title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Differential diagnosis of infant botulism. | Clinical investigations of infants hospitalized with botulism demonstrate a remarkable uniformity of complaints and physical findings. Constipation precedes a course of progressive weakness and cranial nerve dysfunction. Examination reveals hypotonia, hyporeflexia, and a variable pattern of involvement of the motor cra... | 233,167 | [
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Bilirubin excess, erythrophages and siderophages in differentiation of blood in cerebrospinal fluid. | Non-artificial blood admixture in cerebrospinal fluid (CSF) can be proven by demonstrating siderophages and 'bilirubin excess'. Bilirubin excess exists when the bilirubin concentration measured in the CSF exceeds the expected CSF bilirubin concentration. The expected CSF bilirubin concentration is calculated by multipl... | 233,209 | [
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Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. | The actions of thromboxane B2 on various parameters of cardiac performance were studied using the isolated perfused rat heart model. In concentrations from 100 pg/ml to 1 microgram/ml TXB2 significantly reduced the total generated myocardial contractile force. These changes were usually associated with an increase in t... | 233,217 | [
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[Diagnostic value of serum angiotensin converting enzyme activity in sarcoidosis (author's transl)]. | Serum angiotensin converting enzyme activity was measured in 60 blood donors and 100 patients with sarcoidosis histologically confirmed using a spectrophotometric assay with hippurylhistidylleucine as substrate. Sex related differences in the enzyme activity could not be observed. ACE was found to be markedly raised ab... | 233,224 | [
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Demonstration of cells with Marek's disease tumor-associated surface antigen in chicks infected with herpesvirus of turkey, O1 strain. | The presence of Marek's disease tumor-associated surface antigen (MATSA) was demonstrated by the direct and indirect membrane immunofluorescent tests, in chicks inoculated 7-10 days earlier with herpesvirus of turkeys (HVT), O1 strain. In in vitro cultures of spleen lymphocytes and ovaries obtained from these chicks, M... | 233,228 | [
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Skin ulceration associated with herpesvirus infection in cats. | Three cases of skin ulceration in cats are described. Herpesvirus was isolated from the ulcers. Treatment of one case with antibiotics and an antiviral agent was successful. The significance of the viral isolate is discussed. | 233,275 | [
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Experimental transmission of bovine papilloma virus (BPV) extracted from morphologically distinct teat and cutaneous lesions and the effects of inoculation of BPV transformed fetal bovine cells. | Bovine papilloma virus (BPV) was extracted from five cattle each affected with only one of five morphologically distinct lesion types. When inoculated into experimental calves either by scarification or intradermal injection, the BPV extracts produced lesions macroscopically and microscopically similar to those from wh... | 233,276 | [
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Histological and histoenzymological studies of medulla oblongata of Taphozous melanopogon Temminck (a Microchiroptera). | The paper deals with the histological and histoenzymological studies of the medulla oblongata of Taphozous melanopogon Temminck (a microchiropteran bat). Three phosphatases, namely acid phosphatase (ACP), thiamine pyrophosphatase (TTP) and glucose-6-phosphatase (G-6-P) were studied. All the enzymes were seen in all the... | 233,283 | [
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Development, reactivity and GFA immunofluorescence of astroglia-containing monolayer cultures from rat cerebrum. | This report describes detailed protocols for the dissociation, seeding and growth in vitro of monolayer cultures derived from neonatal rat cerebrum. Primary cultures derived by using different seeding densities and in vitro ages were examined qualitatively and quantitatively for morphological composition in terms of tw... | 233,314 | [
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Treatment of the Lennox syndrome with ACTH: a clinical and electroencephalographic study. | In 45 cases of Lennox syndrome treated with ACTH, the immediate and long-term effects and the various factors affecting them were investigated by a follow-up study. 1) Regarding the immediate effect, 23 (51.1%) of the 45 cases became "seizure free" for over 10 days. 2) As to the long-term prognosis of these 23 cases, 1... | 233,337 | [
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[Histoenzymatic research and internal irradiation. V. Histochemical modifications in rat liver with the use of colloidal Au198]. | The histochemical behaviour of succinic dehydrogenase, isocitric dehydrogenase, acid phosphatase and acetylglucosaminidase activities was studied in rat liver treated with Au198-colloidal. In these experimental conditions it was found that the hepatocytes present changes in the enzymatic activities examined, generally ... | 233,345 | [
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Myxoid variety of malignant fibrous soft tissue histiocytoma. | Three cases of the myxoid variety of malignant fibrous histiocytoma (I.F.M.) of the soft tissues are reported. This condition should be recognised as a separate entity differing from other benign pseudosarcomatous or malignant lesions of the soft tissues in that the myxoid component is present not as an occasional back... | 233,373 | [
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[Usage of the gel filtration method for the determination of urinary proteins (author's transl)]. | The urinary proteins determination was carried out after purification by gel filtration over Sephadex rosin. The proteins eluaded react with Biuret-reagent to establish the coloured copper-proteins complex. If proteins concentrations is inferior, the proteins can be determinated by the copper-proteins complex isolation... | 233,432 | [
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[Double blind study of tiapride in neoplasia-related pains (author's transl)]. | The antalgic effects of tiapride used by intravenous way have been evaluated in a randomized study on 30 patients with neoplasia-related pains. We noticed a partial or a complete positive response in 60 % of the cases when tiapride is given at a dose of 300 mg/day. The average efficient period was about four hours. Tol... | 233,444 | [
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[Adrenal cortical adenoma and arterial hypertension. Adrenal vizualisation by scintillation with 131 I 19 iodo cholesterol (author's transl)]. | A case of adrenal cortical adenoma and arterial hypertension is reported. We emphasize interest of scintillation scanning with 131 I 19 iodo cholesterol, worth of routine examination when seeking for these tumors. | 233,450 | [
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[Hematological observations in patients following immunostimulation through intrapleural application of Corynebacterium parvum]. | The Ludwig Lung Cancer Study Group aims to investigate the role of immunotherapy as adjuvant treatment modality in operable non-small cell bronchial carcinoma. The participants are 12 european clinics and institutes. With a proven accrual of 350 patients per year the group offers a sharp tool in clinical oncology with ... | 233,458 | [
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Origin of mitochondrial enzymes. V. The polypeptide character and the biosynthesis of rat liver cytochrome c oxidase polypeptides by mitochondria. | Isolated rat liver mitochondria were labeled in vitro with L-[14C]leucine. Sixty percent of the incorporated radioactivity was found to reside in subunits 1, 2, and 3 of cytochrome c oxidase with apparent molecular weights of approximately 33,000, 25,000, and 20,000, respectively. The results indicate that these are th... | 233,469 | [
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Presence of tolyl-specific IgE and absence of IgG antibodies in workers exposed to toluene diisocyanate. | Independent immunoenzymatic and radioimmunoassay techniques indicated the absence of tolyl-specific IgG antibodies in sera from 25 workers with long-term exposure to toluene diisocyanate (TDI). Five of these workers were clinically hypersensitive to TDI and displayed significant titers of tolyl-specific IgE antibodies ... | 233,473 | [
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Parainfluenzavirus upper respiratory tract illnesses in partially immune adult human subjects: a study at an Antarctic station. | Outbreaks of respiratory tract illnesses (RTI) in adult humans during October and November 1975 at McMurdo Station, Antarctica, were investigated by viral isolation and serologic procedures. The recovery of viral agents was enhanced by use of cell cultures in the field. Recoveries of parainfluenzaviruses types 1 and 3 ... | 233,480 | [
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[A thousand obstetrical sutures of the perineum using a slow absorption synthetic suture material (author's transl)]. | A thread which is absorbed slowly and which has a polyglycolic acid base has been used since 1975 in the Sainte-Foy-les-Lyon Maternity Unit to sew up episiotomies and perineal tears. The authors had 98.70 p. 100 of excellent results out of 1082 cases from the anatomic, aesthetic and functional angle. This technique app... | 233,489 | [
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The synthesis and metabolism of the lipoproteins implicated in atherosclerosis. | The basic concepts of lipoprotein biogenesis and metabolism have been briefly reviewed. Emphasis has been placed upon the distinctive roles of the liver and intestine in apolipoprotein synthesis and delivery, upon the complex interchange of lipids and apolipoproteins between lipoproteins which accompanies nascent lipop... | 233,550 | [
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Electrolyte transport across a simple epithelium. Steady-state and transient analysis. | A simple transporting epithelium is represented as a cellular compartment, compliant in all dimensions, and a paracellular channel, of arbitrary shape, between well-stirred mucosal ans serosal baths. The equations for mass balance, Poiseuille flow, and the Nernst-Planck equation are used to describe the continuous beha... | 233,579 | [
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Adriamycin-induced antitumor response in lethally irradiated mice. | Lethally irradiated mice pretreated with a wide range of Adriamycin (ADM) doses were tested for their in vivo antitumor response against transplanted lymphoma cells. Tumor growth, as assessed by 125IUdR uptake, was markedly impaired by treatment with ADM by a variety of different administration schedules. This ADM-indu... | 233,585 | [
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Growth and skeletal development of the pig. | Growth and skeletal development of the domestic pig (Swedish landrace and Yorkshire) are reported and the weight curve of males from birth to maturity included. Other parameters were tooth development and growth of certain bones. It was concluded that daily weight gain increases rapidly to an age of about 5 months. Sex... | 233,594 | [
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Osteochondrosis in the horse. II. Pathology. | An investigation was made of the pathology of osteochondritis dissecans of young foals and horses with clinical signs of the lesion. A randomly selected material of fetuses and young foals without clinical signs was also examined. It was demonstrated that osteochondritis dissecans is primarily a cartilaginous disease, ... | 233,595 | [
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Effect of parathyroid hormone on plasma prolactin in man. | The iv infusion of parathyroid extract or the synthetic fragments of 1-34 bovine or human parathyroid hormone produced a rapid and marked increase of plasma PRL in normal subjects. The stimulation of the release of endogenous parathyroid hormone by administration of disodium EDTA also resulted in a parallel increase of... | 233,660 | [
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Isolated deficiency of adrenocorticotropin (ACTH) and lipotropins (LPHs). | A patient with hypoadrenocorticism was found to have low basal plasma concentrations of ACTH and lipotropins and deficient responses of these hormones to insulin-induced hypoglycemia and lysine vasopressin. The adequacy of secretion of other anterior pituitary hormones was assessed either directly, by measuring their c... | 233,663 | [
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Altered responsiveness to thyrotropin in thyroid slices of Graves' disease preoperatively treated with excess iodide. | In a previous paper, we demonstrated that the acute administration of excess iodide inhibits the adenylate cyclase-cAMP system in mouse thyroid lobes. In the present study, we examined whether presurgical therapy with stable iodide reduces the responsiveness to TSH in thyroid tissues from patients with Graves' disease.... | 233,671 | [
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0.2843798,
0.3800197,
0.01507273,
-0.1191781,
... |
Overnight plasma profiles of melatonin and certain adenohypophyseal hormones in men. | Melatonin levels exhibited a day-night rhythm with highest levels at night. Nocturnal plasma melatonin concentrations were unrelated to sleep stages, whereas secretion of GH was temporally related to slow wave sleep. Levels of corticotropin rose in the later sleep cycles. We found no relationship between endogenous noc... | 233,675 | [
-0.09450492,
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Cyproteroneacetate and ACTH adrenal function. | Cyproteroneacetate, an antiandrogenic and gonadotropin-inhibiting steroid, has a marked ACTH suppressive effect. In rats, adrenal atrophy and severe impairment of ACTH and corticosterone responses to stress are induced by a 10-day treatment with 3-0.75 mg/100 g BW cyproteroneacetate/day. Two weeks after cessation of tr... | 233,676 | [
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0.1322357,... |
Urinary free 18-hydroxy-11-desoxycorticosterone excretion in normal and hypertensive patients. | One hundred fourteen hypertensives and 20 normal controls were examined using a new clinical technique of measuring 24-h urinary free 18-hydroxy-11-desoxycorticosterone (18-OH-DOC) excretion in response to dietary salt manipulations and ACTH injections. The object was to avoid potential errors of random plasma sampling... | 233,684 | [
-0.3880149,
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... |
Alteration of feedback mechanism of estrogen on gonadotropin by sulpiride-induced hyperprolactinemia. | Four normally cycling women received an iv injection of 20 mg Premarin (conjugated estrogens equivalent to 20 mg estrone sulfate) on the seventh day of two consecutive cycles; the second experiment was performed under sulpiride-induced hyperprolactinemia (mean PRL level = 906 microU MRC standard 71/222 per ml; signific... | 233,689 | [
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0.07512654,
0.1494935... |
The effect of long acting glucocorticoids on menstrual abnormalities in patients with virilizing congenital adrenal hyperplasia. | Amenorrhea or oligomenorrhea occurs in more than 25% of young women with virilizing congenital adrenal hyperplasia due to 21-hydroxylase deficiency who are treated with conventional glucocorticoid therapy. In four such patients, we studied the variation in plasma concentration of ACTH, 17-hydroxyprogesterone (17-OHP), ... | 233,693 | [
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Supersensitivity to norepinephrine or dopamine antagonists after knife cuts that produce aphagia and adipsia in rats. | Aphagia and adipsia of equivalent duration were produced by knife cuts along the lateral border of the hypothalamus (PH cuts), or the medial surface of the globus pallidus (MP cuts) in male albino rats. Striatal dopamine (DA) was reduced by 75% in animals with PH cuts but only 50% by MP cuts. Hypothalamic norepinephrin... | 233,709 | [
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0.02842136,
0.04667224,
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-0.353926... |
Control of beta-glucosidase synthesis in Mucor racemosus. | The beta-glucosidase of Mucor racemosus was shown to be synthesized when the organism was grown in the presence of such diverse carbon sources as glycerol, lactate, xylose, ribose, alpha-methylglucoside, alpha-phenylglucoside, maltose, and cellobiose. Enzyme synthesis was strongly repressed in the presence of hexoses. ... | 233,721 | [
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0.1438315,
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Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element. | A procedure is described that selects for the insertion of transposable antibiotic resistance elements in a variety of recipient replicons. The selected translocation procedure, which employs a plasmid having a temperature-sensitive defect in replication as a donor of transposable genetic elements, was used to investig... | 233,726 | [
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Dominance of dnaA+ to dnaA in Escherichia coli. | The dominance of dnaA+ to the dnaA508 mutation was complete and was unaffected by the presence of a copy of the chromosomal replication origin on the episome. These results prove that the dnaA gene of Escherichia coli produces a diffusible product. | 233,727 | [
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... |
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. | An incidental pregnancy luteoma was identified microscopically in an ovary submitted for ruptured ectopic tubo-ovarian pregnancy. The lesion consisted of a localized, non-encapsulated proliferation of thecal cells in the wall of an atretic follicle and had all the pathologic features of the typical late pregnancy luteo... | 233,743 | [
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Topographical localization of the receptors for luteinizing hormone-releasing hormone on the surface of dissociated pituitary cells. | A derivative of the hypothalamic peptide luteinizing hormone-releasing hormone (LHRH) has been coupled to ferritin and the conjugate purified by gel chromatography. In its ability to stimulate the secretion of luteinizing hormone from pituitary cells in vitro, the conjugate has the same potency and specificity as the n... | 233,747 | [
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0.1751037,
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0.2490452,
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Is there a role for actin in virus budding? | Electrophoretic data from both sodium dodecyl sulfate-polyacrylamide gels (SDS-PAGE) and acid-urea gels reveal a protein in purified murine mammary tumor virus (MuMTV) which co-migrates with purified chick skeletal muscle actin. 125I-labeling of intact and disrupted virus preparations shows that the actin-like protein ... | 233,748 | [
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0... |
Labile (borderline) hypertension--new aspects of a common disorder. | Labile hypertension in patients under 50 years of age (the non-atherosclerotic form) was found to be characterized by higher urinary excretion of catecholamines and particularly of homovanillic acid; when further analyzed it was shown to be a heterogeneous entity with two types of patients clinically and biochemically ... | 233,754 | [
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0.3554224,
0.183645,
0.1136534,
-0.04766... |
Aggregation of sponge cells. XIV. Possible substitution of calcium ions by polycations. | Single cells from the siliceous sponge Geodia cydonium, obtained after chemical dissociation, reaggregate in the presence of the aggregation factor in Ca2+-containing medium to large aggregates. It was found that polyvalent organic cations (polylysine, spermine, spermidine, putrescine) enhance the Ca2+-mediated cell ag... | 233,770 | [
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0.... |
Cyclic nucleotides in nervous tissue. | A review of the literature emphasizes that cyclic nucleotides play a key role in regulation of cell growth, differentiation and metabolism in diverse tissues and, in addition, are closely involved in neural tissue function. The role of cAMP as a second messenger is discussed. | 233,772 | [
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... |
Bovine adenoviruses--IV. Two mixed antigens for routine serodiagnosis by complement fixation reaction. | The frequency of bovine adenovirus infections occurring in cattle has been grossly underestimated up to the present day. Primary isolation of serotypes belonging to bovine subgroup II is cumbersome. Hardly any laboratory has used all 8 officially-recognised bovine serotypes in seroneutralisation-tests, which should be ... | 233,782 | [
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0.1022699,
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Seasonal variations in the renal cortical (Na+ + K+)-ATPase and Mg2+-ATPase of a hibernator, the ground squirrel (Spermophilus richardsonii). | 1. The specific activity of renal cortical (Na+ + K+)-ATPase of the Richardson ground squirrel is markedly reduced during hibernation, in contrast to the specific activity of the accompanying Mg2+-ATPase which is markedly increased. 2. The sensitivity of (Na+ + K+)-ATPase to inhibition by ouabain is unchanged by hibern... | 233,796 | [
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... |
Red cell uridine monophosphate kinase: a comparative study in various vertebrate species. | 1. Starch gel electrophoretic patterns and activity of red cell UMP-kinase were compared in different species of vertebrates. 2. A characteristic electrophoretic pattern for each species of animal studied was found. 3. The mammals differed markedly from the rest of the vertebrate compared in having a faster electrophor... | 233,804 | [
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Levels of true thymidine kinase and nucleoside phosphotransferase in two strains of Tetrahymena pyriformis under different growth conditions. | Activities of typical thymidine kinase and nucleoside phosphotransferase are both present in logarithmically growing tetrahymena pyriformis, GL-1 and ST strains, contrary to previous reports. 2. Activities of thymidine kinase and nucleoside phosphotransferase are also found in both GL-1 and ST strains grown in the defi... | 233,810 | [
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0.3778745,
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Seroepidemiology of human papovaviruses. Discovery of virgin populations and some unusual patterns of antibody prevalence among remote peoples of the world. | A total of 1544 sera from 28 diverse and mainly isolated populations were examined for HI antibody to BK virus. A few extremely isolated populations were found with negligible or absent exposure to the virus, but in most populations, remote or cosmopolitan, antibody appeared in increasing prevalence during early childh... | 233,851 | [
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The treatment of orbital rhabdomyosarcoma with irradiation and chemotherapy. | Fifty-eight patients with orbital rhabdomyosarcoma were treated with irradiation alone (25) or irradiation and chemotherapy (33) with follow-ups of 6 months to 14 years (mean 5.2 yr). At present, 74% are alive and 26% have died. Local control of the tumor was accomplished in 91% of cases. When local sinuses were invade... | 233,865 | [
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0.2447703,
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0.039120... |
Relative irritancy of free fatty acids of different chain length. | Free fatty acids of human skin surface lipids have previously been implicated in the pathogenesis of acne vulgaris because of their apparent irritant and comedogenic properties. Prior studies on the relative irritancy of free fatty acids revealed the saturated C8 to C14 fatty acids and a C18 dienoic unsaturated fatty a... | 233,889 | [
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0.061... |
Cinnamic aldehyde in toothpaste. 1. Clinical aspects and patch tests. | Although cinnamon is known to cause dermatitis in bakers and confectioners, it has only rarely been reported as causing trouble in food or cosmetics. A newly-formulated 'spicy' toothpaste containing cinnamon as a flavouring agent was the cause of oral symptoms in eight patients referred to clinics in Buckinghamshire an... | 233,890 | [
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Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro. | A sensitive procedure employing limiting dilution of activated lymphocytes and 51Cr release from highly labeled target cells was used to derive minimal estimates of the absolute frequency of cytotoxic T lymphocytes (CTL) present in a population of mouse lymphocytes activated to alloantigens of the major histocompatibil... | 233,898 | [
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0... |
Transplacental influence of the thymus. | Peripheral blood lymphocyte levels attained in adult rats that had been thymectomized at birth were markedly reduced if the two or three immediately preceding generations of rats from which they were bred had been thymectomized as neonates. The capacity of thymectomized animals to survive to adult life was also drastic... | 233,916 | [
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... |
Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatibility complex. | Cytotoxic T cells specific for Sendai virus were generated by culturing murine spleen cells in vitro together with UV-inactivated Sendai virus. In vivo immunization of donor mice with UV-inactivated Sendai virus resulted in an in vitro secondary response of increased magnitude. Cytotoxic activity was demonstrated in a ... | 233,918 | [
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... |
Some unusual cases of apexification subsequent to trauma. | Three cases are reported in which apexification occurred without the benefit of endodontic treatment. These reports illustrate that immature teeth which are avulsed and replanted, dislocated and repositioned, or traumatized with pulp necrosis supervening, may progress to form complete apices without intracanal therapy.... | 234,007 | [
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Successful orthotopic allotransplantation of hearts from dogs in irreversible shock. | The viability of the heart from irreversibly shocked dogs was evaluated. Thirty-one mongrel dogs were used to develop a uniformly lethal hemorrhagic shock model. The final model utilized a 30 mm. Hg mean arterial pressure with a 40 percent decompensation (uptake of reservoir blood). All control dogs subjected to this p... | 234,010 | [
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0.08328631,
0.04232135,
0.3722625,
0.006493536,
0.04197508,
0.1444985,
0.006887532,... |
Oxidizing action of purine N-oxide esters. | A technique involving O-acetylation of purine N-oxide derivatives in buffered aqueous solutions has permitted studies of the reactivity of many compounds for which the O-acetyl derivatives are not otherwise available. The oxidizing properties of a variety of N-acetoxypurines have been measured through their ability to ... | 234,029 | [
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... |
Characterization of the ATP-phosphohydrolase activity of bovine spermatozoa flagellar extracts. | The ATP-phosphohydrolase activity of extracts prepared from bovine spermatozoa flagella (BSFE), was characterized with respect to enzyme, substrate, activator ion and salt concentration, temperature dependence and time stability. BSFE required the presence of a divalent cation for activity: Mg++ or Ca++ could function ... | 234,127 | [
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0... |
The syndrome of systemic carnitine deficiency. Clinical, morphologic, biochemical, and pathophysiologic features. | An 11-year old boy had had recurrent episodes of hepatic and cerebral dysfunction and underdeveloped musculature. Overt weakness developed at age 10. Lipid excess, especially in type I fibers, was found in muscle. Hypertrophied smooth endoplasmic reticulum and excessive microbodies were present in liver. Marked carniti... | 234,182 | [
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-... |
The phospholipase activity of sheep pancreatic juice. | Sheep pancreatic juice was found to contain at least two enzymes which hydrolysed biliary lecithin. One enzyme was heat and acid labile and hydrolysed the fatty acid from position 1 (phospholipase A1); the other was heat and acid stable hydrolysing the fatty acid at position 2 (phospholipase A2). Lysophospholipase acti... | 234,191 | [
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0.... |
A comprehensive gas chromatography procedure for measurement of drugs in biological materials. | Procedures have been developed for the determination in serum and urine of 21 drugs which include all of the barbiturates, methyprylon, glutethimide, meprobamate, propoxyphene, methaqualone, primidone, diphenylhydantoin, methadone, codeine, morphine, amphetamine and methamphetamine. The method involves pipeting 1.0 ml ... | 234,218 | [
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Cctionic selectivity of bimolecular membranes in the presence of nystatin and amphotericin B. | Ergosterin or 7-dehydrocholesterin-containing artificial membranes are selectively permeable for cations of alkaline metals in aqueous solutions of nistatin and amphotericine B. Membrane permeability changes spontaneously within several tens of minutes from the cation to the anion one. A decrease of temperature, an inc... | 234,257 | [
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0.05604756,
0.1234007,... |
Experimental salicylate intoxication in young baboons. A preliminary report. | Salicylate intoxication has been investigated in young baboons. The results of these studies are similar to these previously obtained in man. Acidosis appears to be of considerable importance in the pathogenesis of infantile salicylism as it enhances the passage of salicylate into the CSF. The CSF concentration of sali... | 234,262 | [
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0.4179983,
0.3091505,
0.0402116,
0.04999245,... |
Determination of serum thyroxine after dissociation from thyroxine-binding globulin in alkaline solution and absorption on dextran-coated charcoal. | A competitive protein-binding procedure for determining serum thyroxine is described in which thyroxine is described in which thyroxine is first dissociated from serum thyroxine-binding globulins in an alkaline solution. After binding equilibration, the unbound thyroxine is separated by dextran-coated charcoal. The pro... | 234,304 | [
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0.2623211,
0.06812876,
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... |
Evidence supporting a proposed mechanism explaining the inverse relationship between guanidinoacetate and guanidinosuccinate in human urine. | A proposed mechanism [Clin. Chem. 19, 668 (1973)] for the inverse relationship between guanidinoacetate (I) and guanidinosuccinate (II) in human urine is explored. The mechanism proposes that canavaninosuccinate (III) may be reduced to form homoserine and II or, alternatively, that the III may be acted upon by a lyase ... | 234,305 | [
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0.1721885,
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0.6389644,
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0.7419394,
-0.0584924,
... |
[The purity of commercial insulin preparations]. | Insulin preparations available in Germany were tested by polyacrylamide-disc electrophoresis. A large proportion of preparations contained proteins additional to insulin. Insulin purified chromatographically was cleaner than that by crystallization. Insulin purified by ion-exchange chromatography had the highest degree... | 234,378 | [
-0.2129941,
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0.2515009,
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Patterns of LH and FSH release from perifused rat pituitaries in response to infusions of hypothalamic extract. | A continuous flow incubation (perufusion) system was developed in which the secretory responses of pools of hemipituitaries from adult male rats to hypothalamic extract (HE) were characterized by serial radioimmunoassay of LH and FSH in the effluent medium. There was in initial massive release of LH and FSH which, in t... | 234,379 | [
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0.1767364,
0.1909542,
0.185224,
0.08821367,
... |
Pathway from progesterone to 5alpha-reduced c19 steroids not involving androstenedione and testosterone in immature mouse testes in vitro. | Testicular homogenates from mice of 23 and 70 days of age were incubated for 3-120 min with either 3-H-progesterone, 14-C-progesterone, 3-H-5alpha-pregnane-3,20-dione or 14-C-progesterone plus 3H-5alpha-pregnane-3,20-dione in the presence of NADPH. After incubation, radioactive products were purified and identified by ... | 234,383 | [
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0.3443314,
0.5043512,
0.5271545,
-0.1950279... |
The effect of intraocular ablation of the pecten oculi of the chicken. | The pecten oculi of 20 chickens was unilaterally ablated by intraocular electrocautery. Although the pecten was totally destroyed in 13 of the 20 birds, the retina remained histologically normal. All of the birds sustaining total lesion of the pecten retained the pupillary reflex and could peck up food and avoid object... | 234,412 | [
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0.1174718,
0.1425686,
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... |
Stability studies with amphotericin B and amphotericin B methyl ester. | In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methy ester salts. However, when pH is adjusted to 6.0 and storage... | 234,414 | [
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0.1996763,
0.3551791,
0.04010881,
-0.090931... |
Isolation of super-repressor mutants in the histidine utilization system of Salmonella typhimurium. | Two super-repressor mutations in the histidine utilization (hut) operons of Salmonella typhimurium are described. Cells bearing either of these mutations have levels of hut enzymes that do not increase above the uninduced levels when growth is in the presence of either histidine or the gratuitous inducer imidazole prop... | 234,417 | [
0.1277363,
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0.2641142,
0.2975054,
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Changes in composition, biosynthesis, and physical state of membrane lipids occurring upon aging of Mycoplasma hominis cultures. | During the progression of Mycoplasma hominis cultures from the early logarithmic phase to the stationary phase of growth, the total phospholipid content of the cell membranes decreased. Measurement of the amount of the various phospholipids during the growth cycle showed that a decrease in the phosphatidylglycerol (PG)... | 234,420 | [
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0.2040488,
0.5438897,
0.2358913,
-0.1613092... |
Metabolism of prostaglandins E, A, and C in serum. | Three prostaglandin-metabolizing enzymes were detected in human serum. One enzyme was a dehydrase that converted prostaglandin E to prostaglandin A, the second was a prostaglandin A isomerase that converted prostaglandin A to prostaglandin C and the third was a prostaglandin C isomerase that converted prostaglandin C t... | 234,423 | [
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0.4386909,
0.07560448,
0.3229309,
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... |
Purification and characterization of two cellulases from auxin-treated pea epicotyls. | Two forms of beta-1,4-glucan 4-glucanohydrolase (EC 3.2.1.4) were extracted from growing regions of Pisum sativum epicotyls which had been treated with the auxin, (2,4-dichlorophenoxy)acetic acid. One cellulase is buffer-soluble, the other buffer-insoluble but extractable with high salt concentrations. Both enzymes cat... | 234,438 | [
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0.3380527,
0.09355392,
0.4812822,
-0.3... |
Lipids of bovine adrenal plasma membranes. | The lipid composition of a membrane fraction from bovine adrenal cortex was determined. This preparation has the capacity to bind adrenocorticotropic hormone and is enriched in adenylate cyclase and 5'-nucleotidase. The adrenal plasma membranes have a significantly higher lipid content (54.8%) than bovine liver plasma ... | 234,448 | [
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0.2163649,
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... |
The polyadenylate polymerases from yeast. | Poly(A) polymerase activity was first detected in yeast extracts, primarily in association with the ribosomal fraction, by Twu and Bretthauer in 1971 (Twu, J. S., and Bretthauer, RK. (1971) Biochemistry 10, 1576-1582). This activity has now been separated into three distinct enzymes by chromatography on DEAE-cellulose.... | 234,467 | [
0.0197241,
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0.05148704,
0.7370182,
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0.... |
Rat-mouse radiation chimeras: characterization of an antibody-mediated graft-vs-host reaction. | A modification of the Jerne hemolysis-in-agar technique was used to demonstrate antibody-mediated graft-vs-host (GvH) hemolytic activity in lymphoid tissues of rat-mouse radiation chimeras. Initial foci of hemolytic activity were detected on the 3rd day in spleens of lethally x-irradiated mice infused with rat spleen c... | 234,495 | [
0.1200337,
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0.4022757,
0.3361912,
0.4516437,
0.227784,
-0.0974... |
Use of 6-hydroxydopamine to create lesions in catecholamine neurons in rats. | The authors report experiments in rats with 6-hydroxydopamine (6-OHDA), a chemical agent used for creating lesions in catecholamine neurons. Stereotaxic injection of 6-OHDA into the compact zone of the substantia nigra induced degeneration of the nigrostriatal dopamine (DA) system, confirmed by histology and histochemi... | 234,524 | [
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0.1482123,
0.1963013,
0.1050156,
... |
Steroid effect on the brain scan in a patient with cerebral metastases. | A case of cerebral metastases is presented in which the initial brain scan did not demonstrate the lesion because steroid medication had been started 18 hr earlier. The lesion was seen after the patient had been off medication for several days. Therefore, brain scans should be performed prior to starting or following t... | 234,527 | [
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0.1206672,
0.2426585,
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... |
Dental health status of third grade children and their families within the context of a community's dental health care system. | Utilizing structure, process, and outcomes as conceptual dimensions of appraisal of quality, data were analyzed to present an evaluation of the quality of a community's dental health care system as reflected in a population subgroups' dental health status. Data were collected from 838 Caucasian third-graders and their ... | 234,557 | [
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0.3... |
Glycosidases in human skin fibroblast cultures. Alpha-fucosidase, alpha-galactosidase, alpha-glucosidase, beta-mannosidase, and N-acetyl-alpha-glucosaminidase. | Five glycosidases, alpha-fucosidase, alpha-galactosidase, alpha-glucosidase, beta-mannosidase and N-acetyl-alpha-glucosaminidase were studied in human skin fibroblast cultures. The pH-dependency, kinetic properties of the enzymes and results of isoelectric focusing and ion exchange chromatography are presented. Techniq... | 234,663 | [
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0.4880868,
0.1329671,
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... |
Lumbar epidural analgesia with bupivacaine in labor. Determination of drug concentration and pH in fetal scalp blood, and continuous fetal heart rate monitoring. | Lumbar epiduval analgesia with bupivacaine was given to 37 women for uncomplicated labor. After the blcokade serial determinations of pH and bupivacaine concentration were made in fetal scalp blood and maternal venous blood and there was continuous monitoring of the fetal heart rate. Fetal scalp blood pH was within nor... | 234,684 | [
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0.01291217,
-... |
Renal clearance and excretion of endogenous substances in the small pony. | Renal clearance and excretion of endogenous substances were studied in 13 small adult ponies (152 plus or minus 93 (standard deviation (SD)) kg). Normal data of serum and urinary concentrations, clearance, and excretion of creatinine, osmolality, free water, sodium, potassium, and chloride during a 12-hour period are p... | 234,701 | [
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0.3293881,
0.1569233,
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0.004678609,
0.2711035,
0.1890547,
-0.2006562,
0.1081348,
-0.3766529,
-0... |
Cytomegalovirus pneumonia after human marrow transplantation. | Thirty-three of 85 patients undergoing marrow transplantation between 1969 and 1973 developed interstitial pneumonia; 23 died. The clinical syndrome consisted of tachypnea, cough, fever, rales, and hypoxemia; the radiologic findings were variable. The development of interstitial pneumonia was significantly associated w... | 234,706 | [
0.06714807,
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0.2766146,
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Continuous monitoring of pH and Eh in bacterial plaque grown on a tooth in an artificial mouth. | Apparatus which enables the simultaneous continuous monitoring of pH and Eh of bacterial dental plaque as it develops on a tooth surface in an artificial mouth is described. Details of the electrodes used, monitoring equipment, and culture conditions are given. Preliminary results are given showing the Eh and pH valu... | 234,712 | [
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... |
Adsorption of Vibrio parahaemolyticus onto chitin and copepods. | Vibrio parahaemolyticus was observed to adsorb onto chitin particles and copepods. The efficiency of adsorption was found to be dependent on pH and on the concentration of NaC1 and other ions found in seawater. Highest efficiency was observed in water samples collected from Chesapeake Bay and lowest in water from the... | 234,715 | [
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Postmortem changes in brain catecholamine enzymes. | Postmortem changes in the activities of tyrosine hydroxylase, dopa decarboxylase, and dopamine-beta-hydroxylase were examined in various areas of rat brain. Tyrosine hydroxylase activity decreased in an exponential fashion with a half-time of two to four hours in caudate-putamen, substantia nigra, and locus ceruleus. D... | 234,734 | [
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... |
The cerebral ventricles as the avenue for the dipsogenic action of intracranial angiotensin. | Using low doses of angiotensin II (1-128 ng), a mapping study was carried out to redefine the region within the brain from which the dipsogenic response can be elicited. The most sensitive sites were either close to the anterior cerebral ventricles or were at the tips of cannulae that traversed a ventricular space en r... | 234,776 | [
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0.1287017,
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Membrane mutations and production of enterotoxin B and alpha hemolysin in Staphylococcus aureus. | Staphylococcus aureus strain S-6, which produces enterotoxin type B (SEB), and strain 10-275, a high toxin-producing mutant derived from S-6, display pronounced differences in dye sensitivity, osmotic stability, and bacitracin sensitivity. Such characteristics are consistent with the concept that strain 10-275 is a mem... | 234,783 | [
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0.3875878,
0.4111753,
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A renin inhibitor from rabbit kidney: conversion of a large inactive renin to a smaller active enzyme. | Renin in extracts of frozen rabbit kidney exists in two forms: active (molecular weight about 37,000) and inactive (molecular weight about 55,000) renin. The inactive form becomes active after exposure to pH 2.5 at 4 degrees C. If extracts are chromatographed on DEAE cellulose, the inactive renin dissociates into activ... | 234,808 | [
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0.2362752,
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0.2... |
Determination of serum copper by atomic absorption, with use of the graphite cuvette. | We have established and evaluated a flameless graphite cuvette method for copper in serum. This atomic absorption method provides substantial improvement in sensitivity, adequate accuracy, and acceptable precision, and little sample preparation is required before the analysis. Standard addition studies and measuremen... | 234,818 | [
-0.2163501,
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0.02317341,
0.4131794,
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0.05111367,
... |
Oxisuran metabolism in the monkey. | Oxisuran metabolism was studied in the Rhesus monkey in order to assess the suitability of this species as an immunological model for man. The biotransformation pathways observed in the monkey are the same as those seen in rats and dogs. These pathways include the oxidation of oxisuran to a sulfone not found in human p... | 234,829 | [
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0.22872,
0.1142684,
0.1026048,
0.07541631,
0.3500731,
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-... |
In vitro studies on irreversible binding of halothane metabolite to microsomes. | Incubation of rat liver microsomal suspensions with [14C] halothane resulted in the binding of a metabolite of halothane to microsomal phospholipids and, to a lesser extent, to microsomal proteins. The binding was inhibited by carbon monoxide, required NADPH, and was greatly enhanced under anaerobic conditions. The bin... | 234,835 | [
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0.2052105,
0.3057352,
-0.003513532,
... |
Electron-microscopic study of a Mycoplasmatales virus, strain MV-Lg-pS2-L 172. | Morphology and adsorption of a globular virus, lysing Acholeplasma laidlawii were studied in ultrathin sections of plaques in a lawn of the host strain. The virus was globular, about 50 to 90 nm in diameter, with a clearly defined membrane, 6.5 to 8 nm thick. A protuberance about 25 to 35 nm long and 12 to 20 nm thick ... | 234,904 | [
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0.02325242,
0.1499885,
0.7477031,
0.2111408,
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Volume, adherence properties, membrane antigens and mitogen responsiveness of rabbit lymphoid cell subpopulations. | Subpopulations of rabbit spleen cells which respond to T and B mitogens, respectively, can be distinguished by sedimentation velocity in the earth's gravitational field. T cell subpopulations which differed in their responsiveness to Con A and to PHA could be identified by differences in adherence properties and by the... | 234,909 | [
0.1870832,
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0.09878407,
0.1532551,
0.4228632,
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... |
Evaluation of clinical disorders of acid-base balance. | An understanding of acid-base disturbances depends on the interpretation of changes in blood pH, P-co-2, and bicarbonate concentration and a comprehension of the physiologic mechanisms that control them. The physiologic relationships between Pco-2 and bicarbonate can be visualized by means of the balance nomogram and ... | 234,929 | [
0.01994466,
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0.3048885,
0.05335869,
0.2281029,
0.1137642,
... |
Polyphosphate levels in nongrowing cells of Saccharomyces mellis as determined by magnesium ion and the phenomenon of "Uberkompensation". | Magnesium ion enhances the maximum amount of polyphosphate that resting phosphate-starved cells of Saccharomyces mellis can store by increasing the length of time the cells will continue assimilating phosphate. The divalent cation has no effect on the rate of formation of polymer. As much as 12 times more polyphosphate... | 234,944 | [
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0.7719195,
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0.1127642,
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Dihydrofolate reductases from the wild type and aminopterin-resistant mutants of Diplococcus pneumoniae. | Dihydrofolate reductase from the wild type and aminopterin-resistant mutants of Diplococcus pneumoniae has been compared. Specific activity, optimum pH, Km, thermal stability, and inhibition by aminopterin are identical for both strains. Aminopterin resistance for such mutants is, therefore, not due to an alteration of... | 234,945 | [
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0.1776839,
0.06943531,
0.1252701,
0.004435799... |
Induction of hepatic tyrosine aminotransferase in vivo by derivatives of cyclic adenosine 3':5'-monophosphate. | A number of 8- and N6-SUBSTITUTED DERIVATIVES OF CYCLIC ADENOSINE 3':5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE, AND AS SUBSTRATES FOR RAT LIVER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE. All of the analogs tested were able to induce the transaminase. The induction by the analogs was shown to be the result of an actual increa... | 234,951 | [
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0.4795432,
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0.0837198,
-0.20638... |
The nonspecific binding of Fe3+ to transferrin in the absence of synergistic anions. | An obligatory role for barbonate (or other synergistic anions) in the specific binding of Fe3+ by transferrin has been a point of controversy for two decades. There are an equal number of confirmatory and negative reports of specific Fe3+-transferrin binary complexes. A criticism of previous studies is the use of only ... | 234,959 | [
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0.3512602,
0.1730535,
0.117483,
-0.02681518,
... |
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