title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Effects of opiate-like peptides, morphine, and naloxone in the photosensitive baboon, Papio papio. | The effects of intracerebroventricular (i.c.v.) or systemic injections of Met- or Leu-enkephalin, beta-endorphin, FK 33.824 (D-Ala2, MePhe4, Met(O5)-ol-enkephalin) and of morphine and naloxone have been studied in baboons, Papio papio, which spontaneously show photically induced epileptic responses. Animals were chroni... | 223,724 | [
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Blockade of progesterone-induced increase in hypothalamic luteinizing hormone-releasing hormone levels and serum gonadotropins by intrahypothalamic implantation of 6-hydroxydopamine. | The present study was undertaken to identify the hypothalamic locus where norepinephrine (NE) nerve terminals communicate with luteinizing hormone-releasing hormone (LH-RH)-containing neurons involved in the stimulatory feedback action of gonadal steroids on LH and FSH release. Ovariectomized rats received estradiol be... | 223,726 | [
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Effects of lanthanum on the heart sarcolemmal ATPase and calcium binding activities. | Effects of lanthanum on Ca2+-ATPase, Mg2+-ATPase, Na+-K+-ATPase, and calcium binding activities were studied in rat heart sarcolemma. Ten to 100 micrometers lanthanum depressed significantly the Ca2+-ATPase activity and 50--200 micrometers lanthanum inhibited the calcium binding activity. Lineweaver-Burk plots of the C... | 223,755 | [
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Effects of pancreatic polypeptide and vasoactive intestinal polypeptide on rat ileal and colonic water and electrolyte transport in vivo. | Two gastrointestinal peptides, vasoactive intestinal polypeptide (VIP) and pancreatic polypeptide, suspected of being associated with symptoms of WDHA syndrome (pancreatic cholera) were tested on the rat small and large intestine for their effects on water and electrolyte transport. Intravenous infusion of VIP (14.3 mi... | 223,821 | [
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alpha-Melanocyte-stimulating hormone and adrenocorticotropin in the regulation of glucocorticoid secretion during the perinatal period in sheep. | To determine the role of other ACTH-like peptides in the regulation of glucocorticoid secretion in fetal sheep, we examined the responses of the adrenal gland of fetal and newborn sheep to comparable single doses of alpha MSH (75 micrograms) or ACTH (50 micrograms) during the last third of gestation and the first month... | 223,827 | [
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Monolayer culture of animal cells with the gyrogen equipped with tubes. | The gyrogen with tubes has been the object of repeated trials carried out over a period of some years. The aim of these trials was essentially to multiply BHK cells in monolayer and to reproduce the FMD virus in one operation. At the laboratory stage, the gyrogen consisted of 3 rolling flasks; at the pilot stage, it eq... | 223,916 | [
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Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): an electron microscopic study. | A comparative ultrastructural analysis of malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma) revealed similar ultrastructural features in this group of tumors. However, by electron microscopy these tumors can be differentiated on the basis of cytopla... | 223,963 | [
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Evidence for the role of superoxide radicals in neutrophil-mediated cytotoxicity. | Human peripheral neutrophils became cytotoxic to chicken red blood cells (CRBC) in the presence of lectins as assessed by release of 51chromium from labelled target cells. Phytohaemagglutinin (PHA) and concanavalin A (Con A), which caused time-dependent and dose-dependent cytotoxicity over a concentration range of 25--... | 223,976 | [
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Studies on the mechanism of macrophage aggregation induced by lymphokines. | Macrophage aggregation (measured by a light-scattering technique) induced by unpurified lymphokine preparations has been investigated. This has been shown to be Ca2+ or Mg2+ dependent and to be inhibited by a number of agents known to affect cellular physiology and biochemistry. The divalent cation ionophore A23187 cau... | 223,977 | [
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"Triple infections" (fungal, bacterial and viral) in immunosuppressed renal transplant recipients. | In a period of 5 years, 8 out of 77 renal transplant patients showed simultaneous fungal, bacterial and viral infections. Candida albicans was found in all cases. The most severe bacterial complications were infections with Klebsiella, Pseudomonas and Staphylococcus aureus. Cytomegalovirus, persistent HBsAg positive he... | 224,003 | [
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Reduced lung volume during behavioral active sleep in the newborn. | In a previous study of newborn infants we observed overall rib cage collapse during active sleep and postulated that the lungs also could be deflated, leading to reduced oxygen stores and circumstances favoring the rapid development of hypoxemia during apnea. In this study, thoracic gas volume (TGV) has been measured d... | 224,015 | [
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Effects of high oxygen exposure on bioenergetics in isolated type II pneumocytes. | O2-mediated alterations in cell energy metabolism may play a role in structural and functional abnormalities described in type II pneumocytes (T-II-P) following in vivo hyperoxia. Bioenergetic alterations produced by hyperoxia (95% O2) were therefore examined in a culture-maintained cell line derived from T-II-P. Expos... | 224,021 | [
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Observations on the mechanism of the reversible epimerization of GDP-D-mannose to GDP-L-galactose by an enzyme from Chlorella pyrenoidosa. | An enzyme fraction from the green alga Chlorella pyrenoidosa that catalyzes the reversible epimerization of guanosine 5'-diphosphate D-mannose to guanosine 5'-diphosphate L-galactose brings about the incorporation of tritium from tritium-labeled water into the hexosyl moieties of those sugar nucleotides. The hexoses w... | 224,034 | [
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Biosynthesis of the Ca2+- and Mg2+-dependent adenosine triphosphatase of sarcoplasmic reticulum in cell cultures of embryonic chick heart. | The biosynthesis of the Ca2+- and Mg2+-dependent adenosine triphosphatase of sarcoplasmic reticulum was studied in cell cultures of embryonic chick heart. Rates of synthesis were estimated from the incorporation of tritium-labeled leucine into the ATPase. Newly synthesized ATPase was isolated from cells by immunoprecip... | 224,035 | [
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Contribution of cyclic adenosine 3':5'-monophosphate to the regulation of bacterial glycogen synthesis in vivo. Effect of carbon source and cyclic adenosine 3':5'-monophosphate on the quantitative relationship between the rate of glycogen synthesis and the cellular concentrations of glucose 6-phosphate and fructose 1,6... | When either fructose, glycerol, or succinate served as a sole source of carbon and energy in nitrogen-starved cultures of Escherichia coli W4597(K) the values of the kinetic constants of the equation that expresses the relationship between glycogen synthesis and hexose phosphates were different from the values observed... | 224,050 | [
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Pitfalls to avoid: accidental intravenous injection of Ethiodol. | Direct intravenous injection of Ethiodol occurred at lymphography. Early fluoroscopic or radiographic film evaluation, and careful monitoring of injection rates, would help to avoid this complication. | 224,063 | [
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An attenuated form of congenital virilizing adrenal hyperplasia. | The families of two patients with hirsutism and oligomenorrhea were studied with iv ACTH (Cortrosyn) stimulation. The parents responded with a combined incremental rise of progesterone and 17-hydroxyprogesterone greater than 6.5 ng/dl.min, a response seen in the heterozygote parents of patients with congenital virilizi... | 224,072 | [
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Angiofibromas in tuberous sclerosis: a light and electron microscopic study. | Angiofibromas from two patients with tuberous sclerosis were studied by light and electron microscopy. Light microscopy revealed that these tumor-like nodules (which in the past have been called adenoma sebaceum) were made up of dilated capillaries, venules and arterioles embedded in connective tissue. At the ultrastru... | 224,082 | [
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Hemodialysis hypotension is not the result of uremic peripheral autonomic neuropathy. | Five chronic hemodialysis patients with persistent hypotension during dialysis (MAP: 74.2 +/- 3.1 mm Hg) were given a number of standard tests of autonomic nervous system function and compared with eight normotensive hemodialysis patients (MAP: 96.4 +/- 3.4 mm Hg). Tests of efferent sympathetic nerves were normal in bo... | 224,121 | [
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Virology studies and Bell's palsy. | A retrospective analysis of 104 cases of facial nerve paralysis is presented, attention being focused on possible clues to link Bell's palsy with a virus infection. The findings are compared to those of another larger prospective series of cases. Some recent developments which suggest that Bell's palsy represents a rea... | 224,123 | [
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Extrapulmonary manifestations of adenovirus type 7 pneumonia simulating Reye syndrome and the possible role of an adenovirus toxin. | Three children developed extensive extrapulmonary disease in the course of fatal adenovirus type 7 pneumonia. Several clinical features, including the unexpected onset of coma, suggested the development of Reye syndrome, but biochemical and histopathologic findings were inconsistent with this diagnosis. Virologic and p... | 224,159 | [
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Dorsal root potentials and changes in extracellular potassium in the spinal cord of the frog. | 1. In the present study changes in extracellular potassium, ([K]e), were recorded in the isolated spinal cord of the frog with glial cell recordings and K-selective micro-electrodes to test the hypothesis that elevations in [K]e during neuronal activity produce the dorsal root potential (d.r.p.). 2. Sucrose gap recordi... | 224,169 | [
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Presynaptic action of curare. | 1. As a result of a conditioning phrenic nerve stimulus, end-plate currents (e.p.c.s) in a voltage clamped uncurarized cut diaphragm show a facilitation which reaches its maximum at 30-40 msec and subsequently decays with a time constant from 150 to 200 msec. In curarized (cut or uncut) diaphragms, however, the conditi... | 224,174 | [
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Adenosine 3'5'-monophosphate phosphodiesterase of buffalo spermatozoa. | The cyclic AMP-phosphodiesterase (EC 3.1.4.17) of buffalo spermatozoa is distributed in the head, mid-piece and tail fractions and has multiple forms, 70% of which is in the bound form. The bound enzyme was not solubilized by Triton X-100, lubrol or hyamine 2389. Kinetic measurements of the soluble enzyme showed two ap... | 224,188 | [
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Role of oral contraceptive agents in the pathogenesis of liver tumors. | Since the introduction of oral contraceptive steroids in 1960 there has been a sharp increase in the incidence of benign liver tumors. Epidemiologic and other evidence links focal nodular hyperplasia and hepatic cell adenoma to the use of these agents. The risk increases with long-term exposure. The majority of patient... | 224,197 | [
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Pathology of primary liver cancer. | After a brief survey of the factors that play a role in the etiopathogenesis of human hepatocellular carcinomas, a detailed description is given of the macroscopic and microscopic features of human liver cancers as well as their association with cirrhosis. The ultrastructural features of liver cancers of various degree... | 224,201 | [
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[Defective organification of iodine in an infant demonstrated with 123J and gamma camera (author's transl)]. | A defective organification of iodine is demonstrated in a two year old male infant. The availability and a relatively simple radiation detector and storage system (gamma camera and 1600 word memory) gives a reasonable low radiation dose, allows correction for extrathyroid neck activity and obviates problems of collimat... | 224,292 | [
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[Investigations concerning the hypothalamic-hypophysial regulation of aldosterone secretion (author's transl)]. | In 17 patients with retrospectively healthy adrenals we performed a LHRH-test, a TRF-test and an ACTH-test in the short modification. Additionally we determined plasma aldosterone and renine levels. Concerning the LHRH-tests and the TRF-tests we did not find any differences on the aldosterone values. Concerning the ACT... | 224,294 | [
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Normal and pseudorabies virus infected primary nerve cell cultures in scanning electron microscopy. | Primary cell cultures from the central nervous system of the embryonic rat were inoculated with pseudorabies virus. Their morphological changes were studied by phase contrast microscopy and by scanning as well as by transmission electron microscopy. Uninfected cultures display two distinct cell layers in scanning elect... | 224,296 | [
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[Covalent bond between RNA and protein in encephalomyocarditis virus]. | Deproteinized encephalomyocarditis [32P]RNA, after digestion with a mixture of RNases A, T1 and T2, yields mononucleotides and a labelled compound, which is positively charged at pH 3.5. This product can be digested with pronase and has a close electrophoretic mobility to a protein with a molecular weight of 7000-8000.... | 224,308 | [
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... |
[Display of a monosynaptic excitatory connection in the structure of a crosscorrelation histogram]. | Reflection of the monosynaptic excitatory connection in the cross correlation histogram structure was investigated using mathematical model of neuron interactions. The peculiar features of crosscorrelation histogram primary peak waveform and situation permitting distinguishing the monosynaptic excitatory connection fro... | 224,328 | [
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Role of adrenergic structures in functional control over the cerebral circulation. | An investigation of the cerebral circulation by the thermoelectric method showed that stimulation of the cervical sympathetic nerve leads to considerable changes in the blood supply to the brain. The changes in blood flow are biphasic in character: An initial small increase is followed by a decrease below the original ... | 224,339 | [
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[The role of fiberoptic bronchoscopy in the diagnosis of pulmonary cancer]. | Cancer of the lung is becoming increasingly common. In the U.S., it has the highest mortality of the neoplastic diseases, well ahead of cancer of the colon and rectum. Surgical and/or complementary management is poorly effective because it comes too late. Early diagnosis and treatment are essential, therefore. Preclini... | 224,348 | [
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Genital Chlamydia trachomatis infections in patients with cervical atypia. | Of 177 gynecologic outpatients with cervical dysplasia studied, 29 (16%) were found to excrete Chlamydia trachomatis from their urogenital tract. Sera collected from 93 of these patients were significantly more often positive for and showed higher levels of antichlamydial micro-complement fixation (CF) and immunofluore... | 224,353 | [
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Accumulation of 125I in the oocytes, thyroids, and plasma of laying Japanese quail treated with cyclic AMP, theophylline, or prostaglandins E1 or E2. | Dibutyryl cyclic AMP, theophyline, or prostaglandins E1 or E2 were injected intraperitoneally into laying Japanese quail in an attempt to stimulate increased transference of iodide by the ovarian membranes. Theophyline induced increased 18-hr 125I accumulations (by 7 to 18% of the injected dose) of borderline significa... | 224,386 | [
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0... |
[Histology of cerebellar metastasis of bronchial oat cell carcinoma]. | Anatomo-pathological examination of 28 bronchic oat-cell carcinoma, all with cerebellar metastases and which are very often cerebral. In half of the cases, these localized cerebellar metastases contain palisades. These formations which haven't been described until now within intracranial metastases, can't be considered... | 224,451 | [
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[Extra intestinal manifestations of Crohn's disease (author's transl)]. | The extra intestinal manifestations of Crohn's disease (CD) are not devoid of interest. They can, by themselves, aggravate the CD. Some of them have to be searched systematically (urinary complications, spondylarthritis and sacro-iliac arthritis). Amongst our 60 cases of Crohn's disease of the colon or of the ileon and... | 224,470 | [
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[Surgical treatment of Crohn disease of the colon. (38 cases) (author's transl)]. | From 1959 to december 1972 thirty-eight patients out of sixty having Crohn disease of the colon alone or with ileal and/or rectal involvement were operated upon. We had four post-operative deaths and one a long time after the intervention, but in relation with the initial Crohn disease. These thirty-eight patients had ... | 224,474 | [
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[Menetrier's disease and edematous syndrome (author's transl)]. | The authors report a case of Menetrier's disease revealed in a 51 years woman before oedomas by systematic gastroscopy. Somes particularities of this case authorize to argue problems put by this disease: a thyroid nodule treated by L + triodothyronin; an eosinophilia; a biological study of gastric secretion, gastrin an... | 224,485 | [
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[Human cysticercosis. Four cases. (second part) (author's transl)]. | Beside the principal aspects of cysticercosis (see the first part of this article) there are others clinical forms : medullar, ocular, subcutaneous, often associated to cerebral cysticercosis, latent or not. The complemental investigations are numerous, their value is variable. The complemental investigations are numer... | 224,491 | [
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... |
[Sudden death in new-born babies (author's transl)]. | This sudden death of a new-born baby, which had been thriving up to then, is a dramatic but not exceptional event. A systematic search for the etiology must be made, and this should include an autopsy in order that the diagnosis of "sudden and unexplained death" is confirmed only after eliminating all other possible ca... | 224,505 | [
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Double tumours of the liver following intravenous thorotrast injection. Patho-anatomical report on two cases. | Observations on the contrast between the livers of two patients who underwent an arteriogram with thorotrast in 1941 have been made. The first case produced a cholangicellular carcinoma (CCC) in addition to atypical proliferations of sinusoidal lining cells. The second case produced a very rare tumour combination of a ... | 224,567 | [
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Nonchromaffin paraganglioma of the duodenum. | A benign nonchromaffin paraganglioma of the duodenum is described and compared with other reported cases. Duodenal location is extremely rare but the morphology, based on the optical microscopic pattern (Zellballen) and the ultrastructural appearance is, comparable with paragangliomas of other sites. The lack of nerve ... | 224,570 | [
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[Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis]. | Activities of hexokinase, glucokinase, cytochrome oxidase as well as amount of mitochondrial protein and subcellular distribution of hexokinase were studied in rat liver tissue after administration of acetyl aminofluorene and diethyl nitrosamine. Activity of the enzymes was altered in the same direction both in the pri... | 224,600 | [
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Fingerprint inclusions and circular structures in the muscle. Report of a case. | Fingerprint inclusions, circular structures of unknown origin, mitochondrial changes, dilatation of the sarcoplasmic reticulum, rods of Z-line material, elongated T-systems, honeycombs, and myelin figures were present in some damaged muscle fibres. Many damaged fibres showed loss of myofilaments and groups of atrophied... | 224,637 | [
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The prognosis in congenital lower limb hypertrophy. | Twenty-eight patients with congenital total hypertrophy and ten patients with lower limb hypertrophy with congenital vascular abnormalities are reviewed. The pattern of increase in leg length discrepancy during growth and its influence on surgical management is discussed and the clinical features of the affected limbs ... | 224,640 | [
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Primary carcinoma of the liver. A histological study of 52 cases from Denmark. | Among 7763 autopsies performed in Greater Copenhagen in 1973, there were 309 cases of cirrhosis of the liver and 52 cases of primary carcinoma of the liver (PCL). Of the latter, 45 were hepatocellular carcinoma (HCC), 4 combined HCC and cholangiocarcinoma (CCC) and 3 CCC. HCC was found in 7.8 per cent of the cirrhotic ... | 224,641 | [
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Effects of macrophages in resistance to murine cytomegalovirus infection. | In a preliminary experiment, the protective effects of peritoneal macrophages was shown by transferring macrophages from adult mice to newborn and to 7 and 14 days old mice. It was demonstrated that such transplantation protect suckling mice from intraperitoneal infection with MCMV by reducing the mortality rate from 1... | 224,649 | [
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Demonstration of EBNA (Epstein-Barr virus nuclear antigen) antibodies of different immunoglobulin classes. | Anit-EBNA IgM, a previously unknown antibody, was detected by the antihuman globulin anticomplement immunofluorescence (ACIF) method in serum samples from acute infectious mononucleosis (IM) of Epstein-Barr virus (EBV) origin. The antibody disappears from the serum in some weeks during convalescence. It was absent in a... | 224,651 | [
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Effect of fasting on tubular phosphorus reabsorption. | In the thyroparathyroidectomized (TPTX) rat, fasting increased urinary phosphorus excretion by decreasing the tubular reabsorption of P1 (TRP) and resulted in hypophosphatemia. The administration of either sucrose or NaHCO3 prevented the metabolic acidosis associated with fasting and decreased the phosphaturia, indicat... | 224,713 | [
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Lipoprotein particles in the jejunal mucosa of postnatal developing rats. | The jejunal mucosa of neonatal rats contains lipid particles of the same size, electron density and intracellular and extracellular distribution as particles identified by others in adult jejunum as lipoprotein particles. As in fetal jejunum obtained during the last three days of gestation, the jejunal mucosa of unsuck... | 224,733 | [
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Phosphodiesters in muscular dystrophies. | Phosphorus nuclear magnetic resonance studies of various normal and dystrophic muscles have demonstrated differences in phosphodiester contents. Dystrophic chicken pectoralis muscle contains elevated levels of the diester SEP, and Duchenne dystrophic human leg muscle lacks the diester GPC. It is shown that SEP may be c... | 224,750 | [
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Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro. | The antiviral effect of the nucleoside analog 5-iodo-5'-amino-2',5'-dideoxyuridine (AIU) was tested with three isolates of varicella-zoster virus (VZV). AIU concentrations of 10 to 800 muM (3.5 to 288 mug/ml) reduced the number of plaques produced by VZV-infected cells and cell-free VZV from approximately 30 to 95%. Sm... | 224,809 | [
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Extragonadal germ-cell tumours. | The case histories of two patients with an extragonadal germ-cell tumour are discussed. One had a retroperitoneal embryonal carcinoma, and the other had a mediastinal choriocarcinoma-seminoma. The pathogenesis, symptomatology, diagnosis and treatment of these rare tumours are discussed in some detail.? | 224,823 | [
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... |
Recurrent attack of rotavirus gastroenteritis after adenovirus-induced diarrhoea. | A 14-month-old baby boy suffered a second attack of rotavirus gastroenteritis within one month of the initial one. The second attack followed a diarrhoeal episode associated with adenovirus. Gastrointestinal symptoms in the second attack were more severe than those of the first. The adenovirus-associated enteritis was ... | 224,825 | [
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0.1543891,
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0.05133611,
0.104148,
0.1738862,
-0.0730665,... |
[Swine cell sublines with different ploidies. III. Susceptibility to foot-and-mouth disease virus]. | IB-RS-10-II subline with tetraploid level cells was more susceptible to the infection by the foot-and-mouth disease virus (FMDV) ASQ-PG strain than IB-RS-10-I subline with diploid level cells, when number and size of plaques and cytopathogenic effect of the virus were used as criteria. Besides, the virus yield in one-c... | 224,843 | [
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Effect of fluocortin butylester and beclomethasone dipropionate on the adrenal gland in beagle dogs. | The effect of butyl-6 alpha-fluoro-11 beta-hydroxy-16 alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (fluocortin butylester, Vaspit) administered intratracheally and of beclomethasone dipropionate given intratracheally or orally on the adrenal glands of beagle dogs was investigated. The adrenal function was evaluated u... | 224,887 | [
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Synaptic membrane proteins as substrates for cyclic AMP-stimulated protein phosphorylation in various regions of rat brain. | Synaptosomal plasma membranes from mammalian brain contain protein kinase activity which phosphorylates endogenous membrane proteins and is stimulated by cyclic AMP. Using polyacrylamide gel electrophoresis it was shown that at least ten proteins in the synaptosomal plasma membrane fraction could be phosphorylated by e... | 224,925 | [
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Smooth muscle cell sarcolemma. Purification and properties of plasma membranes from the rat uterus. | A membrane fraction with sarcolemmal properties was purified from the smooth muscle layers (myometrium) of rat uterus by successive differential and equilibrium centrifugation in sucrose. The putative sarcolemmal fraction was identified by iodination with [125I]iodosulfanilic acid, had an equilibrium density of 1.15, a... | 224,928 | [
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Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. | A detailed comparison of the interaction of beta-adrenergic receptors with adenylate cyclase stimulation and modification of this interaction by guanine nucleotides has been made in two model systems, the frog and turkey erythrocyte. Objective analysis of the data was facilitated by the development of new graphical met... | 224,939 | [
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Role of cyclic AMP and related enzymes in rat lung growth and development. | Cyclic AMP levels in rat lungs showed phasic elevations which peaked during fetal, neonatal and late postnatal periods of development. Lung phospholipids showed major alterations in their levels during fetal and early neonatal life. Alterations in glycogen levels were accompanied by parallel changes in phosphorylase a/... | 224,944 | [
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Abnormal red cell membrane phosphatase activity in an unidentified congenital hemolytic anemia. | The erythrocyte membrane contains a neutral phosphatase, which was studied with p-nitrophenyl-phosphate as the substrate. The enzyme was investigated in four members of the same family, suffering from a congenital spherocytic hemolytic anemia. Although the condition was transmitted as a dominant trait, it was not ident... | 224,968 | [
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Behavioral and biochemical analysis of GABA-mediated inhibition in the early chick embryo. | Exogenous gamma-aminobutyric acid (GABA) decreased spontaneous motility in 4-, 6-, 7-, 9-, and 13-day chick embryos; the younger embryos were more sensitive. Neither the positional isomers of GABA, alpha-aminobutyric acid (AABA) and beta-aminobutyric acid, nor the principle GABA catabolite, succinic acid, decreased mot... | 224,974 | [
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An approach to measuring the in vivo transformation of glycerol to a very low density lipoprotein triglyceride. | This paper describes a new method which permits measurement of the steady-state rate of transformation of serum glycerol to a very low density lipoprotein (VLDL) triglyceride in vivo in dogs. Although the turnover of glycerol and the turnover of VLDL triglyceride glycerol have both been previously measured, the rate of... | 224,984 | [
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Relationship between survival and histologic type in small cell anaplastic carcinoma of the lung. | Survival and histologic subtype were compared in 61 patients with small cell anaplastic lung cancer. Patients with lymphocyte-like (oat cell) and fusiform histologies treated with chemotherapy had longer median survivals than the polygonal and other varieties on the same treatment. Likewise, when detectable disease was... | 225,003 | [
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An infectivity assay for bovine leukemia virus using the immunoperoxidase technique. | This report describes the development of a 7-day infectivity assay for bovine leukemia virus (BLV) which is based on the induction of the major internal virion antigen (a protein with a molecular weight of 25,000) in susceptible indicator monolayer cell cultures. In this assay, the antigen is detected in the indicator ... | 225,012 | [
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... |
Ornithine decarboxylase activity, cell proliferation, and tumor promotion in mouse epidermis in vivo. | The effect of different phorbol esters and of mechanical treatment on the activity of ornithine decarboxylase in mouse epidermis in vivo was investigated. The strong promoter 12-O-tetradecanoylphorbol-13-acetate as well as the weak promoters phorbol dibenzoate and the 12-O-tetradecanoylphorbol-13-acetate analog 12-O-te... | 225,017 | [
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The distribution of endogenous chicken retrovirus sequences in the DNA of galliform birds does not coincide with avian phylogenetic relationships. | The chicken is a domesticated form of Red Jungle-fowl (Gallus gallus), which belongs to the Pheasant family (Phasianidae) within the order Galliformes. Domestic chickens carry the genome of the endogenous retrovirus RAV-O as DNA sequences integrated into host chromosomes transmitted through the germ line. We have exami... | 225,036 | [
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Loss of integrated viral DNA sequences in polyomatransformed cells is associated with an active viral A function. | Rat cells transformed by polyoma virus contain, in addition to integrated viral DNA, a small number of nonintegrated viral DNA molecules. The free viral DNA originates from the integrated form through a spontaneous induction of viral DNA replication in a minority of the cell population. Its presence is under the contro... | 225,038 | [
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The structure of the termini of the DNA of Epstein-Barr virus. | We have studied the DNA of Epstein-Barr virus (EBV) isolated from the B95-8 strain of that virus (Miller and Lipman, 1973). When EBV DNA is partially digested with lambda-exonuclease and allowed to reanneal, up to 50% of the full-length molecules circularize. The arrangements of nucleotide sequences containing the term... | 225,039 | [
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Structure of the 3' hairpin termini of four rodent parvovirus genomes: nucleotide sequence homology at origins of DNA replication. | The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence hete... | 225,040 | [
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Comparison of two micromethods for determination of lipoprotein cholesterol in plasma. | We compared the results obtained by a micromethod for the determination of plasma lipoprotein cholesterol, in which electrophoresis is used to separate the lipoprotein fractions (beta-, pre-beta-, and alpha-lipoproteins), with those determinations with ultracentrifugation (low-density, very-low-density, and high-densit... | 225,060 | [
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Apoenzyme of aspartate aminotransferase isozymes in serum and its diagnostic usefullness for hepatic diseases. | Aspartate aminotransferase in the sera of normal subjects and of patients with hepatic diseases has been immunologically separated into two isoenzymes, cytosolic aspartate aminotransferase and mitochondrial aspartate aminotransferase. The activity of the isoenzymes was measured in three different buffer solutions with ... | 225,064 | [
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Peroneal nerve paralysis: a complication of extensor reconstruction of the knee. | Adequate hemostasis is extremely important in extensor reconstruction of the knee and possibly all knee injury. Hemarthrosis postoperatively contributes to postoperative discomfort and may increase the risk of infection. Hematoma formation is also responsible for neurovascular complications. Peroneal nerve palsies were... | 225,073 | [
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Reliability of Doppler sonography in extracranial cerebro-vascular stenosis. | Of our patients who underwent quantitative Doppler sonography (Haemato-Tacho-Graphy), 382 underwent carotid angiography and 61 vertebral artery angiography. The reliability of the method proved to be between 90 and 95 percent for carotid as well as for vertebral arteries. The HTG proved to be a useful addition to angio... | 225,076 | [
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Lacrimal sweating in a patient with Reader's syndrome. | A patient is described with a right-sided Reader's syndrome and extensive sweating in the frontal area above the right eye. This pathological sweating can be explained by sprouting of lacrimal parasympathetic fibres in the previous denervated sympathetic sudomotor pathways to that area. | 225,078 | [
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Hepatic binding sites for angiotensen II in the rat. | 1. 125I-labelled (Asn1,Val5)-angiotensin II (125I-labelled AII) incubated with purified rat liver membranes was degraded with time, as estimated by three techniques: binding to an excess of specific antibody, polyacrylamide-gel electrophoresis and rebinding to fresh membranes. Degradation was inhibited in the presence ... | 225,088 | [
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9-(2-hydroxyethoxymethyl)guanine as an inhibitor of herpes simplex virus replication. | The drug 9-(2-hydroxyethoxymethyl)guanine effectively inhibits herpes simplex virus replication. It is selectively phosphorylated by the virus-induced thymidine kinase but not by normal cellular thymidine kinase. | 225,135 | [
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[New aspects in the concept of adjuvant and after-care therapy for gastric carcinoma?]. | Basis and current possibilities of adjuvant therapy in gastric cancer are discussed. The response rate with 5-FU und nitrosoureas for advanced gastric cancer is significantly superior to all other regimens. Based on Japanese experiences a higher survival rate is observed in the curatively resected patients treated with... | 225,137 | [
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[Electroencephalographic assessment of dosage and sleep-profile in a hypnotic Triazolothienodiazepine (author's transl)]. | We 941, a Triazolodiazepine, has satisfying hypnotic properties. The optimum dosage lies nearly at 0.3 mg. In this dosage the sleep-begin is shortened, the number of nightly wakeness is decreased and the total sleep-time is extended, while the sleep-profile remains unchanged. A normal cycling can be taken as a sign of ... | 225,156 | [
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Effects of ACTH and calcium on cyclic AMP production and steroid output by the zona glomerulosa of the adrenal cortex. | Effects of ACTH and calcium on cyclic AMP production and steroid output by the zona glomerulosa (the capsular fraction) from the rat adrenal cortex have been studied. Although high concentrations of extracellular calcium potentiated the stimulatory action of ACTH on cyclic AMP and aldosterone output, tetracaine or vera... | 225,162 | [
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Effect of chronic ethanol treatment on specific [3H]ouabain binding to (Na+ + K+)-ATPase in different areas of cat brain. | Chronic ethanol administration to cats increased specific [3H]ouabain binding by 63% in cerebral cortex, 47% in cerebellum, 84% in amygdala, and 100% in hippocampus when the binding assays were performed in the presence of 160 nM [3H]ouabain. There was no significant change in specific [3H]ouabain binding in hypothalam... | 225,178 | [
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0.0... |
Inhibition of fundic strips from guinea-pig stomach: the effect of theophylline on the membrane potential, muscle contraction and ion fluxes. | The effect of theophylline on the smooth muscle cells of the fundic part of the stomach of the guinea pig was investigated. Theophylline hyperpolarized the membrane, inhibited spike discharges and slow waves and produced relaxation of the muscle cells. Furthermore, the theophylline-induced relaxation was not affected i... | 225,182 | [
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0.09459521,
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[Seromonitoring of laboratory mouse and rat colonies for common murine pathogens (author's transl)]. | During a period from 1973 to 1978, 392 and 225 lots including 12,232 mouse and 8,044 rat individual sera, respectively, were examined for antibodies to murine hepatitis virus, Sendai virus, Bordetella bronchiseptica, Mycoplasma pulmonis, Tyzzer agents, Salmonella typhimurium and Corynebacterium kutscheri. Of mouse lots... | 225,183 | [
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... |
[Homoanalogues of pyrimidine nucleosides. XII. 3,6-anhydro-1,2-bis-desoxy-1-(pyrimidin- and 5-halopyrimidin-1-yl)-D-arabinohexitols; 3,6-anhydro-1-desoxy-1(5-halopyrimidin-1-yl)-D-glucitols]. | Lithium aluminium hydride reduction of 3,6-anhydro-1-o-benzoyl-4,5-o-isopropylidene-2-o-p-tolylsulfonyl-D-mannitol (II) gives with 74% yield 3,6-anhydro-2-deoxy-4,5-o-isopropylidene-D-arabino-hexitol (III). This compound is used as its corresponding 1-o-p-toluene-sulfonate (IV) for the N-1 alkylation of uracil, 5-fluor... | 225,200 | [
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0.3787546,
0.5430868,
0.1234512,
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0.088... |
[Mechanisms of spontaneous hypoglycaemia in the adult (author's transl)]. | Hypoglycaemia increases hepatic glucose output; insulin release is suppressed and the secretion of counter regulatory hormones enhanced. Catecholamines and glucagon seem to play a major role. The brain energy content is initially preserved, but the neuronal activity exhibits a 40-60 % decrease. Neither cerebral blood f... | 225,219 | [
0.07911714,
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0.1515762,
0.1386652,
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Unique characteristics of superoxide production by human eosinophils in eosinophilic states. | Eosinophils from patients with peripheral blood eosinophilia and human neutrophils from normal subjects and patients with neutrophilia produced superoxide anion (O2-) in vitro at similar rates in the absence of stimulation and exhibited comparably increased rates of O2- production during the initial 1 h of incubation w... | 225,266 | [
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0.02766473,
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... |
Vascular basophilia in ocular and orbital tumors. | The occurrence of vascular basophilia in ocular tumors has been a selective histologic feature of retinoblastomas. We recently observed a metastatic oat-cell carcinoma to the choroid which also demonstrated such a vascular hematoxyphilia. Histologic review of a variety of ocular and orbital metastatic carcinomas failed... | 225,286 | [
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0.3799613,
0.5757806,
0.0624404,
0.3861817,
0.165908,
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Adenovirus types 8 and 19 infection of rabbit corneal organ cultures. | Adenovirus types 8 and 19 are responsible for a large number of cases of acute follicular conjunctivitis, mainly in the form of epidemic keratoconjunctivitis (EKC). This study successfully demonstrates the establishment of adenovirus infection in rabbit corneal organ cultures. Normal rabbit corneas were maintained in c... | 225,288 | [
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0.06050406,
-0.00... |
Application of direct cannulation and injection lymphangiography to the study of the canine cardiac and pulmonary efferent mediastinal lymphatics. | Lymphangiograms of canine cardiac and pulmonary efferent mediastinal lymphatics were made by cannulation and injection of Ethiodol. Injections were made singly and serially. The mediastinal lymphatics and lymph nodes, which constitute the pathways of drainage of the heart and lungs, were delineated from the point of ca... | 225,290 | [
-0.03613877,
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0.185579,
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0.1145504,
0.1813733,
0.04470189,
0.06580402,
0... |
Overview of selected basic research in autism. | Basic research in autism is reviewed. There is mounting indication, but as yet inconclusive evidence, of unique physiologic disturbances etiologically related to autism. Additionally there is indication that some of the physiologic disturbances found in autistic children are also present in children with other developm... | 225,298 | [
-0.217946,
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0.08530979,
0.07394564,
0.09324814,
0.04390343,
-0.03492567,
-0.2194294... |
Nicotinamide adenine dinucleotide metabolism in Candida albicans. | The functional pathways of nicotinamide adenine dinucleotide (NAD) biosynthesis and their regulation were studied in the dimorphic fungus Candida albicans. The presence of a functional endogenous pathway of NAD biosynthesis from tryptophan was demonstrated. In addition, nicotinamide served as an efficient salvage precu... | 225,302 | [
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0.3102168,
0.2766297,
-0.1779628,... |
Regulation of phosphoglycerate phosphomutase in developing forespores and dormant and germinated spores of Bacillus megaterium by the level of free manganous ions. | The large depot of phosphoglyceric acid (PGA) which is accumulated within spores of Bacillus megaterium is greater than 99% 3-phosphoglyceric acid (3-PGA). The 3-PGA depot is stable in forespores and dormant spores, but is utilized rapidly during spore germination. When spores were germinated in KBr plus NaF, the PGA d... | 225,303 | [
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0.3221875,
0.6183698,
0.1974319,
0.06269376,
... |
The use of soybean trypsin inhibitors as phosphorylatable substrates for a rat liver protein kinase. | Phosphorylation by a cAMP-independent rat liver protein kinase of protein substrates containing the structural feature required by mammary gland casein kinase (-Ser-X-Glu/Asp) has been demonstrated. In particular, the Bowman-Birk Soybean trypsin inhibitor, which is characterized, like other legume protease inhibitors, ... | 225,305 | [
-0.0005544484,
0.2103755,
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0.124712,
0.3783832,
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0.0217476,
0.1598353,
0.3211333,
-0.07236521,
... |
Characterization of lipotropin-, corticotropin-, and beta-endorphin-immunoreactive materials secreted in vitro by a human pituitary adenoma responsible for a case of Nelson's syndrome. | A human pituitary adenoma responsible for a case of Nelson's syndrome was maintained in organ culture and the incubation medium was examined with four different RIAs; human corticotropin (ACTH), beta-MSH, lipotropin (LPH), and beta-endorphin (beta-End). All four immunoreactivites (IRs) were present in the medium obtain... | 225,344 | [
-0.3437467,
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0.1317647,
0.4103262,
0.1388302,
0.1031617,
-0... |
Maternal stress and pituitary-adrenal manipulations during pregnancy in rats: effects on morphology and sexual behavior of male offspring. | The purpose of the present study was to determine whether the demasculinizing and feminizing effects of prenatal stress (i.e., stress applied to the mother during pregnancy) in rats reported previously are mediated by activation of the maternal pituitary-adrenal axis. Neither whole-body restraint, with or without hyper... | 225,355 | [
-0.06614769,
0.3410725,
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0.02179669,
-0.05734035,
0.1414174,
0.2326538,
-0.02061913,
-0.0594... |
Cell-free varicella-zoster virus in cultured human melanoma cells. | Varicella-zoster virus (VZV) has been isolated and serially propagated in a continuous cell line derived from a human malignant melanoma tumour. Human melanoma cells (HMC) have been further evaluated as a substrate for the production of cell-free virus and compare favourably with human embryo cells. Within 60 h after i... | 225,414 | [
-0.2746661,
-0.1600867,
-0.1452426,
-0.1424855,
0.2925202,
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0.1040358,
0.1405961,
0.1606592,
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0.24207,
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0.03812013,
0.09565544,
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0.2762161,
0.591931,
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-0.1610443,
0.... |
Polypeptides of bovine rotavirus. | Polyacrylamide gel electrophoresis of bovine rotavirus or neonatal calf diarrhoea virus (NCDV) grown in cell culture resolved eight species of polypeptide. The inner shell particles contained five polypeptides and the outer shell three polypeptides. A major polypeptide of the outer shell was glycosylated. The infectivi... | 225,424 | [
-0.1985557,
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-0.02922305,
0.05081005,
0.2136607,
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0.1116895,
0.01313521,
0.4517322,
0.4112087,
0.07816868,
0.1386057,
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0.07294186,
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-0.1917276,
-0.1296552,
0.168546,
0.2769309,
-0.1788926,
... |
In vitro transformation by bovine papilloma virus. | This paper reports the development of a quantal transformation assay for bovine papillome virus. Support for its specificity to fibropapilloma derived bovine papilloma virus comes from (I) the absence of transformation associated changes following inoculations of normal bovine skin, bovine teat papilloma, bovine teat f... | 225,431 | [
-0.01011497,
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0.03773651,
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0.1071547,
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-0.2036208,
-0.06420411,
0.02418945,
0.04907695,
-0.16508... |
Phenotypic mixing between murine oncoviruses and murine cytomegalovirus. | In vitro interactions between murine cytomegalovirus (MCMV) and murine leukaemia viruses (MuLV), two groups of enveloped viruses capable of causing persistent or latent infections in vivo, were examined for evidence of phenotypic mixing. The growth of MCMV in murine cells productively infected with ecotropic MuLV was s... | 225,436 | [
-0.0880591,
0.1859293,
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-0.1958503,
0.2164157,
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0.1970338,
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0.1657337,
0.4696814,
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0.03730566,
-0.06110448,
0.02655874,
0.2085714,
0.3553153,
-0.1404159,
-0.006947181,
... |
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