title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. | Sensory neurons grown in dispersed cell culture in the absence of non-neuronal cell types contain immunoreactive substance P that is chemically similar to synthetic substance P. When depolarized in high-K+ media (30-120 mM), the neurons release this peptide by a Ca2+-dependent mechanism. An enkephalin analogue, [D-Ala2... | 218,204 | [
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Strand-specific attachment of avidin-spheres to double-stranded poliovirus RNA. | Poliovirus-specific double-stranded RNA molecules containing covalently attached protein were coupled with a biotin ester through the protein moiety. Subsequent interaction of the RNA-biotin with avidin attached to electronopaque plastic spheres led to the formation of complexes that were easily visualized in the elect... | 218,216 | [
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[Cancer epidemiology and French medical data (author's transl)]. | The authors remind: cancerous disease's possibilities of description before any treatment through its topography, its morphology and its clinical medicine; the modalities for taking surgical, actinic, chemical, immunologic therapeutics in account; the technics of the cancerous disease supervision after treatment, from ... | 218,258 | [
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[Network for the epidemiological survey of the enteroviruses in sewage (author's transl)]. | Poliomyelitis still occurs each year in France: 27 cases in 1973, 21 cases in each of 1974 and 1975, 8 cases in 1976. Because of the risk, a survey of the spread of poliovirus in healthy populations and in sewage was organized by the Ministry of Health according to the departmental note DGS/HP/1st/250, 9-2-73. The Labo... | 218,261 | [
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Plasma lecithin:cholesterol acyltransferase activity in hypophysectomized rats. | Hypophysectomy in rats induces a decrease in VLDL and HDL and an increase in LDL. To investigate the importance of lecithin:cholesterol acyltransferase (LCAT) for these changes, plasma LCAT activity was determined, both according to the methods of Stokke-Norum and Glomset-Wright. Plasma LCAT activity as assessed by bot... | 218,273 | [
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Studies on intrarenal prostaglandins. Effect of unilateral renal artery constriction on lipid droplets in the medullary interstitial cells of the 'opposite' kidney in rabbits. | The unilateral renal artery in rabbits was constricted, and lipid droplet count in the medullary interstitial cells of the 'opposite' kidney was performed 1 week after surgery. Lipid droplet count in hypertensive rabbits was less than that in both nonhypertensive and normal rabbits and was inversely proportional to the... | 218,332 | [
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Response of plasma non-conjugated oestradiol to manipulated adrenal function by ACTH and dexamethasone. | The present study is concerned with the regulation of free plasma oestradiol in relation to maternal adrenal function during late human pregnancy. Blood was collected in 9 patients at short time intervals of 30 min from 17 h to 3 h. In order to exclude endogenous ACTH-secretion 5 patients received 12 mg dexamethasone o... | 218,416 | [
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Ultrastructure of the nerve cells and fibres in the urinary bladder wall of the cat. | The nerve elements in the urinary bladder of the cat were studied by electron microscopy. According to their ultrastructure, nerve cell somata can be classified into three types: the large cells with a cytoplasm rich in organelles, several processes and numerous synaptic contacts on their surface; the cytoplasm contain... | 218,422 | [
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Desoxycorticosterone in normal pregnancy. II. Cortisol-dependent fluctuations in free plasma desoxycorticosterone. | Desoxycorticosterone (DOC) secretion increases during pregnancy. Administration of adrenocorticotropic hormone (ACTH) to women during the third trimester of pregnancy was noted previously to result in marked sodium retention, while aldosterone excretion declined. Since urinary tetrahydrodesoxycorticosterone increased s... | 218,456 | [
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Time course of the T3- and T4-induced increase in rat soleus muscle mitochondria. | Citrate synthase and cytochrome c increase in soleus muscle of rats in response to excess thyroid hormones. The half times of the increase in the levels of citrate synthase and cytochrome c in soleus muscle during induction are greater than the half times of the decline in enzyme levels after cessation of treatment (15... | 218,461 | [
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Induction of delta-aminolevulinic acid synthetase in muscle by exercise or thyroxine. | There is evidence that delta-aminolevulinic acid (ALA) synthetase is the rate-limiting enzyme in heme biosynthesis. Accumulation of the apoproteins of the mitochondrial cytochromes appears to be regulated by availability of heme. Exercise and thyrotoxicosis bring about increases in the cytochromes, and in other mitocho... | 218,464 | [
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Physical activity and plasma cyclic adenosine monophosphate levels in manic-depressive patients and healthy adults. | Intense exercise for one hour induced a significant increase in plasma cyclic adenosine monophosphate (cAMP) in 5 healthy volunteers. In 44 manic-depressive patients, cAMP levels correlated more strongly with mood ratings than with activity scores. The authors conclude that physical activity is one of the factors which... | 218,466 | [
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The effect of vaccination on titres of antibody to rotavirus in colostrum and milk. | The continued presence of antibody to rotavirus in the gut of the neonatal ruminant has been shown to be important in protecting against clinical disease associated with rotavirus infections. This effect is dependant upon the amount of antibody included in the diet. Titres of antibody to rotavirus may be relatively hig... | 218,490 | [
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Effects of nucleoside analogs on Epstein-Barr virus-induced transformation of human umbilical cord leukocytes and Epstein-Barr virus expression in transformed cells. | Two methods of assay, measuring (i) stimulation of host cell DNA synthesis by [(3)H]thymidine incorporation and (ii) morphological transformation in microtiter plates, were employed to determine what effect treatment during infection with adenine arabinoside or 5-iodo-5'-amino-2',5'-dideoxyuridine has on Epstein-Barr v... | 218,497 | [
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Enveloped virus inactivation by fatty acid derivatives. | The enveloped bacteriophage phi6 has been shown to be a valuable model system for the preliminary screening of compounds that might be expected to inactivate herpes simplex virus and other enveloped mammalian viruses. A variety of fatty acid derivatives that form fluid micelles in aqueous media have been found to be po... | 218,498 | [
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Noninvasive breast carcinoma: frequency of unsuspected invasion and implications for treatment. | One hundred twenty-nine biopsies from 121 patients with a frozen or paraffin section diagnosis of noninvasive breast carcinoma were studied. Eight women had bilateral noninvasive carcinoma. Seven biopsies reported as intraductal on frozen section contained invasive carcinoma on paraffin section. Of the remaining 122 bi... | 218,506 | [
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Male breast carcinoma. An ultrastructural study. | A case of infiltrating ductal carcinoma of the male breast was studied by electron microscopy. The ultrastructure of the tumor is similar to that described in the female breast. Myofibroblasts are the preponderant cells in the stroma. Their significance and possible relation to hormonal stimuli are discussed. | 218,521 | [
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Comparison of the morphology of three coronaviruses. | The morphology of three coronaviruses, avian infectious bronchitis virus strain Connecticut (IBV Conn), human coronavirus strain 229E (HCV 229E) and mouse hepatitis virus strain 3 (MHV3), were examined by negative staining. Significant differences were found in the sizes of the three coronaviruses. Furthermore, three t... | 218,534 | [
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6 beta-Bromopenicillanic acid inactivates beta-lactamase I. | The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reacti... | 218,563 | [
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Alterations in the expression of the cytomegalovirus-induced cytopathogenic effect in fibroblasts by aflatoxin B1. | Aflatoxin B1 has been shown both to promote and to alter the expression of the cytopathogenic effect observed when human fibroblasts are challenged with human cytomegalovirus (CMV). Although the cells become round, as is the characteristic effect of this virus on fibroblasts, multinucleate cells are seen to arise from ... | 218,602 | [
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Stimulation of resistance against local tumor growth, of hosts pretreated by combined local hyperthermia and X-irradiation. | The relationships involved in host resistance to tumor development were studied. Animals were pretreated by local hyperthermia, local irradiation and combined local hyperthermia and x-irradiation. After treatment, the animals were inoculated with tumor cells 0--96 or 0--120 hours post treatment. (BALB/c X C57B1/6)F1 mi... | 218,660 | [
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Mechanisms of augmented field potential responses in the rat olfactory bulb. | Olfactory bulb field potential and single unit responses to paired pulse stimulation of the lateral olfactory tract were observed in the rat. In agreement with previous reports, surgical levels of barbiturate anesthesia prolonged the period of diminution of the field potential responses to the test pulse relative to th... | 218,678 | [
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The calf reo-like virus (rotavirus) vaccine: an ineffective immunization agent for rotaviral diarrhea of piglets. | Rotavirus, in a commercially available calf vaccine, did not replicate in newborn colostrum-free piglets inoculated orally with one half of a calf dose. Gross and microscopic examination of these vaccinated piglets revealed no lesions consistent with rotaviral infection and vaccinated piglets were susceptible to challe... | 218,709 | [
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Humoral antibody response to bovine leukemia virus infection in cattle and sheep. | In this study, 345 cattle from 7 herds with a history of lymphosarcoma were tested for antibody to BLV antigens by three serological methods, namely immunodiffusion using a bovine leukemia virus glycoprotein with a molecular weight of 60,000 as antigen, and radioimmunoassay using a bovine leukemia virus glycoprotein wi... | 218,722 | [
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Thymidine and hypoxanthine requirements for the proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts in the presence of methotrexate. | Cultured normal and Rous sarcoma virus-infected chicken fibroblasts do not differ in the concentrations of thymidine or of hypoxanthine that they require to proliferate in the presence of a methotrexate block. For maximal proliferation, thymidine is required at 10(-6) M, while hypoxanthine is required at 10(-5) M. The ... | 218,735 | [
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Action of 2-acetamido-2-deoxy-beta-D-hexosidase from Turbo cornutus on periodate-oxidized and Smith-degraded, blood-group HLeb and Lea substances from human, ovarian-cyst fluids. | Immunochemical and chemical studies were used to monitor and evaluate the structural changes produced by an enzyme from Turbo cornutus in periodate-oxidized and Smith-degraded, human blood-group substances from ovarian cysts. After the first step of periodate oxidation and Smith degradation, two blood-group substances,... | 218,737 | [
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Circadian rhythms of the functions of thrombocytes and basophils in the blood of healthy volunteers and of patients with ischaemic heart disease. | The circadian rhythms of the functions of the cellular components of haemostasis, and their response to administration of ACTH, were studied in 30 healthy volunteers and in 17 patients with cardiosclerosis secondary to past myocardial infarction. A biphasic periodicity was found of the counts and functional activities ... | 218,772 | [
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Thyroid plasma membrane-associated protein kinases: properties and substrates of solubilized and insoluble enzymes. | The protein kinase activities of thyroid plasma membranes were characterized after treatment by the nonionic detergent, Triton X-100. With endogenous substrate the protein kinase activity of intact plasma membranes appeared to be cAMP independent, whereas the solubilized plasma membranes contained a cAMP-dependent prot... | 218,787 | [
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0.3806978,
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-0.392587,
0.322... |
Suppression of aldosterone biosynthesis by treatment of rats with adrenocorticotropin: comparison with glucocorticoid effects. | The treatment of rats with a high dose of ACTH resulted within 4 days in a marked suppression of aldosterone and deoxycorticosterone outputs by capsular adrenal tissue ("zona glomerulosa") incubated with and without serotonin and in decreased conversions of tritiated corticosterone and deoxycorticosterone to aldosteron... | 218,801 | [
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... |
Purification and characterization of the messenger RNA coding for bovine corticotropin/beta-lipotropin precursor. | The mRNA coding for the common precursor of corticotropin and beta-lipotropin has been purified to homogeneity from neurointermediate lobes of bovine pituitaries. The homogeneity of the mRNA preparation is evidenced by analysis of its translation product, electrophoresis on polyacrylamide gel in the presence of formami... | 218,809 | [
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Dependence of intracellular alkali-ion concentrations of 3T3 and SV 40-3T3 cells on growth density. | Intracellular contents of potassium and of sodium are determined for 3T3 and SV 40-3T3 cells in dependence of growth density. In parallel, total cell volume and volume of intracellular water is determined for these cells suspended in physiological buffer. Intracellular potassium concentration thus evaluated for suspend... | 218,856 | [
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Small intestinal morphology and epithelial cell kinetics in lamb rotavirus infections. | Morphologic changes in the small intestine of rotavirus-infected gnotobiotic lambs were investigated by measurement of villi and crypts in histologic sections of jejunum, midgut, and posterior ileum. In midgut, villus atrophy developed within 12 hr of infection and was apparent until 72 hr after infection. Crypt hypert... | 218,864 | [
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Adrenocorticotropin. 52 Synthesis and biological activity of adrenocorticotropic peptides with cystine bridges. | Three analogs of the amino terminal nonadecopeptide of adrenocorticotropin which incorporate cystine cystine bridges between positions (5, 10), (3, 10), or (2, 10) have been synthesized. All of the peptide analogs showed reduced biological activity; however, the peptide with the 5, 10 cystine bridge was shown to posses... | 218,890 | [
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Reduction of 51Cr-permeability of tissue culture cells by infection with herpes simplex virus type 1. | Infection of different strains of tissue culture cells with herpes simplex virus type 1 (HSV-1) resulted in a reduced 51Cr-permeability. A stability of the cellular membrane to Triton X-100, toxic sera and HSV-specific complement-mediated immune-cytolysis could be observed simultaneously. The results differed with resp... | 218,898 | [
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Hybridization of bovine papilloma virus type 1 and type 2 DNA to DNA from virus-induced hamster tumors and naturally occurring equine tumors. | DNAs from bovine papilloma virus(BPV)-induced hamster tumors and from equine connective tissue tumors of unknown etiology were examined for BPV DNA sequences by molecular hybridization. DNA from two distinct classes of BPV (type 1 and type 2) was labeled in vitro and used as probes. Analysis of DNA-DNA reassociation ki... | 218,902 | [
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A case of McCune-Albright syndrome with hyperthyroidism and vitamin D-resistant rickets. | A girl aged 1 11/12 year with the unusual combination of McCune-Albright syndrome (polyostotic fibrous dysplasia, cutaneous pigmentation and precocious puberty), hyperthyroidism and vitamin D-resistant rickets is described. Urinary estrogens are increased, while serum LH and FSH responses to LH-RH are subnormal. Thyroi... | 218,906 | [
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Regulatory interactions between mitochondrial genes. I. Genetic and biochemical characterization of some mutant types affecting apocytochrome b and cytochrome oxidase. | The region of the mtDNA containing the structural gene for apocytochrome b is called the cob or box region. There is evidence that the same region is also involved in the regulation of cytochrome oxidase. We have isolated eight mit- mutants in this region and have ordered them using petite deletion mapping. Four of the... | 218,939 | [
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Pseudohypoaldosteronism: multiple target organ unresponsiveness to mineralocorticoid hormones. | The first report of a 7-month-old male with pseudohypoaldosteronism in which unresponsiveness to mineralocorticoids has been demonstrated in the kidney, colon, and sweat and salivary glands is presented here. This is documented by urinary, salivary, and sweat sodium wasting in the presence of elevated urinary aldostero... | 218,983 | [
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Adrenocorticotropin-stimulated secretion of aldosterone and cortisol, computed from plasma and red blood cell measurements. | The dynamic response of the adrenal cortex to ACTH infusion is analyzed by simulating the distribution, binding, and metabolism of cortisol and aldosterone in a multicompartmental model. The model includes the effects of temperature and cortisol concentration on aldosterone binding in plasma and the distribution betwee... | 218,994 | [
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Phentolamine and the action of somatostatin in man. | The inhibition by somatostatin (SRIF) of basal and arginine-stimulated glucagon, insulin, and glucose levels was compared with that obtained when SRIF was preceded by alpha-adrenergic blockade with phentolamine. No noteworthy differences were observed, except that the characteristic rebound of insulin upon discontinuat... | 219,013 | [
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Comparison of occurrence of antibodies to human cytomegalovirus as demonstrated by immunofluorescence and indirect hemagglutination techniques. | Indirect immunofluorescence and hemagglutination study of reactivity to human cytomegalovirus immediate early, early, and late antigens revealed that antibody responses to these antigens varies greatly and that hemagglutination is positive when sera contain only antibody to one or both early antigens. | 219,018 | [
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Differential sensitivity of lymphocyte subpopulations to suppression by low density lipoprotein inhibitor, an immunoregulatory human serum low density lipoprotein. | Reports by a number of investigators have described the thymus-derived (T)-cell dependence of immunoglobulin synthesis by pokeweed mitogen (PWM) stimulated human peripheral blood bone marrow-derived (B) cells. Because of the cooperative nature of this in vitro system, it was chosen for examination of the differential e... | 219,033 | [
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... |
Continuous-flow analysis of ammonia in perchloric acid supernate of blood or plasma using an ammonia-selective electrode. | A simple automated method for the estimation of ammonia in perchloric acid supernate of blood or plasma using an ion-selective electrode (Orion Ammonia-selective electrode, Model 95-10) is described. The reliability of the proposed method has been checked against an ion-exchange resin procedure, which has been chosen a... | 219,039 | [
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Some age-related changes in pituitary-adrenal function in the male laboratory rat. | Changes in the pituitary-adrenal axis have been investigated as a function of age (2 1/2 to 26 mo) in the male laboratory rat (CFY-Sprague Dawley). Ether stress was used to challenge the pituitary-adrenal axis and blood samples (peripheral and adrenal venous effluent) taken for measurement of corticosterone using the c... | 219,055 | [
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Enhancement by disulfiram (Antabuse) of toxic effects of 95 to 97% O2 on the rat lung. | Disulfiram (Antabuse), a drug used in alcohol aversion therapy, has been demonstrated to protect various species against hyperbaric O2 toxicity. In contrast, we have found that disulfiram accelerates the onset of pulmonary edema and death of rats exposed to normobaric 95 to 97% O2. When rats were given 200 mg of disulf... | 219,176 | [
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Effect of polybrominated biphenyls on the development of hepatic excretory function. | Polybrominated biphenyls (PBBs) stimulate hepatic drug metabolism in adult and developing rats. The purpose of this investigation was to determine the influence of PBBs on the development of the liver as an organ for chemical excretion. Exposure of developing rats to polybrominated biphenyls (PBBs) by feeding 50 ppm of... | 219,178 | [
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0.6453611,
0.00016132... |
Morphological and biochemical characterization of viral particles produced by the tsO45 mutant of vesicular stomatitis virus at restrictive temperature. | The growth at restrictive temperature of tsO45, a group V (glycoprotein) conditional lethal mutant of vesicular stomatitis virus (VSV), was demonstrated to result in the production of large numbers of noninfectious viral particles. The infectivity of these tsO45 particles could be enhanced by procedures known to promot... | 219,217 | [
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Mutational alterations within the simian virus 40 leader segment generate altered 16S and 19S mRNA's. | We have analyzed the structure of the late cytoplasmic RNAs made after infection with wild-type simian virus 40 and a set of viable mutants, four of which have deletions and one an insertion within the nucleotide sequence specifying the leader segment of the 16S and 19S mRNA's. The principal findings are: (i) simian vi... | 219,218 | [
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0.09770165... |
Adenovirus type 12 gene 401 function and maintenance of transformation. | Rat (3Y1) and hamster embryo brain cells were transformed by wild-type adenovirus type 12 or the DNA-minus temperature-sensitive mutant ts401. The ts401-transformed 3Y1 cells, but not the wild-type transformants, displayed a temperature-sensitive response with respect to the following characteristics of the transformed... | 219,220 | [
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0.053... |
Integration of Rous-associated virus type O provirus in susceptible chicken cells. | The number of viral genome equivalents per haploid cell genome was determined in normal chicken embryos from three selected chicken lines and in cultured fibroblasts (CEF) from these embryos. The cellular concentration of endogenous proviral DNA is similar in embryos from chickens of lines SPAFAS, 7, 15, 7 x 15, and 10... | 219,233 | [
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... |
Murine mammary tumor virus expression during mammary tumorigenesis in BALB/c mice. | Steady-state levels of murine mammary tumor virus (MuMTV) RNA were quantitated during mammary tumorigenesis in BALB/c mice by molecular hybridization with a representative MuMTV complementary DNA (cDNA) probe. Hyperplastic alveolar nodule (HAN) lines are preneoplastic mammary lesions that were induced in BALB/c mice by... | 219,243 | [
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0.4325592,
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Nucleosomal structure of Epstein-Barr virus DNA in transformed cell lines. | Micrococcal nuclease digestion was used to analyze Epstein-Barr virus (EBV) DNA structure in nuclei of transformed cells. Digests of virus-producing (P3HR-1), non-virus-producing (Raji), and superinfected Rajii cell nuclei were fractionated by electrophoresis on agarose gels, transferred to nitrocellulose, and hybridiz... | 219,253 | [
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Phosphorylation of T-antigen and control T-antigen expression in cells transformed by wild-type and tsA mutants of simian virus 40. | Chinese hamster lung (CHL) cells transformed by wild-type simian virus 40 (cell line CHLWT15) or transformed by the simian virus 40 mutants tsA30 (cell lines CHLA30L1 and CHLA30L2) or tsA239 (cell line CHLA239L1) were used to determine the rates of turnover and synthesis of the T-antigen protein and the rate of turnove... | 219,256 | [
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A serological assay for the detection of cell surface receptors of nerve growth factor. | When single-cell suspensions prepared from embryonic day 8 (E8) chick sensory ganglia are incubated with nerve growth factor (NGF), anti-NGF antiserum, and complement, an NGF-dependent cytotoxic kill of 20 (+/- 3)% of the ganglia cells is observed. This percentage is increased by a factor of two when only the neuronal ... | 219,297 | [
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Etiology of pediatric gastroenteritis in Rochester, Minnesota. | The cause of diarrhea in a Rochester, Minnesota, pediatric population was studied by examining specimens for the presence of enterotoxigenic strains of Escherichia coli and reovirus-like agents, in addition to parasites and other bacteria and viruses. Reovirus-like agents were detected by electron microscopy in the fec... | 219,302 | [
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-0.04950321,
0.1585786,
0.2588388,
0.05984853,
-0.3089619,
0.3003216,
-0.2167978... |
[Ductal carcinoma of the salivary glands. Case report]. | A rare case of carcinoma of the salivary gland ducts highlights potential clinical malignity and the need for adequate therapeutic action, aimed above all at preventing the onset of recurrences and metastasis, including cases which have been clearly differentiated histologically. | 219,324 | [
-0.143052,
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0.... |
[Study of ganglioside therapy in maxillofacial surgery]. | 56 patients have been treated with cerebral gangliosides by the Authors. They underwent a maxillo-facial operation due to various pathological reasons (traumas, tumors, malformations). They presented secondary symptoms such as neurological deficits of the V and VII paired cranial nerves. The recovery from neurological ... | 219,325 | [
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Hepatocyte growth control: in vitro approach to problems of liver regeneration and function. | Primary monolayer fetal and adult rat hepatocyte culture systems, which are being used to help analyze in vivo mechanisms controlling liver regeneration, proliferation, and differentiation are described. With results from animal studies of normal or genetically altered rats subjected to partial hepatectomy, to chemical... | 219,365 | [
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Preliminary studies of sera and urine from patients with bladder cancer. | Some preliminary observations may be helpful as we proceed with studies of the humoral and cellular reactions in body fluids. 1) In the reactions with TAA from primary bladder cancers and from bladder cancer cell lines, we must be aware of complexing when we study sera or tumors from patients with more invasive tumors.... | 219,366 | [
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Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease. | A child with lactic acidosis, severe mental and developmental retardation, and proximal renal tubular acidosis is presented. Biopsy and autopsy studies show severe hepatic, renal cortical, and cerebral deficiencies in pyruvate carboxylase (EC 6.4.1.1) activity. The patient had 1.81 +/- 0.20 units/g fresh weight at biop... | 219,411 | [
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[Glucose catabolite repression of glucoamylase biosynthesis by the yeast Endomycopsis fibuligera]. | The effect of glucose, sucrose, fructose, maltose, alpha-methyl glucoside, glycerol, nonmetabolizing glucose analog--2-deoxy-D-glucose, and cyclic 3',5'-adenosine monophosphate (cAMP) on the glucoamylase biosynthesis by the yeast Endomycopsis fibuligera 20-9 was investigated. The sugars tested induced repression of the... | 219,427 | [
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Effects of cyclic AMP altering drugs on endotoxin-induced termination of pregnancy. | The effects of dibutyryl-cyclic AMP (DBcAMP), propranolol, and theophylline on endotoxin (LPS) challenged pregnant mice was determined by comparing the patterns of termination and times of fetal expulsion. Endotoxin isolated from wild type (WT) and Re chemotype mutant cells of Salmonella typhimurium was used. Wild type... | 219,454 | [
-0.05484311,
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0.152553,
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... |
Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5. | The genetic linkage of the endogenous C3H/HeJ C-type ecotropic virus to phosphoglucomutase-1 (0.28, recombinant fraction) on chromosome 5 was established by means of serological assays of backcrossed mice. With a combination of serological techniques and DNA-DNA hybridization the BALB/c endogenous ecotropic virus was s... | 219,476 | [
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... |
[Contraception in diabetic women (author's transl)]. | Contraception in diabetic women is necessary in order to plane pregnancies. Patients with chemical diabetes or family story of diabetes, babys with birth's weight over four kilogrammes, pregnancy's diabetes, may not use oestroprogestative pills. In this group progestins minipills can be used. Insulin-treated women may ... | 219,507 | [
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0.1062523,
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[Primary hyperparathyroidism. Current aspects of its diagnosis apropos of a case with digestive and neuropsychiatric manifestations]. | On the basis of a dramatic hypercalcemia revealed by digestive and neuropsychic symptoms and related to a primary hyperparathyroidism, the authors recall all the clinical circumstances which should lead to determination of plasma calcium as well as the clinical and biological particularities which, in front of a hyperc... | 219,510 | [
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[Remarks about twelve cases of pneumococcal septicemias (author's transl)]. | Twelve cases of pneumococcal septicemias are studied in a department of internal medicine. These septicemias involved pneumonias often large, multilobular and bilateral, with often pleural effusion purulent or not and in one occurrence meningitis. There was three deaths by acute respiratory failure in one case of liver... | 219,513 | [
0.1026467,
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0.06501766,
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0.1377222,
0.3326147,
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0.03318428,
... |
[Optic neuritis and sarcoidosis (author's transl)]. | Case report of a sarcoidosis in a young west-indies feurale: ganglio-mediastinal and lung lesions, liver and salivary glands right optic nerve with retrobulbar optic neuritis. This lesions were quickly and totally reversible with tetracosactide and prednisone therapy. | 219,516 | [
-0.05025103,
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0.08010969,
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0.3319068,
0.05921... |
[Kinetics of bone uptake of 99m Tc-labeled diphosphonates. Preliminary results]. | The bone fixation of diphosphonates depends on the degree of osteogenesis, the blood bone flow and the capillary permeability. The precise characteristics of the fixation kinetic are not very well known. The authors propose a new method which makes possible to study them and expose their results. For average persons th... | 219,522 | [
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0.1878924,
0.04048302,
0.1002146,
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0.0340506,
0.1485717,
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0.04305024,
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0.1187711,
0.01666152,
0.4468966,
0.4334365,
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... |
[A case of sterility treated with sulpiride (author's transl)]. | Oligospermia associated with asthenia is a frequent cause of sterility. Sulpiride, which is a regulator of autonomic nervous system function, was prescribed alone in such a case and pregnancy resulted on two occasions. The relationship between the normal duration of spermatogenesis and the periods during which sulpirid... | 219,543 | [
-0.04707319,
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0.1197203,
0.167873,
0.2224456,
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0.2728747,
0.2396488,
0.0442677,
0.2844442,
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0.1186774,
0.04425592,
0.02109877,
0.1030473,
0.03194988,
0.15... |
[Isolated adenocarcinomatous transformation of uterine adenomyosis]. | A case of epithelia malignant changes in uterine adenomyosis is reported. The adenocarcinomatous transformation in uterine adenomyosis is rare. It is necessary to identify exactly the lesion to detect several histological tests specially the integrity of endometrium. An initial phase by atypic hyperplasia and the event... | 219,544 | [
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0.001079783,
0.4639597,
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-0.1248198,
... |
Enterovirus survey before and after poliomyelitis vaccination in Kuala Lumpur, Malaysia. | Stool samples from healthy children mainly of the low income group aged 0 to 7 years of age from five Maternal and Child Health Centres in Kuala Lumpur were obtained for isolation of enteroviruses. The specimens were collected before and after the mass vaccination given in the face of polio type 1 epidemic which starte... | 219,550 | [
-0.1851218,
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Noncoordinate expression of SV40-induced transformation and tumorigenicity in mouse cell hybrids. | Somatic mouse cells hybrids formed by fusion of nontumorigenic 3T3 closely related SV40-transformed SVT2 cells were analyzed in a study designed to probe the genetic basis of the multiple phenotypic changes induced by SV40 transformation. These hybrids showed noncoordinate expression of the transformation phenotype. Al... | 219,552 | [
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0.272767,
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Arteriovenous fistula and portal hypertension secondary to islet-cell tumor of the pancreas. | A case of portal hypertension secondary to an arteriovenous fistula in a pancreatic tumor is presented. Recurrent gastrointestinal hemorrhage prompted endoscopy which revealed esophageal varices and an abnormal papilla of Vater. Ultrasonography and arteriography were instrumental in demonstrating the nature of the path... | 219,555 | [
-0.05137182,
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... |
Epstein-Barr virus antibody responses and clinical illness in renal transplant recipients. | Among 88 renal transplant recipients evaluated for a change in Epstein-Barr virus (EBV) antibody status in the period after transplant, 22 showed a 4-fold rise and eight showed an 8-fold or greater rise in EBV antibody. Among the patients with an 8-fold or greater EBV ANTIBODY RISE, THE OCCURRENCE OF FEVER WAS FREQUENT... | 219,556 | [
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0.2326055,
0.2277405,
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0.09... |
Hepatoma with obstructive jaundice due to the migration of a tumor mass in the biliary tract: report of a successful resection. | A 51-year-old man underwent extended right lobectomy for hepatoma of the right lobe with obstructive jaundice due to migration of the tumor mass in the common and bilateral hepatic ducts. Severe jaundice amounting to 32.6 mg% and suppurative cholangitis were relieved by drainage through the cannulation into the hepatic... | 219,557 | [
-0.01216903,
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0.22272,
0.03728983,
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[Role of phospholipids in the realization of catecholamine action]. | The involvement of phospholipids into the function of the hormonoreactive system realizing the catecholamine action on the skeletal muscle metabolism was studied at different stages of chicken ontogenetic development. The phospholipase "D" treatment of the chicken muscle homogenate removed the epinephrine activating ef... | 219,571 | [
-0.0678776,
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Pseudotumor of kidney. | Hypertrophy of the renal columns of Bertin may present as a mass, at times difficult to distinguish from neoplasia or cyst. Herein, we present a case characterized by the inability of this lesion to absorb 99mTc DTPA (99mTechnetium diethylenetriaminepentaacetic acid) isotope on two separate renal studies. | 219,580 | [
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Study of host antigens in the envelopes of different myxo- and paramyxoviruses cultivated in the embryonated hen egg. | By immunoelectrophoretic analysis it was shown that different viruses--such as myxo- (influenza A0PR8) and paramyxoviruses (Sendai, SV5, NDV, mumps)--cultivated in the same host cells (chorioallantoic membranes) incorporate similar host antigens into their envelopes. The amount of host cell antigens incorporated into t... | 219,591 | [
-0.2696641,
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0.1835933,
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[Adaptation of the type I poliomyelitis virus to cotton rats]. | Adaptation of poliomyelitis virus type I (Mahoney strain) to the CNS of cotton rats which at the time of inoculation had been temporarily immunosuppressed with cyclophosphane is described. In the course of passages the virus properties were observed to change. The virus became pathogenic for cotton rats with normal imm... | 219,612 | [
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0.2143917,
0.04433466... |
[Effect of host cells on the course of chronic rabies virus infection in cell cultures]. | Different patterns of rabies virus infection were observed in BHK-21/13S and HEp-2 cell cultures at late stages of persistent infections. The infection of BHK-21/13S cells was characterized by periodical increases and declines in the portion of the antigen-containing cells (from 100% to less than 1%) and low infectivit... | 219,626 | [
-0.0001455681,
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... |
A micromorphological and histoenzymological study on the third ventricular ependyma of the teleost Clarias batrachus (L.). | The circum ventricular region of C. batrachus is highly vascular and the ependymal cells appear differently when stained with haematoxylin, silver impregnation and Golgi-Cox techniques. The ventricule has PAS and AF positive material and some ependymal cells themselves are PAS positive. Few AF positive peptidergic and ... | 219,633 | [
0.0750747,
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Neutralization of aggregated strains of enterovirus 71 and echovirus type 4 in RD and Vero or GMK-AH1 cells. | Strains of enterovirus 71 and echovirus type 4 containing aggregates which were poorly neutralized by antibody in cell lines of green monkey kidney origin such as Vero and GMK-AH1, were as easily neutralized as non-aggregated strains when grown in human RD cells, The explanation for this may be a lesser degree of aggre... | 219,662 | [
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-0.2178757,
... |
Prognostic value of a persistently positive technetium-99m stannous pyrophosphate myocardial scintigram after myocardial infarction. | Technetium-99m stannous pyrophosphate myocardial scintigrams were obtained in 138 clinically stable patients 32.7 +/- 47.3 weeks (range 6 to 260) after acute myocardial infarction. Of the 138 patients, 74 (54 percent) had a persistently positive scintigram. Patients with such a scintigram were more likely to have sever... | 219,674 | [
-0.128231,
0.2584188,
-0.2605471,
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0.1874994,
0.1907012,
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0.01152996,
0.2254579,
0.1274827,
0.1482393,
0.1568085,
-0.3091617,... |
Feedback-controlled dextrose infusion during surgical management of insulinomas. | Through the use of a feedback-controlled dextrose infusion system, we obtained continuous monitoring of the blood glucose level in a patient undergoing surgery for multiple pancreatic beta-cell tumors. In addition, this device infused dextrose at variable rates to maintain a predetermined euglycemic level of 90 mg/dl. ... | 219,691 | [
-0.227981,
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0.08257779,
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0.105362,
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0.2490889,
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0.04745295,
0.04701836,
-0.1885205,
0.1991726,
-0.05808665,
0.0309... |
Time course of the renal response to triiodothyronine in the rat. | Experiments were carried out to compare temporal changes in glomerular filtration rate (GFR), filtered Na+ load, and renal cortical (Na+ + K+)-adenosine triphosphatase (Na-K-ATPase) activity in the hypothyroid rat after administration of a single dose of triiodothyronine (T3) (50 microgram/100 g body wt). The cortex sh... | 219,708 | [
0.009048356,
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0.3878012,
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0.2666878,
0.1075836,
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0.2385219,
0.3170006,
0.4851333,
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0.01328706,
0.2107388,
0.199894,
-0.2716085,
0.2... |
Modifications of the immunofluorescence assay for feline leukemia virus group-specific antigens. | Observations and minor modifications are presented concerning the immunofluorescence assay for feline leukemia virus (FeLV) group-specific antigens (GSA) in blood cells of cats. Data are given regarding absorption of goat FeLV GSA antiserum in vivo in cats, absorption of the antiserum in vitro with feline blood cells, ... | 219,732 | [
0.05005158,
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0.02983801,
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0.3198833,
0.09373401,
0.01037031,
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... |
Growth of herpes simplex and cytomegalovirus in cultured human alveolar macrophages. | In laboratory animals, macrophages play a central role in controlling certain viral infections. Because the adult human lung is more susceptible to infection with cytomegalovirus than herpes simplex virus, we compared the replication of these two viruses in vitro in human alveolar macrophages. The growth of herpes simp... | 219,737 | [
-0.09407272,
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-0.05262083,
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0.3186281,
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0.09354917,
0.0... |
Regulation of gastric acid secretion. | The three stimulants of gastric acid secretion likely to have physiological roles in regulation of secretion are acetylcholine, gastrin, and histamine. Acetylcholine is released by vagal and intramucosal reflex stimulation, acting directly on the parietal cell. Gastrin is released by peptides and free amino acids in th... | 219,762 | [
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0.1491635,
0.2229269,
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-0.06261319,
0.07238831,
0.3602469,
-0.09200791,
-0.0643067... |
[Characterization and solubilization of specific growth hormone binding sites in the rat liver]. | The interaction of 125I-labeled human growth hormone (HGH) with microsomal membranes of female rat liver is a specific, saturable and reversible process; at saturation, about 0.9 picomoles of 125I-HGH are bound per mg of membrane proteins. Equilibrium is achieved after 90 minutes of incubation. The binding is dependent... | 219,801 | [
-0.1255139,
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0.08410457,
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0.2162673,
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0.1476148,
0.02470613,
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0.03063737,
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0.07327906,
0.2158027,
0.422791,
0.2149892,
-0.21498... |
Cytochemical studies of ameloblasts and the surface layer of enamel of the rat incisor at the maturation stage. | In order to elucidate the cytochemical properties of the membranous structure between enamel and ameloblasts of the rat incisor at the maturation stage, chromic phosphotungstic acid (Cr-PTA) and periodic acid-silver methenamine (PA-silver) techniques for electron microscopy were employed in combination with a digestion... | 219,803 | [
0.02831983,
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0.148878,
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0.3608533,
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0.3516024,
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0.2857611,
0.08521742,
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0.2290696,
0.1861808,
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0.63444,
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-0.03888453,
0.... |
Avian adenoviruses--distribution of infection in commercial flocks of fowls in Argentina. | Group-specific avian adenovirus antibodies were surveyed in broiler, layer, and breeder chickens in three poultry-producing areas of Argentina: north, middle, and south. The method used was the agar double-immunodiffusion test. Of the flocks examined, 89% had antibodies to avian adenovirus, with the percentages higher ... | 219,837 | [
-0.07512923,
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0.0980904,
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0.2860938,
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0.06384965,
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0.1055409,
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0.1383234,
0.2186514,
-0.03951037,
-0.14... |
Effects of food deprivation on ketonaemia, ketogenesis and hepatic intermediary metabolism in the non-lactating dairy cow. | 1. The aim of this work was to investigate why non-lactating dairy cows are less susceptible to the development of ketonaemia during food deprivation than are dairy cows in early lactation. 2. The first experiment (Expt. A) consisted of determining the effect of 6 days of food deprivation on the concentrations of keton... | 219,850 | [
-0.09929348,
-0.005531817,
0.1478923,
0.193072,
0.3002599,
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0.02384808,
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0.1266388,
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0.1039215,
0.2754189,
0.1506542,
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0.03274769,
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0.2350482,
-0.3674088,
-0.2970763,
-0.2549268,
0.3842308,
0.3083804,
... |
How does insulin stimulate glycogen synthesis? | One of the important effects of insulin on intracellular metabolism is its ability to stimulate the synthesis of glycogen in muscle and liver. It does this by promoting a net decrease in the extent of phosphorylation of glycogen synthase, the rate-limiting enzyme in the pathway of glycogen synthesis, which increases it... | 219,866 | [
-0.170417,
-0.09990847,
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0.1165008,
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0.2292649,
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0.00411378,
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-0.1914146,
-0.02574976,
-0.06619015,
0.2014847,
0.3201709,
0.1338821,
-0.02484182... |
Hormonal control of adipose-tissue lipolysis. | Adipose-tissue triacylglycerol is the major energy store in man. The physiological importance and biochemical mechanism of the hormonal control of lipolysis in white adipose tissue is reviewed. Rates of lipolysis and fatty acid release observed when adipose tissue is incubated in vitro are compared with rates of triacy... | 219,867 | [
-0.1233225,
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-0.3246062,
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0.01800146,
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-0.2470554,
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0.09424177,
0.1206188,
0.09608919,
-0.385161... |
The purification of nuclease-free T4-RNA ligase. | RNA ligase has been highly purified in good yields from bacteriophage T4-infected Escherichia coli by a rapid and reproducible procedure. The enzyme is free of phosphomonoesterase and ribonuclease activities and is therefore suitable for the synthesis of oligoribonucleotides and for the labeling of the 3'-terminus of R... | 219,895 | [
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0.1157228,
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0.09595901,
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0.09341538,
0.1994214,
0.3335,
0.02087912,
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0.2606521,
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-0.00955274,
0.1019214,
0.0464716,
0.4452723,
-0.2484228,
-0.435741,
0.115... |
Bone matrix studies. Influences of parathyroid extract, calcitonin, and cholecalciferol and of rickets and its treatment. | Bones from young rats were incubated with radioactive glucosamine and proline. The concentrations and specific activities of matrix glycosaminoglycan fractions, prepared by a cetylpyridinium chloride method, and the specific activity of insoluble collagen hydroxyproline were determined. Acute parathyroid extract treatm... | 219,901 | [
-0.2113651,
-0.05224329,
-0.1202102,
0.3766568,
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-0.1123652,
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0.1532462,
0.3002859,
0.05861446,
0.3924456,
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0.008281549,
0.289057,
-0.1565103,
-0.001779281,
-0.09275797,
0.131663,
0.1735229,
0.1936067,
-0.1109292... |
Studies of the plasma membrane during maturation of the mammalian erythrocyte. | Plasma membranes were obtained from a homogeneous population of rabbit red blood cells at different maturation periods. Minor modifications in membrane proteins and membrane phospholipids and significant decreases in membrane glycoproteins and total lipids were observed with the age of the cell. The ouabain inhibited (... | 219,911 | [
-0.06753553,
0.1090887,
-0.4076223,
-0.1504373,
-0.01771123,
-0.2242953,
-0.01465802,
0.3234049,
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0.2089784,
0.3249198,
0.2416328,
-0.01378715,
-0.02070508,
-0.3439986,
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-0.4616119,
0.02552565,
-0.09833446,
0.08964168,
0.6950771,
0.2793604,
-0.1657... |
Effects of concanavalin A on 5-hydroxytryptamine uptake by rabbit blood platelets and on their ultrastructure. | 1. Effects of concanavalin A (Con A) and other lectins on 5-hydroxytryptamine (5-HT) uptake by rabbit blood platelets and on their ultrastructure were studied. 2. Uptake of [3H]-5-HT by platelets was decreased by application of Con A, E-PHA (lectin from Phaseolus vulgaris) and lentil-PHA (lectin from Lens culinaris), b... | 219,926 | [
0.01727945,
-0.08252377,
0.09626406,
0.08208936,
-0.08013864,
-0.3134392,
-0.01129164,
0.3570493,
-0.187692,
0.5306033,
0.2701961,
0.4262536,
0.2008066,
0.1695679,
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0.07531025,
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0.1787952,
0.1702596,
0.3970047,
0.4475094,
-0.2817076,
-0... |
The effects of opioid drugs and of lithium on steroidogenesis in rat adrenal cell suspensions. | 1. The effects of opioid drugs and of Na+ replacement on steroidogenesis in rat adrenal cell suspensions were investigated. 2. In medium containing normal Na+ (156 mM), opioid antagonists but not opioid agonists reduced the steroidogenic response to adrenocorticotrophic hormone1-24 (ACTH1-24) but not to dibutyryl adeno... | 219,928 | [
0.128891,
0.09145232,
-0.3838744,
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-0.1024357,
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-0.3031566,
0.08350747,
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0.07206809,
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0.1152624,
0.2308969,
0.3359644,
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0.1712878,
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0.1232737,
0.1337471,
0.2277662,
0.5126733,
0.006179051,
-0.1834565,
0.3... |
Relation between plasma hormone profiles, symptoms, and response to oestrogen treatment in women approaching the menopause. | Out of a consecutive series of 300 patients seen at a menopause clinic, 82 complained of symptoms generally associated with the climacteric, although they were still menstruating. Vasomotor disturbances were absent in 42 of these patients (group 1) and present in 40 (group 2). Headaches, insomnia, and dyspareunia were ... | 219,937 | [
-0.09130521,
0.2330659,
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-0.1563977,
-0.003170456,
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0.09401695,
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0.04854819,
0.3130733,
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0.1856028,
-0.02238827,
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-0.255672,
0.3740171,
0.06255616,
0.1436247,
0.1070109,
0.1844819,
-0.03051313,... |
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