title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Presumed primary muscular lymphoma in a dog. | A case of presumed primary muscular lymphoma in an 8-year-old, intact, male Newfoundland dog is reported. The dog was presented for evaluation of an infiltrating ventral cervical mass, respiratory distress, and anorexia of 1-month duration. Fine-needle aspiration of the mass revealed anaplastic large cell lymphoma. Des... | 18,987,239 |
Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage. | Although trauma-hemorrhage (T-H) induces suppressed splenic dendritic cell (DC) maturation and antigen presentation capacity, it remains unclear whether IL-15 modulates splenic DC functions. The aim of this study therefore was to investigate the effect of IL-15 on splenic DC functions after T-H. Male C3H/HeN mice (6-8 ... | 18,987,248 |
Unveiling the bovine embryo transcriptome during the maternal-to-embryonic transition. | Bovine early embryos are transcriptionally inactive and subsist through the initial developmental stages by the consumption of the maternal supplies provided by the oocyte until its own genome activation. In bovine, the activation of transcription occurs during the 8- to 16-cell stages and is associated with a phase ca... | 18,987,256 |
Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice. | Transgenic (Tg) mice expressing approximately 95% of the D166V (aspartic acid to valine) mutation in the ventricular myosin regulatory light chain (RLC) shown to cause a malignant familial hypertrophic cardiomyopathy (FHC) phenotype were generated, and the skinned and intact papillary muscle fibers from the Tg-D166V mi... | 18,987,303 |
Transformation mechanism of amorphous calcium carbonate into calcite in the sea urchin larval spicule. | Sea urchin larval spicules transform amorphous calcium carbonate (ACC) into calcite single crystals. The mechanism of transformation is enigmatic: the transforming spicule displays both amorphous and crystalline properties, with no defined crystallization front. Here, we use X-ray photoelectron emission spectromicrosco... | 18,987,314 |
Direct demonstration of the cross-bridge recovery stroke in muscle thick filaments in aqueous solution by using the hydration chamber. | Despite >50 years of research work since the discovery of sliding filament mechanism in muscle contraction, structural details of the coupling of cyclic cross-bridge movement to ATP hydrolysis are not yet fully understood. An example would be whether lever arm tilting on the myosin filament backbone will occur in th... | 18,987,316 |
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. | Glycopeptide antibiotics have long served as drugs of last resort for the treatment of antibiotic-resistant gram-positive bacterial infections. Resistance to the clinically relevant glycopeptides, vancomycin and teicoplanin, threatens to undermine the usefulness of this important class of antibiotics. DNA extracted fro... | 18,987,322 |
A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis. | Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with complicated pathogenesis that poses challenges with respect to diagnosis and monitoring of disease progression. To identify a biomarker panel that elucidates ALS disease pathogenesis, distinguishes patients with ALS from neurologic dise... | 18,987,350 |
Novel functions of the CD34 family. | For almost 30 years, the cell-surface protein CD34 has been widely used as a marker to assist in the identification and Summary isolation of hematopoietic stem cells (HSCs) and progenitors in preparation for bone-marrow transplantation. In addition, it has increasingly been used as a marker to help identify other tissu... | 18,987,355 |
Fast repair activities towards dGMP hydroxyl radical adducts by silybin and its analogues. | The repair activities of silybin (SLB) and its analogues towards the oxidizing deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts are investigated by pulse radiolytic techniques. On pulse irradiation of nitrous oxide saturated 2.0 mM dGMP aqueous solution containing 0.1 mM silybin at neutral pH, the transient... | 18,987,437 |
DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus. | To identify the repair dynamics involved in high linear energy transfer (LET) radiation-induced DNA damage, phospho-H2AX (gammaH2AX) foci formation was analyzed after cellular exposure to iron ions (Fe-ions, 500 MeV u(-1), 200 KeV microm(-1)). The foci located at DNA damage sites were visualized using immunocytochemica... | 18,987,440 |
Hepatitis B virus genotype-associated variability in antiviral response to adefovir dipivoxil therapy in Chinese Han population. | It is well known that different genotypes of hepatitis B virus (HBV) have a different sensitivity to interferon-alpha or lamivudine (nucleoside analogue) antiviral therapy. However, for adefovir dipivoxil (ADV, a nucleotide analogue), the antiviral response of the different genotypes remains to be clarified. In order t... | 18,987,454 |
Improvement in medication compliance and glycemic control with voglibose oral disintegrating tablet. | Good compliance with hypoglycemic therapy is important for diabetes treatment, since positive relationship between medication compliance and glycemic control has been reported. To improve medication compliance, the oral disintegrating tablet technology that facilitates drug administration without water has been employe... | 18,987,459 |
Anti-inflammatory action of a phosphatidylcholine, phosphatidylethanolamine and N-acylphosphatidylethanolamine-enriched diet in carrageenan-induced pleurisy. | Phosphatidylcholine (PC)-derived choline exhibits anti-inflammatory properties in stress conditions. Phosphatidylethanolamine (PE) and N-acylphosphatidylethanolamines (NAPEs) are endogenous bioactive phospholipids linked to the PC and endocannabinoid metabolisms. We hypothesized that an increased dietary input of PC, P... | 18,987,473 |
Design and fabrication of three-dimensional scaffolds for tissue engineering of human heart valves. | We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph. The data derived from the X-ray computed tomogram were processed by a computer-aided design program to reconstruct a human heart... | 18,987,474 |
Prenatal diagnosis of thanatophoric dysplasia by 3-D helical computed tomography and genetic analysis. | We report the first case of thanatophoric dysplasia (TD) successfully diagnosed in utero by a combination of 2-D ultrasound, computed tomography (CT) 3-D imaging and genetic analysis at 26 weeks' gestation. Prenatal sonographic examinations performed at 23 weeks' gestation revealed micromelic shortening of the limbs, r... | 18,987,480 |
The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2, et al. | Kallmann syndrome (KS) combines hypogonadotropic hypogonadism and anosmia. Anosmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to gonadotropin-releasing hormone (GnRH) deficiency, which presumably results from a failure of the embryonic migration of neuroendocrine GnRH... | 18,987,492 |
Genetics of spermatogenic failure. | Spermatogenesis is an ongoing developmental process in adult testes that requires the coordinated expression of many genes. The genetic causes of spermatogenic failure in men remain largely unknown, though abnormalities in the sex chromosomes constitute a significant portion of them. In this review, we focus on 3 disor... | 18,987,499 |
The value of a breast care nurse in supporting rural and remote cancer patients in Queensland. | The role of the breast care nurse (BCN) in the Queensland's Supporting Rural Women With Breast Cancer Project was evaluated by mixed methodology. Through questionnaire and interview, patients provided views about the nurse's role under the categories of awareness, access, coordination, information, and psychosocial, em... | 18,987,503 |
Young female breast cancer survivors: their sexual function and interest in sexual enhancement products and services. | Although American women are living longer after a breast cancer diagnosis, they may experience significant alterations in sexual function. However, little is known about the types of strategies that women are interested in using to address these sexual issues. This study used a reliable and valid instrument, the Sexual... | 18,987,508 |
Managing distress in oncology patients: description of an innovative online educational program for nurses. | The American Psychosocial Oncology Society and the Individual Cancer Assistance Network have launched the online continuing education accredited program "ICAN: Distress Management for Oncology Nursing" to address the ability of oncology nurses to assess, treat, and refer patients with a range of psychosocial problems. ... | 18,987,517 |
Polymorphisms in interleukin 1 beta and interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer. | Identifying molecular markers for tumor recurrence is critical in successfully selecting patients with stage II colon cancer who are more likely to benefit from adjuvant chemotherapy. Interleukin 1 beta (IL1B) and interleukin 1 receptor antagonist (IL1RN) have been shown to play a critical role in the early onset of tu... | 18,987,561 |
A comparison of functional assessment instruments and work status in chronic back pain. | The aim of this cross sectional study was to analyse whether low back pain (LBP) functional assessment instruments correlate well with work status measures. This study was a cross sectional study that enrolled 375 patients with chronic LBP attending back pain outpatient clinics of a University Hospital and a specialist... | 18,987,564 |
Cardiac protection by volatile anesthetics. A review. | All volatile anesthetics have cardiac depressant effects that decrease myocardial oxygen demand and may thus improve the myocardial oxygen balance during ischemia. Recent experimental evidence has clearly demonstrated that, in addition to these indirect effects, volatile anesthetic agents also directly protect from isc... | 18,987,572 |
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder. | The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and cholinesterase reactivators (oximes). Oximes can react - except their reactivating effect on cholinesterases - directly with cholinoreceptors. HI-6 is an oxime that may have an inhibitory effect on the... | 18,987,577 |
Structure-efficiency relationship in derivatives of stilbene. Comparison of resveratrol, pinosylvin and pterostilbene. | Oxidative stress is related to a number of autoimmune diseases, e.g. rheumatoid arthritis, cancer, etc. The main source of pathologically working reactive oxygen species (ROS) are activated polymorphonuclear leukocytes (PMNL). There are some papers comparing structure - pharmacological efficiency relationship of vegeta... | 18,987,580 |
Perfluorinated compounds: occurrence and risk profile. | Perfluorinated compounds (PFCs) such as perfluoro-octane sulphonate (PFOS) and perfluorooctanoic acid (PFOA) are emerging environmental pollutants, arising mainly from their use as surface treatment chemicals, polymerization aids and surfactants. They are ubiquitous, persistent and bioaccumulative in the environment. P... | 18,987,583 |
Mercury in human hair as an indicator of the fish consumption. | Mercury and most of its compounds are extremely toxic and should be handled with care. It can be inhaled and absorbed through the skin and mucous membranes. The most toxic forms of mercury are its organic compounds such as dimethylmercury and methylmercury. Fish have a natural tendency to accumulate mercury. Methylmerc... | 18,987,591 |
Hyaluronan influence on the onset of chondrogenic differentiation of mesenchymal stem cells. | Hyaluronan (HA) is an abundant component of chondrogenic tissue hence it is often used as a fundamental constituent in cartilage tissue substitutes. However, effects of different molecular weight HA on chondrogenic differentiation are not clear. The aim was to evaluate modulation of mesenchymal stem cell (MSC) early ch... | 18,987,597 |
WNT11 acts as a directional cue to organize the elongation of early muscle fibres. | The early vertebrate skeletal muscle is a well-organized tissue in which the primitive muscle fibres, the myocytes, are all parallel and aligned along the antero-posterior axis of the embryo. How myofibres acquire their orientation during development is unknown. Here we show that during early chick myogenesis WNT11 has... | 18,987,628 |
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. | The X-ray structure of a pentameric ligand-gated ion channel from Erwinia chrysanthemi (ELIC) has recently provided structural insight into this family of ion channels at high resolution. The structure shows a homo-pentameric protein with a barrel-stave architecture that defines an ion-conduction pore located on the fi... | 18,987,630 |
The impact of O2 availability on human cancer. | During the past century it has been established that regions within solid tumours experience mild to severe O(2) deprivation owing to aberrant vascular function. These hypoxic regions are associated with altered cellular metabolism, as well as increased resistance to radiation and chemotherapy. As discussed in this Tim... | 18,987,634 |
Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. | The main genetic predisposition to type 1 diabetes (T1D) is known to be conferred by the HLA-DRB1, -DQA1 and -DQB1 genes in the major histocompatibility complex (MHC). Other genetic factors within this complex are known to contribute, but their identity has often been controversial. This picture is shared with several ... | 18,987,644 |
The expanding genetic overlap between multiple sclerosis and type I diabetes. | Familial clustering of autoimmune disease is well recognized and raises the possibility that some susceptibility genes may predispose to autoimmunity in general. In light of this observation, it might be expected that some of the variants of established relevance in one autoimmune disease may also be relevant in other ... | 18,987,646 |
Unusual echocardiographic features seen in a case of giant cell myocarditis. | The case of an 18-year-old college football player with a recent history of streptococcal pharyngitis who was experiencing progressive disabling dyspnea on exertion with easy fatigability and lack of stamina, and was taken to the hospital after a syncopal episode is described. The patient was initially diagnosed with h... | 18,987,760 |
Antiphospholipid antibodies and atherosclerosis: insights from systemic lupus erythematosus and primary antiphospholipid syndrome. | The issue of atherosclerosis in the antiphospholipid syndrome (APS) is receiving considerable attention within and without the autoimmune setting. Measurement of arterial intima media thickness (IMT) of is an easy and surrogate means of detecting subclinical atherosclerosis. This technique has been applied to patients ... | 18,987,784 |
The HELP assay. | Genomic representations using ligation-mediated PCR have been used successfully as the foundation for a number of high-throughput assays. HpaII tiny fragment enrichment by ligation-mediated PCR (HELP) is an example of the use of such representations to study cytosine methylation in the genome. The HELP assay differs fr... | 18,987,808 |
Restriction landmark genomic scanning: analysis of CpG islands in genomes by 2D gel electrophoresis. | Restriction landmark genomic scanning (RLGS) is a method that provides a quantitative genetic and epigenetic (cytosine methylation) assessment of thousands of CpG islands in a single gel without prior knowledge of gene sequence. The method is based on two-dimensional separation of radiolabeled genomic DNA into nearly 2... | 18,987,812 |
Profiling DNA methylation from small amounts of genomic DNA starting material: efficient sodium bisulfite conversion and subsequent whole-genome amplification. | noindent Sodium bisulfite modification-based fine mapping of methylated cytosines represents the gold standard technique for DNA methylation studies. A major problem with this approach, however, is that it results in considerable DNA degradation, and large quantities of genomic DNA material are needed if numerous genom... | 18,987,828 |
Visualizing dendritic cell migration within the skin. | Dendritic cells (DCs) within the skin are a heterogeneous population of cells, including Langerhans cells of the epidermis and at least three subsets of dermal DCs. Collectively, these DCs play important roles in the initiation of adaptive immune responses following antigen challenge of the skin as well as being mediat... | 18,987,873 |
Hamartomas of the oro- and nasopharyngeal cavity in infancy: two cases and a short review. | Oro- and nasopharyngeal masses are rare in infancy and consist of developmental anomalies and, mostly benign, neoplasms. We report two infants with a tumour in the ear-nose-throat region. As shown by our cases, the clinical presentation of an oropharyngeal mass in infancy varies from respiratory insufficiency at birth ... | 18,987,884 |
Functional genes and proteins of Trichinella spp. | Research of Trichinella proteins has been conducted with emphasis on excretory-secretory (E-S) products of muscle larvae because of two reasons. The first is that it has prominent and narrow specific antigenicity, and the second is that it may play some role in nurse cell formation after being secreted into host muscle... | 18,987,885 |
A proposed staging system for intrahepatic cholangiocarcinoma. | The American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) staging system for liver cancer is based on data exclusively derived from hepatocellular carcinoma (HCC) patients and thus may be inappropriate for patients with intrahepatic cholangiocarcinoma (ICC). We sought to empirically derive... | 18,987,916 |
Total laparoscopic resection of the gallbladder together with the gallbladder bed. | Patients with carcinoma of the gallbladder that is preoperatively diagnosed by radiology do not undergo laparoscopic resection, because such surgery is thought to worsen the prognosis of gallbladder carcinoma. However, the prognosis for patients with incidental T2 gallbladder carcinoma who are treated laparoscopically ... | 18,987,927 |
Assessment of liver function for successful hepatectomy in patients with hepatocellular carcinoma with impaired hepatic function. | This study aimed to construct a formula for assessing liver function in order to prevent post-hepatectomy liver failure. A formula was constructed by analyzing data from 28 patients with hepatocellular carcinoma (HCC) with liver cirrhosis operated on between 1981 and 1984. Next, we evaluated the validity of this formul... | 18,987,929 |
A patient with gallbladder cancer with paraaortic lymph node and hepatic metastases who has survived for more than 13 years after the primary extended radical operation. | Gallbladder cancer is a disease with poor prognosis, especially when it is associated with distant metastasis. Here we report a rare case of a patient with gallbladder cancer with extensive local and distant lymph node metastases and multiple liver metastases who has survived for more than 13 years through aggressive t... | 18,987,937 |
Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids. | The anti-proliferative activity of hesperetin, hesperidin, neohesperidin and rutin was evaluated on human hepatoma cell lines (Hep G2) and correlated to their antioxidant activity. The results obtained showed strong anti-proliferative effects of hesperidin and neohesperidin, considerably higher than the other two addit... | 18,987,944 |
Improving nerve regeneration of acellular nerve allografts seeded with SCs bridging the sciatic nerve defects of rat. | The objective of the paper is to evaluate the effect of acellular nerve allografts (ANA) seeded with Schwann cells to promote nerve regeneration after bridging the sciatic nerve defects of rats and to discuss its acting mechanisms. Schwann cells were isolated from neonatal Wistar rats. In vitro Schwann cells were micro... | 18,987,968 |
The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review. | The recent discovery of two defects (ribose-5-phosphate isomerase deficiency and transaldolase deficiency) in the reversible part of the pentose phosphate pathway (PPP) has stimulated interest in this pathway. In this review we describe the functions of the PPP, its relation to other pathways of carbohydrate metabolism... | 18,987,987 |
[Lipid profiles and therapy status in the secondary prevention of high risk patients with cardiovascular disease and/or diabetes mellitus: the Austrian Hospital Screening Project (HSP)]. | Cardiovascular disease is the major cause of morbidity and premature death in most European populations. Due to its prominent role as a risk factor for cardiovascular mortality, lowering of low density lipoprotein cholesterol (LDL-C) levels is the main goal for management of dyslipidemia. To evaluate lipid profiles and... | 18,988,009 |
Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning. | Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best therapy. Despite the recognition of adverse effects, gastric lavage is commonly done in Asia. We aimed to identify studies assessing... | 18,988,062 |
Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II. | Allergic contact dermatitis remains an important problem worldwide. The objective of this study was to analyze patch test positivity trends of the North American Contact Dermatitis Group. Publications from 1970 to 2002 were reviewed and re-analyzed. Statistical significance was determined with a Cochran-Armitage trend ... | 18,988,088 |
UV inactivation of adenovirus type 4 measured by integrated cell culture qPCR. | Recent changes to water quality regulations may increase the prevalence of ultraviolet (UV) disinfection in water treatment applications. Adenoviruses currently pose a tremendous challenge to UV disinfection due to the high dose requirements for inactivation. This study validates a strategy combining cell culture and q... | 18,988,100 |
Total and methyl mercury in wetland soils and sediments of Louisiana's Pontchartrain Basin (USA). | Accumulation of methylmercury (MeHg) in aquatic biota is a primary toxicological concern associated with Hg contamination in the environment. This study reports total mercury (THg) and MeHg measurements in 11 swamp and 24 marsh soils/sediments in wetlands surrounding Lake Pontchartrain and Lake Maurepas located in Loui... | 18,988,103 |
Assessment of Pb, Cd, Cr and Ag leaching from electronics waste using four extraction methods. | Heavy metals present in electronic components may leach upon disposal and therefore pose significant environmental hazards. The potential leaching of Pb, Cd, Cr and Ag from PC cathode ray tubes, printed circuit boards (PCBs), PC mice, TV remote controls, and mobile phones was assessed. After controlled crushing, each c... | 18,988,110 |
Conducting pharmaceutical R&D in India - Critical components of entry strategies. | In the face of challenges associated with expiring patents, the rising cost of R&D and pressure on pricing, most major pharmaceutical companies are seeking ways to enhance productivity, reduce costs and augment the late-stage new-product pipeline. Exploiting the R&D capabilities in India is one option that can ... | 18,988,126 |
Management of postkeratoplasty ametropia: IntraLASIK after penetrating keratoplasty. | The authors describe a technique of laser in situ keratomileusis (LASIK) for the management of postkeratoplasty ametropia using a femtosecond laser for flap creation. The first step was the placement of a disposable suction fixation ring to ensure that it was well-centered on the graft. The applanation cone was applied... | 18,988,156 |
Nonvisible subthreshold micropulse diode laser (810 nm) treatment of central serous chorioretinopathy. A pilot study. | To verify the efficacy of nonvisible micropulse diode laser irradiation in the treatment of central serous chorioretinopathy (CSC). Twenty-two patients with CSC for a total of 24 eyes with a disease duration longer than 3 months were included in a prospective study. Patients underwent Early Treatment Diabetic Retinopat... | 18,988,165 |
Inferior sclerotomies without subretinal fluid drainage for exudative retinal detachment in diffuse retinal pigment epitheliopathy. | To evaluate the efficacy of inferior sutureless sclerotomies without subretinal fluid drainage for the treatment of bullous exudative retinal detachment secondary to diffuse retinal pigment epitheliopathy. A retrospective interventional case series of eyes treated with two inferior postequatorial full-thickness sclerot... | 18,988,170 |
Triamcinolone-assisted vitreous imaging using B-scan ultrasonography. | To evaluate the echographic vitreoretinal patterns before and after intravitreal injection of triamcinolone (IVTA) in eyes with opaque media and several pathologies. One eye with pseudophakic cystoid macular edema and two eyes with postoperative endophthalmitis and opaque media were examined using B-scan ultrasonograph... | 18,988,184 |
Kinetic modeling of a bi-enzymatic system for efficient conversion of lactose to lactobionic acid. | A model has been developed to describe the interaction between two enzymes and an intermediary redox mediator. In this bi-enzymatic process, the enzyme cellobiose dehydrogenase oxidizes lactose at the C-1 position of the reducing sugar moiety to lactobionolactone, which spontaneously hydrolyzes to lactobionic acid. 2,2... | 18,988,269 |
Investigations of an O-H...S hydrogen bond via Car-Parrinello and path integral molecular dynamics. | The presence of intramolecular hydrogen bonds influences the binding energy, tautomeric equilibrium, and spectroscopic properties of various classes of organic molecules. This article discusses the O-H...S bridge, one of the less commonly investigated types of intramolecular interactions. 3-mercapto-1,3-diphenylprop-2-... | 18,988,272 |
Thin core needle biopsy crush preparations in conjunction with fine-needle aspiration for the evaluation of thyroid nodules: a complementary approach. | Fine-needle aspiration (FNA) is widely accepted as the initial test to evaluate thyroid nodules; however, inadequate and suboptimal specimens have been 1 of its limitations. Unsatisfactory rates of 4.1% to 43% have been reported, but suboptimal specimens with adequate epithelial cells and other limiting factors, such a... | 18,988,285 |
Investigation of stressful life events in patients with systemic sclerosis. | To assess the occurrence of stressful life events in the year before the initiation of systemic sclerosis. A consecutive series of 40 patients with systemic sclerosis (mean age (56.3+/-11.9) years, mean disease duration (4.3+/-3.1) years; 32 females and 8 males), including 28 with diffuse cutaneous scleroderma and 12 w... | 18,988,303 |
Free soluble receptor activator of nuclear factor-kappab ligand in gingival crevicular fluid correlates with distinct pathogens in periodontitis patients. | The aim of the experiment was to investigate the levels of free soluble receptor activator of nuclear factor-kb ligand (sRANKL) in periodontal health and disease and their correlations to clinical parameters and important periodontal pathogens. Chronic periodontitis (n=35) and periodontally healthy (n=38) subjects part... | 18,988,315 |
[Weight history of patients with newly diagnosed type 2 diabetes--secondary publication]. | The aim was to estimate and illustrate the weight history of 1,320 newly diagnosed diabetic patients according to patient characteristics at diagnosis. The median recalled weight gain from age 20 to diabetes diagnosis at a median age of 65.3 years was 14.7 kg. The average weight gain from 10 years prior to diabetes dia... | 18,988,367 |
Stroke in Pakistan. | Stroke is the most common cause of disability and a leading cause of mortality world wide. Though the incidence is falling in West but probably is rising in Asia. The burden of stroke risk factors in Pakistan is enormous e.g. by 2020 Pakistan will be 4th most populous country in terms of diabetic patients. Similarly ev... | 18,988,415 |
Salvage decompressive craniectomy in malignant MCA infarcts--results of local experience at Shifa International Hospital, Islamabad, Pakistan. | Malignant infarctions of the middle cerebral artery (MCA) have high mortality. Recent studies showed decreased mortality with good functional outcome in young people with decompressive surgery. We report prospective, non-randomized case series of live patients in whom successful life saving decompressive craniectomy wa... | 18,988,416 |
Variables that predict academic achievement in the Spanish compulsory secondary educational system: a longitudinal, multi-level analysis. | This article presents a study whose objective was to identify certain personal and institutional variables that are associated with academic achievement among Spanish, secondary school students, and to analyze their influence on the progress of those students over the course of that stage of their education. In order t... | 18,988,427 |
Traumatic events and tonic immobility. | Tonic immobility is a basic defense strategy which has not been studied in depth in humans. Data suggest that it may be a relatively frequent phenomenon in victims of rape and sexual abuse, but its occurrence has not been systematically explored in other types of trauma. We carried out a retrospective study in a sample... | 18,988,436 |
[Serum proteome profiling for ovarion cancer diagnosis using ClinProt magnetic bead technique and MALDI-TOF-mass-spectrometry]. | Using reverse-phase (MB-HIC 8 and HB-HIC 18) weak cation exchange (MB-WCX) and metal affinity ClinProt magnetoc beads peptides and protein factions were obtained from human sera for their profiling by MALDI-TOF mass spectrometry. Proteome profiling of sera from I-IV stage ovarian cancer patients (47 women, average age ... | 18,988,457 |
[Lentiviral vectors]. | The delivery of genetic material to mammalian cells has a great importance for modern fundamental biology, biomedicine, biotechnology, agriculture and veterinary medicine. The development of new efficient techniques of gene transfer to human cells has led to the establishment of gene therapy, a novel type of treatment ... | 18,988,539 |
The evolving process of European combination product review, Part I. | A new European guideline on drug-eluting stents (DES) introduces for the first time detailed information that European drug authorities should review concerning the medicinal substance that is incorporated into this type of drug-device combination product. Part I of this article discusses European requirements that app... | 18,988,546 |
Improving biosensors at the nanoscale. | This, the second in the series on the impact of nanotechnology on different types of medical devices, looks again at the field of medical and biological diagnosis and detection. It examines how knowledge at the nanoscale is also helping to develop new generations of miniature devices that are capable of detecting, in v... | 18,988,548 |
When nurses do the unthinkable. | This series explores the reasons why some nurses abuse or even kill the patients in their care and asks why such unthinkable behaviour is so difficult to understand. | 18,988,562 |
An overview of topical negative pressure therapy in wound care. | This article examines the historical development of topical negative pressure (TNP) therapy, the growing range of devices available and future possibilities for this treatment. The use of vacuum-assisted closure (VAC), different negative pressure settings and alternative TNP devices are discussed. Further guidance and ... | 18,988,585 |
Cold-induced modulation and functional analyses of the DRE-binding transcription factor gene, GmDREB3, in soybean (Glycine max L.). | DREB (dehydration-responsive element-binding protein) transcription factors have important roles in the stress-related regulation network in plants. A DREB orthologue, GmDREB3, belonging to the A-5 subgroup of the DREB subfamily, was isolated from soybean using the RACE (rapid amplification of cDNA ends) method. Northe... | 18,988,621 |
Relation of mechanical dyssynchrony with underlying cardiac structure and performance in chronic systolic heart failure: implications on clinical response to cardiac resynchronization. | The aim of this study is to describe the relationship between ventricular mechanical dyssynchrony (VMD) and echocardiographic indices of cardiac remodelling. We evaluated 219 ambulatory patients with chronic systolic heart failure [left ventricular ejection fraction (LVEF) <or= 35%, New York Heart Association functi... | 18,988,651 |
Comparison between colour-coded and spectral tissue Doppler measurements of systolic and diastolic myocardial velocities: effect of temporal filtering and offline gain setting. | Colour tissue Doppler (TD) has been reported to underestimate the longitudinal myocardial motion velocities measured with spectral TD. This study evaluates the effect of temporal smoothing and offline gain settings on the results of velocity measurements with these two methods and the difference between them. In 57 pat... | 18,988,658 |
Effects of early progressive eccentric exercise on muscle size and function after anterior cruciate ligament reconstruction: a 1-year follow-up study of a randomized clinical trial. | The authors previously reported that focused eccentric resistance training during the first 15 weeks following anterior cruciate ligament reconstruction (ACL-R) induced greater short-term increases in muscle volume, strength, and measures of function relative to standard rehabilitation. The purpose of this study was to... | 18,988,664 |
Lower-extremity strength differences predict activity limitations in people with chronic stroke. | Body system impairments following stroke have a complex relationship with functional activities. Although gait and balance deficits are well-documented in people after stroke, the overlapping influence of body impairments makes it difficult to prioritize interventions. This study examined the relationship between prosp... | 18,988,665 |
Expression of immunoregulatory molecules by thyrocytes protects nonobese diabetic-H2h4 mice from developing autoimmune thyroiditis. | One approach to prevent tissue destruction by autoimmune attack in organ-specific autoimmune diseases is to protect the target tissue from autoimmune reaction, regardless of its persistent activity. To provide proof-of-principle for the feasibility of this approach, the immunoregulatory molecules, TNF-related apoptosis... | 18,988,676 |
An ancient horizontal gene transfer between mosquito and the endosymbiotic bacterium Wolbachia pipientis. | The extent and biological relevance of horizontal gene transfer (HGT) in eukaryotic evolution remain highly controversial. Recent studies have demonstrated frequent and large-scale HGT from endosymbiotic bacteria to their hosts, but the great majority of these transferred genes rapidly become nonfunctional in the recip... | 18,988,686 |
Exposure of alpha2,6-sialylated lactosaminic chains marks apoptotic and necrotic death in different cell types. | Many observations have reported glycosylation changes associated with apoptosis in different biological systems, although none of these has shown any general significance. In this work, we show that in cell lines from different histological origin, (colon, breast, pancreas, and bladder cancer) as well as in normal huma... | 18,988,689 |
Gut peristalsis is governed by a multitude of cooperating mechanisms. | Peristaltic motor activity of the gut is an essential activity to sustain life. In each gut organ, a multitude of overlapping mechanisms has developed to acquire the ability of coordinated contractile activity under a variety of circumstances and in response to a variety of stimuli. The presence of several simultaneous... | 18,988,693 |
Effects of treatment of renal osteodystrophy on bone histology. | Renal osteodystrophy is characterized by abnormalities in bone turnover, mineralization, and bone volume. The effects of treatment modalities for renal osteodystrophy on bone should be analyzed with respect to these abnormalities. The major treatment modalities for renal osteodystrophy include phosphate binders, vitami... | 18,988,701 |
Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. | Despite the fact that many nuclear receptors are ligand dependent, the existence of obligate regulatory ligands is debated for some receptors, including steroidogenic factor 1 (SF-1). Although fortuitously bound bacterial phospholipids were discovered in the structures of the SF-1 ligand-binding domain (LBD), these lip... | 18,988,706 |
Blood pressure control and pharmacotherapy patterns in the United States before and after the release of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines. | Despite recommendations from the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7), only 36.8% of patients were at target blood pressure (BP) in 2003 and 2004. The objective of this study was to assess improvements in BP control and treatment patterns before... | 18,988,718 |
Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells. | The CD8 co-receptor can modulate CD8(+) T cell function through its contributions to T cell receptor (TCR) binding and signaling. Here we show that IFN-gamma and IL-4 exert opposing effects on the expression of CD8alpha mRNA and surface CD8 protein during CD8(+) T cell activation. IL-4 caused down-regulation of surface... | 18,988,742 |
Analytical distributions for stochastic gene expression. | Gene expression is significantly stochastic making modeling of genetic networks challenging. We present an approximation that allows the calculation of not only the mean and variance, but also the distribution of protein numbers. We assume that proteins decay substantially more slowly than their mRNA and confirm that m... | 18,988,743 |
MALDI-TOF MS genotyping of polymorphisms related to 1-carbon metabolism using common and mass-modified terminators. | Large cohort studies may provide sufficient power to disentangle the role of polymorphisms related to 1-carbon metabolism and chronic diseases, but they require fast, accurate, high-throughput genotyping techniques. MALDI-TOF mass spectrometry has been adapted to rapid fine mapping using various approaches for allele d... | 18,988,749 |
Fluid shear stress induces arterial differentiation of endothelial progenitor cells. | Endothelial progenitor cells (EPCs) are mobilized from bone marrow to peripheral blood and contribute to angiogenesis in tissues. In the process, EPCs are exposed to the shear stress generated by blood flow and tissue fluid flow. Our previous study showed that shear stress promotes differentiation of EPCs into mature e... | 18,988,767 |
Discordance in spirometric interpretations using three commonly used reference equations vs national health and nutrition examination study III. | Spirometry plays an essential role in the diagnosis and management of pulmonary diseases. The accurate interpretation of spirometric data depends on comparison to a reference population to identify abnormalities in ventilatory function. National guidelines recommended the use of the National Health and Nutrition Examin... | 18,988,777 |
Tumors stimulate platelet delivery of angiogenic factors in vivo: an unexpected benefit. | The interaction between platelets and the tumor microenvironment results in the modulation of angiogenesis, although the mechanisms governing this regulation remain unclear. This study explores the differences in the communication between wounded tissues and healthy, tumor-conditioned, and frozen platelets. Platelet-ri... | 18,988,799 |
Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis. | Many tumor types express matrix metalloproteinase-1 (MMP-1); its collagenase activity facilitates both tumor cell invasion and metastasis. MMP-1 expression is also associated with increased angiogenesis; however, the exact mechanism by which this occurs is not clear. MMP-1 proteolytically activates protease activated r... | 18,988,801 |
Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis. | Cryptochromes (CRY) are photolyase-like blue-light receptors that mediate light responses in plants and animals. How plant cryptochromes act in response to blue light is not well understood. We report here the identification and characterization of the Arabidopsis CIB1 (cryptochrome-interacting basic-helix-loop-helix) ... | 18,988,809 |
Consciousness and anesthesia. | When we are anesthetized, we expect consciousness to vanish. But does it always? Although anesthesia undoubtedly induces unresponsiveness and amnesia, the extent to which it causes unconsciousness is harder to establish. For instance, certain anesthetics act on areas of the brain's cortex near the midline and abolish b... | 18,988,836 |
Biology, politics, and the emerging science of human nature. | In the past 50 years, biologists have learned a tremendous amount about human brain function and its genetic basis. At the same time, political scientists have been intensively studying the effect of the social and institutional environment on mass political attitudes and behaviors. However, these separate fields of in... | 18,988,845 |
Global protein stability profiling in mammalian cells. | The abundance of cellular proteins is determined largely by the rate of transcription and translation coupled with the stability of individual proteins. Although we know a great deal about global transcript abundance, little is known about global protein stability. We present a highly parallel multiplexing strategy to ... | 18,988,847 |
Fat metabolism links germline stem cells and longevity in C. elegans. | Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans, which in turn regulates longevity. GSC arrest promotes systemic lipo... | 18,988,854 |
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