title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Possible alpha-adrenergic involvement in nicotine induced alteration of spermatogenesis in rat. | Nicotine caused a fall in primary spermatocyte number together with a retardation of spermatocyte to spermatid conversions process. These effects of nicotine were possibly secondary to increased activity of adrenomedullary catecholamines, since the antispermatogenic effect of nicotine was prevented by phentolamine, a k... | 227,296 | [
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Plasma lipids on chronic uraemic and transplantation patients. | We studied the concentrations of total cholesterol, HDL-cholesterol and triglyceride in the plasma in renal (n = 48) patients. In undialyzed uraemic patients (mean serum creatinine value 439 mumol/l) the plasma cholesterol level was somewhat higher (6.47 mmol/l) than in the control (n = 27) group (5.67 mmol/l). HCL-cho... | 227,315 | [
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Determination of vitamin D and its metabolites in plasma from normal and anephric man. | A multiple assay capable of reliably determining vitamins D(2) and D(3) (ergocalciferol and cholecalciferol), 25(OH)D(2) (25-hydroxyvitamin D(2)) and 25(OH)D(3) (25-hydroxyvitamin D(3)), 24,25(OH)(2)D (24,25-dihydroxyvitamin D), 25,26(OH)(2)D (25,26-dihydroxyvitamin D) and 1,25(OH)(2)D (1,25-dihydroxyvitamin D) in a si... | 227,368 | [
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Effect of 1,4-dimorpholino-7-(4-hydroxyphenyl)pyrido[3,4-d]) pyridazine [DS-511(4'-OH)] on the transepithelial transport of sodium and water and the permeability to urea in the toad urinary bladder. | To elucidate the mechanism of the inhibitory action of 1,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine (DS-511) on water and sodium reabsorption at the renal tubules, the effect of DS-511 (4'-OH), which is similar in diuretic effect to but more water-soluble than DS-511, on the transepithelial transport of sodium and ... | 227,423 | [
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Inhibition of cytomegalovirus-stimulated human cell ornithine decarboxylase by alpha-difluoromethylornithine. | 1. The relationship between synthesis of putrescine, human cytomegalovirus DNA synthesis, cell DNA synthesis, and human cytomegalovirus replication has been studied. 2. Stimulation of ornithine decarboxylase activity by shifting low serum-arrested whole human embryo cells to high serum medium is inhibited more than 99%... | 227,464 | [
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[Metabolic characteristics of prolyl hydroxylase]. | The turnover time of prolyl hydroxylase in the skin of one-day-old rats treated in vivo with L-[14C]leucine is 22--34 hrs. Theoretically this time interval comprises two processes: i. e. incorporation of [14C]-Leu into the inactive enzyme precursor and transformation of the inactive from into the active enzyme. | 227,484 | [
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[Oxidation of 4-anilino-5-methoxydioxybenzene-1,2 in complex biochemical systems possessing superoxide dismutase activity]. | The kinetics of 4-anilino-5-methoxydioxybenzene-1,2 (AMOBQH2) autoxidation in biochemical systems possessing the superoxide dismutase activity were studied. The autoxidation of AMOBQH2 is affected by superoxide dismutase, which is indicative of participation of the superoxide radical in this process. The main kinetic e... | 227,487 | [
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An automated analysis of REM sleep in primary depression. | The REM sleep of 23 nonpsychotic patients with primary depression was studied by means of an automated REM analyzer during a drug-free period and again during amitriptyline administration. Initial drug administration (50 mg) was associated with an immediate reduction in the number, average frequency, and average size o... | 227,488 | [
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[Thymic Kurloff inclusion. Action on the ovogenesis of the rat]. | Grafts and injections of cellular extracts from thymus and spleen of guinea pigs, were carried out in puberal and impuberal female rats. These organs are especially rich in Foa-Kurloff cells after oestrogentherapy. Kidney served as a reference material for the same experimental conditions. Controls received cellular in... | 227,495 | [
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Radiology of the adult sella turcica. | Radiographic changes of the sella turcica or pituitary fossa reflect multiple disease processes of intracranial, cranial and systemic origin. Their value as diagnostic aids is related to the fact that the development of the fossa depends somewhat upon that of the pituitary gland, which it partially encloses. Further, m... | 227,501 | [
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The influence of naloxone on the C fiber response of dorsal horn neurons and their inhibitory control by raphe magnus stimulation. | In intact rats anesthetized with chloralose, the effects of naloxone were studied on the responses of spinal cord dorsal horn neurons to C fiber stimulation and upon the inhibition induced on these responses by stimulation of the nucleus raphé magnus (NRM). (1) A mean 44% facilitatory effect on responses to C fibers wa... | 227,529 | [
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A rapid plaque neutralization test for bluetongue virus. | A bluetongue virus plaque neutralization test, done in small tissue culture wells (2.0 cm2) using minimal antibody-virus contact time, was found to be of comparable sensitivity to more classical methods involving preincubation. By using the cell culture plates as serum dilution wells and adding cells directly to the vi... | 227,553 | [
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The significance of concordance in mammographic interpretations. | Twenty-eight women participating in a screening program had a breast cancer diagnosed subsequent to the report of a negative mammogram which was read by only one of a group of radiologists. Fourteen occurred prior to a scheduled routine screening visit (interval cancers) and 14 were detected during such an examination.... | 227,558 | [
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Inactivation of membrane-bound (Na+ +K+)-ATPase of Yoshida sarcoma cells and cobra venom cytotoxin complex with the glycolipid components of the enzyme system. | The molecular mechanisms involved in the inactivation of (Na+ + K+)-stimulated ATPase of Yoshida sarcoma cells by a cytotoxic protein (P6) from cobra venom have been examined. The overall data obtained using purified (Na+ + K+)-stimulated ATPase of Yoshida sarcoma cells suggest that cytotoxin P6 combines with phosphati... | 227,583 | [
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In vivo infectivity of the fibrotropic C-type viral isolates from C57BL/Ka mice. | Of the three fibrotropic C-type viral isolates from C57BL/Ka mice, only the BL/Ka(B) virus is capable of infecting normal hematopoietic and lymphoid cell populations of C57BL/Ka mice in vivo, and none are tumorigenic. Inoculation of this virus alone into neonates resulted in transient replication in the bone marrow, sp... | 227,584 | [
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Sequence homology of nucleic acids from human breast cancer cells and complementary DNA's from murine mammary tumor virus and Mason-Pfizer monkey virus. | Simultaneous presence of murine mammary tumor virus- and Mason-Pfizer monkey virus-specific sequences has been detected in nucleic acids isolated from some human breast tumors and from MCF-7 cells, a well-characterized human breast cancer cell line. Carefully characterized long complementary DNA transcripts were used i... | 227,595 | [
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High concentrations of free kinins and kinin system components in abdominal transudate of a patient with nephrotic syndrome. | High levels of bradykinin (60--80 ng/ml) were found in abdominal transudate from a patient with nephrotic syndrome caused by chronic glomerulonephritis. The abdominal transudate contained neutral kininogenase and its precursor, identified with plasma kallikrein and prekallikrein, respectively, as well as both forms of ... | 227,622 | [
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[Quantitative analysis of lipoproteins in hyperlipoproteinemias of type IIa, IIb and IV (author's transl)]. | Cholesterol and triglyceride content of serum lipoprotein fractions isolated by ultracentrifugation have been studied in 33 healthy subjects and in 56 subjects affected by hyperlipoproteinemia of type IIa, IIb and IV. Patients with atherosclerotic disease were characterized by a general decrease of HDL cholesterol and ... | 227,624 | [
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An improved method for the determination of acetaldehyde in human blood with minimal ethanol interference. | A sensitive method for the determination of acetaldehyde in human blood is described which involves the derivatization of acetaldehyde with semicarbazide followed by head-space gas chromatographic analysis of acetaldehyde in plasma samples after acid hydrolysis of the semicarbazone derivative. Quantitative recovery of ... | 227,626 | [
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The early clinical presentation of synovial sarcoma. | While synovial sarcoma most commonly presents as a painless mass, occasionally the cancer emerges in a misleading manner resulting in an unfavorable delay or error in diagnosis. A review of the litrature reveals 4 such occult patterns: pretumor phase characterized only by pain or tenderness; the acute inflammatory lesi... | 227,635 | [
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Regulation of transcription by DNA-bound non-histone nuclear proteins. | Purified non-histone proteins from mouse mammary cells bind specifically to homologous DNA or chromatin. Complexes of non-histone protein with DNA or chromatin, isolated on agarose columns, were transcribed with both Escherichia coli RNA polymerase and RNA polymerase B from calf thymus. The fact that complexing of DNA ... | 227,684 | [
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The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation. | 1. The activity of the soluble, calcium-dependent phosphatidylinositol-specific phosphodiesterase (EC 3.1.4.10) against [32P]phosphatidylinositol has been investigated. 2. KC1 (only at neutral pH), Mg2+, positively-charged proteins such as histone, and phospholipids containing a choline headgroup are all inhibitory to ... | 227,685 | [
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Biochemical compartmentation of fish tissues. II. Nonspecific phosphomonoesterases in brain. | The specific activities of acid and alkaline phosphatases in different regions of the brain of 9 nutritionally important fishes were worked out. The region consisting of pituitary, hypothalamus and thalamus showed the highest acid and alkaline phosphatase activities. Least activities of both the enzymes were found in t... | 227,710 | [
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Role of lipoprotein lipase in plasma triglyceride removal. | Intravenous injections of anti-lipoprotein lipase serunis quantitatively block the catabolism of very low density lipoprotein (VLDL) and portomicron triglyceride and specifically inhibit triglyceride transport into ovarian follicles. The immunological studies presented provide information on the site of action of lipop... | 227,752 | [
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[Studies on the heterogeneity of urinary HCG molecules by RRA and RIA (author's transl)]. | A sensitive bioassay (Radio receptor assay: RRA) for urinary hCG which is independent of plasma half life and metabolism has been developed by utilizing the specific binding of 125I-hCG to 150 approximately 2000g fraction of homogenates of the rat testis. The receptor and immunological activity (RRA/RIA) ratio of urina... | 227,758 | [
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Localization of LH receptors on luteal cells with a ferritin--LH conjugate. | In order to study the distribution of LH (HCG) receptors on luteal cells ferritin was coupled to ovine LH with glutaraldehyde and purified by gel chromatography. The conjugate (FELH) competed with 125I-hCG for binding to isolated luteal membranes and stimulated a dose-dependent release of progesterone (P) from isolated... | 227,760 | [
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Studies on cytochrome c oxidase, VI. Polypeptide IV. the complete primary structure. | The complete primary structure of the cytoplasmically synthesized polypeptide IV from beef heart cytochrome oxidase was determined via isolation and sequencing of overlapping methionine, tryptophan, and arginine fragments. The protein consists of 147 amino acids (Mr 17153). It is characterized as a part of a membrane p... | 227,780 | [
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Hemagglutinin mutants of swine influenza virus differing in replication characteristics in their natural host. | In two mutant clones (L and H) of A/NJ/11/76 (Hsw 1N1) influenza viruses which differ slightly antigenically and markedly in replication characteristics in chicken embryos and Madin Darby canine kidney cells, these pleiotropic differences are mediated by mutation in the hemagglutinin gene (E. D. Kilbourne, Proc. Natl. ... | 227,792 | [
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Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon. | Mixed preparations of fibroblast and immune interferons interacted with cells synergistically to cause the development of a much greater level of protection than expected on the basis of their separate activities. This increased level of protection was 5- to 20-fold greater than expected on the basis of a simple additi... | 227,796 | [
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Depression of vaccinal immunity to Marek's disease by infection with reticuloendotheliosis virus. | The effect of infection with low-virulence, tissue culture-propagated strains of reticuloendotheliosis virus (REV) on protective vaccinal immunity against Marek's disease (MD) lymphomas was investigated. Vaccinated chickens inoculated at hatching with greater than 10(4) focus-forming units of REV and challenged with MD... | 227,800 | [
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Photoaffinity inactivation of the enkephalin receptor. | An arylazide enkephalin derivative, [D-Ala2,Met5]enkephalin-Tyr-N-(2-nitro-4-azidophenyl) ethylenediamine (ETN), has been synthesized. In the dark, it inhibited the binding of [3H]enkephalinamide to enkephalin receptor-rich NG-108 cell membranes with an I50 = 2.2 X 10(-8) M or KI = 7 X 10(-9) M, assuming competitive in... | 227,880 | [
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Characterization and comparison of membrane-associated and cytosolic cAMP-dependent protein kinases. Studies on human erythrocyte protein kinases. | Cyclic AMP-dependent protein kinase from human erythrocyte plasma membranes was solubilized with Triton X-100, partially purified, and systematically characterized by a series of physicochemical studies. Sedimentation and gel filtration experiments showed that the 6.6 S holoenzyme had a Stokes radius (a) of 5.7 nm and ... | 227,897 | [
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A new system for studying molecular mechanisms of mutation by carcinogens. | A new system for studying the molecular mechanisms of mutation by carcinogens is described. The system involves (a) site-specific modification of the essential gene G in phi X174 replicative form DNA by a combination of chemical and enzymatic steps; (b) production of mutant virus carrying a change at a single preselect... | 227,905 | [
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Immunofluorescence and electron microscopy of the cytoplasmic surface of the human erythrocyte membrane and its interaction with Sendai virus. | A method was developed for directly observing the inner surfaces of plasma membranes by light and electron microscopy. Human erythrocytes were attached to cover slips (glass or mica) treated with aminopropylsilane and glutaraldehyde, and then disrupted by direct application of a jet of buffer, which removed the distal ... | 227,914 | [
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Inhibition of lipolysis in hamster adipocytes by the cation ionophor X537A. | The present study reports the effects of the lipophylic ionophore X537A on lipolysis and accumulation of cAMP in isolated hamster epidiymal adipocytes. X537A inhibited lipolysis activated with norepinephrine, isoproterenol, dibutyryl cAMP or theophylline but failed to influence basal lipolysis. The minimum effective co... | 227,946 | [
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Target-effector interaction in the natural killer cell system. IV. Modulation by cyclic nucleotides. | Dibutyryl cAMP (dB-cAMP) and the cAMP elevating agents, prostaglandin E1, theophylline, and histamine markedly suppressed NK cytolytic function in a dose- and rate-dependent manner. The inhibition was rapidly induced and persisted in the presence of the drugs. Separate pretreatment of targets and highly purified NK cel... | 227,959 | [
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Characterization of interferon messenger RNA from human lymphoblastoid cells. | After treatment with Sendai virus, Namalwa cells form large amounts of interferon. RNA extracted from treated whole cells or from their polysomes was injected into Xenopus laevis oocytes and the interferon formed was titrated. The results show that the amount of interferon mRNA was maximal by 9 h after treatment of the... | 227,993 | [
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Orthopoxvirus strains defective in surface antigen induction. | Various strains of vaccinia, variola, whitepox, monkeypox and cowpox viruses were examined for their capacity to induce a specific early antigen detectable on the surface of infected cells. The Elstree strain of vaccinia, two strains of variola minor and white variants of cowpox and monkeypox viruses lacked the capacit... | 227,999 | [
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Familial amyloidosis with cranial neuropathy and corneal lattice dystrophy. | Five siblings of a Danish family with slowly progressive involvement of the trigeminal, facial, glossopharyngeal, accessory, and hypoglossal nerves beginning at the age of 55-65 years were examined. All had asymptomatic corneal lattice dystrophy. Clinical and electrophysiological investigations also showed evidence of ... | 228,009 | [
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Diversity of mammary tumor viral genes within the genus Mus, the species Mus musculus, and the strain C3H. | Proviral sequences complementary to the C3H mouse mammary tumor virus RNA genome are present in the DNA of early occurring mammary tumors of C3H/HeN mice and are absent from apparently normal C3H/HeN tissues; these sequences are non-germ line transmitted in C3H/HeN mice and have been termed tumor-associated sequences; ... | 228,059 | [
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Inhibition of Rous sarcoma virus replication by 2-deoxyglucose and tunicamycin: identification of an unglycosylated env gene product. | Two inhibitors of glycosylation, 2-deoxyglucose and tunicamycin, depressed the synthesis of infectious Rous sarcoma virus greater than 100-fold. Under the same conditions only a two- to threefold decrease in the production of virus particles was observed. The noninfectious particles had a lower density (1.145 g/ml) in ... | 228,066 | [
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Hormonal regulation of murine mammary tumor virus RNA expression during mammary tumorigenesis in BALB/c mice. | The effects of glucocorticoids and prolactin on murine mammary tumor virus (MuMTV) RNA expression in preneoplastic outgrowth lines and mammary tumors in BALB/c mice were investigated. Hyperplastic alveolar nodules (HAN) and a ductal hyperplasia (DH) are induced in virgin BALB/c mice by prolonged hormonal stimulation or... | 228,079 | [
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Differential adsorption of polyoma virions and capsids to mouse kidney cells and guinea pig erythrocytes. | Adsorption of 125I-labeled polyoma virions and capsids to the surface of mouse kidney cells (MKC) and guinea pig erythrocytes was examined. Purified polyoma capsids lack the ability to compete with polyoma virions for specific binding sites on the surface of MKC. These same capsids were, however, able to block virion a... | 228,085 | [
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Observations on the epidemiology of the herpesvirus of infectous bovine rhinotracheitis/infectious pustular vulvovaginitis in wildebeest. | Spontaneous vulvovaginitis erupted in wildebeest (Connochaetes taurinus) after betamethasone inoculation. Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV) is probably a venereal disease because virgin wildebeest did not develop vulvovaginitis after betamethasone injections, nor was the vir... | 228,091 | [
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Inhibitory effects of macrophages against Marek's disease virus plaque formation in chicken kidney cell cultures. | Inhibition of plaque formation by Marek's disease virus (MDV) in chicken kidney cell cultures was investigated with the use of peritoneal exudate cells (PEC) from chickens. PEC from MDV-infected White Leghorn chickens inhibited the formation of MDV plaques, whereas the inhibitory effect of PEC from chickens vaccinated ... | 228,107 | [
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5-FU versus combination therapy with tubercidin, streptozotocin, and 5-FU in the treatment of pancreatic carcinomas: COG protocol 7230. | From May 1972 until May 1976, 105 patients were entered on Central Oncology Group protocol 7230 to compare the combination of streptozotocin, tubercidin, and 5-fluorouracil (5-FU) versus 5-FU alone in the treatment of adenocarcinoma and islet cell carcinoma of the pancreas. Twenty-nine were not evaluable. Thirty-six ev... | 228,123 | [
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Modification of the substrate specificity of rat hepatic lipase by collagenase treatment. | Collagenase is currently used in the isolation of rat hepatocytes, but it rapidly inactivates the heparin-releasable triacylglycerol lipase of the liver. Since collagenase-isolated liver cells contain a heparin-releasable monoacylglycerol hydrolase, a study was made on the effect of collagenase treatment on the substra... | 228,127 | [
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Panel discussion: glomus jugulare tumors of the temporal bone. Radiological appearance of glomus tumors. | Depending upon the stage of pathogenesis, some glomus tumors demonstrate characteristic radiographic findings which permit a presumptive diagnosis of this type of tumor. Three factors are helpful in interpreting multidirectional tomography of the temporal bone when a glomus tumor is suspected. The tumor shows a predile... | 228,132 | [
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Reactivity of neutralizing antibodies with different specificities to H particles of poliovirus. | In order to elucidate the antigenic structure of poliovirus, the reactivity of antibody produced with H antigenic particles of Mahoney strain (polio type 1) was investigated. Injection of H particles of Mahoney strain into rabbits yielded neutralizing antibody as well as CF-N and CF-H antibodies. This result coincided ... | 228,166 | [
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Onset of neural function in the lateral line. | The development of the nervous system includes the formation of specific neuronal connections. Some insight into the mechanisms by which these connections are made may be obtained by determining the order in which the elements of a developing system begin to function and examining any changes that may occur in the syst... | 228,196 | [
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Endogenous viral genes are non-essential in the chicken. | DNA sequences homologous to the genomes of type C retroviruses are widespread among vertebrates. Ten genetic loci containing endogenous viral DNA sequences have been documented in the white Leghorn chicken alone. Six of these genetic loci are associated with the production of virus or of viral proteins in embryonic fib... | 228,201 | [
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A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser. | It is generally accepted that morphine exerts its analgesic effect by binding to specific opiate receptors in the brain and spinal cord. Since Hughes et al. isolated and identified two endogenous pentapeptides, Met- and Leu-enkephalin, from the brain and found that they acted as agonists at opiate receptors, alpha-, be... | 228,202 | [
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Plasma glucocorticoid and adrenocorticotropin concentrations measured serially in growth-retarded fetal lambs. | We studied the fetal pituitrary-adrenal axis in 9 growth retarded fetal lambs by serially measuring plasma glucocorticoids and ACTH concentrations from 115 to 140 days of gestation and adrenal blood flow at 138 days of gestation. At each gestational age period studied, plasma glucocorticoid and ACTH concentrations were... | 228,234 | [
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Nicking-closing enzyme is associated with SV40 DNA in vivo as a sodium dodecyl sulfate-resistant complex. | A fraction of the cellular nicking-closing (NC) enzyme cosediments with SV40 chromatin isolated after Triton X-100 treatment of infected cells nuclei. Extraction of viral DNA according to the Hirt procedure by treatment of infected cells with sodium dodecyl sulfate (SDS) followed by sedimentation in sucrose gradient to... | 228,247 | [
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... |
Non-specific interactions of CRP from E. coli with native and denatured DNAs: control of binding by cAMP and cGMP and by cation concentration. | The cyclic adenosine 3',5'-monophosphate receptor protein of Escherichia coli (CRP) binds cooperatively to single- and double-stranded DNA. Binding data could be fitted to the model of McGhee and von Hippel (1) and show that neither strandedness of DNA, nor the effectors cAMP and cGMP or the ionic strength (KCl) do cha... | 228,253 | [
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... |
Triplet states in photosystem I of spinach chloroplasts and subchloroplast particles. | We report light-induced electron paramagnetic resonance triplet spectra from samples of chloroplasts or digitonin photosystem I particles that depend upon the dark redox state of the bound acceptors of photosystem I. If the reaction centers are prepared in the redox state P-700 A X- FdB-FdA-, then upon illumination at ... | 228,280 | [
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Catabolite inactivation of gluconeogenic enzymes in mutants of yeast deficient in proteinase B. | Strains of Saccharomyces cerevisiae bearing nonsense mutations in the structural gene for proteinase B (EC 3.4.22.9) have been examined for the ability to make the transition from growth on acetate to growth on glucose and for the ability to inactivate three glucoeogenic enzymes during the transition because proteinase... | 228,302 | [
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Auditory arousal thresholds of good sleepers and poor sleepers with and without flurazepam. | Auditory arousal thresholds of good (N = 12) and poor (N = 12) sleepers (sleep onset insomniacs) were obtained during stage 2, stage 4, and REM sleep at various times of the night. Despite claims of being "light" sleepers who are easily awakened by noise, poor sleeper auditory arousal thresholds were the same as those ... | 228,373 | [
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[Decrease of the erythrocyte filterability and cerebrovascular accidents. Study in eighty patients (author's transl)]. | Erythrocyte filterability has been studied in 80 patients (44 men and 36 women) with recent stroke (mean age of patients was 68). 200 adults were studied as reference. The filtration time is significantly higher in patients than in normal subjects (p less than 0,001). High individual variations are found in patients, i... | 228,402 | [
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[Calcification and hernia of an intervertebral disc in a child (author's transl)]. | Cervicobrachial neuralgia and torticolis in a 7 year old child were found to be due to calcification and hernia of an intervertebral disc. Similar cases reported in the published literature are reviewed. | 228,428 | [
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Surgical treatment of adenoid cystic carcinoma of the left main bronchus and trachea by left pneumonectomy, resection of 7.5 cm of trachea, and direct reanastomosis of right lung. | A 23-year-old woman, who had suffered recurrent acute bronchitis, dyspnoea, and stridor, was found to have a tracheal stenosis and complete left main bronchus obstruction. Biopsy of the tumour showed an adenoid cystic carcinoma. After pneumonectomy the trachea was closed through tumour tissue. Two weeks later a right t... | 228,443 | [
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0... |
[Purification of coronaviruses from contaminated cattle feces]. | A scheme was worked out for the obtaining of purified Corona viruses from fecal extracts, which include: centrifugation in an discontinued gradient of sucrose 20--45 per cent, gel filtration through a Sephadex 4B column, and centrifugation in a linear gradient of sucrose 10--50 per cent. By means of such purification t... | 228,473 | [
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0... |
[Copper-containing brain proteins]. | Three copper-containing proteins were obtained from bovine brain soluble fraction. Two of them were purified to electrophoretically homogenous states. Some physicochemical properties of these proteins were studied. From mitochondrial fraction of grey matter of bovine brain cytochrome oxidase was obtained, which was sim... | 228,492 | [
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... |
[Properties and isoenzyme contents of glucose-6-phosphatase of normal and tumor cell microsomes]. | Studies on the properties and isoenzymic content of glucose-6-phosphatase (E. C. 3.1.3.9.) of normal and tumor cells microsomes allowed the following conclusion to be made: the localization of the enzyme in the membranes of endoplasmatic reticulum of both types of cells is identical. The tumor microsomes are characteri... | 228,495 | [
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0.1271192,
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The pathologic assessment of primary hyperparathyroidism and its impact on therapy. A prospective evaluation of 50 cases with oil-red-O stain. | Normal and abnormal parathyroid glands removed surgically from 50 consecutive patients with primary hyperparathyroidism were studied by means of hematoxylin and eosin and oil-red-O stains. This was done to establish the incidence of the different pathological entities in our patient material, and to evaluate the role o... | 228,618 | [
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Emerging patterns of hepatitis B chronic liver disease in Australia. | Until now, the hepatitis B virus has been thought to play a minor role in the aetiology of chronic liver disease in Australia. This is a report of 21 patients with cirrhosis and/or primary hepatocellular carcinoma with hepatitis B antigenaemia. Primary hepatocellular carcinoma occurred in six patients, five of whom had... | 228,647 | [
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0.2678886,
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Maternal immunosuppression and cytomegalovirus infection of the fetus. | Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE). Serology showed that maternal CMV infection had been acquired at least four months before pregnancy. Screening f... | 228,648 | [
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0.0785331,
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0.03018966,
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Tri-iodothyronine-induced increase in rat liver nuclear thyroid-hormone receptors associated with increased mitochondrial alpha-glycerophosphate dehydrogenase activity. | The effect of tri-iodothyronine injection on the nuclear tri-iodothyronine receptor (putative thyroid-hormone receptor) was examined in rat liver. Nuclear receptors were extracted from isolated nuclei with 0.4 M-KCl, and their association constants (Ka) and maximal binding capacities (Cmax.) were determined by Scatchar... | 228,651 | [
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Changing pattern of cyclic AMP-binding proteins during germination of Mucor racemosus sporangiospores. | Interation of cyclic AMP with a profoundly changing pattern of specific binding proteins was shown during aerobic germination of sporangiospores from the fungus Mucor racemosus. 32P-labeled 8-azido-cycli AMP, an analogue of cyclic AMP that forms a covalent linkage with the binding proteins under u.v. light, was used as... | 228,658 | [
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... |
An analysis of the influences of maternal age, gestational age, contraceptive method, and the mode of primary treatment of patients with hydatidiform moles on the incidence of subsequent chemotherapy. | In relation to the total number of births in the United Kingdom there was an excess of hydatidiform moles arising in women over 34 years of age and possibly also under 15. The incidence of trophoblastic tumour requiring chemotherapy after hydatidiform mole was greatest in the 30 to 34 years age group and it was also hi... | 228,696 | [
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0.5522026,
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Enzymatic properties of 8-bromoadenine nucleotides. | 8-Bromoadenine nucleotides were tested as potential substrates and/or inhibitors of mitochondrial processes in intact or disrupted organelles, as substrates of various phosphotransferases, and as allosteric effectors in the reactions catalyzed by phosphofructokinase, isocitrate dehydrogenase, glutamate dehydrogenase, a... | 228,699 | [
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-... |
Possibility of shape conformers of the protein inhibitor of the cyclic adenosine monophosphate dependent protein kinase. | The heat-stable, protein inhibitor of the cyclic adenosine monophosphate (cAMP) dependent protein kinase [Walsh, D. A., Ashby, C. D., Gonzalez, C., Calkins, D., Fischer, E., & Krebs, E (1971a) J. Biol. Chem. 246, 1977-1985] has been purified to homogeneity from rabbit skeletal muscle by preparative electrophoresis.... | 228,700 | [
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0.26... |
The oxygen reactions of reduced cytochrome c oxidase. Position of a form with an unusual EPR signal in the sequence of early intermediates. | The order of appearance of intermediates in the reoxidation of reduced cytochrome c oxidase by oxygen has been examined. Particular emphasis was placed on determining where the intermediate with the EPR signal at g = 5, 1.78, 1.69 (Shaw, R.W., Hansen, R.E. and Beinert, H. (1978) J. Biol. Chem. 253, 6637--6640) appears ... | 228,710 | [
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... |
Maturation of replicating simian virus 40 DNA molecules in isolated nuclei by continued bidirectional replication to the normal termination region. | Mature SV40 DNA synthesized for different periods of time either in isolated nuclei or in intact cells was highly purified and then digested with restriction endonucleases in order to relate the time of synthesis of newly replicated viral DNA to its location in the genome. Replication in nuclei supplemented with a cyto... | 228,728 | [
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Studies on the neurochemical properties of cystathionine. | Following the intracerebral administration of [35S]cystathionine, the synaptosome fraction of rat brain was labelled, the greatest uptake of amino acid being associated with hypothalamus. The uptake of [35S]cystathionine by synaptosome preparations isolated from different regions of brain, was typical of that exhibited... | 228,759 | [
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0.1079989,
... |
[Possible role of SV40 T antigen in cell transformation]. | The effect of purified SV40 T antigen on DNA synthesis in isolated nuclei from the confluent culture of CV-1 cells was studied. In the presence of T antigen the incorporation of [3H]TTP into DNA was found to be 2 to 3 times as high as in the control nuclei. The resulting labelled DNA was subjected to alkaline sucrose g... | 228,772 | [
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... |
PRL and ACTH secretion following acute heat exposure, in intact and in hypothalamic deafferentated male rats. | Adult male rats, intact or bearing complete, anterior or posterior hypothalamic deafferentiations (CHD, AHD AND PHD, respectively) were acutely exposed to environmental temperature of 36 degrees C, and serum PRL and ACTH concentrations were determined by RIA. In intact animals, heat exposure resulted in elevated serum ... | 228,794 | [
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Structure and dynamics of neural network oscillators. | Techniques are given to represent oscillating neural networks by asynchronous logical switching networks, and to analyze the oscillating networks using a directed graph called a state transition diagram. Consideration is restricted to network oscillators containing no rhythm determining pacemaker neurons, and no neuron... | 228,804 | [
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Study of an asymmetric ESR signal in x-irradiated human tooth enamel. | An asymmetric ESR signal and an outer doublet signal centered at g = 2.00 produced in human tooth enamel by X-irradiation have been studied over a temperature range from liquid helium temperature to 380 degrees K. The line shape of the asymmetric signal for an enamel crystallite is Lorentzian at room temperature. The t... | 228,823 | [
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0.0162... |
An opiate receptor on frog sciatic nerve axons. | The effect of meperidine (3 X 10(4) M) on the action potential of frog sciatic nerve was examined by means of the double sucrose gap technique. Meperidine decreased the amplitude, maximum rate of depolarization, and maximum rate of repolarization of the action potential but had no effect on the resting potential. This ... | 228,829 | [
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0.... |
Glycolytic enzyme activities in malignant cells grown in vitro and in vivo. | Cell proximity has a profound effect on the glycolytic enzyme levels observed in mammalian cells grown in vitro. Hexokinase activity generally increased with the increasing cell density of both untransformed and virus-transformed cultures. In contrast, phosphofructokinase and pyruvate kinase activities were generally e... | 228,848 | [
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... |
Glomus tumor treated by prostaglandin inhibition. Report of a case. | Glomus tumor is a very painful pericytal lesion of the arteriovenous anastomotic complex that controls circulation in a limb. Glomus tumor usually involves a digit. Prostaglandin inhibition may control the glomus tumor pain, but surgical removal is the cure. When the condition is discovered early, or when there is no g... | 228,884 | [
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0.1339162,
-0.5346754,
-0.44141,
-0.1408438,
0.02931114,
-0.2293455,
-0.1345535,
0.3760415,
-0.2218659,
0.1172553,
0.3098482,
-0.117085,
-0.1959995,
-0.1954087,
0.03891073,
-0.2297078,
0.01150665,
0.1964491,
0.2331499,
0.2204485,
0.1992473,
-0.03379545,
0.55... |
Corticosteroidogenesis by isolated human adrenal cells: effect of serotonin and serotonin antagonists. | The direct effect of serotonin and antiserotonin agents on adrenal steroid biosynthesis was studied in isolated adrenal cells derived from patients with Cushing's syndrome. The results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress ad... | 228,968 | [
-0.1798816,
-0.05450751,
-0.2324856,
-0.05608608,
0.01481284,
0.05461224,
-0.3267083,
0.1964337,
0.1644686,
0.2296354,
0.1591056,
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-0.08617591,
0.1183939,
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-0.1035556,
0.1719236,
0.04910225,
0.2882395,
0.1430104,
0.134284,
-0.09181992,
... |
Studies on the protein composition of human serum very low density lipoproteins: demonstration of the beta 2-glycoprotein-I. | Human serum VLDL isolated by polyanion precipitation and ultracentrifugation have been delipidated with ethanal/diethyl ether. By electrophoresis in 10% polyacrylamide gels containing 8M urea, we found a protein which comigrated with apolipoprotein E. This protein was purified by column chromatography and turned out to... | 229,068 | [
-0.2413425,
-0.002447477,
-0.1759353,
-0.2144632,
0.2942618,
-0.2499487,
-0.457027,
0.0723341,
0.2527739,
0.1536245,
-0.006794945,
-0.1469774,
0.1816292,
0.008839759,
-0.1261259,
0.02550329,
-0.4540972,
-0.03879889,
-0.01985453,
0.2923707,
0.005464599,
0.07998838,
-0.2209... |
Invasive lobular carcinoma of the breast: incidence and variants. | The criteria for the separation of invasive lobular and ductal carcinomas are analysed. Lobular tumours account for 14% of invasive cancers in our material. The widely differing figures given in the literature are mainly attributable to intrinsic difficulties of classification. In addition to the classical dissociated-... | 229,072 | [
-0.09909845,
0.2170842,
0.2517041,
-0.4692871,
-0.05934189,
-0.6265838,
-0.04399951,
-0.07169025,
0.03119218,
0.3674898,
0.005814611,
-0.100471,
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0.03629346,
0.01696917,
-0.4028085,
-0.2583111,
-0.04476298,
0.3697347,
-0.2000931,
0.4821728,
0.3012993,
-0.194770... |
Effect of leukocyte hydrolases on bacteria. XIII. Role played by leukocyte extracts, lysolecithin, phospholipase a2, lysozyme, cationic proteins, and detergents in the solubilization of lipids from Staphylococcus aureus and group A streptococci: relation to bactericidal and bacteriolytic reactions in inflammatory sites... | The bactericidal and bacteriolytic effects of lysolecithin (LL) and egg-white lysozyme (LYZ) on Staph. aureus and group A streptococci and the solubilization of phospholipids from the bacterial membranes by these agents was studied. Low concentrations of lysolecithin (1--10 microgrames/ml) are highly bactericidal for S... | 229,078 | [
0.1989998,
-0.08094695,
0.02612395,
0.2483067,
0.09064705,
-0.2089271,
-0.3796394,
-0.01752624,
0.0573804,
0.2165268,
-0.1646967,
0.2681808,
-0.01799043,
0.2139727,
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0.1807613,
-0.5055403,
-0.2311348,
-0.2141309,
0.3616306,
0.3943889,
0.1544326,
-0.01811897,
... |
Subunits of cytochrome a-type terminal oxidases derived from Thiobacillus novellus and Nitrobacter agilis. | Cytochrome a-type terminal oxidases derived from Thiobacillus novellus and Nitrobacter agilis have been purified to a homogeneous state as judged from their electrophoretic behavior and their subunit structures studied by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The T. novellus enzy... | 229,103 | [
-0.3915077,
0.1209933,
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0.203072,
0.01548625,
-0.2972733,
0.01992705,
-0.119338,
0.1446492,
0.115532,
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0.1062035,
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-0.2348776,
0.1073074,
-0.5087943,
0.004917261,
0.4035297,
-0.2455483,
-0.02817041,
0.06338072,
-0.1932495,
0... |
Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins. | Mouse peritoneal macrophages accumulate large amounts of cholesteryl ester when incubated with human low-density lipoprotein that has been modified by chemical acetylation (acetyl-LDL). This accumulation is related to a high-affinity cell surface binding site that mediates the uptake of acetyl-LDL by adsorptive endocyt... | 229,107 | [
-0.008545578,
0.3013542,
-0.1332756,
0.1993977,
0.2971929,
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0.106665,
0.3547884,
0.01869162,
0.04795797,
0.08074252,
-0.02490104,
0.05246336,
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0.2925821,
-0.57017,
-0.06837916,
0.1434561,
0.3110556,
-0.1547445,
0.2355142,
-0.2170784,
0.... |
Selective high metabolic lability of uridine, guanosine and cytosine triphosphates in response to glucose deprivation and refeeding of untransformed and polyoma virus-transformed hamster fibroblasts. | Sugar deprivation of hamster fibroblasts (NIL) affected the steady state levels (pool sizes) of cellular acid soluble nucleotides in the folloing fashion: the pools of UTP, GTP and CTP decreased to a much greater extent than the cellular ATP pools, with the UTP pools undergoing the most dramatic reduction. Sugar depriv... | 229,115 | [
0.08894201,
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0.1760927,
-0.4068701,
-0.2558572,
0.2416322,
0.08826345,
0.1183066,
0.1803517,
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0.2290453,
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-0.1571382,
-0.2677847,
-0.05326768,
0.1463101,
0.2495968,
-0.04648517,
-0.1983822,... |
Counterimmunoelectroosmophoresis for detection of neonatal calf diarrhea coronavirus: methodology and comparison with electron microscopy. | A counterimmunoelectroosmophoresis (CIE) technique is described for the detection of calf diarrhea coronavirus antigens in intestinal contents. The antibody reagent was prepared in rabbits against the Nebraska calf diarrhea coronavirus adapted to Vero cells and purified by density gradient centrifugation. The method wa... | 229,123 | [
-0.332149,
-0.3442576,
-0.1822072,
0.08740499,
0.1889565,
0.08231995,
-0.4380432,
0.02059133,
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0.1327166,
0.1172706,
0.1244481,
0.2834913,
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-0.3252478,
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-0.6870044,
-0.2168512,
0.1584642,
-0.0899017,
-0.1281655,
-0.07782113,
-0.1029714,
... |
Possible origin of the bluetongue epidemic in Cyprus, August 1977. | Possible origins of an epidemic of bluetongue in Cyprus in August 1977 have been analysed. First outbreaks occurred simultaneously in the south-east of the Famagusta district and on the north coast of the Kyrenia district respectively. Although the epidemic was due to type 4, which had been responsible for the previous... | 229,164 | [
-0.2628865,
-0.08614838,
-0.0741023,
-0.140715,
-0.06050806,
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-0.3266597,
-0.3008487,
-0.1542723,
0.0784892,
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-0.3278631,
0.02944897,
-0.2266709,
-0.4058636,
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-0.03263833,
0.313298,
0.2657094,
-0.2251472,
0.3928623,
0.2399424,
-0.1288918,... |
Immobilization of viral antigens on filter paper for a [125I]staphylococcal protein A immunoassay: a rapid and sensitive technique for detection of herpes simplex virus antigens and antiviral antibodies. | A new technique is described for the rapid detection and quantitation of herpes simplex virus (HSV) antigens and antiviral antibodies. It involves immobilization of HSV antigens on filter paper discs and subsequent analysis by 125I-labeled staphylococcal protein A (SPA) radioimmunoassay. A specially designed 96-well fi... | 229,166 | [
0.02722632,
-0.007298419,
0.1965992,
0.05060666,
0.138818,
-0.007808511,
-0.1481306,
0.371934,
0.2520674,
0.09846164,
0.161516,
-0.1585565,
0.2397711,
-0.02475864,
-0.02981134,
-0.03541031,
-0.257346,
-0.1969691,
-0.06467541,
0.2163859,
0.3401759,
-0.2020774,
-0.2733873,
... |
Antibody to varicella-zoster virus-induced membrane antigen: immunoperoxidase assay with air-dried target cells. | A technique using indirect immunoperoxidase antibody to membrane antigen (IPAMA) was developed for detection of IgG antibody to varicella-zoster virus (VZV). The IPAMA technique utilizes glass slides with air-dried VZV-infected cells, which can be stored at -70 C and used for several months without loss of sensitivity.... | 229,177 | [
-0.05372914,
-0.3687671,
0.06103135,
0.09024905,
-0.04176863,
0.2719862,
-0.06696424,
0.3745852,
0.07027271,
-0.1005255,
0.3046712,
0.1673654,
0.1898457,
-0.37725,
-0.419008,
-0.1899208,
-0.3211574,
0.09242564,
-0.2655244,
0.1004919,
0.3370196,
0.001290506,
-0.08726536,
... |
Morphological, immunocytochemical and biological characteristics of experimental rabbit brain tumors in tissue culture. | Brain tumors were induced in 3-month-old rabbits of either sex by repeated intravenous injections of N-methyl-N-nitrosourea. Twelve brain tumors (6 pleomorphic gliomas, 5 grade 2--3 astrocytomas, 1 grade 2--3 oligodendroglioma) were established in culture and, with the exception of 2 neoplasms, were propagated in vitro... | 229,201 | [
-0.06267896,
-0.03719291,
-0.321793,
-0.6576329,
0.3664508,
-0.1689119,
-0.1253803,
-0.1615778,
-0.1408362,
0.1886894,
-0.0299861,
0.09535391,
-0.03719588,
-0.03033484,
-0.273888,
-0.1185453,
-0.2074717,
0.2010856,
0.134779,
0.3747587,
0.4285096,
0.3501347,
-0.1660631,
... |
Bacterial lipopolysaccharide depresses spontaneous, evoked, and ionophore-induced transmitter release at the neuromuscular junction. | The neurotoxocity of RNA-free lipopolysaccharide (LPS) extracted from Salmonella Typhimurium (SR-11) was tested at the frog neuromuscular junction using intracellular recording techniques. Spontaneous miniature endplate potential (MEPP) frequency was reduced to 45% of control after 60 minutes in the presence of 10 and ... | 229,236 | [
0.01790711,
-0.08079076,
-0.2015703,
-0.2504893,
-0.1740141,
-0.3546291,
-0.3662249,
-0.03289818,
0.2192547,
0.005511508,
0.1290268,
0.147526,
0.1567387,
-0.1089471,
-0.477663,
0.103927,
-0.3724152,
-0.08480241,
0.1216548,
-0.1956056,
0.1518111,
-0.08655654,
0.2470754,
... |
New classes of viable deletion mutants in the early region of polyoma virus. | Viable mutants of polyoma virus have been isolated which have deletions in defined parts of the early region of the genome. One class of mutants has deletions (less than 1% of viral genome length) located between 71.5 and 73.5 on the physical map of polyoma virus DNA, near the origin of replication. These mutants appea... | 229,246 | [
-0.2333514,
-0.1089412,
-0.1369286,
-0.1602771,
0.1773502,
-0.1411101,
0.1508177,
-0.03001691,
0.2674356,
0.2180398,
0.1897697,
-0.2394562,
-0.1381273,
0.1556291,
-0.4532851,
0.2712571,
-0.178368,
0.1877728,
0.1400589,
0.1645031,
0.4053053,
0.2058407,
-0.1509164,
-0.003... |
Molecular cloning of the Harvey sarcoma virus closed circular DNA intermediates: initial structural and biological characterization. | Supercoiled Harvey sarcoma virus (Ha-SV) DNA was extracted from newly infected cells by the Hirt procedure, enriched by preparative agarose gel electrophoresis, and digested with EcoRI, which cleaved the viral DNA at a unique site. The linearized Ha-SV DNA was then inserted into lambda gtWESlambda B at the EcoRI site a... | 229,252 | [
-0.09774116,
0.05134436,
-0.5396676,
-0.4764688,
0.1417748,
-0.3639971,
-0.1523253,
0.0546442,
0.4009325,
0.08966336,
-0.06618128,
0.02865788,
-0.003418184,
0.1269418,
-0.45412,
0.4466228,
-0.08532318,
-0.007469524,
0.3353347,
-0.0681823,
0.1886623,
0.1490278,
-0.4263566,... |
The 55K protein on the 5' termini of adenovirus type 2 DNA is unrelated to virus-coded candidate transformation proteins (E1-53K, E1-40K-50K) and DNA-binding proteins (E2-42K/47K/73K). | A polypeptide of 55,000 daltons (55K) is linked, probably covalently, to the K' termini of adenovirus type 2 DNA. The 55K polypeptide is synthesized during early stages of infection (T. Yamashita, M. Arens, and M. Green, J. Virol. 30: 497-507, 1979) and thus may function in viral DNA replication, gene regulation, or ce... | 229,254 | [
-0.3301394,
-0.01078594,
-0.1169651,
-0.2613907,
0.0301445,
-0.08874544,
0.007175487,
0.1057751,
0.2926546,
0.1484129,
0.2261036,
0.1443055,
0.06521939,
0.05233013,
-0.6341459,
-0.02715452,
-0.4791956,
0.01167502,
-0.05225851,
0.02567473,
0.1530006,
0.04100985,
-0.2569886... |
The nonstructural component of the Abelson murine leukemia virus polyprotein P120 is encoded by newly acquired genetic sequences. | The Abelson leukemia virus (AbLV) polyprotein P120 is compared to translational products representing the entire Moloney murine leukemia virus (MuLV) genome on the basis of [35S]methionine tryptic peptide composition. Three methionine-containing tryptic peptides present in Moloney Pr65gag are each shown to be present i... | 229,259 | [
-0.4350537,
-0.03175827,
-0.4246611,
-0.3096603,
0.0905415,
0.001920868,
0.1584106,
0.252349,
0.2265394,
0.3644368,
0.05327529,
0.08024909,
0.07004017,
0.02299898,
0.09314998,
-0.1348568,
-0.2500112,
0.2588147,
0.1524491,
0.06767654,
0.1618588,
0.05572514,
-0.02034795,
... |
Simian virus 40 small t antigen is not required for the maintenance of transformation but may act as a promoter (cocarcinogen) during establishment of transformation in resting rat cells. | Simian virus 40 deletion mutants affecting the 20,000-dalton (20K) t antigen and tsA mutants rendering the 90K T antigen temperature sensitive, as well as double mutants containing both mutations, induced host DNA synthesis in resting rat cells at the restrictive temperature. Nonetheless, the deletion mutants and doubl... | 229,274 | [
-0.0186551,
-0.170918,
0.1304071,
-0.03584294,
0.04360916,
-0.0409466,
0.1531529,
-0.08399674,
0.2321489,
0.07770074,
0.3354563,
-0.03473716,
0.02595746,
0.08078472,
-0.5531868,
0.1132948,
-0.3363694,
-0.1518848,
0.02150393,
0.2125269,
0.02756509,
0.40284,
-0.1482553,
-... |
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