title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. | We investigated the clinical efficacy and safety of tocilizumab (a humanized anti-IL-6 receptor antibody) monotherapy in active rheumatoid arthritis (RA) patients with an inadequate response to low dose methotrexate (MTX). In a multicenter, double-blind, randomized, controlled trial, 125 patients were allocated to rece... | 18,979,150 |
Insufficient renal 1-alpha hydroxylase and bone homeostasis in aged rats with insulin resistance or type 2 diabetes mellitus. | This study aimed to explore the relationship between insufficient renal 1-alpha hydroxylase (IRH) and bone homeostasis in type 2 diabetes mellitus (T2DM) or insulin resistance (IR) and to investigate whether IR plays a major role in the pathogenesis of both IRH and bone loss in T2DM. The experimental animal models of T... | 18,979,155 |
The influence of ghrelin, adiponectin, and leptin on bone mineral density in healthy postmenopausal women. | The association of body fat mass (FM) with bone mineral mass (BMC) and bone mineral density (BMD) has been attributed to a mechanical load exerted on the skeleton by FM and by the effect of different hormones. The aim of the present study was to determine whether there is a relationship between ghrelin, adiponectin, an... | 18,979,162 |
Vitamin D and diabetes mellitus. | Better understanding of the physiological role of the vitamin-D system, in particular its potential effects on inflammatory and autoimmune conditions as well as on insulin secretion and possibly also on insulin resistance, increased the interest in its potential role in prevention and control of the diabetic condition,... | 18,979,202 |
DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response. | This study has investigated if individual DNA adducts formed in human glioma cells treated with (3)H-1-(2-chloroethyl)-1-nitrosourea ((3)H-CNU) could be used as molecular dosimeters of response after CENU treatment. The levels of individual DNA alkylation products were compared with the induction of cytotoxicity in six... | 18,979,209 |
Association between NSAIDs use and breast cancer risk: a systematic review and meta-analysis. | The association between non-steroidal anti-inflammatory drugs (NSAIDs) use and breast cancer has remained controversial. Therefore, an overall quantitative estimate of the association needs to be studied. A systematic review and meta-analysis was executed to explore the pooled estimate for relative risk (RR) and 95% co... | 18,979,210 |
Two-stage culture for producing berberine by cell suspension and shoot cultures of Berberis buxifolia Lam. | In vitro cultures of Berberis buxifolia were established using thidiazuron (4.5, 23 and 45 mM) or picloram (4 and 40 mM) as plant growth regulators for sustaining growth. For producing berberine, a two-stage culture was performed. In the first step, thidiazuron or picloram were used for biomass production followed by t... | 18,979,211 |
Fish muscle: the exceptional case of Notothenioids. | Fish skeletal muscle is an excellent model for studying muscle structure and function, since it has a very well-structured arrangement with different fiber types segregated in the axial and pectoral fin muscles. The morphological and physiological characteristics of the different muscle fiber types have been studied in... | 18,979,217 |
Effect of single-nucleotide polymorphisms of the 5' untranslated region of the human α-galactosidase gene on enzyme activity, and their frequencies in Portuguese caucasians. | The α-galactosidase gene (GLA) has three single-nucleotide polymorphisms in the 5' untranslated region of exon 1, respectively g.1150G>A, g.1168G>A, g.1170C>T. The g.1150A allele is associated with increased plasma α-galactosidase (α-Gal) activity in hemizygotes, while the others are regarded as biologically n... | 18,979,223 |
Cloning and characterization of Rv0621 gene related to surfactant stress tolerance in Mycobacterium tuberculosis. | To understand how Mycobacterium tuberculosis (M. tuberculosis) could survive in human lung, Genomic expression library of M. tuberculosis in Escherichia coli (E. coli) had been prepared. Taking advantage of the genetic simplicity of E. coli and the functional conservation of some prokaryote proteins, a surfactant stres... | 18,979,228 |
A novel vector for direct cloning PCR fragments by positive selection based on the lethal barnase. | A novel vector for direct PCR fragments cloning by positive selection, pBN, was constructed based on the lethal barnase from Bacillus amyloliquefaciens. Barnase was modified by inserting an additional insert at a pivotal Ile-54 site, which could take crucial affect on protein structure and absolute activity. The lacZ' ... | 18,979,229 |
The Turkish version of the National Eye Institute Refractive Error Quality of Life Instrument: translation, validity and reliability. | To translate the original 42-item National Eye Institute Refractive Error Quality of Life Questionnaire (NEI-RQL-42) into Turkish and to investigate its validity and reliability. The linguistic translation followed the international guidelines of forward and backward translation. Ninety-five consecutive subjects (37 my... | 18,979,231 |
Encapsulation of DNA and non-viral protein changes the structure of murine polyomavirus virus-like particles. | Asymmetrical-flow field flow fractionation with multiple-angle light scattering (AFFFF-MALS) was, for the first time, used to characterize the size of murine polyomavirus virus-like particles (MPV VLPs) packaged with either insect cell genomic DNA or non-viral protein. Encapsidation of both genomic DNA and non-viral pr... | 18,979,257 |
Caring for older patients: current attitudes and future plans of family medicine residents. | As the US population ages, more physicians will be needed to provide care for older patients. We characterized family medicine residents' plans to include care of the elderly and to patients in nursing homes in their future practices. We also assessed whether residents' plans were related to their attitudes toward the ... | 18,979,258 |
Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases. | Precisely defining the number and location of brain metastases is very important for establishing a treatment strategy for malignancies. Although magnetic resonance imaging (MRI) is now considered the best modality, various improvements in sequences are still being made. To prospectively compare the diagnostic ability ... | 18,979,271 |
Signaling across myoendothelial gap junctions--fact or fiction? | Gap junctions interconnect vascular cells homocellularly, thereby allowing the spread of signals along the vessel wall, which serve to coordinate vessel behavior. In addition, gap junctions provide heterocellular coupling between endothelial and vascular smooth muscle cells, creating so-called myoendothelial gap juncti... | 18,979,293 |
Hemichannel-mediated inositol 1,4,5-trisphosphate (IP3) release in the cochlea: a novel mechanism of IP3 intercellular signaling. | Inositol 1,4,5-trisphosphate (IP(3)) is an important second messenger that can trigger a Ca(2+) wave prolongated between cells. This intercellular signaling was found defective in some gap junction connexin deafness mutants. In this study, the mechanism underlying IP(3) intercellular signaling in the cochlea was invest... | 18,979,296 |
Effects of drospirenone on cardiovascular markers in human aortic endothelial cells. | The effect of the new progestogen drospirenone on biochemical markers in terms of cardiovascular effects was investigated in the presence and absence of aldosterone and compared to progesterone and the progestogens medroxyprogesterone acetate (MPA) and promegestone (R5020), and the antimineralocorticoid spironolactone.... | 18,979,300 |
Development and characterization of self-microemulsifying drug delivery system of tacrolimus for intravenous administration. | Tacrolimus (FK 506), a poorly soluble immunosuppressant is currently formulated in nonaqueous vehicle containing hydrogenated castor oil derivative for intravenous administration. Hydrogenated castor oil derivatives are associated with acute anaphylactic reactions. This proposes to overcome the problems of poor aqueous... | 18,979,309 |
Different involvement of radical species in irradiated and bystander cells. | To examine whether nitric oxide (NO) and other radical species are involved in radiation-induced bystander effects in normal human fibroblasts. Bystander effects were modeled by co-culture of non-irradiated cells with X-irradiated cells, and induction levels of micronuclei in co-cultured non-irradiated cells were exami... | 18,979,315 |
Surveillance results of depleted uranium-exposed Gulf War I veterans: sixteen years of follow-up. | As part of a longitudinal surveillance program, 35 members of a larger cohort of 77 Gulf War I veterans who were victims of depleted uranium (DU) "friendly fire" during combat underwent a 3-day clinical assessment at the Baltimore Veterans Administration Medical Center (VAMC). The assessment included a detailed medical... | 18,979,351 |
Efficacy and safety of dapsone as a second-line treatment in non-splenectomized adults with immune thrombocytopenic purpura. | In adults with immune thrombocytopenic purpura (ITP), steroids are usually proposed as first-line therapy, but long-term complete responses are obtained in no more than 20% of patients. For the remaining patients, splenectomy is considered the treatment of choice, with reported "cure" rates from 60-70%. However, the in... | 18,979,360 |
Cytoskeletons of X-linked GATA-1, G208S macrothrombocytes are deficient in talin. | An X-linked mutation in the GATA-1 transcription factor, G208S, causes macrothrombocytopenia and serious bleeding problems in affected male family members. The unique ultrastructural pathology of their platelets was described previously. The present investigation has evaluated the cytoskeletal proteins of the GATA-1, G... | 18,979,367 |
Reproducibility and standardized reporting of the vasodilator-stimulated phosphoprotein phosphorylation assay. | The platelet vasodilator-stimulated phosphoprotein (VASP) phosphorylation test is a new platelet function assay used to determine responsiveness to clopidogrel. We investigated if a commercially available VASP assay has a good reproducibility when conducted with half or quarter of the recommended volume of reagents. Se... | 18,979,368 |
Urinary transforming growth factor-beta(1), collagen IV and the effect of insulin in children at diagnosis of diabetes mellitus. | This study investigated whether metabolic derangement at diagnosis of diabetes mellitus affects the function of the basement membrane and the excretion of several components and whether insulin treatment can normalize this. It was designed to evaluate urinary excretion rates of transforming growth factor-beta(1) (TGF-b... | 18,979,373 |
Morphological properties of the action-observation cortical network in adolescents with low and high resistance to peer influence. | Children with high resistance to peer influences differ from their low-resistance counterparts in the degree of functional connectivity in fronto-parietal and prefrontal cortical networks. Here we explored the possibility that the degree of morphological similarities across the same cortical regions also varies as a fu... | 18,979,383 |
A cross-sectional assessment of utilization of addiction treatment among injection drug users in Kabul, Afghanistan. | The purpose of this study was to describe prior use of detoxification and addiction-treatment programs among injection drug users (IDUs) in Kabul, Afghanistan. From 2005-2006, IDUs (n = 464) recruited into this cross-sectional study completed an interviewer-administered questionnaire and whole blood rapid testing with ... | 18,979,391 |
Time courses of intrapartum asphyxia: neonatal characteristics and outcomes. | We compared neonatal characteristics and adverse outcome rates of neonates with hypoxic-ischemic encephalopathy following (1) prolonged partial asphyxia, (2) acute near-total intrapartum asphyxia, and (3) the two combined. The time course of the insult was determined individually by two authors from obstetric data and ... | 18,979,407 |
Spatial distribution of bluetongue surveillance and cases in Switzerland. | Swiss Bluetongue surveillance from mid 2007 to mid 2008 was a combination of monthly bulk milk testing of 200 cattle herds in zones of higher risk for vector presence and intensification of passive clinical surveillance. The spatial scan statistic and Moran's I statistic were used to determine clustering of surveillanc... | 18,979,419 |
[Postartum urinary retention - without clinical impact?]. | Postpartum urinary retention (PUR) continues to be a not very well understood clinical condition. The incidence varies in literature between 0.05 to 14.1%, after vaginal delivery, and between 3.3 to 24.1% after cesarean section, depending on the criteria used and reflecting differences in obstetrical practice. A common... | 18,979,432 |
[Fluorquinolone associated tendon rupture]. | We report the case of a 38-year-old patient with a rupture of the right Achilles tendon after physical exercise. A few days before he had been treated with ciprofloxacine 500mg bid for chlamydial urethritis. We discuss know risk factors for Achilles tendon ruptures and the possible contribution of ciprofloxacin and flu... | 18,979,434 |
[Shoulder and arm injuries in alpine ski racing. A survey on the frequency of these injuries with athletes of the Swiss Ski cadres and the regional cadres]. | The aim of this work was to examine the frequency and pattern of injuries of the upper extremity among Swiss Ski athletes and among regional team athletes. The injury pattern regarding shoulder and arm injuries in alpine skiers in Switzerland correlates with the previous literature. The shoulder joint is most frequentl... | 18,979,435 |
Engineering a reversible, high-affinity system for efficient protein purification based on the cohesin-dockerin interaction. | Efficient degradation of cellulose by the anaerobic thermophilic bacterium, Clostridium thermocellum, is carried out by the multi-enzyme cellulosome complex. The enzymes on the complex are attached in a calcium-dependent manner via their dockerin (Doc) module to a cohesin (Coh) module of the cellulosomal scaffoldin sub... | 18,979,459 |
Optimization of hydrophobic interaction chromatography using a mathematical model of elution curves of a protein mixture. | This paper describes a methodology for optimizing performance of hydrophobic interaction chromatography (HIC) for protein mixtures in which Rate Model simulations and evaluation of cost function are used. The system under study was HIC of a two-protein mixture (alpha-chymotrypsin and alpha-amylase), carried out with di... | 18,979,460 |
Asymmetric 1,4-addition of oxazolones to nitroalkenes by bifunctional cinchona alkaloid thiourea organocatalysts: synthesis of alpha,alpha-disubstituted alpha-amino acids. | An easy and simple synthetic approach to optically active alpha,alpha-quaternary alpha-amino acids using asymmetric organocatalysis is presented. The addition of oxazolones to nitroalkenes catalyzed by thiourea cinchona derivatives provides the corresponding alpha,alpha-quaternary alpha-amino acid derivatives with good... | 18,979,472 |
NK cells: new issues and challenges. Preface. | NK cells are innate lymphocytes crucial for surveillance against pathogens and tumors. Although the basic mechanisms through which NK cells operate have been established, many questions are still unresolved. Are all NK cells equal or can we identify subsets with distinct developmental origin and function? How do NK cel... | 18,979,520 |
Investigation of the effect of heating on the chemistry and antifactor Xa activity of enoxaparin. | The objective of this study was to investigate the effects of heating on the chemistry, physical properties and antifactor Xa activity of enoxaparin. Samples of enoxaparin heated at 70 degrees C lost 27% of their initial AFXa activity after 8 h, then activity increased to 94% of the initial activity over the next 4 h. ... | 18,979,533 |
Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles. | Polymeric micelles consisting of amphiphilic block copolymers have emerged as a promising carrier of various drugs, but unfortunately show a limited potential for encapsulating (solubilizing) such drugs. In this study, hybrid nanoparticles consisting of monomethoxypolyethyleneglycol-polylactide block copolymer (PEG-PLA... | 18,979,534 |
Biowaiver monographs for immediate release solid oral dosage forms: quinidine sulfate. | Literature data are reviewed relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing quinidine sulfate. Quinidine sulfate's solubility and permeability, its therapeutic use and index,... | 18,979,535 |
Is overcoming hormone resistance in breast cancer possible? | The administration of hormones plays a major role in the treatment of hormone receptor-expressing breast cancers (BCs), both in the adjuvant setting as well as in advanced disease. Hormone-responsive tumors almost uniformly develop resistance, either independently or as a result of exposure to hormones. Overcoming this... | 18,979,544 |
Neoadjuvant chemotherapy and targeted therapy in patients with liver metastases from colorectal cancer; medical oncologist's point of view. | Colorectal cancer (CRC) is one of the most frequent malignancies, with more than 1,000,000 new cases annually worldwide and more than 4,000 new cases annually in Bulgaria. Liver metastases (LM) occur in more than 50% of CRC patients, but curative liver resection is possible only in 15% of them, resulting in 5-year surv... | 18,979,545 |
Effects of immobilization beds on the dose in the entrance and exit dose region for Co-60, 4, 6 and 15 MV photons. | The aim of this study was to determine the effects of Styrofoam beds used for immobilization on build-up and exit dose regions for high energy photon beams. Build-up dose and exit dose measurements in central axis of Co-60 and 4, 6 and 15 MV photons at various field sizes and source to phantom distances were made in a ... | 18,979,554 |
Effects of infliximab and parenteral nutrition on albumin and fibrinogen synthesis rates in pediatric Crohn disease. | Tumor necrosis factor-alpha (TNF-alpha) may play a significant role in growth disturbance in pediatric Crohn disease. The aim of this study was to determine the effects of anti-TNF-alpha therapy on albumin and fibrinogen synthesis during both fasting and parenteral nutrition infusion in pediatric patients with active C... | 18,979,581 |
Ferrous gluconate and ferrous sulfate added to a complementary food distributed by the Mexican nutrition program Oportunidades have a comparable efficacy to reduce iron deficiency in toddlers. | To assess the efficacy of ferrous sulfate (FS) and ferrous gluconate (FG) as fortificants for a complementary baby food (Nutrisano) to improve the iron status and to reduce the prevalence of anemia in toddlers. Toddlers 12 to 30 months old were randomly assigned to receive either of 3 versions of Nutrisano fortified wi... | 18,979,587 |
Inevitable evolution: back to the origin and beyond the 20th century paradigm of contingent evolution by historical natural selection. | Since neo-Darwinism arose from the work of Darwin and Mendel evolution by natural selection has been seen as contingent and historical being defined by an a posteriori selection process with no a priori laws that explain why evolution on Earth has taken the direction of the major evolutionary trends and transitions ins... | 18,979,592 |
Effect of the first bath with chlorhexidine on skin colonization with Staphylococcus aureus in normal healthy term newborns. | A masked randomized clinical trial was conducted in 93 neonates who received the first bath with chlorhexidine (experimental) (n =44) or neutral liquid soap (control) (n =49). Three samples were collected for culture from the neonates' right axilla skin before bath, 30 min and 24 h after bath. Immediately before bath, ... | 18,979,599 |
Acute pancreatitis related to tigecycline: case report and review of the literature. | Tigecycline is a new broad-spectrum antibiotic. Nausea and vomiting are its most common side-effects. We describe here a case of severe acute pancreatitis related to tigecycline in order to highlight the possible occurrence of this adverse event and to remind clinicians to measure the lipase rate if in any doubt. | 18,979,610 |
Wild and semi-domesticated food plant consumption in seven circum-Mediterranean areas. | The use of local Mediterranean food plants is at the brink of disappearance. Even though there is relatively abundant information on inventories of wild edible taxa, there is also a crucial need to understand how these plants are consumed and when and how these consumption phenomena change over time and place around th... | 18,979,618 |
Substrate specificity determination of mouse implantation serine proteinase and human kallikrein-related peptidase 6 by phage display. | We constructed a random library of hexapeptides displayed on the surface of bacteriophage T7 to determine the substrate specificity of proteinases. The phage-displayed library was subjected to repeated rounds of biopanning with native implantation serine proteinase and recombinant human kallikrein-related peptidase 6 (... | 18,979,633 |
CrVI exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins. | A total of 195 subjects, including 141 exposed workers and 54 farmers, were recruited in China to evaluate the usefulness of chromium (Cr) in erythrocytes as a biomarker of exposure to CrVI. The levels of Cr in red blood cells (RBC) were remarkably elevated even in a group of workers routinely exposed to CrVI as low as... | 18,979,639 |
Evaluation of portacaval shunt patency with the differential glucose tolerance test. | A method has been described for establishing shunt patency by determining the difference in postprandial plasma glucose levels between a peripheral vein and the inferior vena cava at or near the site of the portal-systemic anastomosis. This tet was evaluated both in the laboratory with normal dogs before and after Eck ... | 18,979,657 |
New ADVANCEs in guidelines. | Recently published Guidelines for the Management of Arterial Hypertension jointly written by the European Society of Hypertension and the European Society of Cardiology are of great relevance to the diabetic population as a result of the elevated cardiovascular and renal risk that accompanies the simultaneous presence ... | 18,979,719 |
Prostate cancer probability maps based on ultrasound RF time series and SVM classifiers. | We describe a very efficient method based on ultrasound RF time series analysis and support vector machine classification for generating probabilistic prostate cancer colormaps to augment the biopsy process. To form the RF time series, we continuously record ultrasound RF echoes backscattered from tissue while the imag... | 18,979,734 |
A bayesian approach for liver analysis: algorithm and validation study. | We present a new method for the simultaneous, nearly automatic segmentation of liver contours, vessels, and metastatic lesions from abdominal CTA scans. The method repeatedly applies multi-resolution, multi-class smoothed Bayesian classification followed by morphological adjustment and active contours refinement. It us... | 18,979,735 |
Spatial consistency in 3D tract-based clustering statistics. | We propose a novel technique for tract-based comparison of DTI-indices between groups, based on a representation that is estimated while matching fiber tracts. The method involves a non-rigid registration based on a joint clustering and matching approach, after which a 3D-atlas of cluster center points is used as a fra... | 18,979,788 |
3D ultrasound-guided motion compensation system for beating heart mitral valve repair. | Beating heart intracardiac procedures promise significant benefits for patients, however, the fast motion of the heart poses serious challenges to surgeons. We present a new 3D ultrasound-guided motion (3DUS) compensation system that synchronizes instrument motion with the heart. The system utilizes the fact that the m... | 18,979,809 |
A constrained non-rigid registration algorithm for use in prostate image-guided radiotherapy. | A constrained non-rigid registration (CNRR) algorithm for use in updating prostate external beam image-guided radiotherapy treatment plans is presented in this paper. The developed algorithm is based on a multi-resolution cubic B-spline FFD transformation and has been tested and verified using 3D CT images from 10 sets... | 18,979,817 |
On classifying disease-induced patterns in the brain using diffusion tensor images. | Diffusion tensor imaging (DTI) provides rich information about brain tissue structure especially in the white matter, which is known to be affected in several diseases like schizophrenia. Identifying patterns of brain changes induced by pathology is therefore crucial to clinical studies. However, the high dimensionalit... | 18,979,832 |
A symmetry-based method for the determination of vertebral rotation in 3D. | In the past, a number of methods were proposed for quantitative assessment of vertebral rotation from three-dimensional (3D) images. However, these methods were based on manual identification of distinctive anatomical landmarks, required manual determination of cross-sections from 3D images, and measured only axial ver... | 18,979,836 |
Detection of DTI white matter abnormalities in multiple sclerosis patients. | The emergence of new modalities such as Diffusion Tensor Imaging (DTI) is of great interest for the characterization and the temporal study of Multiple Sclerosis (MS). DTI indeed gives information on water diffusion within tissues and could therefore reveal alterations in white matter fibers before being visible in con... | 18,979,840 |
[Osteoprotegerin mRNA/receptor activator of NF-kappaB ligand mRNA expressions in bone tissues of glucocorticoid-induced osteonecrosis of the femoral head]. | To investigate the expression levels of osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) mRNAs in bone tissues of the femoral head of the patients suffering glucocorticoid-induced osteonecrosis of the femoral head (ONFH), and to discuss the relationship between OPG/RANKL and ONFH. Between March ... | 18,979,868 |
[Preparation of CPC for tissue engineering artificial rib and a study on proliferation and adhesion of BMSCs on CPC]. | To access the possibility of CPC as a suitable scaffold for tissue engineering artificial rib by morphologic observation, adhesion experiments and cellar proliferation experiments. The 5 mm x 5 mm x 5 mm CPCs were prepared and the structure and components of CPC were compared with those of the normal human bone by micr... | 18,979,886 |
Antibody titers and response to vaccination against hepatitis A and B in pediatric patients with portal hypertension. | In Brazil, approximately 130 new cases of hepatitis A per 100,000 inhabitants occur annually and 15% of the population has been in contact with hepatitis B virus. Portal hypertension causes hypersplenism and reduces T cell production, which may lead to less effective response to hepatitis vaccination. The objective of ... | 18,979,898 |
[Influence of electrical cardioversion on troponine I and brain natriuretic peptide (NT-proBNP) levels in patients with persistent atrial fibrillation/flutter]. | The goal of our research was to determine how electrical cardioversion influences troponine I and brain natriuretic peptide (NT-proBNP) levels in patients with persistent atrial fibrillation (AF), without heart failure. Reaserch was conducted on 20 patients with AF. Before and after cardioversion levels of troponine I,... | 18,979,903 |
[Neonatal alloimmune thrombocytopenia in Croatia in 1997-2007]. | Neonatal alloimmune thrombocytopenia (NATP) is caused by maternal sensitization to paternal alloantigens on fetal platelets during pregnancy. Although the disease is rare, the severity of clinical picture and its sequels associated with central nervous system hemorrhage impose the need of an early diagnosis, and timely... | 18,979,905 |
[Epidemiological features of the injured in road traffic accidents in Shanghai]. | To provide reference data for enacting and revising the laws and regulations of the disability expertise. The epidemiological features of the disabled caused by road traffic accident in Shanghai during 2005 were retrospectively analyzed. The most common injuries were in extremities (53.3%), followed by head (23.3%), sp... | 18,979,919 |
Patient-based outcomes in patellofemoral arthroplasty. | This retrospective study evaluated the short-term functional outcome of patellofemoral arthroplasty using patient-based outcome measures. The study cohort included 17 patients who underwent patellofemoral arthroplasty (14 unilateral and 3 bilateral) between 1996 and 2005. Mean patient age was 56 years (range, 43-65 yea... | 18,979,927 |
The role of unicompartmental knee arthroplasty versus total knee arthroplasty in providing maximal performance and satisfaction. | Unicondylar knee arthroplasty (UKA) and total knee arthroplasty (TKA) are both recommended for the treatment of medial compartment osteoarthritis in the varus knee. Some authors report favorable functional results and patient satisfaction from TKA on the basis of extensive, long-term success of knee arthroplasty. Other... | 18,979,931 |
Why women leave therapy for stress incontinence. | Stress urinary incontinence (SUI) is the involuntary leakage of urine associated with effort, exertion, sneezing or coughing (Abrams et al, 2002) and is the most common type of incontinence in women (Hampel et al, 2004). In 2005, NHS Greater Glasgow introduced a primary care management of SUI pathway. However, a high p... | 18,979,961 |
[Arthroscopic repair of partial subcapularis tendon lesions. Simplified approach]. | We present a technical variation for arthroscopic subscapularis tendon repair. Sutures of isolated partial subscapularis tendon avulsions can be passed and fixed securely through an isolated anterolateral portal just over the rotator interval (mono-tunnel technique). Primarily a shoulder free of fixation devices is nee... | 18,979,983 |
[Effects of prophylaxis on QuantiFERON TB-2G responses among children]. | To study the effect of treatment of latent tuberculosis infection (LTBI) on QuantiFERON TB-2G (QFT-2G) test results. QFT-2G was used for a contact investigation in a junior high school and those positive or doubtful positive (TB Antigen-Nil response > or = 0.1 and < 0.35 IU/ml) were indicated for treatment of LTB... | 18,979,994 |
[Usefulness of the variable numbers of tandem repeats (VNTR) analysis for complex infections of Mycobacterium avium and Mycobacterium intracellulare]. | The bacilli which were isolated from a patient suspected of the mixed infections with Mycobacterium avium and Mycobacterium intracellulare, were analyzed. The genotypes of M. avium in the sedimented fractions of treated sputum and in some colonies isolated from Ogawa medium were compared by the Variable Numbers of Tand... | 18,979,997 |
Maximizing immune responses: the effects of covalent peptide linkage to beta-2-microglobulin. | Major histocompatability molecules (MHC) are involved in presentation of peptide antigens for recognition by the immune system. The density and stability of presented peptides is a critical parameter in determining the magnitude of the immune response. Increasing the half-life and density of an MHC class I-peptide comp... | 18,980,017 |
Understanding and treating triple-negative breast cancer. | Triple-negative breast cancer is a subtype of breast cancer that is clinically negative for expression of estrogen and progesterone receptors (ER/PR) and HER2 protein. It is characterized by its unique molecular profile, aggressive behavior, distinct patterns of metastasis, and lack of targeted therapies. Although not ... | 18,980,022 |
Education of children's nurses in Ireland: an update. | The first teaching hospital for sick children in Great Britain and Ireland opened in Dublin in 1821. From then, the development of sick children's nursing in Ireland followed a similar path to that in many other countries until a national report in 2000 recognised that post-registration pathways alone were unlikely to ... | 18,980,042 |
Minimize urinary incontinence: maximize physical activity in women. | Urinary incontinence (UI) is a common problem for women. Many women do not seek professional help for UI because of embarrassment or they believe UI is a normal part of aging. Research findings have shown that pelvic floor muscle strengthening is effective in reducing UI in middle-aged and older women. Women engaging i... | 18,980,101 |
Current concepts in the evaluation and management of erectile dysfunction. | The field of erectile dysfunction continues to evolve. Updated AUA Erectile Dysfunction Guidelines and the second Princeton Consensus Panel Guidelines, as well as updates regarding the oral PDE-5 inhibitors, are the focus of this article. | 18,980,102 |
Determination of cyclamate in foods by ultraperformance liquid chromatography/tandem mass spectrometry. | A highly sensitive and selective method that requires minimal sample preparation was developed for the confirmation and quantitation of cyclamate in a variety of foods by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). Sample preparation consisted of homogenization followed by extraction a... | 18,980,124 |
Thin-layer chromatography-densitometric measurements for determination of N-(hydroxymethyl)nicotinamide in tablets and stability evaluation in solutions. | A thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on silica gel F254 plates using chloroform-ethanol (2 + 3, v/v) mobile phase. The densitometric observations were made at 260 n... | 18,980,139 |
Analytical strategy for rapid identification and quantification of lubricant additives in mineral oil by high-performance thin-layer chromatography with UV absorption and fluorescence detection combined with mass spectrometry and infrared spectroscopy. | A simple strategy for identification and quantification of lubricant additives in mineral oil was demonstrated by high-performance thin-layer chromatography with UV absorption and fluorescence detection using various coupling options, e.g., with attenuated total reflectance infrared (ATR-IR) spectroscopy, Fourier trans... | 18,980,146 |
Polypyrrole-polysaccharide thin films characteristics: electrosynthesis and biological properties. | Polypyrrole-polysaccharide thin films were electropolymerized from starting solutions containing pyrrole and a polysaccharide, namely, heparin, chondroitin-4-sulphate or hyaluronic acid. The synthesized samples showed good chemical and physicochemical properties determined by the synthesis parameters such as the curren... | 18,980,193 |
Characterization of interfacial chemistry of adhesive/dentin bond using FTIR chemical imaging with univariate and multivariate data processing. | Fourier transform infrared (FTIR) chemical imaging can be used to investigate molecular chemical features of the adhesive/dentin interfaces. However, the information is not straightforward and is not easily extracted. The objective of this study was to use multivariate analysis methods, principal component analysis, an... | 18,980,198 |
Electrospun polyacrylonitrile nanofibrous biomaterials. | An N-halamine precursor, 3-(5'-methyl-5'-hydantoinyl)acetanilide (I), was synthesized in our laboratory and loaded onto electrospun polyacrylonitrile fiber to prepare nanosized biocidal materials, which could be rendered antimicrobial by exposure to household bleach. Differential scanning calorimetry was used to study ... | 18,980,199 |
Incidence of in situ and invasive vulvar cancer in the US, 1998-2003. | The human papillomavirus (HPV) vaccine has been shown to prevent precancerous lesions of the vulva with the potential to prevent a percentage of vulvar cancers. To provide a baseline picture before HPV vaccine implementation, the authors described vulvar cancer epidemiology by age, race, ethnicity, and histology in the... | 18,980,209 |
TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction through VEGF-mediated signaling. | VEGF and TGF-beta1 induce angiogenesis but have opposing effects on vascular endothelial cells: VEGF promotes survival; TGF-beta1 induces apoptosis. We have previously shown that TGF-beta1 induces endothelial cell apoptosis via up-regulation of VEGF expression and activation of signaling through VEGF receptor-2 (flk-1)... | 18,980,215 |
Prenatal behavior of the C57BL/6J mouse: a promising model for human fetal movement during early to mid-gestation. | The study of fetal neurobehavioral development in genetically altered mice promises a significant advance in our understanding of the prenatal origins of developmental disabilities in humans. Despite their importance, little is known about fetal neurobehavioral development in mice. In this study, we observed prenatal b... | 18,980,217 |
HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses. | HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity. We examined HIP/RPL29's ability to modulate actions of HS-binding growth factors (HBGFs) in angiogenesis. Between 1 and 2.5 microg/ml (ca. 60-150 nM), HIP/RPL29 inhibited HBGF-stimulated endot... | 18,980,226 |
Effects of heat shock on the distribution and expression levels of nuclear proteins in HeLa S3 cells. | Cumulating evidence has led to the idea that nuclear functions such as DNA replication, RNA transcription, RNA splicing and nucleocytoplasmic transport are facilitated by a proteinaceous architectural framework within the nuclear compartment and at the nuclear envelope. In the present study, we have used immunofluoresc... | 18,980,230 |
Cell size increased in tissues from transgenic mice overexpressing a cell surface growth-related and cancer-specific hydroquinone oxidase, tNOX, with protein disulfide-thiol interchange activity. | tNOX (ENOX2), a cancer-specific and growth-related cell surface protein with protein disulfide-thiol interchange and hydroquinone (NADH) oxidase activities was overexpressed in a transgenic mouse model. Female transgenic mice grew faster than wild type as did embryonic fibroblast cells prepared from the transgenic mice... | 18,980,249 |
Methylene blue-mediated photodynamic therapy induces mitochondria-dependent apoptosis in HeLa cell. | Methylene blue (MB), a widely studied reagent, is investigated in this work for its usage in photodynamic therapy (PDT). PDT has been proved to be highly effective in the treatment of different types of cancers. Previous studies showed MB has both high affinity for mitochondria and high photodynamic efficiency. To eluc... | 18,980,251 |
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry monitoring of anthocyanins in extracts from Arabidopsis thaliana leaves. | Anthocyanins are secondary plant metabolites ubiquitous in the plant kingdom. They have different biological activities, so monitoring their content in plant tissue or in feed/food derived from plants may be an important task in different projects from various fields of molecular biology and biotechnology. Profiling of... | 18,980,256 |
Effects of dietary caffeine on EEG, performance and mood when rested and sleep restricted. | Until recently, little account had been taken of the confounding effects of caffeine withdrawal and withdrawal reversal when examining the net effects of dietary caffeine. By including a manipulation involving sleep restriction, the present study aimed to extend recent findings from research in which caffeine withdrawa... | 18,980,263 |
Years of potential life lost and productivity costs because of cancer mortality and for specific cancer sites where human papillomavirus may be a risk factor for carcinogenesis-United States, 2003. | Although years of potential life lost (YPLL) and mortality-related productivity costs comprise a substantial portion of the burden of cancers where human papillomavirus (HPV) may be a risk factor for carcinogenesis (called HPV-associated cancers in this report), estimates of these costs are limited. The authors estimat... | 18,980,277 |
Human papillomavirus and cervical cancer behavioral surveillance in the US. | In the US, federal and state behavioral surveillance systems routinely monitor self-reported sexual behavior and Papanicolaou (Pap) test use to identify high-risk populations, trends, and disparities and to guide and evaluate interventions for cervical cancer prevention and control. Clinical uptake of human papillomavi... | 18,980,284 |
Atypical squamous cells, cannot exclude a high-grade intraepithelial lesion and its clinical significance in postmenopausal, pregnant, postpartum, and contraceptive-use patients. | Previous studies have confirmed the low predictive value of a diagnosis of atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion (ASC-H) in a Papanicolaou (Pap) smear for subsequent high-grade dysplasia in the postmenopausal age group. It appears plausible that the decrease in estrogen in... | 18,980,288 |
Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature. | Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is important to reco... | 18,980,290 |
Investigation of silver-containing layered materials and their interactions with primary amines using solid-state 109Ag and 15N NMR spectroscopy and first principles calculations. | Silver-containing layered networks of the form [Ag(L)] (L = 4-pyridinesulfonate or p-toluenesulfonate) were treated with primary amines in different ratios. The structures of the parent supramolecular networks are well-known; however, their interactions with primary amines lead to the formation of new layered materials... | 18,980,301 |
Second-order self-organization in coordination-driven self-assembly: exploring the limits of self-selection. | Self-organization during the self-assembly of a series of functionalized bispyridyl organic donors with complementary di-Pt(II) acceptors into supramolecular rhomboids and rectangles is explored. The connectivity and location of functional groups on the organic donors ensures that they do not interfere sterically or el... | 18,980,302 |
Enantioselective total syntheses of trichodermamides A and B. | Starting from commercially available (-)-quinic acid, the enantioselective total syntheses of trichodermamides A and B were achieved. The key reactions involve the stereoselective construction of the oxazine ring via an intramolecular epoxide ring opening reaction and an EDCI-assisted peptide coupling reaction. | 18,980,316 |
Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion. | Enzyme-based hybrid hydrogels were prepared by covalently incorporating an adenylate kinase mutant, possessing two thiol groups, into HPMA copolymer- or PEG-based hydrogel structures. The nanoscale conformational change of enzyme, triggered by substrate recognition, translated into macroscopic motion of hydrogels. | 18,980,321 |
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