title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues during perinatal development. | The relative activities of uridine diphosphoglucuronyltransferase (UDPGT) and beta-glucuronidase (betaG) were measured during perinatal development of hepatic and extrahepatic tissues to determine the balance between glucuronidation and deglucuronidation reactions at different developmental stages. Liver, lung, kidney,... | 17,527 | [
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In vitro pharmacology of the opioid peptides, enkephalins and endorphins. | In the guinea-pig ileum methionine-enkephalin, normorphine and morphine are equipotent in depressing electrically evoked contractions; leucine-enkephalin has about 25% of the activity. The mouse vas deferens is more sensitive to the enkephalins which are 30 to 60 times more potent than morphine. Fragments of beta-lipot... | 17,538 | [
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Jejunal mucosal gamma glutamyl transferase activity in coeliac disease. | In view of data suggesting that deficiency of gamma glutamyl transferase (GGT) may be the primary abnormality in the small-intestinal mucosa of patients with coeliac disease, this enzyme was measured in mucosal biopsies from coeliac patients at different stages of treatment. Activity was only slightly reduced in only o... | 17,564 | [
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Nursing education in crisis: a computer alternative. | The impact of computer-assisted instruction upon the educational process is having its effect. The computer is being used in nursing education today to manage the educational environment, to instruct, to evaluate, to identify problem areas, to gather data, to manipulate data for research purposes and for continued educ... | 17,585 | [
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In vitro reconstitution of demolybdosulfite oxidase by molybdate. | Reconstitution of purified demolybdosulfite oxidase from rat liver has been achieved using inorganic molybdate as the source of molybdenum. The activation process has a pH optimum of 7.4 and is dependent on concentrations of molybdate and demolybdoenzyme. The reaction is inhibited by high concentrations of anions and b... | 17,611 | [
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Mullerian inhibiting substance in human testes after birth. | Tiny testicular biopsies from humans were assayed for Mullerian inhibiting Substances using a graded organ culture technique. Mullerian Inhibiting Substance activity was high during the first year of life, declined during the second year of life, and then disappeared. Mullerian Inhibiting Substance activity is lower in... | 17,665 | [
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The in vitro bioavailability of various drugs formulated as hard gelatin capsules. | A factorially designed experiment has been carried out to study the influence of various additives on the in vitro release of drug from hard gelatin capsules. Analysis of variance confirms previous findings that, although the main factors of diluent type, diluent concentration, the absence and presence of both magnesiu... | 17,668 | [
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The interaction between clonidine and various neuroleptic agents and some benzodiazepine tranquillizers. | The central hypotensive action of clonidine, infused into the vertebral artery of chloralose-anaesthetized cats was antagonized by several phenothiazine-neuroleptics (chlorpromazine, promazine, promethazine, thiethylperazine, thioridazine), by chlorprothixene and to a limited extent by haloperidol administered via the ... | 17,673 | [
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The enkephalins and opiates: structure-activity relations. | The X-ray structures of 9 "opiate" drugs which exhibit a range of pharmacological activity have been examined in detail leading to the theory that one of the reasons why the enkephalins and related peptides possess morphine-like activity is because they have a tyrosine, and hence a "tyramine", residue at the amino term... | 17,687 | [
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The identification and analysis of mexiletine and its metabolic products in man. | Sensitive and specific gas-liquid chromatographic methods were developed for the analysis of mexiletine and its metabolites in urine of man. The identity of the g.l.c. peaks was established by mass-spectrometry. The hydroxylamine (Va) was qualitatively identified and determined quantitatively after conversion to the mo... | 17,691 | [
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Determination of aqueous solubility and pKa values of estrogens. | Reported estrone pKa and solubility data show wide variation. Improved experimental procedures were designed and used to obtain reproducible results. The pKa values for several estrogens and related compounds also were determined to assess the effects of structural differences on ionization. No evidence was obtained fo... | 17,710 | [
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Determination of meclizine hydrochloride by ion-pair extraction with methyl orange. | A method, based on ion-pair extraction, is described for the quantification of meclizine hydrochloride in various pharmaceutical dosage forms, for content uniformity determination, and for concentration monitoring in dissolution and bioavailability studies. Methyl orange, dissolved in pH 2.8 MacIlvaine buffer, gave exc... | 17,714 | [
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Recording pH method of characterizing composition and monitoring dissolution profile of an anhydride-acid copolymer and its salt derivatives. | A sensitive potentiometric monitoring method was developed that permits the continuous measurement of the disolution profiles of methyl vinyl ether-maleic anhydride-acid copolymers and salt derivatives. Three distinct rate periods were observed in the dissolution rate of the anhydride copolymer, expressed as percent an... | 17,715 | [
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Kinetics of luminal acidification in cortical tubules of the rat kidney. | 1. Some kinetic aspects of renal tubular acidification were studied in proximal and distal tubules of the rat kidney by combining stationary microperfusion methods and continuous measurements of luminal pH changes of phosphate or bicarbonate buffers by means of antimony electrodes. The analysis included the measurement... | 17,736 | [
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Hyperpolarizing effects of dopamine on chemoreceptor nerve endings from cat and rabbit carotid bodies in vitro. | 1. The effects of dopamine on DC potential changes recorded from the carotid sinus nerve were studied in vitro using carotid bodies and associated sinus nerves removed from anaesthetized cats and rabbits.2. The carotid body was placed in one compartment of a superfusion chamber and was superfused with buffered salt sol... | 17,742 | [
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[Study of the nature of the associated microflora in the prolonged substrateless cultivation of beet plants]. | The purpose of the present investigation was to study variations in the population density of microorganisms, their qualitative and quantitative composition during substrate-free cultivation of beats. The results obtained show that the microbial number in the nutrient solution increased by the time of intensive growth ... | 17,774 | [
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[Thoracic injury and fat embolism]. | The authors state that fat embolism occurs rather frequently following thoracic injuries. It is difficult to make a diagnosis because of the complexity of the symptoms. The correct evaluation of the characteristic clinical and laboratory signs arising after a period free of symptoms is essential. The authors outline th... | 17,782 | [
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[Management of mass injuries in railway accidents]. | Authors write up the experiences they gained at repeated train accidents on the same section of railway line. The circumstances of the two accidents are evaluated and analysed. The experiences they obtained at the first accident were put to use the second time. The authors stress that the growing number of mass acciden... | 17,788 | [
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Non-equilibrium freezing behaviour of aqueous systems. | The tendencies to non-equilibrium freezing behaviour commonly noted in representative aqueous systems derive from bulk and surface properties according to the circumstances. Supercooling and supersaturation are limited by heterogeneous nucleation in the presence of solid impurities. Homogeneous nucleation has been obse... | 17,872 | [
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[Proof of guanylate cyclase activity in the coronary artery of cattle]. | Guanylate cyclase activities were identified in a soluble fraction and a particular fraction obtained from the Arteria coronaria of cattle. The Km-value was 1.0 +/- 0.7 - 10(-4) M for the enzyme substrate complex of the guanylate cyclase of the soluble fraction and 9.2 +/- 1.5 - 10(-4) M for the particular fraction. Fo... | 17,986 | [
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Bacteremia in hospitalized children. | The results of 6,951 blood cultures taken from hospitalized children are reviewed. One or more organisms grew from 6% (399) of the cultures, of which 189 (two thirds) were considered to represent confirmed bacteremia. The most common organisms associated with bacteremia were Haemophilus influenzae, Streptococcus pneumo... | 18,005 | [
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Function of human platelets during extracorporeal circulation. | The interaction between human platelets and nonbiologic surfaces was studied during in vitro recirculation of 500 ml of fresh, heparinized human blood in four different perfusion circuits. Circuits differed in surface area (0.1 m2 or 0.9 m2) and in surface composition. No important differences were observed between sta... | 18,017 | [
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[Dependence of diverticulosis on age (author's transl)]. | The diverticulosis of the gastrointestinal tract is a widespread senile disease. The dependence of the diverticulosis on age is investigated on the basis of 1 000 proven cases of this disease. The importance of the anatomicomorphological lesions of the organs at old age as its cause is pointed out. The males seem to be... | 18,032 | [
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Age-dependent alterations of the rate of RNA synthesis in rat brain cell nuclei. | Endogenous Mn2+ and Mg2+ activated RNA polymerase activity was measured in isolated cell nuclei of brain from rats of different age-groups. It was established that the activity of the nucleoplasmic RNA polymerase is maintained at the level of young animals up to an age of 16 months but is decreased after 24 months. The... | 18,035 | [
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[Hydroxylation of skin collagen in relation to age: analyses of the human skin]. | The results of human skin analysis are demonstrated. It has been pointed out, that the content of hydroxyproline and hydroxylysine, in addition to the usual variation as the other aminoacids varies extensively. The extent of hydroxylation was estimated from the relation of OH-aminoacids to (not hydroxylated) each other... | 18,040 | [
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[Behavior therapy in disorders of dietary behavior]. | Behaviour therapies using conditioning principles have been successful in the treatment of some psychopatological eating behaviours. Such have been the cases for anorexia nervosae in adolescents and adults, refusal to eat in the young child and difficulties of swallowing. Some of these cases are described. Research has... | 18,079 | [
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Azlocillin: in vitro studies of a new semisynthetic penicillin. | The activity of azlocillin, a new semisynthetic penicillin, was determined against 582 clinical isolates of gram-negative bacilli and gram-positive cocci. Over 75% of the isolates of Pseudomonas aeruginosa were inhibited at a concentration of 12.5 mug or less per ml. Azlocillin is also active against indole-negative an... | 18,083 | [
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Inheritance of muscle and liver types of supernatant NADP-dependent isocitrate dehydrogenase in rainbow trout (Salmo gairdneri). | The genetics of allelic variation for NADP-dependent isocitrate dehydrogenase (IDH-s) found in the supernatant of liver and white muscle extracts of rainbow trout (Salmo gairdneri) was examined. Twenty progeny from each of 50 controlled matings were examined for IDH phenotypes. Progeny data clearly indicated that the I... | 18,132 | [
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Purification and properties of urease from bovine rumen. | Urease (urea amidohydrolase, EC 3.5.1.5) was extracted from the mixed rumen bacterial fraction of bovine rumen contents and purified 60-fold by (NH4)2SO4 precipitation, calcium phosphate-gel adsorption and chromatography on hydroxyapatite. The purified enzyme had maximum activity at pH 8.0. The molecular weight was est... | 18,137 | [
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0.003321673,
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0.09511742,
-0.... |
Purification and properties of the NAD(P)H:nitrate reductase of the yeast Rhodotorula glutinis. | The assimilatory nitrate reductase from the yeast Rhodotorula glutinus has been purified 740-fold, its different catalytic activities have been characterized and some inhibitors studied. The purified enzyme (150 units per mg protein) contains a cytochrome of the b-557 type. An S20,w of 7.9 S was found by the use of suc... | 18,182 | [
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0.2494067,
... |
On the determination of isozyme levels in preparations containing cytoplasmic and mitochondrial aspartate aminotransferase. | A spectrophotometric assay has been developed for the determination of the content of each isozyme of aspartate transaminase (L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1) in physiological fluids or tissue extracts. The methods relies on the ability of adipate, at low pH and ionic strength to inhibit the cyt... | 18,183 | [
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0.5942754,
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0.07117525,
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Concerted inhibition of NADP+-specific isocitrate dehydrogenase by oxalacetate and glyoxylate. I. Oxalomalate formation and stability, and nature of the enzyme inhibition. | Oxalacetate and glyoxylate are each weak inhibitors of NADP+-specific isocitrate dehydrogenase (threo-DS-isocitrate:NADP+ oxidoreductase (decarboxylating), EC 1.1.1.42)9 Together, however, they act in a concerted manner and strongly inhibit the enzyme. The rates of formation and dissociation of the enzyme inhibitor com... | 18,195 | [
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0.09889962,
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Partial purification and some properties of gamma-glutamyl transpeptidase from human bile. | 1. Gamma-Glutamyl transpepetidase ((5-glutamyl)-peptide: amino acid 5-glutamyltransferase, EC 2.3.2.2) from human bile has been partially purified using protamine sulphate treatment, DEAE-cellulose chromatography and Sephadex G-200 filtration. The procedure resulted in 150-fold increase in specific acitivity with a 37%... | 18,198 | [
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... |
Purification and properties of a triacylglycerol lipase from Mycobacterium phlei. | In order to study the metabolism of triacylglycerol in mycobacteria, an intracellular particulate triacylglycerol lipase (EC 3.1.1.3) was purified 800-fold from stationary phase cells of Mycobacterium phlei. Extraction of whole cell suspensions with 5% Triton X-100, followed by ion-exchange chromatography of the extrac... | 18,200 | [
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... |
Characteristics of a cytochrome P-450-dependent fatty acid omega-2 hydroxylase from bacillus megaterium. | The fatty acid (omega-2) hydroxylase from Bacillus megaterium ATCC 14581 was examined with respect to some general enzymatic properties attributed to an intact complex isolated in a partially purified state. Hydroxylase specific activity was found to increase with increasing protein concentration in a manner consistent... | 18,202 | [
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0.1796791,... |
Amperometric assay of coenzyme-dependent oxidoreductase enzymes in a flow-through cell. | We have demonstrated that a simple electrochemical cell can serve as a detector of NADH concentration in a flow system thereby providing an assay technique for NADH dependent enzymes. When this is applied to NADH produced by enzymatic reaction, then a reproducible measure of enzyme activity is obtained. This method of ... | 18,231 | [
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0... |
[Inactivation of stem cells by allogenic lymphocytes: competition between T1- and T2-subpopulations]. | Transplantation of the bone marrow cells with allogeneic T-lymphocytes to the irradiated hosts was accompanied by inactivation of the stem elements of the graft. The lymph node cells of T-mice (those deprived of B cells) were more active than the spleen cells of these mice. The stem cells inactivation was weakly expres... | 18,238 | [
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0.007987677,
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The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs. | 1 The relative efficacies of three trachea-atria selective beta-adrenoceptor agonists, fenoterol, Me 506 and Me 454, compared to isoprenaline, were determined on both trachea and atria of guinea-pigs. 2 On tracheal preparations the beta-adrenoceptor agonists were used as functional antagonists of carbachol and a compar... | 18,249 | [
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Characteristics of potassium ion transport in pea cotyledon mitochondria isolated by a zonal technique. | Methodology was developed for measurement of K+ transport in pea cotyledon mitochondria isolated by zonal centrifugation. The valinomycin-mediated transport process required respiratory energy from Krebs cycle intermediates and was completely reversible in the absence of oxygen. The rate and extent of uptake were depen... | 18,268 | [
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0... |
The tricarboxylic and acid pathway in Desulfovibrio. | Strains of two species of Desulfovibrio were examined for enzymes of the tricarboxylic acid cycle and related pathways. Pyruvate carboxylase (EC6.4.1.1) is present, and alpha-ketoglutarate is formed via the tricarboxylic acids. Glutamate, but not succinyl-CoA, arises from alpha-ketoglutarate. A pathway exists from pyru... | 18,274 | [
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0.022... |
Weekly methotrexate-calcium leucovorin rescue: effect of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS non-Hodgkin's lymphoma. | Urinary alkalinization with oral sodium bicarbonate has decreased the incidence of acute nephrotoxicity and subsequent myelotoxicity in 18 adults receiving high-dose methotrexate with calcium leucovorin rescue (MTX-LCV) weekly in doses of 1-7.5 g/m2. Close monitoring of 24-hour serum creatinine and MTX levels can predi... | 18,282 | [
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0.2153541,
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[Interaction of thymic cells and hemopoietic stem cells. Enhancing effect on irradiated thymus repopulation]. | In irradiated mice engrafted with hemopoietic cells, the thymus is repopulated more rapidly by bone marrow-derived than by spleen-derived cells. Admixing thymic cells with the restorative suspension stimulates the thymic repopulation by spleen-derived cells whereas it has no effect on the repopulation by bone marrow-de... | 18,294 | [
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0.1642746,... |
Properties of the thyroxine (T4) monodeiodinating system in rat liver homogenate. | The monodeiodination of T4 in rat liver homogenate was studied. The two possible products of this reaction show very different properties. The metabolically very active T3 is rather stable in this system whereas the biological inactive reverse T3 (rT3) disappears very rapidly. This explains the low apparent rT3 product... | 18,299 | [
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0.05... |
A new method for peptidase activity measurement in serum and tissues, using L-Leu-L-Leu as substrate. | Peptidase-free L-amino-acid oxidase was purified from venom of Agkistrodon caliginosus and was used for the determination of serum peptidase (EC 3.4.1.-) activity with L-Leu-L-Leu as substrate. The peptidase activity in human serum rose remarkably in liver diseases, and had a significant correlation with serum transami... | 18,304 | [
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Testicular androgen binding protein (ABP) - a parameter of Sertoli cell secretory function. | Using ABP as an index of Sertoli cell secretory function, several important features of the Sertoli cell have emerged: 1. The stimulation of ABP production by FSH clearly points to the Sertoli cell as a target cell for FSH (3,4,9-16,21,24). 2. The dramatic effects of androgens on ABP production both in immature and mat... | 18,322 | [
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... |
Nickel cytochrome c. Effect of protein moiety on the metal ion coordination. | Nickel cytochrome c has been synthesized by the reaction of metal-free porphyrin cytochrome c with Ni(II) ions in 0.6 Mglycylglycine and 4 M KSCN. Electronic spectra and susceptibility measurement showed the nickel to be in a high-spin octahedral configuration exemplifying the strong influence of the protein moiety as ... | 18,352 | [
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0.3... |
Phosphate uptake and involvement of binding protein in Tween-80 supplemented culture of Aspergillus fumigatus. | Tween-80 supplementation in submerged culture of Aspergillus fumigatus resulted in an increase of phosphate uptake. The uptake system was characterized as saturable, energy-dependent and operating against the concentration gradient. Control and Tween 80 cultures showed similar Km values for phosphate uptake (50 microme... | 18,385 | [
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[Purification and properties of the tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris) (author's transl)]. | The tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris) has been purified 80-fold by ion exchange chromatography and gel filtration. Optimal methyl transfer is found at pH 6.5 and 39 degrees C. Even at 0 degrees C, however, a considerable catalytic rate is observed. The Michaelis-Menten c... | 18,397 | [
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Testosterone production and metabolism in laboratory-maintained male rhesus monkeys. | Plasma production rates (PR), metabolic clearance rates (MCR) and plasma levels of testosterone were determined in 10 male, laboratory-maintained rhesus monkeys on two occasions out-of-season (April and August) and once in-season (October). Plasma testosterone levels in October were higher than those in April and Augus... | 18,415 | [
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Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women. | The LH FSH estradiol and progesterone responses to acute stimulation with LH-RH were studied in 12 normal women with ovulatory cycles (4 in the initial follicular phase, 4 in the mid-follicular phase and 4 in the late follicular phase) and in two castrated women, two under hormonal contraception, two with ovarian ameno... | 18,416 | [
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0.... |
Interpretation of thermal perturbation spectra of proteins. | The thermal perturbation difference spectrum of reduced lysozyme has a long wave length extremum at 304 nm at pH 6.15 and a very small extremum at 306 nm at pH 1.5. These results differ from those of Leach & Smith (1972), which showed an extremum at 293 nm, the same as for model tryptophyl compounds. Our result may... | 18,420 | [
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... |
Chemical modifications of ribonuclease U1. | In order to obtain information on the nature of the amino acid residues involved in the activity of ribonuclease U1 [EC 3.1.4.8], various chemical modifications of the enzyme were carried out. RNase U1 was inactivated by reaction with iodoacetate at pH 5.5 with concomitant incorporation of 1 carboxymethyl group per mol... | 18,450 | [
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0.049... |
The activity of the pneumococcal autolytic system and the fate of the bacterium during ingestion by rabbit polymorphonuclear leukocytes. | The extent to which autolytic microbial enzymes are involved in the fate of microorganisms ingested by phagocytes has not been determined. It is known, however, that activation of degradative enzymes occurs during certain microbicidal events. We examined the possible role of the pneumococcal autolytic enzyme (an N-acet... | 18,480 | [
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... |
Hypopotassemia following open heart surgery by cardio-pulmonary bypass. | 1. In this study where potassium concentration of perfusate of heart-lung machine was made high and no potassium was given until two hours after by-pass, the fall of plasma potassium level due to heart-lung bypass occurred in two stages, namely one hour of complete bypass and two hours after the end of bypass. 2. Regar... | 18,478 | [
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0.1094142,... |
An analysis of the professional performance of physician's assistants. | The job performance of a national sample of 939 physician's assistants has been assessed by means of a self-rating scale as well as by a rating scale completed by supervising physicians. Three-quarters of the participating supervising physicians are greatly satisfied with the work of their physician's assistants and a ... | 18,608 | [
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0.1269984,
-... |
Nephropathia epidemica. The Scandinavian form of hemorrhagic fever with renal syndrome. | We report epidemiologic, clinical, laboratory, and biopsy findings in 14 cases of nephropathia epidemica. The patients were between 19 and 49 years of age. The onset of the disease was characterized by high fever, nausea, headache, backache, abdominal pain, proteinuria, oliguria, hematuria, and uremia. The symptoms sub... | 18,620 | [
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Porphyrin biosynthesis. Immobilized enzymes. IV. Studies on aminolaevulate dehydratase attached to Sepharose. | Bovine liver aminolaevulate dehydratase (ALA-D) has been chemically attached to Sepharose 4B and its properties have been studied. The optimal conditions for coupling have been determined. It was found that the immobilized enzyme retained a significant percentage of the activity of the free enzyme. The coupling yield w... | 18,669 | [
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Phosphohistone and glycogen synthase D phosphatase activities in a liver glycogen pellet preparation. | A liver glycogen pellet preparation previously found to contain synthase D phosphatase activity was shown to contain also phosphohistone phosphatase activity. Pellet phosphohistone phosphatase and synthase D phosphatase competed for the same substrates and appeared to be the same enzyme. ATP, a potent inhibitor, and G-... | 18,746 | [
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Assay and characterization of serum-stimulated lipolytic activity in homogenates of human adipose tissue. | An assay of lipolytic activity in human adipose tissue is described, in which native homogenates of the adipose tissue yield the enzyme, as well as the triglyceride substrate, and the emulsifying phospholipids. The lipolytic activity in the presence of serum is characterized mainly as lipoprotein lipase activity by a p... | 18,766 | [
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A deficient pyruvate kinase with an electrophoretically slow-moving component. | A deficient erythrocyte pyruvate kinase observed in a patient with congenital non-spherocytic anaemia was characterized by the following properties: very low activity in haemolysates, decreased thermal stability, slightly increased urea denaturation, high affinity for PEP, poor FDP activation, normal ATP inhibition, de... | 18,793 | [
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[Immunosuppressive properties of vinblastine and colchicine]. | The action of vinblastine and colchicine on the populations of antibody-forming cells, their precursors and stem cells using a model of primary immune response and in the transplantation system was studied using techniques by Jerne and Nordin (1963), Kennedy et al. (1965), and Till and McCulloch (1961). It was discover... | 18,824 | [
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[Properties of chymotrypsin proteinase from Aspergillus oryzae]. | Chymotrypsin-type proteinase is detected in the proteolytic system of Asp. oryzae. The action of it and chymotrypsin is shown to depend on formaldehyde. Hydrolysis of substrates, p-nitrophenyl acetate (p-NPA) and N-benzoyl-tyrosine methyl ether (BTME), by both preparations is almost the same. The obtained activity pH-o... | 18,830 | [
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[Detection and quantitative estimation of 2,2-diethyl-4-pentenamide in a fatal case of poisoning (author's transl)]. | Toxicological investivation in a fatal case of poisoning by Novo-DolestanR and DoromaR is presented with methods for identification and quantitative estimation of 2,2-diethyl-4-pentenamide especially. The findings confirm 2,2-diethyl-4-pentenamide as the main toxic agent in this case. | 18,861 | [
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[Behavior therapy of fear of flying in professional pilots]. | The theorical frame proposed by behaviour principles seems to have an explanatory value in the genesis of some troubles of traumatic origin. This is the case for fear of flying which can appear suddenly in airline personnel following accidents, troubles or problems while flying and which could bring a definitive incapa... | 18,875 | [
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Syntheses of virus-induced thymidine kinase and viral DNA in herpes simplex type 1 virus-infected chick embryo fibroblasts. | Herpes simplex virus type 1, strain Kupka, did not replicate in chick embryo fibroblasts (CEF), but the infection was followed by the development of cytopathic changes. This effect could be abolished by UV irradiation of the virus. Virus-induced thymidine kinase was synthesized in the infected cells reaching a maximum ... | 18,914 | [
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Differential expression of D and R components of Epstein-Barr virus early antigen after superinfection and after induction with 5-iododeoxyuridine. | Three non-productive human lymphoblastoid cell lines, NC-37, RAJI and L-1, either superinfected with Epstein-Barr (EB) virus from P3HR-1 cells or treated with 5-iododexyuridine (IUDR), were studied for the development of early antigen (EA) of EB virus. In all three superinfected cell lines, both the restricted (R) and ... | 18,915 | [
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... |
Analysis of antibody response and immunoglobulins in sera of rabbits and guinea pigs immunized with Coxiella burnetii. | Rabbit and guinea pig sera and their immunoglobulin fractions (IgM and IgG) were examined by complement-fixation (CF), microagglutination (MA), opsonization-phagocytosis (OP) and serum protection (SP) tests at intervals after immunization with live phase I and phase II Coxiella burnetii suspensions. In general, MA anti... | 18,924 | [
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The effects of purified cathepsin D infusions in intact animals. | Cathepsin D, a potent acid proteinase, has been implicated in the pathogenesis of circulatory shock. The infusion of purified preparations of cathepsin D into intact animals resulted in significant depressions in core body temperature but failed to reproduce the cardiovascular disturbances seen in shock states. | 18,942 | [
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[Toxico-pharmacological study of lyophilized sodium nitroprusside (SNP)]. | Sodium nitroprusside (SNP) shows a strong hypotensive activity not only in normotensive animals but also in the presence of experimentally induced arterial hypertension. Its use in intravenous perfusion produces the rapid induction of arterial hypotension lasting or only slightly exceeding the time of its administratio... | 18,961 | [
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[Changes in serum and urinary magnesium during and after extracorporeal circulation in cardiac surgery in children]. | Magnesium plays an essential role in the processes of myocardial contraction and conduction. In cardiovascular surgery, extracorporeal circulation (ECC) in haemodilution results in various electrolyte distrubances, with invariably hypomagnesaemia. A group of 13 children undergoing open heart surgery was compared with a... | 18,967 | [
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Rapid induction of alpha-amylase by nongrowing mycelia of Aspergillus oryzae. | A rapid induction system for synthesis of alpha-amylase by the funga Aspergillus oryzae M-13 was established. The mycelia were prepared from 20-h cultures grown on a peptone-glycerol medium and starved for 5 h; maltose was the optimum inducer tested. During h 1 of induction, formation of both intra- and extracellular a... | 18,989 | [
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[Studies on the thiamine transport system in Bacillus cereus (author's transl)]. | The thiamine transport system in Bacillus cereus exhibits rhythmical changes of resorption- and excretion-phases lasting 1-2 h. These main phases are subdivided in shorter ones with an average duration of 45 s. The velocity of the thiamine uptake is influenced by pH, temperature, age of cells, energy and substrate supp... | 19,001 | [
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Substitute and alternative neurotransmitters in neuropsychiatric illness. | The accumulation of structural analogs of normal synaptic neurotransmitters (substitute or "false" neurotransmitters) can have profound behavioral and neurologic consequences. Such abnormalities of the metabolism of amines and amino acids may explain behavioral and neurologic changes in hepatic failure. Accumulations o... | 19,004 | [
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Respiratory effects and amnesia after premedication with morphine or lorazepam. | Lorazepam, a new benzodiazepine, was compared with morphine for premedication. Ten patients received morphine 10 mg/70 kg i.m. and 10 received lorazepam 4 mg/70 kg i.m. Respiratory effects were assessed from the change in slope (S) and intercept (B) of the carbon dioxide response line, using a development of Read's reb... | 19,025 | [
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Circular dichroism and conformation of human alpha1-antitrypsin. | The solution conformation of alpha 1-antitrypsin from human blood plasma was studied by the circular dichroism (CD) probe. The CD spectra revealed in this glycoprotein approximately 16-20% of alpha-helix, the rest of the main polypeptide chain possessing the pleated sheet (beta) and the aperiodic structures. The confor... | 19,086 | [
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[Malic acid induction of decarboxylating NADP-malate dehydrogenase synthesis in C3-plant leaves]. | The activity of decarboxylating NADP-malatedehydrogenase (E. C. 1.1.1.40) in green ethiolated pea and barley leaves and in green leaves of a pea mutant lacking photosystem II is found to be 3-fold increased after the injection of malic acid into cut plants. Protein synthesis inhibitors depressed malic acid-induced incr... | 19,098 | [
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Structure and fragmentation mechanisms of some ions in the mass spectrum of ephedrine. | This paper describes the use of gas chromatography mass spectrometry for the confirmation of ephedrine in adulterated powdered ipecac and ipecac fluid extract. Deuteration studies of ephedrine hydrochloride and some related compounds were also performed in an attempt to postulate structures for some of the fragment ion... | 19,109 | [
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Process engineering studies on immobilized trypsin using molecular sieves as carriers. | In the present investigation molecular sieve has been found to be a suitable carrier for the immobilization of enzymes. From the present study it may be specifically found that trypsin and pappain can be immobilized by molecular sieve type 4a following a very simple techniqure. The immobilized enzyme can be used both i... | 19,110 | [
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The inhibition of calcium oxalate crystal growth by multidentate organic phosphonates. | The effect of a number of structurally related multidentate organic phosphonates on the rate of crystal growth of calcium oxalate was studied as a function of pH. Rate constants were obtained at various concentrations for the phosphonates ethane-1-hydroxy-1,1-diphosphonate (EHDP), nitrilotri(methylenephosphonic acid) (... | 19,137 | [
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Future of anesthesia. | The authors present an account of some of the problems facing the specialty of anesthesia, which suggests that the interdependence of these problems and of their solutions should be recognized. Recruitment, job satisfaction and clinical standards will be improved as a result of greater involvement by anesthetists in pr... | 19,147 | [
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... |
Desensitization therapy for body image anxiety. | A newly devised therapy technique to desensitize individuals for body image anxiety arising from conversion symptoms and psychophysiologic disorders is outlined. One application involves the projective use of inkblots with high anatomical content which provide a source of visual input to stimulate somatic images in con... | 19,149 | [
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The nature of the rate-limiting step in aniline hydroxylation involving cytochrome p-450 rat liver microsomes. | The kinetics of aniline hydroxylation was studied with: (1) rat liver microsomes involving NADPH and O2 (system 1), (2) hepatic microsomes and tert-butylhydroperoxide (system 2) and (3) microsomes and cumyl hydroperoxide (system 3) at 15--37 degrees C. The reactions were characterized by the values of the aniline oxida... | 19,154 | [
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Creatine kinase: re-examination of optimum reaction conditions. | I have re-examined optimum reaction conditions for measurement of creatine kinase (EC 2.7.3.2). The optimum pH is 6.45, and 2,2-bis(hydroxymethyl)-2,2',2''-nitrotriethanol acetate, 200 mmol/liter, is the buffer of choice. Thioglycerol, 20 mmol/liter, is superior for both in-assay reactivation and for storage stability ... | 19,166 | [
-0.2229404,
0.3257935,
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-0.4446335,
0.05468023,
-0.04645309,
-0.2123154,
0.332238,
-0.08340137,
-0.2737594,
0.211814,
0.1828176,
0.1902778,
0.6817423,
-0.3219184,
-0.199129,
-0.3911733,
0.05077416,
-0.0483954,
0.3948513,
0.2434955,
-0.08860217,
-0.08022133,
0... |
Calcium in bile and calcium salts in gallstones. | In gallbladder and common duct bile from patients undergoing cholecystectomy, usually because of gallstones, calcium was found to exist in at least 2 forms. Ultrafiltration showed some calcium was bound to substances with a molecular weight greater than 10 000, and the chief binding agent is likely to be the mixed mice... | 19,175 | [
-0.1058584,
0.627478,
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0.127365,
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0.1211753,
0.03808229,
0.398371,
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0.2620864,
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0.115669,
0.3528735,
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0.3299931,
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0.05819558,
0.29... |
Equine angiotensin converting enzyme: a zinc metalloenzyme. | 1. Angiotensin I converting enzyme from horse plasma has been extensively purified and shown to be homogeneous by disc-gel electrophoresis. 2. The metal ion involved in the catalytic reaction of the enzyme has been identified for the first time as zinc by atomic absorption spectrometry. 3. A number of other physicochem... | 19,186 | [
-0.3211319,
0.1190016,
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0.1459684,
0.08526792,
0.1412722,
0.2085488,
0.2093225,
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... |
The interrelationship between the metabolism of (S)-continine-N-oxide and (S)-cotinine. | The metabolism of (S)-cotinine-N-oxide was studied in the rabbit and the dog. The pattern of Koenig-positive substances in the urine of the animals suggested the presence of cotinine, demethylcotinine, hydroxycotinine, and allohydroxycotinine, compounds already previously identified as metabolites of (S)-cotinine and (... | 19,214 | [
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0.09516589,
0.2920085,
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0.186275,
0.638319,
-0.3016966,
0.02058398,
0.3169559,
0.08388308,
-0.... |
Estradiol binding capacity in the cryptorchid rat testis. | Mature male Sprague-Dawley rats were made surgically cryptorchid at 47--50 days of age. Animals were sacrificed as controls and at 7, 14, and 21 days post-surgery. The testes were removed and utilized to determine the effects of cryptorchidism on tissue weight loss, histological changes, and cytoplasmic estradiol bindi... | 19,233 | [
0.08579214,
0.06711846,
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0.194183,
0.4566975,
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0.1840674,
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0.3685473,
0.4396333,
-0.0308024... |
Possible role of calcium-dependent protein phosphorylation in mediating neurotransmitter release and anticonvulsant action. | The results demonstrate that calcium and phenytoin have antagonistic actions on the net level of endogenous phosphorylation of specific rat brain proteins. These specific phosphoproteins were shown to be present in synaptosome preparations, and evidence is presented for the localization of these phosphoproteins within ... | 19,235 | [
0.01301016,
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0.2983334,
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-0.2773224,
0.009108051,
0.05594947,
0.135694,
-0.0356256,
0.2395842,
0.0323... |
Bacteriorhodopsin-mediated photophosphorylation in Halobacterium halobium. | The rate of halobacterial photophosphorylation was found to be a linear function of light intensity over a wide range (between 1 and 20 mW/cm2). At higher light intensities (above 25 mW/cm2) the ATP-synthesizing system itself limits the maximal rate of photophosphorylation. The optimal external pH range for this type o... | 19,249 | [
-0.1897653,
0.07370996,
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0.3607939,
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0.1094781,
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0.04622557,
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0.5590597,
0.07693325,
-0.03773174,
... |
Hemoglobin S Travis: a sickling hemoglobin with two amino acid substitutions [beta6(A3)glutamic acid leads to valine and beta142 (h20) alanine leads to valine). | Hb S Travis is a previously undescribed sickling hemoglobin with two amino acid substitutions in the beta chain: beta6 Glu leads to Val and beta142 Ala leads to Val. The beta6 Glu leads to Val mutation imparts to Hb S Travis the characteristic properties of sickling hemoglobin, namely its association with erythrocyte s... | 19,257 | [
-0.3427091,
-0.09036435,
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0.1294335,
0.07541166,
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0.2005533,
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0.4480858,
-0.1... |
Regional effects of neuroleptics on dopamine metabolism and dopamine-sensitive adenylate cyclase activity. | The effect of haloperidol, chlorpromazine, thioridazine and sulpride on the levels of DOPAC and HVA, as an index of DA turnover, and on the activity of DA-stimulated adenylate cyclase was investigated inthe striatum, the nucleus accumbens and the tuberculum olfactorium of the rat brain. Haloperidol, chlorpromazine and ... | 19,266 | [
-0.2371425,
-0.1909619,
-0.2185954,
-0.1715093,
0.2261503,
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0.2354125,
0.1103492,
0.0003788022,
0.01403551,
0.287511,
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-0.6506554,
0.02889272,
0.2291308,
0.1739524,
0.1275095,
0.3496256,
0.02213539,
... |
Interaction of extrinsic fluorescent probes with E. coli glutamine synthetase. | Binding of 2-p-toluidinylnaphthalene-6-sulfonate (TNS) to adenylylated (E--11) glutamine synthetase is cooperative and time-dependent, with 3 dye sites per subunit. In fluorescence polarization experiments TNS and pyrene butyrate give normalized Perrin plots that indicate a symmetrical arrangement of dye excited state ... | 19,281 | [
-0.1961646,
0.366044,
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0.3736206,
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-0.07126141,
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0.14329,
0.129061,
0.3070124,
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0.04124866,
0.01192042,
0.1859248,
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0.0742631,
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0.2325103,
-0.3922763,
0.2768482,
0.1806418,
0.1160842,
-0.002285595,
-0.052... |
Chemical studies of marine invertebrates. XXVII. On the absolute configuration of aromadendrane sesquiterpenes from the soft coral Cespitularia aff. subviridis. | Allo-aromadendrene, (-)viridiflorol and (+)ledol have been identified as minor constituents of the soft coral Cespitularia aff. subviridis. | 19,283 | [
-0.1740138,
0.2826593,
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0.06165924,
0.1404657,
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0.3803142,
0.3980201,
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0.2121968,
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0.4352786,
0.1212317,
0.1843821,
-0.3047352,
... |
Hydrogen ion and carbon dioxide content of the oviductal fluid of the rhesus monkey (Macaca mulatta). | The pH in the oviduct lumen of adult female rhesus monkey (Macaca mulatta) during the menstrual cycle was measured by means of miniaturized pH electrodes. Two types were used: one was a flexible electrode 1.4 mm in diameter; the other was a rigid electrode 0.8 mm in diameter. The same results were obtained with both ty... | 19,307 | [
-0.08028223,
0.1298686,
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0.08337992,
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0.1528276,
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0.01850014,
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-0.02960802,
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0.4106651,
0.08232222,
0.3704899,
0.04931291,
0.0837800... |
Antihypertensive effect and tolerability of metoprolol during long-term treatment: a multicentre study. | One hundred and forty-seven patients with essential hypertension participated in this multicentre study. The results indicate that metoprolol in a dosage of 150-450 mg daily is an effective and well tolerated therapy both in patients previously untreated and in patients unsatisfactorily treated with other antihypertens... | 19,328 | [
-0.09523638,
0.06327493,
-0.1809543,
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0.0003712031,
-0.2878024,
-0.3241335,
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0.02019871,
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0.2731965,
0.0813957,
0.150867,
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-0.2762052,
0.3119282,
-0.1988953,
0.1228231,
-0.1586269,
0.1383757,
-0.0210433... |
Crohn's disease involving the colon: an audit of clinical management. | This paper describes the clinical management of 204 patients with Crohn's disease involving the colon who have been reviewed regularly for many years. The results have been analyzed to define the morbidity, mortality, and long term prognosis of the disorder. Despite a high morbidity, the long term prognosis is good. Al... | 19,340 | [
-0.1299522,
-0.1370941,
-0.03234587,
-0.2640734,
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-0.1434336,
0.02775282,
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0.131605,
0.2243516,
0.0009893103,
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-0.2041829,
0.04510782,
0.1404617,
0.1087999,
0.1108751,
0.2359131,
-0.0870830... |
Effect of acetylsalicylic acid on the amphibian gastric mucosa. I. Electrophysiological and permeability changes. | The effects of acetylsalicylic acid on the in vitro bullfrog gastric mucosa were defined. After mucosal exposure of 10 or 20 mM acetylsalicylic acid, a characteristic series of changes evolved. The potential difference and resistance rose initially. After 15 to 30 min the potential difference declined to zero. Transmuc... | 19,341 | [
0.08326764,
-0.481133,
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0.1117103,
0.05588768,
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0.2412868,
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0.05880443,
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0.2059501,
0.0006380349,
0.1257535,
0.3147845,
-0.02385025,
0.09411719... |
Interaction of colchicine with DNA molecules. | Colchicine (7.5 X 10-6M or 3.3 X 10-5M) was incubated at pH 7.0, 10.0, or 12.0 with high-molecular DNA from salmon sperm (7 X 10-5M or 3.5 X 10-5M DNA-P) at 40 degrees C. Interaction was monitored by UV spectrophotometry; Amax/Amin ratios, difference and additive spectra, and the quantity of colchicine bound to DNA wer... | 19,350 | [
-0.1895228,
0.277804,
-0.3027574,
0.122701,
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0.08137178,
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0.2282516,
0.2220341,
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0.07940991,
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0.4974537,
0.6804622,
-0.3862472,
-0.03209797,
-... |
Some properties of hemoglobin Gun Hill. | Hb Gun Hill has been found in an asymptomatic black female living in Alabama; neither her parents nor her two siblings carry the variant. The deletion of five amino acid residues in the beta chain of Hb Gun Hill (alpha2beta2 91-95 deleted) causes this variant to have a high oxygen affinity, an interaction coefficient o... | 19,375 | [
-0.2564658,
0.08388088,
-0.4819271,
0.1696315,
0.162304,
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0.2078976,
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0.1542653,
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0.1053335,
0.4756441,
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0.3267732,
0.3581304,
0.05137818,
... |
Aminoglycoside nephrotoxicity. I. Effects of aminoglycoside antibiotics on iodohippurate accumulation in rabbit renal cortical slices. | The effects of aminoglycoside antibiotics on the accumulation of O-125I-hippurate (OIH) in rabbit renal cortical slices were assessed in an attempt to establish an in vitro model for aminoglycoside nephrotoxicity. Accumulation of OIH was measured after incubation of cortex slices in media containing aminoglycosides in ... | 19,410 | [
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0.2414999,
0.2042461,
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0.4363216,
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0.03771797,
0.2653056,
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0.09716315,
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0.4627856,
-0.1259597,
0.3749157,
0.3361673,
0.3417277,
0.1380074,
-0.... |
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