title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Gene expression and isoform variation analysis using Affymetrix Exon Arrays. | Alternative splicing and isoform level expression profiling is an emerging field of interest within genomics. Splicing sensitive microarrays, with probes targeted to individual exons or exon-junctions, are becoming increasingly popular as a tool capable of both expression profiling and finer scale isoform detection. De... | 18,990,248 |
Review on solving the inverse problem in EEG source analysis. | In this primer, we give a review of the inverse problem for EEG source localization. This is intended for the researchers new in the field to get insight in the state-of-the-art techniques used to find approximate solutions of the brain sources giving rise to a scalp potential recording. Furthermore, a review of the pe... | 18,990,257 |
Patients' attitude towards the use of a chaperone in breast examination. | The aim of this study was to assess the attitude and the preferences of patients towards the use of a chaperone during breast examination. A two-part questionnaire was circulated among 204 consecutive new patients, attending both symptomatic breast and screened assessment clinics. A total of 200 questionnaires were ful... | 18,990,268 |
Urgent cholecystectomy for acute cholecystitis in a district general hospital - is it feasible? | Laparoscopic cholecystectomy has become the gold standard for treatment of symptomatic gall stone disease. However, its place remains controversial in the management of acute cholecystitis due to a high reported incidence of bile leaks and conversion rate. Tertiary referral centres have reported good results. We presen... | 18,990,272 |
Total hip arthroplasty in Klippel-Trenaunay syndrome. | Klippel-Trenaunay syndrome patients often suffer degenerative joint disease at an early age. Performing arthroplasty in these patients is particularly difficult for a number of reasons. In this case report, we describe the second reported case of total hip replacement in Klippel-Trenaunay syndrome, using novel techniqu... | 18,990,275 |
Spinal muscular atrophy: advances in research and consensus on care of patients. | Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by degeneration of spinal cord motor neurons and muscular atrophy. Advances in recent research have led to understanding of the molecular genetics of SMA. Therapeutic strategies have been developed according to the unique genomic structure of... | 18,990,310 |
Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. | To determine whether dehydroepiandrosterone (DHEA) replacement therapy in hypoadrenal women improves performance, muscle protein accretion, and mitochondrial functions. Thirty-three hypoadrenal women were enrolled in the study from May 1, 2002, through May 31, 2003. Twenty-eight completed a 12-week, prospective, random... | 18,990,320 |
[Combination and transformation of toxin and blood stasis in etiopathogenesis of thrombotic cerebro-cardiovascular diseases]. | According to the basic theory of traditional Chinese medicine (TCM), the pathogenetic factors such as platelet activation, adhesion, congregation and thrombosis fall into the category of blood stasis, while the pathological changes such as tissue necrosis, oxidative stress injury and inflammation, etc, are far beyond t... | 18,990,334 |
Possible role of GABAA-benzodiazepine receptor in anticonvulsant effects of Pasipay in rats. | To investigate the anticonvulsant effects of Pasipay, a commercially available preparation of hydro-alcoholic extract of Passiflora incarnata in rats. The anticonvulsant effects of hydro-alcoholic extract of P. incarnata, Pasipay, were observed by intracerebroventricular injection of 0.125, 0.25, 0.55 and 1.5 microg Pa... | 18,990,344 |
Genetic variability in residual feed intake in rainbow trout clones and testing of indirect selection criteria (Open Access publication). | Little is known about the genetic basis of residual feed intake (RFI) variation in fish, since this trait is highly sensitive to environmental influences, and feed intake of individuals is difficult to measure accurately. The purpose of this work was (i) to assess the genetic variability of RFI estimated by an X-ray te... | 18,990,354 |
T lymphocyte activation and cytokine expression in periapical granulomas and radicular cysts. | Radicular cysts (RCs) are periapical lesions resulting in jaw bone destruction. The inflammatory dental periapical granuloma (PG) is considered to be the origin of RC formation; however the mechanism of RC development remains unclear. Cell suspension from the surgically extirpated tissue of 27 RCs and 25 PGs was obtain... | 18,990,362 |
Patterns in dental enamel hypoplasia by sex and age at death in two archaeological populations. | Levels of enamel hypoplasia in past populations are frequently used to study health. However, few studies have looked at patterning in the occurrence of different types of hypoplasia. In this pilot study, skeletal remains from an Iron Age tomb at Pella in Jordan were analysed for the presence of linear and pit enamel h... | 18,990,363 |
Mental imagery as an emotional amplifier: application to bipolar disorder. | Cognitions in the form of mental images have a more powerful impact on emotion than their verbal counterparts. This review synthesizes the cognitive science of imagery and emotion with transdiagnostic clinical research, yielding novel predictions for the basis of emotional volatility in bipolar disorder. Anxiety is ext... | 18,990,364 |
Pilot study evaluating a progesterone vaginal ring for luteal-phase replacement in donor oocyte recipients. | To evaluate the proportions of women demonstrating adequate endometrial transformation during a mock cycle and the 8-week clinical pregnancy rate in a donor oocyte cycle using a P vaginal ring or P vaginal gel. Prospective, controlled, randomized trial. Donor egg program at an academic center. Women who are candidates ... | 18,990,373 |
Laparoscopic management of ureteral endometriosis in case of moderate-severe hydroureteronephrosis. | To evaluate prospectively the efficacy of laparoscopic ureterolysis versus ureteroureterostomy in women with ureteral endometriosis. Prospective study. Department of Obstetrics and Gynecology, Ospedale Sacro Cuore of Negrar, Verona, Italy, a tertiary care endometriosis referral center. Endometriotic patients with moder... | 18,990,377 |
Cost analysis model of outpatient management of ovarian hyperstimulation syndrome with paracentesis: "tap early and often" versus hospitalization. | To compare the cost of two treatment regimens for moderate to severe ovarian hyperstimulation syndrome (OHSS): conservative inpatient versus outpatient management with paracentesis. A decision-tree mathematical model comparing conservative inpatient versus outpatient management of moderate to severe OHSS was created. T... | 18,990,389 |
Effect of phosphate complexation on Cd2+ sorption by manganese dioxide (beta-MnO2). | Sorption of metal ions on oxide/hydroxide surfaces mediates the fate and transport of these ions in many natural systems. These metallic ions often exist in bulk in the aqueous phase as complexes with inorganic and organic ligands. In the present study, we investigated the sorption properties of manganese dioxide in th... | 18,990,403 |
Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: the FINE study. | Cohort and case-control studies found that lower serum total cholesterol is associated with depression. It is, however, unclear whether low cholesterol or its lipoprotein fractions are causally related to depression. Using a Mendelian randomization design, the potential association between apolipoprotein E (APOE) genot... | 18,990,452 |
Antenatal depression and male gender preference in Asian women in the UK. | to identify the prevalence of antenatal depression among Asian women living in the UK in one antenatal clinic, and to investigate the possible association with a desire for a male child and other risk factors. cross-sectional questionnaire-based study. general antenatal clinic in a hospital in Birmingham. 300 Asian wom... | 18,990,472 |
Cardiopulmonary resuscitation: knowledge and opinions among the U.S. general public. State of the science-fiction. | Cardiopulmonary resuscitation is undertaken more than 250,000 times annually in the United States. This study was undertaken to determine knowledge and opinions of the general public regarding cardiopulmonary resuscitation. Validated multisite community-based cross-sectional survey. Knowledge and opinions about resusci... | 18,990,479 |
Occurrence of pharmaceutically active compounds during 1-year period in wastewaters from four wastewater treatment plants in Seville (Spain). | Several pharmaceutically active compounds have been monitored during 1-year period in influent and effluent wastewater from wastewater treatment plants (WWTPs) to evaluate their temporal evolution and removal from wastewater and to know which variables have influence in their removal rates. Pharmaceutical compounds mon... | 18,990,491 |
[Allergy to betalactams: myth and realities]. | Allergic reactions to penicillins have been reported since the 1950s, shortly after their introduction as therapeutic agents. An increasing number of reported anaphylactic reactions and other adverse effects proved this to be a serious public health problem. Fifty years later, betalactam-induced hypersensitivity is the... | 18,990,520 |
Microbial genome count in cerebrospinal fluid compared with clinical characteristics in pneumococcal and Haemophilus influenzae type b meningitis in children. | Cerebrospinal fluid genome counts were determined by quantitative real-time polymerase chain reaction from 121 children: 36 with Streptococcus pneumoniae and 85 with Haemophilus influenzae meningitis. To examine the interactions of genome count and to determine its prognostic importance, we projected the results agains... | 18,990,528 |
Negative events and their potential risk of precipitating pathological forms of dental anxiety. | The purpose of the present study was to assess which types of experiences are most closely associated with pathological forms of dental anxiety. Data came from a sample of dental patients (n=1462). Pathological dental anxiety was operationalized in two ways: (1) a score of > or =36 on the Short form of the Dental An... | 18,990,543 |
Production of the Auger emitter 119Sb for targeted radionuclide therapy using a small PET-cyclotron. | The use of Auger electrons in radionuclide therapy of cancer is a promising tool for specific tumor cell killing of micrometastases and small tumors. The radioisotope (119)Sb has recently been identified as a potent Auger-emitter for therapy. We here present a method for producing this isotope using a low-energy cyclot... | 18,990,581 |
Renal insufficiency and anticancer drugs in elderly cancer patients: a subgroup analysis of the IRMA study. | The Renal Insufficiency and Anticancer Medications (IRMA) study is a French national, observational study which demonstrated the high prevalence of abnormal renal function in a population of 4684 solid tumor patients. Among them, 50-60% had decreased renal function, and 80% were treated with anticancer drugs that eithe... | 18,990,585 |
Vascular training and endovascular practice in Europe. | To evaluate the influence of the status of vascular surgery (VS) training paradigms on the actual practice of endovascular therapy among the European countries. An email-based survey concerning vascular surgery training models and endovascular practices of different clinical specialties was distributed to a VS educator... | 18,990,591 |
Antiepileptic drugs to treat pain in rheumatic conditions. Recommendations based on evidence-based review of the literature and expert opinion. | Neuropathic pain is commonly encountered in rheumatology practice, often associated with nociceptive mechanisms. It is caused by nervous system lesions, and the usual treatments with analgesics and anti-inflammatory drugs are mostly ineffective. Antiepileptic drugs (AED) have proved effective in relieving neuropathic p... | 18,990,602 |
Automatic real-time ECG coding methodology guaranteeing signal interpretation quality. | This paper introduces a new methodology for compressing ECG signals in an automatic way guaranteeing signal interpretation quality. The approach is based on noise estimation in the ECG signal that is used as a compression threshold in the coding stage. The Set Partitioning in Hierarchical Trees algorithm is used to cod... | 18,990,621 |
Vestibulo-ocular responses evoked via bilateral electrical stimulation of the lateral semicircular canals. | We investigated the vestibulo-ocular responses (VORs) evoked by bilateral electrical stimulation of the nerves innervating horizontal semicircular canals in squirrel monkeys and compared these responses to those evoked by unilateral stimulation. In response to sinusoidal modulation of the electrical pulse rate, the VOR... | 18,990,631 |
Space-time adaptive decision feedback neural receivers with data selection for high-data-rate users in DS-CDMA systems. | A space-time adaptive decision feedback (DF) receiver using recurrent neural networks (RNNs) is proposed for joint equalization and interference suppression in direct-sequence code-division multiple-access (DS-CDMA) systems equipped with antenna arrays. The proposed receiver structure employs dynamically driven RNNs in... | 18,990,643 |
Robust stability analysis for interval cohen-grossberg neural networks with unknown time-varying delays. | In this paper, robust stability problems for interval Cohen-Grossberg neural networks with unknown time-varying delays are investigated. Using linear matrix inequality, M -matrix theory, and Halanay inequality techniques, new sufficient conditions independent of time-varying delays are derived to guarantee the uniquene... | 18,990,645 |
Brain activity-based image classification from rapid serial visual presentation. | We report the design and performance of a brain-computer interface (BCI) system for real-time single-trial binary classification of viewed images based on participant-specific dynamic brain response signatures in high-density (128-channel) electroencephalographic (EEG) data acquired during a rapid serial visual present... | 18,990,647 |
An experimental study of the decay of turbulent puffs in pipe flow. | As reported in a number of recent studies, turbulence in pipe flow is transient for Re<2000 and the flow eventually always returns to the laminar state. Generally, the lifetime of turbulence has been observed to increase rapidly with Reynolds number but there is currently no accord on the exact scaling behaviour. In... | 18,990,664 |
Critical threshold in pipe flow transition. | This study provides a numerical characterization of the basin of attraction of the laminar Hagen-Poiseuille flow by measuring the minimal amplitude of a perturbation required to trigger transition. For pressure-driven pipe flow, the analysis presented here covers autonomous and impulsive scenarios where either the flow... | 18,990,665 |
Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease. | Levosimendan is clinically used to improve myocardial contractility by enhancing calcium sensitivity of force generation. The effects of levosimendan on skeletal muscle contractility are unknown. Patients with chronic obstructive pulmonary disease (COPD) suffer from diaphragm weakness, which is associated with decrease... | 18,990,676 |
Severe exacerbations and decline in lung function in asthma. | To evaluate the association between asthma exacerbations and the decline in lung function, as well as the potential effects of an inhaled corticosteroid, budesonide, on exacerbation-related decline in patients with asthma. To determine whether severe asthma exacerbations are associated with a persistent decline in lung... | 18,990,678 |
Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP). | Rhesus rhadinovirus (RRV) is currently the closest known, fully sequenced homolog of human Kaposi sarcoma-associated herpesvirus. Both these viruses encode complement inhibitors as follows: Kaposi sarcoma-associated herpesvirus-complement control protein (KCP) and RRV-complement control protein (RCP). Previously we cha... | 18,990,693 |
Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. | The transient receptor potential canonical (TRPC) family channels are proposed to be essential for store-operated Ca2+ entry in endothelial cells. Ca2+ signaling is involved in NF-kappaB activation, but the role of store-operated Ca2+ entry is unclear. Here we show that thrombin-induced Ca2+ entry and the resultant AMP... | 18,990,707 |
Puffing style and human exposure minimally altered by switching to a carbon-filtered cigarette. | Potential Reduced Exposure tobacco Products (PREP) are intended to lower human exposure to toxic constituents of tobacco smoke, but rigorous clinical evaluations are required to assess such claims. The present study assessed human smoking behavior and short-term exposure to a new carbon-filtered PREP, Marlboro UltraSmo... | 18,990,741 |
Self-report versus medical records for assessing cancer-preventive services delivery. | Accurate measurement of cancer-preventive behaviors is important for quality improvement, research studies, and public health surveillance. Findings differ, however, depending on whether patient self-report or medical records are used as the data source. We evaluated concordance between patient self-report and medical ... | 18,990,740 |
N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNA. | Head and neck cancers are causally related to alcohol consumption, but the underlying mechanisms are unclear. Ethanol is metabolized to acetaldehyde, an experimental carcinogen. Quantitation of the major DNA adduct of acetaldehyde, N2-ethylidenedeoxyguanosine, in human tissues could help to elucidate the mechanism of a... | 18,990,745 |
Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. | Colorectal cancer literature regarding the interaction between polymorphisms in carcinogen-metabolizing enzymes and red meat intake/doneness is inconsistent. A case-control study was conducted to evaluate the interaction between red meat consumption, doneness, and polymorphisms in carcinogen-metabolizing enzymes. Color... | 18,990,750 |
Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. | Proliferative verrucous leukoplakia (PVL) represents a rare but highly aggressive form of oral leukoplakia with > 70% progressing to malignancy. Yet, PVL remains biologically and genetically poorly understood. This study evaluated the cell cycle regulatory genes, p16INK4a and p14ARF, for homozygous deletion, loss of... | 18,990,760 |
What's new with the FHA's Section 242? | FHA hospital mortgage insurance, also called the Section 242 program, acts as a credit enhancement that allows borrowers to issue bonds up to the equivalent of an "AAA" rating, with the benefits of lower interest rates. Although the program has operated in relative obscurity over its 40 years of existence, the FHA has ... | 18,990,841 |
The relationship of educational preparation, autonomy, and critical thinking to nursing job satisfaction. | This descriptive correlational study explored factors influencing job satisfaction in nursing. Relationships between educational preparation, autonomy, and critical thinking and job satisfaction were examined. A convenience sample of 140 registered nurses was drawn from medical-surgical, management, and home health nur... | 18,990,891 |
Promoting critical appraisal of the research literature: a workshop for school nurses. | To promote healthy lifestyles and prevent youth obesity, school nurses collaborate with teachers and other professionals to implement effective health promotion activities (e.g., physical fitness initiatives and nutrition education). Critical appraisal of relevant, published literature is an essential competency for sc... | 18,990,892 |
Loss of confidence in diabetes management. | Using current treatment approaches, many patients with type 2 diabetes do not achieve glycemic goals--and do experience macrovascular complications that contribute to morbidity and mortality. It's time to consider other options. Aggressive therapeutic interventions aimed at insulin resistance and cell dysfunction may a... | 18,990,924 |
Out of Africa: traveller malaria in paediatric patients presenting to Our Lady of Lourdes Hospital Drogheda. | Malaria is one of the world's most important parasitic infections and is endemic in over 100 countries. The number of cases of malaria in Ireland has increased significantly over the last 10 years. The aim of this study was to retrospectively examine cases of paediatric malaria presenting to Our Lady of Lourdes Hospita... | 18,990,954 |
Skeletal dysplasias: 38 prenatal cases. | To assess the prenatal diagnosis of skeletal dysplasias in a single center over a ten-years period. All antenatal detected skeletal dysplasias during the period January 1st 1996 until December 31 2005 (10 years) were retrieved from the genetic database. This database includes all skeletal dysplasias where invasive pren... | 18,990,981 |
Scoliosis, blindness and arachnodactyly in a large Turkish family: is it a new syndrome? | In this report we have described an affected sib in a large Turkish family who appears to have a new distinct dominantly-inherited blindness, scoliosis and arachnodactyly syndrome. The combination of clinical abnormalities in these patients did not initially suggest Marfan syndrome or other connective tissue disorders ... | 18,990,988 |
Functional prefrontal reorganization accompanies learning-associated refinements in surgery: a manifold embedding approach. | The prefrontal cortex (PFC) is known to be vital for acquisition of visuomotor skills, but its role in the attainment of complex technical skills which comprise both perceptual and motor components, such as those associated with surgery, remains poorly understood. We hypothesized that the prefrontal response to a surgi... | 18,991,082 |
Revisiting the molecular structure of collagen. | The triple helix is a specialized protein motif found in all collagens. Although X-ray diffraction studies of collagen began in the 1920s, the very small amount of data available from fiber diffraction of native collagen caused the determination of its molecular conformation to take a very long time. In the early 1950s... | 18,991,083 |
Uniform partial dissolution of bone mineral by using fluoride and phosphate ions combination. | Mineral content is one of the main predictors of the mechanical properties of bone tissue. The contribution of the bone mineral phase to the mechanical properties of bone has been investigated by reducing the mineral content of bone with different in vitro treatment techniques such as hydrochloric acid (HCl), ethylened... | 18,991,086 |
Endothelin-1 does not change the function of monocyte-derived dendritic cells grown from patients with systemic sclerosis. | Systemic sclerosis (SSc) is characterized by both vasculopathy and autoimmunity. The interplay between these pathogenetic links requires further exploration. The aim was to assess the interrelationship of endothelin-1 (ET-1), a vasoconstrictor peptide, whose levels are usually elevated in the plasma of the patients wit... | 18,991,099 |
Thymulin, a thymic peptide, prevents the overproduction of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice. | The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria (LPS, 250 microg/100... | 18,991,101 |
A comparison of doubly hierarchical discriminant analyses for multiple class longitudinal data from EEG experiments. | This paper proposes a general and simple procedure that can be applied to establish classification rules for application to multiple-class longitudinal data. The procedure is applied to preclinical pharmaco-electroencephalogram (EEG) studies aiming at characterizing psychotropic drug effects on the basis of spectral EE... | 18,991,112 |
A threshold regression mixture model for assessing treatment efficacy in a multiple myeloma clinical trial. | A first-hitting-time (FHT) survival model postulates a health status process for a patient that gradually declines until the patient dies when the level first reaches a critical threshold. Threshold regression (TR) is a new regression methodology that incorporates the effects of covariates on the threshold and process ... | 18,991,113 |
Maternal sadness and adolescents' responses to stress in offspring of mothers with and without a history of depression. | This study examined maternal sadness and adolescents' responses to stress in the offspring (n = 72) of mothers with and without a history of depression. Mothers with a history of depression reported higher levels of current depressive symptoms and exhibited greater sadness during interactions with their adolescent chil... | 18,991,125 |
Own and friends' smoking attitudes and social preference as early predictors of adolescent smoking. | This study examined the role of friends' attitudes in adolescent smoking (N = 203). Growth mixture modeling was used to identify three trajectories of smoking behavior from ages 12 to 14 years: a low-rate group, an increasing-rate group, and a high-rate group. Adolescents' own and their friends' attitudes at age 11 yea... | 18,991,131 |
Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. | Currently, no agent has been confirmed as preventing the fibrosing progression of non-alcoholic steatohepatitis (NASH). In this study, rosiglitazone was used in the clinical treatment of insulin resistance in patients with type 2 diabetes mellitus. However, its protective effect on non-alcoholic fibrosing steatohepatit... | 18,991,162 |
Paralysis of the first dorsal interosseous muscle after external fixation of a distal radial fracture treated by transfer of the extensor indicis proprius tendon. | We describe a patient in whom the motor branch to the first dorsal interosseous muscle was injured by the pins of an fixator used to treat an unstable fracture of the distal radius. She was successfully treated by extensor indicis proprius transfer to the base of the proximal phalanx of the index finger. | 18,991,180 |
Sustained improvement of vascular endothelial function during anti-TNFalpha treatment in rheumatoid arthritis patients. | Vascular endothelial function and common carotid artery intima-medial thickness (CCA-IMT) are well-established surrogate markers for early atherosclerotic disease, which accounts for 30-40% of excess mortality in rheumatoid arthritis (RA) patients. Our aim was to investigate whether long-term treatment with anti-tumour... | 18,991,190 |
Language organisation in left perinatal stroke. | Right-hemispheric organisation of language has been observed following early left-sided brain lesions. The role of the site of damage is still controversial, as other aspects influence the pattern of speech organisation including timing of the lesion and the presence of epilepsy. We studied a group of 10 term-born chil... | 18,991,195 |
Factors influencing the prevalence of pulmonary nodules in lung cancer screening trials: re-evaluation of a CT study. | Numerous false positive findings are a problem in computed tomography based lung cancer screening trials. The potential patient-related variables that could predict the existence of such lung nodules were studied. 526 construction workers (age 38-81 yrs.) previously screened with spiral computed tomography were evaluat... | 18,991,240 |
Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids. | Today, eggs with an increased content of -3 fatty acids are available but there are few publications on the effects of consumption of such eggs on the lipoproteins and acute phase markers in humans. The aim of the present study was to evaluate the effects of consumption of standard eggs and -3 enriched eggs on lipoprot... | 18,991,244 |
Pregnancy-associated myocardial infarction: a report of two cases and review of the literature. | Myocardial infarction in pregnancy carries high morbidity. Spontaneous coronary artery dissection is one etiology of infarction, and up to one third of cases may arise in the third trimester of pregnancy or within three months postpartum. We report two cases of spontaneous coronary artery dissection, one at 34 weeks ge... | 18,991,245 |
Model for the reconfiguration of specialized vascular services. | This article built on previous work to develop an algorithm for elective abdominal aortic aneurysm (AAA) repair and carotid endarterectomy (CEA), with the aim of improving patient survival by regionalization of services. Vascular procedures were used as an example of specialized surgical services. A model was generated... | 18,991,256 |
Selecting variables in non-parametric regression models for binary response. An application to the computerized detection of breast cancer. | In many biomedical applications, interest lies in being able to distinguish between two possible states of a given response variable, depending on the values of certain continuous predictors. If the number of predictors, p, is high, or if there is redundancy among them, it then becomes important to decide on the select... | 18,991,258 |
TCR-beta chains derived from peripheral gammadelta T cells can take part in alphabeta T-cell development. | Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defic... | 18,991,270 |
Vibrational Raman optical activity of pi-conjugated helical systems: hexahelicene and heterohelicenes. | Helicenes constitute a special class of molecules combining helical conformation with pi-electron delocalization. These confer to helicenes specific chirooptical properties. In this article, we investigate the vibrational signatures thanks to the simulation of vibrational Raman optical activity (VROA) spectra. For that... | 18,991,298 |
Comparison of several testing strategies for combination drug efficacy trials based on the closure principle. | The author discusses three multiple testing procedures for identifying the minimum efficacious doses in a balanced factorial combination drug trial. All of these procedures utilize the closed testing principle, and hence strongly control the overall error rate and satisfy the coherence property, that is, if a hypothesi... | 18,991,315 |
Structural determination of atricins A and B, new triterpenes from Perovskia atriplicifolia, by 1D and 2D NMR spectroscopy. | Atricins A (1) and B (2), two new oleanane-type triterpenes have been isolated from the chloroform-soluble fractions of Perovskia atriplicifolia and their structures assigned from (1)H and (13)C-NMR spectra, Distortion Enhancement by Polarization Trasfer (DEPT) and by 2D-COSY, HMQC, Nuclear Overhauser Enhancement Spect... | 18,991,320 |
Determination of heteronuclear coupling constants from 3D HSQC-TOCSY experiment with optimized random sampling of evolution time space. | An application of 3D version of HSQC-TOCSY experiment for the measurement of heteronuclear coupling constants of organic compounds yielding complex spectra is proposed. The approach presented here is based on the optimized random sampling of the evolution time space followed by Multidimensional Fourier Transform (MFT).... | 18,991,321 |
Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition. | MicroRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression during development. This study was performed to determine gestational age-dependent changes in miRNA expression in the chorioamniotic membranes and to assess the significance of miRNAs in human pregnancy and parturition. The expre... | 18,991,333 |
Low-level laser irradiation promotes cell proliferation and mRNA expression of type I collagen and decorin in porcine Achilles tendon fibroblasts in vitro. | Achilles tendon problems are commonly encountered in sports medicine and low-level laser therapy (LLLT) is widely used in rehabilitative applications to decrease pain, reduce inflammatory processes, and promote tissue healing. This study examined the effects on the proliferation of porcine Achilles tendon fibroblasts a... | 18,991,342 |
Rheological characterization of the nucleus pulposus and dense collagen scaffolds intended for functional replacement. | Lumbar discectomy is an effective therapy for neurological decompression in patients suffering from sciatica due to a herniated nucleus pulposus (NP). However, high numbers of patients suffering from persisting postoperative low back pain have resulted in many strategies targeting the regeneration of the NP. For succes... | 18,991,343 |
Sedative and anticonvulsant drugs suppress postnatal neurogenesis. | Sedative and anticonvulsant drugs, which inhibit N-methyl-D-aspartate receptor-mediated excitation or enhance GABA-mediated action, may cause apoptotic neurodegeneration in the developing mammalian brain. Here we explored whether such agents influence early postnatal neurogenesis. The N-methyl-D-aspartate antagonist MK... | 18,991,352 |
Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. | Neurovascular niches have been proposed as critical components of the neural stem cell (NSC) response to acute central nervous system injury; however, it is unclear whether these potential reparative niches remain functional during chronic injury. Here, we asked how central nervous system inflammatory injury regulates ... | 18,991,353 |
Quantum dot-carrier peptide conjugates suitable for imaging and delivery applications. | We developed multifunctional fluorescent nanoparticles suitable for the nonviral delivery of negatively charged molecules like RNA. Therefore, we incorporated the recently developed branched hCT-derived carrier peptide hCT(18-32)-k7 on the surface of luminescent quantum dots (QDs). Besides detailed characterization of ... | 18,991,369 |
Synthesis of conformationally locked versions of puromycin analogues. | Conformationally locked North and South versions of puromycin analogues built on a bicyclo[3.1.0]hexane pseudosugar template were synthesized. The final assembly of the products was accomplished by the Staudinger-Vilarrasa coupling of the corresponding North (2 and 3) and South (6 and 7) 3'-azidopurine carbanucleosides... | 18,991,379 |
Structural changes of Salinibacter sensory rhodopsin I upon formation of the K and M photointermediates. | Sensory rhodopsin I (SRI) is one of the most interesting photosensory receptors in nature because of its ability to mediate opposite signals depending on light color by photochromic one-photon and two-photon reactions. Recently, we characterized SRI from eubacterium Salinibacter ruber (SrSRI). This protein allows more ... | 18,991,393 |
Methionine uptake in Corynebacterium glutamicum by MetQNI and by MetPS, a novel methionine and alanine importer of the NSS neurotransmitter transporter family. | The soil bacterium Corynebacterium glutamicum is a model organism in amino acid biotechnology. Here we present the identification of two different L-methionine uptake systems including the first characterization of a bacterial secondary methionine carrier. The primary carrier MetQNI is a high affinity ABC-type transpor... | 18,991,398 |
Behavior of thin films of poly(oxyethylene)-poly(oxybutylene) copolymers studied by brewster angle microscopy and atomic force microscopy. | Surface films of two copolymers of ethylene oxide (E) and butylene oxide (B), namely E23B8 and E87B18, have been examined by Brewster angle microscopy (BAM) and atomic force microscopy (AFM). Isotherms taken on unsupported films of these copolymers at the air-water interface showed a clear gas to liquid phase transitio... | 18,991,421 |
Effect of fluorescently labeling protein probes on kinetics of protein-ligand reactions. | We studied the effect of fluorescently labeling proteins on protein-ligand reactions. Unlabeled ligands (streptavidin-binding peptides and rabbit immunoglobulin G (IgG) as antigen targets) are immobilized on epoxy-functionalized glass slides. Unlabeled and Cy3-labeled protein probes from the same batch (streptavidin an... | 18,991,423 |
Computational study of the reaction of CH2(X3B1) with CH3OH. | The reaction of triplet methylene with methanol is a key process in alcohol combustion but surprisingly this reaction has never been studied. The reaction mechanism is investigated by using various high-level ab initio methods, including the complete basis set extrapolation (CBS-QB3 and CBS-APNO), the latest Gaussian-n... | 18,991,430 |
Metal ion-dependent fluorescent dynamics of photoexcited zinc-porphyrin and zinc-myoglobin modified with ethylenediaminetetraacetic acid. | The reconstituted zinc-myoglobin (ZnMb) dyads, ZnMb-[M(II)(edta)], have been prepared by incorporating a zinc-porphyrin (ZnP) cofactor modified with ethylenediaminetetraacetic acid (H(4)edta) into apo-Mb. In case of the monomeric ZnP(edta) cofactor coordinated by one pyridine molecule, ZnP(py)(edta), a spontaneous 1:1 ... | 18,991,435 |
Pyrazine in supercritical xenon: local number density defined by experiment and calculation. | Toward our goal of using supercritical fluids to study solvent effects in physical and chemical phenomena, we develop a method to spatially define the solvent local number density at the solute in the highly compressible regime of a supercritical fluid. Experimentally, the red shift of the pyrazine n-pi* electronic tra... | 18,991,436 |
Lewis acid catalyzed ring-opening intramolecular Friedel-Crafts alkylation of methylenecyclopropane 1,1-diesters. | The first Friedel-Crafts reaction initiated by the direct generation of a carbocation at the C3 position of MCP 1,1-diesters through distal-bond cleavage was presented. The described method supplied a new synthetic strategy to prepare indene and hydronaphthalene derivatives in moderate to excellent yields under mild co... | 18,991,443 |
Low-fouling, biofunctionalized, and biodegradable click capsules. | We report the synthesis of covalently stabilized hollow capsules from biodegradable materials using a combination of click chemistry and layer-by-layer (LbL) assembly. The biodegradable polymers poly(L-lysine) (PLL) and poly(L-glutamic acid) (PGA) were modified with alkyne and azide moieties. Linear film buildup was ob... | 18,991,459 |
Yoga for veterans with chronic low-back pain. | Chronic back pain affects a large proportion of both the general population and of military veterans. Although numerous therapies exist for treating chronic back pain, they can be costly and tend to have limited effectiveness. Thus, demonstrating the efficacy and cost-effectiveness of additional treatment alternatives ... | 18,991,515 |
Assessment of prescribed herbal medicine on liver function in Korea: a prospective observational study. | The aim of this study was to investigate the influence of herbal medicine (HM) prescribed by doctors of Korean medicine (KMD) on liver function in Korea. For this multicenter, prospective, observational study, we enrolled patients who wished to take HM prescribed by KMD for various medical purposes in Korea. One hundre... | 18,991,516 |
Epidemiology, management, and prognosis of secondary non-postoperative peritonitis: a French prospective observational multicenter study. | Despite improvements in treatment, secondary peritonitis still is associated with high morbidity and mortality rates. Better knowledge of real-life clinical practice might improve management. Prospective, observational study (January-June 2005) of 841 patients with non-postoperative secondary peritonitis. Peritonitis o... | 18,991,521 |
Combinatorial properties of graphs and groups of physico-chemical interest. | Combinatorial properties of graphs and groups of physico-chemical interest are described. A type of mathematical modeling is applied which involves "translating" algebraic expressions into graphs. The idea is applied to both graph theory and group theory. The former topic includes objects of importance in physics and c... | 18,991,574 |
Solution stability--plasma, gastrointestinal, bioassay. | Solution stability of drug candidates in plasma, gastrointestinal fluids and bioassays is important in order to achieve low clearance, good oral bioavailability and have robust SAR. Screening of solution stability early in drug discovery can avoid pursuing hits with high risk of instability, prioritize chemical series,... | 18,991,582 |
Permeability--in vitro assays for assessing drug transporter activity. | The accumulating evidence has revealed that drug transporters have essential roles in the delivery and excretory processes of drugs and their metabolites. Inhibition or induction of drug transporters can affect pharmacokinetic properties and therapeutic efficacy of a drug. Thus, the characterization of drug-transporter... | 18,991,588 |
Insights into the regulation of renal hemodynamic function in diabetic mellitus. | Diabetes mellitus (DM) is characterized by renal hemodynamic changes which have been purported to contribute to the development of nephropathy. In this review we have focused on the major renal hemodynamic factors that may be associated with glomerular hyperfiltration. Recent animal and human studies have demonstrated ... | 18,991,597 |
Environmental chemicals and breast cancer risk--a structural chemistry perspective. | In modern industrialized societies, people are exposed to thousands of naturally occurring and synthetic chemicals throughout their lifetime. Although certain occupational chemicals are known to be carcinogenic in humans, it has been difficult to definitively determine the adverse health effects of many environmental p... | 18,991,630 |
Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs. | Thyrotropin-releasing hormone (TRH), a hypothalamic orally active neuropeptide, has been manifested in a wide range of biological responses. Besides its central role in regulating the pituitary-thyroid axis by simulating the release of thyrotropin, TRH has considerable influence on the activity of a number of neurobiol... | 18,991,632 |
Steroid biosynthesis inhibitors in the therapy of hypercortisolism: theory and practice. | Cushing's syndrome is a rare disease with significant morbidity and mortality. Surgical intervention represents the most effective treatment option in both adrenocorticotropin-dependent and -independent forms of hypercortisolism. It is not uncommon, however, that surgery fails to cure or control the disease. Pharmacoth... | 18,991,633 |
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