title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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An extrarenal source of "renin-like" activity in anephric man. | To examine extrarenal sources of "renin-like" activity plasma was obtained from 19 anephric males. Plasma renin activity (PRA), concentration (PRC) (obtained after addition of exogenous renin substrate) and total renin concentration (TRC) (obtained after acid-activation of plasma and subsequent incubation with exogenou... | 15,733 | [
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An inactive renin in human plasma. | Normal human plasma contains an active form of renin that is activated by acidification to pH 3.0 and comprises 56% of the total renin. In our study, inactive renin was also present in plasma from five anephric persons, and the proportion of active to inactive renin in these subjects was similar to normal. Plasma from ... | 15,736 | [
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Lung pH and pulmonary absorption of nonvolatile drugs in the rat. | The effect of pH on pulmonary absorption of nonvolatile drugs was investigated in the rat. Krebs-Ringer phosphate solutions (pH 6.2 and 7.4), Krebs-Ringer pyrophosphate solution (pH 8.4), or an unbuffered salt solution containing a drug were administered through tight-fitting tracheal cannulas to anesthetized animals. ... | 15,810 | [
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Metabolism of haloforms to carbon monoxide. I. In vitro studies. | Trihalomethanes (haloforms) were metabolized to carbon monoxide by a rat liver microsomal fraction requiring both NADPH and molecular oxygen for maximal activity. GSH alone did not serve as a cofactor; however, GSH in the presence of NADPH and oxygen produced an 8-fold increase in the metabolism of bromoform to CO. Sim... | 15,814 | [
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Neuropsychological deficit in polydrug users. A preliminary report of the findings of the collaborative neuropsychological study of polydrug users. | The Collaborative Neuropsychological Study of Polydrug Users performed extensive neuropsychological assessments on 15 polydrug users 3 weeks after their enrollment in each of eight polydrug demonstration programs. Fifty-six (37%) of these subjects exhibited neuropsychological deficit. This deficit was partially related... | 15,818 | [
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Disposition of carbamazepine and its 10,11-epoxide metabolite in the isolated perfused rat liver. | The disposition of carbamazepine and its metabolite, the 10,11-epoxide, was investigated in isolated perfused livers from control and phenobarbital-pretreated rats. The mean hepatic clearance of carbamazepine was 0.28 ml per min per g of liver corresponding to a mean extraction ratio of 0.16 and a mean intrinsic cleara... | 15,811 | [
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Purification of bovine thyroid peroxidase. | Trypsin-solubilized peroxidase activity from beef subcellular particles was resolved by DEAE-cellulose chromatography into 5 fractions, which contained enzymatically active components that ranged in molecular size from 73,000 to 340,000 daltons. The most active fraction (mol wt, 92,000 by gel filtration) was further pu... | 15,822 | [
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The interaction of phospholipid membranes and detergents with glutamate dehydrogenase. | 1. Both the anionic detergent sodium dodecylsulphate and the cationic detergent cetyltrimethylammonium bromide quenched the protein fluorescence of glutamate dehydrogenase. The anionic compound was more effective and brought about 50% quenching at a detergent concentration of 0.4 mM. The zwitterionic amphiphile, lysole... | 15,832 | [
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The purification and properties of NADP-dependent isocitrate dehydrogenase from ox-heart mitochondria. | The purification of NADP-linked isocitrate dehydrogenase from ox heart mitochondria is described. The molecular weight from gel filtration, sedimentation equilibrium and gel electrophoresis is 90000+/-4000, and there are two subunits in the molecule each of which binds NADPH with enhancement of the coenzyme fluorescenc... | 15,840 | [
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[Effect of narcotics on impulse conduction in the afferent pathways of visceral nerves]. | In tests set up on cats immobilized with pyraxolone and anatruxonium the effect of non-inhalation narcotics on the evoked potentials of the cortex and subcortical structures with visceral and also somatic, acoustic and photo-stimulation was studied. With stimuli of different modality sodium ethaminal was found to inhib... | 15,858 | [
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Laparoscopic sterilization in the puerperium: a review of international experience. | The feasibility of using laparoscopic techinques for pueperal sterilization has been demonstrated on three continents. While the operation is not suggested to replace all other methods of pueperal sterilization, it is advantageous in selected situations. | 15,906 | [
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Prophylactic antibiotic in elective gynaecological and obstetrical major surgery. | A prospective controlled study of 580 patients who underwent non-radical major gynaecological or obstetrical surgery examined the use of prophylactic antibiotics. The test group of patients (290) showed a significantly lower (P=0.01) incidence of the total complications and the non-infective complication rate as agains... | 15,908 | [
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[Mycoses. Pathogenicity and diagnosis of dermatophytes, yeasts and molds]. | Human beings today living in high industrialized areas suffer more frequently from fungal diseases than before. This is due to the management in animal production, but also to the use of cosmetics and contraceptives, smoking cigarettes, wearing clothes of synthetic polymers and application of new drugs, like antibiotic... | 15,935 | [
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The differential diagnosis of crescentic glomerulonephritis. The pathology of specific lesions with prognostic implications. | Combined findings from light and electron microscopy with immunofluorescence studies make a definitive diagnosis possible in most cases of crescentic glomerulonephritis. The patient's prognosis and pattern of response to therapy are matters of immediate concern in the light of recent developments in nephrology. The fre... | 15,939 | [
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Early events in the induction of glutamine synthetase activity by hydrocortisone in embryonic chick neural retina. | Primary cultures of 10-day embryonic chick neural retinas were used to investigate early aspects of the mechanism of hydrocortisone action on glutamine synthetase activity. As little as 2 hr of hydrocortisone exposure served to initiate significant increases in the glutamine synthetase activity levels assayed after 24 ... | 15,942 | [
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The activation of intravascular coagulation by bromocarbamide. | In the rabbit the application of a non-lethal, sleep-inducing dose of bromisovalerianyl carbamide (0.5 g/kg body weight) causes an activation of the coagulation system. This activation is manifested by shortened thrombin and partial thromboplastin times and a decrease of fibrinogen concentration and Factor V activity. ... | 15,952 | [
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Alkaline phosphatase of Blastocladiella emersonii: partial purification and characterization. | Alkaline phosphomonoesterase (EC 3.1.3.1) activity from Blastocladiella emersonii, while displaying typically broad substrate specificity for phosphorylated organic compounds, exhibited nearly complete substrate preference for N-acetylglucosamine-6-phosphate over N-acetylglucosamine-1-phosphate. Enzyme in zoospore extr... | 15,978 | [
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Localization of enzymes in Ureaplasma urealyticum (T-strain mycoplasma). | Ureaplasma urealyticum cells were lysed by osmotic shock or by digitonin. The membrane fraction contained four to ten times as much protein as the cytoplasmic fraction. These values are in large excess of those reported for classical mycoplasmas, suggesting that the Ureaplasma membrane fraction was heavily contaminated... | 15,980 | [
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Regulation of galactose oxidase synthesis and secretion in Dactylium dendroides: effects of pH and culture density. | The effects of pH and growth density on the amount of an extracellular enzyme, galactose oxidase, synthesized by the fungus Dactylium dendroides were studied. Growth at a pH below 6.7 caused a decrease in the ability of the organism to release galactose oxidase. The enzyme retained by these fungal cells was liberated w... | 15,985 | [
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O-alkylhomoserine synthesis catalyzed by O-acetylhomoserine sulfhydrylase in microorganisms. | An enzyme that can synthesize O-alkylhomoserine from alcohols and O-acetylhomoserine was purified from Corynebacterium acetophilum. The enzyme was found to be identical to O-acetylhomoserine sulfhydrylase; a preparation that appeared homogeneous on polyacrylamide gel electrophoresis showed both O-alkylhomoserine-synthe... | 15,989 | [
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Enzymatic conversion of bilirubin monoglucuronide to diglucuronide by rat liver plasma membranes. | Formation of bilirubin monoglucuronide from unconjugated bilirubin requires a microsomal enzyme, UDP-glucuronate glucuronyltransferase (EC 2.4.1.17). Conversion of bilirubin monoglucuronide to bilirubin diglucuronide, the major bilirubin conjugate in bile, was studied in subcellular fractions of rat liver. The highest ... | 15,996 | [
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Characterization of the m7G(5')pppN-pyrophosphatase activity from HeLa cells. | The m7(G(5')pppN-pyrophosphatase activity previously detected in HeLa cells has been further characterized. Results from DEAE-cellulose column chromatography and polyacrylamide gel electrophoresis under nondenaturing conditions revealed only one enzyme activity in HeLa cell extracts which was capable of selectively hyd... | 16,003 | [
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Epidermal nucleases. II. The multiplicity of ribonucleases in guinea-pig epidermis. | Ribonuclease activity has been extracted from adult guinea-pig epidermis by sequential homogenization in dilute sodium acetate and sulfuric acid. The extracts were subjected to ammonium sulfate fractionation and to affinity and ion exchange chromatography. Three ribonucleases (I, II, III) were separated from the sodium... | 16,063 | [
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Motor innervation of the smooth muscle of the rat seminal vesicle. | Frequency-related isovolumetric contractions of the rat seminal vesicle elicited with transmural electrical stimulation were blocked by tetrodotoxin but unaffected by hexamethonium. The postganglionic motor innervation of the rat seminal vesicle is purely excitatory and contains both an adrenergic and a cholinergic com... | 16,117 | [
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Urinary carbon dioxide tension in lithium carbonate-treated patients. | Renal acidification was studied in 12 lithium carbonate-treated psychiatric patients. The urinary Pco2 response to oral sodium bicarbonate loading, a qualitative index of distal hydrogen ion secretion, was evaluated in all patients and the results were compared with those obtained in 10 control subjects. The average ma... | 16,123 | [
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Possible explanations for the differences in secretory characteristics between conjugated and free bile acids. | 1. The hepatic extraction fraction and maximum excretory rate of conjugated cholate are greater than those of free cholate (studied after acute taurine depletion); the possibility that this difference might be due to greater bile-to-blood back-diffusion of un-ionized cholic acid (pKa 5-5) compared to that of taurocholi... | 16,125 | [
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The effect of calcium injection on the intracellular sodium and pH of snail neurones. | 1. Ion-sensitive glass micro-electrodes were used to measure the intracellular pH (pHi) and the intracellular sodium ion concentration, [Na+]i, in identified Helix aspersa neurones. 2. The injection of small volumes of 0-1 McaCl2, which increased the membrane potential by 10-15 mV for 1-2 min, had little or no effect o... | 16,126 | [
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Growth of a heterologous tumor cell line in neonatal rats with graft-versus-host disease. | The ability of a hamster tumor cell line (T20) to grow and exhibit type H virus particles was significantly enhanced in neonatal DA rats with graft-versus-host disease (GVHD). Tumor growth peaked on days 4 and 7 in control littermates receiving adult syngeneic cells or no cells at birth, respectively, and then subseque... | 16,141 | [
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0.06161947,
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0.05579411,
0.05421568,
0.03214239,
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-0.1094995,
0.3597548,
0.006039495,
0.4306728,
0.2088375,
-0.071797... |
[Oto-palato-digital (Taybi) syndrome]. | A case of dysmorphogenetic syndrome, described by Taybi, is reported. The syndrome is characterized by hardness of hearing of conduction type, submucous cleft palate and anomalies involving the bony frame, especially the digits. | 16,178 | [
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... |
Cataract and gamma-glutamyl cycle in myotonic dystrophy. | Gamma-Glutamyl transpeptidase (gamma-GT) may be responsible for the rapid catabolism and low levels of lenticular glutathione often associated with cataract formation. Elevated levels of serum gamma-GT in patients with myotonic dystrophy suggest that since the defect could be present in all tissues it might be responsi... | 16,240 | [
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Pigment epithelial ensheathment and phagocytosis of extrafoveal cones in human retina. | The association between extrafoveal cone outer segments and pigment epithelial cells was studied by transmission electron microscopy in three human retinas; ages 5,45 and 60. The pigment epithelial apical surface from a fourth human retina, age 38,was viewed in the scanning electron microscope. Multiple villous-like ap... | 16,301 | [
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0.3932891,
0.1590772,... |
Alpha-adrenergic blockers on ventricular automatism in rat heart. | The role of the alpha-adrenergic receptors in the genesis of cardiac arrhythmias induced in the isolated rat right ventricle has been studied. The administration of six alpha-adrenergic blocking agents (phenoxybenzamine, dibenamine, phentolamine, tolazoline, azapetine and SY-28) did not alter the automatism induced. Ev... | 16,319 | [
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... |
[Isolation of the islands of Langerhans from rat pancreas and determination of proteolytic activity in them]. | A modified method for isolation of Langerhans islands from rat pancreas is described. The islands obtained were free from acinous tissue as shown by means of an amylase test and by microscopy. In homogenates of the islands proteolytic activities were observed (pH optimum at 5.3--5.5 and 6.9--7.2). | 16,389 | [
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0.1772677,
... |
Distribution of coronary blood flow in the left ventricular wall of dogs evaluated by the uptake of Xe-133. | The distribution of coronary blood flow was estimated in anesthetized dogs by counting the activity in tissue blocks of the left ventricular free wall immediately after bolus injection of Xe-133 into the aortic root. No differences in the uptake of isotope were observed between the apex and the base of the heart; betwe... | 16,436 | [
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0.141786... |
Uric acid transport characteristics in human erythrocytes. | Taken all together the results show that the RBC transport of U.A. seems to be partly of passive nature, closely similar to others mineral or organic anions, and partly of active nature related to compound of the membrane playing a role in cellular metabolism. It remains to be precised the role of the membrane itself a... | 16,456 | [
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0.547231,
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Observations on the feeding and defecation patterns of three triatomine species (Hemiptera: Reduviidae). | A comparative laboratory study of feeding and defecation behavior of three species of tritomines (Rhodnius prolixus, Triatoma infestans and T. dimidiata) indicated evident differences among the species and among the different stages of same species. Time required for a full blood meal was related to the size of the spe... | 16,468 | [
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0.1725259,
0.15... |
Effect of gallstone-dissolution therapy on human liver structure. | To assess potential toxic effects liver biopsies were performed before and after 6-8 months therapy with chenodeoxycholic acid (CDCA), 750 mg daily, in 6 patients with gallbladder stones. Minor fatty change and lipofuscin were seen prior to therapy, which tended to increase afterwards. Otherwise there was no consistent... | 16,480 | [
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... |
Computer simulation of rat heart metabolism after adding glucose to the perfusate. | An experiment where perfused rat hearts receiving no substrate are suddenly given glucose with insulin in the perfusate is simulated with a computer model of cardiac energy metabolism. Mitochondrial metabolism is quantitatively reorganized under cytoplasmic control, with fatty acid oxidation undergoing a two-step decre... | 16,503 | [
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0.3109691,
0.006593842,... |
Relationship between gastric mucosal pH and site of peptic ulceration. | Measurements of mucosal pH of resected stomachs were carried out in gastric and duodenal ulcer patients. Low mucosal pH along the lesser curvature and relatively higher gastric pepsin levels were found. It is suggested that this lower pH affects gastric ulcer occurrence in the limited "lesser curvature area" where 63 p... | 16,504 | [
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0.0250032,
0.0392535... |
[Membrane oxygenators in cardiac surgery: progress]. | This study tries to define if the membrane oxygenators are available during cardiac surgery under E.C.C., and if their performance are superior to those of conventional oxygenators. Two series of research are done. In the first one, we compare performance of two membrane oxygenators: the Rhône-Poulenc heart-lung machin... | 16,518 | [
-0.1739662,
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0.4015957,
0.3039116,
0.2225801,
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0.... |
[Methods of sampling and preservation of blood used during extracorporeal circulation]. | The blood supply of Cardiac Surgery Centers set quantitative and qualitative problems to the Centers of blood dispatch. In this work, from a Lyonese experience on 4,000 E.C.C., authors try to define the best preservative solution, especially for the respiratory function of the red blood cell. The C.P.D. solution (citra... | 16,519 | [
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0.01620261,
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0.5652691,
0.3843312,
-0.08921456,
-0.01591743... |
[Protection of the myocardium by hypothermia during extracorporeal circulation. Experimental and clinical study]. | Hypothermic protection of myocardia during E.C.C. has been estimated on a 35 dogs experimental series and on a clinical series of 700 acquired cardiopathies of adult, including 400 valvular replacements and 300 aorto-coronary by-pass. Experimental results have been estimated by biochemic and morphologic controls done o... | 16,526 | [
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0.072165,
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0.4642533,
0.3726858,
0.2760895,
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0.15... |
[Myocardial protection by coronary perfusion and specific problems of myocardial protection in combined valvular and coronary surgery]. | The quality of the myocardial protection by bilateral coronary perfusion was studied in a consecutive series of 80 patients treated by isolated aortic replacements (47 cases) or multiple replacements (mitro-aortic, or mitro-aortic and tricuspid) 33 cases. Four low outputs (5 p. 100) were observed with only one death. F... | 16,527 | [
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0.3150358,
0.362537,
0.1044472,
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... |
[Drug protection of the myocardium during cardiac surgery]. | During aortic clamping, drug protection of the myocardium, far from supplanting hypothermia, complements it, particularly in the case of left ventricular hypertrophy. Ultramicroscopy and new techniques of histobiological exploration of the myocite have enabled one to distinguish the lessions provoked by anoxia from tho... | 16,531 | [
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0.5221073,
0.2323832,
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[Shivering during recovery after cardiac surgery under extracorporeal circulation. Inconveniences and methods of prevention]. | Among 109 subjects who had undergone cardiac surgery under ECC, the authors recorded 50 (45 p. 100) who suffered from shivering during the coming round period. Comparing the series of patients who shivered, with that of the subjects who did not shiver, the authors demonstrate in the first case, an increase in cellular ... | 16,532 | [
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0.5457011,
0.09531897,
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0.... |
[Use of a membrane oxygenator in extracorporeal circulation in the child. Preliminary conclusions]. | The comparison of two types of oxygenators, the bubble and membrane oxygenator, in cardiac surgery under ECC, in infants. The results were not subjected to a statistical study. However, it seems that the membrane oxygenator enables one to obtain a satisfactory hematosis in a simpler fashion (the addition of CO2 being a... | 16,540 | [
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0.5384783,
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... |
Renal function during and following obstruction. | The effects of urinary-tract obstruction on renal function have been clarified using modern physiologic techniques in animal models. These effects are obviously dependent on the severity and duration of obstruction, together with the presence or absence of extrarenal factors, particularly uremia, as exemplified by the ... | 16,559 | [
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0.2389128,
-0.09380043... |
Neurophysiologic and pathologic aspects of acute and chronic pain. | Acute pain produced by disease or injury is the net effect of highly complex interactions of various neural systems and psychological factors. Through the interaction of the afferent systems and neocortical processes, the individual is provided perceptual information regarding location, magnitude, and spatial and tempo... | 16,580 | [
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0.158958,
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The intracellular pH and the buffer capacity of the heart. | The intracellular buffering (delta HCO3-/delta pH) in rats is lowest in skeletal muscle, intermediate in the diaphragm and highest in cardiac muscle. In the hypertrophic heart due to aortic constriction or to the Goldblatt mechanism the buffer value increases markedly during the first weeks, but returns to normal or ev... | 16,587 | [
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Serum gonadotropins in the rat after prenatal damage to the testes by busulfan and their reaction to cryptorchidism, castration and administration of testosterone. | Adult male rats prenatally treated with 1,4-bis-(methanesulfonyloxy)-butane (busulfan), which damages the gonocytes, undergo cryptorchidization, castration or testosterone treatment and the FSH, LH and testosterone levels in serum are measured. Basal values of these hormones do not differ from those of controls. After ... | 16,621 | [
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0.01574128,
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... |
Possible regulation of thiamine diphosphatase activity in rat brain microsomes by lipids. | The effects of various treatments, which affect membrane structure, on microsomal thiamine diphosphatase and thiamine triphosphatase activities of rat brain, were examined. The treatment of micorosomes at alkaline pH caused a 2-fold activation of the thiamine diphosphatase, this being related to a change in membrane st... | 16,655 | [
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The interaction of histone H3 with histone H4 and with other histones studied by 19F nuclear magnetic resonance. | The behaviour, upon variations in ionic strength, pH and temperature of 19F nuclear nuclear magnetic resonance signals of the trifluoroacetonylated derivative of histone H3 is compared with those of the H3-H4 complex and of the Hv fraction (an equimolar mixture of H2A, H2B, H3 and h4). The line width of the 19F-labelle... | 16,662 | [
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The denaturation of beta-lactoglobulin-A at pH 2. | The denaturation of beta-lactoglobulin-A by heat and guanidine hydrochloride at pH 2 has been investigated. The effect of ethylene glycol on the thermal denaturation at this pH has also been studied. The conditions of the experiments have been chosen so as to eliminate complications arising out of disulfide interchange... | 16,664 | [
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... |
[Influence of pH on the steady state kinetics of electron transfer through the cytochrome chain of submitochondrial particles. Kinetic model for regulating the activity of carriers by the local concentration of hydrogen ions in the membrane]. | The kinetic parameters of the submitochondrial particles cytochrome chain obtained from steady-state kinetics were studied for pH dependence. The life-times of the activated states (tau) for cytochrome pairs b leads to c1 and a leads to a3 are shown to bear dissimilar dependence on pH of the medium, while for cytochrom... | 16,667 | [
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... |
Human cytomegalovirus. A review of developments between 1970 and 1976. I. Clinical developments. | Cytomegalovirus (CMV), like other members of the herpesviruses, is widely distributed in human populations where the frequency of seropositive individuals is influenced by such factors as age, sex and socio-economic conditions. While this virus causes such diseases as mononucleosis, it is also implicated in autoimmune ... | 16,671 | [
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0.2844708,
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[Blood gas measurements and automatization (author's transl)]. | The Corning 175, a fully automatic new blood-gas analyzer, was tested and compared with manual analyzers (Eschweiler-Radiometer). The precision was evaluated by means of tonometered bloods and precision gas mixtures. With the Corning 175 four parameters are measured: pH, PCO2, PO2, barometric pressure, and four compute... | 16,678 | [
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... |
Striatal lesions with kainic acid: neurochemical characteristics. | Stereotaxic injection of 2.5 microng of kainic acid, a rigid analogue of glutamate into the rat striatum caused a 70% reduction in the striatum of the cholinergic parameters, choline acetyltransferase, acetylcholine and synaptosomal uptake of choline and a similar reduction in the GABAergic parameters, glutamic acid de... | 16,686 | [
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Cardiovascular effects of total hip placement in man. With observations on the effects of methylmethacrylate on the isolated rabbit heart. | The cardiovascular effects of total hip placement were evaluated in 10 surgical patients, aged 55 to 82, while receiving fluroxene-N2O-O2 anesthesia. The anesthetic regimen caused mild cardiovascular depression. The placement of the acrylic cement into the acetabulum and femoral shaft also induced mild cardiovascular d... | 16,717 | [
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Erythrocyte adenosine triphosphate and 2,3-diphosphoglycerate after human renal transplantation: dissociation from hypophosphataemia. | 1. Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP) were determined in normal individuals, uraemic patients on chronic haemodialysis and patients who underwent renal transplantation, and correlated with plasma phosphate and arterial blood pH. 2. Significant increases in the 2,3-DPG and ATP ... | 16,718 | [
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Spontaneous variability of the hemoglobin affinity for oxygen. | In order to evaluate the accuracy of our method of P50 determination, we measured P50 and 2,3-DPG on different days on several members of our laboratory staff and were surprised to find significant variation. Initially, we indicted our methodology but subsequent data suggest that significant P50 variability occurs, not... | 16,729 | [
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Oxygen availability during hypothermic cardiopulmonary bypass. | Oxygen availability during cardiopulmonary bypass was assessed in 22 patients under hypothermic and relatively normothermic conditions. The patients were divided into two groups, 17 of whom received ACD blood and 5, CPD blood. The mean P50 for all patients fell from a preoperative value of 25.9 +/- 2.4 (SD) to 15.6 +/-... | 16,730 | [
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0.4482423,
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0.33921... |
Multi-clinic cross-over comparison of triazolam (Halcion) and placebo in the treatment of co-existing insomnia and anxiety in anxious out-patients. | In this multi-clinic double-blind cross-over designed study, forty-five anxious and insomniac out-patients received either triazolam (Halcion) 0.25 mg or placebo at bedtime. After seven days the medications were crossed over. The dosage was doubled after nights 2 and 9 if good sleep was not produced. Three patients dro... | 16,735 | [
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... |
The phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus aureus. 3. 1H and 31P nuclear-magnetic-resonance studies on the phosphocarrier protein HPr; tyrosine titration and denaturation studies. | The phosphocarrier protein HPr has been investigated by proton nuclear magnetic resonance (NMR) at 270 MHz in order to evaluate structural properties of the whole molecule and its active site. The titration behaviour of the three tyrosines of the HPr protein was analysed by monitoring the chemical shifts of the aromati... | 16,753 | [
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... |
Preference studies of triazolam with standard hypnotics in out-patients with insomnia. | One hundred and four patients suffering from insomnia took part in four different two-night double-blind crossover trials of triazolam. In three separate studies, triazolam 0-5 mg was compared to placebo, flurazepam 30 mg and chloral hydrate 500 mg. Triazolam 0-5 mg was found to be preferred and to be superior to place... | 16,801 | [
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0.3923676,
0.007046... |
Volume characteristics of extra- and intraparenchymal segments of the canine pulmonary artery. | The volumes of the extraparenchymal segment (VpaEP) and intraparenchymal segment (VpaIP) of the pulmonary arterial tree were determined in intact anesthetized dogs during room air breathing and acute hypoxia. Total pulmonary arterial blood volume (Vpatotal) was calculated as the product of pulmonary blood flow and pulm... | 16,859 | [
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0.1626... |
Actin-induced local conformational change in the myosin molecule. I. Effect of metal ions and nucleotides on the conformational change around a specific thiol group (S2) of heavy meromyosin. | As previously reported when a specific thiol group, S2, of myosin reacts with N-ethylmaleimide (NEM), its Ca2+-ATPase activity is decreased. Therefore, the reactivity of S2 can be estimated by measuring the decrement of the enzymatic activity. Using the change in the reactivity as a structural probe, we investigated wh... | 16,877 | [
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0.237019,
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Source of residual Bohr effect in hemoglobin oxidation. | The hemoglobin oxidation Bohr effect is larger than the ligation Bohr effect, even when the former is corrected for any ionization of the water molecule bound to the ferric iron of methemoglobin. This residual oxidation Bohr effect is here shown to be solely caused by the influence of the positively charged ferriheme, ... | 16,881 | [
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0.1126433,
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Bovine adrenal tyrosine hydroxylase: purification and properties. | Bovine adrenal tyrosine hydroxylase has been obtained in a form that is 85 to 90% pure. Sodium dodecyl sulfate-gel electrophoresis and density gradient centrifugation studies have established that the subunit molecular weight of the chymotrypsin-solubilized enzyme is 34,000. The presence of iron in the purified enzyme ... | 16,885 | [
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... |
Repressible alkaline phosphatase from Thermus aquaticus: associated phosphodiesterase activity. | A repressible alkaline phosphatase has been isolated from the extreme bacterial thermophile. Thermus aquaticus, and has been purified to homogeneity as judged by disc acrylamide electrophoresis and sodium dodecyl sulfate electrophoresis. Upon investigation, the purified enzyme was shown to hydrolyze certain phosphodies... | 16,900 | [
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0.4477125,
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0.176... |
Use of 1-anilino-8-naphthalene-sulfonate as a probe of gastric vesicle transport. | The interaction of 1-anilino-8-naphthalene-sulfonate (ANS) with vesicles derived from hog fundic mucosa was studied in the presence of valinomycin and with the addition of ATP. Evidence was found for two classes of sites, those rapidly accessible to ANS with a KD of 7.5 micronM and those slowly accessible, but rapidly ... | 17,006 | [
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... |
Costs and outcomes for different primary care providers. | This study examined the relationship between levels of medical training and direct costs for 1,700 episodes of acute illness treated in ambulatory-care clinics. Faculty, family practice residents, and physician assistants were included as the providers. Total cost and four component costs were examined. An outcome was ... | 17,020 | [
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Purification of histamine receptor. (IV) Specificity of binding of various drugs to the histamine receptor-rich fraction and to solubilized binding sites. | Studies were made on tritiated histamine binding to the receptor-rich membrane fraction and solubilized sites and its displacement by various drugs. H1-Agonists and antagonists displaced histamine most effectively. A H2-agonist and atropine were less effective and propranolol, phentolamine and imidazole acetic acid had... | 17,028 | [
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... |
[Prolongated amnesia after "rohypnol" i.v. before local anesthesia and responsiveness during operation (author's transl)]. | An up-to-eight-hour lasting anterograde amnesia is achieved by "Rohypnol" i.v. causing no excitation before local anesthesia is given (prolongation by analgetics, anesthetics, neuroleptics). The cardiovascular functions remain stable with spontaneous breathing and preservation of the swallow and coughing reflexes. Duri... | 17,038 | [
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0.307961,
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0.03892385,
0.3184416,
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Studies of yeast alcohol dehydrogenase with 3-aminopyridine monucleotide. | 3-Aminopyridine mononucleotide, a nicotinamide mononucleotide analog, was prepared by enzymatic cleavage of 3-aminopyridine adenine dinucleotide by a snake venom phosphodiesterase and isolated by means of ion exchange chromatography. The spectrophotometric and fluorometric properties of this analog were studied. Severa... | 17,065 | [
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A DNA nicking-closing enzyme encapsidated in vaccinia virus: partial purification and properties. | Vaccinia virus cores contain an activity which is able to relax both left-and right-handed superhelical DNA. This virus-specific nicking closing enzyme has been highly purified and differs from the corresponding host enzyme in salt optimum, in sedimentation coefficient, and in polypeptide composition as determined on s... | 17,115 | [
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[Desugarization of egg white by microorganisms]. | Glucose was eliminated from egg whites, using microorganisms, to prevent melanoidin formation which may damage the product. Desugarization was achieved by means of Acetobacter xylinum, Streptococcus lactis, Propionibacterium shermanii, Pr. petersonii and propionicacid cocci. Optimal conditions of desugarization were fo... | 17,113 | [
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0.3866693,
0.378206,
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[Migrating and recurrent superficial phlebitis and Takayasu's disease (apropos of a case)]. | This case of recurrent migratory superficial phlebitis is reported because of the highly unusual nature of the lesion observed. The picture was dominated by periphlebitis with inflammatory granuloma, giant cells and elastophagia. When the condition had been present for sixteen months, an aortic arch syndrome developed ... | 17,133 | [
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0.1016233,
0.01904696,
0.2361383,
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[Gastro-esophageal reflux disease. A review of pathogenesis, diagnosis and therapy]. | Gastro-esophageal reflux disease is caused by peptic damage from gastric contents to the distal esophagus. The principal cause of reflux is a decrease in pressure of the lower esophageal sphincter, which normally separates the esophagus from the stomach. Various hormonal, pharmacological or toxic agents are capable of ... | 17,158 | [
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0.05... |
[Beta blockaders and general pathology]. | The authors review the literature on the undesirable side effects of beta blockaders (excluding the cardiovascular system) and report the new therapeutic propects in psychiatry and in various metabolic disorders. The necessity of sufficient follow up made us choose propanolol as reference product without neglecting ace... | 17,162 | [
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0.167243,
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[Labilization of lysosomal and peroxisomal membranes in the kidneys preserved by transrenal gas perfusion]. | The total, free and unprecipitated activity of lysosomal (acid DNAase, acid RNAase, acid phosphate, acid beta-galactosidase) and peroxisomal (catalase, oxidase of D-amino acids) enzymes were studied in dog kidney cortex during storage of the tissues in solution of rheopolyglucin and under conservation of the kidney tis... | 17,222 | [
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... |
Contribution of arterial blood lactate measurement to the care of critically ill patients. | Arterial blood samples from 202 critically ill patients were studied. Lactate concentration, PO2, PCO2, pH, oxygen saturation, total CO2, and toe temperature were measured. Base excess, buffer base, actual bicarbonate, and standard bicarbonate were calculated. Analysis of the initial data obtained from each patient rev... | 17,295 | [
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[Gerontology in rural and mountains regions aged people in the country and in mountain regions (author's transl)]. | The gerontologic problems of people living in the country and in mountain regions always were neglected in comparison to those of townsmen. In the last decade an important structural change has happened, caused on the one side by the fact that more and more people leave the country for the towns, and by the problem of ... | 17,312 | [
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0.02649187,
... |
[Living conditions of the rural population in France. Situation in 1974 and evolution from 1967 to 1974 (author's transl)]. | A survey of the living conditions of aged people in rural regions of France in 1974 and a comparison with the previous surveys of 1967/68 in 302 rural vallages are analysed. Of the 4,800 persons in 1967/68, by 1974 1,609 were dead (35%). After questioning the 2,191 living persons (1,275 farmers and 916 non farmers) an ... | 17,314 | [
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0.451915,
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... |
Fungal growth on C1 compounds: quantitative aspects of growth of a methanol-utilizing strain of Trichoderma lignorum in batch culture. | A study was made of some salient parameters that influence growth of the methanol-utilizing fungus Trichoderma lignorum growing in batch culture on a minimal medium containing methanol as the sole source of carbon. Maximum cell yield was recorded at the expense of 1.58 g of methanol per liter. Inhibition was observed w... | 17,365 | [
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0.5832472,
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... |
Identification of the virucidal agent in wastewater sludge. | Anaerobically digested sludge contains an agent that causes irreversible inactivation of poliovirus. It has now been shown that the agent responsible for this activity is ammonia. The effect of ammonia on poliovirus appears to be typical for picornaviruses, but reovirus, an enteric virus of another group, is quite resi... | 17,367 | [
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0.1565643,
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... |
Haemagglutination tests in the study of Ascaris epidemiology. | Haemagglutination tests using adult Ascaris suum antigen were performed on sera from 810 people from three areas in Papua New Guinea and East Timor. In the area with the highest childhood Ascaris infection rates and egg-counts (Kaul), titres were highest and remained high throughout life. There was a significant negati... | 17,370 | [
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0.2963998,
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Blood serum peptidases in patients with ovarian carcinoma treated with Ledakrin. | The authors observed changes in activity of leucine amino-peptidase (E.C. 3.4.1.1--LAP), gamma-glutamyl transpeptidase (F.C 2.3.2.2--GGTP) and Co++-activated acylase in blood serum of patients with ovarian carcinoma, with or without ascites, treated with Ledakrin (1-nitro-9-[3-dimethylaminopropylamino] acridine). It wa... | 17,375 | [
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0.5426938,
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0.01185486,
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... |
The interaction of N-acetylhexosaminidase with insolubilized concanavalin A. | The specific interaction between human N-acetylhexosaminidase and concanavalin A was evaluated with respect to temperature, time, pH and concentration of specific ligand in incubation mixtures containing the enzyme and insolubilized lectin. Elution of the enzyme from insolubilized concanavalin A is dependent on both te... | 17,397 | [
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-0.006... |
[Treatment of coronary insufficiency with beta-receptor antagonists (author's transl)]. | The pathophysiology of the coronary insufficiency, the effect of beta-receptor antagonists, the understanding of these effects on the basis of the pathophysiology and the possibilities of testing beta-receptor antagonists in patients with coronary insufficiency are discussed. It is pointed out that the pathophysiology ... | 17,414 | [
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0.3511863,
0.2537161,
0.04344522,
0.0144... |
[Quantitative parameters of sympatho-neuronal and sympatho-adrenal activities in man. The influence of beta-receptor blocking agents (author's transl)]. | Determination of both catecholamine concentrations (norepinephrine and epinephrine) and the activity of dopamine-beta-hydroxylase in the plasma of health volunteers and hypertensive patients leads to the conclusion that these parameters used together can be considered an index for sympathetic neuronal activity. However... | 17,416 | [
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0.5091777,
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0.6147453,
0.08133731,
0.03020711,
-0.047... |
The bacteriology of skin cysts. | Thirty-nine clinically uninflamed cysts of the three most common varieties, epidermoid cysts, trichilemmal cysts and steatocystoma multiplex were removed under sterile conditions and the contents cultured under aerobic and anaerobic conditions. Seventy-three percent of epidermoid cysts grew significant numbers of organ... | 17,428 | [
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0.006186745,
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0.06620219,
0.4461899,
0.05811409,
... |
Beta-adrenergic receptor blocking drugs: tear lysozyme and immunological screening for adverse reaction. | Patients who had received long-term therapy with practolol and other beta-adrenergic receptor blocking drugs were examined ophthalmologically. Tear lysozyme concentration and serum autoantibodies (antinuclear antibodies, DNA-binding antibodies and intercellular cement substance antibodies) were measured. It was found t... | 17,431 | [
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0.1432991,
0.08603717,
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-0.2786197,... |
[Study of betacyanin-discolorating enzyme]. | An enzyme catalyzing the discoloration and breakdown of betacyanins was isolated from beet roots Beta vulgaris by centrifugation in sucrose density gradient (2.5 M, 2.0 M, 1.5 M, 1.0 M, tris-HCl buffer, 0.05 M, pH 7.2), and purified 100-fold. The enzyme activity induced the discoloration of betanin, betanidin. It was f... | 17,435 | [
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0.03728189,
0.4217907,
0.2030638,
0.4769322,
0.4654876,
-0.09938014,... |
The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon: implications in the pharmacology of antipsychotics and of a minor tranquilizer. | The turnover rate of GABA is measured in substantia nigra, globus pallidus, N. accumbens, and striatum of rats injected with muscimol, a potent GABA agonist, and diazepam. The similarity of action of the two drugs on GABA turnover further supports the theory that diazepam acts as a GABA-mimetic drug. Haloperidol and cl... | 17,436 | [
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0.01705603,
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0.257147,
0.002281496,
0.07374476,
-0.06415213,
... |
Suitability of some enrichment broths and diluents for enumerating cold- and heat-stressed Vibrio parahaemolyticus. | Vibrio parahaemolyticus cells were injured by chilling and heating, and their recovery was tested in glucose-salt-Teepol broth (GSTB), tryptic soy broth containing 7% NaCl (TSBS), Horie - arabinose - ethyl violet broth (HAEB), and water blue - alizarin yellow broth (WBAY). Exponential phase cells were more sensitive t... | 17,461 | [
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0.290945,
-0.0817835,
0.... |
Properties of 1-phosphofructokinase from Pseudomonas putida. | The 1-phosphofructokinase (1-PFK, EC 2.7.1.56) from Pseudomonas putida was partially purified by a combination of (NH4)2SO4 fractionation and DEAE-Sephadex column chromatography. In its kinetic properties, this enzyme resembled the 1-PFK's from other bacteria. With the substrates fructose-1-phosphate (F-1-P) and adenos... | 17,464 | [
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0.02930161,
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0.1125098,
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0.5236738,
-0.03654155,
-0.2086448,
0... |
Continuous-flow determination of serum inorganic phosphate with a single reagent--the vanadomolybdate method re-evaluated. | The merits of the vanadomolybdate method in the determination of inorganic phosphate are highly underestimated with regard to the simplicity of the method and the stability of both the reagents and the color that is formed. The absorption curve of the phosphovanadomolybdate complex, with its maximum at 335 nm, extends ... | 17,481 | [
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0.04600428,
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0.3062092,
0.2702494,
0.3175473,
-0.1109627,
0.50... |
Recent developments in the clinical assessment of the metabolism of aromatics by high-performance, reversed-phase chromatography with amperometric detection. | High-performance liquid chromatography with electrochemical detection has developed into a tool with excellent capability to monitor picomole amounts of individual metabolites in both tissue and body-fluid specimens. Significant technical advances in the area of microparticle chemically-bonded stationary phases have le... | 17,485 | [
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0.2210006,
0.1381384,
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... |
Flow cytometric measurement of peptidases with use of 5-nitrosalicylaldehyde and 4-methoxy-beta-naphthylamine derivatives. | Enzyme activity can be measured in single cells or in cell suspensions by either static or flow microfluorometry when a fluorogenic substrate is used. We have used amino acid derivatives of arylamines as fluorogenic substrates for tagging cellular proteinases. The liberated aromatic amine, which can diffuse from the ce... | 17,486 | [
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0.02800381,
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0.1364223,
0.5654272,
0.4936821,
0.2278982,
0.02417831,
0.05... |
The ventilatory response in uncomplicated diabetic ketoacidosis. | The ventilatory response to uncomplicated sub-acute metabolic acidosis was studied by measuring arterial blood CO2 tension (PaCO2) and pH in 27 episodes of diabetic ketoacidosis without coexisting lactic acidosis. From those data, regression equations and 95% confidence bands were calculated for the relations between P... | 17,514 | [
-0.1522645,
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0.2145315,
0.08689908,
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-0.156497,
0.002699124,
-0.01118... |
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