title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Chromatin-modifying enzymes as therapeutic targets--Part 2. | Part 1 of this review described the importance of histone acetylases, deacetylases, methylases and demethylases in transcriptional control and their potential as therapeutic targets. However, precise gene regulation requires the involvement of more than just the addition or removal of acetyl and methyl groups on histon... | 18,851,700 |
Dynamics of liquids, molecules, and proteins measured with ultrafast 2D IR vibrational echo chemical exchange spectroscopy. | A wide variety of molecular systems undergo fast structural changes under thermal equilibrium conditions. Such transformations are involved in a vast array of chemical problems. Experimentally measuring equilibrium dynamics is a challenging problem that is at the forefront of chemical research. This review describes ul... | 18,851,709 |
Hypobromous acid and bromamine production by neutrophils and modulation by superoxide. | MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate to their respective hypohalous acids. We have investigated the generation of HOBr by human neutrophils in the presence of physiological concentrations of chloride and bromide. HOBr was trapped with taurine and detected by monitoring the ... | 18,851,713 |
The usefulness of contrast during exercise echocardiography for the assessment of systolic pulmonary pressure. | The systolic pulmonary artery pressure (PAPs) can be accurately estimated, non-invasively, using continuous-wave Doppler (CWD) ultrasound measurement of the peak velocity of a tricuspid regurgitant (TR) jet. However, it is often difficult to obtain adequate tricuspid regurgitation signals for measurement of PAPs, what ... | 18,851,729 |
Transposition of the great arteries. | Transposition of the great arteries (TGA), also referred to as complete transposition, is a congenital cardiac malformation characterised by atrioventricular concordance and ventriculoarterial (VA) discordance. The incidence is estimated at 1 in 3,500-5,000 live births, with a male-to-female ratio 1.5 to 3.2:1. In 50% ... | 18,851,735 |
Sample processing for DNA chip array-based analysis of enterohemorrhagic Escherichia coli (EHEC). | Exploitation of DNA-based analyses of microbial pathogens, and especially simultaneous typing of several virulence-related genes in bacteria is becoming an important objective of public health these days. A procedure for sample processing for a confirmative analysis of enterohemorrhagic Escherichia coli (EHEC) on a sin... | 18,851,736 |
Probabilistic base calling of Solexa sequencing data. | Solexa/Illumina short-read ultra-high throughput DNA sequencing technology produces millions of short tags (up to 36 bases) by parallel sequencing-by-synthesis of DNA colonies. The processing and statistical analysis of such high-throughput data poses new challenges; currently a fair proportion of the tags are routinel... | 18,851,737 |
Delayed involution of lactation presenting as a non-resolving breast mass: a case report. | Involution of lactation is a physiological process. Rarely, it may be delayed and troublesome for the lactating woman. Though lactation-induced changes in breast are well known, morphological features of delayed involution are not clear. We report a case of a 22-year-old lactating mother who presented with a painful, n... | 18,851,738 |
Patterns of hand preference for pairs of actions and the classification of handedness. | Pairs of actions such as write x throw and throw x racquet were examined for items of the Annett hand preference questionnaire (AHPQ). Right (R) and left (L) responses were described for frequencies of RR, RL, LR, and LL pairings (write x throw etc.) in a large representative combined sample with the aim of discovering... | 18,851,767 |
[Specific antitumor effect of adeno-associated virus vector carrying TRAIL gene under the control of hTERT promoter]. | Adeno-associated virus (AAV) has been widely used in tumor gene therapy. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a safe and potent anti-tumor gene which could induce apoptosis of many tumor cells. This study was to use tumor-specific promoter hTERT to construct AAV-hTERT-TRAIL, and explore it... | 18,851,780 |
[Inhibitory effect of N-terminal 24 amino acids of the p55 gamma, a regulatory subunit of phosphoinositide 3-kinase, on proliferation of colon carcinoma cell line HT29]. | p55 gamma is one of the regulatory subunits of phosphoinositide 3-kinase (PI3K), which plays an important role in the regulation of PI3K activity. This study was to explore the inhibitory effect of the N-terminal 24 amino acids of the p55 gamma on proliferation of colon carcinoma cell line HT29. Ad-N24p55-GFP, containi... | 18,851,781 |
Clinical applications of bone morphogenetic proteins: current evidence. | Bone morphogenetic proteins (BMPs) were first described by Dr. Marshall Urist in 1965. Since 1988 a series of clinical studies and randomized clinical trials have evaluated the application of these molecules in humans. A comprehensive review of 30 clinical studies was performed to elicit the existing evidence of the En... | 18,851,797 |
Rate and risk factors for blood transfusion in patients undergoing periacetabular osteotomy. | Periacetabular osteotomy has become the procedure of choice in many centers for the treatment of symptomatic hip dysplasia in young patients without severe secondary hip arthritis. Reorientation pelvic osteotomy has the potential for large blood loss and the need for blood transfusion. Between 1996 and 2003, 108 periac... | 18,851,804 |
Late postoperative infection following spinal instrumentation: stainless steel versus titanium implants. | Late postoperative infection following instrumented spinal surgery is a clinical entity that has emerged in recent years. The extended surface of the spinal instrumentation in combination with hematogenous seeding or intraoperative inoculation is the main predisposing factor. In order to investigate the contribution of... | 18,851,806 |
Lateral and medial plantar pressures after split versus whole anterior tibialis tendon transfer. | If whole and split transfer of the anterior tibialis tendon (SPLATT) do not differ in balancing the forefoot, whole tendon transfer would provide a simpler alternative as part of treatment of an equinovarus deformity. We hypothesized that no significant differences in percent plantar lateral forefoot pressures would be... | 18,851,822 |
MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF. | Mixed lineage kinase 3 (MLK3) is a MAP3K that activates the JNK-dependent MAPK pathways. Here, we show that MLK3 is required for cell migration in a manner independent of its role as a MAP3K or MLK3 kinase activity. Rather, MLK3 functions in a regulated way to limit levels of the activated GTPase Rho by binding to the ... | 18,851,832 |
RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. | RBM5/Luca-15/H37 is a gene frequently inactivated in lung cancers and overexpressed in breast tumors. Its protein product has been detected in prespliceosomal complexes and modulates cell proliferation and Fas-mediated apoptosis. We report that RBM5 is a component of complexes involved in 3' splice site recognition and... | 18,851,835 |
MyoD targets TAF3/TRF3 to activate myogenin transcription. | Skeletal muscle differentiation requires a cascade of transcriptional events to control the spatial and temporal expression of muscle-specific genes. Until recently, muscle-specific transcription was primarily attributed to prototypic enhancer-binding factors, while the role of core promoter recognition complexes in di... | 18,851,836 |
An examination of the interactions between mothers and children with anxiety disorders. | This study examined the association between parenting styles and mother and child anxiety. Maternal overinvolvement and negativity/criticism were evaluated during a speech preparation task (N=135 dyads) and a Five Minute Speech Sample (FMSS) from mothers (N=155). During the speech task interaction, mothers of anxious c... | 18,851,844 |
Serum progesterone on the day of human chorionic gonadotropin administration predicts clinical pregnancy of sibling frozen embryos. | To evaluate patient characteristics and fresh in vitro fertilization (IVF) cycle parameters that influence success of sibling frozen-thawed embryo transfer (FET) cycles. Retrospective study. Academic infertility practice. Infertile women undergoing FET cycles using embryos cryopreserved on day 3 after insemination afte... | 18,851,847 |
Effect of oral N-acetyl cysteine on recurrent preterm labor following treatment for bacterial vaginosis. | To evaluate the effect of N-acetyl cysteine (NAC) on gestational age at delivery in women with previous preterm labor and bacterial vaginosis. A randomized, double-blind, placebo-controlled trial with 280 women between 16 and 18 weeks of pregnancy who had 1 previous preterm birth and had just been successfully treated ... | 18,851,855 |
Polybrominated diphenyl ether flame retardants in lichens and mosses from King George Island, maritime Antarctica. | Lichens and mosses are considered good indicators of atmospheric pollution as they absorb contaminants directly from the air. Polybrominated diphenyl ethers (PBDEs) are man-made chemicals used as flame retardants in materials such as plastics, textiles, electronic circuitry and furnishing foam. Few studies have investi... | 18,851,870 |
The control of dendritic cell maturation by pH-sensitive polyion complex micelles. | Double-hydrophilic block copolymer micelles were designed as vectors for ex vivo dendritic cell engineering to improve the delivery of therapeutic molecules in such immune cells. Polymethacrylic acid-b-polyethylene oxide (PMAA(2100)-b-POE(5000))/poly-L-lysine micelles were optimised and showed a hydrodynamic diameter o... | 18,851,879 |
The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma. | Human hepatocellular carcinoma (HCC) is one of the major causes of death worldwide. Targeted uptake of therapeutic agent in the cell-, tissue- or disease-specific manner represents a potential technology for the treatment of HCC. A new docetaxel-loaded hepatoma-targeted solid lipid nanoparticle (tSLN) was designed and ... | 18,851,881 |
A prospective study of hormonal treatment and anxiety disorders in community-dwelling elderly women (the Esprit Study). | The impact of hormone therapy use on late-life anxiety disorder in elderly women has not been evaluated. Anxiety disorders were evaluated in 838 community-dwelling postmenopausal women aged 65 years and over, randomly recruited from electoral rolls. Anxiety disorders were assessed using a standardized psychiatric exami... | 18,851,886 |
"So, are you back to work yet?" Re-conceptualizing 'work' and 'return to work' in the context of primary bone cancer. | People with primary bone cancer typically are young (usual age-at-onset 16-35 years old) and undergo arduous treatments. The current standard of care (tumour resection and limb reconstruction with or without chemotherapy) results in survival rates in excess of 60%, but also results in significant disability at a time w... | 18,851,893 |
The effect of tianeptine in the prevention of radiation-induced neurocognitive impairment. | Radiation-induced neurocognitive impairment is an undesirable radiation-induced toxicity and a common health problem in patients with primary or metastatic brain tumor. It greatly impairs quality of life for long-term brain tumor survivors. Hippocampus is the most important brain structure for neurocognitive functions.... | 18,851,901 |
Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. | A series of tetrakis-azaaromatic quaternary ammonium salts was synthesized to identify compounds with higher affinity and selectivity as antagonists at neuronal nicotinic receptor subtypes (nAChR) that mediate nicotine-evoked DA release. A high hit rate was achieved in identifying potent analogs that inhibit these nACh... | 18,851,914 |
The first intermediate host of Paragonimus westermani in Sri Lanka. | Freshwater snails (family Paludomidae, genus Paludomus) were collected from streams in Hedeniya and Peradeniya (the campus of Peradeniya University), Kandy district, Central Province, Sri Lanka, and found to harbor rediae and cercariae of a Paragonimus sp. These larvae were identified as Paragonimus westermani by using... | 18,851,937 |
ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. | This study investigated the effects of atorvastatin on ABCB1 and ABCC1 mRNA expression on peripheral blood mononuclear cells (PBMC) and their relationship with gene polymorphisms and lowering-cholesterol response. One hundred and thirty-six individuals with hypercholesterolemia were selected and treated with atorvastat... | 18,851,956 |
Monitoring the tobacco use epidemic III: The host: data sources and methodological challenges. | This Host paper (III of V) reviews key surveillance and evaluation systems that monitor the characteristics, attitudes and behaviors of tobacco users that are crucial for tobacco control efforts. We summarize and expand on the recommendations from the Host Working Group of the National Tobacco Monitoring, Research and ... | 18,851,990 |
Validation of a virus neutralization potency test in BHK-21 cells for rabies immunoglobulins in a two-center study. | A rabies virus neutralization potency test (VNPT), adapted to microplates from the rapid fluorescent focus inhibition test (RFFIT) for rabies therapeutic immunoglobulin potency evaluation, was standardized and validated in a two-center study in Brazil. The two institutes involved in the study were: Instituto Nacional d... | 18,851,992 |
Biofilm production, a marker of pathogenic potential of colonizing and commensal staphylococci. | Biofilm is one of the known virulence factors of staphylococci, a human and animal pathogen and commensal. Some of the strains become invasive under favorable conditions while others do not cause disease. Early detection and management of potentially pathogenic staphylococci is the essential step to prevent device-asso... | 18,851,996 |
Differences of humoral and cellular immune response to an acellular pertussis booster in adolescents with a whole cell or acellular primary vaccination. | To study the pertussis-specific immune response of adolescents with different prevaccination schedules, we measured the humoral and cell-mediated immunity (CMI) to pertussis antigens before and after a five-component Tdap booster vaccination in 78 adolescents, who had previously received either five doses of a two-comp... | 18,852,002 |
Effects of o-aminoazotoluene on liver regeneration and p53 activation in mice susceptible and resistant to hepatocarcinogenesis. | The susceptibility to hepatocellular carcinoma (HCC) varies greatly within human populations in response to environmental risk agents. The mechanisms underlying differential susceptibility are still largely unknown and need to be clarified to improve HCC chemoprevention and therapeutic treatment. Inbred rodent strains ... | 18,852,010 |
The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization. | Many biological actions of Pimpinella anisum L. (Ainse), including antiepileptic activity have been demonstrated; however, there is no data concerning its precise cellular mechanisms of action. We determined whether the fruit essential oil of anise affect the bioelectrical activity of snail neurons in control condition... | 18,852,037 |
Evaluation of anti-inflammatory and antinociceptive activities of some Onosma L. species growing in Turkey. | Roots of Onosma species are used for the treatment of various disorders such as bronchitis, tonsillitis, hemorrhoids as well as alleviating pains in folk medicine in Turkey. The chloroform and ethanol (70%) extracts obtained from the roots of Onosma species (Boraginaceae) growing in Turkey, Onosma aucheranum DC., Onosm... | 18,852,039 |
Insular cortex representation of dynamic mechanical allodynia in trigeminal neuropathic rats. | Dynamic mechanical allodynia is a widespread symptom of neuropathic pain for which mechanisms are still poorly understood. The present study investigated the organization of dynamic mechanical allodynia processing in the rat insular cortex after chronic constriction injury to the infraorbital nerve (IoN-CCI). Two weeks... | 18,852,047 |
Functional and structural synergy for resolution recovery and partial volume correction in brain PET. | Positron Emission Tomography (PET) has the unique capability of measuring brain function but its clinical potential is affected by low resolution and lack of morphological detail. Here we propose and evaluate a wavelet synergistic approach that combines functional and structural information from a number of sources (CT... | 18,852,055 |
Increased spermine oxidase (SMO) activity as a novel differentiation marker of myogenic C2C12 cells. | Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal. In the present study, we have examined the SMO gene expression during the mouse myoblast C2C12 cell differentiation induced w... | 18,852,063 |
Chromosome aberrations in mouse embryos and fetuses produced by assisted reproductive technology. | The occurrence of structural chromosome aberrations in mouse one-cell embryos produced by intracytoplasmic sperm injection (ICSI) with mature spermatozoa was dependent on the type of sperm incubation medium and sperm incubation time. When cauda epididymal spermatozoa were used following incubation in bicarbonate-buffer... | 18,852,067 |
Small liver lesions in oncologic patients: characterization with CT, MRI and contrast-enhanced US. | Focal liver lesions (FLLs) are frequently discovered during ultrasound examinations either in healthy subjects without a clinical history of cancer or during staging or follow-up procedures in oncologic patients or in routine surveillance of hepatopathic patients. In oncologic patients, the liver is the most common tar... | 18,852,087 |
Surface temperatures of the Mid-Pliocene North Atlantic Ocean: implications for future climate. | The Mid-Pliocene is the most recent interval in the Earth's history to have experienced warming of the magnitude predicted for the second half of the twenty-first century and is, therefore, a possible analogue for future climate conditions. With continents basically in their current positions and atmospheric CO2 simila... | 18,852,090 |
Modelling heterotachy in phylogenetic inference by reversible-jump Markov chain Monte Carlo. | The rate at which a given site in a gene sequence alignment evolves over time may vary. This phenomenon--known as heterotachy--can bias or distort phylogenetic trees inferred from models of sequence evolution that assume rates of evolution are constant. Here, we describe a phylogenetic mixture model designed to accommo... | 18,852,097 |
Evaluating the robustness of phylogenetic methods to among-site variability in substitution processes. | Computer simulations provide a flexible method for assessing the power and robustness of phylogenetic inference methods. Unfortunately, simulated data are often obviously atypical of data encountered in studies of molecular evolution. Unrealistic simulations can lead to conclusions that are irrelevant to real-data anal... | 18,852,108 |
Class I beta-tubulin mutations in 2-methoxyestradiol-resistant acute lymphoblastic leukemia cells: implications for drug-target interactions. | 2-Methoxyestradiol (2ME2) is a naturally occurring derivative of estradiol that has been shown to be an active small molecule that has antitumor and antiangiogenic properties. 2ME2 binds to beta-tubulin near the colchicine-binding site, inhibits microtubule polymerization, and induces mitotic arrest. To improve underst... | 18,852,118 |
Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. | Androgen receptor (AR) is a ligand-activated transcription factor belonging to the steroid hormone receptor family and is very important for the development and progression of prostate cancer. The soy isoflavone genistein has been shown previously to down-regulate AR in androgen-dependent prostate cancer cell lines suc... | 18,852,123 |
Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. | All four members of the human epidermal growth factor (EGF) receptor (HER) family are implicated in human cancers. Although efficacious in a subset of patients, resistance to single-targeted anti-HER therapy [i.e., cetuximab (Erbitux) and trastuzumab (Herceptin)] is often associated with coexpression of other HER famil... | 18,852,126 |
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis. | Compounds isolated from members of the Zingiberaceae family are traditionally used as a medicine against inflammatory diseases, but little is known about the mechanism. Here, we report the isolation and structural identification of coronarin D [E-labda-8(17),12-diene-15-ol], a labdane-type diterpene, from Hedychium cor... | 18,852,134 |
Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition. | Fibroblast growth factors (FGF) and their high-affinity receptors (FGFR) represent an extensive cellular growth and survival system. Aim of this study was to evaluate the contribution of FGF/FGFR-mediated signals to the malignant growth of non-small cell lung cancer (NSCLC) and to assess their potential as targets for ... | 18,852,144 |
Accounting for ancestry: population substructure and genome-wide association studies. | Accounting for the genetic substructure of human populations has become a major practical issue for studying complex genetic disorders. Allele frequency differences among ethnic groups and subgroups and admixture between different ethnic groups can result in frequent false-positive results or reduced power in genetic s... | 18,852,203 |
Genome-based prediction of common diseases: advances and prospects. | Common diseases such as type 2 diabetes and coronary heart disease result from a complex interplay of genetic and environmental factors. Recent developments in genomics research have boosted progress in the discovery of susceptibility genes and fueled expectations about opportunities of genetic profiling for personaliz... | 18,852,206 |
Patients with familial and sporadic onset SLE have similar clinical profiles but vary profoundly by race. | Few large, multi-ethnic studies have examined the clinical and serologic differences between familial and sporadic SLE patients. Understanding these similarities and differences is critical for interpreting genetic studies and developing therapeutic strategies. We compiled information on 1915 patients with SLE in a lar... | 18,852,224 |
Changes in body composition after glucocorticoid therapy in patients with systemic lupus erythematosus. | The aim of this study was to evaluate the changes in body composition after glucocorticoid treatment in patients with systemic lupus erythematosus (SLE). Consecutive SLE patients were recruited for serial measurements (baseline, months 2 and 6) of bone mineral density (BMD) and body composition [bone mineral content (B... | 18,852,226 |
Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia. | Pneumonia caused by Staphylococcus aureus is a growing concern in the health care community. We hypothesized that characterization of the early innate immune response to bacteria in the lungs would provide insight into the mechanisms used by the host to protect itself from infection. An adult mouse model of Staphylococ... | 18,852,243 |
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. | Vascular calcification (VC) is highly correlated with increased morbidity and mortality in advanced chronic kidney disease (CKD) patients. Allosteric modulation of the calcium-sensing receptor (CaR) by calcimimetics inhibits VC in animal models of advanced CKD. Here, we investigated the expression of the CaR in the vas... | 18,852,253 |
KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. | Carbapenemases are among the newest resistance mechanisms to emerge in some gram-negative bacteria. We describe bacteremia in a critically ill liver transplant recipient infected with KPC-2-producing Enterobacter cloacae and Pseudomonas putida. Although this enzyme has been previously described in Enterobacter spp., th... | 18,852,270 |
Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity. | Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA(1-7) M(2-9) (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resultin... | 18,852,279 |
BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells. | During T helper cell differentiation, distinct programs of gene expression play a key role in defining the immune response to an environmental challenge. How chromatin remodeling events at the associated cytokine loci control differentiation is not known. We found that the ATP-dependent remodeling enzyme subunit BRG1 w... | 18,852,284 |
The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage. | Hint1 is a haploinsufficient tumor suppressor gene and the underlying molecular mechanisms for its tumor suppressor function are unknown. In this study we demonstrate that HINT1 participates in ionizing radiation (IR)-induced DNA damage responses. In response to IR, HINT1 is recruited to IR-induced foci (IRIF) and asso... | 18,852,295 |
Telepathology training in a master of cytology degree course. | We have investigated the changes in the workflow of the cytologist due to the introduction of telepathology. These changes occur in two stages. The first is the use of telepathology as a support methodology using external providers (i.e. outside the hospital) to digitize the slides. The second is the use of telepatholo... | 18,852,312 |
The role of technology in video-mediated consensus meetings. | We have studied the use of video-mediated technology to facilitate multidisciplinary meetings where consensus is reached about the diagnosis and treatment of patients. The meetings involved 2-5 sites, with 1-20 participants from each site, and concerned patients with severe diseases in the upper abdomen. During a perio... | 18,852,315 |
Identity-management factors in e-health and telemedicine applications. | Reliable identification is essential in e-health and telemedicine applications. This necessitates a secure and trustworthy method of communication and collaboration between parties, which depends on common acceptance. This in turn is related to privacy and ethical matters. Different technologies, including biometrics a... | 18,852,323 |
Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action. | Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in ... | 18,852,328 |
The spectrum of parkinsonian manifestations associated with glucocerebrosidase mutations. | Mutations in the glucocerebrosidase gene (GBA) result in Gaucher disease and can be associated with a phenotype characterized by adult-onset progressive neurologic deterioration and parkinsonism. To define the clinical and neurologic spectrum of parkinsonian manifestations associated with GBA mutations. Design, Setting... | 18,852,351 |
Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. | Preeclampsia is pregnancy-specific, affecting 2% to 7% of women, and is a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease. Selenium, acting through the selenoprotein glutathione peroxidases, has critical roles... | 18,852,388 |
The effect of smoking in midlife on health-related quality of life in old age: a 26-year prospective study. | Smoking shortens life expectancy by 7 to 10 years. However, it is unclear whether the enhanced longevity of nonsmokers produces increased disability and decreased quality of life during these extra final years. This study evaluates the long-term effect of smoking in midlife on health-related quality of life (HRQoL) in ... | 18,852,397 |
Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. | Prospective data relating caffeine consumption to breast cancer risk are limited. We evaluated the association between caffeine consumption and breast cancer risk in women enrolled in a completed cancer prevention trial. Detailed dietary information was obtained at baseline (1992-1995) from 38 432 women 45 years or old... | 18,852,405 |
Risk of admission to a nursing home among older people with visual impairment in Great Britain. | To assess the risk of nursing home admission in a representative sample of older, visually impaired, community-dwelling people 75 years and older living in Great Britain. Prospective study. General practices (n = 53). Participants in the Medical Research Council trial of assessment and management of older people in the... | 18,852,422 |
Herpetic encephalitis is a risk factor for acute retinal necrosis. | Acute retinal necrosis (ARN) has been observed in several cases after herpetic encephalitis (HE). ARN is a devastating ocular disease with a very disappointing visual outcome. Therefore, early recognition and diagnosis are crucial. To study the association between ARN and preceding neurologic illness, especially the co... | 18,852,442 |
DNA variation and symbiotic associations in phenotypically diverse sea urchin Strongylocentrotus intermedius. | Strongylocentrotus intermedius (A. Agassiz, 1863) is an economically important sea urchin inhabiting the northwest Pacific region of Asia. The northern Primorye (Sea of Japan) populations of S. intermedius consist of two sympatric morphological forms, "usual" (U) and "gray" (G). The two forms are significantly differen... | 18,852,450 |
Crystallographic snapshots of eukaryotic dimethylallyltransferase acting on tRNA: insight into tRNA recognition and reaction mechanism. | Hypermodifications near the anticodon of tRNA are fundamental for the efficiency and fidelity of protein synthesis. Dimethylallyltransferase (DMATase) catalyzes transfer of a dimethylallyl moiety from dimethylallyl pyrophosphate to N6 of A37 in certain tRNAs. Here we present the crystal structures of Saccharomyces cere... | 18,852,462 |
Theory, analysis, and interpretation of single-molecule force spectroscopy experiments. | Dynamic force spectroscopy probes the kinetic and thermodynamic properties of single molecules and molecular assemblies. Here, we propose a simple procedure to extract kinetic information from such experiments. The cornerstone of our method is a transformation of the rupture-force histograms obtained at different force... | 18,852,468 |
Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains. | T20 (generic name: Enfuvirtide, brand name: Fuzeon) is the only FDA-approved HIV fusion inhibitor that is being used for treatment of HIV/AIDS patients who have failed to respond to current antiretroviral drugs. However, it rapidly induces drug resistance in vitro and in vivo. On the basis of the structural and functio... | 18,852,475 |
Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes. | This work explores time-resolved emission imaging microscopy (TREM) for noninvasive imaging and mapping of live cells on a hitherto uncharted microsecond time scale. Simple robust molecules for this purpose have long been sought. We have developed highly emissive, synthetically versatile, and photostable platinum(II) c... | 18,852,476 |
Function of the Bacillus subtilis transcription elongation factor NusG in hairpin-dependent RNA polymerase pausing in the trp leader. | NusA and NusG are transcription elongation factors that bind to RNA polymerase (RNAP) after sigma subunit release. Escherichia coli NusA (NusA(Ec)) stimulates intrinsic termination and RNAP(Ec) pausing, whereas NusG(Ec) promotes Rho-dependent termination and pause escape. Both Nus factors also participate in the format... | 18,852,477 |
Bevacizumab improves the overall and progression-free survival of patients with metastatic colorectal cancer treated with 5-fluorouracil-based regimens irrespective of baseline risk. | Kohne et al. [Ann Oncol 2002;13:308-317] showed that four prognostic variables can be used to classify patients with metastatic colorectal cancer (CRC) treated with 5-fluorouracil (5-FU)/leucovorin (LV) into three risk groups with different overall survival (OS). This model was applied to data from phase II/III trials ... | 18,852,492 |
Morphogenetic behavior of tropical marine yeast Yarrowia lipolytica in response to hydrophobic substrates. | The morphogenetic behavior of a tropical marine Yarrowia lipolytica strain on hydrophobic substrates was studied. Media containing coconut oil or palm kernel oil (rich in lauric and myristic acids) prepared in distilled water or seawater at a neutral pH supported 95% of the cells to undergo a transition from the yeast ... | 18,852,507 |
Beneficial effects of fluorescent pseudomonads on seed germination, growth promotion, and suppression of charcoal rot in groundnut (Arachis hypogea L.). | Rhizobacteria are used as inoculants to enhance crop yield and for biological control of fungal pathogens. Fluorescent pseudomonads isolated from the rhizosphere of groundnut showed suppression of the phytopathogen Macrophomina phaseolina that causes charcoal rot of groundnut, an economically important agroproduct. Two... | 18,852,515 |
Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. | There are no data showing whether or not age-related declines in physical function are related to in vitro properties of human skeletal muscle. The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults. ... | 18,852,542 |
Rehabilitative outcome in supratentorial and infratentorial stroke: the role of motor deficits. | There are few studies on the functional outcome of patients with supratentorial (STS) and infratentorial stroke (ITS). They lead to conflicting conclusions and do not define the role of motor deficits on functional recovery of STS and ITS patients. We wished to investigate this. The study was carried out on 90 consecut... | 18,852,543 |
Vitamin D supplementation has no major effect on pain or pain behavior in bedridden geriatric patients with advanced dementia. | In a few, earlier, uncontrolled trials, alleviation of chronic pain has been documented by vitamin D supplementation. This randomized double-blind placebo controlled trial addressed the association between pain and vitamin D deficiency and the effects of vitamin D supplementation on pain in institutionalized aged patie... | 18,852,544 |
Mental health economics, health service provision, and the practice of geriatric psychiatry. | Economic evaluation is becoming more and more important as a means to assist policy makers in choosing the best intervention or treatment against a pervasive scarcity of resources relative to the demands. Health service provision and the practice of geriatric psychiatry are closely associated with costs and outcomes of... | 18,852,560 |
Cultural and social history of psychiatry. | The purpose of this review is to highlight recent English language literature in the cultural and social history of psychiatry. It considers publications from 2007 and early 2008, as well as a few important older works that have not yet been reviewed in this journal. Cultural and social historians of psychiatry are inc... | 18,852,566 |
Cardiomyopathy induced by adenosine-insensitive atrial tachycardia. | Tachycardia-induced cardiomyopathy may be provoked by several arrhythmias; it may reverse following stable restoration of sinus rhythm. We report the case of a 33-year-old man who was diagnosed to have a dilated cardiomyopathy. Over a few months, the cardiomyopathy reversed. Subsequently, atrial tachycardia, associated... | 18,852,591 |
An uncommon case of right-sided throat pain and swallow syncope. | A 63-year-old man presented with recurrent syncopal attacks associated with swallowing and right-sided throat pain. Immediately after admission, he presented a 16-s asystolia. The patient's clinical history was unremarkable except for previous postimplant periodontitis. Several episodes of severe bradycardia and sinus ... | 18,852,592 |
The decline of cardiac auscultation: 'the ball of the match point is poised on the net'. | A brief review of the history of cardiac auscultation confirms its decline. The intervention of healthcare institutions may avoid loss of medical culture and increased costs by adequate training of medical staff. | 18,852,598 |
Implicit and explicit stigma of mental illness: links to clinical care. | This study examined implicit and explicit measures of bias toward mental illness among people with different levels of mental health training, and investigated the influence of stigma on clinically-relevant decision-making. Participants (N = 1539) comprised of (1) mental health professionals and clinical graduate stude... | 18,852,619 |
Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease. | Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with obesity, and is now the most common liver disease in the United States. Cytokeratin 18 (CK18) is an intracellular protein released into the blood by both necrosis and apoptosis of hepatocytes. Levels of CK18 have not been reported previ... | 18,852,641 |
ABO incompatible living renal transplantation with a steroid sparing protocol. | ABO incompatible (ABOi) live-donor renal transplantation is a successful and accepted form of treatment for patients with renal failure. Although there is significant controversy as to how antiblood group antibodies should be removed and their resynthesis prevented, subsequent immunosuppressive regimes have all involve... | 18,852,653 |
Collagenase penetrates human pancreatic islets following standard intraductal administration. | : To optimize human islet isolation, it is important to improve our understanding of the collagenase digestion phase. Previous studies of collagenase action were mostly concerned with optimizing its composition, but the delivery and distribution of collagenase at the islet-exocrine interface is likely to be important f... | 18,852,654 |
Epithelioid hemangioma of bone revisited: a study of 50 cases. | The clinical and pathologic features of 50 epithelioid hemangiomas of bone are analyzed. There were 29 males and 21 females who ranged in age from 10 to 75 (mean 35) years. The tumors arose in long tubular bones (40%), short tubular bones of the distal lower extremity (18%), flat bones (18%), vertebrae (16%), and small... | 18,852,673 |
Structural remodeling in atrial fibrillation. | Atrial fibrillation occurs and maintains itself in the context of a morphologically and functionally altered atrial substrate that can be induced by stressors such as underlying diseases (cardiac or noncardiac) or aging. The resultant structural remodeling is a slow process that progressively affects myocytes and the m... | 18,852,714 |
Duloxetine and pregabalin: safe and effective for the long-term treatment of fibromyalgia? | This Practice Point commentary discusses the first two trials of long-term drug treatment in fibromyalgia. In Russell et al.'s study, 33% of patients receiving 6-month treatment with 60 mg/day duloxetine responded to therapy; the number needed to treat was seven. In the three treatment arms, 15% (60 mg/day duloxetine),... | 18,852,724 |
Highly nonlinear silica suspended core fibers. | Suspended-core fibers are systematically studied. We show that confinement loss in suspended-core fibers can be effectively reduced by an increase of air-cladding width for even sub-micron core diameters and, therefore, provides a considerable simpler solution than equivalent photonic crystal fibers with a large number... | 18,852,748 |
Rapid and inexpensive fabrication of terahertz electromagnetic bandgap structures. | Modern rapid prototyping technologies are now capable of build resolutions that allow direct fabrication of photonic structures in the GHz and THz frequency regimes. To demonstrate this, we have fabricated several structures with 3D electromagnetic bandgaps in the 100-400 GHz range. Characterization of these structures... | 18,852,750 |
Time fluctuations of the phase modulation in a liquid crystal on silicon display: characterization and effects in diffractive optics. | In this paper we provide evidence of the temporal fluctuations of the phase modulation property of a liquid crystal on silicon (LCoS) display, and we analyze its effect when the device is used for displaying a diffractive optical element. We use a commercial twisted nematic LCoS display configured to produce a phase-on... | 18,852,780 |
Fabrication of thermally stable and cost-effective polymeric waveguide for optical printed-circuit board. | A thermally stable polymeric optical waveguide has been fabricated using ultraviolet (UV)-curable epoxy resins for the core and clad materials. A simple and cost-effective fabrication method that uses reusable polydimethylsiloxane (PDMS) masters has been developed. The 12-channel under-clad layer of the UV-cured epoxy ... | 18,852,788 |
Unusual entanglement transformation properties of the quantum radiation through one-dimensional random system containing left-handed-materials. | The quantum radiation through the multilayer structures containing the left-handed materials is investigated based on the Green-function approach to the quantization of the phenomenological Maxwell theory. Emphasis is placed on the effect of randomness on the generation and transmission of entangled-states. It is shown... | 18,852,803 |
Fast and simple characterization of a photon pair source. | We present an exact model of the detection statistics of a probabilistic source of photon pairs from which a fast, simple and precise method to measure the source's brightness and photon channel transmissions is demonstrated. We measure such properties for a source based on spontaneous parametric downconversion in a pe... | 18,852,816 |
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