title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The role of calcium and cyclic adenosine 3',5'-monophosphate in the regulation of glycogen metabolism in phagocytozing human polymorphonuclear leukocytes. | Incubation of human polymorphonuclear leukocytes in a glucose-free Krebs-Ringer bicarbonate buffer for 2 h resulted in glycogen depletion, decreased phosphorylase activity and increased synthase-R activity. Addition of dialyzed latex particles to starved leukocytes revealed a very rapid ingestion rate (half-maximal ing... | 208,651 | [
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[Effect of ferricyanide, dark adaptation and aging on the properties of the EPR I signal of chloroplasts]. | Ferricyanide (10-3 M) is shown to oxidize from 25 to 50% of the total P700 pool in the dark. The ferri-ferrocyanide mixture thus obtained, acting as redox buffer, accelerates the P700+ dark reduction after continuous far red illumination is turned off or after a saturating flash. The oxidized P700 yield on the flash in... | 208,654 | [
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NMR studies of electron carrier proteins from sulphate reducing bacteria. | The sulphate-reducing bacteria have a complex electron transfer system which leads to the reduction of sulphate by oxidation of either organic substrates or molecular hydrogen. These bacteria can either produce or consume molecular hydrogen. The central part of this electron pathway for Desulovibrio gigas is constitute... | 208,661 | [
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[Hematopoietic tissue reactions associated with the growth of syngeneic transplanted tumors in mice]. | Hemangiopericytoma growth in syngeneic male mice F1 (CBA X C57BL/bj) led to regular hemopoietic changes: an increase in the spleen weight, spleen cell count, in the number of colony-forming units (CFU). It also induced augmentation of myelopoiesis in the spleen and leukocytosis with a sharp increase of segmented granul... | 208,682 | [
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Effects of releasing factors on hypothalamic neurones. | Our previous reports on the effect of locally applied polyeptides such as ACTH, the releasing factors TRF and LRF on single unit activity of hypothalamic neurones have been confirmed and extended by several workers. These polypeptides also exhibit behavioural effects. The concept that such hormonal polypeptides may exe... | 208,697 | [
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The auditory midbrain of a marsupial: the brush-tailed possum (Trichosurus vulpecula). | A microelectrode survey was made of the midbrain auditory nuclei of the brushtailed possum (Trichosurus vulpecula), a common Australian marsupial. Information was sought on the tuning characteristics of individual neurones, tonotopic organization and mechanisms of sound localization. It was felt that such information w... | 208,715 | [
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Radiation induced free radicals as molecular probes in synthetic apatites. | Free radicals generated in synthetic apatitic calcium phosphates by X-ray radiation were investigated by electron spin resonance (ESR) spectroscopy. Among the species stable enough at -188 degrees C to be identified were hydrogen atoms, phosphate radicals, and oxygen anion radicals. The ESR spectra were markedly depend... | 208,721 | [
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Preparation of cell populations with stabilized erythropoietic potential from the primitive streak chick blastodisc: some implications for control of gastrulation. | Improved methods for preparation from primitive streak chick blastodiscs of cell suspensions capable of forming erythroid cells in culture have been developed. When blastodiscs were preincubayed with hyaluronidase in the absence of collagenase before cell dispersion and a high concentration of methyl-alpha-mannoside wa... | 208,727 | [
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Postirradiation sarcoma (malignant fibrous histiocytoma) of axilla. | A case is reported of a patient who developed a histologically unusual sarcoma in the axilla and chest wall 8 years after receiving radiation therapy (6500 rad) for carcinoma of the breast. This sarcoma showed light- and electron-microscopic features of a malignant fibrous histiocytoma, a tumor not documented among 24 ... | 208,746 | [
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Malignant mixed tumor of the vagina probably arising in mesonephric rests. | An exceedingly rare tumor arising in the upper lateral vagina is described histologically, histochemically, and ultrastructurally. It is compared to the lesion reported by Okagaki et al. which is considered to represent the same type of tumor. Comparison with synovial sarcomas indicates that the lesion is similar, but ... | 208,750 | [
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Chemoimmunotherapy of small cell bronchogenic carcinoma. | Thirty-one patients with small cell bronchogenic carcinoma were treated with a regimen of cyclophosphamide, Adriamycin and vincristine. Radiotherapy was given to patients with limited disease. Nonspecific immunotherapy consisting of BCG scarification was administered after each chemotherapy course. The results of treat... | 208,755 | [
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Interchangeable copper and iron proteins in algal photosynthesis. Studies on plastocyanin and cytochrome c-552 in Chlamydomonas. | The interrelation of the copper protein plastocyanin, and a soluble c-type cytochrome, c-552, in photosynthetic electron transport has been studied in the genus Chlamydomonas. With C. reinhardtii the plastocyanin: cytochrome c-552 ratio could be changed from 300:1 less than 1:16 simply by omitting copper from the mediu... | 208,838 | [
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Occurrence of two fucosyltransferase activities at the outer surface of rat lymphocytes. | To demonstrate the existence of ectofucosyltransferase activities on the outer surface of rat lymphocytes, we measured fucosyltransferase activities on whole cells using procedures enabling us to exclude the possibility of misleading results due to precursor hydrolysis and intracellular utilization of the free fucose, ... | 208,846 | [
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Protein kinases of rat liver endoplasmic reticulum. Solubilisation, partial characterisation and comparison with protein kinases of rat liver cytosol. | Protein kinase associated with rat liver microsomes was only partly extracted by treatment with 1.5 M KCl. The enzyme was solubilised by Triton X-100 or sodium deoxycholate at the same or slightly higher detergent concentrations than microsomal marker components. The enzyme activity increased 2-3 fold upon solubilisati... | 208,848 | [
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Glycogen metabolism in the placenta of streptozotocin diabetic rats. | Administration of STZ prior to mating, induced significant impairment in glycogen metabolism in term rat placentae. Glycogen retention was observed in the treated placentae, while glycogen synthetase activity was reduced. The glycogenolytic pathway seemed to proceed mainly through amyloglucosidase enzyme whose activity... | 208,939 | [
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The effect of cyclic nucleotides on the incorporation of 3H-glucosamine into hyaluronate in bone organ culture. | Addition of dibutyryl cyclic AMP or parathyroid hormone to bone organ cultures markedly increased the incorporation of 3H-glucosamine into non-dialyzable macromolecules. Other cyclic nucleotides or their dibutyryl derivatives did not stimulate glucosamine incorporation. DEAE-cellulose chromatography of the papain-diges... | 208,944 | [
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Comparative studies in two cases of testicular feminization syndrome, one with and the other without the fluorescent distal band q12 of the Y. | In two patients with testicular feminization syndrome, one Yq12-positive and the other Yq12-negative, we compared phenotype, gonadal histology and ultrastructure, in vivo steroid response of the testes to the administration of exogenous gonadotropin during adrenal suppression, and of the adrenal gland to ACTH. The assu... | 208,959 | [
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Effect of Mycobacterium tuberculosis BCG infection on the resistance of mice to ectromelia virus infection: participation of interferon in enhanced resistance. | Mice infected with Mycobacterium tuberculosis BCG were more resistant than normal mice to ectromelia virus infection. It is suggested that enhanced interferon production in peritoneal exudate cells and spleen cells of BCG-infected mice plays an important role in this resistance. | 208,973 | [
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Proliferative and interferon responses by peripheral blood mononuclear cells after bone marrow transplantation in humans. | The capacity of peripheral blood mononuclear cells from bone marrow transplant recipients to proliferate and produce interferon in response to mitogens and specific antigens was tested. Proliferation in response to phytohemagglutinin or pokeweed mitogen occurred in cells from more than 90% of the recipients, and interf... | 208,979 | [
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The specificity of neutralizing antibodies to feline leukaemia viruses. | Feline leukaemia viruses (FeLV) of subgroups A (FeLV-A), B(FeLV-B) and C(FeLV-C) were examined by neutralization. The FeLV-A isolates were monotypic. By contrast, there was antigenic variation within subgroups B and C. There was also considerable cross-reactivity between subgroups. Thus, FeLV-A viruses showed weak cros... | 208,991 | [
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Studies on the retina and the pigment epithelium in hereditary canine ceroid lipofuscinosis. II. The subcellular distribution of lysosomal hydrolases and other enzymes. | Observations on the progressive course of retinal degeneration in canine ceroid lipofuscinosis (CCL) showed dramatic changes in enzyme activity and subcellular compartmentation. Thus, in affected animals, a new particle containing high levels of hexosaminidase and galactosidase was found in fractions lighter than seen ... | 208,995 | [
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Isobaric inert gas supersaturation: observations, theory, and predictions. | An isobaric inert gas supersaturation model incorporating both diffusion and perfusion properties of biological tissue is presented in a form which allows ready comparison with experimental observations. This model requires only measurement of inert gas flux and blood gas solubility in order to evaluate "counterdiffusi... | 209,005 | [
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Altered metabolism of heparan sulfate in simian virus 40 transformed cloned mouse cells. | Glycoconjugates have been analyzed from a family of closely related mouse cells: a parent clone and three daughter subclones, two of which expressed the simian virus 40 (SV40) T-antigen. The experimental procedure involved the simultaneous comparison by DEAE-cellulose chromatography of papain-digested macromolecules fr... | 209,027 | [
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Bone marrow-derived lymphoid cell lines from patients with agammaglobulinemia. | In vitro infection with Epstein-Barr virus of bone marrow-derived (B) lymphocytes from blood of patients with X-linked or common varied agammaglobulinemia resulted in the establishment of long-term B-lymphoid cell lines (LCL). LCL were established only with B lymphocytes from patients whose B cells failed to respond to... | 209,061 | [
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Relationship between the tissue level of cyclic AMP and the fat cell size of human adipose tissue. | The relationship between mean fat cell size, maximal tissue cyclic AMP concentration, and glycerol release was investigated in human subcutaneous adipose tissue incubated in vitro with or without isoprenaline or noradrenaline added at maximal effective concentrations. Basal and stimulated glycerol release and cyclic AM... | 209,114 | [
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A comparison of two methods to investigate the metabolism of human apolipoproteins A-I and and A-II. | Two methods are compared for measuring the kinetic parameters of apolipoprotein A-I and A-II metabolism in human plasma. In the first, high density lipoprotein apoproteins were radioiodinated in situ in the lipoprotein particle (endogenous apoprotein labeling) while in the second, individually labeled apolipoprotein A-... | 209,117 | [
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Studies on carbamoylphosphate synthetase in livers of rats fed a protein free diet supplemented with methionine and threonine and injected with N-acetylglutamic acid. | Supplementation of methionine and threonine to a protein free diet reduces urinary nitrogen excretion in rats, and it has been assumed that N-acetylglutamic acid may have a regulatory role in urea synthesis. The present paper reports the effect of supplementation of methionine and threonine on the levels of N-acetylglu... | 209,156 | [
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Hydrogen cyanide poisoning: treatment with cobalt EDTA. | Three case reports are presented of employees who suffered varying degrees of exposure to hydrogen cyanide and their subsequent clinical courses following treatment with cobalt EDTA. A review of treatment modalities for CN- toxicity is given. It is concluded that, because of the degree of patient symptomatology associa... | 209,160 | [
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0.245163,
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0.3750911,
0.188916,
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0.01347078,
0.05758452,
0.07128014,
0.007165206,
0.1320304,
0.375429,
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... |
Role of the simian virus 40 gene A product in regulation of DNA synthesis in transformed cells. | Cells transformed by tsA mutants of simian virus 40 (SV40) are temperature sensitive for the maintenance of the transformed phenotype. The kinetics of induction of DNA synthesis were determined for hamster cell transformants shifted to the permissive temperature after a 48-h serum arrest at the nonpermissive temperatur... | 209,212 | [
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0... |
Human cytomegalovirus DNA. I. Molecular weight and infectivity. | Human cytomegalovirus DNA (strain AD 169) was isolated from purified virions and further purified by sucrose density gradient centrifugation. The viral DNA molecules were studied by electron microscopy and found to be linear and to have a length of 76.22 +/- 5.22 micron, corresponding to a molecular weight of 147 +/- 6... | 209,219 | [
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0.08894099,
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Responsiveness of plasma aldosterone: dependency upon basal secretory activity. | The responsiveness of plasma aldosterone levels to various stimuli was evaluated in 44 normal subjects, 17 patients with mild to moderate renal failure, 30 patients with terminal renal failure, and 13 anephric subjects. Plasma aldosterone, renin activity (PRA), cortisol, sodium, and potassium levels were measured befor... | 209,245 | [
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Nasopharyngeal angiofibroma: a twenty year study. | A control rate of approximately 80% has been obtained in 45 cases of juvenile nasopharyngeal angiofibroma treated by a single moderate dose of radiotherapy at the Princess Margaret Hospital, Toronto. The remaining patients ultimately achieved control generally after further irradiation. Immediate side-effects of the tr... | 209,265 | [
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Common antigen between coxsackievirus A 16 and enterovirus 71. | Cross immunofluorescence revealed that coxsackievirus A 16 (CA 16) shared a common antigen with enterovirus 71 (E 71). The cross reactivity of these two serotypes was also examined by complement fixation test with purified virus preparations fractionated by sucrose density gradient centrifugation and two peaks of antig... | 209,293 | [
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... |
Protective effect of an oral infection with herpes simplex virus type 1 against subsequent genital infection with herpes simplex virus type 2. | The problem of whether oral Herpes simplex virus type 1 (HSV-1) infection provides protection against subsequent genital infection by Herpes simplex virus type 2 (HSV-2) was investigated. Mice were used as models. Following conditions in man, both the oral and genital infections applied were noninjurious. Mice infected... | 209,295 | [
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... |
A possible model for the structure of the Neurospora carbamoyl phosphate synthase-aspartate carbamoyl transferase complex enzyme. | The pyrimidine-3 locus of Neurospora crassa specifies a multienzyme complex comprising pyrimidine-specific carbamoyl phosphate synthase (CPSpyr) and aspartate carbamoyl transferase (ACT). It appears to be divided into a translationally proximal CPS-specific region and a distal ACT-specific region. Levels of complementa... | 209,307 | [
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Cyclic AMP increase the Na+ permeability of the avian erythrocyte membrane by a process which does not involve protein phosphorylation. | Preparations of avian erythrocyte plasma membranes have been made which are in the form of sealed vesicles. Using these preparations the permeability of the membranes to N+, K+, Mg2+ and Ca2+ was measured. Monobutyryl cyclic AMP and cyclic AMP increased the permeability to Na+ and Ca+ under conditions where no protein ... | 209,312 | [
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Further evidence for a change in central alpha-adrenergic receptor sensitivity after withdrawal from long-term haloperidol treatment. | Phenoxybenzamine, FLA-63 and alpha-MT produced less locomotor depression in mice withdrawn for 4 days from a 21 day treatment with haloperidol than that produced in vehicle-treated animals. There were no differences between the two groups when challenged with yohimbine or phentolamine. The data support the hypothesis t... | 209,350 | [
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[Expression of paternal genes controlling cytochrome oxidase activity in hybrid fish]. | The heat resistance of the oxygen consumption by the mitochondria, temperature dependence of the Michaelis' constant (CM) and heat resistance of cytochrome oxidase were studied in the embryos and larvae of fish hybrids (Misgurnus X Brachydanio). The oxygen consumption by the mitochondria from the larvae of Misgurnus ce... | 209,380 | [
0.1792563,
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0.2083742,
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0.2490934,
0.6663622,
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... |
[Epidemiology of primary bronchus cancer from which the African Negro suffers (author's transl)]. | The study of 86 cases collected along 5 years regarding the primary bronchus cancer from which the African Negro in Abidjan suffers, points out the recent increase of this pathology, the predominating epidermolid histological type, the fact that men reaching a critical age of 45 years old are mostly concerned and espec... | 209,403 | [
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0.4413177,
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0.3440803,
0.4721493,
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0.... |
Effect of dietary aflatoxin on vitamin D3 metabolism in chicks. | Male broiler chicks were fed diets containing either O (control) or 2.5 p.p.m. aflatoxin (toxin) for four weeks. A group of eight birds fed each diet was infected intravenously with radioactive vitamin D3 (D3) and a second group with radioactive 25-hydroxy vitamin D3 (25-OH D3). Plasma was obtained 24 hr. after dosing ... | 209,429 | [
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0.3971212,
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0.... |
Differentiation of progressive versus regressive Rous virus-induced avian sarcomas according to tumor and infiltrating lymphocyte fine structure. | Electron microscope examination of progressing and regressing Rous virus-induced sarcomas in an inbred line of White Leghorns revealed that regressing tumors contained moderate to marked lymphocyte infiltration, frequent contact between lymphocytes and tumor cells, and extensive areas of necrosis. Lymphocytes infiltrat... | 209,431 | [
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0.4269869,
0.3465228,
0.3670226,
0.1763456,
-0.238535... |
Lymphocytotoxicity of chickens bearing Rous sarcomas. | A 51Cr uptake microcytotoxicity assay was used to determine the cytotoxicity of lymphocytes from chickens bearing Rous sarcomas. Differences in lymphocyte cytotoxicity among individual chickens were statistically significant. Lymphocytes from chickens regressing (or having regressed) their tumors were significantly mor... | 209,432 | [
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0.134404,
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[Separation and purification of isoenzymes of Clostridium perfringens phospholipase C]. | The procedure for separation and purification of isoenzymes of phospholipase C from Clostridium perfringens (PLC) was developed. The procedure included primary concentration of culture liquid proteins and isoenzyme separtion on DEAE-cellulose during negative sorption of the major isoenzyme. Further purification of the ... | 209,439 | [
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0.2774485,
0.4734169,
0.1712805,
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0.2... |
[Relationship between the hypophyseal-adrenal and the genital systems in silver-black foxes]. | Interaction between the hypophysial-adrenal system (HAS) and the hypophysis-gonad system was studied. For this purpose the foxes were subjected to total gonadectomy 8 months before they were sacrificed. Functional activity of the HAS was judged by the hypophysis ACTH content, corticosteroid production by the adrenal co... | 209,441 | [
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0.09312191,
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... |
Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization. | Rat hepatoma cells infected with mouse mammary tumor virus contain multiple forms of unintegrated viral DNA when grown in the presence of glucocorticoids. Using the DNA transfer procedure of Southern, we have prepared restriction endonuclease fragment maps of these forms of viral DNA. The maps indicate that: (i) the ma... | 209,450 | [
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0.0... |
Adenosine 5'-O-([gamma-18O]gamma-thio)triphosphate chiral at the gamma-phosphorus: stereochemical consequences of reactions catalyzed by pyruvate kinase, glycerol kinase, and hexokinase. | The 2-[18O]phosphorothioate of D-glycerate, chiral at phosphorus, was prepared. The chiral phosphoryl group was transferred enzymically to ADP [by using enolase and pyruvate kinase (ATP:pyruvate 2-O-phosphotransferase; EC 2.7.1.40)] resulting in the synthesis of adenosine 5'-O-([gamma-18O],gamma-thio)triphosphate. This... | 209,459 | [
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0.2581892,
0.3348196,
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Barbiturate dependence in mice: evidence for beta-adrenergic receptor proliferation in brain. | C57BL/6J and DBA/2J inbred mice were assayed for beta-adrenergic receptor density following seven days of chronic phenobarbital intoxication. These physically dependent mice showed a greater brain receptor density than did the control, while acute intoxication to phenobarbital produced no significant effects. C57BL/6J ... | 209,505 | [
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Studies on bovine leucosis V. A comparative study on the practical value of the agar gel immunodiffusion test, the indirect fluorescent antibody technique and the micro complement fixation test for the detection of antibodies to bovine leucosis virus. | The practical value of the indirect fluorescent antibody technique (I FAT), the micro complement fixation test (M CFT) and the agar gel immunodiffusion test (AGIDT) for the detection of antibodies to bovine leucosis virus (BLV) was investigated. For this purpose 1495 serum samples were examined. There was a remarkably ... | 209,575 | [
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0.1900591,
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0.06133661,
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Hypercalciuria related to cadmium exposure. | A work force has been investigated for possible cadmium intoxication. One group who are coppersmiths have an 18.5 per cent prevalence of upper urinary tract stone disease associated with a statistically highly significant hypercalciuria and reduced serum inorganic phosphate. Proof of exposure to cadmium has been confir... | 209,595 | [
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0.01522009,
0.1559145,
0.1803661,
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... |
Spheroidal filamentous inclusion body cells in von Recklinghausen's disease. | Cells with spheroidal filamentous cytoplasmic bodies, distinctive by both light and electron microscopy, were found in a neoplasm arising from the sciatic nerve of a patient with von Recklinghausen's disease. Tissue fixed with formalin and embedded in paraffin for three years was deparaffinized, reprocessed, and examin... | 209,609 | [
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0.002651879,
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0.06497883,
0.003489171,
0.236414,
0.06452... |
Tumour cell interactions in vitro. Evidence for the occurrence of tumour cells within other tumour cells. | After addition of dibutyryl cAMP to spinner flask cultures of JB-1-E tumour cells an increase in the number of examples of emperipolesis was observed. Ruthenium red staining of the cells revealed a conspicuous staining of the cell membrane of the outer cell, while that of the inner cell was unstained. The differences i... | 209,612 | [
-0.2567563,
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0.7764212,
0.08590852,
0.00118... |
Investigations on the presence of antibodies to alphaviruses, flaviviruses, Bunyavirus and Kemerovo virus in humans and some domestic animals. | The presence of antibodies to some alphaviruses, flaviviruses, bunyaviruses and orbiviruses was studied in the sera from humans and domestic animals of biotopes "C" and "T" in the south-east of Romania. Specific antibodies were found in humans to 3 alphaviruses (eastern equine encephalitis, western equine encephalitis ... | 209,613 | [
0.05234822,
0.1562217,
0.05244933,
0.1071655,
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0.279901,
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0.2268292,
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0... |
[Angiography in abdominal diseases (author's transl)]. | Angiography of arteries and veins in the abdominal and retroperitoneal compartement is a valuable routine roentgenologic procedure. Its value in the diagnosis of vascular disorders is apparent. Regarding space occupying lesions in the abdomen angiography is an aid in diagnosis and differential diagnosis and provides in... | 209,634 | [
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0.008122943,
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0.04748503,
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0.1978716,
0.07499962,
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0.2587254,
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0.0... |
Plasma lipids and lipoproteins in young patients with brain infarction. | Thirty-two patients aged 60 or less with brain infarction were examined with regard to possible changes in lipoprotein pattern as compared with a reference group. Except for a lower concentration of total lipids, cholesterol and high-density lipoproteins in the female patients, no difference was demonstrated in the two... | 209,655 | [
-0.09734522,
0.3397787,
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0.07594775,
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0.3495538,
0.1430135,
0.09878224,
-0.06316... |
Early diagnosis of cancer by gastricbiopsy. | On the basis of 350 gastric biopsies the difficulties of early diagnosis of cancer are discussed. The technical and morphological stumbling blocks of evaluation are reviewed. The differences between the gross and microscopic diagnoses, the more important causes of histologic error are dealt with. | 209,670 | [
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0.3751897,
0.1987387,
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... |
Lisfranc's fracture-dislocation: a manifestation of peripheral neuropathy. | Lisfranc's fracture-dislocation may be secondary to acute trauma, but on the basis of our experience with seven cases, it is more commonly a manifestation of repetitive subclinical trauma in patients with a neuropathic disorder. Separation of these two groups of patients is important, since those with acute trauma requ... | 209,679 | [
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Fine needle aspiration biopsy in the diagnosis of mediastinal lesions. | In the presence of a mediastinal mass, fine needle aspiration biopsy is an alternative to other time-consuming and expensive diagnostic procedures. We have performed a total of 25 fine needle aspiration biopsies of mediastinal lesions in 18 patients. Although our material is too limited to reach definite conclusions as... | 209,680 | [
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0.03862369,
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Aniridia, cataracts, and Wilms' tumor in monozygous twins. | We studied the first instance of aniridia-Wilms' tumor syndrome in twins who were mentally retarded. Both of them had congenital aniridia, cataracts, and glaucoma; only one subsequently developed a Wilms' tumor. A two-allele, two-step mutation is the most likely explanation of this genetically abnormal syndrome in twin... | 209,691 | [
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... |
Peptides and psychoneuroendocrinology. A perspective. | Research indicates that brain peptides exert both behavioral and endocrinologic effects in humans and animals. This review summarizes the best known behavioral actions of four endogenous peptides: luteinizing hormone-releasing hormone (LHRH), adrenocorticotrophic hormone (ACTH), vasopressin, and angiotensin. The hypoth... | 209,758 | [
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GABA in pancreatic islets. | A high concentration of gamma-aminobutyric acid (GABA) and a high activity of glutamate decarboxylase (GAD), enzyme for GABA synthesis, were demonstrated in the rat pancreatic islets using a recently developed assay method combining the GABase system with the enzymatic NADP-NADPH cyclin method. Both GABA concentration ... | 209,763 | [
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0.13... |
Synovial sarcoma of the neck associated with previous head and neck radiation therapy. | Synovial sarcoma is a rare neoplasm that uncommonly arises in the neck. Fourteen years after facial and neck radiation therapy for acne, synovial sarcoma of the neck developed in a young man. Possible radiation-induced benign and malignant neoplasms that arise in the head and neck region, either of thyroid or extrathyr... | 209,774 | [
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... |
Lipoprotein composition in diabetes mellitus. | Lipoprotein cholesterol and triglyceride levels have been determined in normal and diabetic Pima Indian women aged 20-35, HDL cholesterol levels were lower, LDL cholesterol levels were higher, and the ratio of HDL cholesterol/LDL cholesterol, a reflection of lipoprotein cholesterol distribution, was lower in the diabet... | 209,799 | [
0.2250594,
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Effect of specific lysine modification on the reduction of cytochrome c by succinate-cytochrome c reductase. | The reduction of cytochrome c by succinate-cytochrome c reductase was studied at very low cytochrome c concentrations where the reaction between cytochrome c1 and cytochrome c was rate limiting. The rate constant for the reaction was found to be independent of ionic strength up to 0.1 M chloride, and to decrease rapidl... | 209,818 | [
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[Binding of spin-labeled palmitic acid by bovine serum albumin]. | Investigation of the binding of spin-labeled palmitic acid and its esters with bovine serum albumin is presented. Both probes are shown to bind strictly to strongly and loosely binding centers of protein. The quantitative study allows to determine the binding constant and number of protein binding sites. It is found th... | 209,828 | [
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... |
Binding assay for opioid peptides with neuroblastoma x glioma hybrid cells: specificity of the receptor site. | A sensitive and rapid radioreceptor assay has been developed to monitor opioid peptides in column effluents. It is based on competitive binding to NG 108-15 cells using [3H-Tyr]Leu-enkephalin as the displaced ligand. The specificity of binding to the cells of naturally occurring opioid peptides and synthetic analogs ha... | 209,856 | [
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Combination modality therapy in lung cancer: a survival study showing beneficial results of AMCOF (adriamycin, methotrexate, cyclophosphamide, oncovin and 5-fluorouracil). | Thirty-seven patients with advanced or recurrent lung cancer were randomized to cytoxan (CTX) alone, COMF (CTX, oncovin, methotrecate and 5-FU) or AMCOF (adriamycin, methotrexate, CTX, oncovin and 5-FU) after receiving radiation therapy to primary and bulky tumor sites. Median survival was 3 months for CTX, 6 months fo... | 209,881 | [
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Effect of submaximal isometric exercise on catecholamine, cAMP and lactate concentrations in the coronary circulation of man, following atropine and oxprenolol. | The effects of atropine and oxprenolol on changes occurring in total catecholamine, cyclic AMP (cAMP) and lactate concentrations in arterial and coronary sinus blood, during submaximal isometric exercise, were studied in 10 patients. Static one-third-maximal handgrip exercise, sustained for 5 minutes, did not produce a... | 209,899 | [
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0.04387374,
... |
In vitro studies of the interaction of isolated Lp(a) lipoprotein and other serum lipoproteins with glycosaminoglycans. | The interaction of isolated Lp(a) lipoprotein or other lipoprotein classes with different glycosaminoglycans (GAG) bound to activated Sepharose was studied. In contrast to LDL, the Lp(a) lipoprotein did not bind to the GAG tested if sodium was used as a buffer cation. In the presence of Ca++, however, even the Lp(a) li... | 209,919 | [
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... |
Effects of PBB on cattle. II. Gross pathology and histopathology. | Toxicosis was induced in pregnant Holstein heifers by feeding FireMaster BP-6 (polybrominated biphenyls) in daily oral doses of 25 g/head/day for 33--60 days. The individual heifers were dosed until each became moribund (days 33, 36, 39, 40, 41, or 66), at which time they were necropsied. Gross findings included dehydr... | 209,962 | [
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... |
Toxicity of PBBs with special reference to porphyrinogenic action and spectral interaction with hepatic cytochrome P-450. | Some of the polyhalogenated aromatic compounds (PHAs) which are able to produce porphyria are presently known as environmental contaminants. Chronic exposure to PHAs causes hepatic porphyria in different species. Qualitatively PBBs act comparable to PHAs. An increase in accumulation of porphyrins caused by PHAs is not ... | 209,971 | [
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0.... |
Relation of DDE and PBB serum levels in farm residents, consumers, and Michigan Chemical Corporation employees. | Results of serum PBB determinations on 524 Michigan diary farm residents and consumers of products from the farms, 55 chemical workers, and 56 Wisconsin farm residents are reported. Mean and median values were highest for the chemical workers, followed by consumers from and residents of quarantined and nonquarantined f... | 209,972 | [
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... |
Polybrominated biphenyl toxicosis in rats fed an iodine-deficient, iodine-adequate, or iodine-excess diet. | Young male Sprague-Dawley rats were fed 0, 1, 10, or 100 ppm of polybrominated biphenyls (PBB) in iodine-deficient, iodine-adequate (0.2 ppm), or iodine-excess (1000 ppm) diets. Six rats in each of the 12 groups were killed at 30 days and the remaining six in each group at 60 days. Growth rates were similar in all rats... | 209,997 | [
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0.1127954,
... |
Assessment of the hazards of polybrominated biphenyls. | During their peak use period, PBBs represented under 1% of the total sales of fire retardant chemicals, and very probably would have escaped intensive study if they had not been mixed accidentally with animal feed preparations. Instead, international attention was drawn to PBBs by the state-supervised killing of over 3... | 209,999 | [
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Topographical studies on histamine- and adrenaline-sensitive adenylate cyclases in gastric and duodenal mucosa of human beings. | The distribution of histamine- and catecholamine-sensitive adenylate cyclases in human gastric and duodenal mucosa was studied. Basal enzyme activities averaged 155 pmol cAMP/mg prot./15 min in fundic gastric mucosa, 305 pmol cAMP/mg prot./15 min in the antral and 344 pmol cAMP/mg prot./15 min duodenal mucosa. 1 mM his... | 210,068 | [
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0.... |
Endotoxin and the liver. III. Modification of acute carbon tetrachloride injury by polymyxin b--an antiendotoxin. | Previous work suggests that endotoxin of enteric origin may contribute to both acute and chronic liver injury by other agents. In particular, evidence exists that endotoxin tolerance modifies biochemical and histological evidence of carbon tetrachloride hepatotoxicity. The present study was undertaken to ascertain whet... | 210,083 | [
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Monophasic synovial sarcoma--a histological entity? | Consideration is given to the concept of a histologically identifiable monophasic type of synovial sarcoma. It is accepted that a sarcomatous tumour may be encountered where the spindle cells assume a somewhat epithelioid appearance associated with a reticulin pattern unlike that of most other spindle cell sarcomas. Th... | 210,101 | [
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... |
Seroepidemiologic aspects of varicella zoster virus infections in an Israeli Jewish population. | Sera from 872 healthy subjects among the Jewish population of Israel were examined for antibodies to varicella zoster virus (VZV) by a simplified technique for the detection of immunofluorescent antibody to membrane antigen. The difference in the geometric mean titer of antibodies to the virus among the the different a... | 210,147 | [
0.006752864,
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0.4555549,
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Chemical and electrophoretic changes induced by polymyxin B on outer membrane components from Serratia marcescens. | The effects of polymyxin B (PB) on outer membrane (OM) components from resistant (strain 08) and sensitive (strain Bizio) cells of Serratia marcescens were characterized by chemical analysis and polyacrylamide gel electrophoresis (PGE) in sodium dodecylsulfate. Chemical analysis revealed no major differences in the OM ... | 210,151 | [
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0.2510173,
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Hepatic alpha-adrenergic receptors. Identification and subcellular localization using [3H]dihydroergocryptine. | Recently, several workers have shown that adrenergic control of hepatic carbohydrate metabolism has the characteristics of an alpha-receptor-mediated process. Using the rat liver membrane preparation of Neville (Neville, D. (1968) Biochim. Biophys. Acta 154, 540-552), alpha-adrenergic receptors have been identified usi... | 210,164 | [
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... |
Adenosine 3':5'-monophosphate receptor proteins in mammalian brain. | cAMP receptor proteins present in mammalian brain were identified and characterized with the use of the photoaffinity label 8-azido[32P]cAMP. Cytosol and membrane fractions from various regions of rat, guinea pig, and bovine brain contained two specific cAMP receptor proteins with apparent molecular weights of 47,000 a... | 210,173 | [
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0.5024861,
0.1964679,
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An ultrastructural study of the formation of "dark" and "light" cytoplasmic inclusions by murine cytomegalovirus in mouse submandibular gland. | Electron micrographs of acinar cells of the submandibular glands of CFW mice infected with murine cytomegalovirus, Smith strain, were studied. The resulting viral intracytoplasmic inclusion bodies were classified into two groups termed "light" (relatively electron-lucent) and "dark" (relatively electron-dense). It appe... | 210,198 | [
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0.3321812,
0.09713537,
0.03903301,
0.06776999,
-0.016650... |
Inactivation of cytomegalovirus and Semliki Forest virus by butylated hydroxytoluene. | Butylated hydroxytoluene (BHT) is an antioxidant that is widely used in foods because it prevents spoilage by delaying degradation of lipid components. This hydrophobic compound inactivated human and murine cytomegalovirus (CMV) and Semliki Forest virus (SFV). Both human and murine CMV were inactivated more than 90% by... | 210,237 | [
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-0.1470295,
-0... |
Cytomegalovirus infection in guinea pigs. II. Transplacental and horizontal transmission. | Transplacental transmission of cytomegalovirus (CMV) was demonstrated in guinea pigs, but transmission only occurred during acute primary maternal infection. Infectious CMV was isolated from 27 of 44 placental tissues and nine of 37 fetal tissues (including brain, lung, and kidney) tested five to 24 days after maternal... | 210,239 | [
-0.1076611,
-0.07325877,
-0.1818708,
0.00766051,
0.1114669,
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0.1452488,
0.2264217,
0.01976653,
0.1445499,
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0.02669655,
0.1910574,
0.1692908,
0.1060327,
0.2563633,
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... |
Brain reaggregate cultures: biochemical evidence for myelin membrane synthesis. | Myelin membrane synthesis was studied using mechanically dissociated fetal rodent CNS which formed spherical reaggregates while being maintained in rotating culture flasks. These reaggregate cultures exhibited myelinogenesis in vitro after precisely the same period of time needed for myelin synthesis to commence in viv... | 210,255 | [
0.09289496,
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0.1209713,
0.01131105,
0.1094068,
0.199227,
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0.2780562,
0.176206,
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... |
REM motivation induced by brief REM deprivation: the influence of cognition, gender, and personality. | Prominence of the brain's right-hemisphere information processing and intensity of dream experience are two theoretically related constructs that have been proposed as important psychological aspects of REM sleep. Either view is consistent with the prediction that the effect of REM deprivation will depend in part on th... | 210,272 | [
-0.1880004,
0.4113618,
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0.2016847,
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0.1390919,
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0.1581372,
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0.07417686,
0.1379427,
0.02181104,... |
The mechanism of chlorothiazide-induced carbohydrate intolerance. | In order to establish the mechanism(s) of chlorothiazide-induced hyperglycemia, measurements of blood glucose, plasma insulin, liver glycogen and hepatic cyclic adenosine 3':5'-monophosphate (cyclic AMP) levels, and liver phosphodiesterase activity were made in rats administered 10, 25, 50 or 100 mg/kg of the drug. Com... | 210,275 | [
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0.2639786,
0.1609249,
0.3020402,
0.125521,
-0... |
Neuraminidase production by clostridia. | The production of neuraminidase (EC 3.2.1.18) by a range of clostridial species was investigated with techniques previously developed to distinguish neuraminidase-negative and neuraminidase-positive strains of Clostridium perfringens (welchii). Large amounts of extracellular neuraminidase were produced by representativ... | 210,277 | [
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0.5883626,
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Suppressed murine mammary tumor virus (MuMTV) expression in RIII female mice treated neonatally with goat antiserum to MuMTV. | Passive immunization of newborn inbred RIII (R3) mice with the globulin fraction of goat antiserum to murine mammary tumor virus (MuMTV) successfully suppressed MuMTV expression in the milk of some of the treated mice throughout nine successive lactations. No mammary tumors developed in the MuMTV-suppressed mice during... | 210,290 | [
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0.1113026,
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0.3391111,
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Toward less hazardous cigarettes. Current advances. | Critical levels of selected cigarette smoke constituents have been expressed in terms of maximum numbers of pre-1960 cigarettes that a smoker may consume daily without increasing his mortality risk substantially above that of a nonsmoker. This could still imply an important risk, although it may be difficult to detect.... | 210,299 | [
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0.1155542,
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0.100349,
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0.01599651,
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0.1983032,
0.4259585,
0.1737995,
0.2061384,
0.303905,
-0.05371037,
-0.0... |
Transfusion-related short-incubation hepatitis in hemophilic patients. | Nine episodes of a unique short-incubation form of hepatitis were observed during five years in six hemophilic children after infusion with commercial factor VIII concentrate prepared by two different manufacturers. Five patients with a single episode had no previous infusion for 14 months to 14 years. One patient with... | 210,302 | [
-0.5492437,
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0.02559011,
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0.05497582,
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0.1374692,
0.3673629,
0.1831914,
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... |
Congenital mesoblastic nephroma and polyhydramnios. | Polyhydramnios and premature delivery complicated the pregnancies of three women whose infants were born with renal tumors. In each case the tumor was a mesoblastic nephroma. The liquid of polyhydramnios enhances detection of masses in the fetal abdomen by ultrasound. In the future, mesoblastic nephroma may, therefore,... | 210,304 | [
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0.09259354,
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0.1284924,
0.07162313,
-0.4090597,
0.5600136,
0.1765979,
-0.266103,
-0... |
Isolation of mouse hepatitis virus from infant mice with fatal diarrhea. | An epizootic of fatal diarrhea occurred in mice which were approximately 10 days of age. The enteric lesions were similar to those reported in lethal intestinal virus of infant mice, but many diseased mice also had necrotic hepatitis. Mouse hepatitis virus antigen was demonstrated in the affected intestine and liver, a... | 210,327 | [
-0.4346624,
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0.05422284,
0.2488764,
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0.00961074,
0.001709996,
0.001803226,
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-0.08103105,
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0.06949402,
0.1559287,
0.1814524,
-0.1064608,
0.1941701,
-0.07... |
Cardiac paraganglioma (chemodectoma): a case report and review of the literature. | A rare case of paraganglioma (chemodectoma) of the heart is reported. This is the fifth case reported in the world literature and only the second case discovered in a living person. A review of the historical background, embryology, anatomy, and pathology of the paraganglia is provided. The previously reported four cas... | 210,330 | [
-0.4040239,
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0.03740976,
0.1641234,
0.409281,
0.4467943,
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0.2794448,
0.00000518141,
0.04934675,
-0.07241787,
0.4772172,
-0.1849... |
Location of the cleavage sites on the SV 40 DNA map produced by the restriction endonucleases Pst 1 and Bam 1. | Restriction endonucleases from Providencia stuartii (Pst 1) and Bacillus amyloliquefaciens H (Bam 1) cleave SV 40 DNA at two and one specific sites, respectively. Using EcoRI and Hind III endonuclease restriction sites as reference, the two Pst I sites were mapped at 0.050; 0.265 and the Bam I site was mapped at 0.170 ... | 210,371 | [
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0.1336323,
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0.1344386,
0.377633,
0.2091306,
0.1231273,
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0.5428653,
0.4443257,
-0.1400314,
0.3275122,
0.1984341,
-0.07984629,
-0... |
High affinity of carozolol for beta-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and Xenopus laevis. | Catecholamine-induced stimulation of adenylyl cyclase in ventricular membranes of kitten and Xenopus laevis was antagonized competitively by carazolol. Apparent equilibrium constants ranging between 100-170 pM were estimated for the beta-adrenoceptor-carazolol complex. | 210,404 | [
0.1375861,
0.1792952,
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0.219801,
0.02071003,
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0.2025201,
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0.2521054,
0.3926092,
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0.07832884,
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0.1900323,
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0.1628079,
0.5441815,
0.06608493,
-0.0604958,
0.... |
Effect of parathyroid hormone and insulin on extracellular cyclic adenosine-3',5'-monophosphate in patients with benign and malignant breast tumors. | Basal excretion of cyclic adenosine monophosphate (cAMP) and its basal level in blood plasma in breast cancer (BC) patients and those with fibroadenomatosis did not differ essentially. However, intravenous injection of parathyroid hormone (100 U) and insulin (0.08 U/kg body weight) was followed by a much less rise in u... | 210,408 | [
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0.2100145,
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0.2362952,
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0.4566516,
0.08809292,
0.2523766,
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0.07861694,
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-0.1703202,
-0.001408136,
0.1666241,
0.0184507,
0.4107989,
0.1677031,
-0.2574158,
0.0... |
[Role of hormonal receptors in the regulation of the corpus luteum (author's transl)]. | Recent publications dealing with the hormonal regulation of the corpus luteum function have been reviewed. Hormones involved in this regulation are: LH and placental analogue hCG, FSH, prolactin and placental analogue hPL, prostaglandins, oestradiol and androgens. The hormone receptor interaction in the luteal cells an... | 210,437 | [
0.1459794,
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0.2803777,
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-0.04743275,
-0.1713428,
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0.108494,
0.07269211,
0.2153268,
0.004785822,
0.1892811,
-0.06430656,
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-0.6184025,
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-0.03117,
0.005492603,
0.233322,
0.336932,
0.1127538,
-0.1748035,
-... |
Paradoxical effects in sleep and performance of two doses of chlorpromazine. | Twenty-four subjects were given placebo, 25 mg, and 75 mg of chlorpromazine on three separate occasions. Twelve subjects were treated in the morning and tested for performance during the day. Twelve other subjects received the drug treatments in the evening. Both groups had their EEG stages of sleep recorded during the... | 210,476 | [
-0.2471642,
0.1839843,
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0.3416245,
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-0.2801493,
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0.02113527,
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0.3005997,
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0.2593094,
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-0.5394444,
0.2843696,
-0.1895747,
0.04914468,
-0.004612453,
0.3523523,
0.2613168,
... |
[Insulinoma in the computer-tomogramm (author's transl)]. | Documentation of insulinoma by computerized tomography and the diagnostic value of this new method compared with conventional radiography is discussed. The study of four cases demonstrates the capability of computer tomography to localize tumors in the pancreas. | 210,481 | [
-0.04894028,
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0.2000232,
0.2795203,
0.1189201,
0.1893563,
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0.02250933,... |
[The state of hormone and chemotherapy in breast neoplasms]. | Several decisive developments have emerged during the past few years in the hormonal treatment and chemotherapy receptors should make for a more selective and successful application of hormone therapy. In the field of chemotherapy, highly active substances have been developed. Two groups of routine treatment may be def... | 210,499 | [
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0.00473873,
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0.2791132,
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0.2296959,
0.0778675,
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0.1378327,
0.1818067,
0.2434553,
0.5683763,
0.7220846,
0.007230319,
-0.09746151,
0.... |
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