title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Analysis and assessment on heavy metal sources in the coastal soils developed from alluvial deposits using multivariate statistical methods. | An investigation on heavy metal sources, i.e., Cu, Zn, Ni, Pb, Cr, and Cd in the coastal soils of Shanghai, China, was conducted using multivariate statistical methods (principal component analysis, clustering analysis, and correlation analysis). All the results of the multivariate analysis showed that: (i) Cu, Ni, Pb,... | 18,976,857 |
Epidemiology of invasive pneumococcal disease in the Arabian Peninsula and Egypt. | Invasive pneumococcal disease (IPD) causes considerable morbidity and mortality among children worldwide. This review describes the burden of disease and pneumococcal serotypes/serogroups causing disease in children in the Arabian Peninsula and Egypt identified from a literature search from 1990 to 2007. The incidence ... | 18,976,887 |
Do we still need the aminoglycosides? | Since the introduction into clinical practice of the aminoglycoside class of antibiotics, a number of other antimicrobial agents with improved safety profile have entered the market. Studies have failed to demonstrate the superiority of aminoglycoside-containing regimens in a number of infection settings. This has rais... | 18,976,888 |
Genotype-phenotype correlations in ACTA1 mutations that cause congenital myopathies. | Mutations in the skeletal muscle actin gene, ACTA1 are responsible for up to 20% of congenital myopathies with a variety of pathologies that includes nemaline myopathy, intranuclear rod myopathy, actin myopathy and congenital fibre type disproportion. In their review of 2003, Sparrow et al. considered how these actin m... | 18,976,909 |
Selective detection of specific protein-ligand complexes by electrosonic spray-precursor ion scan tandem mass spectrometry. | A novel mass spectrometric method for the selective detection of specific protein-ligand complexes is presented. The new method is based on electrosonic spray ionization of samples containing protein and ligand molecules, and mass spectrometric detection using the precursor ion scanning function on a triple quadrupole ... | 18,976,932 |
Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation. | SWAP-70-like adaptor of T cells (SLAT) is a guanine nucleotide exchange factor for Rho GTPases that regulates the development of T helper 1 (Th1) and Th2 cell inflammatory responses by controlling the Ca(2+)-NFAT signaling pathway. However, the mechanism used by SLAT to regulate these events is unknown. Here, we report... | 18,976,935 |
The effect of 1alpha,25(OH)2D3 vitamin over oxidative stress and biochemical parameters in rats where Type 1 diabetes is formed by streptozotocin. | The 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] plays an essential role in mineral balance but has also been recognized as a powerful modulator of immune response. We aimed to examine the effect of the 1alpha,25(OH)(2)D(3) treatment on insulin/c-peptide, catalase, superoxide dismutase (SOD), and blood glucos... | 18,976,933 |
Resonance Rayleigh scattering spectra, non-linear scattering spectra of tetracaine hydrochloride-erythrosin system and its analytical application. | The interaction between erythrosine (ET) and tetracaine hydrochloride (TA) was studied by resonance Rayleigh scattering (RRS), frequency doubling scattering (FDS) and second-order scattering (SOS) combining with absorption spectrum. In a weak acidic medium of Britton-Robinson (BR) buffer solution of pH 4.5, erythrosine... | 18,976,950 |
Managing the femoral artery in coronary angiography. | Vascular access and subsequent methods to obtain haemostasis are commonly overlooked components of coronary angiography, yet most complications related to diagnostic coronary angiography and percutaneous coronary interventions come from groin bleeds. Most of these complications are minor, leading to bruising and patien... | 18,976,958 |
Treatment-emergent endocrine symptoms and the risk of breast cancer recurrence: a retrospective analysis of the ATAC trial. | When the mechanism of action behind treatment toxicity reflects the intended effect on the treatment target, the toxicity might be a useful marker for efficacy. During endocrine treatment of breast cancer, the occurrence of symptoms related to oestrogen depletion or oestrogen blockade might thus be a predictor of treat... | 18,976,959 |
A single-blind, placebo run-in study of duloxetine for activity-limiting osteoarthritis pain. | Osteoarthritis pain is a significant problem for our aging population. Antidepressants that are serotonin-norepinephrine reuptake inhibitors are effective for other forms of chronic pain and may provide a new treatment option for osteoarthritis pain. We performed a single-blind, placebo run-in trial of 60 to 90 mg of d... | 18,976,962 |
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice. | Hyperbaric oxygen (HBO(2)) therapy is reported to cause pain relief in several conditions of chronic pain. A single 60-minute session of HBO(2) treatment produced a prolonged antinociceptive effect in mice that persisted for 90 minutes after cessation of treatment. The HBO(2)-induced antinociception was significantly a... | 18,976,963 |
Modelling of mandibular movement. | In this paper, the authors presented a novel method to reconstruct individual mandible movement in three dimensions by a virtual articulator system. The system provides a synchronized 3D mandibular movement that faithfully reappear one's natural occlusion movements--sagittal border, lateral, and open-close movements. M... | 18,976,989 |
Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography. Comparison of various elution and operating strategies. | This paper describes how high-performance counter-current chromatography (HPCCC) was used strategically for the separation of Tripterygium wilfordii Hook. f. Due to the complexity of Chinese herbal medicines, the initial ethanol crude extract was fractionated into seven fractions using medium-pressure liquid chromatogr... | 18,976,997 |
Oxidation of volatile organic compounds on SBA-15 mesoporous molecular sieves modified with manganese. | Catalytic combustion of volatile organic compounds, such as propene, has been studied on manganese modified mesoporous molecular sieves. Powder X-ray diffraction, (29)Si nuclear magnetic resonance, nitrogen sorption and transmission electron microscopy show that the SBA-15 mesoporous silica molecular sieve can be modif... | 18,977,012 |
Salivary cortisol in unaffected twins discordant for affective disorder. | Dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as a biological endophenotype for affective disorders. In the present study the hypothesis that a high genetic liability to affective disorder is associated with higher cortisol levels was tested in a cross-sectional high-risk study. Healthy... | 18,977,033 |
Impact of stress and mast cells on brain metastases. | Metastases continue to be the chief cause of morbidity and mortality for many tumors, including brain metastases of lung and mammary adenocarcinoma. Stress appears to increase metastases, but the mechanism is not understood. Recent evidence suggests that local inflammation is conducive for cancer growth and a unique im... | 18,977,036 |
PrP antibody binding-induced epitope modulation evokes immunocooperativity. | We have characterized the antibody-antigen binding events of the prion protein (PrP) utilizing three new PrP-specific monoclonal antibodies (Mabs). The degree of immunoreactivity was dependent on the denaturation treatment with the combination of heat and SDS resulting in the highest levels of epitope accessibility and... | 18,977,037 |
Osteoporosis and congestive heart failure (CHF) in the elderly patient: double disease burden. | The present study aimed to evaluate the association between osteoporosis and CHF in elderly patients and to assess the effect of physical performance, vitamin D levels, inflammatory markers on this association. One hundred and twenty-six consecutive patients aged 65 years and above, with moderate to severe CHF who pres... | 18,977,041 |
Engineering microbes with synthetic biology frameworks. | Typically, the outcome of biologically engineered unit operations cannot be controlled a priori due to the incorporation of ad hoc design into complex natural systems. To mitigate this problem, synthetic biology presents a systematic approach to standardizing biological components for the purpose of increasing their pr... | 18,977,048 |
Is the crime drop of the 1990s in Canada and the USA associated with a general decline in risky and health-related behavior? | Crime rates dropped unexpectedly and dramatically in the 1990s in Canada and the USA. The decline was not restricted to particular types of crime, the particular methodologies of crime reports, demographic characteristics, or geographical areas. Psychological studies of individuals have suggested a link between crime a... | 18,977,063 |
Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial. | To determine the efficacy of motexafin gadolinium (MGd) in combination with whole brain radiotherapy (WBRT) for the treatment of brain metastases from non-small-cell lung cancer. In an international, randomized, Phase III study, patients with brain metastases from non-small-cell lung cancer were randomized to WBRT with... | 18,977,094 |
Dose-response relationship for image-guided stereotactic body radiotherapy of pulmonary tumors: relevance of 4D dose calculation. | To evaluate outcome after image-guided stereotactic body radiotherapy (SBRT) for early-stage non-small-cell lung cancer (NSCLC) and pulmonary metastases. A total of 124 patients with 159 pulmonary lesions (metastases n = 118; NSCLC, n = 41; Stage IA, n = 13; Stage IB, n = 19; T3N0, n = 9) were treated with SBRT. Patien... | 18,977,095 |
Implanted cardiac defibrillator care in radiation oncology patient population. | To review the experience of a large cancer center with radiotherapy (RT) patients bearing implantable cardiac defibrillators (ICDs) to propose some preliminary care guidelines as we learn more about the devices and their interaction with the therapeutic radiation environment. We collected data on patients with implante... | 18,977,096 |
Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection. | A reverse phase high performance liquid chromatographic (HPLC) method with evaporative light scattering detection (ELSD) was developed for simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae. The analysis was performed by gradient elution, using an aqueous mobile phase (containing... | 18,977,107 |
Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa. | Excessive physical activity is commonly described as symptom of Anorexia Nervosa (AN). Activity-based anorexia (ABA) is considered an animal model for AN. The ABA model mimics severe body weight loss and increased physical activity. Suppression of hyperactivity by olanzapine in anorectic patients as well as in ABA rats... | 18,977,121 |
Risk assessment of pneumothorax and pulmonary haemorrhage complicating percutaneous co-axial cutting needle lung biopsy. | The primary aim of this study was to evaluate the ability of radiologists to accurately estimate pneumothorax and pulmonary haemorrhage during percutaneous co-axial cutting needle CT-guided lung biopsy. Patients undergoing cutting needle lung biopsy during the study period were identified; the path taken by the cutting... | 18,977,128 |
Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. | For decades, low doses of antibiotics have been used widely in animal production to promote growth. However, there is a trend to reduce this use of antibiotics in feedstuffs, and legislation is now in place in Europe to prohibit their use in this way. As a consequence, economically important diseases, such as necrotic ... | 18,977,143 |
Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats. | Diabetes mellitus is the leading cause of peripheral neuropathy worldwide. Despite this high level of incidence, underlying mechanisms of the development and maintenance of neuropathic pain are still poorly understood. Evidence supports a prominent role of glial cells in neuropathic pain states. Gabapentin is used clin... | 18,977,160 |
NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. | The limitations of current treatments for postherpetic neuralgia (PHN) have led to the investigation of localised, non-systemic alternatives. NGX-4010, a high-concentration (8%) capsaicin dermal patch, was developed to treat patients with neuropathic pain. We report the results of a randomised, double blind, 12-week st... | 18,977,178 |
Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: a proteomic approach. | Clinical proteomics has been widely used to identify differentially displayed proteins in blood and cerebrospinal fluid (CSF) to understand the molecular and cellular events leading to Parkinson's disease (PD). The close connection between CSF and the brain offers reliable and reproducible way to assess the majority of... | 18,977,210 |
3-D measurement of osmotic dehydration of isolated and adhered PC-3 cells. | Cell dehydration during freezing results from an elevated concentration of electrolytes in the extracellular medium that is deeply involved in cellular injury. We undertook real-time threedimensional (3-D) observation of osmotic dehydration of cells, motivated by a comparison of cellular responses between isolated cell... | 18,977,212 |
Functional characterisation of hemokinin-1 in mouse uterus. | The preprotachykinin gene Tac4 expressed in murine uterus and placenta is thought to encode a peptide RSRTRQFYGLM-NH(2), mouse hemokinin 1. We have examined the uterotonic effects of mouse hemokinin 1 and its N-terminally truncated analogue, mouse hemokinin 1(2-11) on mouse uterus. Mouse hemokinin 1(2-11) was equieffec... | 18,977,217 |
Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury. | A prospective, multicenter, randomized trial did not demonstrate improved outcomes in severe traumatic brain injured patients treated with mild hypothermia [Clifton, G.L., Miller, E.R., Choi, S.C., Levin, H.S., McCauley, S., Smith, K.R., Jr., Muizelaar, J.P., Wagner, F.C., Jr., Marion, D.W., Luerssen, T.G., Chesnut, R.... | 18,977,220 |
Autonomic and cardiovascular effects of central neuromedin U in rats. | Previous studies have demonstrated that neuromedin U (NMU) affects cardiovascular functions such as blood pressure (BP) or heart rate (HR) in rats. Here, we examined the effects of the lateral cerebral ventricular (ICV) injection of various doses of NMU on renal sympathetic nerve activity (RSNA) and BP in urethane-anes... | 18,977,236 |
A tailored Internet-plus-email intervention for increasing physical activity among ethnically-diverse women. | To evaluate the feasibility and efficacy of an individually tailored, Internet-plus-email physical activity intervention designed for adult women. Healthy and ethnically-diverse adult females (N=156) (mean age=42.8 years, 65% Caucasian) from California were randomly assigned to an intervention (access to a tailored web... | 18,977,243 |
Does senescence give rise to disease? | The distinctions between senescence and disease are blurred in the literature of evolutionary biology, biodemography, biogerontology and medicine. Theories of senescence that have emerged over the past several decades are based on the concepts that organisms are a byproduct of imperfect structural designs built with im... | 18,977,242 |
Assessing time-dependent association between scalp EEG and muscle activation: A functional random-effects model approach. | This study investigates time-dependent associations between source strength estimated from high-density scalp electroencephalogram (EEG) and force of voluntary handgrip contraction at different intensity levels. We first estimate source strength from raw EEG signals collected during voluntary muscle contractions at dif... | 18,977,246 |
Is GPR39 the natural receptor of obestatin? | GPR39, an orphan receptor belonging to the family of G protein-coupled receptors, was originally reported to be the receptor of obestatin. However recently, numerous reports have questioned this conclusion. In mammals, GPR39 was reported to be involved in the regulation of gastrointestinal and the metabolic functions. ... | 18,977,259 |
Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. | In this study, we identified, using an established oligonucleotide microarray platform for the parasitic nematode Haemonchus contortus, transcripts that are 'conserved' between serum-activated and non-activated L3s of Ancylostoma caninum (aL3 and L3, respectively) and H. contortus by cross-species hybridization (CSH) a... | 18,977,290 |
Labyrinthulomycetes phylogeny and its implications for the evolutionary loss of chloroplasts and gain of ectoplasmic gliding. | The labyrinthulomycetes, also known as the 'Labyrinthulomycota' are saprotrophic or less frequently parasitic stramenopilan protists, usually in marine ecosystems. Their distinguishing feature is an 'ectoplasmic net,' an external cytoplasmic network secreted by a specialized organelle that attaches the cell to its subs... | 18,977,305 |
Do informed consent documents matter? | This commentary argues that, despite extensive critiques of informed consent documents, there are several ethical and legal reasons for investigators and IRB members to take these documents seriously. | 18,977,313 |
Regulating the conversion between rounded and elongated modes of cancer cell movement. | Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to varying microenvironments. In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac and Rho signaling that determine the mode of movement driving melanoma cel... | 18,977,323 |
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. | A key step in angiogenesis is the upregulation of growth factor receptors on endothelial cells. Here, we demonstrate that a small regulatory microRNA, miR-296, has a major role in this process. Glioma cells and angiogenic growth factors elevate the level of miR-296 in primary human brain microvascular endothelial cells... | 18,977,327 |
Identification of novel mutations in five patients with mitochondrial encephalomyopathy. | MELAS, MERRF, LHON and NARP, are well-established mitochondrial syndromes associated with specific point mutations of mitochondrial DNA (mtDNA). However, these recurrent mtDNA mutations account for only a minority of mitochondrial disease cases. To evaluate the impact of novel mtDNA mutations, we performed mtDNA sequen... | 18,977,334 |
Suprachiasmatic nucleus slices induce molecular oscillations in fibroblasts. | The mammalian circadian pacemaker has been localized to the hypothalamic suprachiasmatic nucleus (SCN), where a set of clock genes and their resulting proteins form interlocking transcriptional/translational feedback loops to sustain molecular and functional oscillations. Interestingly, peripheral tissues and stimulate... | 18,977,335 |
Visual evoked spread spectrum analysis (VESPA) responses to stimuli biased towards magnocellular and parvocellular pathways. | Stimulus contrast fluctuations were controlled while the properties of a novel ERP known as the VESPA (Visual Evoked Spread Spectrum Analysis) were examined using data from 8 healthy human subjects. Substantial differences were seen between the morphologies of VESPAs obtained using low contrast stimuli when compared wi... | 18,977,382 |
Minocycline and neurodegenerative diseases. | Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively crossing the blood-brain barrier, effective against gram-positive and -negative infections. In addition to its own antimicrobacterial properties, minocycline has been reported to exert neuroprotective effects over various experi... | 18,977,395 |
A new polysaccharide from leaf of Ginkgo biloba L. | A water-soluble polysaccharide, GPB, was obtained from leaf of Ginkgo biloba L by hot water extraction followed by precipitation with ethanol and fractionation with gel chromatography. The results of HPLC with TSK-GEL column and gel filtration chromatography with Sepharose CL-6B analysis indicated GPB was uniform in po... | 18,977,417 |
Feature-short and feature-long discrimination learning in the pigeon: conditional control of a two-event temporal map. | Eight pigeons were trained to peck an illuminated target key on discrete-trial fixed-interval schedules of reinforcement by food. Four birds were exposed to a feature-short (FS) task where a feature light signaled shortening of the forthcoming target-outcome interval from 30 to 15s, while the other four birds were expo... | 18,977,418 |
Phylogenetic conservation of cytostatic factor related genes in the ascidian Ciona intestinalis. | In all vertebrates, mature oocytes arrest at the metaphase of the II meiotic division, while some invertebrates arrest at metaphase-I, others at prophase-I. Fertilization induces completion of meiosis and entry into the first mitotic division. Several experimental models have been considered from both vertebrates and i... | 18,977,421 |
Effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis. | The aim of the study was to investigate the effects of TGP, an active compound extracted from the roots of Paeonia lactiflora Pall, on the activities of synoviocytes in rats with collagen-induced arthritis (CIA) and its possible mechanisms. CIA was induced in male Sprague-Dawley (SD) rats immunized with chicken type II... | 18,977,427 |
Aedes FADD: a novel death domain-containing protein required for antibacterial immunity in the yellow fever mosquito, Aedes aegypti. | Microbial infections in insects activate a series of immune responses that culminate in the production of antimicrobial peptides (AMPs). In Drosophila, two signaling pathways, govern the challenge-dependent expression of AMPs; the Toll and IMD pathways. While AMPs have been the subject of much research in mosquitoes, t... | 18,977,438 |
Molecular analysis of the Aedes aegypti carboxypeptidase gene family. | To gain a better understanding of coordinate regulation of protease gene expression in the mosquito midgut, we undertook a comprehensive molecular study of digestive carboxypeptidases in Aedes aegypti. Through a combination of cDNA cloning using degenerate PCR primers, and database mining of the recently completed A. a... | 18,977,440 |
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products. | Upon primary infection, EBV establishes a latent infection in B cells, characterized by maintenance of the viral genome in the absence of viral replication. The Epstein-Barr Nuclear Antigen 1 (EBNA1) plays a crucial role in maintenance of the viral DNA episome and is consistently expressed in all EBV-associated maligna... | 18,977,445 |
The role of electron transport in the defence response of the South African abalone, Haliotis midae. | In order to establish health management systems for farmed abalone, it is necessary to understand how the abalone immune system functions and responds to stimulation. Two electron transport system genes, cytochrome b and cytochrome c oxidase III, were found to be upregulated in a cDNA microarray experiment performed on... | 18,977,446 |
The Val432Leu polymorphism of the CYP1B1 gene is associated with differences in estrogen metabolism and bone density. | Polymorphisms of the CYP450 genes that encode for the enzymes that metabolize estrogen are linked to hormone-related cancers. We investigated the impact of two polymorphisms of the CYP1B1 gene previously reported to be associated with hormone-related disorders on estrogen metabolism and bone mineral density (BMD), anot... | 18,977,467 |
Self-defining memories in complicated grief. | There is increasing attention to the mechanisms underpinning maladaptive responses to bereavement. This study indexed self-defining memories in bereaved individuals with and without complicated grief (CG). Participants with and without complicated grief (N=40) were asked to describe three self-defining memories. Result... | 18,977,471 |
Formation and structure elucidation of N-(2,3,4-tri-O-acetyl-beta-D-glucopyranosyl)-N'-acetylthiourea. | Treatment with concd HCl/MeOH transformed N-(tetra-O-acetyl-beta-D-glucopyranosyl)-N'-acetylthiourea, via selective cleavage of the primary alcoholic ester group, into the title compound. | 18,977,474 |
Concentration determination of oxygen nanobubbles in electrolyzed water. | Water electrolysis is well known to produce solutions supersaturated with oxygen. The oxygen in electrolyzed solutions was analyzed with a dissolved oxygen meter and the Winkler method of chemical analysis. The concentration of oxygen measured with the dissolved oxygen meter agreed with that obtained using the Winkler ... | 18,977,493 |
Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus. | Suitable animal models are needed to study monkeypox virus (MPXV) as human monkeypox clinically resembles smallpox and MPXV is a zoonotic and potential bioterroristic agent. We have demonstrated that a species of African dormice, Graphiurus kelleni, is susceptible to a lethal infection of MPXV and that MPXV replicated ... | 18,977,501 |
Leaching of brominated flame retardants from TV housing plastics in the presence of dissolved humic matter. | In this study, we investigated the contents of several brominated compounds in TV molding plastics, as well as their leaching characteristics in the presence of DHM. The PBDE content was about 3% of the sample weight, and deca-BDE was the most abundant homologue, accounting for over 80% of the total amount. TBBPA, PBPs... | 18,977,511 |
Shifting the bell curve: the benefits and costs of raising student achievement. | Benefit-cost analysis was conducted to estimate the increase in earnings, increased tax revenues, value of less crime, and reductions in welfare costs attributable to nationwide implementation of rapid assessment, a promising intervention for raising student achievement in math and reading. Results suggest that social ... | 18,977,534 |
Protein kinase C-beta inhibition for diabetic kidney disease. | Amid the rapidly rising number of people with diabetes worldwide, the prevalence of diabetic kidney disease (DKD) is expected to increase considerably despite available treatments. Consequently, novel therapeutic agents are urgently needed. Ruboxistaurin mesylate is a bisindolylmaleimide that specifically inhibits the ... | 18,977,550 |
Ozone and urban forests in Italy. | Ozone levels along urban-to-rural gradients in three Italian cities (Milan, Florence, Bari) showed that average AOT40 values at rural and suburban sites were 2.6 times higher than those determined at urban sites. However, O(3) also exceeded the European criteria to protect forest health at urban sites, even when the st... | 18,977,568 |
Background ozone in the southern Europe and Mediterranean area: influence of the transport processes. | The troposphere is subject to continuous inputs, production and removal processes of ozone and its precursors from natural processes and human activities acting together within a very complex system. In order to assess the behaviour of background ozone in the Mediterranean area, a description of trends, seasonal and di... | 18,977,575 |
Who is hurt by procyclical mortality? | There is renewed interest in understanding how fluctuations in mortality and in health are related to fluctuations in economic conditions. The traditional perspective that economic recessions lower health and raise mortality has been challenged by recent findings that reveal mortality is actually procyclical. The epide... | 18,977,577 |
Complications of anterior surgery in cervical spine trauma: an overview. | Although anterior surgery for cervical spine injuries is a widespread procedure, articles regarding its overall complications are infrequently published in the literature. In the current study we focus on the complications encountered after anterior instrumented stabilization of cervical spine injuries and we discuss w... | 18,977,582 |
Blood flow velocity in the arteries of the anterior cerebral artery complex in patients with an azygos anterior cerebral artery aneurysm: a transcranial color-coded sonography study. | It is presumed that increased blood flow through the single azygos anterior cerebral artery (Az) may contribute to the formation of an Az aneurysm. The aim of this study was to assess the blood flow velocities in the arteries of the anterior cerebral artery (ACA) complex in patients with the Az aneurysm. A series of th... | 18,977,588 |
Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells. | The green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), inhibits the development and progression of prostate cancer in TRAMP mice and in men. We examined the effects of EGCG on LNCaP human prostate cancer sublines 104-S, 104-R1 and R1Ad representing different progression stages of prostate cancer. EGCG suppres... | 18,977,589 |
Hydrogeochemistry and arsenic contamination of groundwater in the Ganges Delta Plain, Bangladesh. | Geochemical composition and the level of Arsenic (As) contamination of groundwater in the Ganges Delta Plain, southwestern Bangladesh were elucidated. Hydrogeochemical data of tube well samples suggested that the groundwater is mostly Ca-Mg-HCO(3) type with bicarbonate (HCO(3)(-)) as the dominant anion, though other ty... | 18,977,593 |
Studies on Neospora caninum DNA detection in the oocytes and embryos collected from infected cows. | Neosporosis is a major cause of abortion in cattle over the world. One of the methods of preventing vertical transmission within the herd is to avoid breeding replacement heifers from infected dams. Another procedure suggested and recommended by the International Embryo Transfer Society (IETS) is embryo transfer (ET) f... | 18,977,601 |
Periparturient use of parenteral micronised procaine penicillin to reduce the risk of clinical mastitis in heifers after calving. | Mastitis in primiparous heifers immediately postpartum can be both a significant welfare concern and a heavy economic loss. Interventions successfully researched include intramammary therapies. This study considered the clinical and practical effects of a parenteral approach to controlling clinical mastitis in heifers ... | 18,977,612 |
Reversal sign on ante- and postmortem brain imaging in a newborn: report of one case. | A 16-day-old female newborn was admitted to the emergency department after cardiopulmonary arrest. Total-body radiographs and non-enhanced CT of the brain showed fracture of the right clavicle, pericerebral hemorrhage and brain damage with reversal sign. The infant died on the day of her hospital admission. Because chi... | 18,977,623 |
[Depression and pain: prevalence and clinical implication]. | Somatic pains are frequent in patients with major depression. Although they are not included in classical symptoms of depression, physical pains are found in 50-90% of depressed patient. They are more frequent in severe depressions, and especially in psychiatric inpatients with depression. Physical painful symptoms are... | 18,977,630 |
Primary total hip arthroplasty in severe developmental dysplasia of the hip. Ten-year results using a cementless modular stem. | We report the average 10-year clinical and radiographic results of 28 hips with Crowe III or IV developmental dysplasia of the hip (DDH) and a technically difficult primary hip arthroplasty using the cementless modular S-ROM stem (DePuy Orthopedics, Warsaw, Ind). Twenty-one patients required significant autologous bone... | 18,977,633 |
Long-term remodeling in proximal femur around a hydroxyapatite-coated anatomic stem: ten years densitometric follow-up. | Bone remodeling after a hip arthroplasty has been quantified with dual energy x-ray absorptiometry, usually for short-term follow-up. We used this technique to determine the long-term remodeling produced by a hydroxyapatite-coated, anatomic stem. Eighty patients with unilateral hip osteoarthritis were included in the s... | 18,977,634 |
[Chronic daily headache in children and adolescents]. | Chronic daily headache (CDH) affects 2-4% of adolescent females and 0.8-2% of adolescent males. Chronic daily headache is diagnosed when headaches occur more than 4h/day, 15 headache days per month or more, over a period of 3 consecutive months, without an underlying pathology. It is manifested by severe intermittent, ... | 18,977,644 |
Fabrication of a highly sensitive penicillin sensor based on charge transfer techniques. | A highly sensitive penicillin biosensor based on a charge-transfer technique (CTTPS) has been fabricated and demonstrated in this paper. CTTPS comprised a charge accumulation technique for penicilloic acid and H(+) ions perception system. With the proposed CTTPS, it is possible to amplify the sensing signals without ex... | 18,977,651 |
Gene expression predictors in breast cancer: current status, limitations and perspectives. | Breast cancer is characterised by a wide heterogeneity regarding outcome and drug sensitivity. A better prediction of these two parameters at the individual level should improve patient management and therefore also improve both the quality of life and the overall survival of the patient. Several molecular predictors f... | 18,977,656 |
Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel. | A highly efficient kinetic resolution of racemic cis-4-(2-tert-butyldimethylsilyloxy-1,1-dimethyl)ethyl-3-tert-butyldimethylsilyloxy-azetidin-2-one with 7-O-triethylsilylbaccatin III was carried out to furnish 10-O-acetyl-5'-hydroxybutitaxel after removal of the silyl protecting groups. The compound was 50% as active a... | 18,977,659 |
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues. | We report the synthesis of (2E,5E)-4-oxoheptadienedioic acid and (2E)-4-oxoheptenedioic acid and evaluation of both diester and diacid analogues as inhibitors of bacterial dihydrodipicolinate synthase. Enzyme kinetic studies allowed the determination of second-order rate constants of inactivation; and substrate co-incu... | 18,977,662 |
Cholangiocarcinoma. | Cholangiocarcinoma is an uncommon adenocarcinoma with poor prognosis. Although the 1-year survival has increased over time, the 5-year survival has not shown any significant change (less than 5%). Cure can only be expected from surgical resection of early stage tumours but most patients initially present with advanced ... | 18,977,670 |
Surveillance of antibiotic resistance evolution and detection of class 1 and 2 integrons in human isolates of multi-resistant Salmonella Typhimurium obtained in Uruguay between 1976 and 2000. | To study the evolution of antibiotic resistance in isolates of Salmonella enterica subspecies enterica serovar Typhimurium (Salmonella Typhimurium) obtained in Uruguay between the years 1976 and 2000, and to determine the incidence of class 1 and 2 integrons in the multi-resistant isolates. We studied 258 strains of Sa... | 18,977,678 |
Spectrofluorimetric determination of fluoroquinolones in pharmaceutical preparations. | Simple, rapid and highly sensitive spectrofluorimetric method is presented for the determination of four fluoroquinolone (FQ) drugs, ciprofloxacin, enoxacin, norfloxacin and moxifloxacin in pharmaceutical preparations. Proposed method is based on the derivatization of FQ with 4-chloro-7-nitrobenzofurazan (NBD-Cl) in bo... | 18,977,686 |
Detection of viral RNA from paraffin-embedded tissues after prolonged formalin fixation. | Isolating amplifiable RNA from formalin-fixed, paraffin-embedded (FFPE) tissues is more difficult than isolating DNA because of RNases, chemical modification of the RNA, and cross-linking of nucleic acids and proteins. Tissues containing infectious disease agents that require biosafety level (BSL)-3 and -4 necessitate ... | 18,977,691 |
Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. | In this study, acute and chronic brain and spinal cord lesions, and normal appearing white matter (NAWM), were resected post-mortem from a patient with aggressive relapsing-remitting multiple sclerosis (MS). T-cell infiltrates from the central nervous system (CNS) lesions and NAWM were separated and characterized in-vi... | 18,977,698 |
Monitoring medication adherence by unannounced pill counts conducted by telephone: reliability and criterion-related validity. | Although demonstrated valid for monitoring medication adherence, unannounced pill counts conducted in patients' homes are costly and logistically challenging. Telephone-based unannounced pill counts offer a promising adaptation that resolves most of the limitations of home-based pill counting. We tested the reliability... | 18,977,718 |
Low rate of adverse hepatic events associated with fosamprenavir/ritonavir-based antiretroviral regimens. | To appraise the incidence of liver toxicity in a population of patients receiving fosamprenavir/ritonavir (FPV/r) with a high frequency of viral hepatitis co-infection. 636 patients, 341 (54%) with HCV antibodies and 38 (5.6%) bearing serum HBsAg, were recruited. All of them received FPV/r 700/100 twice every day. 93 (... | 18,977,719 |
Redox proteomics: basic principles and future perspectives for the detection of protein oxidation in plants. | The production and scavenging of chemically reactive species, such as ROS/RNS, are central to a broad range of biotic and abiotic stress and physiological responses in plants. Among the techniques developed for the identification of oxidative stress-induced modifications on proteins, the so-called 'redox proteome', pro... | 18,977,746 |
Photosynthetic properties of C4 plants growing in an African savanna/wetland mosaic. | Photosynthesis rates and photosynthesis-leaf nutrient relationships were analysed in nine tropical grass and sedge species growing in three different ecosystems: a rain-fed grassland, a seasonal floodplain, and a permanent swamp, located along a hydrological gradient in the Okavango Delta, Botswana. These investigation... | 18,977,748 |
Extracellular ATP-induced NO production and its dependence on membrane Ca2+ flux in Salvia miltiorrhiza hairy roots. | Extracellular ATP (eATP) is a novel signalling agent, and nitric oxide (NO) is a well-established signal molecule with diverse functions in plant growth and development. This study characterizes NO production induced by exogenous ATP and examines its relationship with other important signalling agents, Ca(2+) and H(2)O... | 18,977,749 |
Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc. | The eukaryotic translation initiation factor (eIF) 4B promotes the RNA-dependent ATP hydrolysis activity and ATP-dependent RNA helicase activity of eIF4A and eIF4F during translation initiation. eIF4B also helps to organize the assembly of the translational machinery through its interactions with eIF4A, eIF4G, eIF3, th... | 18,977,752 |
Patients' preferences within randomised trials: systematic review and patient level meta-analysis. | To systematically review fully randomised patient preference trials and to explore the impact of preferences on attrition and outcome by meta-analysis of patient level data. Citation search using Science Citation Index and Google Scholar and search of the main electronic databases (Medline, CINAHL, Embase, and AMED) wi... | 18,977,792 |
Radial artery anomaly and its influence on transradial coronary procedural outcome. | The transradial approach for percutaneous coronary procedures has the advantage of reduced access site complications but is associated with specific technical challenges in comparison with the transfemoral approach. Transradial procedure failures can sometimes be due to variation in radial artery anatomy. However, data... | 18,977,799 |
Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. | In the general population, folic acid supplementation during pregnancy has been demonstrated to reduce the frequency of neural tube defects (NTDs) and other major congenital malformations (MCMs). It is recommended that women with epilepsy contemplating pregnancy take supplemental folic acid because of the known antifol... | 18,977,812 |
Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease. | Sporadic Alzheimer disease (AD) is a multifactorial disease to which both genetic and environmental factors contribute. Therefore, twin pairs are useful in studying its pathogenesis and aetiology. Cerebral glucose metabolism has been found to be reduced in AD patients. Cerebral glucose metabolism was studied in seven m... | 18,977,818 |
Neurological morbidity among human T-lymphotropic-virus-type-1-infected individuals in a rural West African population. | Community-based neurological data about human T lymphotropic virus type 1 (HTLV-1) morbidity in sub-Saharan Africa are scarce. To ascertain the prevalence of neurological morbidity, in particular tropical spastic paraparesis (TSP), among HTLV-1-infected subjects and to compare TSP prevalence in HTLV-1-infected with tha... | 18,977,823 |
Plasma vitamin B12 status and cerebral white-matter lesions. | Elevated homocysteine has been associated with a higher prevalence of cerebral white-matter lesions and infarcts, and worse cognitive performance. This raises the question whether factors involved in homocysteine metabolism, such as vitamin B(12), are also related to these outcomes. This study examined the association ... | 18,977,824 |
Hospital discharge of the high-risk neonate. | This policy statement updates the guidelines on discharge of the high-risk neonate first published by the American Academy of Pediatrics in 1998. As with the earlier document, this statement is based, insofar as possible, on published, scientifically derived information. This updated statement incorporates new knowledg... | 18,977,994 |
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