title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. | Pseudomonas aeruginosa is a well-studied opportunistic pathogen that is particularly known for its intrinsic antimicrobial resistance, diverse metabolic capacity, and its ability to cause life threatening infections in cystic fibrosis patients. The Pseudomonas Genome Database (http://www.pseudomonas.com) was originally... | 18,978,025 |
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. | Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its application in many types of cancer including prostate. We report a unique strategy to deliver cisplatin to prostate cancer cells by constructing Pt(IV)-encapsulated prostate-specific membrane ant... | 18,978,032 |
The action of high K+ and aglycaemia on the electrical properties and synaptic transmission in rat intracardiac ganglion neurones in vitro. | We have investigated the action of two elements of acute ischaemia, high potassium and aglycaemia, on the electrophysiological properties and ganglionic transmission of adult rat intracardiac ganglion (ICG) neurones. We used a whole-mount ganglion preparation of the right atrial ganglion plexus and sharp microelectrode... | 18,978,036 |
The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori. | Helicobacter pylori colonizes the acidic gastric environment, in contrast to all other neutralophiles, whose acid resistance and tolerance responses allow only gastric transit. This acid adaptation is dependent on regulation of gene expression in response to pH changes in the periplasm and cytoplasm. The cytoplasmic hi... | 18,978,046 |
Improved thermostability and acetic acid tolerance of Escherichia coli via directed evolution of homoserine o-succinyltransferase. | In Escherichia coli, growth is limited at elevated temperatures mainly because of the instability of a single enzyme, homoserine o-succinyltransferase (MetA), the first enzyme in the methionine biosynthesis pathway. The metA gene from the thermophile Geobacillus kaustophilus cloned into the E. coli chromosome was found... | 18,978,085 |
Effect of diaphragm and lubricant gel provision on human papillomavirus infection among women provided with condoms: a randomized controlled trial. | To estimate the effect of providing women with a latex diaphragm, lubricant gel, and male condoms (intervention) compared with condoms alone (control) on human papillomavirus (HPV) incidence and clearance. Participants were 2,040 human immunodeficiency virus (HIV)-negative Zimbabwean women enrolled in a randomized tria... | 18,978,097 |
Cigarette smoking, androgen levels, and hot flushes in midlife women. | To test the hypothesis that cigarette smoking is associated with hot flushes through a mechanism involving androgen levels, progesterone levels, sex hormone-binding globulin levels, or the ratio of androgens to estrogens. Women with and without hot flushes were recruited from Baltimore, Maryland, and the surrounding co... | 18,978,103 |
Effective treatment of vaginal atrophy with an ultra-low-dose estradiol vaginal tablet. | To evaluate the efficacy of ultra-low-dose 10-microgram 17beta-estradiol (E2) vaginal tablets for treatment of vaginal atrophy. Postmenopausal women (N=309) were randomly assigned to 10-microgram E2 or placebo vaginal tablets for 52 weeks in a multicenter, double-blind study. Primary efficacy endpoints included change ... | 18,978,105 |
A protocol of dual prophylaxis for venous thromboembolism prevention in gynecologic cancer patients. | To evaluate a quality improvement protocol for venous thromboembolism prevention in postoperative gynecologic cancer patients. On January 1, 2006, we initiated a universal protocol of dual prophylaxis with sequential compression devices and three times daily heparin (or daily low molecular weight heparin) until dischar... | 18,978,110 |
Activation of the fibrinolytic cascade early in pregnancy among women with spontaneous preterm birth. | To evaluate the association of early pregnancy concentrations of thrombin-antithrombin III complex with subsequent spontaneous preterm birth. In a nested case-control study, thrombin-antithrombin III complex was measured in plasma before 20 weeks of gestation (mean 9.9 weeks) among women without chronic conditions, pre... | 18,978,114 |
Lung cancer gene associated with COPD: triple whammy or possible confounding effect? | Recently, several large genome-wide association studies have identified a putative "lung cancer" locus in the nicotinic acetylcholine receptor subunit genes (nAChR) on 15q25. However, these findings may be confounded by the presence of chronic obstructive pulmonary disease (COPD), which is also strongly associated with... | 18,978,134 |
Cell kinetics and gene expression changes in colorectal cancer patients given resistant starch: a randomised controlled trial. | This study investigated the effects of oral supplementation of resistant starch (RS) on tumour cell and colonic mucosal cell kinetics and on gene expression in patients with colorectal cancer (CRC), and its potential role in colon cancer prevention. 65 patients with CRC were randomised to treatment with RS or ordinary ... | 18,978,177 |
Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats. | The extent and molecular mechanisms governing plasma extravasation and formation of ascites in cirrhosis are unknown. Vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Ang-2) are endogenous substances with powerful vascular permeability effects. We assessed regional blood flow, vascular leakage, mRNA an... | 18,978,178 |
A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome. | The ubiquitin proteasome system (UPS) degrades abnormal proteins and most unneeded normal proteins, thereby playing a critical role in protein homeostasis in the cell. Proteasome inhibition is effective in treating certain forms of cancer, while UPS dysfunction is increasingly implicated in the pathogenesis of many sev... | 18,978,187 |
Impact of diet and stress on the development of preeclampsia-like symptoms in p57kip2 mice. | The cyclin-dependent kinase inhibitor p57(kip2) regulates the cell cycle of trophoblastic cells. It has been established by a Japanese group that the heterozygous p57(kip2) knockout (p57(-/+)) mice are a good model of preeclampsia as they develop hypertension, proteinuria, and placental pathology. However, apart from t... | 18,978,188 |
A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. | Insulin resistance is an increasingly prevalent condition in humans that frequently clusters with disorders characterized by left ventricular (LV) pressure overload, such as systemic hypertension. To investigate the impact of insulin resistance on LV remodeling and functional response to pressure overload, C57BL6 male ... | 18,978,196 |
Mechanism and rate of glucose absorption differ between an Australian honeyeater (Meliphagidae) and a lorikeet (Loriidae). | Efficient mechanisms of glucose absorption are necessary for volant animals as a means of reducing mass during flight: they speed up gut transit time and require smaller volume and mass of gut tissue. One mechanism that may be important is absorption via paracellular (non-mediated) pathways. This may be particularly tr... | 18,978,218 |
A microarray-based transcriptomic time-course of hyper- and hypo-osmotic stress signaling events in the euryhaline fish Gillichthys mirabilis: osmosensors to effectors. | Cells respond to changes in osmolality with compensatory adaptations that re-establish ion homeostasis and repair disturbed aspects of cell structure and function. These physiological processes are highly complex, and require the coordinated activities of osmosensing, signal transducing and effector molecules. Although... | 18,978,229 |
Pre-operative predictors of the length of hospital stay in total knee replacement. | In Scotland, the number of primary total knee replacements performed annually has been increasing steadily. The price of the implant is fixed but the length of hospital stay is variable. We prospectively investigated all patients who underwent primary unilateral total knee replacement in the Scottish region of Fife, be... | 18,978,261 |
The epidemiology of fractures in adolescents with reference to social deprivation. | A relationship between social deprivation and the incidence of fracture in adolescents has not previously been shown. We have used a complete fracture database to identify adolescents who sustained fractures in 2000. The 2001 Scottish census was used to obtain age-specific population and deprivation data according to t... | 18,978,270 |
Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice. | Fenofibrate (FF) has previously been shown to induce hepatocellular neoplasia in a conventional mouse bioassay (NDA 1993), but there has been no report to examine the carcinogenic susceptibility of rasH2 mice to this chemical. In the present study, male rasH2 mice were subjected to a two-thirds partial hepatectomy (PH)... | 18,978,307 |
Involving patients in decisions during psychiatric consultations. | Patient involvement in the decision-making process is a key element for good clinical practice. Few data are available on patient involvement in psychiatry. To assess in a psychiatric out-patient context how psychiatrists involve patients in therapeutic decisions and to determine the extent to which patient and psychia... | 18,978,325 |
Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups. | Previous studies demonstrated that perinatal exposure to polybrominated diphenyl ethers (PBDEs), a major class of brominated flame retardants, may affect thyroid hormone (TH) concentrations by inducing hepatic uridinediphosphate-glucoronosyltransferases (UGTs). This study further examines effects of the commercial pent... | 18,978,342 |
A phase I study of periocular topotecan in children with intraocular retinoblastoma. | To identify the maximum tolerated dose and dose-limiting toxicity of periocular topotecan in patients with relapsed or resistant intraocular retinoblastoma who are facing imminent enucleation. For this phase I study, a starting dose of 0.5 mg of periocular topotecan administered through a 25-gauge needle was given with... | 18,978,345 |
Evf, a virulence factor produced by the Drosophila pathogen Erwinia carotovora, is an S-palmitoylated protein with a new fold that binds to lipid vesicles. | Erwinia carotovora are phytopathogenic Gram-negative bacteria of agronomic interest as these bacteria are responsible for fruit soft rot and use insects as dissemination vectors. The Erwinia carotovora carotovora strain 15 (Ecc15) is capable of persisting in the Drosophila gut by the sole action of one protein, Erwinia... | 18,978,353 |
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. | Fanconi anemia (FA) is a heritable human cancer-susceptibility disorder, delineating a genetically heterogenous pathway for the repair of replication-blocking lesions such as interstrand DNA cross-links. Here we demonstrate that one component of this pathway, FANCJ, is a structure-specific DNA helicase that dissociates... | 18,978,354 |
Immune function effects of dental amalgam in children: a randomized clinical trial. | Dental amalgam is a widely used restorative material containing 50 percent elemental mercury that emits mercury vapor. No randomized clinical trials have determined whether there are adverse immunological effects associated with this low-level mercury exposure in children. The objective of this study was to evaluate a ... | 18,978,388 |
A comparison of two nonoperative methods of idiopathic clubfoot correction: the Ponseti method and the French functional (physiotherapy) method. | In the treatment of idiopathic clubfeet, the Ponseti method and the French functional method have been successful in reducing the need for surgery. The purpose of this prospective study was to compare the results of these two methods at one institution. Patients under three months of age with previously untreated idiop... | 18,978,399 |
Cervical disc arthroplasty compared with arthrodesis for the treatment of myelopathy. | Although there have been case reports describing the use of cervical disc arthroplasty for the treatment of myelopathy, there is a concern that motion preservation may maintain microtrauma to the spinal cord, negatively affecting the clinical results. As we are not aware of any studies on the use of arthroplasty in thi... | 18,978,404 |
Three-dimensional corrective osteotomy of malunited fractures of the upper extremity with use of a computer simulation system. | Three-dimensional anatomical correction is desirable for the treatment of a long-bone deformity of the upper extremity. We developed an original system, including a three-dimensional computer simulation program and a custom-made surgical device designed on the basis of simulation, to achieve accurate results. In this s... | 18,978,406 |
Effect of micrometer-scale roughness of the surface of Ti6Al4V pedicle screws in vitro and in vivo. | Titanium implants that have been grit-blasted and acid-etched to produce a rough microtopography support more bone integration than do smooth-surfaced implants. In vitro studies have suggested that this is due to a stimulatory effect on osteoblasts. It is not known if grit-blasted and acid-etched Ti6Al4V implants also ... | 18,978,418 |
Real-time motion-adaptive delivery (MAD) using binary MLC: II. Rotational beam (tomotherapy) delivery. | TomoTherapy delivery is controlled by a planned, projection-wised leaf sequence (sinogram) that is optimized during treatment planning. In this paper, we developed a software solution for real-time motion compensation that delivers helical TomoTherapy plans without modifying the hardware and workflow of the TomoTherapy... | 18,978,445 |
When to initiate immunotherapy in children with allergic disease? Lessons from the paediatric studies. | Immunotherapy is the only treatment that may alter the natural course of disease. From that perspective, treatment in children might be very valuable. An overview of the recent literature is discussed. The recent literature shows a shift from injectable immunotherapy to noninjectable routes of administration. A systema... | 18,978,473 |
Sublingual immunotherapy: what have we learnt from the 'big trials'? | Recent systematic reviews support the use of sublingual immunotherapy for allergic rhinoconjunctivitis in adults, whereas data in children have been less convincing. The present review evaluates three recent 'definitive' trials in adults and one in children. Two large independent randomized controlled trials of grass a... | 18,978,475 |
The effects of galantamine on psychopathology in chronic stable schizophrenia. | Galantamine is an acetylcholinesterase inhibitor and an allosteric modulator of the alpha4beta2 and alpha7 nicotinic receptors. There are several case reports describing the potential benefits of galantamine for negative symptoms associated with schizophrenia. This secondary analysis describes the effects of galantamin... | 18,978,489 |
Impulse control disorders arising in 3 patients treated with rotigotine. | We report 3 cases of impulse control disorders (ICDs) that developed in patients with Parkinson disease treated with the novel dopamine agonist, rotigotine. Three patients were identified retrospectively who developed symptoms of an ICD while taking rotigotine. The ICD symptoms developed at 4, 5, and 8 years after diag... | 18,978,496 |
Long-term use of mood stabilizers and its impact on the quality of life of chinese patients with schizophrenia. | To date, no studies have investigated the prescription patterns of mood stabilizers (MSs) in Chinese patients with schizophrenia. This study examined the frequency and sociodemographic and clinical correlates of MS prescription for outpatients with schizophrenia in Hong Kong (HK) and Beijing (BJ), China. Five hundred f... | 18,978,504 |
Proteomics blood testing to distinguish chronic rhinosinusitis subtypes. | To evaluate the potential of surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) proteomic profiling of serum samples to distinguish chronic rhinosinusitis subtypes. Translational study of serum samples from prospectively enrolled patients undergoing sinus surgery. Patients unde... | 18,978,510 |
Nationwide survey of palivizumab for respiratory syncytial virus prevention in Japanese children with congenital heart disease. | A questionnaire study was performed to determine the current status of palivizumab prophylaxis against respiratory syncytial virus infection in Japanese children with congenital heart disease <2 years of age. Palivizumab prophylaxis decreased the respiratory syncytial virus hospitalization rate by 42.8%. | 18,978,515 |
CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. | Cyclosporine is a substrate of cytochrome P450 (CYP) 3A and of the transporter ABCB1, for which polymorphisms have been described. In particular, CYP3A5 *3/*3 genotype results in the absence of CYP3A5 activity, whereas CYP3A7 *1/*1C genotype results in high CYP3A7 expression in adults. Log-transformed dose-adjusted cyc... | 18,978,522 |
Pulmonary metastasectomy: a survey of current practice amongst members of the European Society of Thoracic Surgeons. | Currently, no randomized trials exist to guide thoracic surgeons in the field of pulmonary metastasectomy. This study investigates the current clinical practice among European Society of Thoracic Surgeon (ESTS) members. A Web-based questionnaire was created exploring the clinical approach to lung metastasectomy. All ES... | 18,978,560 |
Pathway targets to explore in the treatment of non-small cell lung cancer. | With a 5-year survival rate of only 16%, improvements in therapeutic strategies for the treatment of non-small cell lung cancer (NSCLC) are still warranted. Published prognostic gene expression classification signatures in NSCLC overlap poorly across studies. We hypothesized that different NSCLC microarray datasets wil... | 18,978,571 |
Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. | Human herniated disc tissues and rat nucleus pulposus (NP) cells were used following approval by the authors' institutional Human Ethics Review Committee and Animal Care and Use Committee. To determine the expression of leptin and its functional receptor in herniated disc tissues, and to elucidate whether leptin can st... | 18,978,578 |
Neuropathic lower extremity pain following Dunn-McCarthy instrumentation. | Retrospective review of all patients with intact spinal cords, who had posterior spinal fusion (PSF) to the pelvis with Dunn-McCarthy instrumentation. Inclusion criteria were communicative patients with Dunn-McCarthy instrumentation, functioning spinal cords, and sensate lower extremities. We excluded patients with mye... | 18,978,581 |
The effect of pulsed jet lavage in vertebroplasty on injection forces of polymethylmethacrylate bone cement, material distribution, and potential fat embolism: a cadaver study. | In vitro testing of vertebroplasty techniques including pulsed jet-lavage for fat and marrow removal in human cadaveric lumbar and thoracic vertebrae. To develop jet-lavage techniques for vertebroplasty and investigate their effect on cement distribution, injection forces, and fat embolism. The main complications of ce... | 18,978,585 |
Augmentation of pedicle screw fixation strength using an injectable calcium sulfate cement: an in vivo study. | An in vivo landrace model of cement augmentation of pedicle screw was established, and axial pull-out tests and histological analysis were performed. To investigate the long-term in vivo biomechanical performance of pedicle screws augmented with calcium sulfate cement. Little information is available on the long-term b... | 18,978,590 |
Anterior cervical fusion using a polyetheretherketone cage containing a bovine xenograftp: three to five-year follow-up. | Retrospective review of an anterior polyetheretherketone (PEEK) cage incorporated with a bovine xenograft to treat disorders of the cervical disc. To assess the achievement of fusion by PEEK cage with xenograft radiographically and clinically when used to perform ACDF. Anterior cervical discectomy and fusion is the the... | 18,978,593 |
Kinematic alterations due to different loading schemes in early acceleration sprint performance from starting blocks. | The purpose of this study was to examine the changes to block start and early acceleration sprint kinematics with resisted sled towing. Ten male sprinters performed 12 sprints (four each of unresisted and approximately 10 and 20% body mass [BM]) for 10 m from a block start. Two-dimensional high-speed video footage (250... | 18,978,610 |
Closed-kinetic chain upper-body training improves throwing performance of NCAA Division I softball players. | Closed-kinetic chain resistance training (CKCRT) of the lower body is superior to open-kinetic chain resistance training (OKCRT) to improve performance parameters (e.g., vertical jump), but the effects of upper-body CKCRT on throwing performance remain unknown. This study compared shoulder strength, power, and throwing... | 18,978,626 |
Performance evaluation of a high-speed inertial exercise trainer. | A high-speed, low-resistance inertial exercise trainer (IET, Impulse Training Systems, Newnan, Ga) is increasingly employed in rehabilitative and athletic performance settings. Repetitions on an IET are done through a large range of motion because multijoint movements occur over more than one plane of motion, with no l... | 18,978,629 |
Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition. | The menopausal transition is characterized by irregular menstrual cycles and unpredictable hormone levels, including dramatic swings in estradiol (E2). An increasing number of studies have found variable high E2 and low luteal phase progesterone occur with progression of Stages of Reproductive Aging Workshop (STRAW)sta... | 18,978,637 |
A familial CHARGE syndrome with a CHD7 nonsense mutation and new clinical features. | The autosomal dominant CHARGE syndrome (MIM musical sharp214800) is caused by mutations in the CHD7 gene. It is usually sporadic but a few cases with gonadal mosaicism and familial inheritance have been reported. We describe a familial CHARGE syndrome in a two-generation Finnish family with a nonsense mutation in the C... | 18,978,652 |
Tests and measures used by specialist physical therapists when examining patients with stroke. | Examination procedures preferred by physical therapists have not been documented either specifically or comprehensively. The purpose of this study was to determine which tests and measures are used most frequently by specialists in the examination of adults with stroke. Physical therapy specialists were identified as h... | 18,978,668 |
Influence of spray-dried hydroxyapatite-5-fluorouracil granules on cell lines derived from tissues of mesenchymal origin. | In our previous work we described the preparation and characterization of spray dried hydroxyapatite micro granules loaded with 5-fluorouracil (5-FU). These loaded particles are used as a model drug delivery system (DDS). In this study we examined the in vitro response of two cell lines derived from different tissues t... | 18,978,702 |
Progressive rise of c fos expression from premalignant to malignant lesions of oral cavity. | Oral cancer is a worldwide phenomenon. It is thought to develop in a number of premalignant lesions. Protooncogene c fos is a known transformer of premalignant to malignant lesions. However, its role in oral carcinogenesis is not yet known. A total of 130 cases were studied comprising of premalignant lesions (n=50), sq... | 18,978,706 |
Cell proliferation and apoptosis in keratocystic odontogenic tumors. | Keratocystic odontogenic tumors (KOTs), also known as odontogenic keratocysts, were recently classified as a benign neoplasia due to the aggressive clinical behavior. Although several studies have shown the high proliferative activity of the epithelial lining, few studies have evaluated apoptosis in KOTs. Therefore, th... | 18,978,709 |
Prevalence of oral lesions in patients with psoriasis. | To determine the prevalence of oral lesions (OL) in patients with psoriasis, and compare these findings with the ones found in patients without this condition. In the present observational and comparative study, we evaluated 207 patients, with and without psoriasis, attending the dermatological consulting service of a ... | 18,978,710 |
Inferior alveolar nerve transposition with involvement of the mental foramen for implant placement. | Inferior Alveolar Nerve (IAN) transposition is an option for prosthetic rehabilitation in cases of moderate or even severe bone reabsorption for patients that do not tolerate removable dentures. The aim of the present report is to describe an inferior alveolar nerve transposition with involvement of the mental foramen ... | 18,978,714 |
Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer. | The Y-Box-binding protein-1, a member of the cold-shock domain DNA- and RNA-binding protein superfamily, is known to mediate chemoresistance. The aim of this study was to determine the expression of Y-Box-binding protein-1 in nasopharyngeal cancer in vitro and in tumor tissue samples as well as analyze the clinicopatho... | 18,978,732 |
Metachromatic leukodystrophy: an overview of current and prospective treatments. | Nowadays, different treatment options are available for an extending list of lysosomal storage diseases (LSDs). Hematopoietic stem cell transplantation (HSCT) can benefit selected subsets of patients with some LSDs, but results have been poor in several other disorders, including metachromatic leukodystrophy (MLD), out... | 18,978,739 |
Teasing, disordered eating behaviors, and psychological morbidities among overweight adolescents. | To assess whether weight-related teasing is associated with weight control behaviors, disordered eating thoughts and behaviors, and psychological comorbidities in overweight adolescents. A sample of 46 male and 84 female adolescents completed a survey assessing teasing frequency, sources of teasing (peers and family), ... | 18,978,759 |
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. | Alternative pre-messenger RNA splicing influences development, physiology and disease, but its regulation in humans is not well understood, partially because of the limited scale at which the expression of specific splicing events has been measured. We generated the first genome-scale expression compendium of human alt... | 18,978,788 |
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. | We carried out the first analysis of alternative splicing complexity in human tissues using mRNA-Seq data. New splice junctions were detected in approximately 20% of multiexon genes, many of which are tissue specific. By combining mRNA-Seq and EST-cDNA sequence data, we estimate that transcripts from approximately 95% ... | 18,978,789 |
Lung cancer susceptibility locus at 5p15.33. | We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the i... | 18,978,790 |
Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer. | Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. delta-Catenin (CTNND2) is overexpressed in cancer, although the mechanisms of its upregulation are highly variable. Here we report that in prostate cancer, the methylation of CpG islands in th... | 18,978,817 |
Adaptation and perceptual norms in color vision. | Many perceptual dimensions are thought to be represented relative to an average value or norm. Models of norm-based coding assume that the norm appears psychologically neutral because it reflects a neutral response in the underlying neural code. We tested this assumption in human color vision by asking how judgments of... | 18,978,861 |
Plurality of principal angles for a given pseudo-Brewster angle when polarized light is reflected at a dielectric-conductor interface. | The pseudo-Brewster angle phi(pB) of minimum reflectance for p-polarized light and the principal angle phi at which incident linearly polarized light of the proper azimuth is reflected circularly polarized are considered as functions of the complex relative dielectric function epsilon of a dielectric-conductor interfac... | 18,978,867 |
Temperature dependence of a macrobending edge filter based on a high-bend loss fiber. | The temperature dependence of a macrobending bare-fiber-based edge filter is investigated both theoretically and experimentally. The fiber used is a high-bend loss fiber, type 1060XP. The experimental results show a good agreement with the proposed theoretical model over a temperature range from 0 degrees C to 80 degre... | 18,978,890 |
Experimental investigation of combined four-wave mixing and Raman effect in the normal dispersion regime of a photonic crystal fiber. | We study the effect of stimulated Raman scattering on four-wave mixing sidebands generated by pumping in the normal dispersion regime of a photonic crystal fiber. Q-switch nanosecond pulses at 1064 nm are used to generate signal and idler wavelengths by degenerate four-wave mixing. These three waves generate their own ... | 18,978,896 |
Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides. | Using femtosecond laser writing, optical waveguides were monolithically integrated into a commercial microfluidic lab-on-a-chip device, with the waveguides intersecting a microfluidic channel. Continuous-wave laser excitation through these optical waveguides confines the excitation window to a width of 12 microm, enabl... | 18,978,901 |
Cancellation of Raman pulse walk-off by slow light. | We theoretically demonstrate in a nonlinear optical fiber system with a narrowband Raman gain that pulse walk-off between the pump and the Raman Stokes waves can be fully compensated for by Raman slow light, leading to group-velocity matching between the interacting waves, greater useful interaction length, and thereby... | 18,978,902 |
Dual-channel optical phase measurement system for improved precision. | Developments and applications of a dual-channel phase measurement system are being proposed and experimentally studied by utilizing an optical homodyne technique. In this measurement system, the phase modulation was adopted by using a near-stable Zn-indiffused lithium niobate phase modulator. The proposed method was su... | 18,978,910 |
Improved design of polarization-maintaining photonic crystal fibers. | We propose the realization of single-polarization operation in highly birefringent photonic crystal fibers. The suppression of one of the polarization states is realized by introducing index-matched cladding defect waveguides. The leakage loss of the index-matched polarization state can be enhanced by nearly 4 orders o... | 18,978,914 |
Two-color surface lattice solitons. | We study the properties of surface solitons generated at the edge of a semi-infinite photonic lattice in nonlinear quadratic media, namely two-color surface lattice solitons. We analyze the impact of phase mismatch on the existence and stability of nonlinear surface modes and find novel classes of two-color twisted sur... | 18,978,917 |
Adolescents' performance on delay and probability discounting tasks: contributions of age, intelligence, executive functioning, and self-reported externalizing behavior. | Healthy adolescents, ages 9-23, completed delay and probability discounting tasks and measures of verbal and nonverbal intelligence, executive functioning, and self-reported internalizing and externalizing behavior. Delay but not probability discounting decreased with age. Delay discounting was also associated with ver... | 18,978,926 |
Neural network approaches and their reproducibility in the study of verbal working memory and Alzheimer's disease. | As clinical and cognitive neurosciences mature, the need for sophisticated neuroimaging analysis becomes more apparent. Multivariate analysis techniques have recently received increasing attention because they have attractive features that cannot be easily realized by the more commonly used univariate, voxel-wise, tech... | 18,978,933 |
Of Asian forests and European fields: Eastern U.S. plant invasions in a global floristic context. | Biogeographic patterns of species invasions hold important clues to solving the recalcitrant 'who', 'where', and 'why' questions of invasion biology, but the few existing studies make no attempt to distinguish alien floras (all non-native occurrences) from invasive floras (rapidly spreading species of significant manag... | 18,978,940 |
Osteoclasts are active in bone forming metastases of prostate cancer patients. | Bone forming metastases are a common and disabling consequence of prostate cancer (CaP). The potential role of osteoclast activity in CaP bone metastases is not completely explained. In this study, we investigated ex vivo whether the osteolytic activity is present and how it is ruled in CaP patients with bone forming m... | 18,978,943 |
Squamous cell carcinoma of the external auditory canal. | This study aims to analyze the treatments, prognostic variables, and outcomes of patients with squamous cell carcinomas (SCC) of the external auditory canal (EAC) and middle ear treated in our department over a 15-year period. A retrospective analysis of 19 patients treated in our department between 1990 and 2006. The ... | 18,978,963 |
Intracranial enterogenous cyst extending into both supratentorial and infratentorial compartments: case report and review of the literature. | Intracranial enterogenous cysts are rare. There have been only two cases reported of such cysts that extended into both the infratentorial and supratentorial compartments. We add a third case and review the literature to assess their pathogenesis, clinical features, and management. | 18,978,968 |
Chemotactic response of marine micro-organisms to micro-scale nutrient layers. | The degree to which planktonic microbes can exploit microscale resource patches will have considerable implications for oceanic trophodynamics and biogeochemical flux. However, to take advantage of nutrient patches in the ocean, swimming microbes must overcome the influences of physical forces including molecular diffu... | 18,979,007 |
Injection of dsRNA into female A. aegypti mosquitos. | Reverse genetic approaches have proven extremely useful for determining which genes underly resistance to vector pathogens in mosquitoes. This video protocol illustrates a method used by the James lab to inject dsRNA into female A. aegypti mosquitoes, which harbor the dengue virus. The technique for calibrating injecti... | 18,979,015 |
Protocol for mosquito rearing (A. gambiae). | This protocol describes mosquito rearing in the insectary. The insectary rooms are maintained at 28 degrees C and approximately 80% humidity, with a 12 hr. day/night cycle. For this procedure, you'll need mosquito cages, 10% sterile sucrose solution, paper towels, beaker, whatman filter paper, glass feeders, human bloo... | 18,979,019 |
Predicting the effectiveness of population replacement strategy using mathematical modeling. | Charles Taylor and John Marshall explain the utility of mathematical modeling for evaluating the effectiveness of population replacement strategy. Insight is given into how computational models can provide information on the population dynamics of mosquitoes and the spread of transposable elements through A. gambiae su... | 18,979,025 |
Structure of lyotropic self-assembled lipid nonlamellar liquid crystals and their nanoparticles in mixtures of phosphatidyl choline and alpha-tocopherol (vitamin E). | The structural/phase behaviour of self-assembled lyotropic liquid crystals formed in mixtures of a phospholipid and alpha-tocopherol (vitamin E) is presented. | 18,979,032 |
Photo-degradation of yperite over V, Fe and Mn-doped titania-silica photocatalysts. | The photocatalytic decomposition of yperite (bis(2-chloroethyl)sulfide), a chemical warfare agent, was achieved by using titania-silica catalysts doped with several transition metal ions. The preparation of these catalysts was achieved by impregnation of a titania-silica mixed oxide previously synthesized using a sol-g... | 18,979,041 |
H-Bond interactions between silicates and water during zeolite pre-nucleation. | The relative strength of water-water, water-silicate and silicate-silicate interactions are studied, in order to explain the low solubility of the monomer (Si(OH)(4)), and determine the degree of dispersion of silicate clusters in solution during the hydrothermal synthesis of zeolites. We will show how the hydrogen bon... | 18,979,042 |
Contamination profiles of antifouling biocides in selected coastal regions of Malaysia. | The concentrations of butyltins (BTs) in sediment from Peninsular Malaysia along the Strait of Malacca and their spatial distribution are discussed. The concentrations of BTs were high in the southern part of Peninsular Malaysia where there is a lot of ship traffic, because trade is prosperous. The concentrations of mo... | 18,979,060 |
A case report of glomerulopathy-associated podocytic infolding in a patient with tumor lysis syndrome. | A 59-year-old man underwent total gastrectomy and splenectomy for gastric cancer 14 months before admission. The pathological diagnosis was neuroendocrine carcinoma of the stomach. Eight months after the operation, systemic chemotherapy with irinotecan and cisplatin was started because of multiple metastases to lymph n... | 18,979,061 |
Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer. | Numerous enzymes, including Cytochrome P450s (phase I) and Glutathione-S-transferases (phase II), are involved in the metabolic activation and detoxification of carcinogens. Epidemiological studies have consistently demonstrated that bladder cancer is strongly associated with cigarette smoking, and the risk for the dev... | 18,979,064 |
A "bad" case of Tako-Tsubo syndrome. | The prognosis of Tako-Tsubo syndrome (TTS) is believed to be favorable. In most of the cases, there is a complete recovery of left ventricular (LV) function and of symptoms, but previous cases have been described with low-output syndrome, deaths within the first 24 h from acute heart failure, and some deaths due to LV ... | 18,979,067 |
Regulator of G-protein signalling expression and function in ovarian cancer cell lines. | Regulator of G-protein signalling (RGS)(2) proteins critically regulate signalling cascades initiated by G-protein coupled receptors (GPCRs) by accelerating the deactivation of heterotrimeric G-proteins. Lysophosphatidic acid (LPA) is the predominant growth factor that drives the progression of ovarian cancer by activa... | 18,979,070 |
Endocytosis as a mechanism of regulating natural killer cell function: unique endocytic and trafficking pathway for CD94/NKG2A. | Natural killer (NK) cells are lymphocytes generally recognized as sentinels of the innate immune system due to their inherent capacity to deal with diseased (stressed) cells, including malignant and infected. This ability to recognize many potentially pathogenic situations is due to the expression of a diverse panel of... | 18,979,076 |
Protocols in expedited review: tackling the workload of ethics committees. | This paper describes the experience of the Ethics Committee of the Medical University of Vienna, Austria, while managing the workload of clinical study applications. An expedited review process was introduced for initial review of study protocols regarded as minimal risk interventions in March 2004. A total of 504 stud... | 18,979,085 |
TOO MANY MOUTHS promotes cell fate progression in stomatal development of Arabidopsis stems. | Mutations in TOO MANY MOUTHS (TMM), which encodes a receptor-like protein, cause stomatal patterning defects in Arabidopsis leaves but eliminate stomatal formation in stems. Stomatal development in wild-type and tmm stems was analyzed to define TMM function. Epidermal cells in young tmm stems underwent many asymmetric ... | 18,979,118 |
Bioremediation of nitroexplosive wastewater by an yeast isolate Pichia sydowiorum MCM Y-3 in fixed film bioreactor. | Nitroexplosives are essential for security and defense of the nation and hence their production continues. Their residues and transformed products, released in the environment are toxic to both terrestrial and aquatic life. This necessitates remediation of wastewaters containing such hazardous chemicals to reduce threa... | 18,979,124 |
Identification and characterization of Wolbachia in Solenopsis saevissima fire ants (Hymenoptera: Formicidae) in southeastern Brazil. | The genus Solenopsis appears to have evolved and radiated very rapidly in South America and then spread throughout the rest of the continent. As part of the expansion process, distribution patterns and different degrees of geographic isolation among populations of S. saevissima can be observed. We have investigated the... | 18,979,132 |
Postoperative infection and survival in osteosarcoma patients. | The clinical impact of postoperative deep infection on survival remains controversial in osteosarcoma patients. The authors identified 31 osteosarcoma patients that developed a deep infection within 1 year of operation between 1990 and 2003, and compared clinicopathologic characteristics of 31 patients that developed a... | 18,979,137 |
Expression and clinical significance of cell cycle regulatory proteins in gallbladder and extrahepatic bile duct cancer. | Disruption of cell cycle controls is a pathognomonic feature of all malignant cells. Therefore, we immunohistochemically investigated the relationship between cell cycle regulatory proteins and clinicopathologic features in order to identify the biomarkers related to the outcome of patients with biliary tract cancer (B... | 18,979,138 |
Improving patient understanding of prescription drug label instructions. | Patient misunderstanding of instructions on prescription drug labels is common and a likely cause of medication error and less effective treatment. To test whether the use of more explicit language to describe dose and frequency of use for prescribed drugs could improve comprehension, especially among patients with lim... | 18,979,142 |
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