title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Pleiotropic drug resistance in cystic fibrosis fibroblasts: increased resistance to cyclic AMP. | In previous studies, cystic fibrosis (CF) fibroblasts were demonstrated to be resistant to the cytotoxic effects of ouabain, dexamethasone, and the sex hormones, dihydrotestosterone, 17beta-estradiol, and progesterone. We now show that CF fibroblasts also exhibit greatly increased resistance to the cytotoxic effects of... | 210,526 | [
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[Effect of denervation on carbohydrate metabolism in the liver]. | Activities of glucose-6-phosphatase, glucose-6-phosphate dehydrogenase and content of glycogen in liver as well as content of sugar in blood were studied after denervation of dog liver tissue. Activities of these enzymes were increased and content of glycogen in hepatocytes was decreased within 1-2 weeks after the dene... | 210,585 | [
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[Clinical aspects of trophoblastic tumors]. | Trophoblastic tumors are among the rare diseases in this country. The most important clinical aspects are demonstrated by references and personal experiences in the treatment of trophoblastic tumors. In many countries (SU, USA, GB, Japan) the treatment of trophoblastic tumors has been centralized.--The therapeutical st... | 210,605 | [
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Response of the atrial pacemaker to dobutamine. | The action of dobutamine, (+/-)-4- [2- [[3-(p-hydroxyphenyl)-1-methylpropyl]amino]ethyl] pyrocatechol hydrochloride was studied on the pacemaker of the isolated rat atria. The dose-chronotropic response curve showed a typical bell-dome shape of the sympathomimetic amines. Reserpinization of the animals did not change t... | 210,632 | [
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A proposed bioanthropological approach linking ritual and opiate addiction. | This paper presents preliminary conjectures about possible neurobiological relationships among seemingly disparate phenomena: religious rituals, native curing therapies, and the pharmacodynamic, psychological, and sociocultural components of opiate addiction. Central to the discussion is an analysis of the function of ... | 210,638 | [
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Tolyl-specific IgE antibodies in workders with hypersensitivity to toluene diisocyanate. | Incorporation of a p-tolyl (mono) isocyanate-human serum albumin (TMI-HSA) antigen conjugate into a solid phase radioimmunoassay permitted detection of tolyl-specific IgE antibodies in 3 of 4 workers with clinical hypersensitivity to toluene diisocyanate (TDI). By comparison 19 TDI-exposed, non-sensitized workers had a... | 210,646 | [
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Increased histidine and histamine content in the brain of chronic uremic rats. Cause of enhanced cerebral cyclic adenosine monophosphate in uremia? | In rats with experimental chronic renal insufficiency (90% nephrectomy) the histidine content in brain was increased (+ 35%) in spite of normal plasma values and decreased concentrations in the striated muscle (-23%). The finding of a raised histidine level in the brain seems to be a uremia specific disorder, probably ... | 210,651 | [
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Effect of immunization on the development of latent ganglionic infection in mice challenged intravaginally with herpes simplex virus types 1 and 2. | Immunization of BALB/c mice with virulent and avirulent strains of HSV-1 resulted in high levels of neutralizing antibody and protected against both the lethal effect of the virus and the development of a latent ganglionic infection when animals were challenged by the intravaginal route. In animals immunized with aviru... | 210,669 | [
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Acute asthma. Part II. The effects of therapy on heart rate and blood pressure. | This study evaluated cardiovascular effects of epinephrine in the treatment of asthma. Heart rates, systolic and diastolic blood pressures were monitored in 64 patients treated for acute asthma. Treatment regimens included subcutaneous epinephrine in doses of 0.1 to 0.5 mg. Pretreatment heart rates ranged from 64 to 13... | 210,667 | [
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GnRH membrane binding: identification, specificity, and quantification in nonpituitary tissues. | Utilizing biologically active 125I-labeled gonadotropin-releasing hormone (125I-GnRH), specific binding with two affinites [KA (high) = 3.2 x 10(8) M-1, KA (low) = 10(5) M-1] were identified in membrane preparations derived from the 10,800 x g pellet of rat pituitary. GnRH-specific low affinity sites (KA - 10(5) M-1) w... | 210,676 | [
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Malignant fibrous histiocytoma. Clinicopathologic and ultrastructural study of 12 cases. | The clinical and pathologic findings of 12 cases of malignant fibrous histiocytoma of the soft tissues are presented. The mean age of the patients (eight males and four females) was 64 years, and there was a strong predilection for localization in the extremities (10 cases). The lesion is of rather low-grade malignancy... | 210,684 | [
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Growth hormone secretion in Addison's disease. | Growth hormone secretion has been evaluated in patients with Addison's disease given T.R.H., A.C.T.H. or Glucagon i.v., or L-DOPA p.o. In those with the idiopathic, auto-immune variety the mean response to glucagon and L-DOPA was reduced when compared with that documented for patients in whom tuberculosis caused the le... | 210,706 | [
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Mixed longitudinal data on skeletal age from a group of Dutch children living in Utrecht and surroundings. | The height and weight of 1132 children, aged 8.0--17.0 years studied in 1970--72 in a semi-longitudinal survey in the Dental Institute of Utrecht, are compared with similar data from the national Dutch survey of 1965. Children measured in 1970--72 are somewhat taller than, but have the same weight as, those of the same... | 210,707 | [
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[The diagnosis of the main histological types of lung cancer by means of cytological smears (author's transl)]. | The paper emphasizes the possibility to distinguish types I, II and III (WHO classification) of lung cancer not only by means of single cells, but also of tissue solids in cytological smears. The morphologic criteria of tissue solids and their special patterns in the different main types of lung cancer are described. | 210,735 | [
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[Local cellular and tributary lymphocyte immunity in cancer of the breast. Diagnostic and prognostic evaluations]. | Following a review of the literature on breast cancer and local and lymph gland immunoreactive state, the results of histomorphological study on a series of 150 cases of breast and axillary lymphnode cancer with and without metastasis, are reported. On the basis of findings, stress is laid on the importance of a more s... | 210,742 | [
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Characterization of a new photoaffinity derivative of ouabain: labeling of the large polypeptide and of a proteolipid component of the Na, K-ATPase. | We have synthesized 2-nitro-5-azidobenzoyl (NAB) derivatives of ouabain as photoaffinity labels of the cardiac glyocoside binding site of Na, K-ATPase. [3HzNAB-ouabain was found to bind to the same number of sites on Na, K-ATPase (purified from pig kidney outer medulla) as ouabain (1.9 nmol/mg), with approximately the ... | 210,802 | [
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Do copper ions influence the reduction of ferricytochrome C by O-2? | Recently, it was suggested that the measured rate of reduction of ferricytochrome C by O-2 below pH 8, was too high in the presence of high concentrations of formate (Koppenol, W.H., Van Buuren, K.J.H., Butler J. and Braams, R. (1976) Biochim. Biophys. Acta 449, 157-168). The high values were attributed to the presence... | 210,805 | [
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The electric potential field around cytochrome c and the effect of ionic strength on reaction rates of horse cytochrome c. | 1. The electric potential fields around tuna ferri- and ferrocytochrome c were calculated assuming that (i) all of the lysines and arginines are protonated, (ii) all of the glutamic and aspartic acids and the terminal carboxylic acid are dissociated, and (iii) the haem has a net charge of +1e in the oxidized form. 2. N... | 210,807 | [
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Studies on the mechanism of inhibition of redox enzymes by substituted hydroxamic acids. | Substituted primary hydroxamic acids were found to inhibit the catalytic activity of a number of redox enzymes. The inhibition was not related to the nature of the metal-active site of the enzyme nor to the nature of the oxygen-containing substrate. Two easily available enzymes, mushroom tyrosinase (monophenol,dihydroy... | 210,815 | [
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Effects of polyamine hydrochlorides and salts on phosphoprotein phosphatase. | Polyamine hydrochlorides, NaCl and magnesium acetate stimulated the enzymatic dephosphorylation of phosphorylated H2B histone by two forms (large form, mol. wt. 250 000; small form, mol. wt. 30 000) of a pig heart phosphoprotein phosphatase (phosphoprotein phosphohydrolase, EC 3.1.3.16). These ionic compounds stimulate... | 210,824 | [
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Lack of altered cyclic nucleotide phosphodiesterase activity in the aorta and heart of the spontaneously hypertensive rat. | DEAE-cellulose chromatography demonstrated that the levels of the individual cyclic nucleotide phosphodiesterases were unchanged in the aorta and heart of the spontaneously hypertensive rat as compared with the normotensive control rat. Three peaks of cyclic nucleotide phosphodiesterases activity were observed in both ... | 210,834 | [
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Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins. | 1. During in vitro incubation of liposomes or unilamellar vesicles prepared from egg-yolk or rat-liver phosphatidylcholine with human, monkey or rat plasma the phospholipid becomes associated with a high molecular weight protein-containing component. 2. The phosphatidylcholine . protein complex thus formed co-chromatog... | 210,837 | [
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Influence of vincamine and piracetam on sleep--waking pattern of the cat. | The effect of Vincamine and Piracetam, two geriatric drugs, on sleep behavior of the laboratory cat was studied. The animals were chronically prepared for recording of the EEG of the cerebral cortex, the lateral geniculate body, and the hippocampus, and for recording of eye movements, the muscular tonus and respiration... | 210,850 | [
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Effects of 4-aminopyridine on neuromuscular transmission. | 4-Aminopyridine (4-AP) powerfully increases transmitter release from motor nerve terminals of rat and frog skeletal muscle in response to single nerve impulses. The drug also enhances transmitter release during repetitive nerve activity but, at D-tubocurarine-blocked endplates, only the first impulses cause increased t... | 210,882 | [
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Musculoskeletal deformities following treatment of Wilms' tumour. | Wilms' tumour is one of the most common neoplasms of infancy and childhood. Current treatment regimens result in a cure rate of about 80% for localized tumours but may also cause musculoskeletal deformities. Assessment of 21 patients previously treated for Wilms' tumour showed that all had flank atrophy on the treated ... | 210,920 | [
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Hamster embryo cells transformed by herpes simplex virus: reactions with adeno-associated satellite virus (AAV) and its adenovirus helpers. | We have studied the reactions of hamster embryo cells transformed by ultraviolet-inactivated herpes simplex type 2 (333-8-9 T cells) to infections with adeno-associated satellite virus (AAV) and its adenovirus helpers. Resident HSV structural antigens were not detectable in early or late passage of 333-8-9 T cells. AAV... | 210,924 | [
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Base specificity in the binding of benzo[a]pyrene diol epoxide to simian virus 40 DNA. | [14C]Simian virus 40 (SV40) DNA was reacted with [3H]7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene to give 0.60 adducts per genome. The modified DNA was digested to completion with Hind III restriction endonuclease and the 6 fragments isolated by polyacrylamide gel electrophoresis. Hydro... | 210,927 | [
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Acute and long-term cytogenetic effects of childhood cancer chemotherapy and radiotherapy. | Approximately 30 banded karyotypes per subject from the lymphocytes of 66 childhood cancer patients and 14 noncancer control subjects have been analyzed in an attempt to gauge the late effects of anticancer chemotherapy and chemotherapy plus radiotherapy on the genetic material, i.e., the chromosomes. The frequencies (... | 210,931 | [
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0.2402306,
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Cellular alterations dependent upon the polyoma virus Hr-t function: separation of mitogenic from transforming capacities. | Hr-t mutants of polyoma virus are restricted in their growth properties (host range) and defective in cell transformation and tumor induction. The present study indicates that these mutants have lost the ability to induce morphological transformation, but have retained a mitogenic function. Thus an early and dramatic d... | 210,955 | [
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0... |
[Rare electrophoretic variants of the proteins adenylate kinase 1, phosphoglucomutase 1 and 2, and transferrin (AK1, PGM1, PGM2, Tf) in two populations of French Guiana]. | Two small populations of inner French Guiana were investigated for red cell enzymes and serum proteins. Rare variants were found in four systems (AK1, PGM1, PGM2, Tf). Similarities between some of these variants and those found in other Amerindian populations indicate that these genetic markers may be valuable in studi... | 210,969 | [
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0.1597535,
-0.4690219,... |
Initiation of sperm motility in the mammalian epididymis. | Spermatozoa acquire the capacity for motility as they traverse the mammalian epididymis. The biochemical basis for this induction of motility is still largely unknown. Current theories are discussed and recent studies from the authors' laboratory are described which indicate that two separate processes are involved and... | 211,050 | [
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0.06436834,
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[Deprivation of "rapid" sleep by stimulation of the reticular formation of rats]. | Rats were repeatedly arused from REM sleep by the stimulation via implanted midbrain reticular electrodes. The 4-day seprivation reduced REM sleep by 50% whereas the slow-wave sleep was only reduced by 10%. There was no evidence of a disruption in the animal behaviour during the deprivation and no changes of emotional ... | 211,052 | [
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Distribution of adenylate cyclase among membrane fractions of rat liver. | Adenylate cyclase activity was detected in plasma membranes, Golgi apparatus, and endoplasmic reticulum from rat liver. Adenylate cyclase activities of purified membranes were determined biochemically by two methods. In one, the synthesis of radioactive cyclic AMP from ATalpha32P was monitored. In the other, the synthe... | 211,057 | [
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... |
Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. | Some of the deletions in the yeast Saccharomyces cerevisiae that encompass the CYC1 gene, which determines iso-1-cytochrome c, extend into the OSM1 gene, causing inhibition of growth on hypertonic media, and into the RAD7 gene, causing sensitivity to UV light. Two deletions (cyc1--363 and cyc1--367) encompass only the ... | 211,068 | [
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0.3201686,
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0.04211568,
... |
Suppression and enhancement of mitogen response in chickens infected with Marek's disease virus and the herpesvirus of turkeys. | The kinetics of phytohemagglutinin (PHA) response of peripheral blood lymphocytes from chickens infected with oncogenic Marek's disease (MD) virus (MDV) or nononcogenic herpesvirus of turkeys (HVT) was studied with a whole blood microassay. At about 7 days after inoculation, a depression in PHA response was observed in... | 211,085 | [
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0.3424639,
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-... |
Organ culture of adult mouse intestine IV. Stimulation of glucose-6-phosphatase in vitro. | Explants of adult mouse jejunum have been maintained in organ culture with or without fructose added to the medium in order to stimulate the intestinal glucose-6-phosphatase (G-6-Pase). When the fructose is added, at the beginning of the culture, a three-fold increase of G-6-Pase in measured during the first 24 h. If t... | 211,103 | [
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0.0964909,
0.327865,
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... |
Improved method for the histochemical demonstration of glucose-6-phosphatase activity. | Methodological studies on the histochemical technique for the demonstration of G6Pase activity showed that the occurrence of common artifacts: morphological destruction, extracellular precipitation of reaction product and nuclear staining are dependent on the concentration of lead nitrate, buffer and substrate. By stud... | 211,104 | [
0.04793982,
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0.2881385,
0.2291241,
0.3422929,
-0.087390... |
Focal loss of pigment in the Belgian Tervuren dog. | Hypopigmentation most commonly affecting the face and mouth of the Belgian Tervuren dog was characterized by an absence of melanocytes in the epidermis. Pigment loss usually occurred during young adulthood, and although there was partial repigmentation in some dogs, complete repigmentation did not occur. Treatment with... | 211,110 | [
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... |
Effects of antipain (a protease inhibitor) on respiration, viability, and excision of pyrimidine dimers in UV-irradiated Escherichia coli cells. | The protease inhibitor antipain increases the effectiveness of UV irradiation on cessation of respiration and cell killing in Escherichia coli B/r cultures without affecting excision of pyrimidine dimers. The actions are similar to those caused by cyclic AMP in irradiated cultures. | 211,114 | [
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Sodium polyanethole sulfonate: a new macrophage-dependent polymyxin-inhibitable, polyclonal B cell activator. | The anionic detergent sodium polyanethole sulfonate was found to activate mouse B lymphocytes to increased cell division and formation of plaque-forming cells, possibly by an indirect mechanism. An increased cell division was also obtained in guinea pig and in rabbit lymphooid cell cultures. A strong similarity was fou... | 211,164 | [
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0.4611605,
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... |
Simultaneous production of mouse endogenous virus and Rous sarcoma virus by Schmidt-Ruppin virus infected mouse cells. | Schmidt-Ruppin Rous sarcoma virus infected chick cells injected into newborn C3H/f mice gave rise to tumours at the site of inoculation. These tumours were transplantable in adult C3H/f mice and were able to induce tumours in the wing of adult Leghorn chickens. Tumour cells from the 18th passage in mice were used to es... | 211,179 | [
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... |
Attachment of herpes simplex virus to neurons and glial cells. | Cells of brain tissue of rabbits, rats and mice were dissociated and glial cells, neuronal perikarya and synaptosomes were separated by centrifugation on discontinuous Ficol gradients. HSV was shown to attach well to rat and rabbit glial cells and synaptosomes but not to neuronal perikarya. Of intracerebrally infected ... | 211,185 | [
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0.07098991,... |
Noradrenaline receptor sensitivity after chronic ethanol administration. | The effects of the central noradrenaline receptor stimulating agent clonidine on blood pressure, heart rate, and flexor reflex activity were studied in intact rats and in rats chronically treated with ethanol. The clonidine-induced changes were similar in ethanol-treated animals and in animals never subjected to ethano... | 211,201 | [
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0.... |
Physiological properties of afferents and synaptic reorganization in the rat cerebellum degranulated by postnatal X-irradiation. | Elimination of most granule, basket, and stellate interneurons in the rat cerebellum was achieved by repeated doses of low level x-irradiation applied during the first two weeks of postnatal life. Electrical stimulation of the brain stem and peripheral limbs was employed to investigate the properties of afferent cerebe... | 211,202 | [
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-0.072... |
Synthesis and antiviral acticity of some phosphates of the broad-spectrum antiviral nucleoside, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin). | 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide 5'-phosphate (2) was prepared and converted into the following derivatives: the 5'-phosphoramidate 3, the 5'-diphosphate 4, the 5'-triphosphate 5, and the cyclic 3',5'-phosphate 6. The cyclic 2',3'-phosphate 7 was prepared from the parent nucleoside, 1-beta-D-ribofura... | 211,234 | [
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Ependymomas, malignant tumors of pancreatic islets, and osteosarcomas induced in hamsters by BK virus, a human papovavirus. | BK virus (BKV), a human papovavirus, was inoculated iv into 3-week-old Syrian golden hamsters. Between 2 1/2 and 9 months after inoculation, 82% of the animals developed tumors. The induced neoplasms were ependymoma, carcinoma of the pancreatic islets, osteosarcoma, adenocarcinoma, angiosarcoma, angioma, lymphoma, and ... | 211,243 | [
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0.1185146,
0.2263969,
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-0.1568568,
... |
Measurements of the molecular size of the simian virus 40 large T antigen. | A measure of the molecular weight of the large simian virus 40 T antigen was sought by SDS-polyacrylamide gel electrophoresis, random-coil chromatography, and sedimentation-velocity analysis in a density gradient. Large T antigen obtained from a simian virus 40-transformed human cell line either by immunoprecipitation ... | 211,251 | [
-0.2711496,
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... |
Mapping early transcripts of herpes simplex virus type 1 by electron microscopy. | RNA displacement loop patterns in intact herpes simplex virus DNA and herpes simplex virus DNA restriction fragments indicate that viral RNA associated with polyribosomes early after infection is transcribed from three major areas of the genome. One area of early transcription is in the short segment of the viral DNA a... | 211,255 | [
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0.06487574,... |
Heterogeneity of Epstein-Barr virus. III. Comparison of a transforming and a nontransforming virus by partial denaturation mapping of their DNAs. | The DNAs of a transforming and a nontransforming Epstein-Barr virus strain, B95-8 AND P3HR-1, were compared by partial denturation mapping. B95-8 viral DNA showed a homogeneous denaturation pattern. In contrast, P3HR-1 viral DNA was heterogeneous, containing at least two classes of molecules, classified into groups A a... | 211,256 | [
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0.2245515,
0.1657792,
0.02602697,
0.19... |
Neutralising antibodies to parainfluenza 3 virus in African wildlife, with special reference to the Cape buffalo (Syncerus caffer). | As part of a study to assess the prevalence of common viral agents in African wildlife, nearly 3,300 sera from 44 different wild species, from eight African countries, have been examined for neutralising antibodies to parainfluenza 3 (PI3) virus. Antibody was demonstrated in 20 of the 44 species examined, including sev... | 211,274 | [
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0.17581,
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0.1818348,
0.02538653,
0.2723363,
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... |
Effects of several monoamine-related compounds on the reserpine-induced spikes recorded from the medial nucleus trapezoides in rabbits. | Effects of several monoamine-related compounds on the reserpine-induced spikes recoreded from the medial nucleus Trapezoides (reserpine-induced Tr spikes) in rabbits were investigated. 5HTP (30--50 mg/kg, i.p.) showed marked suppression of reserpine-induced Tr spikes. Parachlorophenylalanine (PCPA) alone induced spikes... | 211,305 | [
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... |
[Deposits of immunoglobulins in the cells of chronic lymphocytic leukemia (author's transl)]. | Cristalloid inclusions were demonstrated in the perinuclear space and the ergastoplasm of cells of chronic lymphocytic leukemia. These inclusions and the immunoglobulins of the cell membrane consisted of IgG. The leukemic cells were able to synthesize, but not to secrete, monoclonal immunoglobulins. | 211,311 | [
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0.... |
Uptake and release of norepinephrine by slices of rat cerebral cortex: effect of agents that increase cyclic AMP levels. | Cerebral cortical slices from rats were incubated in physiologic saline, and the uptake, release, and K+-stimulated release of norepinephrine were measured. Dibutyryl cyclic AMP, the phosphodiesterase inhibitors aminophylline and papaverine, and adenosine (which stimulates adenyl cyclase) all caused a variable increase... | 211,464 | [
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0.000438862,
0.1987731,
0.1895897,
0.1084161,
0.0023151... |
Glycoproteins from the aorta. | This review deals with the data on isolation techniques, structure, physicochemical properties and biological function of glycoproteins isolated from the aorta. Some glycoproteins extracted at low ionic strengths (soluble glycoproteins) are immunologically distinct from serum glycoproteins. The designation "structural ... | 211,475 | [
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... |
Fused rocket and rocket immunoelectrophoresis adapted for demonstration and quantitation of the A antigen of Marek's disease virus-infected cell cultures. | Preliminary results have shown that the rocket immunoelectrophoresis technique can be used as a method for quantitation of the A antigen of Marek's Disease virus-infected cell cultures. | 211,484 | [
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Isolation of an avian erythrocyte protein possessing ADP-ribosyltransferase activity and capable of activating adenylate cyclase. | An ADP-ribosyltransferase was purified approximately 500-fold from the supernatant fraction of turkey erythrocytes. The enzyme hydrolyzed [carbonyl-(14)C]NAD to ADP-ribose and [carbonyl-(14)C]nicotinamide at a low rate. Nicotinamide formation from NAD was enhanced by arginine methyl ester > D-arginine approximately ... | 211,502 | [
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0.2485199,
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0.0... |
Angiotensin-converting enzyme and lysozyme in silicosis and asbestosis. | Serum angiotensin-converting enzyme (ACE) activity and lysozyme (LZM) concentration in 22 silicosis and 18 asbestosis patients were studied. These patients were compared with 57 untreated and 36 treated sarcoidosis patients. In all groups significantly raised ACE and LZM mean values were noted. Untreated sarcoidosis pa... | 211,579 | [
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... |
[Anti hepatitis A antibodies in the French population and in polyvalent plasma immunoglobulins at a transfusion center (Gamma TS)]. | A search for antibodies directed specifically against hepatitis virus A was carried out in 600 blood donors in the Paris region (354 men and 246 women) by a radio-immunological technic in solid phase. 75.3% had a positive test, no difference was found as regards sex on country of origin (57 were not French). An increas... | 211,590 | [
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0.3613205,
0.1748293,
0.07115342,
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0... |
[Duality of dopaminergic receptors. Pharmacologic and clinical perspectives]. | A univocal disorder of dopaminergic activity in the nerve structures responsible for extra-pyramidal motility does not take into account the total phenomena seen in psychomotor neurological studies. The hypothesis of two categories of dopaminergic receptors-respectively excitatory (DA) and inhibitory (DAi)--in the stri... | 211,603 | [
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0.001791018,
0.01683633,
0.08408703,
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[Sinus node dysfunction with conduction disorders and lithium poisoning]. | A case of lithium poisoning with lithium salts in a man of 66 years is reported. Sinus node dysfunction and conduction-tissue modifications were found. The responsibility of lithium in these disoredrs is discussed. The literature and the cellular mode of action of lithium are reviewed. | 211,626 | [
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... |
Surgical management of Cushing's syndrome. | Twenty-seven operations for Cushing's syndrome were reviewed. Included were five cases of adenoma and 22 of adrenal cortical hyperplasia. Preoperative laboratory data, particularly the metyrapone test, were highly accurate in distinguishing adenoma from hyperplasia. Bilateral flank incisions are preferable to the trans... | 211,656 | [
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0.1023747,
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0.00401085,
... |
Possible role of initiation factor activity in the action of interferon. | Treatment of mouse L cells with homologous interferon results in the production of a protein which inhibits initiation factor activity. Characterization experiments indicate that the interferon in the preparation is responsible for the induction of an inhibitor protein. The impairment of initiation factor activity indu... | 211,662 | [
-0.04908332,
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0.56023,
0.2196682,
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0... |
Effect of interferon on togavirus and arenavirus infections of animals. | The sensitivity of togaviruses to the effects of IF appears to permit successful exploitation of IF inducers, whereas the relative insensitivity of arenaviruses to IF in vitro appears to correlate with the complete lack of success of poly (ICLC) therapy in the monkey model. Noteworthy is the successful use of poly (ICL... | 211,667 | [
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0.4531176,
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0.09086914,
0.04460032... |
Effect of interferon respiratory infections of animals. | Several animal models are available for the evaluation of interferon in respiratory virus infections. Considerable variability exists among the respiratory viruses with respect to sensitivity to exogenous interferon or induced endogenous interferon. Due to this apparent variability, combinations of interferon with immu... | 211,668 | [
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0.3168578,
0.06893265,
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[Enzymatic and ultrastructural changes in isolated liver mitochondria from mice infected with several group A arboviruses]. | Inoculation of white mice of varying body mass with pathologic strains of eastern and Venezuelan equine encephalomyelitis viruses and their attenuated variants (DNC-20/6 and No. 2621), promising as vaccine candidates, resulted in an increase of enzymatic activity and ultrastructural changes of isolated mitochondria fro... | 211,733 | [
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0.3199494,
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0.05960247,
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[Inactivation of viruses in water by anodic oxidation (author's transl)]. | The inactivating effect of anodic oxidation on viruses performed in an experimental electrolytic polarization unit was investigated with 11 different viruses suspended in tap and superficial water. Furthermore attempts were made to define the influence of factors important in experimental and water respect. Using conce... | 211,753 | [
-0.2169116,
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0.1037662,
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[Experimental study of cellular immunity after administration of inactivated and live virus vaccine]. | Experiments were conducted on guinea pigs with the use of cell migration inhibition test of the peritoneal exudate; stimulation of a definite level of cell immunity in response to the administration of both live and of inactivated vaccine virus was shown. The results obtained are used for the interpretation of the acti... | 211,759 | [
-0.004615499,
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0.5184086,
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0.06399903,
0.000... |
Ultrastructural localization of rabies virus antigens in infected trigeminal ganglion of hamsters. | The trigeminal ganglion of hamsters infected with CVS strain of rabies virus was investigated by electron microscopy with peroxidase-labeled antibody. Major localization of virus antigens were the following three types of structures; rabies virion, cytoplasmic inclusion, and ribosomal granules consisting of Nissl body.... | 211,787 | [
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The isozyme pattern of cyclic AMP-dependent protein kinase and the distribution of a cervicovaginal antigen in experimental carcinoma of the cervix uteri of mice. | Tissue-sections from 12 methylcholanthrene-induced carcinomas of the cervix uteri of mice were tested for the presence of an antigen normally confined to the cervicovaginal epithelium. The antigen was detected in 10 of the 12 tumours investigated with indirect immunofluorescence, and in all 7 tumours studied with the m... | 211,793 | [
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-... |
Retardation of brain myelination by malnourishment and feeding low protein irradiated diet in rats. | The effect of feeding low protein diet, and the low protein irradiated diet on the deposition of myelin in the brains of rats over two generations showed that malnourishment lowered the CNP enzyme activity when compared to the normal (high protein) diet fed control rats during early postnatal period. Irradiated low pro... | 211,823 | [
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0... |
Müllerian adenosarcoma of the uterus. Ultrastructure before and after radiation therapy. | A case of müllerian adenosarcoma arising in the endometrium was studied by light and electron microscopy before and after radiation treatment. The tumor was composed of malignant stroma containing undifferentiated mesenchymal cells admixed with mature fibroblasts and other cell that contained crystalloids. The surface ... | 211,843 | [
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0.02110352,
... |
Secretory antibodies against turkey coronaviral enteritis. | Studies on local immunity to transmissible coronaviral enteritis of turkeys (bluecomb) was made. Intestinal secretions and bile from affected birds contained secretory immunoglobulins against coronaviral antigen throughout the 6 months' duration of the experiment. Attempts to purify and to characterize the globulins in... | 211,889 | [
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0.02291751,
0.03561893... |
Mortality after long exposure to cummingtonite-grunerite. | Ore containing cummingtonite-grunerite has been mined to extract gold since 1876 in Lead, South Dakota. Each of the 1,321 men who were recorded as having worked 21 years or more with the Homestake Mine was allocated to one of 5 dust-exposure categories on the basis of work history and available information on environme... | 211,890 | [
-0.1358309,
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0.5607836,
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... |
Survey of human virus occurrence in wastewater-recharged groundwater on Long Island. | Treated wastewater effluents and groundwater observation wells from three sewage recharge installations located on Long Island were assayed on a monthly basis for indigenous human enteroviruses and coliform bacteria for a period of 1 year. Viruses were detected in groundwater at sites where recharge basins were located... | 211,935 | [
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0.049514... |
[Instability of the DNA content in Entamoeba histolytica]. | DNA content was repeatedly determined during a 10-month period on axenically cultured tropho-zoites from three strains (HK-9:NIH, HM-2:IMSS and HM-3:IMSS) and a clone of HK-9:NIH strain of Entamoeba histolytica, by means of the diphenylamine reaction. Average DNA content was more or less variable in all of them. Accord... | 211,941 | [
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-0.04004231,
-0.2307996,... |
[Phagocytosis of human erythrocytes by Entamoeba histolytica. Quantitative study]. | The degree of eythrophagocytosis of two recently isolated strains of E. histolytica was measured by microscopic examination. Amebas isolated from a patient with amebic rectocolitis (strain HM22:IMSS, monoxenic) ingested human red blood cells faster and in larger numbers than trophozoites isolated from an asymptomatic c... | 211,953 | [
-0.05640722,
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0.3394864,
0.1... |
Production of cecal lesions in newborn guinea pigs with axenically cultivated Entamoeba histolytica. | The production of cecal lesions with axenically cultivated Entamoeba histolytica in an experimental animal is reported for the first time. Forty-three newborn guinea pigs (one to five days old) were inoculated via laparatomy with 2.5 x 10(5) to 2 x 10(6) strain HM-1-IMSS amebae. Of 23 animals surviving to the 7th posti... | 211,954 | [
-0.0613506,
-0.8100003,
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0.4098917,
0.3974614,
-0.1725... |
Restoration of virulence of axenically-cultivated Entamoeba histolytica by cholesterol. | The lost pathogenicity of two strains of Entamoeba histolytica, one isolated in 1924 and the other in 1967, grown in axenic culture for the past five and six years respectively, was restored by supplementing the culture medium with cholesterol through a number of transfers. The number of passages in the cholesterol sup... | 211,958 | [
-0.3589165,
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0.1184439,
0.1030947,
0.3820416,
-0.05182475,... |
[Activity of the alternative complement pathway by various axenic strains of Entamoeba histolytica]. | The activation of the alternative pathway of complement by axenic cultures of E. histolytica is reported. The activation is carried out in different proportions by several axenic strains, i.e., HK9:NIH, HM1:IMSS, HM2:IMSS and HM3:IMSS; the end result consists of a destruction of the parasite as well as consumption of t... | 211,963 | [
-0.2604046,
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0.05951728,
0.4702744,
0.1351149,
-0.0867198... |
[A new hemagglutination method to determine antibodies against Entamoeba histolytica]. | A passive hemagglutination method useful for the determination of antibodies against Entamoeba histolytica is described. The E. histolytica antigen is attached to group "O" human red blood cells by means of CrCl3. The specificity and sensitivity of the CrCl3 method was compared with other hemagglutination methods, i.e.... | 211,969 | [
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0.009796858,
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0.1163794,
0.3618825,
0.09919295,
-0.1760618... |
Interaction of aflatoxin with infectious bursal disease virus infection in young chickens. | Young White Leghorn chickens fed 2.5 microgram of aflatoxin (Afl) per g of diet from hatching until 4 weeks old and infected with infectious bursal disease virus (IBDV) at 3 weeks old had significantly higher mortality and more severely depressed body weights than chicks with aflatoxicosis or IBD alone. Afl-IBDV chicks... | 212,001 | [
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0.2327748,
0.1415526,
0.2305798,
-0.2504001... |
Rhinotracheitis in turkey poults. | A severe upper respiratory disease of young turkeys is described that resulted in high morbidity and mortality. Death was due to asphyxiation produced by occlusion of the trachea or nostrils. The postmortem lesions were tracheitis, pulmonary edema, swollen livers and spleens, and a drastic reduction in bursa size. Burs... | 212,006 | [
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-0.02730626,
-0.09044745,
0.07139078,
0.06662377,
0.2084964,
-0.009... |
Properties of mitochondria isolated from cyanide-sensitive and cyanide-stimulated cultures of Acanthamoeba castellanii. | 1. Mitochondria isolated from cultures of Acanthamoeba castellanii exhibit respiratory control and oxidize alpha-oxoglutarate, succinate and NADH with ADP:O ratios of about 2.4, 1.4 and 1.25 respectively. 2. Mitochondria from cultures of which the respiration was stimulated up to 50% by 1mm-cyanide (type-A mitochondria... | 212,020 | [
-0.3134083,
-0.2342642,
-0.005042376,
-0.06520148,
-0.02308647,
0.1822755,
0.04510349,
-0.1223277,
-0.1428602,
-0.127193,
-0.1247543,
0.2723856,
-0.03741781,
0.2853196,
-0.6958189,
0.1361124,
-0.4881837,
0.341323,
-0.3162354,
0.2270808,
0.5137339,
0.09920818,
0.3363518,
... |
Properties of a cytochrome c-enriched light particulate fraction isolated from the photosynthetic bacterium Rhodopseudomonas spheroides. | Differential centrifugation of suspensions of French-press-disrupted Rhodopseudomonas spheroides yielded a light particulate fraction that was different in many properties from the bulk membrane fraction. It was enriched in cytochrome c and had a low cytochrome b content. When prepared from photosynthetically grown cel... | 212,023 | [
-0.2234942,
0.06433959,
0.08040666,
0.2244358,
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-0.1991676,
0.01479075,
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0.3052965,
0.2467413,
0.07946738,
0.003659937,
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0.02829632,
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0.03849997,
-0.7407973,
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0.06420093,
0.1045129,
0.5933141,
0.3055828,
0.2338067,
... |
Studies with primaquine in vitro: superoxide radical formation and oxidation of haemoglobin. | 1. The production of superoxide radicals from primaquine diphosphate in aqueous solution has been demonstrated, using as indicator the reduction of cytochrome C with inhibition of the reaction by superoxide dismutase. 2. Primaquine-mediated oxidation of haemoglobin to methaemoglobin was reduced by the addition of catal... | 212,091 | [
-0.2212549,
0.1124032,
-0.2576118,
0.01653871,
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0.03573255,
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0.04519479,
0.3629355,
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0.3017308,
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0.2152245,
-0.07787718,
0.3525151,
0.2246086,
-0.04405245,
0.1306895,... |
In vitro translation of nematode cuticular collagens. | Phenanthroline treatment of growing cultures of the free-living nematode Panagrellus silusiae was used to lower the degree of hydroxylation of nascent collagen chains at the polysomal level. Under these conditions, the bound pentasome-hexasome fraction provided substrate for prolyl hydroxylase. When this polysomal frac... | 212,107 | [
-0.135393,
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0.03390435,
0.06935824,
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0.1292596,
0.2662832,
0.4115713,
0.3032891,
0.08601284,
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0.01061282,
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0.07183753,
0.3088394,
-0.3345567,
0.1011375,
-0.2271371,
-0.05108285,
0.5617321,
0.1860219,
-0.1871607,
0... |
[ESR study of the superslow diffusion of lysozyme macroradicals in an aqueous matrix]. | Using kinetic data on recombination macroradicals in freezed water solutions of lyzozyme, superslow molecular motions of biopolymer have been studied. Recombination of macroradicals is observed at 160--240 K and it has a stepwise character. The kinetic data are described quantitatively by the model, in which the set of... | 212,112 | [
0.05028138,
-0.1746138,
-0.3262947,
0.1013109,
-0.06520211,
-0.422384,
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0.07617246,
-0.01289844,
0.1186833,
0.3256984,
0.4255342,
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-0.5959048,
-0.2502625,
-0.1241783,
0.3319018,
0.5190302,
-0.225905,
-0.0860446,
... |
[Polypeptide synthetase activity of chromatin from eukaryotic cells]. | It is shown that the polypeptide synthetase activity (PS-activity) of chromatin from rat liver is increased 9--21 hrs after partial hepatectomy. Among 9 amino acids studied alanine, methionine, lysine, tyrosine and arginine are not incorporated into the system in question. The highest rate of polymerization is observed... | 212,128 | [
0.3490042,
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0.1579233,
0.1384764,
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0.1247003,
0.09769703,
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0.4609768,
0.01728502,
0.04620941,
0.0250531,
0.1642739,
-0.6097766,
-0.111407,
-0.5055071,
0.1605826,
-0.03182017,
0.5278381,
0.6661456,
0.08062243,
-0.1702438,
0... |
The benzodiazepine receptor in normal and pathological human brain. | Benzodiazepines bind with high affinity to a specific benzodiazepine receptor, which occurs exclusively in the central nervous system. The affinity of various benzodiazepines to the receptor closely parallels their pharmacological and therapeutic potency. Binding to the receptor is stereospecific. The receptor is mainl... | 212,153 | [
0.07855846,
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0.110345,
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0.2997662,
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-0.2212714,
0.2088847,
0.09154984,
0.1982484,
0.1006088,
0.3197127,
-0.04018004,
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-0.4543373,
0.3209554,
0.05024024,
0.1039052,
0.2260412,
0.1619675,
0.08892236,
-0.3... |
Inhibition of spermiation in the Syrian hamster using dibutyryl cyclic-AMP. | Young adult male Syrian hamsters were given intraperitoneal injections of 50 mg dibutyryl cyclic AMP twice daily for a period of three days. On the fourth day the animals were sacrificed and their testes were processed for light and electron microscopy. The results indicate that the mature spermatozoa were retained wit... | 212,195 | [
-0.03851269,
0.05981148,
-0.2018982,
-0.2480563,
0.3392999,
-0.2597905,
-0.3265356,
-0.009349606,
0.2702081,
0.07558496,
0.01565327,
0.05113484,
-0.1420264,
0.1127941,
-0.2592555,
-0.0462945,
-0.4368905,
-0.1761628,
-0.1924473,
-0.3211564,
0.4577934,
0.2972399,
-0.0138764... |
Specific binding proteins for cyclic AMP and cyclic GMP in Dictyostelium discoideum. | In Dictyostelium discoideum both cyclic AMP and cyclic GMP are regulated by chemotactic stimuli. Binding proteins specific for cAMP and cGMP have been found in aggregation competent cells as well as in cells harvested during growth. The activity of binding proteins was, on the average, lower in the growth phase cells. ... | 212,206 | [
-0.210638,
-0.2190411,
-0.0537127,
-0.4569166,
-0.0772481,
-0.02145678,
-0.1286603,
0.19684,
0.07577257,
0.1451012,
-0.06820139,
-0.03903485,
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0.0113826,
-0.4849047,
0.05349542,
-0.564586,
0.1252284,
0.05072557,
0.3523167,
0.6577102,
0.2517274,
-0.0653389,
0.... |
Mode of action of peptide hormones. | The mode of action is discussed of the peptide hormones which trigger neosynthesis of a specific product in their target cells without being involved in any release step. Particular attention is paid to the early events elicited by ACTH in isolated adrenocortical cells. It is shown that extracellular calcium ions at ph... | 212,229 | [
-0.3049307,
-0.2828733,
-0.3617323,
-0.02908088,
0.07103359,
-0.2158734,
-0.1461326,
0.2200241,
0.2026918,
0.374472,
-0.1551964,
-0.1208093,
0.09173705,
-0.2417775,
-0.4650484,
-0.03117079,
-0.2851191,
-0.1259755,
-0.02497877,
0.1100401,
0.5165061,
0.1869393,
-0.08702219,... |
On the metabolism of two adrenocorticotrophin analogues. | The metabolism of Synacthen (corticotrophin-(1--24)-tetracosapeptide) and C-41795-Ba ([D-Ser1,Lys17,Lys18]-corticotrophin-(1--18)-octadecapeptide amide) have been compared in the rat following intravenous injection. Using Synacthen and C-41795-Ba labelled with tritium it was possible to follow the tissue distribution o... | 212,234 | [
-0.09785493,
0.0746534,
-0.5198494,
-0.01047128,
0.1496962,
-0.2377621,
-0.1443462,
0.0391123,
0.01467648,
0.2423796,
-0.2707773,
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0.0494331,
-0.09175035,
-0.5293454,
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-0.4438981,
0.1365687,
0.4665124,
0.7229341,
0.3558004,
0.5805253,
-0.09637728,
... |
Multiple granular-cell tumors of the ascending colon: microscopic study. | Light and electron microscopic study of a case of multiple granular-cell tumor of the ascending colon is presented, and the relevant medical literature is reviewed. It seems that the biologic behavior of this tumor in the colon does not differ from that in other locations. Histologically, a few granular cells are seen ... | 212,256 | [
-0.111826,
-0.3055474,
-0.3952098,
-0.2222381,
-0.05980061,
-0.2189509,
-0.1745084,
-0.02413326,
0.007974408,
0.1158092,
-0.04913976,
0.03476411,
0.09988825,
-0.1212224,
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0.1401011,
-0.4840386,
-0.2405582,
0.1270086,
0.09922958,
0.4999266,
0.1148818,
0.0676192... |
Changes in the activity of hydrolytic enzymes in the brain of rats intoxicated by ethyl-mercury-p-toluene-sulfanilide. | A histochemical study concerning the activity of phosphatases and esterases of the brain has been undertaken in rats experimentally intoxicated by the fungicide ethyl-mercury-p-toluenesulfanilide (EMTS). The results have shown that compared with other mercury compounds, both organic and inorganic ones, such as corrosiv... | 212,352 | [
-0.08101594,
-0.1251448,
0.1629703,
-0.07428098,
-0.2800759,
-0.3378587,
-0.2526753,
-0.08901415,
-0.1320379,
0.4351661,
0.09849439,
0.459038,
0.1655778,
0.09270298,
-0.1735239,
0.5671868,
-0.3230681,
-0.01250502,
-0.0443282,
0.355767,
0.01234928,
0.06985861,
-0.09629315,... |
Effects of epinephrine, indomethacin, acetylsalicyclic acid, dexamethasone, and cyclic AMP on the in vitro activity of lysosomal hyaluronidase from the rabbit iris. | The effects of epinephrine, indomethacin, acetylsalicylic acid, dexamethasone, and cyclic AMP on lysosomal hyaluronidase activity in in the rabbit iris were studied in vitro. Indomethacin and acetylsalicylic acid inhibited the lysosomal hyaluronidase activity. Dexamethasone and cyclic AMP (adenosine-3',5'-cyclic monoph... | 212,383 | [
-0.1150559,
-0.1508363,
-0.2289861,
0.01320974,
0.09585501,
-0.2590515,
-0.1281545,
0.1266801,
-0.03213282,
-0.05427349,
0.1083959,
0.02099289,
0.09547551,
-0.05512015,
-0.3286245,
0.4237437,
-0.4888648,
-0.1196321,
-0.02585979,
0.05281732,
0.5340436,
-0.01335479,
-0.1421... |
Wescodyne: lack of activity against poliovirus in the presence of organic matter. | The National Institute of Health Guidelines for Recombinant DNA Research recommends 2% aqueous Wescodyne, an iodophore that is used in many hospitals and laboratories as a disinfectant, as a decontaminant for biological safety cabinets and 5% for a spill outside a cabinet. A contact time of 10 to 15 minutes was given f... | 212,387 | [
-0.6043932,
-0.1974964,
-0.04880824,
-0.1917925,
0.1958083,
-0.06297991,
-0.2790968,
0.1908788,
0.147102,
0.1304946,
0.03824193,
0.3515352,
-0.02671117,
0.1674378,
-0.08905328,
-0.07115088,
-0.5379286,
-0.09441736,
0.08976705,
0.2925659,
0.05191084,
0.3699932,
-0.00175515... |
An organ culture model for study of biochemical development of fetal rat lung. | We have developed a short-term organ culture model for the study of the biochemical and morphological development of late gestation fetal rat lung. Explants (1 mm3) of 19-day lung were cultured in an oxygen enriched environment in the presence of synthetic serum-free medium for 3 days. Morphological maturation continue... | 212,389 | [
0.148037,
-0.3818706,
-0.444413,
-0.06334172,
0.08885219,
0.004485948,
-0.2443613,
0.3208187,
-0.009119911,
-0.09388302,
-0.1000312,
0.1052583,
-0.1351458,
0.04539371,
-0.1847995,
-0.02029073,
-0.2784805,
0.08293623,
-0.115224,
0.357277,
0.3045814,
0.3309942,
-0.1665473,
... |
Decrease of rat liver cysteine dioxygenase (cysteine oxidase) activity mediated by glucagon. | The hepatic cysteine dioxygenase activity of rats was markedly decreased by the intraperitoneal administration of glucagon. The enzyme activity was also decreased by either dibutyryl cyclic AMP or theophylline. The prior administration of actinomycin D completely blocked the glucagon-mediated decrease of enzyme activit... | 212,416 | [
0.08132801,
-0.1695787,
-0.1911929,
0.2247259,
0.1530725,
0.01216283,
-0.06159185,
-0.03519291,
0.04378302,
0.09732918,
0.08341175,
0.01214864,
0.0353604,
0.161718,
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0.1531809,
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-0.1868636,
-0.08491149,
0.1572056,
0.01159763,
0.2532656,
-0.03014937,... |
Rickettsial indirect hemagglutination test: isolation of erythrocyte-sensitizing substance. | The erythrocyte-sensitizing substances (ESS) of Rickettsia prowazekii and R. conorii were characterized by biological and chemical criteria. ESS could be derived from either soluble or particulate complement-fixing antigens obtained by ether extraction of rickettsiae. The soluble complement-fixing antigen exhibited two... | 212,448 | [
0.09405248,
0.2301826,
0.02942831,
0.09794917,
-0.1597091,
-0.169782,
-0.1836232,
0.1480708,
0.1658335,
-0.03449408,
0.1538457,
-0.06759205,
0.03539848,
0.2461663,
-0.08980588,
-0.04780503,
-0.4329973,
-0.007620987,
0.05033988,
0.1668965,
-0.2417858,
-0.0515779,
-0.096382... |
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