title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Evaluation of otic drops on infection and healing of traumatic tympanic membrane perforations. | Guinea pigs were used to compare the efficacy of three commercially available otic preparations in treating traumatic tympanic membrane perforations. The results suggest that a clear, viscous solution of low pH will significantly reduce the incidence of infection and will not retard subsequent membrane healing. | 221,762 | [
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Effect of diabetes and fasting on the uridine triphosphate content and uridine kinase activity of rat cardiac and skeletal muscle. | The influence of diabetes and starvation on uracil nucleotide metabolism in muscle was studied. It was found that the uridine triphosphate (UTP) content of heart and diaphragm muscle was decreased in fasted and streptozotocin-diabetic rats and that insulin treatment of diabetic animals restored the UTP concentration to... | 221,781 | [
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[Influence of dental caries prophylaxis using fluor-vigantoletten 1000 on plasma fluoride levels in infants (author's transl)]. | A group of 57 newborns was divided into two: group I (27 subjects) received solely 1,000 I.U. vitamin D3 per day for 6 months, whereas group II (30 subjects) were given a combination of 1,000 I.U. vitamin D3 and 0.25 mg fluoride. At the end of the time of observation there was a significant difference between the plasm... | 221,804 | [
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Neuromuscular defect after suppression of ion conductance. | In rat skeletal muscle, trimetazidine (TMZ) caused a transmission defect without directly blocking binding of acetylcholine--ionophore impairment. In vivo, TMZ produced low-amplitude and cumulative depression of successive muscle responses, and immediate posttetanic exhaustion. These features differed from the effects ... | 221,854 | [
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Peripheral neuropathy in cerebrotendinous xanthomatosis. | Four patients with cerebrotendinous xanthomatosis (CTX) underwent electrophysiologic investigations, which demonstrated impairment in the functioning of the peripheral nerves in all four cases. The changes consisted of slow motor and sensory conduction. The changes were most marked in the older subjects, in whom the di... | 221,858 | [
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Protected deoxyribonucleoside-3' aryl phosphodiesters as key intermediates in polynucleotide synthesis. Construction of an icosanucleotide analogous to the sequence at the ends of Rous sarcoma virus 35S RNA. | Several modifications have been incorporated into the phosphotriester strategy for chemical synthesis of oligodeoxyribonucleotides. These include high-yield methods of preparation and isolation of O5', N-protected deoxyribonucleoside-3' p-chlorophenyl phosphates which serve as key intermediates, and the elimination of ... | 221,888 | [
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Expression of single copy DNA sequences in nuclear RNA from undifferentiated mouse embryonal carcinoma and differentiated muscle cell line. | Nuclear RNA from an undifferentiated mouse embryonal carcionma (EC) cell line and a differentiated muscle (Mt) cell line from similar origin has been analysed with respect to base sequence complexity and frequency distribution with different probes. With the single copy component of mouse genomic DNA it is shown that t... | 221,889 | [
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Specificity of memory cells raised against trinitrophenyl-conjugated syngeneic cells. | Exogenous lipid analogues can be incorporated into purified plasma membranes of EL4 tumor cells. When EL4 membranes are incubated with sonicated lipid vesicles containing spin-labeled phosphatidylcholine and then purified, they exhibit paramagnetic resonance spectra characteristic of spin labels dilutely dispersed in t... | 221,897 | [
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Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). | Neoplastic transformation of cell by avian sarcoma virus is mediated by a single viral gene (src), which encodes a phosphoprotein (pp60src) with the enzymatic activity of a protein kinase. The DNAs of vertebrate species contain a highly conserved homologue of src that is also represented in the polysomal RNA of uninfec... | 221,907 | [
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Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc. | Competitive binding assays have demonstrated that a cholesterol-induced canine lipoprotein containing only the E apoprotein (apo-E HDL(c)) binds to the same cell surface receptors of human fibroblasts as human low density lipoproteins (LDL). However, the apo-E HDL(c) have a much greater binding activity than LDL. Equil... | 221,921 | [
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Biochemical basis for differential deoxyadenosine toxicity to T and B lymphoblasts: role for 5'-nucleotidase. | Deoxyadenosine metabolism was investigated in cultured human cells to elucidate the biochemical basis for the sensitivity of T lymphoblasts and the resistance of B lymphoblasts to deoxyadenosine toxicity. T lymphoblasts have a 20-to 45-fold greater capacity to synthesize deoxyadenosine nucleotides than B lymphoblasts a... | 221,924 | [
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Nonimpulse-mediated synaptic transmission during the generation of a cyclic motor program. | A small neuronal network in the lobster stomatogastric ganglion, composed of impulse-producing motor neurons, gives rise to cyclic patterned outputs. This network continues to generate its cyclic motor program if impulse production within the ganglion is blocked. Continuously graded, nonimpulse-mediated, chemical synap... | 221,982 | [
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Pituitary hormones in brain: where, how, and why? | Peptide and protein hormones usually considered as being of pituitary origin have been detected within the central nervous system by means of radioimmunoassay, bioassay, and immunocytochemical techniques. Intracerebral administration of some of these hormones or fragments thereof elicit behavioral responses, suggesting... | 221,983 | [
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Computerized tomography of coagulation necrosis of the brain and brain tumors. | Diffuse contrast enhancement was observed on computerized tomography (CT) of coagulation necrosis of the brain and brain tumor. CT scans of delayed radiation necrosis of the brain seen in two patients showed a low absorption that was diffusely enhanced after an intravenous injection of contrast medium. Areas of central... | 221,999 | [
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[Biochemical changes in the adrenals and their function in mechanical trauma]. | Concentration of corticosterene, activities of succinate dehydrogenase and cytochrome oxidase, contents of ascorbic acid, reduced glutathione, free amino acids, RNA and DNA were studied in rat and rabbit adrenal glands within 10 min, 5, 10 and 24 hrs after crushing of the soft tissues of posterior extremities under con... | 222,068 | [
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[Molecular mechanisms of hypothalamic hexapeptide regulation of the links in glycogen metabolism]. | Alterations in content of glycogen as well as in activity of phosphorylase and phosphoprotein phosphatase were studied in various rat tissues after intravenous administration of a new hypothalamic hexapeptide Tyr-Gly-Leu-Pro-Gly-NH2. An increase in phosphoprotein phosphatase activity was observed in heart muscle, which... | 222,071 | [
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Plasma catecholamines, cyclic AMP and metabolic substrates in hemorrhagic shock of the rat. The effect of adrenal demedullation and 6-OH-dopamine treatment. | Plasma catecholamines, cyclic AMP and metabolic substrates in hemorrhagic shock of rats was studied in 4 groups of animals: 1) Control rats, 2) rats with adrenal demedullation, 3) rats with 6-OH-dopamine induced chemical sympathectomy, and 4) rats with combined demedullation and sympathectomy. The rats were bled to a s... | 222,118 | [
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Granular cell tumor of the common bile duct. Case report and review of literature. | A case of granular cell tumor is reported and the main features of the previously reported cases are summarized. This lesion usually presents in a black woman as a small tumor obstructing the common bile duct and resulting in cholecystitis and/or obstructive jaundice. The cell of origin is still disputed. Local resecti... | 222,132 | [
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Rhegmatogenous retinal detachment complicating cytomegalovirus retinitis. | Six eyes in four patients with cytomegalovirus retinitis developed retinal holes and retinal detachment. Holes appeared in areas of necrosis and were typically large and round with shaggy edges. Differentiation from exudative detachment was sometimes difficult because of obscuration of the fundus by vitreous haze. Cryo... | 222,149 | [
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Immunologic dysfunction among PBB-exposed Michigan dairy farmers. | In 1973 inadvertent contamination occurred in a special farm feed supplement for lactating cows. Polybrominated biphenyls (PBBs) were used in place of magnesium oxide resulting in serious harm to farm animals, including cattle, chickens, geese, ducks. Farm families, accustomed to eating their own products, were most he... | 222,196 | [
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Bronchioloalveolar cell carcinoma of the lung: a clinicopathological study. | Thirty-nine patients with bronchioloalveolar carcinoma were reviewed. The primary lung tumor from 27 patients was examined and divided by histological criteria into three categories. The type 1 pattern was associated with a mean survival of 4.7 years. A mean survival of 3.8 years was attained in patients with type 2. P... | 222,223 | [
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[Stress and immunity in cattle]. | Stress of variable length may be caused in calf by parenteral administration of supercortisol and application of acute thermal load. Hormonal or thermal stress may have negative impact on postvaccinal immunity to paratyphoid (Salmonella dublin 81), as may be interpreted with reference to the O-agglutination titre of bl... | 222,226 | [
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Asymptomatic infection of mouse hepatitis virus in the rat. Brief report. | After intranasal inoculation of suckling rats mouse hepatitis virus multiplied mostly in the nasal epithelium; though there were no symptoms, antibodies were produced. Antibodies were also demonstrated in adult rats. These findings suggest that the rat may be a natural host for the virus. | 222,242 | [
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Antibody-dependent cell-mediated cytotoxicity (ADCC) in Aujeszky's disease. | Antibody-dependent cell-mediated cytotoxicity (ADCC) was studied using as targets 51Cr-labelled Vero cells infected with the Bartha strain of Aujeszky's disease virus (ADV). Using hyperimmune anti-ADV serum to sensitize the targets, porcine leukocytes from dextran-sedimented blood were found to be efficient effector ce... | 222,244 | [
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Viral nucleic acid synthesis in HSV infected neural cells. | HSV-1 replication and synthesis of viral DNA and RNA have been examined in gliomas of human (COX) and rat origin (C6) and in mouse neuroblastomas (D2). COX cells fully support HSV-1 replication and show patterns of viral DNA and RNA synthesis similar to those seen in continuous line cells. HSV-1 also grows to high tite... | 222,245 | [
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Cyclic AMP induces the synthesis of developmentally regulated plasma membrane proteins in Dictyostelium. | Dictyostelium discoideum slugs (pseudoplasmodia) were disaggregated and the resynthesis of developmentally regulated plasma membrane proteins examined. The synthesis of the majority of these proteins was inhibited when cells were overlaid with Cellophane and maintained as a monolayer. However, cell contact and movement... | 222,314 | [
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Ethanediol monoester hydrolysis by monoacylglycerol lipase of rat liver microsomes. | The hydrolysis of long-chain monoester of ethanediol by rat,liver subcellular fractions was investigated in order to define the carboxylic acid ester hydrolase involved and to localize the enzymic activity. We found that with 1-O-hexadecanoyl [U-14C]ethanediol as substrate, hydrolytic activity was foremost associated w... | 222,330 | [
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An analysis of some factors influencing alpha-adrenoceptor feed-back at the sympathetic junction in the rat heart. | 1 The effects of the selective prejunctional alpha-adrenoceptor antagonist, yohimbine, on the cardioacceleration responses to sympathetic stimulation were examined in the pithed rat. 2 Yohimbine reversed the inhibitory effects of the alpha-adrenoceptor agonist, clonidine, on the stimulation-induced tachycardia. 3 Yohim... | 222,385 | [
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-0.2214965,
-0.06962173,
-0.190016,
-0.1771773,
0.04183409,
-0.0270026,
-0.2828516,
0.1201968,
0.01219897,
-0.5530151,
-0.1271048,
-0.5096499,
0.03204628,
-0.1014051,
0.0244137,
0.393558,
0.1819966,
-0.1242937,
... |
The relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation. | The effect of varying calcium and magnesium concentrations was observed on the development of long-term potentiation (LTP) in the CA1 region of the rat hippocampus maintained in vitro. Treatments which would be expected to lower the depolarization-induced influx of calcium into neuronal elements (i.e. lowering Ca2+ or ... | 222,396 | [
-0.1034789,
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0.02752049,
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0.1398838,
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0.05972222,
0.1158241,
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0.136748,
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0.1569694,
0.2301922,
0.1806574,
0.05222103,... |
Abdominal crisis due to metastasizing lung carcinoma to the small bowel. | A rare case of small-bowel perforation due to metastasizing primary bronchogenic carcinoma is reported. A 64-year-old man presented with acute abdominal crisis from perforation of a metastatic focus in the wall of the small intestine. A 13-cm segment of small bowel, containing a firm mass which surrounded a 1.0 X 2.0-c... | 222,418 | [
-0.06150038,
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0.032259,
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0.01822557,
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0.3595336,
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0.2303926,
0.2985138,
-0.047847... |
Electron microscopic findings in primitive neuroectodermal tumors of the cerebrum. | The fine structure of 3 primitive neuroectodermal neoplasms of the cerebral hemispheres was studied. The predominant tumor cells were undifferentiated cells with prominent nuclei and scanty cytoplasm containing few organelles. Ultrastructural evidence suggesting differentiation into ependymal, neuronal and possibly ast... | 222,429 | [
-0.02374583,
0.05645596,
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0.1361612,
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0.3464402,
0.177176,
0.05921224,
... |
Localization of ACTH in the human hypothalamus. | Using an antiserum to porcine ACTH and the unlabeled antibody preoxidase-antiperoxidase technique, we have found that ACTH is present in neuronal cell bodies located exclusively in the arcuate nucleus of the human hypothalamus. ACTH-containing fibers are distributed extensively throughout the hypothalamus with a greate... | 222,452 | [
0.0647693,
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0.2574705,
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0.4234468,
0.1118938,
0.04653831,
0.2265042,
0.04138624,
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-... |
Hybrid pigment organelles in an invertebrate. | Observations of a number of vertebrate chromatophores have revealed the presence of more than one type of pigment organelles, suggesting that the different types are all derived from an equipotential organelle able to differentiate into any of the major pigment-containing organelles (Bagnara, 1972). Observations are pr... | 222,453 | [
0.1762283,
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0.05911143,
0.4210877,
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0.4511054,
0.02415818,
-0.05381321,
... |
Multiple 5' terminal cap structures in late polyoma virus RNA. | Nuclear and cytoplasmic polyoma virus-specific RNA extracted from 32P-labeled mouse embryo cells late during productive viral infection was analyzed for the presence of 5' terminal capped structures by complete digestion with RNAases T1, T2 and A, followed by two-dimensional electrophoretic fractionation. Seven major c... | 222,458 | [
-0.2889068,
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0.06575456,
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0.2169768,
0.3494931,
0.4748864,
0.39889,
0.03507003,
0.... |
Amplification in the leader sequence of late polyoma virus mRNAs. | Ribonuclease T1 fingerprints of the three "late" polyoma virus mRNAs show that oligonucleotides of the leader sequence are present in multiple copies in each mRNA. These oligonucleotides, however, appear unimolar in fingerprints of complete, continuous transcripts of the late strand of the viral DNA. Oligonucleotides w... | 222,459 | [
0.042759,
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0.236162,
0.03049816,
0.6379827,
0.06968385,
-0.3178859,
0... |
SV40 DNA injected into Xenopus oocyte nuclei is transcribed by RNA polymerase B. | SV40 DNA I. injected into Xenopus oocyte nuclei is transcribed. The SV40-specific RNA molecules migrate on sucrose gradients as do viral RNAs formed in infected green monkey cells but a variable proportion of RNA sequences complementary to SV40 DNA is also found in the light region of the gradients. All SV40-specific R... | 222,491 | [
-0.009072697,
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0.02577017,
0.5720997,
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... |
Human corticotropin (ACTH) radioimmunoassay with synthetic 1--24 ACTH. | A corticotropin antiserum was obtained from rabbits immunized with synthetic 1--24 corticotropin conjugated with bovine serum albumin. The antiserum did not cross react with synthetic alpha-melanotropin or with synthetic beta-endorphin and had a cross reactivity of 0.23% with human beta-lipotropin. We developed a radio... | 222,503 | [
-0.02502421,
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0.03002545,
0.315911,
0.2533553,
0.03851853,
-0.1477467,
... |
Triglyceride-poor very low density lipoprotein in human serum. | The chemical and physical properties of very low density lipoproteins, isolated from the pool of the sera of 60 persons with high pre-beta and normal triglyceride and cholesterol concentrations, have been studied. These very low density lipoproteins, a designated as triglyceride-poor very low density lipoproteins, cons... | 222,511 | [
0.01666175,
0.2160224,
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0.06451312,
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0.1046074,
0.02367077,
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0.06168923,
0.4634929,
0.2018333,
0.2959463,
-0.1036457,
... |
Polymorphonuclear leucocyte fluorescence and cryoglobulin phagocytosis in systemic lupus erythematosus. | Peripheral blood polymorphonuclear leucocytes (PMN) and cryoglobulins were isolated from patients with systemic lupus erythematosus (SLE). Fluorescent inclusions were found in PMN. Normal donor PMN were incubated with the sera and cryoglobulins from SLE patients. In most cases inclusions were observed after incubation.... | 222,518 | [
0.0863184,
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0.2238614,
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0.3955995,
0.2145476,
0.2482176,
-0.02003353,
... |
Bovine abortion associated with mixed Movar 33/63 type herpesvirus and bovine viral diarrhea virus infection. | A herpesvirus and cytopathogenic bovine viral diarrhea virus were isolated from a bovine fetus aborted in the 6th month of gestation. The herpesvirus was serologically indistinguishable from bovine herpesviruses DN-599 and Movar 33/63. | 222,535 | [
-0.09005336,
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0.1411307,
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0.05564458,
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0.0099612,
0.05487563,
... |
Cytochemistry of esterases. | Esterases are enzymes that cleave aliphatic and aromatic ester bonds. With the use of synthetic substrates, esterases can be demonstrated in hematopoietic cells. Using alpha naphthyl acetate or alpha naphthyl butyrate, nonspecific esterase activity can be demonstrated. Intense activity of nonspecific esterase that is i... | 222,537 | [
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0.248343,
0.06003463,
0.5971966,
0.1913112,
-0.02829534,
-0.273261... |
A kinetic analysis of the uptake of cytosine-beta-D-arabinoside by rat-B77 cells. Differentiation between transport and phosphorylation. | We present here a differentiation by kinetic methods of the tandem processes of transport and metabolic during uptake of cytosine-beta-D-arabinoside by intact rat fibroblasts. Transport across the cell membrane occurs by a carrier-mediated mechanism displaying a Km of approximately 500 microM and a V of approximately p... | 222,581 | [
-0.07330915,
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0.03729289,
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0.08585584,
0.5151958,
0.2694441,
-0.0008188785... |
The dolichol pathway of protein glycosylation in rat liver. Stimulation by GTP of the incorporation of N-acetylglucosamine in endogenous lipids and proteins of rough microsomes treated with pyrophosphate. | Incorporation of N-acetylglucosamine into endogenous lipid and protein acceptors was investigated on heavy microsomes from rat liver, incubated with UDP-N-acetyl[14C]glucosamine and GDP-mannose in the absence of detergent. This subcellular preparation derived for 95% or more from the rough endoplasmic reticulum and was... | 222,586 | [
-0.24328,
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0.09141731,
0.3910031,
0.3499804,
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0.06... |
Effects of monovalent cations on (Na+ + K+)-ATPase in rat brain slices. | The influence of monovalent cations on membrane (Na + K+)-ATPase was estimated in vitro in intact cells from the oxygen consumption of rat brain cortical slices. High concentrations of K+, Rb+ or Cs+ stimulated the respiration in the presence of Na+. This stimulation was antagonized by ouabain in a concentration- and t... | 222,599 | [
-0.1711203,
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0.04626719,
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0.3529389,
-0.08385628,
0.06083583... |
[Neural regulation of coronary circulation]. | In anesthetized dogs, with the aid of catheterization and perfusion of the coronary arteries roith heporinesed blood, catheterization of the heart cavities, and synchronous recording of the hemodynamics in unopened thorax, the mechanisms of neural regulation of the coronary circulation were analysed. Tonic effects of t... | 222,634 | [
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0.1294127,
... |
[Quantitative aspects of specific binding of cardiac glycosides to membrane receptors]. | Although the exact mechanism of positive inotropic action of cardiac glycosides is unknown, specific membrane bound proteins with high affinity for this group of drugs have been characterized. These "receptors" for cardiac glycosides have been measured quantitatively in cardiac tissue of humans and several species as w... | 222,657 | [
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0.06109742,
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0.1568741,
0.5423418,
0.01866783,
-0.2192715... |
Oligodactyly and multiple synostoses of the extremities: two cases in sibs. A variant of Cenani-Lenz syndactyly. | Two sibs with a rare phenotype of oligodactyly with metacarpal, carpal, radioulnar, and metatarsal synostoses and shortening of the forearms were born of healthy parents. Genetic counselling with regard to future children of one of these sibs was given on the assumption of an autosomal recessive inheritance, which is h... | 222,668 | [
-0.02138994,
0.0594102,
0.2214788,
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0.1426058,
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0.0291303,
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0.1854728,
0.3364066,
0.007319742,
... |
Studies on pituitary follitropin. V. Isolation of the subunits of the human hormone and reaction of the amino groups with acylating agents. | The alpha and beta subunits of human follitropin were isolated in a high state of purity. The tryptophan fluorescence of the native hormone and the isolated beta subunit are different. The N-terminus of the alpha and beta subunits was identified as valine and aspartic acid respectively. While recombination of the isola... | 222,701 | [
0.1868362,
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0.09211289,
0.2653051,
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... |
Disulfide bonds in Sendai virus glycoproteins. | The precursor of fusion protein (Fo) in Sendai virus growth in Vero cells can be cleaved by trypsin to forms F1 and F2, which can be resolved on SDS-polyacrylamide gels. However, if disulfide bonds are preserved during electrophoresis, F1 and F2 remain linked together even after trypsin treatment (F). Sendai virus grow... | 222,708 | [
-0.2134888,
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-0.08922431,
-0.06103905,
-0.6... |
Pyridine nucleotide cycle of Salmonella typhimurium: regulation of nicotinic acid phosphoribosyltransferase and nicotinamide deamidase. | Nicotinic acid phosphoribosyl transferase (NAPRTase) and nicotinamide deamidase activities from Salmonella typhimurium were examined regarding their regulation by either feedback inhibition or repression mechanisms. The results indicate that neither enzyme is subject to feedback inhbition. Nicotinamide deamidase does n... | 222,729 | [
-0.3235034,
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0.2249385,
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0.3813333,
0.0519907,
-0.1767083,... |
Phosphorylation of hydroxyproline in a synthetic peptide catalyzed by cyclic AMP-dependent protein kinase. | The cyclic AMP-dependent protein kinase catalyzes the phosphorylation of hydroxyproline present in the heptapeptide, Leu-Arg-Arg-Ala-Hyp-Leu-Gly. The Km value for the reaction with this substrate was high (approximately 18 mM) compared to the Km values reported for the analogous threonine and serine-containing peptides... | 222,752 | [
-0.2964075,
-0.4879861,
-0.6316146,
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0.0136257,
0.3077806,
0.3920133,
0.4307359,
-0.009765329,
-0.01202533,
-0.0... |
The effects of radiation sterilization on the properties of ultrahigh molecular weight polyethylene. | The effects of radiation sterilization on ultrahigh molecular weight polyethylene were explored by freeze fractures, electron spin resonance, absorption of aqueous media, density measurements, small-angle and wide-angle x-ray scatter, differential scanning calorimetry, infrared and ultraviolet-visible spectrometry, sta... | 222,766 | [
-0.09620345,
0.2482411,
0.3150977,
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0.07542124,
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0.2225079,
0.1610108,
-0.04001541,
-0.04935446,
... |
Pleocytosis and immunoglobulin changes in cerebrospinal fluid and herpesvirus serology in patients with Guillain-Barré syndrome. | In a follow-up study of 24 patients with Guillain-Barré syndrome, 55% developed a cerebrospinal fluid (CSF) mononuclear pleocytosis, which persisted for 4 months or more. Raised index values of CSF-immunoglobulin G (IgG), CSF-IgA, and CSF-IgM, indicating synthesis of the immunoglobulin in question in the central nervou... | 222,797 | [
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0.2917136,
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0.1598976,
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0.0884191,
-0.003881756,
-0.2490279,
-0.07149605... |
Decreased cerebrospinal fluid cyclic adenosine 3',5'-monophosphate in bacterial meningitis. | The concentration of cyclic adenosine 3',5'-monophosphate (cAMP) in 16 cerebrospinal fluid samples from eight patients with bacterial meningitis due to several different organisms was determined. An age- and sex-matched control group of 12 patients with a variety of acute, noninfectious systemic and neurological diseas... | 222,799 | [
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-0.4821445,
0.2769614,
0.3848203,
0.03727268,
-0.119... |
Counterimmunoelectrophoresis test for immunoglobulin M antibodies to group B coxsackievirus. | A counterimmunoelectrophoresis test was developed for immunoglobulin M (IgM) antibodies to group B coxsackievirus (CB) types 1 through 5. The IgM precipitin line could be identified and differentiated from the IgG line by treating sera with 2-mercaptoethanol. Antigen purity was demonstrated by single precipitin lines o... | 222,806 | [
-0.3316733,
0.05306451,
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0.06888944,
0.1755314,
-0.1153738,
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Diarrhea and rotavirus infection associated with differing regimens for postnatal care of newborn babies. | Surveillance of 2,041 babies born during 4 winter months in one obstetric hospital in Melbourne, Australia, showed that 215 developed acute diarrhea during the first 2 weeks of life. Babies requiring special care from birth had a high incidence of sporadic diarrhea (36%). The incidence of diarrhea among healthy full-te... | 222,807 | [
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... |
Impaired H2 histamine granulocyte response in active atopic eczema. | Many clinical abnormalities in atopic eczema have been attributed to an imbalance in autonomic nervous system control, specifically a partial blockade of beta-adrenergic responsiveness. The lysosomal enzyme beta-glucuronidase is released from granulocytes during in vitro incubation with complement-activated zymosan par... | 222,850 | [
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Pharyngoconjunctival fever caused by adenovirus type 4: report of a swimming pool-related outbreak with recovery of virus from pool water. | During the summer of 1977, an outbreak of pharyngoconjunctival fever (PCF) occurred at a private recreational facility in Georgia. A total of 72 cases of PCF was identified. Adenovirus type 4 (AV-4) was recovered from conjunctival or pharyngeal swab specimens from 20 of 26 persons in the group of cases tested. AV-4 was... | 222,852 | [
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Sialic acid content and growth control of mouse cells transformed by a temperature-sensitive mutant of SV40. | The sialic acid content of mouse cells transformed by a temperature-sensitive mutants (ts-mutant) of Simian virus 40 (SV40) was measured, and proved to be derived from changes in the sialic acid content in the plasma membrane which resulted from changes in the microsomal sialytransferase activity. Plasma membrane glyco... | 222,860 | [
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... |
Phosphodiesterase inhibition by succinic and related acid biphenylalkyl monoesters. | Biphenylalkyl monoesters of succinic and related acids represent a potent new class of cyclic AMP phosphodiesterase inhibitors. The biphenyl group is necessary for potent inhibition. The spatial relationship of the carboxyl and ester groups and alkyl chain length are important to inhibitory potency. | 222,890 | [
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Chemodectoma in the mid-thyroid region. | A chemodectoma (non-chromafin paraganglioma), which presented as a neck mass in the mid-thyroid region, is reported in a 36 year old female. Clinically, it resembled a thyroglossal duct cyst and on frozen section it looked like a thyroid adenoma. | 222,914 | [
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Growth factors and gangliosides: a possible new perspective in neuronal growth control. | For many permanent cell lines the transition from a growing (P) to a resting (R) state is reversibly controlled by growth factors present in serum. This P-to-R transition was studied in a neuronal cell line (B104) with respect to the action of serum, dibutyryl cyclic AMP (DBcAMP), gangliosides, and a glioma cell-produc... | 222,963 | [
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... |
Interaction between glycophorin and phospholipids in recombined systems. | Both the MN-glycoprotein from human erythrocytes and the hydrophobic fragment from the protein isolated with trypsin treatment, T(is), have been recombined with egg phosphatidylcholine in bilayers at various phospholipid/protein ratios. In order to investigate the effect of the protein on the phospholipid headgroups, 3... | 222,968 | [
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0.3565548,
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[Ectopic ACTH syndrome (author's transl)]. | Ectopic ACTH syndrome is a clinicopathologic condition produced by certain tumors which release hormone that is indistinguishable from ACTH. It orginates the chemical and clinical anomalies characteristic of Cushing's syndrome by its action on the adrenal glands. The tumors may be present in any organ, though they are ... | 222,977 | [
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... |
[Investigation of the hypoosmolal syndrome in carcinomas of the lung (author's transl)]. | A study was performed on 30 patients diagnosed antomopathologically for malignant neoplasia of the lung (epidermoid carcinomas, adenocarcinomas, oat-cell carcinomas, and neoplasias which could not be definitely classified). The following parameters for blood and urine were determined: osmolality, sodium, potassium, ure... | 222,978 | [
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0.4107622,
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[Macromolecule rotative correlation time measurement by ESR for covalently bound spin label]. | The dependence from temperature and viscosity of the shifts of the internal and external wide extremums in the ESR spectra of spin labelled bovine serum albumin has been studied. 2,2,6,6-tetramethylpiperidine-NI-oxyl-4-iodacetamide was used as a spin label. The obtained dependences was shown to be a consequence of the ... | 223,033 | [
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0... |
High-affinity uptake of gamma-aminobutyric acid in cultured glial and neuronal cells. | Both glial and neuronal cells maintained in primary culture were found to accumulate [3H]GABA by an efficient "high-affinity" uptake system (apparent Km = 9 muM, Vmax = 0.018 and 0.584 nmol/mg/min, respectively) which required sodium ions and was inhibited by 1 mM ouabain. Strychnine and parachloromercuriphenylsulfonat... | 223,077 | [
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0.03105772,
... |
Herpes virus infection as a cofactor in carcinogenesis: supernatants of herpes virus type 1- and type 2-infected cell cultures contain a cell growth-stimulating factor. | Some cell cultures synthesize a mitogenic factor (DNASF) following their lytic infection with either HSV-1 or HSV-2 which is shed into the medium. Of six cell lines permissive to HSV infection tested, three produce DNASF (CV1, HF, MCA) and a significantly higher (3H)-TdR incorporation was obtained with indicator cells ... | 223,098 | [
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0.33... |
Simian virus 40 recombinants are produced at high frequency during infection with genetically mixed oligomeric DNA. | Classical approaches to analysis of mitotic recombination by use of simian virus 40 (SV40) are limited in usefulness because of low frequencies of recombination. To bypass the apparent rate-limiting step in normal SV40 recombination, oligomeric SV40 was constructed in vitro by ligation of mixtures of pairs of linear DN... | 223,162 | [
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Evidence for internalization of the recognition site of beta-adrenergic receptors during receptor subsensitivity induced by (-)-isoproterenol. | In the supernatant (30,000 x g) of frog erythrocyte homogenates, by using gel filtration we detected a protein that could bind [(3)H]dihydroalprenolol ([(3)H]DHA) with high affinity. This binding was greatly enhanced when the erythrocytes were preincubated with (-)-isoproterenol. After various periods of incubation wit... | 223,168 | [
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Spontaneous vs. naloxone-induced abstinence in dependent rats self-administering L-alpha-acetylmethadol (LAAM) or morphine. | Rats maintained dependence by the self-administration of LAAM or morphine. Following the substitution of saline for LAAM, REM sleep was not disrupted, and the frequency of lever pressing for saline self-injections peaked at about 24 hr. In contrast, following the substitution of saline for morphine, REM sleep was suppr... | 223,173 | [
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Influence of opioids on central thermoregulatory mechanisms. | Of the effects of morphine and endogenous opioid peptides on thermoregulation, the one which is most likely to be of physiologic significance is hyperthermia. This increase in body temperature is the result of coordinated changes in both physiological and behavioral thermoregulatory activities and, like fever, reflects... | 223,174 | [
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The neurology of spinal pain. | The neuroanatomical and physiological aspects of pain derived from the spine are reviewed. An explanation is presented of the influence of passive movement as it relates to the interaction of the mechanoreceptor afferent nerves' modulation of nociceptive input. | 223,178 | [
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Effect of altitude hypoxia on ATPase activity in the brain of rats of different ages. | In experiments on 5-day-old and adult rats of both sexes, the authors investigated Na+--K+-stimulated and Mg2+-dependent ATPase activity in the cerebral cortex, subcortical formations and the medulla oblongata. They studied the effect of 20 min acute altitude hypoxia corresponding to either 7,000 or 9,000 m, in a therm... | 223,183 | [
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[Effects of different growth rates in weaned piglets, starvation and hormonal action, on various metabolic parameters in the blood plasma]. | Changes in concentrations of metabolites of the main nutrients in the blood plasma, caused by weaning and by different body weight gains, by starvation, exogenous adrenaline and ASTH administration were studied in 141 weaned piglets of the Large White breed at an age of 26 to 69 days. After weaning, the total protein l... | 223,271 | [
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[Trials to obtain a hyperimmune serum against bovine mucosal disease-virus diarrhea]. | Obtained are two types of hyperimmune sera against the virus of the mucous disease--viral diarrhea (MD--VD) by means of subcutaneous and venous hyperimmunization of cattle with a live viral suspension: (a) A polyvariant hyperimmune serum, obtained by the use of four local and reference strains of the MD--VD virus with ... | 223,277 | [
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Study of cell surface antigens induced by herpes simplex virus. Note I. Identification of the antigens by means of protein A-containing staphylococci. | A rapid, easy-to-perform and specific technique for the visualization of herpes simplex virus (HSV)-induced cell surface antigens is described. The technique consists in the incubation of HSV-infected cells with hyperimmune HSV antiserum and formation of rosettes with FITC-labelled Cowan strain staphylococci containing... | 223,281 | [
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0.24598... |
[Effect of hypophysectomy, hypophyseal explants and ACTH on the growth of human melanomas in diffusion chambers]. | Under study was the hypophysis influence on the growth of human melanoma explants, cultivated in the abdominal cavity of mice and rats. The heterotransplants growth was compared in intact and hypophysectomized animals exposed to ACTH, and also the effect of the murine hypophysis explanted into the adjacent chamber comp... | 223,325 | [
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0.02633889,
... |
[Development of immunity to the poliomyelitis virus in infants with various methods of administering a live poliomyelitis vaccine]. | The data have been obtained which indicate that the effectiveness of vaccination with live trivalent poliomyelitis vaccine may be increased and 90--100% of the vaccinated infants under 1 year of age may develop marked resistance of the alimentary tract and high antibody titers in the blood serum to the threee types of ... | 223,328 | [
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-... |
[Occupational metal poisoning (author's transl)]. | The early diagnosis of lead poisoning -- the most common type of occupational metal poisoning -- based on the determination of the haemprecursors coproporphyrin, delta amino laevulinic acid and free erythrocyte protoporphyrin. Treatment with chelating agents increases urinary lead excretion very effectively. Clinical m... | 223,335 | [
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0.2106493,
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... |
[Severe iatrogenic lesions caused by Huneke's neural therapy]. | During a combined acupuncture-neural therapy-treatment on account of a gastric ulcer several lesions with vast haemorrhages in the abdominal cavity and in the retroperitoneal space on the right (lesions of the kidney) were produced. At the operation a duodenal ulcer without perforation was found. The competence of the ... | 223,341 | [
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0.0101672,
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[The importance of Walthard inclusions from the stand point of differential diagnosis of the female genital tuberculosis (author's transl)]. | Walthard inclusions are described, which are frequent found like small nodules or cysts on the serosa of fallopian tubes and uterine ligaments under routine pelviscopy. The importance of Walthard inclusions is emphasized for distinguishing from the tubercles. During the three years period the incidence of Walthard incl... | 223,351 | [
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0... |
Pexid-induced rat retinal pathology. | Three morphologically distinct kinds of cytoplasmic inclusion (lamellar, reticular and crystalloid) developed in the retinal cells of suckling rats treated with Pexid (300 mg/kg/day). Lamellar inclusions were most abundant and they were seen in all types of retinal cells. This variety of inclusion was especially numero... | 223,368 | [
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-0.00490908,
-0.05971532,
0.03363208,
0.2714285,
-0.3253251,
-0.0717567,
-0.01859227,
0.1095793,
0.2459803,
0.04827441,
-0.04792968,
0.0425477,
0.2011888,
-0.2180476,
0.1331456,
-0.234642,
0.07103057,
0.03757112,
0.3178908,
0.2080474,
0.5120146,
0.05346609,
... |
Two dimensional echocardiographic quantification of infarct size alteration by pharmacologic agents. | In 27 closed chest dogs left ventricular wall motion abnormalities assessed quantitatively with two dimensional echocardiography were used as a measure of myocardial infarct size, and the change in extent of segmental wall motion abnormalities due to drug intervention early after infarction was evaluated. The extent of... | 223,427 | [
-0.2893202,
0.5848319,
-0.2717516,
-0.2998978,
0.04422629,
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0.02564461,
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0.05278058,
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0.2846381,
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0.1245765,
0.3757084,
0.01956084,
-0.0007184359,... |
Immunocytochemical evidence for anti-LHRH and anti-ACTH activity in the "F" antiserum. | An antiserum which has previously been thought to be specific for LHRH-like immunoreactive material was shown to contain two populations of antibodies, one demonstrating anti-LHRH activity and the other anti-ACTH(1-24) activity. In rat and mouse, ACTH(1-24)-like immunoreactive substance is present in perikarya within t... | 223,429 | [
-0.1562758,
0.003328924,
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0.06821305,
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0.388806,
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-0.09897995,
0.4522696,
0.1530179,
0.2080571,
0.05115158,
-0.1318581,
-0.2239... |
Computerized tomography in infantile encephalitis. | Although computerized tomographic (CT) findings are well recognized in numerous neurologic diseases of children, CT scan abnormalities of encephalitis have only been associated with herpes simplex infection. We describe two infants, one with coxsackievirus B2 meningoencephalitis and one with clinical encephalitis, whos... | 223,434 | [
-0.07270205,
0.1567283,
-0.05306474,
-0.4363132,
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0.2663043,
-0.09130754,
0.1522901,
0.1463584,
0.2143643,
-0.2131987,... |
Demonstration of specific antibodies to a coxsackie-like virus in patients of a hepatitis outbreak. | Lynchburg fecal virus (LFV), originally isolated from the stool of an infectious hepatitis patient, was passaged 15 times in WI-38 cells and partially characterized. Its properties are as follows: RNA virus; 27 nm in diameter, picornavirus-like morphology; inactivated at 56 C for 60 minutes; resistant to treatment with... | 223,437 | [
-0.2502203,
-0.1187705,
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0.1778637,
-0.1083986,
0.5499927,
0.2244147,
0.031792,
-0.3690729,
-0.... |
Dimethyl sulfoxide enhancement of phlebotomus fever virus plaque formation. | Dimethyl sulfoxide (DMSO)incorporated into an agar overlay containing DEAE-dextran enhanced plaque formation in Vero cells by Naples sandfly fever virus passaged in mouse brain or Vero cell cultures. No plaques were visible when DMSO was used without the DEAE-dextran, some plaques were rarely visible (less than 0.5mm) ... | 223,461 | [
-0.1596002,
0.2948388,
0.1175829,
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0.148431,
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0.1296584,
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0.06127463,
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-0.2599544,
0.1347806,
0.2830941,
0.07953626,
-0.1023591,
-0.07647406,
-... |
Discriminant analysis: a method of identifying foci of vector-borne diseases. | Identification of foci of vector-borne diseases does not require knowledge of exact abundances of vectors and pathogens; rather, a focus is defined by the presence, or some minimal level of abundance, of a vector and pathogen. Stepwise discriminant analysis (DA) was applied to data on free-ranging adult wood ticks (the... | 223,462 | [
0.01181452,
0.4334758,
0.02676247,
0.07513312,
-0.08641831,
-0.3765973,
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0.2661866,
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0.08816458,
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-0.1354669,
0.2651427,
0.5117611,
0.2418039,
-0.0486869,
-0.04219498,
-0.1812394,
... |
Abnormal auditory evoked potentials in hereditary motor-sensory neuropathy. | From a kinship with a dominantly inherited motor-sensory neuropathy, we studied 2 brothers with brainstem auditory evoked potentials and behavioral audiometric tests. They had abnormal prolongation of I-III interpeak intervals. Wave V was poorly developed. Conventional audiometric tests did not reveal a peripheral hear... | 223,494 | [
-0.08865122,
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0.009397004,
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0.02306344,
0.1494169,
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0.04217046,
-0.5100633,
0.108869,
-0.2502416,
-0.01032324,
0.04751527,
0.09955148,
0.341... |
Immunohistochemical evidence for RNA virus related components in human breast cancer. | The localization of antigenic components with cross-reactivity to a 52,000 dalton group specific glycoprotein (gp52) of the mouse mammary tumor virus (MMTV) in paraffin sections of human breast carcinomas is described using an indirect immunoperoxidase method. This method was first optimized on paraffin sections of mou... | 223,491 | [
-0.293588,
-0.2253854,
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0.1144637,
0.2487787,
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-0.1762731,
-0.1222038,
-0.1740161,
0.3929969,
-0.2238232,
-0.1165966,
0.00... |
A new method for obtaining viable cells from dermal infiltrates. A study on 2,4 dinitrochlorobenzene induced contact dermatitis. | Experimental contact dermatitis has been induced in 2,4 dinitrochlorobenzene (DNCB) sensitized guinea pigs. The developing dermal infiltrate was excised and the infiltrating cells were obtained by mechanical extraction alone as well as by the combination with collagenase and elastase treatment. The most viable cells ap... | 223,502 | [
0.07886607,
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0.09030967,
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0.02342309,
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0.2932605,
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-0.354855,
0.143603,
-0.1284768,
0.454545,
0.09270735,
0.4488974,
-0.1356535,
... |
Effect of ACTH and corticosterone on melanogenesis and cyclic nucleotide levels in the B-16 melanoma. | The acute in vitro action of ACTH and corticosterone individually and in combination were determined in the B-16 melanoma grown in vivo. ACTH elevated levels 10-fold while tyrosinase activity generally was depressed. Corticosterone depressed cAMP levels and tyrosinase activity. ACTH in the presence of corticosterone pr... | 223,504 | [
-0.2348583,
-0.3202694,
-0.3898816,
-0.2696956,
0.02797057,
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-0.05926147,
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0.07611347,
-0.1198496,
0.03876206,
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-0.4952549,
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-0.08981778,
0.05204319,
0.09265708,
0.4268972,
0.4520471,
-0.1485879,
-0.1868795... |
Essential fatty acid deficiency in total parenteral nutrition. Detection by changes in intraocular pressure. | Essential fatty acid deficiency (EFAD) has been commonly and readily diagnosed during fat-free total parenteral nutrition (TPN), with only vague awareness of possible functional and clinical derangements secondary to essential fatty acid deficiency. Arachidonic acid is known to be a precursor for prostaglandin (PG) syn... | 223,507 | [
-0.2625543,
-0.2171218,
-0.207082,
-0.617895,
0.3940972,
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0.117494,
0.08685265,
0.0123234,
-0.438651,
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0.1278504,
0.05048843,
-0.09016077,
-0.3740487,
-0.002597082,
-0.4030671,
-0.1043089,
-0.3607731,
0.4730813,
-0.1578879,
0.3353207,
0.05483322,
... |
Phosphate inhibition of secondary metabolism in Streptomyces hygroscopicus and its reversal by cyclic AMP. | Inorganic phosphate inhibited the biosynthesis of the macrolide antibiotic turimycin in different strains of Streptomyces hygroscopicus. In the wild type strain a depression was observed with increasing phosphate concentrations. A total inhibition was found at 0.1 M phosphate. In a high producing mutant a minimum of tu... | 223,512 | [
-0.1250981,
-0.1253903,
-0.07270335,
-0.2887865,
0.2071989,
0.02277307,
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0.229649,
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0.06484924,
0.103714,
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0.1992051,
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0.3151953,
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-0.02633197,
-0.0268831,
0.1587461,
0.4558136,
-0.02082463,
-0.226844,
... |
Modulation by sodium ascorbate of the effect of chloroquine on low density lipoprotein retention and degradation in cultured human skin fibroblasts. | Human skin fibroblasts in culture were incubated for 48 h with 125I-labelled low density lipoprotein and chloroquine in the presence and absence of sodium ascorbate. Pretreatment of the cells for 3 days with sodium ascorbate and addition of the vitamin during incubation resulted in a decrease in cellular retention and ... | 223,588 | [
-0.07509562,
0.1937281,
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-0.08674847,
-0.04814771,
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0.0184844,
0.1818973,
0.0485598,
0.06659806,
0.4937312,
0.2915475,
0.01001661,
-0.3504851,
0.1546465,
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-0.2110292,
-0.248614,
0.5913705,
0.1075685,
0.2008546,
-0.117982,
0.... |
[Histological and electron microscopic study of the cerebral cortex of the progeny of neurosensitized rats]. | The sensomotor brain cortex of 30-day ratlings born by preliminary neurosensitized females, was studied. The studies demonstrated retardation in the development of the brain cortex in the progeny. Electon microscopic examinations detected certain features in the structure of cellular organella, as well as membrane form... | 223,605 | [
0.169525,
-0.1101203,
0.2392065,
-0.01574048,
0.1972319,
-0.3386476,
-0.561183,
-0.4646693,
0.1722209,
0.00000679016,
0.2449735,
0.02448816,
0.1136104,
0.1963367,
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-0.1849569,
0.0535082,
-0.3280897,
0.1471958,
0.2847158,
0.1668537,
-0.009601492,
-... |
Purine metabolism in microplasmodia of Physarum polycephalum. | The uptake and utilization of purine nucleosides and purines in microplasmodia of Physarum polycephalum were investigated. The results revealed a unique pattern, namely that exogenous purine nucleosides are readily taken up and metabolised, while free purine bases are hardly taken up. The pathways of incorporation have... | 223,640 | [
-0.4702797,
-0.04063123,
-0.1508461,
0.003572063,
0.138883,
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-0.2113508,
0.1684817,
0.06894156,
0.1489976,
0.1889782,
-0.05130597,
-0.1090972,
-0.02790078,
-0.3193594,
0.2928168,
-0.5922074,
0.3416477,
-0.1395505,
0.09490611,
0.694468,
0.3115,
-0.2157532,
-0.... |
[Study of lipid dependence of glucose-6-phosphatase from rat liver and hepatoma using lipid exchange proteins]. | In order to study the lipid dependence of glucose-6-phosphatase the lipid composition of microsomes from rat liver and hepatoma was modified using lipid exchange proteins. It was shown that the enzyme activity depends on the presence of phosphatidyl ethanolamine and phosphatidyl serine, but is unaffected by the enrichm... | 223,670 | [
0.05146255,
-0.2787613,
-0.335885,
-0.06548437,
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0.211178,
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-0.04033484,
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-0.2243796,
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-0.2001793,
-0.5192853,
0.02025004,
0.105462,
0.1649063,
0.4177857,
0.006273485,
-0.0791... |
An assessment of computerised isotopic renal section scanning. | The basic non-invasive investigation of renal space occupying lesions by excretion pyelography was coupled with ultrasonic scanning. Forty-one patients who have undergone isotopic section scanning as part of their investigative assessment were studied. The conditions investigated included solitary cysts, polycystic kid... | 223,709 | [
-0.2210303,
0.2255029,
-0.2382665,
-0.1954223,
0.03554184,
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0.1914348,
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0.0442941,
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0.2790996,
-0.2124464,
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-0.2351929,
0.009173531,
-0.08247324,
-0.479806,
0.0970935,
0.2239377,
-0.2772997,
... |
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