title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
|---|---|---|---|
Application of reverse phase ion-pair partition chromatography to drugs of forensic interest. | A method is described for determining a wide range of abused drugs by using 1 column, a single isocratic system, and a fixed wavelength (254 nm) ultraviolet detector. Paired-ion chromatography is performed on a reverse phase muBondapak C18 column. Acidic, basic, and neutral drugs, including their corresponding salts, c... | 19,415 | [
-0.2743809,
0.2500725,
-0.3080601,
0.1428361,
0.01478131,
-0.172208,
-0.2849643,
-0.2008946,
0.4150126,
-0.1814032,
0.1462617,
-0.1078703,
0.4685067,
0.3696279,
-0.4006341,
-0.2610864,
-0.5211847,
0.1785669,
0.2896355,
0.03367289,
0.07129482,
0.1641929,
-0.1243667,
0.07... |
Metabolism of 6-aminonicotinic acid in Escherichia coli. | A late-log-phase culture of an Escherichia coli nadB pncA double mutant took up 6-[7-14C]aminonicotinic acid and excreted 6-[14C]aminonicotinamide. This mutant also accumulated intracellularly several radioactive compounds which have been tentatively identified as 6-amino analogs of compounds in the pyridine nucleotide... | 19,420 | [
-0.01394975,
-0.1482436,
-0.307028,
0.05297374,
0.2507295,
0.1958688,
-0.2316976,
-0.02406674,
0.1795546,
-0.001100807,
0.0671907,
0.08242715,
-0.006373041,
0.2160312,
-0.5090039,
0.1014171,
-0.1602647,
0.2956213,
-0.07105737,
0.0586748,
0.5138759,
0.4179421,
-0.003450247... |
Cyclic adenosine 3',5'-monophosphate regulation of membrane energetics in Escherichia coli. | Mutants of Escherichia coli K-12 lacking functional adenylate cyclase (cya) or the cyclic adenosine 3',5'-monophosphate (cAMP) receptor protein (crp) were compared with their wild type to evaluate the role played by the cAMP-cAMP receptor protein complex in regulating this organism's membrane-associated bioenergetic fu... | 19,422 | [
-0.2992753,
0.05921501,
-0.05764865,
0.1900066,
-0.28526,
-0.04350296,
-0.2511473,
0.3209581,
0.03096244,
-0.02516858,
0.1985137,
0.130932,
-0.128056,
0.1085826,
-0.5866806,
0.134445,
-0.09760119,
-0.4071081,
-0.1487569,
-0.2377755,
0.4654422,
0.0415,
-0.3421455,
-0.078... |
Alteration of the Bacillus subtilis glutamine synthetase results in overproduction of the enzyme. | A mutational leading to glutamine auxotrophy was located near a 5-fluorouracil resistance marker in the citB-thyA region of the Bacillus subtilis chromosome. This mutation resulted in a glutamine synthetase with altered kinetic and feedback properties. The specific activity of manganese-stimulated glutamine synthetase ... | 19,424 | [
0.09118673,
-0.2345459,
-0.1109598,
-0.05185622,
-0.1554486,
-0.2245204,
-0.1573847,
0.004304576,
-0.1375934,
0.1638084,
0.1722756,
0.2633741,
-0.2106111,
0.2457126,
-0.5291789,
0.2635142,
0.106331,
-0.001298801,
-0.2907868,
0.6517079,
0.6467349,
0.2829693,
-0.1225977,
... |
Dihydrodipicolinate reductases from Bacillus cereus and Bacillus megaterium. | Dyhydrodipicolinate reductases were purified 100-fold from crude extracts of B. cereus and B. megaterium and their properties were compared with those of the reductase from B. subtilis. The molecular weights of the reductases of B. cereus and B. megaterium were fount to be 155,000 and 150,000, respectively. These reduc... | 19,431 | [
-0.3644055,
0.2065827,
-0.1638529,
0.1742668,
-0.2318816,
-0.1537059,
-0.1091167,
0.1171568,
-0.248814,
-0.2130872,
0.3222196,
-0.001651558,
0.07382363,
0.4131868,
-0.679706,
-0.0152701,
-0.2823752,
0.2362851,
0.04760758,
-0.1097105,
0.1828331,
0.03607906,
-0.004993868,
... |
Accumulation of phosphoenolpyruvate in red cells incubated with the phosphate ester in an acidified isotonic sucrose medium. | Accumulation of exogenous phosphoenolpyruvate against the concentration gradient was observed when human red cells were incubated in an acidified isotonic sucrose medium. Fluoride increased the apparent accumulation by inhibition of the intracellular metabolic interconversion of the phosphate compound. The accumulatio... | 19,438 | [
-0.2513787,
0.1819679,
-0.2489228,
0.203984,
0.1503792,
-0.1775163,
-0.09862102,
0.2998735,
0.2738671,
0.04333337,
0.2008148,
0.09486911,
-0.2874734,
0.08612297,
-0.2108423,
-0.0283708,
-0.3666305,
0.02670278,
0.05543886,
0.06367162,
0.5113172,
0.1276723,
-0.150059,
-0.... |
A sensitive substrate for the clotting enzyme in horseshoe crab hemocytes. | An endotoxin-activated hemocyte lysate from horseshoe crab (Tachypleus and Limulus) was found to hydrolyze specifically BZ-Ile-Glu-Gly-Arg-p-nitroanilide, which was recently introduced as the substrate for assay of the blood coagulation factor, Factor Xa. Further, this amidase activity increased by increasing the conce... | 19,439 | [
-0.1701109,
-0.3039926,
-0.2223017,
0.1073705,
-0.4114575,
0.0404305,
0.1424877,
0.3056958,
0.1708611,
0.3213463,
-0.06440312,
0.3133789,
-0.0963341,
-0.03357826,
-0.3809155,
0.08810768,
-0.8412048,
0.1467464,
0.1002864,
0.4744971,
0.546149,
0.07199106,
0.07627162,
0.12... |
A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. | The rate of reaction of chloroacetaldehyde (0.039 M) with the "free" adenine residue in deoxyadenosine-5'-phosphate (dAMP) at pH 6.5 has been found to be nearly equal to that at pH 4.5. Practically 100% of the adenine is converted to a fluorescent product (epsilon-adenine residue) on incubation for 60 h at 37 degrees C... | 19,443 | [
-0.2197832,
0.06979807,
-0.2951376,
0.05991977,
0.2195515,
0.0356133,
-0.5205491,
0.3593984,
0.5808324,
-0.003272382,
-0.097553,
0.4592741,
0.2423019,
0.181461,
-0.2705998,
-0.01907653,
-0.24875,
0.1193341,
-0.2536078,
0.5372962,
0.3914643,
-0.1313844,
-0.2641681,
0.087... |
Interaction of thiolsubtilisin with Streptomyces subtilisin inhibitor, SSI. | Subtilisin BPN' was chemically converted to thiolsubtilisin and the interaction of this modified enzyme with Streptomyces subtilisin inhibitor (SSI) was examined. SSI competitively inhibited the esterolytic activity of thiolsubtilisin toward p-nitrophenyl acetate with a K1 value of 1.3 X 10(-5) M at pH 7.5 Spectrophoto... | 19,450 | [
-0.01801613,
-0.07547421,
-0.1749967,
-0.07075737,
-0.1423566,
0.20051,
-0.2184406,
0.005737728,
0.2821564,
-0.07465222,
0.05291801,
0.1348472,
0.007484925,
-0.1826811,
-0.53927,
0.07652543,
-0.2453195,
0.05182072,
0.07394775,
0.5454391,
0.02062268,
0.1984774,
0.03381715,... |
Properties of soluble rat brain histone lysine methyltransferase. | Histone-lysine methyltransferase has been solubilized from rat brain chromatin by repeated extraction with distilled water. The enzyme was further purified by chromatography on DEAE-cellulose and gel filtration. With chromosomal-bound histones as substrates, the enzyme methylated only the lysyl residues in histones H3 ... | 19,459 | [
-0.1356826,
0.3481964,
0.1543115,
-0.2756837,
0.1949632,
-0.166012,
-0.1497833,
-0.01303472,
-0.01741052,
0.1868446,
0.163459,
0.4560491,
0.2347279,
0.3204331,
-0.4228275,
0.349207,
-0.5220203,
0.09238849,
-0.07484063,
0.2727353,
0.2824464,
0.215176,
-0.2000486,
-0.0249... |
Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides. | Carbamyl-P synthetase (EC 2.7.2.9), aspartate transcarbamylase (EC 2.1.3.2), and dihydro-orotase (EC 3.5.2.3), the first three enzymes of the de novo pathway for synthesis of pyrimidine nucleotides, have been co-purified as a single oligomeric protein from a mutant line of hamster cells selected for its ability to resi... | 19,472 | [
-0.1488103,
-0.01335664,
-0.1450155,
-0.1921512,
0.08411659,
-0.3945789,
-0.4012436,
0.1462278,
0.1717944,
-0.01826595,
-0.02471104,
0.1583644,
0.08273163,
0.1901741,
-0.67584,
0.09741027,
-0.556857,
0.02556902,
0.168064,
0.4134872,
0.2170534,
0.3682384,
-0.3293991,
0.1... |
Effects of sugars on melanogenesis in cultured melanoma cells. | A permanent cell line C2M of mouse melanoma B16 was highly melanized in a modified Eagle's MEM supplemented with 10% calf serum, when the medium contained 1 mM galactose and 10 mM pyruvate instead of 5.5 mM glucose. The activity of the key anzyme for melanogenesis, tyrosinase (EC 1.14.18.1), of living cells cultured in... | 19,484 | [
-0.5311481,
-0.3310834,
-0.3239503,
-0.1125146,
0.00557545,
-0.1140881,
-0.1640571,
0.3712774,
0.1277626,
-0.3115767,
-0.1396022,
0.1898575,
0.03894488,
0.04805424,
-0.4179055,
0.0534923,
-0.3211662,
0.002503157,
-0.006257469,
0.2820587,
0.2584974,
0.2412917,
-0.4212774,
... |
Comparison of bumetanide and hydrochlorothiazide on renal potassium and hydrogen ion excretion. | The purpose of this study was to compare the renal electrolyte excretion pattern of bumetanide with that of hydrochlorothiazide in dogs anesthetized with pentobarbital. In bumetanide-treated animals, mean sodium excretion rose to 12 per cent of the filtered load, while hydrochlorothiazide increased sodium excretion to ... | 19,505 | [
-0.3944525,
0.299863,
-0.3479961,
-0.008322129,
0.1214827,
-0.3510208,
-0.05813724,
-0.2226784,
-0.3140292,
-0.1196254,
-0.01661949,
0.005872941,
0.2792239,
0.1590928,
-0.06477118,
-0.040187,
0.06530064,
0.1038786,
0.2448495,
0.1054668,
-0.07695322,
-0.1098,
0.06262844,
... |
Immune responses during measles infection in immunosuppressed Rhesus monkeys. | Rhesus monkeys immunosuppressed with horse anti-human thymocyte gamma-globulin (ATG) were infected with measles and simultaneously inoculated with sheep erythrocytes (SRBC), a thymus-dependent antigen, and with pneumococcal polysaccaride type III (SSS-III), a thymus-independent antigen. ATG treatment alone suppressed S... | 19,536 | [
0.007968797,
-0.269679,
-0.2476615,
-0.06167873,
-0.02778205,
-0.0467338,
-0.1768408,
-0.1543897,
0.0008008647,
0.1240562,
-0.0762405,
0.1270307,
0.01178295,
0.127018,
-0.1925803,
-0.03383496,
-0.2416714,
-0.1628974,
-0.01446666,
0.3350025,
0.1041579,
0.2127265,
-0.027515... |
Relations between ameboid movement and membrane-controlled electrical currents. | We have studied the pattern of electrical currents through amebas (mainly Chaos chaos) with an ultrasensitive extracellular vibrating probe. Amebas drive both steady currents and current pulses through themselves. Relatively steady current with an average surface density of 0.1-0.2 muA/cm2 enters the rear quarter of an... | 19,555 | [
-0.09378672,
-0.08538955,
-0.2947889,
-0.06579485,
-0.1027372,
-0.291177,
-0.3637453,
0.171928,
0.2516406,
-0.3546839,
-0.1364192,
-0.1836045,
-0.1034218,
0.253908,
-0.1493805,
0.03710756,
-0.5353362,
-0.2191502,
-0.1846875,
-0.1539656,
0.3734988,
0.0386024,
0.04177452,
... |
Temperature-dependent changes of chloride transport kinetics in human red cells. | Chloride self-exchange in human red cells was studied between 0 degrees C and 38 degrees C. At higher temperatures the flow-tube method was used. Although the general features of chloride transport at 0 degrees C and 38 degrees C are similar, the following differences were found: (a) the maximum pH of chloride self-exc... | 19,556 | [
-0.1461686,
0.07532101,
-0.3152475,
-0.005460541,
0.03566944,
-0.1044561,
-0.1329148,
-0.0585154,
-0.1827881,
0.0578744,
0.2749196,
0.2452978,
-0.07463545,
0.03566366,
-0.2341066,
-0.5107736,
-0.5116407,
-0.001759021,
-0.09642738,
0.5028352,
0.7493562,
0.4994722,
-0.03394... |
The effect of temperature on the tensile strength and disintegration of paracetamol and oxytetracycline tablets. | The tensile strengths and disintegration times of paracetamol and oxytetracycline tablets at room temperature are higher when they have been prepared at high temperatures, e.g. 85 degrees, than at room temperature or below, e.g.--20 degrees. The activation energies of the two materials, 3 and 1 k cal mol-1 (13 and 4kJm... | 19,574 | [
-0.1624998,
0.1855375,
-0.02612143,
0.07052486,
-0.2076414,
0.06534903,
-0.08850513,
-0.197896,
0.2809482,
-0.04747847,
0.07903446,
-0.2914835,
0.03124884,
0.3017606,
-0.652211,
-0.5323974,
-0.3395897,
0.056692,
-0.1111021,
0.2231198,
0.4161324,
0.0487086,
-0.3242335,
0... |
Fluorometric determination of nadolol in human serum and urine. | To determine nadolol, a new beta-adrenergic blocking agent, in serum and urine, the drug is extracted into n-butyl acetate or ether from alkaline potassium chloride saturated samples. After back-extraction into 0.1 N HCl, the drug is oxidized with periodic acid; the resulting aldehyde is coupled with o-phenylenediamine... | 19,616 | [
-0.208624,
0.2707011,
-0.3517455,
-0.09389436,
-0.006402819,
0.01962392,
-0.4389466,
0.2292357,
0.04439867,
-0.1666005,
0.1022826,
0.2644265,
0.3164385,
0.2406839,
-0.18602,
-0.2002497,
-0.4641524,
0.2890166,
0.02841018,
0.4338058,
0.1945655,
0.1299114,
-0.01730167,
0.0... |
An in vivo assay for the analysis of the biological potency and structure-activity relationships of narcotics: serum testosterone depletion in the male rat. | An in vivo method for the assessment of the agonistic-antagonistic activities and structure-activity relationships of the narcotics is described. The method, which is based on the depletion of serum testosterone levels by the narcotics in the male, satisfies all of the criteria necessary for a valid narcotic assay: 1) ... | 19,620 | [
0.1532655,
0.03636762,
-0.1714299,
-0.2458457,
0.1793745,
-0.1200735,
-0.3167364,
0.09239867,
-0.1183145,
-0.4427981,
-0.01095347,
-0.09708416,
0.3443366,
0.2135282,
-0.5465208,
0.1124637,
-0.6595785,
0.07916302,
0.09955812,
0.3359365,
0.1666619,
0.07847127,
0.05049367,
... |
[Constitutive synthesis of cellulase by Trichoderma lignorum]. | The induction of cellulase synthesis by lactose was studied in the resting cells of Trichoderma lignorum OM 534. The effect depended on the concentration of lactose, pH, and the age of the mycelium. The induction of the enzyme synthesis by lactose is supressed by glucose and its metabolites. The repression by glucose i... | 19,684 | [
-0.03370517,
-0.06843878,
0.1270969,
0.02041488,
-0.1017402,
-0.1104813,
-0.240908,
0.05095681,
0.3824934,
-0.0864784,
-0.09684594,
0.2606288,
-0.01610803,
0.4426957,
-0.5094066,
-0.07793523,
-0.4570913,
-0.266089,
-0.06472024,
-0.08061084,
0.7073009,
0.5405214,
-0.571942... |
The role of mineral surfaces in the origin of life. | Adsorption of nucleoside phosphates on the surfaces of volcanic rocks has been studied. Differences in the absorption of some nucleoside phosphates on the surface of basalt cinder have been found. Differences in the adsorption of similar molecules on different mineral surfaces have also been shown. Different adsorptive... | 19,721 | [
-0.05794637,
0.01645695,
-0.1691785,
0.3254239,
-0.07251304,
-0.2939722,
-0.6115677,
-0.01061505,
0.338729,
0.04127936,
-0.05914068,
-0.1316612,
0.2718807,
-0.2225894,
-1.099931,
-0.1109482,
-0.1281945,
0.06033724,
-0.2589799,
0.01839618,
0.2095758,
0.4018053,
-0.3798855,... |
An automatically balancing isolation amplifier for the decoupling of measuring systems with high impedances. | It is theoretically shown that different conditions of coupling and grounding cause error voltages with the simultaneous use of two high-impedance measuring systems (e.g. pH electrodes). By the use of special amplifiers using optical transmission systems these error voltages are prevented. The transmission characterist... | 19,727 | [
-0.1846025,
0.1950673,
-0.1806613,
0.1058201,
0.1159057,
-0.2528822,
-0.4093891,
0.1353788,
0.3360333,
-0.1115523,
0.06519108,
-0.2989209,
0.301382,
0.181741,
-0.3854054,
-0.2639214,
-0.4536536,
-0.1531468,
-0.2496604,
0.1641881,
0.01000211,
-0.1271175,
-0.07035128,
0.3... |
Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide. | The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte solutions containing high concentrations of formamide. Association rates to form DNA:DNA duplexes and DNA:RNA hybrids have been measured in these solvents. There is a temperature range in which DNA... | 19,730 | [
-0.1927778,
0.1324064,
-0.1835544,
-0.08478953,
0.1710202,
-0.01847759,
-0.5656907,
0.1656227,
0.2451103,
0.04882184,
0.001991268,
-0.01474706,
0.2898314,
0.1537535,
-0.1011247,
-0.3363869,
0.09804051,
0.1521203,
-0.1682832,
0.3883078,
0.4334263,
-0.3365976,
-0.3429463,
... |
The properties of native and denatured DNA in buoyant rubidium trichloroacetate at neutral pH. | Aqueous RbTCA is generally suitable as a buoyant solvent for both native and denatured DNA at neutral pH and room temperature. Native PM-2 DNA II, for example, is buoyant at 3.29 M salt, 25 degrees C; whereas the denatured strands band together at 4.52 M. Two properties of the solvent make this system uniquely useful f... | 19,731 | [
-0.07720815,
0.2176369,
-0.04544061,
-0.1353869,
0.09566104,
-0.1628105,
-0.4737363,
0.1259852,
0.3511672,
0.3870376,
0.1151947,
0.2162561,
-0.05994936,
-0.05711648,
-0.4032858,
0.158821,
-0.0753209,
0.2926289,
0.2848404,
0.4050212,
0.3446919,
0.05341569,
-0.2099724,
-0... |
Electrophysiological experiments on the mechanism and accuracy of neuromuscular specificity in the axolotl. | The supracoracoideus muscle of the axolotl shoulder girdle is innervated by two nerves, the supracoracoideus nerve (SC) supplying most of the muscle and the posterior supracoracoideus (PSC) supplying the posterior corner. All the muscle fibres are multiply innervated and at the border between the two innervations many ... | 19,787 | [
-0.1201343,
-0.2613723,
-0.3266989,
-0.3205689,
-0.3019881,
-0.187182,
-0.3686571,
0.2873124,
0.1612797,
0.00610306,
0.1984331,
-0.4820589,
0.1705762,
-0.0861371,
-0.1570298,
-0.2724103,
-0.5663296,
0.06903484,
-0.1887046,
0.3434562,
0.2428718,
0.03532261,
0.2892588,
-0... |
Negative naloxone effects in schizophrenic patients. | On the basis of the hypothesis that the opiate-like neuropeptides, such as beta-endorphin, may be involved in the etiology of schizophrenic symptoms, naloxone 1,2 mg and placebo were administered intravenously to 8 schizophrenic patients, using a double-blind, crossover design. Naloxone was not found to be different fr... | 19,807 | [
-0.1745154,
0.007333576,
-0.1689048,
-0.03675947,
0.1081736,
-0.3254651,
-0.3759551,
-0.2094242,
0.09481592,
-0.05307958,
-0.03420032,
0.4362307,
0.0245677,
0.3358418,
0.09921142,
-0.3065622,
-0.2070008,
0.05637493,
0.09650159,
-0.2335387,
-0.195555,
0.2319336,
-0.0366910... |
[Effect of methionine sulfone on the growth of Citrobacter intermedius C3 (author's transl)]. | Specific activity of glutamate dehydrogenase (GD) and glutamate synthase (GtS) has been determined in the wild strain C3 and on a non excreting pro- mutant strain. Methionine sulfone shows inhibitory effects on their growth. The addition of alpha-ketoglutarate to the medium prevents the inhibitory effect and increases ... | 19,817 | [
-0.07010572,
0.02963457,
-0.07695907,
0.1033961,
-0.1769963,
0.02714111,
0.08480084,
-0.3469768,
-0.2109745,
-0.1973027,
-0.2849781,
0.2982189,
-0.08071992,
0.5117607,
-0.7040864,
0.1365914,
-0.6461306,
-0.05980466,
-0.06558357,
0.3737717,
0.04743437,
0.1416424,
-0.000519... |
Red cell lysis coupled to the peroxidation of liver microsomal lipids. Compartmentalization of the hemolytic system. | As a contribution to the understanding of the mechanisms by which addition of erythrocytes to liver microsomes incubated in the NADPH dependent system results in hemolysis, experiments are presented here in which the system containing actively peroxidizing microsomes was separated from the system containing the red blo... | 19,823 | [
-0.1734979,
-0.09930176,
-0.1139324,
0.1317838,
0.09009451,
-0.1598974,
0.1041469,
0.190978,
0.0223551,
0.09956416,
0.1193439,
-0.07286545,
0.0751068,
0.2226532,
-0.2661368,
0.05973806,
-0.554207,
0.164249,
0.1615591,
0.2189409,
0.1623111,
0.3935021,
0.02268341,
0.08141... |
[Thermal inactivation and storage behavior of technologically important enzymes. IV. Spinach lipid-acyl-hydrolase]. | The thermal reaction of a lipid-acyl-hydrolase which seems to be important for the quality preservation of vegetable foods, was investigated in spinach. The authors applied a simple in-situ method using thin-layer chromatography which had been developed for the enzyme determination, to follow the thermal inactivation o... | 19,886 | [
0.112314,
0.05431359,
-0.1201581,
-0.04778473,
0.3050843,
-0.1232867,
-0.2100051,
0.1678813,
0.05765288,
-0.1903828,
0.3037827,
0.008224281,
-0.009536155,
-0.1698461,
-0.4821711,
-0.1711081,
-0.5722313,
0.1382278,
-0.001641375,
0.2388712,
0.4264103,
0.3634841,
-0.3470318,... |
[Thermal inactivation and storage behavior of technologically important enzymes. I. Horseradish and spinach peroxidase]. | The thermal inactivation and storage behaviour for horseradish and spinach peroxidases were investigated in defined systems, in spinach also within its natural environment. The inactivation curves of either enzyme show a sharp bend which is clearly visible at low, but not at higher temperatures. The D-values were taken... | 19,887 | [
0.1938994,
-0.1918064,
-0.2327673,
-0.09768958,
-0.01827997,
-0.3013879,
-0.06069726,
0.001891101,
0.1426554,
0.04109111,
0.3873717,
-0.004439219,
-0.1518976,
-0.1340973,
-0.3608699,
-0.03698872,
-0.5893686,
0.2732787,
0.2049156,
0.3168884,
0.3911791,
0.384575,
-0.2696605... |
[Several indices of the methylation process in schizophrenic patients]. | The paper deals with a study of 83 patients with different forms of schizophrenia and 15 normals where the methylating activity in converting nicotinamid into methylnicotinamid was determined and the activity of catechol-methyltransferase. In schizophrenic patients there is an increase of the methylating activity which... | 19,907 | [
-0.4301146,
0.4765501,
0.09868944,
-0.159128,
-0.05447982,
-0.1492978,
-0.4482854,
-0.1717644,
0.1261095,
0.1616659,
0.2045473,
0.006937241,
-0.1127648,
0.2766854,
-0.006127464,
0.2559783,
-0.4152833,
0.0982381,
-0.04128395,
0.2627605,
0.02151429,
0.1305492,
-0.1665846,
... |
Peripheral haemodynamics in essential hypertension. | Previous studies have indicated the existance of haemodynamically important structural vascular changes in patients and animals with hypertension. Possible pathophysiological implications of these changes are discussed. Two studies dealing with the question of reversibility of the structural changes on long-term blood ... | 19,929 | [
0.008307755,
0.1331051,
-0.1302389,
-0.07379501,
0.08762423,
-0.3996503,
-0.05617748,
-0.06666543,
0.09427218,
-0.07461566,
0.1450755,
-0.1464395,
0.06716817,
-0.0259992,
-0.6001025,
0.09216066,
-0.1373711,
0.2076373,
-0.336706,
0.464677,
-0.2723817,
0.05115739,
-0.097339... |
Prolactin release inhibiting and stimulating factors in the hypothalamus. | Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro. However, more work is needed to determine whether or not the effects of GABA or catecholamines on prolactin release are physiological or pharmacological. Until... | 19,952 | [
-0.08827421,
-0.05311956,
-0.07773535,
-0.1744266,
-0.01395762,
-0.2735334,
0.001787108,
-0.1292144,
-0.0148284,
-0.09899332,
0.08794453,
0.03636454,
0.1080468,
-0.1538433,
-0.1860094,
0.3194729,
-0.4862492,
0.291838,
0.01497882,
0.3445815,
-0.08769985,
0.1076543,
-0.0975... |
[Action of dibencozide on nitrogen metabolism in immediate and long-term postoperative resuscitation]. | The catabolic orientation of the immediate post-aggression phase is aggravated in neurosurgery by the almost routine prescription of corticosteroids. This emphasises the value of any treatment which might limit this orientation. The authors report their experience with the use of dibencozide, with its known facilitatin... | 20,005 | [
-0.276078,
0.1570674,
-0.02488494,
-0.4283997,
0.02042129,
-0.3695287,
-0.3752805,
-0.1773685,
-0.08398195,
0.3758779,
-0.1458907,
0.04011156,
-0.02179403,
-0.003475972,
-0.454315,
-0.2220683,
-0.1486759,
0.1179553,
0.181105,
0.3015019,
0.1258067,
0.1686181,
0.08958465,
... |
Extrinsic neural influences on gastrointestinal motility. | The gastrointestinal tract is capable of carrying on all its major functions after all extrinsic nerves have been cut. This automaticity is due to the local nervous mechanisms in the walls of the gastrointestinal tract and the inherent properties of the smooth muscles in its walls, and gastrointestinal hormones. All le... | 20,014 | [
-0.08440178,
-0.09760801,
-0.1138603,
-0.1491686,
0.07816344,
-0.2034059,
-0.2186695,
-0.008648507,
0.07539501,
-0.0099595,
0.2855611,
-0.3157829,
0.3426834,
-0.2265725,
-0.2834156,
0.09119894,
-0.826203,
-0.1060297,
0.02952214,
0.1343234,
0.03313041,
0.07159285,
-0.41272... |
Transovarial transmission of Rickettsia-like microorganisms in mosquitoes. | The wolbachiae found in Culex pipiens and the Tafahi strain of the A. scutellaris group are small rickettsia-like symbionts of the gonads. They are extrachromosomal self-replicating units that are vertically transmitted through the ovaries. Their presence in the only two groups of mosquitoes known to exhibit incompatib... | 20,018 | [
-0.1588309,
0.3144218,
0.2002595,
-0.1840517,
-0.1064958,
-0.2918734,
-0.1331919,
-0.05348608,
-0.03750633,
-0.1943357,
0.271454,
0.2647907,
-0.1467777,
-0.1691806,
-0.746595,
-0.2271821,
-0.5832107,
-0.1420058,
0.2186854,
-0.2548051,
-0.1764759,
0.1269406,
-0.1182713,
... |
Generalized glycogenosis in beef shorthorn cattle--heterozygote detection. | A preliminary study of acidic alpha-glucosidase in a variety of tissues was carried out in an attempt to develop a test which might be used to detect individuals heterozygous for the genetype associated with generalized glycogenosis in beef Shorthorn cattle. Of the tissues readily available peripheral lymphocytes were ... | 20,072 | [
0.04008051,
-0.4050101,
-0.1634607,
0.176502,
-0.003992973,
-0.09322596,
-0.2394682,
-0.05771593,
-0.3384224,
-0.1783209,
0.07289205,
0.2540191,
-0.007693394,
0.09855188,
-0.3341458,
-0.1160543,
-0.5072514,
0.2227695,
0.367878,
0.1758952,
0.2419849,
0.6039222,
0.000411534... |
The effect of mental arithmetic in normotensive and hypertensive subjects, and its modification by beta-adrenergic receptor blockade. | 1 The effects of a 5-min period of sustained mental arithmetic upon blood pressure and heart rate were determined in several groups of healthy subjects and hypertensive patients. 2 The arithmetic produced significant increases in heart rate and blood pressure (both systolic and diastolic) in both normotensive and hyper... | 20,124 | [
-0.2125311,
0.2459928,
-0.4342994,
-0.2245579,
0.09909002,
-0.2392902,
-0.2177443,
-0.07734696,
-0.02664082,
-0.06901365,
0.06881579,
0.2000805,
-0.06448506,
0.421622,
-0.3886276,
-0.1013591,
-0.2702102,
0.2326784,
-0.06906076,
0.2275771,
0.1002169,
0.001049717,
-0.143394... |
Magnetic resonance investigation of ionizable residues at the active site of thermolysin. | The details of the pH dependence of the thermodynamic and magnetic interactions of the active-site region of thermolysin in which manganese has replaced the active-site zinc atom and the inhibitor N-trifluoroacetyl-D-phenylalanine have been examined. These show a number of ionizable groups in the active-site region. A ... | 20,127 | [
0.00628308,
0.009683949,
-0.2930795,
0.0815203,
-0.2091901,
0.01257201,
-0.05761037,
0.04585556,
-0.05726756,
0.3290099,
0.02460085,
0.2148638,
0.1385924,
-0.2386091,
-0.3115715,
0.06707219,
-0.2388235,
0.01658173,
-0.2617206,
0.5224788,
0.226184,
0.0798554,
-0.1923006,
... |
Dissociation of growth hormone and prolactin response to levodopa during pyridoxine administration. | 500 mg of levodopa was administered orally to 8 normal subjects and induced an increase of growth hormone (GH) and a decrease of prolactin (PRL) secretion. The levodopa-induced GH release was inhibited by an intravenous infusion of pyridoxine; on the contrary, the PRL response to levodopa was enhanced by pyridoxine inf... | 20,170 | [
-0.137532,
-0.3174568,
-0.1532787,
-0.2067388,
0.4646285,
-0.2355597,
0.1042118,
-0.2149054,
-0.2434246,
0.1705225,
0.1218242,
0.1960638,
-0.1136598,
0.06002351,
-0.4937757,
0.02410248,
-0.4023051,
0.1270275,
-0.2479169,
0.2823469,
0.1488421,
0.1607501,
0.1204805,
-0.07... |
The uptake and overflow of radiolabelled beta-adrenoceptor blocking agents by the isolated vas deferens of the rat. | 1. A comparison of uptake into and overflow from the isolated vas deferens of the rat has been made between [3H]-noradrenaline ([3H]-NA), [14C]-D-sorbitol and three radio-labelled beta-adrenoceptor blocking agents, [14C]-practolol, [14C]-(+/-)-propranolol and [3H]-penbutolol. 2. The accumulation of [3H]-NA after 30 min... | 20,192 | [
0.05297507,
-0.03349578,
-0.3416014,
-0.2877131,
0.0815495,
-0.3372011,
-0.2030247,
-0.2145509,
-0.3647019,
-0.4721218,
0.08885307,
0.1966582,
-0.135211,
-0.1138258,
-0.464624,
-0.08120515,
-0.3925384,
0.2687814,
0.03831215,
-0.03552252,
0.4118752,
0.3115149,
-0.04115509,... |
Proximal-distal absorptive gradients in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats. | Using a single-pass perfusion technique, H2O, Na+, Cl-, HCO3-, and glucose absorption were studied in the jejunum and proximal and distal ileum of rats either uninfected or infected with a tapeworm parasite (Hymenolepis diminuta). The effect of parasitization, region of the intestine, type of buffer, and concentration ... | 20,212 | [
0.05335982,
-0.351485,
-0.1153731,
0.1298332,
-0.1253164,
-0.4757452,
-0.3943575,
-0.1900026,
-0.1733113,
-0.1018987,
0.2099963,
-0.2481233,
-0.09081229,
-0.1989928,
-0.3924355,
-0.3492784,
-0.4140401,
-0.1630103,
-0.1249295,
-0.07100231,
0.1388073,
-0.03840474,
0.0606240... |
Adult height of patients treated in childhood for undescended testes. | 101 patients successfully treated for undescended testes with human chorionic gonadotrophin (HCG) or with HCG followed by surgery reached normal adult heights. Deviations from normal growth in individual patients did not appear to be related either to their earlier undescended testes or to the successful therapy, but r... | 20,309 | [
-0.2056414,
0.01060461,
-0.2734319,
-0.08408165,
0.1629234,
-0.1822337,
-0.5372172,
-0.03652829,
-0.1156714,
0.03924368,
0.5286402,
0.2403733,
-0.201543,
0.078931,
-0.3066513,
-0.01303475,
-0.09490267,
-0.1720145,
-0.2005467,
-0.1005322,
0.3810071,
0.1926215,
-0.08398887,... |
Adult metachromatic leukodystrophy. I. Clinical manifestation in a female aged 44 years, previously diagnosed in the preclinical state. | In a 5-year follow-up of a case of adult metachromatic leukodystrophy, already diagnosed in the preclinical stage, the development of the symptoms of this disease could be studied in detail: initially, lack of drive, emotional lability and depressive mood. At the same time, pain in the arms and beginning gait disturban... | 20,310 | [
-0.074036,
-0.2551345,
-0.1426516,
-0.2054739,
-0.0692524,
-0.5789572,
-0.1366856,
0.1421834,
-0.3920694,
-0.1085578,
0.1730479,
0.2673592,
0.01286008,
0.005364001,
-0.1696785,
0.3910532,
-0.2763605,
-0.03297216,
-0.2099991,
0.08116756,
0.2003756,
0.00113756,
0.03888907,
... |
The problem of sea urchin egg fertilization and its implications for biological studies. | The analysis of sea urchin egg fertilization shows that several phenomena common to other biological systems are involved: cell recognition, cell fusion, exocytosis and initiation of mitotic activity. Both the role of calcium ions in cell fusion and exocytosis and the function of the cell surface in the initiation of m... | 20,321 | [
0.02946653,
-0.1802975,
-0.008264476,
0.0299703,
0.04761934,
-0.2007489,
-0.1231664,
0.1579975,
0.2296302,
-0.09480365,
0.0261558,
-0.04780837,
-0.3738761,
0.02749742,
-0.5187064,
-0.2064154,
-0.1980965,
0.2089258,
-0.08378262,
0.03984847,
0.3906186,
0.2365795,
-0.1280102... |
The clinical efficacy of the repeated transcervical instillation of quinacrine for female sterilization. | The safety and efficacy of the repeated transcervical instillation of quinacrine hydrochloride in a suspension of 5 ml of 2% Xylocaine was evaluated in 200 patients. All instillation procedures were performed during the proliferative phase of the menstrual cycle: the second instillation was made in the first menstrual ... | 20,347 | [
-0.3067231,
0.1826005,
-0.2652669,
-0.1086766,
-0.06958763,
-0.4557033,
-0.257938,
-0.2272062,
0.09018429,
0.03512606,
-0.08018714,
-0.1004982,
-0.006969285,
0.45912,
-0.04298359,
-0.196883,
-0.09243725,
-0.2613893,
-0.4719519,
-0.1677053,
0.3141179,
0.4329355,
-0.119263,... |
Interrelationships between histamine, prostaglandins, and cyclic AMP in gastric secretion: a hypothesis. | Based on the current experimental evidence, a model is proposed for mutual interactions of histamine, prostaglandins, and cyclic AMP in regulation of gastric secretion and pathogenesis of peptic ulcer. Histamine acting on H2-receptor-associated adenylate cyclase stimulates cyclic AMP formation and consequently secretio... | 20,385 | [
-0.2630243,
-0.2484504,
-0.04951765,
0.01892462,
0.3444656,
0.00192358,
0.06194037,
0.087571,
0.09894178,
0.2887927,
0.03860827,
0.06717835,
-0.1184981,
-0.04196522,
-0.4877676,
0.1999321,
-0.07065151,
0.01481858,
-0.0223666,
-0.01391599,
0.2800919,
0.04990797,
-0.1595286... |
Gastric adenosine triphosphatases: a review of their possible role in HCl secretion. | In the search for gastric ATPases that might be related to the mechanism of HCl secretion, an interesting and rather unique K+-stimulated ATPase has been discovered. This enzyme is isolated from oxyntic cells and has been associated with the apical plasma membrane and/or tubulovesicular system. Membrane vesicles contai... | 20,386 | [
-0.4389244,
-0.3633049,
-0.1942053,
0.08103234,
0.2287449,
-0.04000639,
0.1823599,
-0.03931582,
-0.1118091,
0.1090623,
0.2313499,
0.171639,
-0.1115752,
0.2116366,
-0.7576183,
0.2274317,
-0.5609715,
0.4173372,
0.2084636,
-0.1924087,
0.6162255,
-0.01269753,
-0.05512375,
0... |
[Drug effects on blood pressure and heart rate in unanesthetized animals. (1). Effects of beta-blocking agents (author's transl)]. | beta-Blocking actions of orally administered Kö 1400 and tiprenolol, new beta-blocking agents, were studied in unanesthetized rats and dogs, using a fall of blood pressure and an increase in heart rate produced by isoproterenol as a measure of beta-receptor activation. Blood pressure was recorded from the aorta of the ... | 20,392 | [
0.07478161,
-0.2265567,
-0.3152976,
-0.270124,
-0.007864899,
-0.212534,
-0.2943229,
-0.1033651,
0.03725757,
-0.1997931,
0.0526165,
-0.04219727,
0.1990833,
-0.2232539,
-0.4316092,
-0.1113046,
-0.5031919,
0.3808005,
0.2423025,
0.05494229,
-0.01024967,
0.2321444,
-0.1048353,... |
Mixed lymphocyte culture responses in infertile couples. | Twenty couples suffering from unexplained infertility have been tested in mixed leucocyte culture to determine if the wives were preimmunized against their husbands. The wives were tested against their husbands and four unrelated persons, and thymidine incorporation was measured on the third and fifth days of culture. ... | 20,410 | [
0.0009350183,
0.05805803,
0.0453979,
0.06688723,
0.3726852,
-0.05799409,
-0.08809247,
0.2221659,
0.1353875,
0.09420149,
-0.02503777,
0.406202,
0.01648409,
0.3251681,
-0.3192463,
-0.163256,
-0.6006221,
-0.001991404,
-0.4633032,
0.08600078,
0.1992651,
0.07134516,
-0.0635558... |
The contractile basis of amoeboid movement. V. The control of gelation, solation, and contraction in extracts from Dictyostelium discoideum. | Motile extracts have been prepared from Dictyostelium discoideum by homogenization and differential centrifugation at 4 degrees C in a stabilization solution (60). These extracts gelled on warming to 25 degrees Celsius and contracted in response to micromolar Ca++ or a pH in excess of 7.0. Optimal gelation occurred in ... | 20,447 | [
-0.3148487,
0.1683599,
-0.3250172,
-0.2423523,
0.03188921,
-0.04831528,
-0.3527741,
0.02526644,
0.2141,
-0.1201728,
-0.04237173,
-0.07512202,
-0.1514679,
-0.05193936,
-0.1875162,
-0.1555615,
-0.6512998,
0.06755921,
0.005193376,
0.4259598,
0.4750765,
0.2127875,
-0.0508553,... |
Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. | In an earlier report from this laboratory, one of the early manifestations of hypervitaminosis A was shown to be a marked stimulation of hepatic gluconeogenesis. In the present study, effects of feeding 30,000 IU of retinyl palmitate to young rats (80-100 g), once daily, for 2 days on the incorporation of 14C-labeled p... | 20,486 | [
0.007820193,
-0.4891583,
-0.4378434,
0.3026126,
0.1235074,
-0.4246575,
0.192111,
-0.01273279,
-0.3254439,
0.009175868,
0.2708734,
0.1203573,
-0.05549432,
0.1714716,
-0.1599125,
0.4909561,
-0.3334388,
0.04685444,
0.02381888,
-0.09727225,
0.3236739,
0.6089797,
-0.1564173,
... |
Specific binding sites for a parvovirus, minute virus of mice, on cultured mouse cells. | The early interactions between parvoviruses and host cells have not been extensively described previously. In this study we have characterized some aspects of viral binding to the cell surface and demonstrated the existence of specific cellular receptor sites for minute virus of mice (MVM) on two murine cell lines that... | 20,517 | [
-0.350528,
-0.2588776,
-0.4340166,
-0.08076372,
0.1933575,
0.2357303,
-0.274772,
0.1930518,
0.004303151,
0.1359888,
-0.212331,
0.2142284,
0.00002912307,
-0.1523927,
-0.1979003,
-0.2967483,
-0.2991779,
0.000652746,
-0.05411975,
0.3118919,
0.6005446,
0.04884768,
-0.1369005,... |
[Oospora lactis strain actively producing lipase]. | Morphological, cultural and physiological properties of the fungus Oospora lactis producing lipase are described. The activity of lipase depends on the composition of a growth medium, pH, temperature, the duration of cultivation. Optimum conditions for lipase biosynthesis by the fungus have been found. The strain produ... | 20,556 | [
0.1238441,
-0.4677359,
-0.02616327,
-0.05593736,
-0.1316613,
-0.1418699,
-0.09806392,
0.07232527,
-0.04414123,
0.02741779,
-0.1767378,
-0.2907234,
0.01490194,
0.03495356,
-0.6193541,
0.02587072,
-0.4237739,
0.1756119,
0.2562456,
0.3569677,
0.7614676,
0.2565411,
-0.0201764... |
[Determination of acid-base parameters by means of programmable pocket calculators (author's transl)]. | The possibility to calculate parameters of acid-base status derived by common laboratory devices without built-in computers is described. The calculation is carried out faster and more exactly than it is possible by nomograms, which is especially suitable when a great quantity of dates occurs. The number of programmabl... | 20,561 | [
0.04435828,
0.02453407,
-0.2847061,
0.00594731,
0.05333038,
-0.2487608,
-0.2925583,
0.0760492,
-0.01594168,
0.1196909,
-0.07478787,
0.06944347,
0.3221653,
0.1955334,
-0.440663,
-0.1787777,
0.1629344,
0.2923609,
0.1578715,
0.3214945,
0.4836729,
-0.2279218,
-0.03793785,
0... |
Aminoacyl-tRNA synthetases from calf liver: optimized assay conditions and kinetic properties. | Kinetic studies have been performed on the "family" of aminoacyl synthetases from calf liver. All assays were based on the esterification of amino acids to tRNA. Optimized reaction conditions for each synthetase are reported. Most of the synthetases show hyperbolic kinetics with respect to both amino acid and tRNA conc... | 20,569 | [
-0.0168028,
0.01936196,
-0.3678358,
0.1026288,
0.1188354,
-0.3158722,
-0.1986273,
0.2543507,
-0.0322407,
-0.04223074,
-0.09540521,
-0.0615425,
0.1049343,
0.4667173,
-0.3374262,
0.08722607,
-0.2109985,
0.0655956,
-0.2735071,
0.2887371,
0.2708995,
0.05175799,
0.02505324,
... |
The role of the AT pairs in the acid denaturation of DNA. | It has been determined previously that the protonation of the GC pairs induces a DNA conformation change which leads to a "metastable" structure. The role of the AT pairs, however, is no well known because the protonation does not modify their spectral properties. By means of an indirect method based on the binding of ... | 20,604 | [
0.04417593,
0.02668627,
-0.08578895,
-0.04517437,
0.3580962,
-0.05267162,
-0.1381161,
-0.1013869,
0.3609506,
0.02611411,
-0.09596822,
0.1226677,
0.2058129,
-0.03176526,
-0.5620522,
-0.3056642,
-0.02324332,
0.1329301,
0.1844294,
0.2848473,
0.3648879,
-0.1434454,
-0.3489804... |
Kinetics of drug decomposition. Part 45. Logk--pH profile for rolitetracycline degradation. | UV spectrophotometry and fluorometry were applied for an examination of rolitetracycline (RT) degradation at pH's ranged from ca 0-8 to 13-0. It was demonstrated that these methods enable to follow the rate of degradation of tetracycline formed in the course of RT hydrolysis. However, they do not allow to monitor the h... | 20,611 | [
-0.1485938,
0.1035107,
-0.3519259,
-0.1488947,
-0.1259272,
-0.2611543,
-0.1452121,
0.09052753,
0.2991847,
-0.1338711,
0.3291023,
0.1856975,
0.0808927,
0.363492,
-0.4810111,
-0.06360913,
-0.1846606,
0.2273156,
-0.3266638,
0.385316,
0.5179017,
0.3598906,
0.06542226,
0.055... |
Purification and properties of a ribonuclease in human urine that hydrolyses polycytidylic acid. | Human urine RNase was purified about 2000-fold. The preparation is free from phosphatase, phosphodiesterase and DNase activities. On electrophoresis through polyacrylamide gel at pH 8.3, it migrates toward the anode and stains with periodic acid-Schiff reagent, suggesting that it is acidic and glycoprotein in nature. I... | 20,615 | [
-0.07769837,
-0.06367827,
-0.2614454,
0.1729474,
0.2085668,
-0.1020549,
-0.2683317,
-0.1230823,
0.2068467,
0.05635837,
0.1459591,
-0.01203015,
0.008657102,
0.2012604,
-0.01127259,
0.07255387,
-0.3499393,
-0.1368735,
0.272213,
-0.08205324,
0.2302295,
0.08338955,
-0.2671005... |
Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides. | Guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] activity of human platelet homogenates was stimulated by the addition of phospholipase A2 or unsaturated fatty acids such as oleic, vaccenic, linoleic, linolenic, eicosenoic, eicosadienoic, and arachidonic acids. The addition of lipoxidase potentiated ... | 20,630 | [
-0.2874423,
-0.004308315,
-0.2623828,
-0.1788237,
0.06095097,
-0.09404067,
-0.1412101,
-0.06148586,
-0.115159,
-0.06647208,
0.1550594,
0.1279231,
-0.1517017,
0.01454302,
-0.1479334,
0.2040006,
-0.5257557,
0.1143322,
0.288379,
0.3726061,
0.372811,
0.4129889,
-0.3926864,
... |
[The effect of sympathomimetric drugs on exocrine pancreatic function. Studies in the isolated cat pancreas (author's transl)]. | This study reports on effects of beta-sympathomimetic drugs on the exocrine function of the isolated cat pancreas. The injection of these drugs resulted in an increase of pancreatic protein and enzyme secretion, the excretion of calcium into the juice and the rate of volume output were not changed. The enzyme secretion... | 20,653 | [
0.1864343,
-0.2547621,
-0.2226474,
0.0576346,
-0.4497946,
-0.3938015,
-0.0461529,
-0.1418835,
-0.09327832,
0.03241104,
0.2757383,
0.138769,
0.02529351,
0.03622653,
-0.4317649,
-0.07672288,
-0.4370193,
0.2587355,
0.2239704,
0.2318189,
-0.2215239,
0.1511925,
0.07110079,
-... |
[Characteristics of the ecology of the eastern equine encephalomyelitis virus in the Republic of Cuba]. | Virologic and serological surveys of wild vertebrates carried out in various provinces of Cuba demonstrated definitely that birds were the main hosts of eastern equine encephalomyelitis (EEE) virus in this territory. Fifteen strains of this virus were isolated from 8 species of birds belonging to 5 orders. Isolation of... | 20,693 | [
-0.03876467,
-0.1391189,
0.4463246,
-0.2096825,
-0.1278108,
-0.2871119,
-0.3228142,
-0.01644591,
-0.2635257,
-0.1544785,
-0.05923508,
0.08555618,
0.09300557,
-0.2657902,
-0.3665245,
-0.1867356,
-0.009830471,
0.2206835,
0.3282469,
0.2051329,
0.1369916,
0.1242173,
-0.257276... |
Gamma-radiolysis of aqueous solution of histidine. | The dependence of Gi(-M) values of histidine on the concentration of irradiated 10(-4) - 10(-1)M solutions, pH and the presence of O2, N2O and sec-butyl alcohol was investigated. In oxygen-free medium the maximum radiation sensitivity of histidine was found at pH 5--8; in oxygenated solutions it was shifted to the 6--1... | 20,705 | [
-0.1050101,
-0.2387471,
-0.4257134,
0.1843764,
-0.2313575,
-0.1339069,
-0.2296796,
-0.3945746,
0.01761331,
0.07887317,
0.03017514,
-0.08794481,
-0.05054065,
-0.06730491,
-0.6035682,
-0.3019532,
-0.275844,
0.3120095,
0.09397963,
0.4274744,
0.3581114,
0.1975455,
0.1039676,
... |
Diazepam and flunitrazepam as induction agents for cardiac surgical operations. | Diazepam and flunitrazepam were compared in equipotent doses as induction agents for premedicated patients having cardiac surgery. Both drugs caused a significant fall in arterial blood pressure, a rise in Paco2 and a fall in Pao2. There was no significant difference between the two drugs in onset time of anaesthesia, ... | 20,727 | [
-0.3019056,
-0.0980593,
-0.299579,
-0.3933716,
-0.09615249,
-0.3567208,
-0.5617497,
0.07911536,
-0.04771095,
-0.04828077,
0.3174423,
0.2247997,
-0.06518266,
-0.2396198,
-0.1468383,
-0.01795579,
-0.1764865,
-0.08093154,
0.2147216,
0.2118214,
-0.3545322,
0.1865267,
-0.15813... |
Protected proteins in ruminant nutrition. In vitro evaluation of casein derivatives. | Chemical treatment of proteins in feeds can, by crosslinking protein chains or other chemical effects, decrease their solubility and microbial degradation in the rumen. A need exists to modify proteins systematically under well-defined conditions with inexpensive reagents and to evaluate the treated products nutritiona... | 20,754 | [
0.0165673,
-0.04206915,
0.2341909,
-0.1008017,
-0.080873,
0.02984227,
0.1335032,
0.286108,
0.2668035,
-0.1449023,
0.1335744,
-0.3397526,
0.1439621,
0.1833597,
-0.3772531,
0.1771531,
-0.3575667,
0.0177578,
-0.01663145,
0.1421259,
-0.2949978,
0.2788261,
-0.1405063,
0.0159... |
[Continuity of life situation and "successful" aging (author's transl)]. | The determinants of "successful" aging have been a main concern in social gerontological research. The Continuity Hypothesis suggests that there is a relationship between an older person's life satisfaction and the similarity of his social life situation in middle adulthood and in old age. The old person is the more li... | 20,790 | [
-0.1101484,
-0.1210937,
0.0358173,
0.1904111,
0.1506864,
-0.1832386,
-0.3046337,
0.2953089,
-0.138077,
-0.1190049,
-0.0724945,
-0.02976021,
-0.1447263,
-0.5924937,
-0.5282643,
-0.3236389,
-0.1944416,
0.2127471,
-0.1499587,
0.1682035,
0.4123128,
0.102636,
0.2655447,
0.05... |
[Importance of space analysis of U-moment-vectors concerning ageing people and chronical heart and blood circulation diseases (author's transl)]. | U-vectors are a stabil component of electric activity of the heart repolarisation. The examinations of the space sizes and direction of the U-moment-vectors give an idea about the character of repolarisation of Purkinje's fibres and papillar muscles in old age and in chronical heart and blood circulation diseases. Path... | 20,802 | [
-0.1530185,
-0.2812619,
-0.3882386,
0.03922509,
0.2100266,
-0.4336266,
0.1579731,
0.08822944,
0.04228909,
0.2411835,
-0.0001240019,
-0.148302,
0.0849415,
0.1832217,
-0.6115494,
-0.1161523,
0.07197169,
0.2177486,
-0.4870837,
0.05927607,
0.462871,
0.1787304,
0.01558844,
0... |
[Morphological changes of the female urinary bladder in the elderly. Chronic infections of the urinary tract; the importance of their intensive treatment as preparatory measure for rehabilitation (author's transl)]. | The urinary bladder of the elderly is showing a reduced adaptability on account of morphological changes; it is therefore more prone to infections. The morphological changes consist in a reduction of muscle fibres and in an increase of collagen fibres and in elastosis, furthermore in a sklerosis of the intramural arter... | 20,805 | [
-0.005977794,
-0.04448756,
0.1756627,
0.2213049,
0.01541348,
-0.3969808,
-0.07214519,
0.07665674,
0.1522009,
0.3104256,
0.225511,
-0.1891824,
-0.06297258,
-0.1518523,
-0.6588625,
-0.1174622,
-0.2972209,
0.1112602,
-0.3347061,
0.1113755,
-0.06596,
-0.2034813,
0.02133855,
... |
Experimental cryptorchidism in adult male rats: histological and hormonal sequelae. | Mature male rats were rendered cryptorchid and followed for up to nine weeks during which serial blood specimens were obtained for multiple hormonal analyses; serial testicular samples were obtained as well. In contrast with control animals, cryptorchid rats showed transient rises in FSH which returned to normal at the... | 20,820 | [
0.1410443,
0.1190609,
-0.1880982,
-0.1678838,
0.1604007,
-0.5256664,
-0.3346334,
0.236995,
-0.1035265,
0.1835893,
0.2827912,
0.2859554,
-0.1771335,
-0.03625147,
-0.4863447,
-0.1531555,
-0.1118684,
-0.2732323,
0.0335444,
0.1683673,
0.1902467,
0.3549749,
0.01432529,
-0.19... |
Cilioinhibitory effect of phenothiazines in vitro and its antagonism by Ca++. | The inhibition of ciliary beating in vitro by physiologic concentrations of chlorpromazine (CPZ) and prochlorperazine (PCP) was demonstrated in two experimental systems. CPZ had a greater cilioinhibitory effect than PCP on the rotational velocity of tissue explants from the frog palate in amphibian Ringers, and on the ... | 20,858 | [
-0.1050541,
-0.3452117,
-0.3192253,
-0.1345609,
0.02580041,
-0.04603672,
-0.4946253,
0.337848,
0.2856266,
0.02155117,
0.1374053,
0.3593005,
0.0604194,
0.1004164,
0.08737043,
-0.04465328,
-0.741334,
-0.1170353,
-0.1869304,
0.03627462,
0.4957875,
0.06790566,
0.04035487,
-... |
The effect of inorganic phosphate on cyanogenesis by Pseudomonas aeruginosa. | The biosynthesis of hydrogen cyanide (HCN) by a strain of Pseudomonas aeruginosa is found to be significantly influenced by inorganic phosphate. Optimum HCN production occurs when the phosphate concentration is between 1 and 10 mM. Above and below this concentration the amount of HCN produced decreases sharply and at 0... | 20,863 | [
-0.1341106,
-0.2378402,
-0.1837501,
0.1357139,
-0.1187205,
0.1192164,
-0.2602331,
0.2541896,
-0.1870326,
-0.1786361,
0.1434579,
0.1971896,
-0.3098181,
-0.03825582,
-0.5540523,
-0.1800429,
-0.1206787,
0.2034341,
-0.02987929,
0.006414378,
0.1538004,
0.2527444,
-0.07783762,
... |
An NADP-linked acetoacetyl CoA reductase from Zoogloea ramigera. | Zoogloea ramigera I-16 M was found to contain two stereospecific acetoacetyl CoA reductases; one was NADP+-linked and D(-)-beta-hydroxybutyryl CoA specific and the other was NAD+-linked and L(+)-isomer specific. The NADP+-linked enzyme, purified approximately 150-fold, had a pH optimum for the reduction of acetoacetyl ... | 20,866 | [
-0.01408465,
-0.1008472,
0.1169433,
0.2908394,
-0.1919955,
-0.4373781,
-0.3087015,
0.2402055,
0.03320781,
-0.07704517,
-0.02077666,
-0.1075259,
-0.1202821,
-0.06440359,
-0.640838,
0.09419028,
-0.6249564,
0.6851596,
0.2079421,
0.1956796,
0.2522676,
0.2632237,
-0.05244821,
... |
[Determination of the KM-value of the fumarase (E.C. 4.2.1.2) with bencyclan-hydrogenfumarate as the substrate (author's transl)]. | The Michaelis-Menten constant for fumarase (E.C. 4.2.1.2) has been determined by measuring the enzyme activity by the spectrophotometric method of Racker, which depends on the formation or disappearance of the double bond of fumaric acid. When using Na2-fumarate or bencyclan hydrogenfumarate (Fludilat), respectively, a... | 20,899 | [
0.06015252,
-0.1364871,
0.1155897,
0.1262878,
0.04510392,
-0.08090305,
-0.1530616,
0.2372221,
-0.07083838,
-0.2100503,
0.1430369,
0.3809976,
0.3878161,
0.1367572,
-0.6370058,
-0.3286222,
-0.4264754,
0.246309,
0.06731076,
0.4572169,
0.2943627,
-0.03844739,
-0.2962424,
0.... |
A spectrofluorometric method for the determination of ajmaline in plasma. | 1 Ajmaline was found to have maximum fluorescence at neutral pH with 300 nm excitation and 365 nm emission wavelengths (corrected). 2 The fluorescence intensity had a linear relationship to concentration up to 50 microgram ml-1 and the recovery of ajmaline after extraction from plasma was 92.5 +/- 3%. 3 Extraction of d... | 20,915 | [
-0.3028971,
-0.2238625,
-0.5233365,
-0.3016746,
0.1710374,
0.09294757,
-0.05429823,
0.06615236,
-0.05547794,
-0.2701946,
0.1709856,
0.09027042,
0.1520457,
-0.3002878,
-0.4130055,
-0.2695783,
-0.4866734,
0.6279801,
-0.2799978,
0.2857696,
0.4313657,
0.2182892,
0.411024,
0... |
Site of bicarbonate effect in Hill reaction. Evidence from the use of artificial electron acceptors and donors. | Using artificial electron donors and acceptors, it is shown here that the major HCO3- effect in the Hill reaction is after the "primary" electron acceptor (Q) of Photosystem II and before the site of action of 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone (at the plastoquinone pool). Chloroplasts in the presence of b... | 20,948 | [
-0.2145772,
-0.2274856,
-0.1395319,
0.3579803,
0.02315047,
-0.1277121,
-0.1671446,
0.06295897,
-0.06244901,
-0.2608082,
0.2656391,
0.355175,
0.009508848,
-0.09380253,
-0.1065363,
0.1447033,
-0.5129644,
0.3950358,
-0.2603691,
0.1630893,
0.332118,
0.5106094,
0.09515674,
-... |
Resonance Raman study of the pH-dependent and detergent-induced structural alterations in the heme moiety of Rhodospirillum rubrum cytochrome c'. | The resonance Raman spectra and the structures of the heme moiety of Rhodospirillum rubrum cytochrome c' were investigated for its five states characterized by absorption spectra; Types-a and -n of the reduced form and Types-I, -II, and -III of the oxidized form. The frequency of the ligand-sensitive Raman line suggest... | 20,977 | [
-0.1773051,
-0.008086919,
-0.09230085,
0.02379504,
-0.1965534,
0.03921128,
0.05360536,
-0.3413374,
0.3257937,
0.3614108,
-0.3785987,
0.0540131,
0.1204958,
0.09815103,
-0.2919546,
-0.1836211,
-0.5481873,
0.1594503,
0.04887658,
0.01741959,
0.07975507,
0.09847157,
0.1015804,... |
[Functional role of parvalbumins in regulating Ca2+ in the contraction--relaxation cycle of vertebrate skeletal muscles]. | On the basis of parvalbumin property to change Ca2+-binding constant within the pH-region from approxim-tely 7 to approximately 8 a hypothesis that parvalbumins are pH-regulated Ca2+-depot in muscles has been stated. The addition of parvalbumin to native actomysin complex at pH approximately 7 in the presence of ATP an... | 20,987 | [
-0.3529616,
0.05783793,
-0.5274022,
0.4579567,
0.1073998,
-0.01827815,
-0.3391131,
0.1066963,
0.2804793,
-0.1808769,
-0.1051891,
0.1268628,
0.3864628,
-0.0382412,
-0.7445452,
-0.1157493,
-0.2603146,
-0.2762172,
-0.0805814,
0.03850908,
0.3573363,
0.1638167,
0.02898876,
0... |
[Effects of nucleophils on kinetic parameters of peroxidase-catalyzed oxidative reactions]. | The effect of imidazole on the kinetic parameters of reactions of potassium ferrocyanide and o-dianizidine peroxidation by hydrogen peroxide within a wide range of pH was studied. It was shown that imidazole activates the reaction of o-dianizidine peroxidation at pH greater than or equal to 6.5, but does not affect the... | 20,996 | [
-0.3241263,
-0.2161078,
0.09566473,
-0.1079857,
0.221431,
-0.1885101,
-0.1980552,
0.04938377,
0.1193408,
-0.1974622,
-0.1379851,
-0.08150154,
0.1048201,
0.02002463,
-0.8980334,
-0.03948484,
-0.5276576,
-0.02696721,
-0.002329831,
0.142291,
0.3075285,
-0.2222331,
-0.0809191... |
[Proteins of Bacillus thuringiensis delta-endotoxin crystals]. | Pure crystals (at least 99% purification) of sigma-endotoxin were isolated from Bac. thuringiensis var. galleriae. The complete dissolution of crystals might be achieved by the increase of pH up to 12 and higher or by a combined action of S = S-reducing and denaturing agents. Electrophoresis of the solubilized crystal ... | 21,000 | [
-0.1410298,
0.1382675,
0.1553254,
-0.1540799,
0.0008423356,
-0.2358913,
-0.3806469,
-0.03162566,
0.0299123,
-0.1344682,
-0.04584213,
-0.007490663,
-0.04556196,
0.04245534,
-0.6738643,
-0.03192936,
-0.2176128,
-0.03422704,
0.4426714,
0.227223,
0.2778714,
0.2198855,
-0.2103... |
Attitude change during behavioural treatment of sexual inadequacy. | Attitudes towards 'self' and 'partner' were studied in couples undergoing three different behavioural treatments for sexual inadequacy: systematic desensitization with counselling; guided practice with counselling; and practice with minimal counselling. Factor analysis of semantic differential scales identified five co... | 21,015 | [
-0.01653926,
0.5232427,
0.1208347,
-0.04091446,
0.3344177,
-0.3157284,
-0.03438035,
-0.3897519,
0.1553256,
-0.1887232,
0.06068554,
0.112331,
-0.1876974,
-0.09508366,
-0.3016889,
-0.02199279,
-0.7542829,
-0.04080498,
-0.1503428,
0.01627763,
0.1124911,
0.3542609,
-0.100603,... |
Clinical usefulness of alkaline phosphatase isoenzyme determinations. | 1. We report on the clinical usefulness of alkaline phosphatase isoenzyme determinations using a combined chemical inhibition method on 731 patient serum specimens exhibiting elevated (greater than 350 U/L) alkaline phosphatase (AP) activity. 2. The relative percentages of the organ-specific alkaline phosphatase activi... | 21,038 | [
-0.09633555,
-0.142914,
-0.3987592,
-0.1710256,
0.1361682,
0.03692883,
-0.2346978,
0.1249935,
0.07765976,
-0.2150134,
-0.04641578,
0.1155363,
0.06792582,
0.2646247,
-0.4794363,
-0.038521,
-0.2320292,
0.3369437,
-0.050886,
0.5429217,
0.06865584,
0.1288683,
-0.1634665,
0.... |
Prostatic binding protein. A steriod-binding protein secreted by rat prostate. | Rat prostatic cytosol contains a high concentration of a prostatic binding protein with peculiar steroid-binding properties. Indeed, in spite of a relatively low affinity, charcoal adsorption can be used for its measurement. Furthermore, the binding is not specific for particular steroids and increases very strongly af... | 21,076 | [
-0.1053583,
-0.057387,
-0.006509426,
-0.2384873,
-0.2115396,
-0.1738138,
-0.2943627,
0.1890589,
-0.1236948,
0.1050365,
0.2737577,
0.06626278,
0.02321912,
0.06275817,
-0.4060794,
0.06502352,
-0.5089123,
-0.1593484,
0.2284548,
0.08547975,
0.3593321,
0.149423,
-0.03655041,
... |
A new factor from enteric bacteria of rats amplifying induction of liver enzyme by glucocorticoid. 2. Mechanism of action. | 1. An amplifier of the action of glucocorticoid was purified from Proteus mirabilis as described previously. It was found that it amplified the induction of liver tyrosine aminotransferase by dexamethasone markedly with doses of dexamethasone that caused minimal enzyme induction, but had little effect with doses that c... | 21,084 | [
0.07669067,
-0.04886789,
0.04533062,
0.02847735,
-0.1433489,
-0.267304,
-0.2620349,
0.06028296,
-0.03391936,
-0.1878805,
-0.1235824,
-0.2635323,
0.2486821,
0.2281908,
-0.559289,
0.09188157,
-0.249982,
-0.4281378,
0.1991081,
0.2816875,
0.3608988,
-0.004800878,
-0.08320237,... |
Ionization behaviour of native apolipoproteins and of their complexes with lecithin. 1. Calorimetric and potentiometric titration of the native apoA-I protein and of the apoA-I protein-dimyristoyl lecithin complex. | The ionization behaviour of native apoA-I protein is compare to that of its complex with synthetic dimyristoyl lecithin in studies using calorimetric, potentiometric and spectrophotometric titration. In the presence of phospholipids, 10 out of 21 lysines together with 22 acidic residues are masked in the complex. All t... | 21,089 | [
0.108085,
0.2294038,
-0.4125639,
0.2469731,
0.04355185,
-0.08700027,
-0.0535646,
0.1950339,
0.1131348,
-0.03280336,
0.07612947,
0.2130776,
-0.06085296,
-0.2227191,
-0.3456242,
0.1641683,
-0.5611054,
0.2335266,
-0.2170401,
0.1316853,
0.1184075,
-0.004513371,
0.04651473,
... |
The structure and function of ribonuclease T1 XXIV. Preparation and properties of a stable water-insoluble polyacrylamide derivative of ribonuclease T1. | Ribonuclease T1 [EC 3.1.4.8] was coupled to a water-insoluble cross-linked polyacrylamide (Enzacryl AH) by the acid azide method. The immobilized enzyme exhibited about 45% and 77% of the original activity toward yeast RNA and 2', 3-cyclic GMP, respectively, as substrates. Although the specific activity was lowered by ... | 21,179 | [
-0.04176703,
-0.1588633,
0.004941402,
-0.009727757,
0.1831637,
-0.1740734,
-0.09686197,
0.1158505,
0.2207987,
-0.05573036,
0.1295672,
0.3782073,
0.2145788,
-0.08636766,
-0.3186962,
0.1420528,
-0.5981748,
-0.1407806,
-0.3598126,
0.09096816,
0.5144757,
-0.02533243,
-0.37109... |
Studies of the beta-galactoside transporter in inverted membrane vesicles of Escherichia coli. I. Symmetrical facilitated diffusion and proton gradient-coupled transport. | Facilitated diffusion of [14C]lactose into inverted membrane vesicles of Escherichia coli was measured using HgCl2 as a stopping reagent and polylysine to flocculate the vesicles for filtration. Equilibration of lactose between the internal and external volumes required expression of the y gene of the lac operon and wa... | 21,183 | [
-0.447247,
0.03721163,
-0.1171325,
0.2397785,
0.005785581,
-0.2979184,
-0.03716878,
-0.1443601,
-0.09456696,
-0.008568252,
0.09703406,
0.2401799,
0.2485706,
0.1946194,
-0.3311218,
0.08027133,
-0.2900772,
-0.2946146,
-0.157061,
-0.3881438,
0.396795,
-0.01490134,
-0.0799853... |
Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora. IV. The COOH-terminal 669 residues of the peptide chain; comparison with other glutamate dehydrogenases. | A sequence is presented for the COOH-terminal 669 residues of the NAD-specific glutamate dehydrogenase of Neurospora crassa. Comparison of this sequence with those of the vertebrate glutamate dehydrogenases of chicken and bovine liver and with the NADP-specific enzyme of Neurospora shows some similarities in sequences ... | 21,191 | [
-0.08141048,
-0.1052004,
-0.09378313,
0.03009298,
0.07947876,
-0.1590751,
-0.03088568,
-0.04064718,
-0.1444532,
0.03971273,
0.3261891,
0.04643953,
0.2692765,
0.1425129,
-0.5079948,
0.04785888,
-0.5822788,
0.2431301,
-0.1028164,
0.1457742,
0.3026094,
0.3851151,
0.1280901,
... |
Adsorption of horseradish peroxidase, ovomucoid and anti-immunoglobulin to colloidal gold for the indirect detection of concanavalin A, wheat germ agglutinin and goat anti-human immunoglobulin G on cell surfaces at the electron microscopic level: a new method, theory and application. | A method is described for the adsorption of selected macromolecules to colloidal gold which is then used as an electron dense marker for the indirect detection of specific cell surface molecules. Membrane bound concanavalin A, which binds specific sugars on horseradish peroxidase, and wheat germ agglutinin, which binds... | 21,217 | [
0.1823383,
-0.05911509,
-0.09221412,
0.008694609,
0.2347485,
-0.1931908,
-0.2079103,
0.2043259,
-0.03881041,
0.1810176,
0.09520915,
0.1028299,
-0.1522759,
-0.006865631,
-0.09682143,
0.1373874,
-0.55495,
-0.04194804,
0.2092665,
-0.30608,
0.458699,
0.08598853,
-0.2109161,
... |
A comparison of the dissolution rates of caffeine tablets in a rotating-basket with those in a Sartorius dissolution tester. | Uncoated caffeine tablets of four different hardnesses were tested for dissolution rate by the Sartorius (S.S. method) and by the rotating basket method of the U.S.P. XVIII. In both methods the dissolution rate decreased with increasing hardness, and the rate obtained with the S.S. method was always less than that by t... | 21,235 | [
-0.07732206,
-0.04903102,
-0.02479932,
0.05629187,
0.2728123,
-0.3118815,
-0.1302485,
0.1087321,
0.2419832,
-0.04721302,
0.1235748,
0.3486359,
-0.07445987,
0.2950644,
-0.5678342,
-0.2100641,
-0.2968239,
0.06952101,
-0.5228977,
-0.07568757,
0.1783715,
-0.09023674,
-0.33485... |
Biochemical and pharmacological studies on amineptine (S 1694) and (+)-amphetamine in the rat. | The pharmacological activities of amineptine (S 1694) and (+)-amphetamine and their interaction with biogenic amines have been examined in rats. The locomotor activity, stereotyped behaviour and hypothermia induced by amineptine were similar to but not as marked as those produced by (+)-amphetamine, and there was littl... | 21,261 | [
-0.1853701,
0.1102025,
-0.2607822,
-0.3279344,
-0.08900885,
-0.2862889,
-0.4290345,
-0.2060273,
0.1686917,
0.05524293,
-0.05195564,
0.1813956,
-0.102412,
0.1873581,
-0.4437801,
0.1828956,
-0.3152721,
0.1512718,
-0.1193268,
0.4381494,
0.0124444,
0.173674,
-0.003488176,
-... |
Monoamine oxidase and catechol-O-methyl transferase activity in Tetrahymena. | Tetrahymena pyriformis strain HSM was found to have monomine oxidase (MAO) and a catechol-3-methyl transferase-like (COMT) activity. As in mammalian tissues, the MAO activity is predominantly localized in the mitochondrial pellet and COMT in the cytosol. The COMT-like activity was present in amounts comparable to sever... | 21,289 | [
-0.2940299,
-0.2274961,
-0.1956843,
-0.1492937,
-0.3708975,
0.04131205,
-0.05198207,
0.1682667,
-0.01418389,
-0.286229,
0.1158988,
0.2075872,
0.1005925,
0.2936209,
-0.6941277,
0.02406843,
-0.6159508,
0.2340022,
-0.1198455,
0.5321777,
0.08325154,
0.3113573,
-0.05314538,
... |
Synthesis and pharmacological activity of some N-alkyl-substituted 9alpha-ethyl-2'-hydroxy-5-methyl-6,7-benzomorphans. | A series of N-substituted 9alpha-ethyl-2'-hydroxy-5-methyl-6,7-benzomorphans was synthesized and evaluated for their narcotic analgesic and antagonistic activities. Compounds 2a and 22 were as potent as morphine in the writhing (PPQ) and hot-plate tests, while a number of compounds demonstrated antagonistic activities ... | 21,291 | [
-0.03409865,
0.1514251,
-0.2630542,
-0.03348034,
-0.1470779,
-0.004289746,
-0.3588103,
0.0113508,
-0.003394726,
-0.4386891,
0.2090795,
-0.1360158,
0.1542018,
0.138446,
-0.5537921,
-0.1313429,
-0.494657,
0.2420814,
0.1594307,
0.3450071,
0.06776889,
-0.004101543,
-0.1333534... |
Bilateral seminoma 34 years after orchiopexy. | A case of bilateral seminoma in a 59-year-old patient who had undergone bilateral orchiopexy 34 years previously is presented. To our knowledge this is the longest interval between an orchiopexy and diagnosis of bilateral malignancy. | 21,310 | [
-0.189597,
-0.07504579,
-0.2827975,
-0.4488038,
0.05148801,
-0.2292825,
-0.2194131,
-0.3031696,
-0.05745284,
-0.06622211,
0.3866053,
0.4760037,
-0.009260059,
-0.08596686,
-0.2028722,
-0.09751014,
-0.2683742,
0.07780798,
-0.182633,
-0.07260301,
0.3021924,
0.1279532,
-0.065... |
[Evaluation of antireflux effect of fundic patch operation by withdrawal pH curve (author's transl)]. | With the use of gastroesophageal withdrawal pH curve, pathophysiology after various surgical procedures for achalasia of the esophagus was investigated experimentally from the view point of postoperative reflux. A total of 68 dogs were divided into four groups and were prepared with proximal gastrectomy with end-to-end... | 21,321 | [
0.2232923,
-0.2362402,
-0.4253668,
-0.2371918,
0.1339697,
-0.02009085,
-0.1187139,
-0.07999342,
0.07888845,
0.1572847,
0.09714627,
-0.07245804,
0.253076,
-0.3849507,
0.1654188,
0.3543018,
-0.4387048,
0.3593216,
-0.04115206,
0.2622784,
0.01777547,
0.2013241,
0.04923966,
... |
Arginine esterase and lysosomal hydrolases in liver from cystic fibrosis subjects. | The total activity and isoelectric focusing patterns of arginine esterase, cathepsin B1, and several lysosomal hydrolases were normal in liver from two patients with cystic fibrosis. No abnormalities were observed in values for pH optimum, Km, and Vmax for arginine esterase and cathepsin B1 in liver from cystic fibrosi... | 21,378 | [
-0.08738763,
0.05697925,
-0.1678428,
-0.04014565,
0.1069512,
-0.1518908,
0.0980081,
-0.3888218,
-0.1440883,
0.2273087,
-0.01574199,
0.2880082,
-0.06872115,
0.2323659,
-0.2608215,
0.1326581,
-0.4895111,
0.147402,
0.1171123,
-0.1235182,
-0.2351545,
0.3468204,
0.004856208,
... |
[Septicemia in the elderly (author's transl)]. | Out of 1,251 patients above 65 years of age staying at the Charles Foix Hospital (prolonged hospitalization) and the St. Joseph Hospital (acute cases), 168 had one or more positive blood cultures. Urinary tract infection is a major source of septicemia due to gram negative bacilli. It is important to stress cases of se... | 21,383 | [
0.1045217,
-0.3821202,
0.09072967,
-0.1624062,
0.1707792,
-0.2963382,
-0.4479181,
-0.01582406,
-0.1292988,
-0.1204266,
-0.1508668,
-0.2052804,
0.06429732,
0.01711928,
-0.2943562,
-0.2654587,
0.1039109,
-0.1121481,
0.1740156,
0.07057637,
0.1384212,
-0.03825049,
-0.1801827,... |
Gastro-oesophageal acid reflux in patients with symptomatic hiatus hernia and effect of a modified Belsey MK IV repair on acid reflux. | Twelve-hour continuous recording of pH at the distal end of the oesophagus was carried out in 59 patients with sliding hiatus hernia and symptoms suggestive of gastro-oesophageal reflux, and the results were compared with those obtained in normal subjects. Mean duration of pH less than or equal to 2.3, pH less than or ... | 21,444 | [
0.2626971,
0.08287463,
-0.2436189,
-0.1247885,
0.2769271,
-0.1394277,
0.08404473,
0.1583892,
0.2943723,
-0.0007353454,
0.2712712,
-0.05629769,
0.02355181,
-0.3974587,
-0.5542059,
-0.262846,
-0.2095107,
0.2701309,
0.09208008,
-0.02279462,
0.5196825,
-0.06065844,
0.07498036... |
Deuterolysis of amino acid precursors: evidence for hydrogen cyanide polymers as protein ancestors. | Deuterolysis experiments suggest that hydrogen cyanide polymers rather than aminoacetonitriles are major precursors of alpha-amino acids obtained from spark reactions and other studies on chemical evolution. These results are consistent with the hypothesis that the original heteropolypeptides on the earth were synthesi... | 21,452 | [
-0.3609409,
-0.144506,
-0.2585468,
0.3751566,
0.11038,
-0.1956928,
-0.3763157,
0.1074236,
0.3201798,
0.004431293,
0.005608115,
0.2205554,
0.2424063,
-0.2181171,
-0.2457421,
-0.3536945,
-0.1919309,
0.1161747,
0.1681529,
-0.3137704,
0.3114075,
0.006255557,
-0.1874008,
-0.... |
Splenic-gonadal fusion and adrenal cortical rest associated with bilateral cryptorchism. | A patient with bilateral cryptorchism had ectopic splenic tissue adherent to his left testicle and an adrenal cortical rest adherent to his right testicle. The embrylogic basis for these disorders is discussed and the literature reviewed. | 21,481 | [
-0.07867366,
-0.05639592,
-0.1088054,
-0.2116781,
-0.1501197,
-0.08351126,
-0.3988113,
-0.1352504,
-0.05709793,
0.1975718,
0.3274505,
0.2359134,
-0.2296928,
-0.03091566,
-0.6400296,
0.08460799,
-0.385601,
-0.2002908,
-0.1235803,
-0.3480612,
0.3233579,
-0.1304174,
-0.20863... |
[Role of autoimmune processes in the pathogenesis of post-vaccinal lesions of the nervous system]. | Subcutaneous sensitization of guinea pigs with -vaccine, and also an intracardiac injection of smallpox or measles vaccine induced production of brain autoantibodies, whereas subcutaneous or intradermal immunization of the animals with liver viral vaccines was not accompanied by the formation of autoantibodies and deve... | 21,500 | [
-0.2632089,
-0.4801841,
-0.01252574,
-0.2640341,
-0.2085623,
-0.4095438,
-0.3532324,
0.05623846,
-0.0761597,
0.2070135,
0.1305915,
-0.110326,
0.3786628,
-0.2416352,
-0.4276603,
0.007324575,
-0.5845291,
-0.2748724,
0.0776357,
0.2491479,
0.1200454,
0.221149,
-0.07850999,
... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.