title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Basal levels of pituitary ACTH and plasma corticosterone after complete or frontal cuts around medial basal hypothalamus. | Plasma corticosterone level and corticotropin (ACTH) content of the anterior pituitary (AP) were measured after various cuts around the medial basal hypothalamus (MBH). Seven to eight days after placing a complete cut around MBH there was no change in plasma corticosterone or ACTH content of AP; the slight rise in ACTH... | 220,012 | [
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Somatostatin secretion from monolayer cultures of neonatal rat pancreas. | Monolayer cultures of neonatal rat pancreas have been characterized as an in vitro system for studying SRIF secretion. Marked 12- and 6-fold potentiation of SRIF release occurred with N-2-O-dibutyryl cAMP monosodium salt and theophylline, respectively. High glucose (300 mg/dl) stimulated SRIF release, whereas galactose... | 220,017 | [
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Distribution of the messenger RNA coding for the common precursor of corticotropin and beta-lipotropin within the bovine pituitary. | The distribution of the mRNA coding for the common precursor of corticotropin and beta-lipotropin among different parts of the bovine pituitary has been investigated by quantifying the mRNA activity with the use of a cell-free protein-synthesizing system. The results obtained have demonstrated that this mRNA activity i... | 220,044 | [
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Isolation of a sarcoma virus from a spontaneous chicken tumor. | A spontaneous tumor was obtained from a hen of White-Leghorn stock raised in a local farm in Yamaguchi City, in December 1973. The tumor had characteristics of fibro- or myxofibro-sarcoma and could be maintained by transplantation in chickens of similar flocks. This tumor was proved to produce sarcoma virus at 33rd pas... | 220,128 | [
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Primary liver tumors in the pediatric age group: an angiographic challenge. | Eleven children, ranging in age from three months to fifteen years, with primary liver tumors were examined by large volume direct magnification arteriography (2.5--3 ml of contrast material per 1 kg body weight for a single selective study). The following tumors were found: hepatoblastoma (1), hepatocellular carcinoma... | 220,163 | [
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Characteristics of a low-molecular-weight factor extracted from mouse tumors that affects in vitro properties of macrophages. | A dialysable low-molecular-weight factor capable of affecting in vitro properties of macrophages was extracted from four different mouse tumors. This factor not only modulates closely related properties of peritoneal macrophages such as spreading and migration but also inhibits lipopolysaccharde-induced tumoricidal ac... | 220,197 | [
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Reproducibility and relation to specific and non-specific anti-tumor resistance of the tumor "sneaking through" phenomenon. | The reproducibility and immunological specificity of the tumor "sneaking through" phenomenon and enhancement of tumor growth were studied in syngeneic and random-bred Syrian hamsters by means of a quantitative modification of the transplantation test. After primary challenge the phenomenon was neither observed in norma... | 220,202 | [
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Control of cyclic adenosine 3',5'-monophosphate levels by depolarizing agents in fungi. | It has been reported that diverse treatments which depolarize the plasma membrane of Neurospora crassa produce rapid increases in cyclic adenosine 3',5'-monophosphate (cyclic AMP) levels. In the current study, membrane active antibiotics, which are known or putative depolarizing agents, were found to produce similar cy... | 220,213 | [
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Comparative solvent perturbation of horse heart cytochrome c and Rhodospirillum rubrum cytochrome c2. | The extent of exposure of heme to solvent in horse heart cytochrome c and Rhodospirillum rubrum c2 was investigated to determine whether a correlation exists between the properties of these oxidation-reduction proteins and their heme environments. Solvent perturbation absorption difference spectra were measured using e... | 220,233 | [
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Heme-associated subunit complex of cytochrome c oxidase identified by a new two-dimensional gel electrophoresis. | A Novel two-dimensional system (isoelectric focusing in the first dimension and sodium dodecyl sulfate-urea electrophoresis in the second) was used to determine the pI values of beef heart subunits of cytochrome c oxidase. The results identified a heme-associated complex of Subunits I, II, and IV. Conditions mitigate a... | 220,237 | [
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Regulation of phosphatidylcholine metabolism by cyclic AMP in a model alveolar type 2 cell line. | The influence of cyclic AMP on the metabolism of phosphatidylcholine, the major component of pulmonary surfactant was examined in a cell line (A549) with type 2 pneumonocyte characteristics. It was found that cyclic AMP increased both the total amount of phosphatidylcholine and disaturated phosphatidylcholine as well a... | 220,241 | [
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Purification of a cyclic nucleotide phosphodiesterase from bovine brain using blue dextran-Sepharose chromatography. | The soluble high Km form of cyclic nucleotide phosphodiesterase (EC 3.4.1.17) was purified over 2000-fold from bovine brain homogenates principally using blue dextran-Sepharose chromatography. The purified protein has a specific enzymic activity of 167 units/mg and appears homogeneous when examined by polyacrylamide ge... | 220,243 | [
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Multiple malignant Spiegler tumors with brachydactyly and racket-nails. Light and electron microscopic study. | Multiple malignant Spiegler tumors were observed on the scalp of a 67-year-old female patient with brachydactyly and racket-nails affecting all fingers of both hands. The occurrence of similar clinical features in the family of the patient is suggestive of a hereditary disorder. The light and electron microscopical fin... | 220,286 | [
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Effects of the aflatoxins on ATPase activities in mouse and rat liver. | The effects of the aflatoxins on ATPase activities in mouse and rat tissues were investigated in vitro. The hepatic oligomycin-sensitive (O.S.) Mg++ ATPase was inhibited significantly. The order of inhibition was G1 greater than B1 greater than G2 greater than B2. Mouse O.S. Mg++ ATPase was more sensitive than the corr... | 220,299 | [
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Isolation of a cytotoxin-enterotoxin from Entamoeba histolytica. | A heat-labile material with cytotoxic and enterotoxic activities was isolated from axenically cultivated Entamoeba histolytica. The cytotoxin-enterotoxin was partially purified from the particulate-free supernatant of sonicated trophozoites by ammonium sulfate precipitation and gel filtration. Cytotoxic activity, assay... | 220,331 | [
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Seroimmunity to polioviruses in U.S. Army recruits. | Titers of neutralizing antibody to poliovirus types 1, 2, and 3 were determined for serum specimens obtained from 268 U.S. Army recruits. Among those tested, 20.9% lacked neutralizing antibody to one or more types of poliovirus, and 1.1% lacked antibody to all three types. An analysis of demographic data showed that ag... | 220,335 | [
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Complement-enhanced neutralizing antibody response to varicella-zoster virus. | Humoral immunity following infection with varicella-zoster virus (VZV) was evaluated by a complement-enhanced neutralization test. The specificity of the test was examined and its sensitivity compared with that of the assay which measures antibody to VZV-induced membrane antigen (FAMA). Generally, the titer of neurtali... | 220,336 | [
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Evaluation of indirect hemagglutination and its inhibition in the differentiation between antibodies to herpes simplex virus types 1 and 2 for seroepidemiologic studies: use of a II/I index threshold of 85 and an assay of type-specific antibodies. | Two parameters, a II/I index threshold value of 85 and an assay of type-specific antibodies to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), were assessed, for seroepidemiologic purposes, for their efficacy in the establishment of past infections with HSV-1 and HSV-2 as indicated by the results of tests for i... | 220,339 | [
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The cholesterol turnover, synthesis, and absorption in two sisters with familial hypercholesterolemia (type IIa). | To explore the mechanisms of the profound plasma cholesterol elevations in familial homozygous hypercholesterolemia (type IIa), cholesterol turnover, sterol balance, cholesterol absorption, and low density lipoprotein studies were carried out under controlled dietary conditions in two sisters (aged 13 and 16). Choleste... | 220,354 | [
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Essential fatty acid deficiency and adrenal cortical function in vitro. | Adrenocortical cells were prepared from rats maintained on essential fatty acid-deficient diets and control litter mates. Cells from control rats had high concentrations of essential fatty acids in the cholesteryl ester fraction of which approximately 22% was arachidonate. In contrast, cells from EFA-deficient rats had... | 220,357 | [
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Phagosome-lysosome fusion and cyclic adenosine 3':5'-monophosphate in macrophages infected with Mycobacterium microti, Mycobacterium bovis BCG or Mycobacterium lepraemurium. | When ingested by mouse peritoneal macrophage monolayers, live Mycobacterium microti caused a sustained increase in monolayer cyclic AMP content and fusion of lysosomes with the bacterium-containing phagosomes was impaired. Ingested live M. bovis BCG caused a transient increase in cyclic AMP and the defect in phagolysos... | 220,379 | [
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Contribution of the locus coeruleus to the adrenergic innervation of the rat spinal cord: a biochemical study. | The possible existence and magnitude of a noradrenergic innervation from the locus coeruleus (LC) to the spinal cord was investigated in the rat with various techniques. Horseradish peroxidase, injected into the lumbar spinal cord produced heavy labelling of presumably noradrenaline (NA)-containing neurons in the ventr... | 220,381 | [
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Derangement of neuronal migration in a child with multiple congenital anomalies, two congenital neoplasms, without apparent chromosomal abnormalities. | A live-born male infant with multiple severe abnormalities, two congenital neoplasms, a neuroblastoma and nephroblastoma, and without apparent chromosomal abnormalities, is described. The neuropathologic findings were a holoprosencephalic type defect with disturbance of neuronal migration to the cortical plate. Compari... | 220,395 | [
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Changes in total and quantal release of acetylcholine in the mouse diaphragm during activation and inhibition of membrane ATPase. | 1. Acetylcholine (ACh) released from mouse diaphragm was gel filtrated and estimated by bio-assay and compared with electrophysiologically measured quantal release, expressed either as frequency of miniature end-plate potentials or quantum content of end-plate potentials. 2. Activation of Na+-K+-dependent membrane ATPa... | 220,410 | [
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Spinal cord compression from metastatic breast carcinoma: treatment by radiation therapy alone. | There are few reports in the medical literature of treatment of compression of the spinal cord by the use of radiation therapy alone. Laminectomy has been the standard procedure to relieve compression of the spinal cord and should be performed within 48 hours of initial symptoms. In this patient, radiation therapy was ... | 220,430 | [
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Requirement for guanosine triphosphate in the activation of adenylate cyclase by cholera toxin. | The activation of adenylate cyclase in lysed pigeon erythrocytes requires, among several cofactors, a nucleotide which may be ATP, GTP, or many other triphosphates. However, after removal of endogenous nucleotides by gel filtration or by adsorption onto charcoal the requirement can be met only by GTP, or an analog of G... | 220,466 | [
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Kidney stones: various forms and treatment. | Calcium urolithasis is not a homogeneous entity, but is a result of many etiologies, with different physicochemical and physiological backgrounds. This diversity of presentation requires an appreciation of specific diagnostic criteria, and a selection of an appropriate treatment regimen for each cause. | 220,549 | [
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Preliminary characterization of viruses isolated from cases of epididymitis and vaginitis in cattle. | Twelve slow-growing virus isolates propagated in tissue culture from cattle with epididymitis and vaginitis were identified as herpes viruses by virtue of their biological, physicochemical and morphological characteristics. None of the 12 virus strains proved to be serologically related to the infectious pustular vulvo... | 220,578 | [
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... |
Large scale, analytical method for isolating basal lateral plasma membranes from rat duodenum. | A procedure is described for obtaining large amounts of basal lateral plasma membranes from the rat duodenal epithelium. The yield is approximately 50%, and the purification factor is 18; preparations from 25 rats routinely contain 100 mg of protein. The procedure depends on mild homogenization with a nitrogen cavitati... | 220,601 | [
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Coupling between oxidation state and hydrogen bond conformation in heme proteins. | In all heme proteins for which crystal structures are available, the N(epsilon) of a histidyl residue is bonded to the heme iron and N(delta) is hydrogen bonded to a carbonyl oxygen of the peptide backbone. We investigate here the possibility that a change in oxidation state of the iron or a change in the geometry of t... | 220,604 | [
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0.0007380464,
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Adenylate cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids. | Serotonin activates adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] of NCB-20 neuroblastoma--brain hybrid cells with an activation constant of 530 nM, but has little or no effect on cellular cyclic AMP or cyclic GMP content of NIE-115 neuroblastoma or NG108-15 hybrid cells. In homogenates of NCB-20 ... | 220,607 | [
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Immunopathological mechanisms in rheumatoid arthritis at the dual interface of the synovial membrane: the joint cavity and the pannus. | The significance of immune responses is examined in relation to clinicopathological changes in the rheumatoid joint and the concept of a dual site of action is developed. In the joint cavity interaction between immune complexes and complement is central to the phenomena observed, which depend on the generation of chemo... | 220,699 | [
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Metabolic and cardiovascular effects of salbutamol in atopic subjects with and without asthma. | An intravenous injection of 100 microgram salbutamol sulphate was administered to a group of atopic asthmatics and a group of atopic control subjects without asthma. There was no difference in the metabolic and cardiovascular reponses of the two groups. | 220,703 | [
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[Abrikossof tumor in the esophagus]. | Among the benign tumours of the oesophagus, the discovery of an Abrikossof tumour is exceptional. Although modern methods of investigation now permit recognition of this tumour and suspect its benign nature, only histology permits one to determine its precise nature, either by biopsy or by frozen section. Histogenetica... | 220,720 | [
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[Long-term therapy of osteoarthritis of the hip and the knee by sulindac (a cooperative trial in general practice) (author's transl)]. | Long-term trial of sulindac (in general practice): 2,040 patients with osteoarthritis of the hip or of the knee been treated, 86,5% of them have been following the treatment for one year. This trial let us pointing out the non-improverishment of effectiveness of sulindac and the keepint of its good tolerance for long t... | 220,728 | [
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Metastatic carcinoma with carcinocythemia mimicking leukemia. | Carcinoma metastatic to the bone marrow may present with peripheral blood and bone marrow changes and a clinical picture difficult to distinguish from leukemia. It is important to make an accurate diagnosis since the management is different. We have described a patient with circulating primitive cells and diffuse marro... | 220,736 | [
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Respiratory viral infection and wheezy bronchitis in childhood. | The role of respiratory viral infection in wheezy bronchitis was studied in 163 children, aged 0-12 years, in a London general practice. Virological investigations were also performed when these same children had acute upper respiratory illness without wheeze. A virus was isolated in 146 (26.4%) of 554 episodes of whee... | 220,747 | [
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... |
[Relation of urinary excretion of cholesterol in cancer patients to certain hormonal-metabolic parameters and the effect of drugs on this relation]. | Excretion of cholesterol with urine was studied using gas chromatography in healthy persons, in patients with cancer of mammary glands, fibroadenoma, lung carcinoma and in patients with beningn processes in lungs. Cholesterol excretion was not increased in patients with the malignant tumors studied. In patients with th... | 220,799 | [
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0.5076136,
0.4534452,
0.001939735,
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... |
[Hydrocyanic acid content in cerals and cereal products]. | In the above paper for the first time a systematic study of the amount of hydrocyanic acid in grains and cereal products is reported. Among 24 analysed wheat, rye, maize and oats types, the presence of hydrocyanic acid could be identified in 19 cases in their Karyopses. Similar is the result with 28 among 31 analysed c... | 220,807 | [
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... |
[Hemodynamics in patients suffering from hyperkinetic cardiac syndromes and in normal persons under psychological stress before and after treatment with propranolol (author's transl)]. | In patients with hyperkinetic heart syndrome we found at rest a higher heart rate, a higher stroke volume and a higher cardiac output than in normal volunteers. Therefore blood pressure is high although peripheral resistance is lower than in normals. Similar circulatory differences were found under conditions of mental... | 220,809 | [
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... |
[Clinical value of studying strength-duration curves using intramuscular (needle) electrodes in patients with lumbosacral radicular syndromes]. | The paper deals with the results of a force-duration curve comparative study which was accomplished-in 20 patients with the aid of usual skin and acupunctural point electrodes. The spicular needle introduced painlessly into the muscles studied, served as an active electrode connected by a fine cord to a clamp of the el... | 220,825 | [
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... |
A prospective study on the incidence and significance of congenital cytomegalovirus infection. | Screening of 3060 neonates for congenital cytomegalovirus (CMV) infection by virus excretion in the urine showed an overall incidence of 0.4%. The incidence was about 1% for mothers between 16 and 25 years and only 0.2% for mothers between 25 and 35. No mothers over 35 years of age gave birth to congenitally infected i... | 220,837 | [
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Multiple pituitary hormone deficiencies in eight siblings of one Jewish Moroccan family. | In a Jewish Moroccan inbred family, 8 of 12 siblings were found to have multiple deficiencies of pituitary hormones, including GH, TSH and gonadotrophins. The parents showed no deficiency and are in good health, as are the other 4 siblings. The investigations carried out indicate that in this family the etiology is her... | 220,839 | [
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... |
Apomorphine stereotypies and transmitter mechanisms in the striatum. I. Changes in the apomorphine stereotypies caused by drugs acting on the GABA-ergic, dopaminergic and cholinergic transmission. | Experiments on male albino mice were carried out in order to determine the effects of drugs connecting with the GABA-ergic, dopaminergic and cholinergic transmission, on apomorphine stereotypies. The agents acting on GABA-ergic transmission are found to reduce the intensity of apomorphine stereotypies in the following ... | 220,843 | [
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... |
Altered adrenergic activity in coronary arterial spasm: insight into mechanism based on study of coronary hemodynamics and the electrocardiogram. | To elucidate the pathophysiologic mechanism of coronary arterial spasm, the hypothesis was examined that underlying alterations in sympathetic activity may account for this syndrome in some patients. Observations were directed to alterations in coronary arterial hemodynamics and the electrocardiogram. Spasm of the left... | 220,865 | [
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... |
Induced abortion and congenital malformations in offspring of subsequent pregnancies. | A case-control (n = 1427 and 3001, respectively) study in Connecticut found no relationship between delivery of an infant with congenital malformations and overall previous experience of induced abortion (odds ratio (o) = 0.9, 95% CL = 0.7, 1.1). Delivery of a congenitally malformed infant was also unrelated to: 1)abor... | 220,871 | [
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0.3... |
ProACTH: use for early detection of lung cancer. | ProACTH was identified by radioimmunoassay and column chromatography in extracts of 38 lung carcinomas. One hundred patients were evaluated because of abnormalities on chest roentgenograms; 53 (72 per cent) of 74 with lung cancers had increased plasma ACTH immunoreactivity; all 26 with benign abnormalities had normal A... | 220,873 | [
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Peripheral rheumatoid ulceration and evidence for conjunctival collagenase production. | Two patients with rheumatoid arthritis and peripheral corneal ulcerations were successfully treated by conjunctival resection. The tissues removed were assayed by a variation of the radial diffusion method for tissue collagenases. We used an agarose matrix containing lathyritic rat skin collagen. Wells 3 mm deep were p... | 220,878 | [
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Research and development of naltrexone: a new narcotic antagonist. | The author reviews the history of federally supported research in the field of narcotic antagonist therapy, focusing on social, political, and governmental issues. He describes the criteria for establishing an optimum narcotic antagonist, the legal guidelines for drug development, and the currently available narcotic a... | 220,890 | [
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[Gonadoblastoma and overgrowing dysgerminoma in Turner mosaicism [45, XO/46, Xi (Xq)] (author's transl)]. | It is well established that the Y-chromosome is associated with germ cell tumor development. There is a considerable tumour risk in XY- and XY/XO-gonadal dysgenesis. In the absence of Y-chromosome germ cell tumours are extremely rare. The history of a patient with 45 XO/46 Xi (Xq)-karyotype is presented, who had a gona... | 220,922 | [
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0.03889771,
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0.1289185,
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... |
Serological identification of viral and virus-related antigens on DBA/2 mouse leukemia lymphocytes. | Allogenic, semisyngeneic and syngeneic sera of animals immunized with ML-positive leukemia L1210 cells, besides anti-ML antibodies, contain antibodies which react with Gross cellular surface antigen. ML antigen and Gross cellular surface antigen were shown by the immunoferritin test in electron microscopy, and by the b... | 220,930 | [
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0.06564839,
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... |
Rat interferons. VI. Heterologous interferon in the treatment of viral infections. | In previous studies in vitro we demonstrated the protection of mouse cells against viral infections by rat interferon. In continuation, the present paper reports results of a study designed to confirm this heterospecific activity of rat interferon in vivo. Experiments were carried out with mice of the inbred 129/AoBoy ... | 220,932 | [
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0.1058329,
... |
Structure and metabolism of sulphated glycosaminoglycans in cultures of human fibroblasts. Structural characteristics of co-polymeric galactosaminoglycans in sequential extracts of fibroblasts during pulse-chase experiments. | 1. Human embryonic lung and skin fibroblasts were allowed to incorporate 32SO42- or 35SO42- and D-[1-3H]glucosamine. After removal of the medium the monolayer was subjected to sequential extractions by using EDTA, brief trypsin digestion, extraction with dithiothreitol ofllowed by freeze--thawing and extraction with tr... | 220,958 | [
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The effects of lipid phase transitions on the interaction of mitochondrial NADH--ubiquinone oxidoreductase with ubiquinol--cytochrome c oxidoreductase. | 1. The endogenous phosphatidylcholine and phosphatidylethanolamine of Complexes I and III from bovine heart mitochondria may be completely replaced with 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine with at least partial retention of activity. 2. The lipid-replaced enzymes associate in 1:1 molar ratio to give a Compl... | 220,964 | [
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0.... |
Central nervous system lupus erythematosus: measurement of cerebrospinal fluid cyclic GMP and other clinical markers of disease activity. | Cyclic-GMP (C-GMP), a normal constituent of the central nervous system, was found to be present in increased amounts in the cerebrospinal fluid (CSF) of systemic lupus erythematosus (SLE) patients with active neurologic disease. Twenty-four CSF samples from 17 patients with SLE were evaluated for C-GMP concentration by... | 220,988 | [
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0.3166014,
-0.05440826,
-0.02170... |
The action of silybin on the mouse liver in alpha-amanitine poisoning. | Histochemical and histoenzymological studies were carried out on liver slices from mice which had received alpha-amanitine two days previously, some of which had been treated with silybin, and from control mice. The toxin produced certain changes in the activity of the enzymes involved in different metabolic processes,... | 220,990 | [
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The multiplicity and stoichiometry of the prosthetic groups in QH2: cytochrome c oxidoreductase as studied by EPR. | 1. The EPR signal in the g = 2 region of the reduced QH2: cytochrome c oxidoreductase as present in submitochondrial particles and the isolated enzyme is an overlap of two signals in a 1 : 1 weighted ratio. Both signals are due to [2Fe-2S]+1 centers. 2. From the signal intensity it is computed that the concentration of... | 221,014 | [
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... |
Characterization of low density lipoprotein-like particle in the human aorta from grossly normal and atherosclerotic regions. | Physical and chemical criteria of lipoproteins containing apolipoprotein B, extracted from human aortic intima, were compared with those of plasma low density lipoproteins (LDL). Homogenates of grossly normal intima and advanced atherosclerotic lesions were subjected to differential ultracentrifugation to isolate a d =... | 221,034 | [
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Protein phosphorylation in rat caudate homogenate: stimulatory effects of dopamine and enhancement of dopamine response following 6-hydroxydopamine treatment. | Dopamine (3-hydroxytyramine) stimulates the incorporation of 32P into proteins endogenous to a homogenate of rat caudate nucleus when 10 microM [gamma-32P]-ATP is used as a substrate following preincubation with 400 microM ATP. The increase in 32P incorporation has pharmacological characteristics similar to caudate tis... | 221,039 | [
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... |
Interaction between neuronal amine uptake and prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleen. | Experiments were performed to determine the conditions in which norepinephrine release from adrenergic nerve terminals in smooth muscle from canine blood vessels and spleen might be inhibited by prejunctional alpha-adrenergic receptor activation. Strips of aorta, mesenteric and splenic arteries, splenic capsule and por... | 221,058 | [
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Effect of nerve activity on the in vivo release of [3H]serotonin continuously formed from L-[3H]tryptophan in the caudate nucleus of the cat. | A new isotopic approach has been developed to study the in vivo release of serotonin (5-HT). 'Encéphale isolé' cats were implanted with a push-pull cannula in the ventrocaudal part of the head of the caudate nucleus to estimate the release of [3H]5-HT continuously synthesized from L-[3H]tryptophan. Both [3H]5-HT and [3... | 221,075 | [
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0.093... |
Adenosarcoma of uterus and ovary: a clinicopathologic study of two cases. | We report the clinical and pathologic features of two cases of adenosarcoma. Our first case occurred in the ovary of a 51-year-old woman with extensive pelvic involvement. She was treated vigorously with radiation and chemotherapy and at the present time almost 9 years later the patient is free of disease. This represe... | 221,090 | [
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Increased cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in the epidermis of phorbol ester-treated mouse skin and in papillomas. | The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, produced a 2- to 3-fold increase in the activity of both the low- and high-affinity forms of cyclic adenosine 3':5'-monophosphate phosphodiesterase activity 13 hr after application to mouse skin. The magnitude of the enzyme induction correlated with the t... | 221,099 | [
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Reversal by glucocorticoid hormones of the loss of a fibronectin and probollagen matrix around transformed human cells. | Confluent cultured human skin fibroblasts had an extracellular fibrillar matrix of fibronectin and procollagen. Human skin fibroblasts transformed by SV40 did not have such a matrix. Treatment of transformed fibroblasts with 10(-5) to 10(-8) M dexamethasone and 10(-5) to 10(-7) M cortisol, but not testosterone or proge... | 221,101 | [
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Cyclic adenosine 3':5'-monophosphate and protein kinase activity in insulin-dependent and -independent mammary tumors. | Approximately 70% of primary 7,12-dimethylbenz(alpha)-anthracene-induced mammary tumors regressed when (tumor-bearing) rats were made diabetic after treatment with streptozotocin. In the intact animal, cyclic adenosine 3':5"-monophosphate (cAMP) levels of tumors that regressed following the induction of diabetes were i... | 221,106 | [
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A comparison of angiotensinase and placental leucine aminopeptidase during normal pregnancy. | 1. Serum leucine aminopeptidase activity measured by its action on hydrolysis of L-leucyl-beta-naphthylamide was increased progressively as pregnancy advanced. Angiotensinase activity determined by bioasaay showed parallel increase during normal pregnancy. 2. The effects of heat treatment and L-methionine on the activi... | 221,135 | [
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The use of the electroencephalogram in patients admitted for alcohol abuse with seizures. | This study of 174 seizure presenting alcohol abusers revealed that the EEG is overwhelmingly normal by visual inspection. When the EEG is abnormal, however, usefulness is significant. The probable EEG findings in this group are presented and discussed here both clinically and experimentally. The literature is reviewed ... | 221,140 | [
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Subcellular localization of thyroxine and reverse triiodothyronine outer ring monodeiodinating activities. | In order to examine the subcellular localization of outer ring T4- and rT3-monodeiodinating activities, nuclear, mitochondrial, microsomal, cytosol, and plasma membrane fractions of rat liver homogenate were incubated with either T4 or rT3 in phosphate buffer (pH 7.35) in the presence of 2 mM dithiothreitol for 15 min ... | 221,175 | [
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Cyclic nucleotide-dependent protein kinase modulators in thyroid tissue. | A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substra... | 221,200 | [
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Titration of total binding sites for growth hormone in rabbit liver. Quantitative modifications of these sites during pregnancy. | The present work outlines various kinetic parameters of the interaction between bGH (bovine growth hormone) and a receptor located on the membranes of rabbit liver. A dissociation procedure, which strips the hormone off its receptor has been worked out, by varying MgCl2 concentrations and times of contact; exposure to ... | 221,284 | [
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Use of reflected green light for specific identification of islets in vitro after collagenase isolation. | A simple technique is described that permits specific identification in vitro of isolated islets as contrasted with samll lymph nodes. | 221,296 | [
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RNA synthesis of vesicular stomatitis virus. VIII. Oligonucleotides of the structural genes and mRNA. | The single-stranded RNA genome of vesicular stomatitis virus (VSV, Indiana serotype, San Juan strain) yields approx. 75 RNase T1-resistant oligonucleotides ranging in size from 10 to 50 bases. Each of the five structural genes, isolated as duplex RNA molecules hybridized to complementary mRNA, contains two or more of t... | 221,308 | [
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Cushing's syndrome: a tripartite entity. | The three distinct etiologies of Cushing's syndrome usually reflect the presence of a neoplasm, most often but not necessarily of the pituitary, and all ultimately result in hypercortisolism. Recent advances in diagnosis and treatment have vastly improved the outlook for many patients. Several therapeutic options are o... | 221,317 | [
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Physical mapping of herpes simplex virus-coded functions and polypeptides by marker rescue and analysis of HSV-1/HSV-2 intertypic recombinants. | A number of temperature-sensitive (ts) mutants and one pyrimidine deoxyribonucleoside kinase-deficient mutant of herpes simplex virus (HSV), have been located on the physical map of the genome by means of marker rescue experiments and by the analysis of the crossover points in intertypic recombinants between HSV types ... | 221,322 | [
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Analysis of herpes simplex virus low molecular-weight native proteins by polyacrylamide gel electrofocusing. | This communication has demonstrated the potential application of gel electrofocusing for the isolation and further characterization of HSV-2 native proteins. At least eight major HSV-2 specific proteins with characteristic isoelectric points could be reproducibly resolved by gel isoelectric focusing. Their isoelectric ... | 221,328 | [
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Cell DNA induction by human cytomegalovirus. | The studies presented indicate that in cells pretreated with IUDR: (1) a temporal relationship exists between CMV and cell DNA synthesis; (2) in cells pretreated with IUDR only a fraction of the cell genome is induced by the virus to replicate; and (3) cell DNA induced by the virus to replicate represents unique rather... | 221,342 | [
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... |
The use of intertypic recombinants for analysis of gene organization in herpes simplex virus. | Analysis of the DNA sequence arrangement and polypeptides specified by 28 HSV-1 x HSV-2 recombinants show the following: (i) Recombinants with heterogeneous L and S components or with heterogenous inverted repeats are viable. (ii) HSV-1 and HSV-2 genes appear to be functionally equivalent and with few exceptions co-lin... | 221,347 | [
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Enhanced efficiency of transfection of HSV DNA in HSV-1 DNA-transformed hamster cells. | The efficiency of transfection, i.e., the number of plaques per microgram of DNA, was compared for herpes simplex virus (HSV) type 1 and type 2, and herpesvirus eidolon (antigenically unrelated to HSV) DNAs in HSV DNA-transformed cells (EH/A44) and control hamster cells (EHT). The efficiency of transfection of HSV-1 an... | 221,357 | [
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Characterization of the replicative structures of the DNA of a herpesvirus (pseudorabies). | The replication of PRV DNA occurs in two phases, early and late. During the early stages of infection newly synthesized DNA is associated with molecules sedimenting with an S-value up to two-fold greater than that of mature viral DNA. These molecules represent unit-size linear or circular molecules, as well as small co... | 221,363 | [
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Characterization of human cytomegalovirus DNA: infectivity and molecular weight. | Human cytomegalovirus DNA was isolated from purified virions and further purified by sucrose density-gradient centrifugation. The viral DNA molecules were studied by electron microscopy and found to be linear and to have a length of 76.22 +/- 3.80 microM, corresponding to a molecular weight of 147.13 +/- 6.18 x 10(6). ... | 221,366 | [
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Inhibition of the multiplication of herpes simplex virus by aliphatic nitrosamines. | Non-toxic doses of dimethylnitrosamine and diethylnitrosamine inhibit the multiplication of herpes simplex virus type 1 and type 2 in HEp-2, Wi-38 and primary HEK cells. These results are somewhat unexpected, since both HEp-2 and Wi-38 cells lack detectable microsomal enzyme activity. The possible significance of the p... | 221,368 | [
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Induction of cellular DNA synthesis by defective human cytomegalovirus. | The results presented in this paper show that virus stocks enriched for defective particles are more effective in stimulating cellular DNA synthesis than are stocks relatively free of defective particles. Several lines of evidence support this conclusion: (1) Low levels of UV irradiation enhance the ability of standard... | 221,383 | [
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Suppression of in vitro Epstein-Barr virus infection: a new role for adult human T-lymphocytes. | In vitro EBV infection of lymphocytes from different sources indicated that B-cells of adult peripheral or fetal cord blood transform with equal efficiency whether assayed by DNA synthesis induction or immortalization. Unfractionated adult lymphocytes transformed much less efficiently than those from fetal cord blood. ... | 221,386 | [
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0.2151741,
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-0.2401751,
0.03824877,
0.1701375,
0.284159,
0.007021208,
0.01225884,
0.2446462,
0.2710158,
-0.3883194,
-0.26563,
-0.1999584,
-0.06858286,
-0.2764519,
0.260278,
0.1671319,
0.2378957,
-0.1111093,
-0.... |
Immune responses to vaginal or systemic infection of mice with herpes simplex virus type 2. | Relationships among cell-mediated immune (CMI) responses, neutralizing antibody, and macrophages in host resistance to vaginal or systemic infection with HSV-2 were defined in BALB/c mice. The importance of T-lymphocytes in resistance to either systemic or vaginal infection was demonstrated by increased susceptibility ... | 221,400 | [
-0.04109574,
-0.2083967,
-0.04198798,
-0.2349151,
0.2553874,
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0.1178255,
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0.09767964,
0.1725843,
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0.2689903,
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-0.2639977,
0.09085048,
-0.1954868,
0.288057,
0.0472707,
0.1268968,
0.0111995,
... |
Differences in susceptibility to herpes simplex virus infection of inbred strains of mice. | Marked differences were observed between the susceptibility of adult C57BL/6 and DBA/2 mice to infection with HSV-1. These differences were seen after various infection schedules but were most marked after i.p. infection. A significant difference between the LD50 after i.p. infection was also observed between LPS-resis... | 221,403 | [
0.07865565,
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0.1283342,
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0.08455861,
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0.3482437,
0.1738319,
0.002955999,
0.01940966,... |
Structure of the lipopolysaccharide from an Escherichia coli heptose-less mutant. I. Chemical degradations and identification of products. | The structure of lipopolysaccharide from a heptose-less mutant of Escherichia coli K-12 has been investigated. Lipopolysaccharide isolated from 32P-labeled cells was treated with mild alkali to yield two separable components: [OH-LPS]-I (approximately 70%) and [OH-LPS]-II (approximately 30%). Mild acidic treatment of [... | 221,486 | [
-0.1153459,
0.4044032,
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0.01508354,
0.004903101,
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0.1357032,
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0.1243734,
0.3333535,
0.08805124,
0.3944407,
0.2969954,
-0.1952908,
... |
Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin. | The brain contains two distinct molecular forms of the (Na,K)-ATPase (sodium and potassium ion-stimulated adenosine triphosphatase). They can be resolved by gel electrophoresis in sodium dodecyl sulfate, and can be identified by sodium-dependent, potassium-sensitive phosphorylation by [gamma-32P]ATP. They are present i... | 221,488 | [
-0.2419658,
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-0.06428608,
0.17504,
-0.03350814,
-0... |
Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3':5'-monophosphate-dependent protein kinase. | The sequences of two phosphopeptides isolated from the catalytic subunit of bovine cardiac muscle cAMP-dependent protein kinase (type II) and from two of its cyanogen bromide fragments, have been determined. One phosphorylation site is a threonyl residue located approximately 180 residues from the blocked NH2 terminus.... | 221,492 | [
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0.01961382,
0.06474761,
0.2992032,
0.3006971,
0.3135557,
-0.06229612,
... |
Total assignments, including four aromatic residues, and sequence confirmation of the decapeptide tyrocidine A using difference double resonance. Qualitative nuclear overhauser effect criteria for beta turn and antiparallel beta-pleated sheet conformations. | The complete assignments of all the proton magnetic resonance signals from each NH-CalphaH-CbetaH2 moiety in a complex peptide containing several residues of the same type has not yet been achieved without specific or stereospecific isotopic enrichment. We report the sequencing and proton magnetic resonance spectral as... | 221,496 | [
-0.1323506,
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0.04239012,
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0.4129962,
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0.02290189,
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0.2910218,
0.4063506,
0.2428205,
0.2046192,
0.07... |
In vitro and in vivo refractoriness to thyrotropin stimulation of iodine organification and thyroid hormone secretion. | Earlier studies indicated that initial exposure of thyroid slices to thyrotropin diminished responsiveness of the adenylate cyclase-cyclic AMP system, glucose oxidation, and (32)P(i) incorporation into phospholipids upon readdition of the hormone. The present studies demonstrate that slices from dog, beef, and human th... | 221,545 | [
-0.1269826,
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0.008203404,
0.3080807,
0.08036669,
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0.08378274,
0.1016688,
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-0.01467916,
0.05099043,
0.1909821,
0.1517802,
-0.1269... |
The stability constants of some metal ion complexes of 3',5'-cyclic AMP. | The stability constants of complexes of 3', 5'-cyclic AMP with Mg2+, Ca2+, Mn2+, Ni2+ and Co2+ were estimated at 30 degrees C in solutions of ionic strength about 0.15 containing about 130 mM K+ or tetramethylammonium ions. Values between 13 and 22 M-1 were obtained, indicating that only about 2% of cyclic AMP is prese... | 221,553 | [
-0.2488739,
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-0.3442786,
0.02368566,
0.02125959,
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0.09788977,
0.1171364,
0.1861909,
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-0.3644386,
0.1078475,
-0.2978246,
0.3339338,
0.3767675,
-0.1002624,
-0.006047658... |
The nature of covalent complexes of phosphoproteins with collagen in the bovine dentin matrix. | The bovine dentin matrix still contains some noncollagenous proteins after thorough extraction and decalcification. These have been obtained following digestion of the matrix by cyanogen bromide. Peptides containing non-collagenous portions were isolated by chromatography on diethylaminoethyl cellulose columns and frac... | 221,556 | [
-0.1921738,
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0.4783891,
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0.400186,
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0.01678685,
0.005652133,
0.05329049,
0.3378257,
0.3287491,
-0.08037196,
0.... |
Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus. | Endogenous retroviral gp70 was investigated as a participant in the pathogenesis of a lupus-like disease that spontaneously develops in four kinds of mice (NZB, NZB x W MRL/1, and male BXSB). Sera from these strains contain a heavy form of gp 70 that varies in sedimentation rates from 9S to 19S in sucrose density gradi... | 221,610 | [
0.06257689,
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0.1776322,
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0.3102036,
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0.285019,
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0.04495636,
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-0.1348865,
0.1348365,
0.1873605,
0.2089866,
0.1595583,
-0.171771,
... |
Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6. | Flow microfluorometry was used to assess levels of xenotropic murine leukemia virus envelope-related cell-surface antigens (XenCSA) expressed on lymphocytes of mice derived from crosses between C57BL/6 (B6) and DBA/2 (D2); 24 recombinant inbred strains (BXD RIs) and 62 backcross mice were studied. The results suggest t... | 221,612 | [
0.2700128,
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-0.2155517,
-0.03398848,
0.3577662,
0.001618737,
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0.1574876,
0.05149088,
-0.07684784,
0.03165568,
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-0.5063877,
-0.08582407,
0.03077682,
0.02649252,
0.2353183,
0.5694201,
0.09153198,
-0.184... |
Teaching interpersonal management for effective professional nursing practice. | The treatment environment is an important component of patient care. In order to provide more effective patient care one would want to be able to manipulate the environment, particularly the emotional environment. This is difficult to do and even more difficult to teach. The authors describe a teaching module in a bacc... | 221,653 | [
-0.1502402,
0.1347282,
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0.07225271,
0.06481794,
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0.01842945,
-0.2307031,
-0.2065652,
-0.07816965,
0.04335498,
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-0.3531606,
-0.6369376,
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0.0892948,
-0.343769,
0.2617487,
-0.1766762,
-0.003989351,
0.2385996,
0.2452928,
0.2212668,... |
Restriction endonuclease cleavage map of the DNA of JC virus. | A physical map of the sites cleaved by the following restriction endonucleases was derived for the DNA of JC virus, a human polyomavirus: EcoRI, HpaI, and PstI (one site each); HindII (four sites); and HindIII (three sites). By agarose gel electrophoresis of fragmented DNA, the size of full-length DNA of JC virus was e... | 221,677 | [
-0.2051922,
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0.01070682,
0.05717574,
0.3235075,
0.00782805,
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0.06023251,
0.07875784,
0.3712628,
0.2398371,
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0.1294399,
-0.3467218,
0.5353855,
0.3364586,
0.05323076,
0.2208052,
0.03392271,
-0.07547221,... |
Mapping and ordering of fragments of BK virus DNA produced by restriction endonucleases. | A total of 51 restriction sites were recognized within the BK virus genome by the combination of 10 different restriction endonucleases. These sites were mapped and oriented relative to one another as well as to the five fragments generated by the digestion of BK virus DNA with HindIII and EcoRI. The result was a compr... | 221,680 | [
-0.09481438,
0.02327716,
-0.02937798,
-0.07154872,
-0.005118949,
-0.08831216,
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0.05033471,
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0.345456,
0.1092229,
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0.06905235,
0.2386156,
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0.09622616,
-0.3229126,
0.2433312,
0.1940005,
0.00784304,
0.1572477,
0.02525889,
-0.0110... |
Concentration of myocardial cyclic AMP and ventricular fibrillation induced by aminophylline. | The concentration of myocardial cyclic AMP was measured in 9 dogs by radioimmunoassay after the administration of aminophylline. Fourteen dogs served as control. The concentration of cyclic AMP in the left ventricle was the highest and the lowest value was obtained in the right atrium in the control dogs. Ventricular f... | 221,701 | [
-0.578521,
0.01123761,
-0.5089666,
-0.5031527,
0.1434665,
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0.02281235,
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0.05974033,
0.3374318,
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0.08927932,
0.09214669,
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0.4400292,
-0.1031103,
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0.3175113,
-0.02315838,
-0.2004794,... |
Inhibitory effects of butylated hydroxyanisole on methylazoxymethanol acetate-induced neoplasia of the large intestine and on nicotinamide adenine dinucleotide-dependent alcohol dehydrogenase activity in mice. | Butylated hydroxyanisole (BHA), a widely used food additive, previously was found to inhibit various chemical carcinogens. In the present work, BHA, when added to the diet, inhibited the carcinogenic action of methylazoxymethanol (MAM) acetate on the large intestine of female CF1 mice. The effects of BHA on nicotinamid... | 221,717 | [
-0.4096869,
-0.1341901,
-0.1867398,
-0.1994497,
0.2373813,
-0.1237575,
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0.1032599,
0.1292403,
0.2866767,
0.09245128,
0.2245993,
0.3282419,
0.07354293,
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0.04840106,
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0.1158504,
0.06892556,
0.3142134,
-0.03051104,
-0.1482871,
-0.02908787,
... |
Effect of sera from hyperlipidemic subjects and high-density lipoproteinemic runners on the synthesis of DNA and glycosaminoglycans by cultured human aortic smooth muscle cells. | Effects of hyperlipidemic, normolipidemic and high-density-lipoproteinemic (HD lipoproteinemic) sera from active runners were studied on cultured human aortic smooth muscle cells. The synthesis of DNA, hyaluronic acid and sulphated glycosaminoglycans (GAGs) in the presence of the various sera was measured by the incorp... | 221,758 | [
-0.02458013,
0.01646863,
-0.3232884,
0.3402282,
0.207977,
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0.170952,
0.04652045,
0.02749556,
0.1021086,
0.003957334,
0.08701459,
0.01822396,
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-0.2426686,
-0.06099921,
-0.2320183,
0.2859587,
0.2613161,
0.1712129,
-0.2002458,
... |
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