title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Synergistic lysis of erythrocytes by Propionibacterium acnes. | Sheep and human erythrocytes, partially processed by Staphylococcus aureus or Clostridium perfringens, were susceptible to lysis in the presence of Propionibacterium acnes. P. acnes liberated a lipase that was detected on Tween 80 agar and also on phospholipase C-precipitated egg yolk agar. Such a lipase might have con... | 212,450 | [
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The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. | The pathogenicity for mice of two mutants of herpes simplex virus (type 1 and type 2), which fail to induce thymidine kinase, were compared with their respective parent strains. The mutants were much less virulent than the parents following either intracerebral or peripheral inoculation. The replication of the virus at... | 212,476 | [
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Localization of hepatitis A antigen in marmoset organs during acute infection with hepatitis A virus. | Twelve marmosets (Saguinus mystax) were inoculated intravenously (iv) with hepatitis A virus (HAV). One died early (day 12); seven were sacrificed at the time of elevation in level of alanine aminotransferase (serum glutamic-pyruvic transaminase), and four without elevation were not sacrificed but seroconverted. In the... | 212,488 | [
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Helper-independent mink cell focus-inducing strains of Friend murine type-C virus: potential relationship to the origin of replication-defective spleen focus-forming virus. | Recent studies have indicated that both the replication-defective spleen focus-forming virus (SFFV) in the Friend virus complex and the helper-independent mink cell focus-inducing (MCF) viruses derived from AKR-murine leukemia virus (MuLV) are env gene recombinants between ecotropic virus and xenotropic virus. In an at... | 212,504 | [
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Suppression of interferon production in mouse spleen cells by cytochalasin D. | Cytochalasin D is thought to impair microfilament function. The present study has investigated its effects on four different systems in which interferon is formed, namely (1) mouse fibroblasts induced with virus (2) mouse spleen cells induced with virus, or (3) with endotoxin or (4) by allogeneic stimulation. Cytochala... | 212,512 | [
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Comparison of interferon action in interferon resistant and sensitive L1210 cells. | Translation inhibition, leu-tRNA aminoacylation and double-stranded RNA and ATP dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse L 1210 R and L 1210 S cells. No differences were observed between the respective interferon-treated and control cell-free extract... | 212,514 | [
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Optical diffraction analysis of electron microscope images of tubular structures found in cells infected with herpes simplex virus type 2. | Optical diffraction analysis was done on the electron micrographs of tubular structures found in cells infected with herpes simplex virus type 2. By this method, the helical arrangement of subunits forming a tubular structure was demonstrated. | 212,515 | [
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Steroid hormone alteration of herpes simplex virus type 1 replication. | The effect of steroid hormones on herpes simplex virus type 1 replication was examined. Virus replication studies revealed that various concentrations of prednisolone, hydrocortisone, dexamethasone, or progesterone could decrease virus yields up to a maximum of 99%. Using isopycnic centrifugation in CsCl to separate vi... | 212,528 | [
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Human rotavirus infection in infants and young children with intussusception. | Human rotavirus was detected by electron microscopy in 11 of 30 infants and young children with intussusception (37% of subjects under study). Serologic complement fixation tests revealed evidence of infection with the rotavirus in 70% of the patients examined who eliminated the rotavirus in their stools. These results... | 212,529 | [
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2,3-Dimercaptosuccinic acid: a new agent for the treatment of lead poisoning. | Using minimally lead-poisoned rats, we have measured urinary and fecal lead excretion in response to 2,3-dimercaptosuccinic acid (DMS) administered i.p. or p.o. and compared it to that induced by dimercaptopropanol (BAL) (i.p.), EDTA (i.p.), D-penicillamine (p.o. and i.p.) and the combination of BAL and EDTA (i.p.). At... | 212,548 | [
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Effects of adenosine triphosphate and prostaglandins on vascular adrenergic transmission. | The effects of prostaglandins (PGs) on the adrenergic neuroeffector transmission and their relationship to the action of ATP were investigated. This was in view of the putative negative feedback mediated by ATP or a related purine compound, and the reported stimulation of PG synthesis by adenine nucleotides. The centra... | 212,549 | [
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The role of calcium in the receptor mediated control of potassium permeability in the rat lacrimal gland. | 1. In the presence of extracellular Ca, adrenaline stimulated a large increase in the rate of K (86Rb) release from rat lacrimal slices, followed by a lower, more sustained rate. 2. In the absence of extracellular Ca, adrenaline elicited only a transient release of 86Rb. 3. The artificial introduction of Ca into the cy... | 212,554 | [
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A voltage-clamp study of the permeability change induced by quanta of transmitter at the mouse end-plate. | 1. Miniature end-plate currents (m.e.p.c.s) were recorded from mouse diaphragm using a point voltage-clamp. The relation between m.e.p.c. amplitude and membrane potential was determined in bathing solutions of varied composition. 2. In solution containing normal sodium the relation between m.e.p.c. height and membrane ... | 212,556 | [
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Viral gene expression in murine sarcoma virus(murine leukemia virus)-infected cells. | NIH 3T3 cells infected with Moloney murine sarcoma virus (murine leukemia virus) produce virions which contain about 99% murine sarcoma virus RNA and 1% murine leukemia virus RNA. This report describes experiments which measured intracellular concentrations of proviral DNA and RNA transcripts for each of the viruses. W... | 212,592 | [
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In vitro synthesis of double-stranded DNA from the Kilham rat virus single-stranded DNA genome. | Double-stranded, full-length linear DNA was synthesized in vitro by using single-stranded linear DNA as a self-priming template from the parvovirus Kilham rat virus and Escherichia coli DNA polymerase "large fragment" as the polymerizing enzyme. To ascertain the order of the synthesis of the cleavage fragments and to a... | 212,593 | [
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Inverted terminal repeats in rabbit poxvirus and vaccinia virus DNA. | In both rabbit poxvirus and vaccinia virus DNA have demonstrated an identical distribution of eight HinfI. The length of the terminal repeats was found to be 3.4 to 3.6 megadaltons (Mdaltons) for rabbit poxvirus DNA and 7.4 to 8.0 Mdaltons for vaccinia virus DNA. Maps of the HinfI restriction sites within isolated EcoR... | 212,601 | [
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Synthesis of T4 DNA and bacteriophage in the absence of dCMP hydroxymethylase. | Several lines of research have suggested that the dCMP hydroxymethylase (HMase) coded by bacteriophage T4 is an essential protein in a DNA replication complex, as well as a supplier of hydroxymethyl dCMP for phage DNA synthesis. We show that a mutant [HMase, dCTPase, endonuclease II, endonuclease IV] which lacked this ... | 212,605 | [
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Mechanism of transfection of chicken embryo fibroblasts by Rous sarcoma virus DNA. | The mechanism of transfection by Rous sarcoma virus DNA was investigated by assaying DNA-mediated transformation under conditions which restricted secondary virus infection. Chicken embryo fibroblasts which were genetically resistant to virus infection as a result of the absence of receptors for virus penetration were ... | 212,612 | [
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Complications of leprosy. | Leprosy is essentially a systemic disease and is a great "mimicker" of many other diseases. It affects apart from skin and peripheral nerves, haemopoietic, reticulo-endothelial and endocrine systems as well as eyes, bones and muscles. | 212,642 | [
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Subsensitivity of the rat striatal dopaminergic system after treatment with bromocriptine: effects on [3H]spiperone binding and dopamine-stimulated cyclic AMP formation. | Repeated daily administration of the dopamine (DA) agonist bromocriptine (15 mg/kg; s.cut.) to rats led to a time dependent decrease in the in vitro binding of [3H]spiperone to striatal membranes. Kinetic analysis of [3H]spiperone binding after 2 and 7 days of bromocriptine treatment showed a 25-50% reduction in the to... | 212,684 | [
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Alterations of hepatic Na+,K+-atpase and bile flow by estrogen: effects on liver surface membrane lipid structure and function. | Administration of the synthetic estrogen ethinyl estradiol (17alpha-ethinyl-1,3,5-estratriene-3,17beta-diol) decreases hepatic Na(+),K(+)-ATPase (ATP phosphohydrolase; EC 3.6.1.3) activity and bile flow to 50% and alters the composition and structure of surface membrane lipid in rats. Although the content of phospholip... | 212,735 | [
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Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro. | A soluble adenovirus DNA replication system has been prepared in extracts of HeLa cells infected with the temperature-sensitive mutant H5ts125. These nuclear extracts synthesize full-sized viral DNA at 30 degrees but are temperature sensitive in this function at 38 degrees. A 72,000-dalton DNA-binding protein purified ... | 212,742 | [
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Involvement of brain cyclic AMP in the acute and chronic effects of morphine in the rat. | Incubation of cerebral cortical slices of rat brain with 3H-adenosine in the presence of varying concentrations of morphine in vitro resulted in a dose-related increase in 3H-cAMP formation. In in vivo experiments, the rate of 3H-cAMP formation in cortical slices both 45 min and 4 h after the acute s.c. administration ... | 212,767 | [
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The resistance to reinfection of tracheal organ cultures from chickens previously infected with avian infections bronchitis virus. | Lower titres of avian infectious bronchitis (AIB) virus were found following the infection of tracheal organ cultures prepared from chickens that had been given AIB virus intranasally six weeks previously than were found following the infection of organ cultures prepared from untreated or from passively-immune chickens... | 212,798 | [
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Prospects of vaccines against cancer in man. | Preventive immunization is the cheapest and most effective approach to the management of epidemic disease. Certain forms of cancer, including Burkitt's lymphoma, carcinoma of the cervix, primary liver cancer, acute leukaemia and breast cancer show many characteristics of epidemic disease, and the possibility of produci... | 212,839 | [
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Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. | The fine structure of the different cell types constituting a primary malignant giant cell tumor of bone has been studied and the localization of acid phosphatase in relation to the subcellular organelles been demonstrated. Three distinct cell types with characteristic ultrastructural features were observed: giant cell... | 212,864 | [
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[Nucleotide pool of the brains of rats during different stages of dying]. | Composition of acid-extractable fraction of nucleotides was studied in brain of dying rats after acute hemorrhage. Within the first 5 min content of ATP, GTP, UTP, GDP, UDP and NAD was distinctly decreased; content of AMP, GMP, IMP, CMP, nucleosides and nitrogen bases was markedly increased. Within the following 30 min... | 212,868 | [
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[Intestinal hemorrhage in Klippel-Trenaunay syndrome]. | It is reported on a 21-year-old patient with Klippel-Trenaunay's syndrome and simultaneous intestinal haemorrhage. Anamnesis and histological findings are discussed and the problems of therapy are explained. In the discussion the knowledge of the peripheral angiodysplasias and their differential diagnosis in literature... | 212,884 | [
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Analysis of function-related interactions of ATP, sodium and potassium ions with Na+- and K+-transporting ATPase studied with a thiol reagent as tool. | The paper describes the interaction of ATP, Na+ and K+ with (NaK)-ATPase exploiting the inactivation by reaction with NBD-chloride as an analytical tool for the evaluation of enzyme ligandation with the various effectors. 1. The inactivation of (NaK)-ATPase by reaction with NBD-chloride showing under all conditions stu... | 212,908 | [
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Herpes simplex virus replication in pheochromocytoma cell line that responds to nerve growth factor. | Cultured cells of neural origin (PC-12, pheochromocytoma cell line) respond to nerve growth factor (NGF) by extending neurites. These cells whether treated with NGF or not can be infected with herpes simplex virus and produce progeny virus. Viral antigens are detected on the cell surface and fusion of cells to form pol... | 212,925 | [
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Immunocytochemical evidence of SV 40-related T antigen in two human brain tumours of ependymal origin. | A series of thirty-time human brain tumours has been screened for the presence or absence of SV 40-related T antigen by the direct and indirect immunoperoxidase techniques. Two tumours (an ependymoma and a choroid plexus papilloma) of ependymal origin revealed markedly positive nuclear staining for T antigen both in in... | 212,932 | [
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Fibrous histiocytoma of the trachea. | The light and electron microscopic features of a fibrous histiocytoma of the trachea that occurred in a 15-year-old Caucasian girl are presented. Emphasis is placed on the aggresive behavior and the importance of early recognition of the lesion in an unusual location. | 212,945 | [
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Detection of early "significant" antibody responses in paired sera by the use of an automated bovine parainfluenza-3 hemagglutination-inhibition system. | An automated bovine parainfluenza-3 hemagglutination-inhibition system was used to detect small increases (15--20%) in specific antibody titer between paired bovine sera collected three days apart. Automated and manual parainfluenza-3 hemagglutination-inhibition test procedures were compared as methods for the serologi... | 212,948 | [
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Correlation of clinical and virus-specific immune responses following levamisole therapy of recurrent herpes progenitalis. | Patients with herpes progenitalis recurring every 14--28 days were treated with levamisole 150 mg orally twice weekly in an open trial to evaluate the relationship between immunomodulation and clinical response. Eight of 12 patients studied for 4--9 months reported a decrease in the frequency of recurrences. Enhanced v... | 212,971 | [
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Phosphorylation of glucose in isolated rat hepatocytes. Sigmoidal kinetics explained by the activity of glucokinase alone. | The conversion of glucose into glucose 6-phosphate in an extract of isolated rat hepatocytes incubated in the presence of MgATP was studied spectrophotometrically at 340nm and also by a radiochemical procedure based on the release of (3)H from [2-(3)H]glucose. Both methods gave similar results. The glucose-saturation c... | 213,056 | [
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The involvement of phosphatidate phosphohydrolase and phospholipase A activities in the control of hepatic glycerolipid synthesis. Effects of acute feeding with glucose, fructose, sorbitol, glycerol and ethanol. | Rats were fed by stomach tube with a single dose of glucose, sorbitol, fructose, glycerol or ethanol of equivalent energy contents or with 0.15 M-NaCl. They were killed 6 h later and the relative rates of phosphatidate deacylation and dephosphorylation measured in the microsomal and supernatant fractions of the livers.... | 213,059 | [
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Prolyl hydroxylase and collagen biosynthesis in rat liver following varying degrees of partial hepatectomy. | Prolyl hydroxylase activity and collagen biosynthesis have been measured at intervals following 2 extents of hepatic resection in rats. Prolyl hydroxylase activity is validated as a measure of collagen biosynthesis. The levels rise to a peak at 72 h and thereafter decline. The implications for the process of liver rege... | 213,093 | [
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Chemical modification studies on the Ca2+-dependent protein modulator: the role of methionine residues in the activation of cyclic nucleotide phosphodiesterase. | Methionine residues have been implicated in the activation of cyclic nucleotide phosphodiesterase by the Ca2+-dependent protein modulator [Walsh, M., & Stevens, F.C. (1977) Biochemistry 16,2742-2749]. Treatment of the modulator with N-chlorosuccinimide in the presence of Ca2+ resulted in selective oxidation of meth... | 213,097 | [
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The role of lipid-protein interactions in NADH-cytochrome c reductase (rotenone-insensitive) of rat liver mitochondria. | The phospholipid depletion of rat liver mitochondria, induced by acetoneextraction or by digestion with phospholipase A2 or phospholipase C, greatly inhibited the activity of NADH-cytochrome c reductase (rotenone-insensitive). A great decrease of the reductase activity also occurred in isolated outer mitochondrial memb... | 213,108 | [
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Variable chlorophyll a fluorescence from P-700 enriched photosystem I particles dependent on the redox state of the reaction centre. | 1. Photosystem I particles enriched in P-700 prepared by Triton X-100 treatment of chloroplasts show a light-induced increase in fluorescence yield of more than 100% in the presence of dithionite but not in its absence. 2. Steady state light maintains the P-700, of these particles, in the oxidised state when ascorbate ... | 213,109 | [
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Modeling the role of cyclic AMP in catabolite repression of inducible enzyme biosynthesis in microbial cells. | Modeling the role of cyclic AMP (cAMP) in catabolite repression of inducible enzyme production in microbial cells was studied. A catabolite repression index, F, was defined based on the postulation that complex formation occurs between RNA polymerase (RNAP) and DNA, and shifting from the inert form to the open form of ... | 213,139 | [
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Adrenocorticotrophic hormone fragments mimic the effect of morphine in vitro. | 1 Fragments of the N terminal part of adrenocorticotrophic hormone (ACTH) inhibited the electrically evoked contractions of the mouse vas deferens. This inhibition could be antagonized by naloxone. 2 The same fragments displaced radiolabelled morphine from morphine antiserum. 3 Structure-activity relationship studies s... | 213,154 | [
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Possible serotonin-agonist action of veratramine. | Veratramine produces a characteristic excitatory action on the central nervous system, producing both tremor and a characteristic "struggling" behavior. This behavioral excitation is accompanied by changes in serotonin content in hypothalamus. The central serotonin agonist methysergide in doses of 5--15 mg per kg produ... | 213,177 | [
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Undifferentiated sarcoma of the kidney: a tumor of childhood with histopathologic and clinical characteristics distinct from Wilms' tumor. | The pathological and clinical features of 123 patients with Wilms' tumor diagnosed between 1961 and 1977 were analyzed. A subgroup of nine patients with distinctive histology characterized by the presence of exclusively sarcomatous elements was identified. These patients were indistinguishable clinically from the other... | 213,187 | [
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Species differences in the hepatic response to mirex: ultrastructural and histochemical studies. | Mirex was fed at levels of 1, 5, 15, and 30 ppm to mice, 5 and 30 ppm to rats, while monkeys received the chemical by stomach tube at levels of 0.25 and 1 mg/kg (equal to 5 and 20 ppm). Mice were killed and their livers obtained at 2, 4, 6, 9, 10, 15 and 18 months, whereas rats were killed and surgical biopsies were ta... | 213,253 | [
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Studies on adrenaline-induced lipolysis in adrenalectomized rats. | In a short-term study, adrenaline-induced lipolysis was less in adrenalectomized rats than in controls, though the cyclic AMP accumulation was not different. In adrenalectomized rats treated with corticosterone, lipase activity was as low as in untreated adrenalectomized rats, although adrenaline-induced lipolysis was ... | 213,260 | [
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beta-Glucuronidase activity in trained red and white skeletal muscle of mice. | We studied the effects of prolonged running exercise (5 days a week, 1.5 h per day at a speed of 17.6 m/min) on the activity of some acid hydrolases (beta-glucuronidase, beta-N-acetylglucosaminidase, acid phosphatase and cathepsin D) and three enzymes of energy metabolism (cytochrome c oxidase, lactate dehydrogenase an... | 213,265 | [
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Isolation of precursors of cytochrome oxidase from Neurospora crassa: application of subunit-specific antibodies and protein A from Staphylococcus aureus. | A novel immunological procedure has been applied for the isolation of precursors of cytochrome oxidase. It involves antibodies to individual subunits of the oxidase and protein A from Staphylococcus aureus linked to a Sepharose support. Unassembled (free) 'subunits' as well as a labile complex containing five polypepti... | 213,273 | [
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Effects of diethyldithiocarbamate and fusaric acid upon memory storage processes in rats. | Diethyldithiocarbamate (DDC) and fusaric acid (FA), administered immediately posttraining, disrupted retention performance of rats trained on a one-trial inhibitory avoidance task. Posttraining DDC disrupted retention performance if the treatment was delayed up to at least 24 h (but not 72 h) after training. A single D... | 213,292 | [
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Inhibition of ovarian luteinizing hormone (LH) and follicle-stimulating hormone receptor levels with an LH-releasing hormone agonist during the estrous cycle in the rat. | A single injection of the luteinizing hormone (LH)-releasing hormone (LHRH) agonist [D-Ala6,des-Gly-NH2(10)]LHRH ethylamide to female rats on diestrus I produced a marked reduction in ovarian LH/human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH) receptor levels, uterine weight, and plasma progest... | 213,320 | [
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Transport of phosphate in membrane vesicles from mouse fibroblasts transformed by simian virus 40. | Membrane vesicles were prepared from mouse fibroblasts transformed by SV40 virus (SV3T3). Following disruption of the cells by nitrogen cavitation, the membrane vesicles were obtained by differential centrifugation. As measured by enzyme markers, they consist mainly of membrane from the plasma membrane and smooth and r... | 213,430 | [
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Metabolite control of L-fucose utilization. | Thyroid fucokinase is responsive to a number of metabolites which might serve in a regulatory capacity. In addition to inhibition by ADP and stimulation by GMP, fucokinase responds selectively to a series of nucleotide sugars. Of those studied, only guanine nucleotide sugars moderate the activity of the enzyme. GDP-alp... | 213,433 | [
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... |
Effect of adenosine 3':5'-monophosphate and guanosine 3':5'-monophosphate on RNA release from isolated nuclei. | The addition of physiological concentrations of either cAMP or cGMP stimulated the release of RNA from isolated prelabeled rat liver nuclei to a fortified cytosol in a cell-free system. The released RNA was shown to be primarily mRNA by its binding to oligo(dT)-cellulose and its sedimentation profile. Treatment of rats... | 213,435 | [
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Epstein-Barr virus in somatic cell hybrids between mouse cells and human nasopharyngeal carcinoma cells. | Somatic cell hybrids between mouse cells and cells derived directly from NPC biopsies were produced in order to study the association of the Epstein-Barr virus (EBV) genome and the expression of Epstein-Barr nuclear antigen (EBNA) with the human chromosome(s). All attempts to correlate the presence of EBV-DNA and the e... | 213,442 | [
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... |
Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. | In a blind study, 14 isolates of herpes simplex virus type 1 (HSV-1) that included nine isolates from a temporal cluster of HSV infections in a hospital Pediatric Intensive Care Unit and five unrelated isolates were analyzed by digestion of their DNA with four restriction endonucleases. These enzymes (HsuI, BglII, EcoR... | 213,496 | [
0.006426952,
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0.1070265,
0.1050704,
0.1279493,
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0.03... |
Effects of secretagogues and theophylline on canine gastric mucosal cyclic nucleotides. | cAMP and cGMP concentrations were measured in gastric mucosa in 18 anesthetized mongrel dogs receiving infusions of histamine (16 microgram/kg/hr), pentagastrin (6 microgram/kg/hr), bethanechol (10 microgram/kg/min), and theophylline (150 mg bolus, then 10 mg/min). The possible synergistic effect of continuous theophyl... | 213,513 | [
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0.09098867,
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0.1648026,
0.3111902,
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-0.1119... |
The binding isotherms for the interaction of 5-doxyl stearic acid with bovine and human albumin. | Binding isotherms for the interaction of 5-doxyl stearic acid with bovine and human albumin are reported. The critical micelle concentration (CMC) and the limiting solubility of 5-doxyl stearic acid were determined using the electron spin resonance (ESR)-spin label method. The CMC and the limiting solubility of this sp... | 213,518 | [
-0.009467517,
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0.09209073,
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0.01226531,
0.2167776,
0.1494759,
0.1274833,... |
Psychiatric patients' perceptions of their milieu therapy program. | This study was designed to provide information concerning psychiatric patients' perceptions of their individual treatment program in an inpatient treatment facility with an established therapeutic milieu. The responses of 24 patients aged 16 to 69 years to an 8-item questionnaire, developed and administered by the inve... | 213,562 | [
-0.1874582,
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0.09266406,
0.2146827,
0.03182264,
... |
Coxsackievirus in an infant chimpanzee. | Coxsackie B viruses may cause a severe, often fatal, illness in newborn and infant human subjects. As recorded in this case, infant chimpanzees respond similarly to Coxsackie B-5 virus. | 213,604 | [
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0.2565854,
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Cyclic nucleotide concentrations in 7.12-dimethylbenz[a]anthracene-induced pancreatic cancer in rats. | Pancreas cancer was induced in noninbred male Holtzman rats by the implantation of beeswax containing 7.12-dimethylbenz[a]anthracene (DMBA) into the "head" of the pancreas. The tumors that developed 4--6 months later were examined for their cyclic AMP and cyclic GMP levels. The lesions could be considered in one of two... | 213,611 | [
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0.151816,
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0.4674433,
0.1819919,
0.03712225,
... |
Stimulatory effect of immunization on tumor induction by Moloney murine sarcoma virus. | Adult mice were immunized with varying doses of inactivated Moloney murine leukemia virus (M-MuLV). Eight weeks after immunization, mice were challenged with a dose of Moloney murine sarcoma virus (M-MuSV) that could induce tumors in approximately 50% of normal animals. Mice immunized with high doses of M-MuLV (10(10) ... | 213,613 | [
-0.3384554,
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0.2816434,
0.3374946,
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Primary cytomegalovirus and opportunistic infections. Incidence in renal transplant recipients. | Thirty-five renal allograft recipients were studied concerning the relationship between cytomegalovirus (CMV), herpes simplex virus (HSV), and opportunistic bacterial and fungal infections. The incidence of opportunistic infections was determined for patients whose tests prior to transplantation were seronegative in co... | 213,620 | [
0.04149571,
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0.1907094,
0.2577023,
-0.1034364,... |
Alcian blue staining intestinal goblet cell antigen (GOA): a marker for gastric signet ring cell and colonic colloidal carcinoma. | An Alcian blue staining, perchloric acid-soluble, antigenic acidic mucosubstance (GOA) was purified from human gastric signet ring cell carcinoma with DEAE-cellulose chromatography, Seqhadex G-200 and preparative polycrylamide gel electrophoresis. Specific antisera were raised which reacted in indirect immunoenzyme his... | 213,641 | [
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0.1243632,
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0.07723617,
0.574684,
0.2097488,
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0.194903... |
Angiography in the diagnosis and management of extracranial vascular lesions of the head and neck. | The angiographic features of various lesions of the head and neck are presented. Angiographically, cavernous hemangiomas display large venous lakes with calcified phleboliths. Arteriovenous malformations reveal massive tumor stain with well delineated feeding vessels from multiple systems. Chemodectomas and juvenile na... | 213,664 | [
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0.2509938,
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0... |
[Paramagnetic properties of the conidial pigments of Aspergillus niger and Penicillium notatum fungi isolated from the mesosphere]. | The conidia of Aspergillus niger and Penicillium notatum detected in the upper atmospheric layers of the Earth (58--77 km) were found to contain stable paramagnetic centres (PMC) at concentrations of 0.2 X 10(18) and 1.6 X 10(18) per gram of dry biomass, respectively. Aspergillin, the black pigment of Asp. niger, was s... | 213,700 | [
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0.2534589,
0.6636164,
0.004488228,
0.07653932... |
Defective high-density lipoprotein composition in patients on chronic hemodialysis. A possible mechanism for accelerated atherosclerosis. | We determined serum high-density lipoprotein cholesterol content and analyzed the approtein structure of the various lipoprotein fractions in 21 patients on chronic hemodialysis. High-density lipoprotein cholesterol was significantly reduced in all patients as compared with 11 normal persons (mean +/-1 standard deviati... | 213,715 | [
0.1798544,
0.2562119,
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0.05449338,
0.2693539,
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0.01816213,
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0.2257877,
0.28545,
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0.01820218,
0.240579,
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0.3265874,
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0.416588... |
Apoprotein A-I synthesis in normal intestinal mucosa and in Tangier disease. | To determine whether human small intestine synthesizes apoA-I, the major apoprotein of plasma high-density lipoproteins, we used immunofluorescence technics and monospecific antiserums to visualize apoA-I within intestinal epithelial cells from four normal subjects and one patient with Tangier disease. Biopsies from al... | 213,720 | [
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0.09412699,
0.07465801,
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... |
Multicore disease. Report of a case with lack of fibre type differentiation. | A six year old boy had congenital hypotonia and nonprogressive proximal muscular weakness, with mild abnormalities in the E. M. G. and normal serum enzyme levels. There was lack of fibre type differentiation in the quadriceps muscle biopsy. The fibres had high oxidative enzyme activity and low ATPase 9.4 activity. In a... | 213,746 | [
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0.2996662,
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0.4228447,
0.08673798,
0.1471455,
0.... |
[5-fluorouracil inhibits the collagenolytic activity of invasive colonic adenocarcinomas in vitro]. | By means of a biological assay for the enzyme collagenase the activity of this protease was examined in 12 invasive adenocarcinomas of the colon. In spite of considerable quantitative differences collagenolytic activity in the dimensions of 10(-3) units/mm theta tissue could be revealed in all cases. EDTA inhibited the... | 213,750 | [
0.0187928,
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0.172182,... |
Hypercholesterolemia and hyper-alpha-lipoproteinemia in schoolchildren. | Elevated levels of high-density lipoprotein cholesterol (C-HDL) can explain apparent hypercholesterolemia in some children, and high C-HDL levels may aggregate in families. In this study, 17 kindreds were identified by virture of hypercholesterolemic proband children whose hypercholesterolemia was accounted for the ele... | 213,762 | [
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0.... |
Lipoproteins removed from serum and plasma by membrane filtration. | Tangential (crossflow) filtration of a plasma/serum mixture through 0.2 micrometer-poresize polycarbonate track-etch membrane filters (PC) at pressures less than 10 psi removes low density lipoproteins (LDL) and very low density lipoproteins (VLDL) but not high density lipoproteins (HDL) from the filtrate. At pressures... | 213,774 | [
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... |
Impaired renal prostaglandin E2 biosynthesis in human hypertensive states. | Urinary Prostaglandin E2 (PGE2), a known indicator of renal production, was measured by specific radioimmunoassay in 111 normal volunteers, 85 patients with essential hypertension, 6 with renovascular hypertension, and 23 patients with primary aldosteronism. Women excreted less PGE2 than men in both normotensive and hy... | 213,795 | [
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... |
Determination of the crystalline fraction in bone and other mineralizing tissues within the histochemical range by electron spin resonance spectroscopy. | The theoretical principle based on the application of electron spin resonance technique for calculation of the crystallinity coefficient of mineralized tissues is presented. The method is based on measurements of radiation-induced stable paramagnetic centres derived from the crystalline fraction of tissue mineral. The ... | 213,811 | [
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Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase. | C6 glioma cells and B104 neuroblastoma cells both possess adenylate cyclase activity, but only C6 cells have beta-adrenergic receptors. However, when cocultured with B104 cells, C6 cells show a marked decrease in their ability to accumulate adenosine 3', 5'-monophosphate upon stimulation with beta receptor agonists. Si... | 213,832 | [
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0.581358,
0.02174422,
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... |
[Etiology of hemoptyses]. | From hemoptyses as main symptom for the admission of patients during 1975 and 1976 in the pulmonary disease department of a parisian hospital, a retrospective study of the causes of hemoptyses is made by the authors. In 18% of the cases, hemoptysis was the unique revealing symptom of the disease. Tuberculosis and cance... | 213,834 | [
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0.2312199,
0.1235702,
0.2559215,
0.1107308,
-0.1304487,
... |
[System e in acute hepatitis B]. | HBeAg and Ab are investigated by simple radial immunodiffusion in dextrane following Magnius. 14 patients (28%) were HBeAg positive and 2 patients HBeAb positive (4%). HBsAg subtyping was ad in 6 cases and ay in further 5. No relation was found between both determinants and HBeAg. Six of the 10 patients with HBeAg in t... | 213,838 | [
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0.009350129,
0.5363473,
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0.1... |
[Original management in motor, personality and behavior disturbances in ethylic patients in a department of internal medicine (author's transl)]. | 33 ethylic patients with motor, personality and behavior disturbances have been treated successfully by tiapride. An oral dose of 5 mg/kg per day was observed to be sufficient in the treatment of lingual and hand tremors. However, in presence of behavior and/or personality disturbances and in predelirium the intramuscu... | 213,839 | [
-0.2910386,
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0.0561749,
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0.3367859,
-0.1058607,
0.3272952,
0.1140665,
-... |
[Detection of collagenase in passive haemagglutination using collagen-coated erythrocytes (author's transl)]. | Human rheumatoid arthritis (RA) collagenase and bacterial collagenase were shown to agglutinate collagen-coated erythrocytes. Native collagens of type I and type II reacted equally well, while denatured collagens showed less distinct agglutination activity. The sensitivity of the method for the detection of purified ba... | 213,904 | [
0.1058296,
0.1875343,
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0.2340438,
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0.3528283,
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0.1744153,
0.562317,
0.185559,
0.1478999,
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0.1459462,
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0.08376412,
0.4064357,
0.1246909,
-0.09913695,
0.090505... |
Cholinergic influences on hypothalamic-pituitary-adrenocortical activity of stressed rats: an approach utilizing choline deficient diets. | Male rats were placed on choline (Ch) deficient diets for 3 to 14 days, without and with Ch (normal and large doses) supplemented in the drinking water, to determine whether altering the availability of Ch would affect the cholinergic system in relation to the latter's role in modulating the hypothalamic-pituitary-adre... | 213,921 | [
-0.2602841,
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0.20688,
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0.1448705,
-0.1383484,
-0.009611391,
-0.1218848,
-0.1602646,
0.1876093... |
Comparison of small hepatitis B surface antigen particles and human serum low density lipoprotein molecules by electron microscopy. | The small spherical particles associated with hepatitis B surface antigen (HBsAg) could be distinguished from the low density lipoprotein (LDL) molecules in human serum by examination of coded, negatively stained preparations. The HBsAg associated particles showed a more marked contrast against the background than LDL.... | 213,934 | [
0.03112103,
0.4205816,
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0.1684804,
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0.1793393,
0.06919084,
0.1473125,
0.2507698,
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-0.1053777,
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0.3995155,
0.01194579,
0.02667527,
-0.164308,
0.0... |
Plasma high-density lipoproteins and ischemic heart disease: studies in a large kindred with familial hypercholesterolemia. | The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and ... | 214,000 | [
-0.04946721,
0.147238,
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-0.100085,
0.3832483,
0.2818421,
0.02905318,
... |
Botulism: electrophysiological studies. | In a patient with botulism type B, electrophysiological studies showed: (1) a pattern in the repetitive nerve stimulation test resembling that found in the Eaton-Lambert syndrome but without any significant increment at high rates of stimulation or posttetanic exhaustion phenomenon; (2) a prominent response to guanidin... | 214,021 | [
-0.158103,
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0.04661774,
-0.1272683,
-0.225647,
-0.003886069,
-0.1047552,
0.3290461,
-0.02178138,
0.01466829,
-0.2931243,
-0.09660206,
-0.3461615,
0.2501615,
0.09856647,
-0.3998134,
0.1877062,
0.1662608,
0.272337,
... |
Mixed intracranial sarcomas: rare forms and a new association with previous radiation therapy. | The first two instances of mixed sarcoma-glioblastoma with a history of therapeutic irradiation to the head are reported, both occurring within one year of radiation therapy (for pituitary adenoma and residual meningioma). Two novel variants of mixed sarcomas of brain with extreme tumor metaplasia (fibromyxoosteochondr... | 214,026 | [
-0.4779416,
-0.03918255,
0.1179925,
-0.3362409,
-0.1067515,
-0.3893856,
-0.2934342,
-0.01825278,
0.03414024,
0.3656041,
0.1870867,
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-0.1056505,
-0.3357304,
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-0.02991436,
-0.1217957,
-0.1064629,
0.1746798,
0.1400395,
0.1939858,
-0.068263... |
Fine structure of the dome in Peyer's patches of mice. | The dome area of Peyer's patches in adult mice was studied by electron microscopy. The cellular constituents of the area are lymphocytes, plasma cells, macrophages and reticular cells. Macrophages are filled with numerous lysosomal bodies containing dead lymphocytes or plasma cells. The epithelium covering the dome is ... | 214,052 | [
-0.2757648,
-0.3156637,
0.0874133,
0.2003461,
0.2317659,
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0.1736391,
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0.06708196,
0.4273839,
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0.0139861,
0.198983,
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0.07412591,
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-0.2667044,
0.2100065,
0.1067037,
-0.1753747,
0.4616345,
-0.1321552,
-0.... |
Purification and properties of bovine liver lysosomal adenosine 5'-phosphosulphate sulphohydrolase. A non-specific enzyme with pyrophosphatase and phosphodiesterase activities. | Bovine liver lysosomal adenosine 5'-phosphosulphate sulphohydrolase (EC 3.6.2.1) was purified to apparent homogeneity. The molecular weight of the enzyme was 53 000 by sodium dodecyl sulphate polyacrylamide gel electrophoresis and 56 000 by BioGel P-150 gel filtration. The substrate specificity of the enzyme was studie... | 214,136 | [
-0.1920851,
-0.138819,
-0.1364578,
0.1191363,
-0.07049199,
-0.1047608,
-0.1466143,
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0.06429746,
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0.1343536,
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0.19011,
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0.02642165,
0.172805,
0.1521048,
0.06306494,
0.1801137,
-0.1868837,
0.... |
A possible role for guanosine 3',5'-monophosphate in the stimulus-secretion coupling in exocrine pancreas. | Carbamylcholine, caerulein and cholecystokinin octapeptide rapidly increased the cyclic GMP concentration and amylase secretion in isolated guinea pig pancreatic slices. The cyclic GMP concentration was increased eight-fold over the basal concentration in 30 s, with concomitant increase in the rate of amylase secretion... | 214,145 | [
-0.05944728,
-0.4783083,
-0.3045034,
-0.09122107,
0.1040327,
0.06427397,
-0.3361656,
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0.03149254,
-0.1930125,
-0.1936211,
-0.03774059,
-0.02066754,
0.2542545,
-0.32082,
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-0.8588752,
0.04790794,
0.02901769,
0.08376808,
0.5199891,
-0.02796001,
0.06569... |
Modulation of adenylate cyclase activity by sulfated glycosaminoglycans. I. Inhibition by heparin of gonadotrophin-stimulated ovarian adenylate cyclase. | Heparin inhibits (I50 = 2 microgram/ml) the activity of luteinizing hormone and human chorionic gonadotropin-stimulated adenylate cyclase in purified rat ovarian plasma membranes. Unstimulated enzyme activity and activity stimulated by NaF, GTP or guanosine 5'-(beta,gamma-imido)triphosphate were inhibited to a lesser e... | 214,154 | [
-0.0982238,
0.1830604,
-0.4286792,
0.07666845,
0.1329884,
-0.008924033,
-0.05615133,
0.2158083,
-0.04117635,
0.1098666,
0.07112233,
-0.1840623,
0.01244003,
-0.08415797,
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0.1388276,
-0.5525532,
0.09213933,
-0.08306982,
0.1254939,
0.4719624,
-0.0779838,
0.06113199... |
Effect of urethan on the induction of ornithine decarboxylase in regenerating rat liver. | The effect of urethan on the induction of ornithine decarboxylase in the early stage of the regeneration of rat liver was studied. The induced activity of ornithine decarboxylase was suppressed by administration of urethan immediately after partial hepatectomy. Although ornithine decarboxylase was induced biphasically ... | 214,156 | [
0.04854072,
-0.1606186,
-0.05725065,
-0.2211365,
0.3896771,
-0.2107572,
-0.1110944,
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0.2384719,
0.004674925,
-0.04768109,
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0.3515014,
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0.284123,
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0.0298011,
0.07101364,
0.04882304,
0.3570777,
0.1179642,
-0.07936189,... |
Regulation of purine biosynthesis in cultured Drosophila melanogaster cells: I.--Conditional activity of hypoxanthine-guanine-phosphoribosyltransferase and 5-nucleotidase. | In cultured cells established from Drosophila melanogaster embryos, and grown in usual medium, no hypoxanthine-guanine-phosphoribosyl transferase (HG-PRT) could be measured, and only traces of 5'-nucleotidase activity were detectable. On the contrary, it was observed that if the same medium is supplemented with purine ... | 214,163 | [
-0.08146866,
-0.1768799,
-0.1742441,
0.1687387,
0.2027346,
0.02539403,
0.3527336,
0.07671547,
0.08591757,
-0.3570453,
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0.6344428,
0.1372072,
0.2237519,
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0.3660257,
-0.3972628,
0.1071395,
-0.04683312,
-0.03074939,
0.4030535,
0.1841332,
-0.2938811,
... |
[Regulatory interaction between the respiratory chain of mitochondria and the oxidative system of the endoplasmic reticulum]. | A regulation mechanism of the interaction of microsomal oxidases and mitochondrial respiratory chain with oxidase substrates is suggested. Quantitative comparison of their affinity to microsomal oxidases and mitochondrial NADH-dehydrogenase is carried out. The interaction with both systems is found to be hydrophobic. I... | 214,167 | [
-0.05147294,
0.03537158,
0.09260392,
0.2507069,
0.09135077,
-0.2580743,
-0.1288569,
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0.17277,
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-0.2069982,
0.2276226,
0.2501321,
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0.06232268,
-0.6497873,
0.1764245,
-0.05305079,
0.1330482,
0.3188498,
0.1016809,
0.2147564,
0.... |
[Separation and investigation of the regulatory properties of two forms of cyclic nucleotide phosphodiesterase from rabbit heart--sensitive and insensitive to Ca-dependent regulator protein]. | Two forms of cyclic nucleotide phosphodiesterase (ES 3.1.4.17)--PDE-I and PDE-II--sensitive and resistant to Ca-dependent protein regulator, were isolated from the soluble fraction of rabbit heart by chromatography on DEAE-cellulose. Both forms of enzyme are inhibited by 30--50% by Ca2+ (10(-4) M). Addition of Ca-depen... | 214,170 | [
-0.1879353,
-0.02053056,
-0.09044992,
-0.2416531,
0.06857115,
-0.1868118,
-0.1778866,
0.1421051,
0.1231554,
-0.06289497,
0.1030495,
0.299585,
0.004176028,
-0.1636012,
-0.8642866,
-0.02769267,
-0.7497429,
0.05923718,
0.09779895,
0.3279115,
0.3765476,
0.212383,
-0.2840506,
... |
Translation of procollagen messenger RNA in a cell free system derived from wheat germ: hydroxylation of prolyl residues in the product. | Ribonucleic acid extracted from chick embryo calvaria directs the synthesis of a collagenous product in a cell-free system. A portion of the prolyl residues incorporated into this protein can be hydroxylated in vitro by prolyl hydroxylase as demonstrated by the release of 3H-H20 from 3H-proline and by the direct demons... | 214,271 | [
-0.2258212,
-0.1026701,
-0.05572545,
0.1662197,
-0.05489677,
-0.1644,
-0.05889563,
0.1226353,
0.1559796,
0.1769252,
0.2404483,
0.21279,
0.09823453,
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-0.3664567,
0.008547779,
-0.08913998,
0.2661783,
-0.4606577,
-0.01616599,
0.5791592,
0.2801462,
-0.1651451,
0.... |
Acute infantile gastroenteritis caused by rotavirus in Japan. | We had an outbreak of acute infantile gastroenteritis accompanied by milky-white stool (called Hakuri in Japanese) during the winters of 1976 and 1977. Stool specimens collected from 72 cases of Hakuri were studied by negative-staining electron microscopy. Rotavirus was detected with a very high frequency (89%). Rotavi... | 214,305 | [
0.04862715,
-0.2196212,
-0.03290964,
0.07943153,
0.4536884,
0.002720014,
-0.1876236,
0.2226316,
0.06575765,
-0.3077619,
0.2512166,
0.2695979,
-0.0187011,
0.1890683,
-0.217232,
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-0.4012994,
0.4192472,
0.01683548,
0.02537086,
0.3266485,
0.3058021,
-0.09589241,
... |
Viral adenosine triphosphatase. | The catalytic and immunological properties of an adenosine triphosphatase from different types of virus have been studied. The avian myeloblastosis virus has been found to be specialized in holding this enzyme in a highly active state as compared to other virus with respect to their host cell enzyme. Catalytically myel... | 214,324 | [
-0.2191105,
-0.1950851,
-0.356402,
-0.3798211,
0.1969933,
-0.2551932,
-0.03752942,
0.04451999,
-0.4249058,
0.1357101,
0.2602356,
-0.03301193,
-0.09784602,
0.0999409,
-0.6654949,
-0.08445333,
-0.2535936,
0.0922072,
0.1305362,
0.2069196,
0.5076793,
-0.1915673,
-0.3216363,
... |
Reduction in FSH receptors in the rat testis by injection of homologous hormone. | Intratesticular injection of 25 microgram rat FSH into rats under continuous urethane anaesthesia resulted 24 h later in a 50% reduction in binding sites for FSH in testicular homogenates. By 48 h after injection, receptor number usually returned to control values. Intratesticular injection of 125I-labelled rat RSH sho... | 214,362 | [
0.1710068,
-0.05749151,
-0.2195984,
-0.1196018,
0.1606973,
-0.2597919,
-0.2455948,
0.04020005,
-0.1465459,
0.1429022,
0.3253115,
0.1407852,
-0.06111147,
-0.1725615,
-0.3344334,
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-0.2841942,
-0.06060151,
0.06430188,
0.1825553,
0.1010574,
0.3722719,
-0.1434031,
... |
[Regulation of purine nucleotide biosynthesis in mutant Saccharomyces cerevisiae yeasts with increased sensitivity of the pathway for de novo synthesis to inhibition by exogenous guanine]. | Aza 165 and aza 238 Saccharomyces cerevisiae mutants characterized by a 2.5 times higher sensitivity of the de novo purine synthesis to the inhibitory effect of exogenous guanine, as compared with the wild type strain, have been selected by their sensitivity to 8-azaguanine. The exogenous guanine somewhat inhibits the ... | 214,373 | [
-0.2602367,
-0.3637622,
0.1104847,
-0.3230895,
0.361524,
0.0574632,
0.09791669,
0.01620115,
0.2073849,
-0.06306021,
0.1921414,
-0.255682,
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0.1497009,
-1.060504,
0.197816,
-0.6998786,
0.009756668,
-0.3904589,
0.3048817,
0.6893155,
0.2917485,
-0.3440639,
0.0399... |
Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. | Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. The type-specific antibodies were assayed by IHA... | 214,407 | [
-0.01701357,
-0.1889036,
-0.2562557,
-0.3495001,
-0.075611,
-0.2140436,
-0.3301954,
0.2994927,
0.05828433,
0.1347762,
0.2091968,
0.002260348,
-0.02911276,
0.09424253,
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-0.2977872,
-0.242788,
0.1172732,
-0.08419343,
-0.1616494,
0.1496145,
0.008170166,
-0.0924393... |
A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. | The biosynthesis of a secretory protein and a transmembrane viral glycoprotein are compared by two different experimental approaches. (a) NH2-terminal sequence analysis has been performed on various forms of the transmembrane glycoprotein of vesicular stomatitis virus synthesized in cell-free systems. The sequence data... | 214,427 | [
-0.3105446,
-0.3983852,
-0.2885177,
-0.02951191,
0.02352503,
-0.210139,
0.1136952,
-0.1285702,
0.1358903,
0.2912733,
0.05428052,
-0.08727375,
-0.0600601,
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0.06108712,
0.08809869,
-0.4841766,
-0.1132156,
0.2658072,
-0.1601388,
0.5098964,
0.1879455,
0.0164116,
... |
Characterization of NADH-cytochrome c reductase, a component of benzoate 1,2-dioxygenase system from Pseudomonas arvilla c-1. | NADH-cytochrome c reductase, a component of benzoate 1,2-dioxygenase system, was purified to homogeneity, as judged by sodium dodecyl sulfate disc gel electrophoresis and ultracentrifugation, from benzoate-induced cells of Pseudomonas arvilla. The molecular weight of the enzyme was determined to be 38,300 by sedimentat... | 214,433 | [
-0.06142313,
-0.1401628,
0.0466915,
0.2245334,
0.08347737,
-0.4746573,
0.0274766,
-0.0390529,
0.1166711,
0.00145978,
0.01027331,
0.1075269,
-0.1944642,
0.3774578,
-0.2817655,
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-0.3688516,
0.1775796,
0.4143983,
0.0638785,
0.1747585,
0.3043462,
-0.1140832,
0.0... |
Induction of metabolic changes and down regulation of bovine parathyroid hormone-responsive adenylate cyclase are dissociable in isolated osteoclastic and osteoblastic bone cells. | Bovine parathyroid hormone (PTH), dibutyryl cAMP, and calcium each induce similar metabolic changes in isolated bone cells. PTH and calcium, but not dibutyryl cAMP, result in desensitization of osteoclastic and osteoblastic bone cells to PTH. In osteoblastic cells, calcium effects are specific for PTH receptor.adenylat... | 214,443 | [
-0.03100722,
-0.2244207,
-0.0138454,
-0.08327366,
-0.2044965,
-0.4343658,
-0.1371438,
0.2558491,
0.08871832,
0.3609571,
-0.02010693,
-0.1407448,
-0.08220599,
-0.04938421,
-0.8538222,
-0.007498142,
-0.2716228,
0.08093538,
-0.08903605,
0.1596353,
0.1907732,
0.1970646,
-0.09... |
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