association guidelines. | The 2007 American Heart Association guidelines for the prevention of infective endocarditis have dramatically reduced both the types of eligible procedures and the types of eligible cardiac lesions that require prophylaxis. Antibiotic prophylaxis to prevent infective endocarditis is not indicated for any patient underg... | 18,845,049 |
Functional overloading facilitates the regeneration of injured soleus muscles in mice. | The effect of functional overloading on the regenerating process of injured skeletal muscle was investigated in 10-week-old male mice (C57BL/6J). Functional overloading on soleus of both hindlimbs was performed by cutting the distal tendons of plantaris and gastrocnemius muscles for 2 weeks before cardiotoxin (CTX) inj... | 18,845,057 |
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. | Seborrheic keratosis (SK) is one of the more common benign epidermal neoplasms seen in adult and middle-aged patients. As little is written in the literature about the variants of SK, this article aims to categorize and discuss the different subtypes and their important associations. An in-depth literature search using... | 18,845,088 |
Cutaneous granulomas with predominantly CD8(+) lymphocytic infiltrate in a child with severe combined immunodeficiency. | Combined immunodeficiency disorders comprise a heterogeneous group of diseases characterized by both humoral and cell-mediated immunodeficiency. Cutaneous granulomas manifestations in children with combined immunodeficiency are rare. We report the case of a 6-year-old boy who presented with disseminated cutaneous granu... | 18,845,095 |
Occupational allergic contact dermatitis from epoxy resin in a golf club repairman. | A golfer presented with facial and hand eczema. He had exacerbations of his hand eczema prior to golf tournaments. Being an authorized golf club repairman, he had been working with a two-part glue containing an epoxy resin (ER) based on diglycidyl ether of bisphenol A (DGEBA) and the hardener diethylenetriamine (DETA) ... | 18,845,108 |
Preliminary investigation to determine the cytotoxicity of various cryoprotectants on southern African abalone (Haliotis midae) embryos. | Cryopreservation could provide stock quantities of embryos for transgenic research. This study aimed to determine the least toxic cryoprotective agent for Haliotis midae embryos. They were exposed for 30min to concentrations varying from 5% to 20% of the following cryopreservatives: methanol (MET), polyethylene glycol ... | 18,845,135 |
DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variation. | Most mouse embryos developing in the absence of the oocyte-derived DNA methyltransferase 1o (DNMT1o-deficient embryos) have significant delays in development and a wide range of anatomical abnormalities. To understand the timing and molecular basis of such variation, we studied pre- and post-implantation DNA methylatio... | 18,845,137 |
Intracellular trafficking of Notch receptors and ligands. | The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway. Notch signaling requires end... | 18,845,146 |
Structure of the cyclomodulin Cif from pathogenic Escherichia coli. | Bacterial pathogens have evolved a sophisticated arsenal of virulence factors to modulate host cell biology. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) use a type III protein secretion system (T3SS) to inject microbial proteins into host cells. The T3SS effector cycle inhibiting factor (Cif... | 18,845,161 |
Modeling distributions of flying insects: effective attraction radius of pheromone in two and three dimensions. | The effective attraction radius (EAR) of an attractive pheromone-baited trap was defined as the radius of a passive "sticky" sphere that would intercept the same number of flying insects as the attractant. The EAR for a particular attractant and insect species in nature is easily determined by a catch ratio on attracti... | 18,845,163 |
Thermodynamics and folding pathway of tetraloop receptor-mediated RNA helical packing. | Little is known about the thermodynamic forces that drive the folding pathways of higher-order RNA structure. In this study, we employ calorimetric [isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC)] and spectroscopic (NMR and UV) methods to characterize the thermodynamics of the GAAA t... | 18,845,162 |
Fragrance material review on 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate. | A toxicologic and dermatologic review of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate when used as a fragrance ingredient is presented. | 18,845,203 |
Fragrance material review on amylcyclohexyl acetate. | A toxicologic and dermatologic review of amylcyclohexyl acetate when used as a fragrance ingredient is presented. | 18,845,222 |
Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. | The present study was conducted to investigate the role of arjunolic acid (AA) against sodium fluoride (NaF)-induced cytotoxicity and necrotic cell death in murine hepatocytes. Dose-dependent studies suggest that incubation of hepatocytes with NaF (100mM) for 1h significantly decreased the cell viability as well as int... | 18,845,235 |
The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. | Sepsis is characterised by a systemic dysregulated inflammatory response and oxidative stress, often leading to organ failure and death. Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. MitoQ is an antioxidant selectively targeted to... | 18,845,241 |
Acetylcholine activity in selective striatal regions supports behavioral flexibility. | Daily living often requires individuals to flexibly respond to new circumstances. There is considerable evidence that the striatum is part of a larger neural network that supports flexible adaptations. Cholinergic interneurons are situated to strongly influence striatal output patterns which may enable flexible adaptat... | 18,845,266 |
Habituation in songbirds. | Songbirds respond to initial playback of a recorded conspecific song in numerous ways, from changes in gene expression in the brain to changes in overt physical activity. When the same song is presented repeatedly, responses have been observed to habituate at multiple levels: molecular, cellular and organismal. Core cr... | 18,845,267 |
Abdominal hysterectomy with or without angle stitch: correlation with subsequent vaginal vault prolapse. | The objective of the study was to assess whether cardinal-uterosacral ligament lateral vaginal cuff angle stitches at the time of total hysterectomy may assist in preventing subsequent apical vault prolapse. Total hysterectomies without cuff angle stitches were performed in 7 unembalmed cadavers. Successive hanging wei... | 18,845,281 |
Continuing improvement of chronic pelvic pain in women after short-term Mensendieck somatocognitive therapy: results of a 1-year follow-up study. | Chronic pelvic pain is a common source of disability among women in the western world. Here we report that 3 months of Mensendieck somatocognitive intervention in chronic pelvic pain patients was followed by continued improvements of outcomes at 1-year follow-up in a randomized, controlled study design. Forty women wit... | 18,845,283 |
Prospective study of cardiorespiratory fitness and depressive symptoms in women and men. | Most studies of the relationship between cardiorespiratory fitness (CRF) and depression have been limited to cross-sectional designs. The objective of this study was to follow individuals over time to examine whether those with higher levels of CRF have lower risk of developing depressive symptoms. Participants were 11... | 18,845,305 |
Mechanistic studies on PseB of pseudaminic acid biosynthesis: a UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase. | UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase (PseB) is a unique sugar nucleotide dehydratase that inverts the C-5'' stereocentre during conversion of UDP-N-acetylglucosamine to UDP-2-acetamido-2,6-dideoxy-beta-l-arabino-hexos-4-ulose. PseB catalyzes the first step in the biosynthesis of pseudaminic acid, which i... | 18,845,311 |
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. | The transforming growth factor-beta (TGF-beta) induces apoptosis in hepatocytes through an oxidative stress process. Here, we have analyzed the role of different NADPH oxidase isoforms in the intracellular signalling induced by TGF-beta in hepatocytes, to later explore whether this mechanism is altered in liver tumor c... | 18,845,355 |
Type 3 metallothioneins respond to water deficit in leaf and in the cambial zone of white poplar (Populus alba). | The involvement of metallothioneins (MTs) in response to plant water stress and recovery was assessed by analyzing gene expression in leaves and in the cambial zone of white poplar. One-year-old plants were submitted to two different watering regimes: irrigation was withheld for 9d and then resumed until day 17, or soi... | 18,845,361 |
The fast track back to registered nurses employment. | The registered nurse (RN) workforce continues to decline. One method to attract experienced RNs into the workforce is through RN refresher courses. To determine if our RN refresher program is successful in returning RNs to the workforce, we sought to measure the: characteristics of RNs who participate in our program; r... | 18,845,364 |
Risk of hemodialysis graft thrombosis: analysis of monthly flow surveillance. | During clinical application of flow surveillance of hemodialysis grafts, the risk of thrombosis is assessed month after month, rather than after one or several measurements, as has been done in published studies. Adequate assessment of risk should consider the many measurements obtained over time. Prospective cohort di... | 18,845,369 |
Motor and language deficits before and after surgical resection of mesial frontal tumour. | The goal of the present study was to better characterize pre- and immediately post-surgical motor and language deficits resulting from the surgery of tumours located in the medial part of the frontal lobe. Seven patients treated by surgical resection of low-grade gliomas affecting the medial part of the frontal lobe we... | 18,845,388 |
[Emergence of vancomycin-dependent enterococci following glycopeptide therapy: case report and review]. | Outbreaks of vancomycin-resistant enterococci have been increasingly reported in France over the last three years. We report here, the emergence of a vancomycin-dependent enterococci isolate following glycopeptide therapy. An Enterococcus faecium isolate that required vancomycin for growth was cultured from the stools ... | 18,845,404 |
Psychotropic medication use for challenging behaviors in persons with intellectual disabilities: an overview. | Challenging behaviors in persons with intellectual disabilities are primary target for treatment in mental health clinics and institutions. Furthermore, an increasing number of people are receiving psychotropic medications for the management of their challenging behaviors. Many people are often treated with high doses ... | 18,845,418 |
Interactions of Bacillus spp. and plants--with special reference to induced systemic resistance (ISR). | Biological control of soil-borne pathogens comprises the decrease of inoculum or of the disease producing activity of a pathogen through one or more mechanisms. Interest in biological control of soil-borne plant pathogens has increased considerably in the last few decades, because it may provide control of diseases tha... | 18,845,426 |
Comparative analysis of the street generation of inorganic urban solid waste (IUSW) in two neighborhoods of Mexico City. | Inorganic urban solid waste (IUSW) is a serious problem in developing countries, and IUSW in the street that does not have adequate final disposal is responsible for serious environmental effects. The aim of this work was to determine the dynamics of the generation of IUSW in the streets of two neighborhoods of differe... | 18,845,430 |
Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. | The cytotoxic macrolide kendomycin was identified as a ligand of Bcl-xl, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xl binding. | 18,845,435 |
Piperidine dispiro-1,2,4-trioxane analogues. | Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to the amine 1,2,4-trioxane hydrochloride salt 3 which was subsequently u... | 18,845,438 |
Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant. | The 3C-like (3CL) protease of the severe acute respiratory syndrome (SARS) coronavirus is a key enzyme for the virus maturation. We found for the first time that the mature SARS 3CL protease is subject to degradation at 188Arg/189Gln. Replacing Arg with Ile at position 188 rendered the protease resistant to proteolysis... | 18,845,442 |
A versatile microfluidic chip for millisecond time-scale kinetic studies by electrospray mass spectrometry. | An electrospray coupled microfluidic reactor for the measurement of millisecond time-scale, solution phase kinetics is introduced. The device incorporates a simple two-channel design that is etched into polymethyl methacrylate (PMMA) by laser ablation. The outlet of the device is laser cut to a sharp tip, facilitating ... | 18,845,447 |
Herpesviruses and the transplanted lung: looking at the air side. | Herpesviruses may cause substantial complications after lung transplantation. Especially their interaction with lung tissue cells may result in adverse effects for the transplant patients, and may lead to severe end organ disease or to chronic transplant rejection and to development of bronchiolitis obliterans (BOS). H... | 18,845,472 |
Toll-like receptors and cytokines in immune responses to persistent mycobacterial and Salmonella infections. | Bacterial persistence is of major concern worldwide in the control of a number of bacterial infections. The carriers who are asymptomatic act as reservoirs of the bacteria. Knowledge of the host response, of the persistence process, and of the potential of biological mediators as diagnostic markers is essential towards... | 18,845,475 |
Listening to the voices of patients with cancer, their advocates and their nurses: A hermeneutic-phenomenological study of quality nursing care. | This article presents the findings from a hermeneutic-phenomenological study looking at the meanings of "quality nursing care" through the experiences of patients with cancer, their advocates and their nurses. Twenty-five patients were interviewed from which fifteen also participated in two focus groups. Six patients' ... | 18,845,478 |
Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells? | We have utilized soluble HIV Gag-specific T-cell receptor (TCR) D3 with low affinity and TCR-like antibody 25-D1.16 recognizing its natural peptide-MHC (pMHC) ligand with high affinity to determine how affinity and off-rate of the receptor-pMHC interactions affect the sensitivity of pMHC detection on the cell surface. ... | 18,845,488 |
Prenatal inflammation and lung development. | Prenatal exposure of very low birth weight infants to chronic indolent chorioamnionitis with organisms such as mycoplasma and ureaplasma is frequent. Chorioamnionitis is inconsistently associated with changed risks of respiratory distress syndrome (RDS) or bronchopulmonary dysplasia (BPD), probably because the diagnosi... | 18,845,493 |
[Tumor vasculature as a therapeutic target in non-small cell lung cancer]. | Despite developments in conventional (chemo)radiotherapy and surgery, survival of non-small cell lung cancer (NSCLC) patients remains poor. Treatments with targeted molecular drugs offer novel therapeutic strategies. Bevacizumab, a recombinant anti-vascular endothelial growth factor (VEGF) antibody, is the antiangiogen... | 18,845,495 |
[Fifty-year-old history of cobalt radiotherapy in Hungary]. | The first patient in Hungary was treated by cobalt therapy fifty years ago at the National Institute of Oncology with a Gravicert type equipment. On the occasion of this anniversary, the 50-year history of the Hungarian cobalt therapy is reviewed, and its present role is discussed. The first cobalt unit (Gravicert) was... | 18,845,501 |
[The elderly driver's perception of risk: do older drivers still express comparative optimism? ]. | People frequently express comparative optimism ; that is, they believe they are less likely than average to experience negative events. The aim of the present study is, first, to observe whether people of more than 65 years are still optimists when they evaluate driving-related risks; and second, to test the assumption... | 18,845,511 |
A questionnaire survey of physicians' perspectives regarding the assessment of chemotherapy-induced peripheral neuropathy in patients with breast cancer. | Since there is now growing interest in the incorporation of patient-reported outcome measures in cancer clinical trials, a patient-based questionnaire, the Patient Neurotoxicity Questionnaire (PNQ) was developed to quantify the symptoms and severity of chemotherapy-induced peripheral neuropathy (CIPN). The aim of this ... | 18,845,520 |
Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase. | Eg5 is a motor protein of the kinesin family that is critical for spindle assembly during mitosis and has recently been implicated in tumorigenesis. It is largely unknown how Eg5 expression is regulated in cells. In this study, we present the first evidence that the cellular Eg5 level is down-regulated by Parkin, an E3... | 18,845,538 |
Evidence for variable selective pressures at a large secondary structure of the human mitochondrial DNA control region. | A combined effect of functional constraints and random mutational events is responsible for the sequence evolution of the human mitochondrial DNA (mtDNA) control region. Most studies targeting this noncoding segment usually focus on its primary sequence information disregarding other informative levels such as secondar... | 18,845,547 |
Effects of continuous positive airway pressure therapy on left ventricular function assessed by tissue Doppler imaging in patients with obstructive sleep apnoea syndrome. | In this study, we aimed to assess left ventricular (LV) systolic and diastolic functions by tissue Doppler imaging (TDI) in patients with obstructive sleep apnoea syndrome (OSAS) and to investigate the effects of 6 month continuous positive airway pressure (CPAP) on LV systolic and diastolic functions. We studied 28 ne... | 18,845,553 |
Targeting calcium handling in arrhythmias. | Abnormal calcium (Ca) handling can contribute to arrhythmogenesis directly by triggering abnormal depolarizations and indirectly by modulating action potential time course and duration. Recent data have shown the importance of these mechanisms in rare genetic diseases but also in more common conditions such as heart fa... | 18,845,561 |
Interplay of RNA Pol IV and ROS1 during post-embryonic 5S rDNA chromatin remodeling. | We have investigated the chromatin structure of 5S rDNA, a heterochromatic pericentromeric tandemly repeated family, at 2, 3, 4 and 5 days post-germination. Our results revealed a large-scale reorganization of 5S rDNA chromatin that occurs during the first days of development. Unexpectedly, there is a decondensation fo... | 18,845,569 |
Stochastic dynamics of genetic networks: modelling and parameter identification. | Identification of regulatory networks is typically based on deterministic models of gene expression. Increasing experimental evidence suggests that the gene regulation process is intrinsically random. To ensure accurate and thorough processing of the experimental data, stochasticity must be explicitly accounted for bot... | 18,845,579 |
Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats. | Postural muscle tone is potently suppressed during sleep and cataplexy. Since brainstem noradrenergic cell discharge activity is tightly coupled with state-dependent changes in muscle activity, it is assumed that noradrenergic drive on to somatic motoneurones modulates basal muscle tone. However, it has never been dete... | 18,845,613 |
The role of glycosphingolipid metabolism in the developing brain. | Glycosphingolipids (GSLs) are amphipathic lipids ubiquitously expressed in all vertebrate cells and body fluids, but they are especially abundant in the nervous system. The synthesis of GSLs generally is initiated in the endoplasmic reticulum and completed in the Golgi apparatus, followed by transportation to the plasm... | 18,845,618 |
Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. | Myostatin, a member of the TGF-beta superfamily of proteins, is known to suppress skeletal muscle mass and myocyte proliferation. The muscular component of the uterus is the myometrium, a tissue that regulates its mass in response to different physiological conditions under the influence of sex steroids. Recently, our ... | 18,845,635 |
Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. | Using long-term streptozotocin (STZ)-treated male rats, we recently proposed that defective function of hypothalamic KiSS-1 system is mechanistically relevant for central hypogonadotropism of uncontrolled diabetes. However, the temporal pattern of such defects and its potential contribution to disturbed gonadotropin se... | 18,845,637 |
Transcription of steroidogenic acute regulatory protein in the rodent ovary and placenta: alternative modes of cyclic adenosine 3', 5'-monophosphate dependent and independent regulation. | Steroid hormone synthesis is a vital function of the adrenal cortex, serves a critical role in gonadal function, and maintains pregnancy if normally executed in the placenta. The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholesterol... | 18,845,640 |
Endothelial dysfunction in mice with streptozotocin-induced type 1 diabetes is opposed by compensatory overexpression of cyclooxygenase-2 in the vasculature. | Cardiovascular complications of diabetes result from endothelial dysfunction secondary to persistent hyperglycemia. We investigated potential compensatory mechanisms in the vasculature that oppose endothelial dysfunction in diabetes. BALB/c mice were treated with streptozotocin (STZ) to induce type 1 diabetes (T1D). In... | 18,845,644 |
High frequency of adverse health behaviors in multiple sclerosis. | Health behaviors influence chronic disease risks in the general population, and may influence health outcomes independently of comorbid diseases. Health behaviors receive less attention in multiple sclerosis (MS) than in the general population. We assessed health behaviors among participants in the North American Resea... | 18,845,651 |
The distribution of new enhancing lesion counts in multiple sclerosis: further explorations. | A statistical distribution describing the number of new enhancing lesions seen on MRI in patients with MS is of great importance for improving the statistical methodology of clinical trials using new enhancing lesions as outcome measure. We examined whether there are superior alternatives for the currently proposed neg... | 18,845,655 |
Cytoskeleton interruption in human hepatoma HepG2 cells induced by ketamine occurs possibly through suppression of calcium mobilization and mitochondrial function. | Ketamine is an intravenous anesthetic agent often used for inducing and maintaining anesthesia. Cytoskeletons contribute to the regulation of hepatocyte activity of drug biotransformation. In this study, we attempted to evaluate the effects of ketamine on F-actin and microtubular cytoskeletons in human hepatoma HepG2 c... | 18,845,661 |
Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. | Diclofenac is an important analgesic and anti-inflammatory drug, widely used for treatment of postoperative pain, rheumatoid arthritis, and chronic pain associated with cancer. Consequently, diclofenac is often used in combination regimens and undesirable drug-drug interactions may occur. Because many drug-drug interac... | 18,845,662 |
Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast. | The temporal phosphorylation of cell cycle-related proteins by cyclin-dependent kinases (Cdks) is critical for the correct order of cell cycle events. In budding yeast, CDC28 encodes the only Cdk and its association with various cyclins governs the temporal phosphorylation of Cdk substrates. S-phase Cdk substrates are ... | 18,845,678 |
The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats. | A brief period of global brain ischemia, such as that induced by cardiac arrest or cardiopulmonary bypass surgery, causes cell death in vulnerable hippocampal CA1 pyramidal neurons days after reperfusion. Although numerous factors have been suggested to account for this phenomenon, the mechanisms underlying it are poor... | 18,845,684 |
Update on a clinical measure for the assessment of problem solving. | The Rapid Assessment of Problem Solving test (RAPS) is a clinical measure of problem solving based on the 20 Questions Test. This article updates clinicians on the RAPS, addresses questions raised about the test in an earlier article (R. C. Marshall, C. M. Karow, C. Morelli, K. Iden, & J. Dixon, 2003a), and discuss... | 18,845,695 |
Environmental genomics reveals a single-species ecosystem deep within Earth. | DNA from low-biodiversity fracture water collected at 2.8-kilometer depth in a South African gold mine was sequenced and assembled into a single, complete genome. This bacterium, Candidatus Desulforudis audaxviator, composes >99.9% of the microorganisms inhabiting the fluid phase of this particular fracture. Its gen... | 18,845,759 |
Ibn al-Nafis, the pulmonary circulation, and the Islamic Golden Age. | Ibn al-Nafis (1213-1288) was an Arab physician who made several important contributions to the early knowledge of the pulmonary circulation. He was the first person to challenge the long-held contention of the Galen School that blood could pass through the cardiac interventricular septum, and in keeping with this he be... | 18,845,773 |
Individualization of transfer function in estimation of central aortic pressure from the peripheral pulse is not required in patients at rest. | Central aortic pressure gives better insight into ventriculo-arterial coupling and better prognosis of cardiovascular complications than peripheral pressures. Therefore transfer functions (TF), reconstructing aortic pressure from peripheral pressures, are of great interest. Generalized TFs (GTF) give useful results, es... | 18,845,775 |
A further analysis of why pulmonary venous pressure rises after the onset of LV dysfunction. | Based on a dynamic computational model of the circulation, Burkhoff and Tyberg (Am J Physiol Heart Circ Physiol 265: H1819-H1828, 1993) concluded that the rise in pulmonary venous pressure (Pvp) with left ventricular (LV) dysfunction requires a decrease in vascular capacitance and transfer of unstressed volume to stres... | 18,845,783 |
Outcrossing as an explanation of the apparent unconventional genetic behavior of Arabidopsis thaliana hth mutants. | The reappearance of HTH alleles in the offspring of homozygous Arabidopsis hth mutants is not consistent with classical Mendelian genetics. It has been suggested that stored RNA may be used to restore genetic information. However, Peng et al. reported that hth mutants tend to display outcrossing and suggested that outc... | 18,845,842 |
The effect of hydrodynamic flow regimes on the algal bloom in a monomictic reservoir. | The effectiveness of a proposed curtain weir to be installed in the transitional zone of a eutrophic reservoir located in monsoon areas on the control of algal blooms in the lacustrine zone where drinking water withdrawals occur was assessed with various hydrodynamic flow regimes. A two-dimensional hydrodynamic and eut... | 18,845,869 |
Micro-solvent cluster extraction using aqueous mixed solvents of ionic liquid. | Organic compounds (2-naphthol, phenol, 4-chlorophenol, 4-nitrophenol, and 1,3,5-naphthalenetrisulfonic acid) were sufficiently separated from mixtures during flow in a fused silica capillary tube (50 microm in i.d. and 45 cm in length) with an aqueous mixed solvent of an ionic liquid, 1-butyl-3-methylimidazolium chlori... | 18,845,880 |
Aggregation of imidazolium ionic liquids in molecular liquids studied by small-angle neutron scattering and NMR. | The aggregation of two imidazolium-based ionic liquids, 1-ethly-3-methylimidazolium chloride (EMI(+)Cl(-)) and EMI(+) bis-(trifluoromethanesulfonyl)amide (EMI(+)TFSA(-)), in molecular liquids, water, methanol, acetonitrile, and benzene, has been studied by using the small-angle neutron scattering (SANS) technique. The ... | 18,845,888 |
Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation. | To explore the cellular effects of mild electrical stimulation (MES), we treated A549 cells with low-intensity direct current at 5 V applied for 10 min. MES did not induce cell cytotoxicity or the unfolded protein response (UPR). Interestingly, the expression of ubiquitinated proteins and heat shock protein (Hsp) 72 wa... | 18,845,908 |
Public health practice vs research: implications for preparedness and disaster research review by State Health Department IRBs. | Under the current US Department of Health and Human Services regulatory and ethical system for research involving human subjects, research is defined in terms of several key concepts: intent, systematic investigation, and generalizability. If an investigator engages in a systematic investigation designed or intended to... | 18,845,930 |
Rapid CD4+ cell decrease after transient cART initiated during primary HIV infection (ANRS PRIMO and SEROCO cohorts). | To modelize the rate of CD4 cell count decline and its determinants after cessation of combination antiretroviral therapy (cART) started during primary HIV infection (PHI) and compare it with never-treated patients. Kinetics of CD4 counts were analyzed on the square root scale by using a mixed-effects model in 170 pati... | 18,845,951 |
Influences of normobaric hypoxia training on metabolic risk markers in human subjects. | Endurance exercise and hypoxia regulate pathways that are crucial to glucose and lipid metabolism. We hypothesized that training under hypoxia results in similar or even greater metabolic improvement compared with exercise under normoxia at a lower workload. We randomly assigned 20 healthy men to single blind training ... | 18,845,972 |
No influence of noradrenaline manipulation on acute exercise-induced increase of brain-derived neurotrophic factor. | To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF). In a double-blind, placebo-controlled, crossover design, 11 young, healthy male subjects were treated with either placebo or reboxetine. On each occas... | 18,845,978 |
Pneumonia after implementation of the pneumococcal conjugate vaccine program in the province of Quebec, Canada. | In Canada, a pneumococcal conjugate vaccine was licensed in 2001, and in the province of Quebec, a publicly-funded program was implemented for high-risk children in 2002, using a 4-dose schedule, and for all children in 2004, using a 3-dose schedule. To describe the epidemiology of hospitalized pneumonia in the populat... | 18,845,982 |
Quantitative PCR assay used to monitor serum Trichosporon asahii DNA concentrations in disseminated trichosporonosis. | A bone marrow transplant recipient with disseminated trichosporonosis was successfully treated with voriconazole. Quantitative PCR assay results for Trichosporon asahii DNA in the sera were well correlated with the patient's clinical course. Based on the in vitro susceptibility test, the organism was susceptible to vor... | 18,845,986 |
Age and grade trends in prostate cancer (1974-2003): a Surveillance, Epidemiology, and End Results Registry analysis. | Age and pathologic grade are 2 critical factors used to guide clinical decisions and comparative outcomes studies in prostate cancer. The objective of this investigation was to use the Surveillance, Epidemiology, and End Results (SEER) registry to examine time trends in age and grade. The SEER public-use registry was q... | 18,845,997 |
Apoptosis and cell proliferation: the paradox of salivary glands in Sjögren's disease. | To assess apoptosis and proliferation in salivary glands of patients with primary Sjögren's syndrome. Studies were performed in twenty four minor salivary glands from patients with primary Sjögren's syndrome and an equal number of controls. Apoptosis was studied by immunohistochemistry using monoclonal antibodies anti-... | 18,846,009 |
Testosterone therapy improves the clinical response to conventional treatment for male patients with metabolic syndrome associated to late onset hypogonadism. | Recently, the clinic characterization of the gonadic male function has been put in tight correlation on the pathogenetic level with the main variables forming the condition of metabolic syndrome (MS); probably the serum testosterone (T) concentration in males is to be considered as an additional parameter completely re... | 18,846,023 |
PET imaging in neuroendocrine tumors: current status and future prospects. | Neuroendocrine tumors (NET) are relatively rare diverse group of tumors that possess several unique characteristics and occur most commonly in the gastrointestinal tract. An important feature of these tumors is that they express somatostatin (SST) receptors, and thus can be successfully targeted with specific radiolabe... | 18,846,029 |
Age at arrival and risk of obesity among US immigrants. | Although immigrants are a rapidly growing subgroup, little is known about overweight/obesity among the foreign-born in the United States, especially regarding the effect of age at arrival. This study determined whether overweight/obesity prevalence is associated with age at arrival of immigrants to the United States. W... | 18,846,044 |
hnRNP A1 regulates UV-induced NF-kappaB signalling through destabilization of cIAP1 mRNA. | cIAP1 is an important member of the inhibitor of apoptosis family of proteins and is involved in the regulation of the NF-kappaB-signalling pathway downstream of the TNF receptor. We report here that UV irradiation leads to downregulation of cIAP1 expression because of enhanced cIAP1 mRNA destabilization. An AU-rich el... | 18,846,111 |
[Seizure exacerbation caused by antiepileptic drugs]. | In certain types of epilepsy, antiepileptic drugs can exacerbate the disease instead of improving it. This review is based on a non-systematic literature search in Medline for the time-period 1990-2007, and our own clinical experience. As a consequence of treatment with antiepileptic drugs, patients with epilepsy may h... | 18,846,119 |
[Motor symptoms in Parkinson disease]. | Early Parkinson's disease is dominated by a motor syndrome called parkinsonism, but as the disease develops motor complications and non-motor problems may occur as well. This paper describes how to diagnose Parkinson's disease and the various motor complications and gives recommendations on how to treat the symptoms in... | 18,846,123 |
[Neuropsychiatric and cognitive symptoms in Parkinson disease]. | A variety of neuropsychiatric symptoms commonly occur in Parkinson's disease. Extensive research the last 10 years has provided new knowledge in the field. This review is based on literature retrieved from a Medline search and own research and clinical experience. Neuropsychiatric symptoms occur in the majority of pati... | 18,846,124 |
Segment Coupling to a Highly Hindered N-Terminal, Alamethicin-Related alpha-Aminoisobutyric Acid (Aib) Residue. | A model [6 + 5] segment coupling process involving a C-terminal valine hexapeptide acid and a resin-attached pentapeptide amide which N-terminated in a hindered Aib unit was examined using a variety of HOAt-derived coupling reagents. Best results were observed with HAPyU in DCM solvent in which loss of configuration am... | 18,846,198 |
Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis. | The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism. Here we study the impact of the limited solvent capacity constraint on the metabolic rate, enzyme activities, ... | 18,846,199 |
Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping. | Refractive error is a highly heritable quantitative trait responsible for considerable morbidity. Following an initial genome-wide linkage study using microsatellite markers, we confirmed evidence for linkage to chromosome 3q26 and then conducted fine-scale association mapping using high-resolution linkage disequilibri... | 18,846,214 |
Time to Guide: Evidence for Delayed Attentional Guidance in Contextual Cueing. | Contextual cueing experiments show that, when displays are repeated, reaction times (RTs) to find a target decrease over time even when the observers are not aware of the repetition. Recent evidence suggests that this benefit in standard contextual cueing tasks is not likely to be due to an improvement in attentional g... | 18,846,248 |
Male behavioural maturation rate responds to selection on pollen hoarding in honeybees. | Division of labour in social insect colonies relies on behavioural functional differentiation (specialization) of individuals with similar genomes. However, individual behavioural traits do not evolve independently of each other (behavioural syndromes). A prime example is the suite of behavioural differences in honeybe... | 18,846,249 |
Low-dose-radiation stimulated natural chemical and biological protection against lung cancer. | Research is being conducted world-wide related to chemoprevention of future lung cancer among smokers. The fact that low doses and dose rates of some sparsely ionizing forms of radiation (e.g., x rays, gamma rays, and beta radiation) stimulate transient natural chemical and biological protection against cancer in high-... | 18,846,259 |
Infliximab for pediatric Crohn's disease. | The natural history of Crohn's disease (CD) is characterized by recurrent flares combined with periods of inactive disease. The goal of therapy should be to induce and maintain clinical remission, to strive for endoscopic healing of the intestinal mucosa and to improve the quality of life. The nineties have been charac... | 18,846,272 |
Capecitabine in gastric cancer. | Double and triplet regimens comprising a fluoropyrimidine and a platinum compound, with or without an anthracycline or taxane are accepted standards of care for advanced gastric cancer. Capecitabine, an oral fluoropyrimidine designed to selectively deliver 5-fluorouracil (5-FU) to tumor cells, is safe and effective in ... | 18,846,273 |
Synthesis of pyrazole substituted methyl pheophorbide-a derivatives and their preliminary in vitro cell viabilities. | The unique ability of chlorophyll derivatives to accumulate in tumorous tissues and to cause a photodynamic effect under laser radiation has been successively used in photodynamic therapy. In this connection, enormous research on modifications of the peripheral substituents in chlorophyll has shown that the presence an... | 18,846,294 |
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