title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
S1P receptor signalling and RGS proteins; expression and function in vascular smooth muscle cells and transfected CHO cells. | Sphingosine-1-phosphate (S1P) signalling via G protein-coupled receptors is important for the regulation of cell function and differentiation. Specific Regulators of G protein Signalling (RGS) proteins modulate the function of these receptors in many cell types including vascular smooth muscle cells (VSMCs). Therefore,... | 18,854,184 |
Post-natal exposure to corticosterone affects standard metabolic rate in the zebra finch (Taeniopygia guttata). | Post-natal stress has been shown to have important short and long term effects on many adult traits in birds. During stress, metabolic alterations often result in the mobilization of energy away from energy-sensitive functions such as growth, which could have significant implications for developing animals. However, li... | 18,854,187 |
Behavioral recovery from acute hypoxia is reliant on leptin. | Individuals affected by hypoxia experience a variety of immune-associated sickness symptoms including malaise, fatigue, lethargy and loss of interest in the physical and social environment. Recently, we demonstrated that the interleukin (IL)-1beta arm of the neuroimmune system was critical to the sickness symptoms caus... | 18,854,211 |
Calcium-dependent activation of mitochondrial metabolism in mammalian cells. | Endogenous fluorophores provide a simple, but elegant means to investigate the relationship between agonist-evoked Ca2+ signals and the activation of mitochondrial metabolism. In this article, we discuss the methods and strategies to measure cellular pyridine nucleotide and flavoprotein fluorescence alone or in combina... | 18,854,213 |
Silver nanoparticles as a new generation of antimicrobials. | Silver has been in use since time immemorial in the form of metallic silver, silver nitrate, silver sulfadiazine for the treatment of burns, wounds and several bacterial infections. But due to the emergence of several antibiotics the use of these silver compounds has been declined remarkably. Nanotechnology is gaining ... | 18,854,209 |
Identification and expression of a factor of the DM family in the oyster Crassostrea gigas. | The Pacific oyster Crassostrea gigas is a successive not systematic protandric hermaphrodite. Searching for an ortholog to Dmrt1, a conserved sex determinism factor, we have identified the first complete cDNA of a DM factor in Lophotrochozoa which we have called Cg-DMl (Crassostrea gigas DMRT-like). It is 359aa long, w... | 18,854,223 |
Taming data. | A challenge in systems-level investigations of the immune response is the principled integration of disparate data sets for constructing predictive models. InnateDB (Lynn et al., 2008; http://www.innatedb.ca), a publicly available, manually curated database of experimentally verified molecular interactions and pathways... | 18,854,235 |
An inhibitor of gram-negative bacterial virulence protein secretion. | Bacterial virulence mechanisms are attractive targets for antibiotic development because they are required for the pathogenesis of numerous global infectious disease agents. The bacterial secretion systems used to assemble the surface structures that promote adherence and deliver protein virulence effectors to host cel... | 18,854,237 |
Face recognition using spatially constrained earth mover's distance. | Face recognition is a challenging problem, especially when the face images are not strictly aligned (e.g., images can be captured from different viewpoints or the faces may not be accurately cropped by a human or automatic algorithm). In this correspondence, we investigate face recognition under the scenarios with pote... | 18,854,252 |
Visual attention on the sphere. | Human visual system makes an extensive use of visual attention in order to select the most relevant information and speed-up the vision process. Inspired by visual attention, several computer models have been developed and many computer vision applications rely today on such models. However, the actual algorithms are n... | 18,854,253 |
Lossless compression of color sequences using optimal linear prediction theory. | In this paper, we present a novel technique that uses the optimal linear prediction theory to exploit all the existing redundancies in a color video sequence for lossless compression purposes. The main idea is to introduce the spatial, the spectral, and the temporal correlations in the autocorrelation matrix estimate. ... | 18,854,256 |
Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies. | Overproduction of plasma cell-derived monoclonal free kappa or lambda immunoglobulin light chains (FLCs) is a hallmark of multiple myeloma, AL amyloidosis, and light chain deposition disease. Because these components serve as unique cellular and serologic biomarkers, their detection and quantitation has diagnostic, the... | 18,854,262 |
A multi-institutional survey of critical diagnoses (critical values) in surgical pathology and cytology. | Critical values (CVs) are well established in clinical pathology, and an analogous concept has recently been suggested in anatomic pathology, with the terminology of critical values, or, alternatively, critical diagnoses (CDs). To better identify anatomic pathology CVs, a survey was sent to 225 members of the Associati... | 18,854,265 |
Comparison of Russell viper venom-based and activated partial thromboplastin time-based screening assays for resistance to activated protein C. | Thrombotic disease is a significant cause of mortality and morbidity, with an estimated lifetime risk of greater than 10% in Western populations. One of the most common hereditary thrombophilias is the factor V Leiden mutation, which is identified with a screening assay for activated protein C (APC) resistance and conf... | 18,854,273 |
Value of [18F]fluorodeoxyglucose positron emission tomography in the management of follicular lymphoma: the end of a dilemma? | [18F]Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a powerful tool for the imaging of various lymphomas. Despite its high FDG avidity, there is little data on PET in follicular lymphoma (FL). In this work, we present findings concerning PET at staging and posttreatment evaluation in FL. A total of 181 ... | 18,854,283 |
Increased serum tumor markers (CA125 and CA15.3) in primary plasma cell leukemia: a case report and review of the literature. | 73-year-old woman complaining of bone pain and weight loss was suspected to have a malignant disease, and extensive laboratory investigations were carried out. She was diagnosed with multiple myeloma; however, because of the finding of extremely high serum levels of CA125 and CA15.3 and focal liver lesions, a concomita... | 18,854,288 |
Grunting for worms: seismic vibrations cause Diplocardia earthworms to emerge from the soil. | Harvesting earthworms by a practice called 'worm grunting' is a widespread and profitable business in the southeastern USA. Although a variety of techniques are used, most involve rhythmically scraping a wooden stake driven into the ground, with a flat metal object. A common assumption is that vibrations cause the worm... | 18,854,292 |
Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis. | Reactive oxygen species (ROS) have been implicated in vascular smooth muscle cell (VSMC) apoptosis, a hallmark of advanced atherosclerotic lesions. Transient oxidation and inactivation of protein-tyrosine phosphatases play a critical role in cellular response to ROS production. However, the function of leukocyte antige... | 18,854,310 |
Screening for deep vein thrombosis in asymptomatic high-risk patients: a comparison between digital photoplethysmography and venous ultrasonography. | To determine the role of digital photoplethysmography in screening asymptomatic patients who are susceptible for developing deep vein thrombosis. Three hundred and thirty-seven limbs in 169 patients who were high risk for development of deep vein thrombosis were assessed by ultrasonography digital photoplethysmography ... | 18,854,340 |
The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications. | Cornelia de Lange Syndrome (CdLS) is a rare congenital malformation disorder. About half of the patients with CdLS carry mutations in the NIPBL gene encoding the NIPBL protein, a subunit of the Cohesin loading complex. Recent studies show association of Cohesin with chromatin-remodeling complexes, either by establishin... | 18,854,353 |
Translation affects YoeB and MazF messenger RNA interferase activities by different mechanisms. | Prokaryotic toxin-antitoxin loci encode mRNA cleaving enzymes that inhibit translation. Two types are known: those that cleave mRNA codons at the ribosomal A site and those that cleave any RNA site specifically. RelE of Escherichia coli cleaves mRNA at the ribosomal A site in vivo and in vitro but does not cleave pure ... | 18,854,355 |
Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition. | Predictive models of complex drug-drug interactions between multiple inhibitors and their metabolites have not been evaluated. The purpose of this study was to evaluate an interaction model for cytochrome P450 3A4 (CYP3A4) that incorporated the simultaneous reversible and irreversible inhibition by multiple inhibitors.... | 18,854,379 |
Complement abnormalities in acquired lipodystrophy revisited. | Lipodystrophy is a heterogeneous condition characterized by an inherited or acquired deficiency in the number of adipocytes required for the storage of energy as triglycerides. Acquired lipodystrophy is frequently associated with other autoimmune disorders. One well-studied form is characterized by the selective loss o... | 18,854,390 |
Acute moderate elevation of TNF-alpha does not affect systemic and skeletal muscle protein turnover in healthy humans. | Skeletal muscle wasting has been associated with elevations in circulating inflammatory cytokines, in particular TNF-alpha. In this study, we investigated whether TNF-alpha affects human systemic and skeletal muscle protein turnover via a 4-h recombinant human (rh) TNF-alpha infusion. We hypothesize that TNF-alpha incr... | 18,854,397 |
Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women. | Recent studies reported that retinol-binding protein 4 (RBP4) has a causal role in insulin resistance and suggested that its circulating levels may predict cardiovascular disease. However, the latter assumption has not yet been tested. We assessed the value of RBP4 measurement in the prediction of incident coronary art... | 18,854,400 |
Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. | Decidual vascular development is important for implantation. This study analysed decidual vascular adaptation to implantation in correlation with miscarriage in decidual secretory endometrium (DSE), decidua parietalis (DP) and decidua basalis (DB) of miscarriage patients and matched controls. Decidua was obtained durin... | 18,854,409 |
Measuring the effectiveness of protected area networks in reducing deforestation. | Global efforts to reduce tropical deforestation rely heavily on the establishment of protected areas. Measuring the effectiveness of these areas is difficult because the amount of deforestation that would have occurred in the absence of legal protection cannot be directly observed. Conventional methods of evaluating th... | 18,854,414 |
Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages. | Adipose differentiation-related protein (ADRP) is highly expressed in macrophages and human atherosclerotic lesions. We demonstrated that Toll-like receptor (TLR) 4-mediated signals, which are involved in atherosclerosis formation, enhanced the expression of ADRP in macrophages. Lipopolysaccharide (LPS) enhanced the AD... | 18,854,426 |
Comparison of eye lens dose on neuroimaging protocols between 16- and 64-section multidetector CT: achieving the lowest possible dose. | To our knowledge, there has been no study that compares the radiation dose delivered to the eye lens by 16- and 64-section multidetector CT (MDCT) for standard clinical neuroimaging protocols. Our aim was to assess radiation-dose differences between 16- and 64-section MDCT from the same manufacturer, by using near-iden... | 18,854,441 |
Occipital intradiploic CSF pseudocyst: an unusual complication of a ventriculoperitoneal shunt malfunction. | We report a rare and unique complication of ventriculoperitoneal (VP) shunt malfunction. A progressively expansile, CSF-containing occipital intradiploic cyst developed in a 15-year-old boy at the site of cystoperitoneal shunt draining a Dandy-Walker cyst; the shunt was placed when the boy was 4 years old. A proposed p... | 18,854,442 |
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates. | beta-Site amyloid precursor protein (APP)-cleaving enzyme (BACE) 1 cleavage of amyloid precursor protein is an essential step in the generation of the potentially neurotoxic and amyloidogenic A beta 42 peptides in Alzheimer's disease. Although previous mouse studies have shown brain A beta lowering after BACE1 inhibiti... | 18,854,490 |
Seasonal and regional short-term effects of fine particles on hospital admissions in 202 US counties, 1999-2005. | The authors investigated whether short-term effects of fine particulate matter with an aerodynamic diameter < or =2.5 microm (PM(2.5)) on risk of cardiovascular and respiratory hospitalizations among the elderly varied by region and season in 202 US counties for 1999-2005. They fit 3 types of time-series models to p... | 18,854,492 |
The impact of a large reduction in the price of alcohol on area differences in interpersonal violence: a natural experiment based on aggregate data. | This paper examines the effect of a drastic reduction in the price of alcohol that occurred in Finland in 2004 on interpersonal violence in the Helsinki Metropolitan Area, and how these changes varied at the small-area level. This study comprised 86 administrative tracts from the Helsinki Metropolitan Area. Data pertai... | 18,854,505 |
Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology. | Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal. For decades the diagnosis was confirmed only with pyridoxine treatment withdrawal trial. Recently described biochemical and molecular pathology improved the diagnostic... | 18,854,520 |
Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring. | Micronuclei (MN) frequencies in peripheral blood lymphocytes have been used worldwide as a biomarker of chromosomal damage for genotoxicity testing and biomonitoring studies. Automation of MN analysis would provide faster and more reliable results with minimizing subjective MN identification. We developed an automated ... | 18,854,579 |
Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus. | Genetic analysis of parasitic nematodes has been a neglected area of research and the basic genetics of this important group of pathogens are poorly understood. Haemonchus contortus is one of the most economically significant livestock parasites worldwide and is a key experimental model for the strongylid nematode grou... | 18,854,587 |
The effect of third harmonic transmit phasing on contrast agent responses for CTR improvement. | Harmonic detection of ultrasonic contrast agents provides a limited contrast-to-tissue ratio (CTR) mainly because of background tissue harmonic signals. To suppress tissue harmonic amplitude, the method of third harmonic (3f(0)) transmit phasing can be utilized by phasing an additional 3f(0) transmit signal to achieve ... | 18,854,607 |
Characterization of a scintillating GEM detector with low energy x-rays. | A two-dimensional position-sensitive dosimetry system based on a scintillating gas detector is being developed with the aim of using it for pre-treatment verification of dose distributions in charged particle therapy. The dosimetry system consists of a chamber filled with an Ar/CF(4) scintillating gas mixture, inside w... | 18,854,612 |
Simple analytical expressions for the dose of point photon sources in homogeneous media. | The contributions to the dose of a point photon source in homogeneous media due to primary and first, second, ..., nth scattered photons are investigated. Assuming a simple statistical model, an analytical form comes out for each of these contributions. It includes a polynomial and a single exponential and depends on t... | 18,854,613 |
Clinical utility of evaluating intracranial artery stenosis and silent brain infarction to predict the presence of subclinical coronary artery disease in ischemic stroke patients. | We have recently reported the prevalence of subclinical cardiovascular diseases and the association between the presence of subclinical coronary artery disease (CAD) and vascular risk factors in ischemic stroke patients. The relationship between the presence of subclinical CAD and elements of brain ischemia including i... | 18,854,628 |
Survey on the handling of chronic obstructive pulmonary disease by annual health check in Japan. | Since mild COPD can be detected in the annual health check by lung function tests, we conducted a questionnaire survey on how such examinations are used to assess chronic obstructive pulmonary disease (COPD). We mailed questionnaires to 633 facilities performing comprehensive medical check-up from June to July 2005 and... | 18,854,630 |
Endoscopic removal of an accidentally swallowed toothbrush. | A rare case is reported with a large foreign body in the upper gastrointestinal tract. A 19-year-old girl accidentally swallowed her toothbrush which was successfully removed via endoscopy using a polypectomy snare under topical pharyngeal anesthesia. The extracted toothbrush was 20 cm long, and it had the characterist... | 18,854,631 |
Left ventricular oozing rupture following acute myocardial infarction. | We describe the case of an 85-year-old woman in whom pericardiocentesis, prolonged bed rest and blood pressure control were performed without surgery to successfully treat an oozing-type myocardial rupture due to myocardial infarction. | 18,854,633 |
Palliative radiotherapy of retrobulbar orbit metastases due to breast cancer. | In breast cancer, the occurrence of retrobulbar metastases of the orbit is rare compared to intraocular metastases. The clinical symptoms are quite different. Impairment of vision, exophthalmus, double vision, vertigo, and pain reduce patients' quality of life. The benefit of palliative irradiation of the orbit was res... | 18,854,652 |
Hypertension and the eye. | This article reviews the findings of systemic hypertension in the eye and how these changes represent disease in the eye itself, as well as the predictive value of fundoscopic findings in relation to overall health. Systemic hypertension is associated with observable changes in the retinal microvasculature, including r... | 18,854,694 |
The eye and thyroid disease. | The pathophysiology and optimal management of thyroid eye disease (TED) have not yet been elucidated. Recent studies have increased our knowledge of the disease process and different diagnostic and therapeutic options. This review highlights the recent progress in TED research and identifies areas requiring further adv... | 18,854,695 |
Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease. | The Women's Health Initiative randomized trial found greater coronary heart disease (CHD) risk in women assigned to estrogen/progestin therapy than in those assigned to placebo. Observational studies had previously suggested reduced CHD risk in hormone users. Using data from the observational Nurses' Health Study, we e... | 18,854,702 |
Emergence of Asiatic Vibrio diseases in South America in phase with El Niño. | The seventh pandemic of Vibrio cholerae unexpectedly reached the coast of Peru in 1991, causing an explosive emergence of infections throughout the American continents. The origin and routes of dissemination are as yet unknown. A new Vibrio epidemic arose in 1997 in South America (northern Chile) when the pandemic clon... | 18,854,707 |
Self-reported and measured sleep duration: how similar are they? | Recent epidemiologic studies have found that self-reported duration of sleep is associated with obesity, diabetes, hypertension, and mortality. The extent to which self reports of sleep duration are similar to objective measures and whether individual characteristics influence the degree of similarity are not known. El... | 18,854,708 |
Assessing the efficacy of 2 years of maintenance treatment with venlafaxine extended release 75-225 mg/day in patients with recurrent major depression: a secondary analysis of data from the PREVENT study. | The objective of this study was to evaluate the long-term efficacy of venlafaxine extended release (ER) < or =225 mg/day in patients with recurrent major depressive disorder (MDD). In this double-blind trial, outpatients with recurrent MDD (N=1096) were randomized to 10 weeks of acute-phase treatment with venlafaxin... | 18,854,724 |
Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography. | To understand better the influence of retinal blood vessels (BVs) on the interindividual variation in the retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). RNFL thickness profiles were measured by OCT in 16 control individuals and 16 patients. The patients had advanced glaucom... | 18,854,727 |
Adult onset buphthalmos in a patient with marfan syndrome. | To report a Marfan patient with an adult onset of buphthalmos. Observational case report. Review of clinical, photographic, and ultrasound data of a 20-year-old Marfan patient who underwent an intraocular lens implantation complicated by late retinal detachment, chronic hyphema, and elevated intraocular pressure (IOP).... | 18,854,734 |
Increased Long-term measurement variability with scanning laser polarimetry employing enhanced corneal compensation: an early sign of glaucoma progression. | To investigate whether the intervisit standard deviation (ISD) of various scanning laser polarimetry parameters is increased, in progressing glaucoma. GDx-variable corneal compensation (VCC) and GDx-enhanced corneal compensation (ECC) measurements, and Octopus G2 visual field tests, were performed at 6-month intervals ... | 18,854,736 |
Long-term comparison of primary trabeculectomy with 5-fluorouracil versus mitomycin C in West Africa. | To compare the long-term efficacy and safety of intraoperative 5-fluorouracil (5-FU) versus mitomycin-C (MMC) used adjunctively with primary trabeculectomy in a Black West African population. Retrospective comparative study supplemented with cross-sectional follow-up data. Review of 68 eyes of 68 Black West African sub... | 18,854,737 |
The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes. | To compare the effects of two antihypertensive treatment strategies for the prevention of coronary heart disease and other cardiovascular events in the large subpopulation (n=5137) with diabetes mellitus in the blood pressure-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial. Patients had either untreated h... | 18,854,748 |
Anthropometric and dietary determinants of blood pressure in over 7000 Mediterranean women: the European Prospective Investigation into Cancer and Nutrition-Florence cohort. | Anthropometric characteristics and dietary habits are widely recognized to influence blood pressure. We evaluated their role in a large series of Mediterranean adult women. In Florence, in the European Prospective Investigation into Cancer and Nutrition, we recruited 10 083 women, aged 35-64 years. Detailed information... | 18,854,749 |
Interindividual variation in serum sodium and longitudinal blood pressure tracking in the Framingham Heart Study. | Recent cross-sectional studies have suggested that higher serum sodium levels may be a marker of elevated blood pressure. It is unclear whether serum sodium levels are related to the risk of developing hypertension in the community. We investigated the association of serum sodium with longitudinal blood pressure tracki... | 18,854,750 |
Nonalcoholic fatty liver disease, adiponectin and insulin resistance in dipper and nondipper essential hypertensive patients. | The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial, and the presence of insulin resistance is recognized as the pathophysiological hallmark of this condition. Arterial hypertension is referred as an insulin-resistant state, and insulin resistance may substantially contribute to the cardiovas... | 18,854,760 |
Switch of immunosuppression from cyclosporine A to everolimus: impact on pulse wave velocity in stable de-novo renal allograft recipients. | Cardiovascular mortality is extraordinarily high in renal allograft recipients and accounts for almost half of all allograft losses. Whereas the immunosuppression with calcineurin inhibitors is associated with an increased cardiovascular risk, beneficial effects of mammalian target of rapamycin inhibitors on the vascul... | 18,854,763 |
Oxidative stress after uninephrectomy alters heart morphology in the apolipoprotein E -/- mouse. | Even minor reduction in glomerular filtration rate accelerates atherogenesis and increases cardiovascular risk. The current study on the apolipoprotein E -/- mouse was designed to investigate whether nephron reduction by uninephrectomy causes cardiac remodeling and whether this is prevented by antioxidative treatment. ... | 18,854,764 |
Percutaneous versus surgical bedside tracheostomy in the intensive care unit: a cohort study. | To compare the outcomes, as well as the short and long term complications, of percutaneous dilational tracheostomy (PDT) and surgical tracheostomy (ST) at the bedside. From 2003 to 2005, 367 consecutive patients underwent percutaneous tracheostomy in two general ICUs of a community hospital. Short and long term complic... | 18,854,794 |
Dilatative percutaneous tracheostomy during double antiplatelet therapy: two consecutive cases. | This article reports two cases of dilatative percutaneous tracheostomy performed on patients treated with double antiplatelet therapy. Both patients had cardiac arrest following myocardial infarction. After primary angioplasty with stent placement, a double antiplatelet therapy was started. Due to poor neurological out... | 18,854,797 |
[Anticoagulant prophylaxis in women affected by thrombophilia and previous obstetric complications]. | Pregnancy is a condition of excessive clotting due to a decrease of some coagulation factors and a reduction of anticoagulant proteins, such as protein S. It is known that the causes of congenital or acquired thrombophilia may be associated with an increased risk of venous thromboembolism during pregnancy and/or obstet... | 18,854,809 |
C-Fos expression is a molecular predictor of progression and survival in epithelial ovarian carcinoma. | Members of the Fos protein family dimerise with Jun proteins to form the AP-1 transcription factor complex. They have a central function in proliferation and differentiation of normal tissue as well as in oncogenic transformation and tumour progression. We analysed the expression of c-Fos, FosB, Fra-1 and Fra-2 to inve... | 18,854,825 |
Inhibition of HIF-1alpha by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo. | In a previous study, we showed that a novel anticancer drug, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (TAS106, ECyd) increased the antitumour efficacy of X-irradiation. However, its effects on hypoxic cells in tumours remain unclarified. Here, we show that TAS106 enhances the induction of apoptosis in X-irrad... | 18,854,835 |
The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer. | Vimentin, nuclear factor-kappaB (NF-kappaB) p105, fascin, E-cadherin, TGF-beta, Par6 and atypical PKC are molecular markers that play an important role in cell differentiation. Herein, we investigate their prognostic impact in primary non-small-cell carcinoma (NSCLC). Tumour tissue samples from 335 resected patients wi... | 18,854,838 |
The first solid composed of [As4V16O42(H2O)] clusters. | A new polyoxovanadate [Zn2(dien)3][[Zn(dien)]2As4V16O42(H2O)] x 3H2O (1, dien = diethylenetriamine) has been hydrothermally synthesized and structurally characterized by EA, IR, TGA, magnetic measurement and single crystal X-ray diffraction. X-Ray diffraction analyses reveal that 1 exhibits the first [As4V16O42(H2O)]-c... | 18,854,895 |
The structure of Fe(III) ions in strongly alkaline aqueous solutions from EXAFS and Mössbauer spectroscopy. | To establish the structure of ferric ions in strongly alkaline (pH > 13) environments, aqueous NaOH solutions supersaturated with respect to Fe(III) and the solid ferric-hydroxo complex salts precipitating from them have been characterized with a variety of experimental techniques. From UV measurements, in solutions... | 18,854,898 |
Syntheses and structures of half-sandwich iridium(III) and rhodium(III) complexes with organochalcogen (S, Se) ligands bearing N-methylimidazole and their use as catalysts for norbornene polymerization. | The organochalcogen ligands derived from 3-methyl-imidazole-2-thione/selone groups, Mbit, Mbis, Ebit and Ebis [Mbit = 1,1'-methylenebis(3-methyl-imidazole-2-thione); Mbis = 1,1'-methylenebis(3-methyl-imidazole-2-selone), Ebit = 1,1'-(1,2-ethanediyl)bis(3-methyl-imidazole-2-thione), Ebis = 1,1'-(1,2-ethanediyl)bis(3-met... | 18,854,899 |
Composition, distribution and characterization of polybrominated diphenyl ethers (PBDEs) in the soil in Taiyuan, China. | A total of 21 surface soil samples covering the whole territory of Taiyuan city were collected for analysis the 39 polybrominated diphenyl ethers (PBDEs). The total PBDEs concentration ranged from 0.016 to 211.416 ng g(-1) in urban soils and 5.961 to 144.162 ng g(-1) in industrial plant soils. PBDE homologues analysis ... | 18,854,905 |
Early and midterm outcomes of open stent-graft treatment for distal aortic arch aneurysm. | The aim of this study was to investigate early and late outcomes for open stent-graft treatment, which was introduced as a less-invasive technique for thoracic aortic aneurysm of the distal arch, and to clarify the validity of and indications for this treatment. We retrospectively investigated 38 patients with thoracic... | 18,854,925 |
Mitral valve replacement for extensive calcification: half and half technique. | A 50-year-old woman who had been undergoing hemodialysis for 18 years underwent mitral valve replacement because of mitral valve stenosis. Her mitral valve leaflet and annulus were highly calcified, and it was impossible to remove the posterior leaflet from the ventricular wall. At the time of surgery, noneverted horiz... | 18,854,933 |
Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. | Bone marrow mesenchymal stem cells (MSCs) are multipotent cells, which among other cell lineages, give rise to adipocytes and osteoblasts. Within the bone marrow, the differentiation of MSCs into adipocytes or osteoblasts is competitively balanced; mechanisms that promote one cell fate actively suppress mechanisms that... | 18,854,943 |
Bile acid alone, or in combination with acid, induces CDX2 expression through activation of the epidermal growth factor receptor (EGFR). | Bile acids and acid are implicated in the development of Barrett's esophagus. Evidence suggests that Barrett's esophagus intestinal metaplasia may occur via induction of caudal homeobox gene 2 (CDX2). We hypothesized that induction of CDX2 by bile acids may be due to ligand-dependent transactivation of epidermal growth... | 18,854,960 |
[Single base polymorphisms and erectile dysfunction]. | The risk for erectile dysfunction is closely linked to cardiovascular morbidities such as coronary heart disease, arterial hypertension, hypercholesterolemia, and diabetes. Molecular analysis revealed an association between the genotypes in single base polymorphisms and the risk for these cardiovascular morbidities. In... | 18,854,967 |
Specialist team retrieval of head injured patients: fact, fiction, or formula? | This feasibility study aimed to determine the maximum theoretical distance the Edinburgh Paediatric Retrieval Team (EPRT) could travel to retrieve head injured children without additional delay in reaching definitive care. A prospective audit was conducted over 2 years to determine the current practice for paediatric h... | 18,854,974 |
Effects of sibutramine and rimonabant in rats trained to discriminate between 22- and 2-h food deprivation. | The objective of the study was to evaluate whether sibutramine and rimonabant, drugs that decrease food intake in human and non-human animals, affect the discriminative stimulus effects associated with acute food deprivation ("hunger"). Rats were trained to discriminate between 22- and 2-h food deprivation in a two-lev... | 18,854,986 |
[The spectrum of microbiological agents causing pulmonary MALT-type lymphomas. A 16S rRNA-based analysis of microbial diversity]. | For several anatomical localisations of extranodal marginal zone B-cell lymphoma of MALT type (eMZBCL), an association with chronic inflammation caused by microbiological agents (e.g. Helicobacter pylori in the stomach) has been described. In the lung, a link between lymphomagenesis and a defined causative organism is ... | 18,854,998 |
Analysis of CYP7B1 in non-consanguineous cases of hereditary spastic paraplegia. | Hereditary spastic paraplegia (HSP) is a neurodegenerative condition defined clinically by lower limb spasticity and weakness. Homozygous mutations in CYP7B1 have been identified in several consanguineous families that represented HSP type 5 (SPG5), one of the many genetic forms of the disease. We used direct sequencin... | 18,855,023 |
Toxoplasma gondii antibody profile in HIV-infected pregnant women and the risk of congenital toxoplasmosis. | The purpose of this study was to investigate the antibodies to Toxoplasma gondii in human immunodeficiency virus (HIV)-infected pregnant women and to determine the association between serological profile and the risk of congenital toxoplasmosis. The study, conducted in a public maternity ward from May 2002 to April 200... | 18,855,029 |
Feasibility of measuring trabecular bone structure of the proximal femur using 64-slice multidetector computed tomography in a clinical setting. | We studied the feasibility of cancellous bone structure assessment of the proximal femur using multidetector computed tomography (MDCT) in an simulated in vivo experimental model. The proximal femur of 15 intact human cadavers was examined using 64-row MDCT using a thin-section protocol with an in-plane spatial resolut... | 18,855,036 |
Is a circular polypropylene mesh appropriate for application at the esophageal hiatus? Results from an experimental study in a porcine model. | Mesh reinforcement in hiatal hernia surgery is debated. Randomized controlled trials have shown that recurrences may be reduced, but there is also the fear of mesh-related complications. Experimental studies on the characteristics of specific mesh types with regard to the risk of such complications are rare. The curren... | 18,855,052 |
Ergonomics, user comfort, and performance in standard and robot-assisted laparoscopic surgery. | Robot-assisted surgical systems have been introduced to improve the outcome of minimally invasive surgery. These systems also have the potential to improve ergonomics for the surgeon during endoscopic surgery. This study aimed to compare the user's mental and physical comfort in performing standard laparoscopic and rob... | 18,855,053 |
Natural orifice translumenal endoscopic drainage for pancreatic abscesses. | Few series describe endoscopic drainage of pancreatic abscesses. Abscesses are complications of pancreatitis, presenting with sepsis, peritonitis, or both. This report describes the feasibility and efficacy of natural orifice translumenal endoscopic surgery for pancreatic abscesses. This study reviewed 35 consecutively... | 18,855,067 |
The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. | Obesity has emerged as one of the most serious public health concerns in the twenty-first century. the fat mass and obesity associated gene (FTO) has been found to contribute to the risk of obesity in humans. Our aims in this study were to investigate the association of rs9939609 single nucleotide polymorphism (SNP) of... | 18,855,084 |
Extremely small-magnitude accelerations enhance bone regeneration: a preliminary study. | High-frequency, low-magnitude accelerations can be anabolic and anticatabolic to bone. We tested the hypothesis that application of these mechanical signals can accelerate bone regeneration in scaffolded and nonscaffolded calvarial defects. The cranium of experimental rats (n = 8) in which the 5-mm bilateral defects ei... | 18,855,088 |
State estimation in the cerebellum. | An exciting hypothesis about the cerebellum is that its role is one of state estimation--a process that combines efferent copies of motor commands with afferent sensory signals to produce a representation of the current status of the peripheral motor system. Sensory inputs alone cannot provide a perfect state signal be... | 18,855,092 |
Recombinant bactericidal permeability increasing protein (rBPI21) inhibits surgery-induced tumour growth in a murine model of metastatic disease. | Endotoxin (LPS), a cell wall constituent of gram-negative bacteria, is a potent inflammatory stimulus. We demonstrated that laparotomy increases primary tumour growth and experimental lung metastases, implicating endotoxin as a causative factor. We hypothesised that the anti-endotoxin agent, rBPI(21) would block surger... | 18,855,097 |
Astrobiological phase transition: towards resolution of Fermi's paradox. | Can astrophysics explain Fermi's paradox or the "Great Silence" problem? If available, such explanation would be advantageous over most of those suggested in literature which rely on unverifiable cultural and/or sociological assumptions. We suggest, instead, a general astrobiological paradigm which might offer a physic... | 18,855,114 |
Myocardial strain in sub-acute peri-infarct myocardium. | In the absence of additional ischemic insults, the peri-infarct region surrounding the infarct myocardium can recover function. T2 weighted MRI signal is sensitive to edema and used to detect peri-infarct, salvageable myocardium. The main purpose of this study was to investigate the alterations in myocardial strain in ... | 18,855,121 |
Rates and severity of perforation from implantable cardioverter-defibrillator leads: a 4-year study. | Although recent case reports and one small single-year observational study report a substantially increased rate of perforation with the St. Jude Riata series defibrillator lead, these results have not been externally validated. From 2004 to 2007, 593 implantable cardioverter-defibrillator (ICD) implants were performed... | 18,855,128 |
Novel visualization of intracardiac pacing lead extractions: methodologies performed within isolated canine hearts. | Several methodologies are typically employed to extract chronically-implanted pacing leads including: laser catheter systems, radio frequency catheters, mechanical cutting catheters, and/or direct traction. In the present study, Visible Heart(R) methodologies were employed to obtain novel internal and external views of... | 18,855,129 |
The mechanical environment of bone marrow: a review. | Bone marrow is a viscous tissue that resides in the confines of bones and houses the vitally important pluripotent stem cells. Due to its confinement by bones, the marrow has a unique mechanical environment which has been shown to be affected from external factors, such as physiological activity and disuse. The mechani... | 18,855,142 |
Clinical significance and prognostic value of serum sHER-2/neu levels in patients with solid tumors. | The purpose of this study was to determine HER-2/neu in the serum of patients with solid tumors and to investigate its potential usefulness in predicting the clinical course of the disease. At the same time, we compared the ability of serum HER-2/neu, CA15.3, CA12-5, CA19-9, carcino embryonic antigen (CEA), and alpha-f... | 18,855,148 |
Midgut carcinoid patients display increased numbers of regulatory T cells in peripheral blood with infiltration into tumor tissue. | Our aim was to investigate the immune status of midgut carcinoid patients. Cancer patients generally display suppressed Th1-type immunity that disables mounting of an efficient anti-tumor response. However, little is known about patients with neuroendocrine midgut carcinoids. Circulating regulatory T cells were determi... | 18,855,160 |
The primary care diagnosis of dementia in Europe: an analysis using multidisciplinary, multinational expert groups. | To explore the extent of variation in the detection of dementia in primary care across Europe, and the potential for the development of European guidelines. A mixture of focus group and adapted nominal group methods involving 23 experts of different disciplines and from eight European countries. The diagnosis of dement... | 18,855,172 |
Early motherhood and mental health in midlife: a study of British and American cohorts. | Examine the relationship between early age at first birth and mental health among women in their fifties. Analysis of data on women from a British 1946 birth cohort study and the U.S. Health and Retirement Study birth cohort of 1931-1941. In both samples a first birth before 21 years, compared to a later first birth, i... | 18,855,176 |
Validation of a screening instrument for post-traumatic stress disorder in a clinical sample of older adults. | To determine the diagnostic validity of the Post Traumatic Disorder Checklist (PCL) against the 'gold standard' of the Clinician Administered PTSD Scale (CAPS) in a clinical sample of older adults. A cross-sectional validation study: participants were patients (65 years and over) being treated for medical and/or psychi... | 18,855,184 |
Active CD4+ helper T cells directly stimulate CD8+ cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet beta-cell ovalbumin antigen leading to diabetes. | CD4+ helper T (Th) cells play crucial role in priming, expansion and survival of CD8+ cytotoxic T lymphocytes (CTLs). However, how CD4+ Th cell's help is delivered to CD8+ T cells in vivo is still unclear. We previously demonstrated that CD4+ Th cells can acquire ovalbumin (OVA) peptide/major histocompatibility complex... | 18,855,194 |
High values of alpha (CXCL10) and beta (CCL2) circulating chemokines in patients with psoriatic arthritis, in presence or absence of autoimmune thyroiditis. | The possible role of circulating alpha and beta chemokines in psoriatic arthritis is not extensively studied. The aim of the study is to evaluate serum levels of CXCL10, CXCL9 (alpha) and CCL2 (beta) chemokines in a large series of psoriatic arthritis patients, with or without autoimmune thyroid (AT) disorders, and to ... | 18,855,195 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.