title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Accessibility of sulfhydryl groups to 5,5'-dithiobis-2-nitrobenzoic acid and acid-base properties of bovine and walleye pollock rhodopsin preparations]. | Both the number of exposed SH-groups and the rate of reaction with 5,5'dithiobis-2-nitrobenzoic acid (DTNB) in walleye pollock and bovine rhodopsin depend on a degree of native structure of the preparation to be investigated. The preparations studied can be arranged in the order of increase of these parameters as follo... | 25,681 | [
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Purinergic innervation of the guinea-pig urinary bladder. | 1 A number of criteria for considering adenosine 5'-triphosphate (ATP) as a neurotransmitter in the guinea-pig urinary bladder have been examined. In addition, the effect of tachyphylaxis to ATP on the response to non-adrenergic, non-cholinergic nerve stimulation has been re-examined.2 Quinacrine fluorescence histochem... | 25,686 | [
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A thermodynamic analysis of the amorphous to crystalline calcium phosphate transformation. | A thermodynamic analysis of the precipitation of amorphous calcium phosphate (ACP) and its transformation to crystalline apatite had been made. A nearly constant ion product, over a wide variety of conditions, was obtained for a tricalcium phosphate (TCP)-like phase suggesting that the molecular unit which governs the ... | 25,699 | [
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Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37 degrees C. | We report optimal conditions for assaying highly purified human lactate dehydrogenase isoenzymes with the lactate-to-pyruvate and pyruvate-to-lactate reactions, as they apply to human serum. Interconversion of results between reactions is not practicable. Measurements of lactate dehydrogenase in either reaction directi... | 25,724 | [
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Streptococcus pneumoniae isolates relatively insensitive to penicillin G recovered from patients in Switzerland. | The sensitivity to penicillin G of pneumococci isolated in Switzerland has been determined by the quantitative tube dilution method. 3 out of 100 strains were relatively insensitive to this antibiotic (minimum inhibitory concentration greater than 0.1 microgram/ml), thus confirming observations already made in other co... | 25,749 | [
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[Excretory function of the kidney after denervation and the administration of a beta-blockader]. | Osmotic diuresis (15% mannitol, 4.5 ml/hr) was in duced in anesthetized rats. At the end of each of 10 consecutive 10-min clearance periods the following parameters were determined: diuresis, sodium, chlorine and osmotic excretion, GFR (inulin clearance). The animals were divided into three groups: a) controls, b) with... | 25,791 | [
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Clostridial sepsis after abortion with PGF2alpha and intracervical laminaria tents--a case report. | A case of clostridial endomyometritis and sepsis necessitating total abdominal hysterectomy which occurred 12 hours following abortion induced with intraamniotic administration of prostaglandin F2 alpha and laminaria tent insertion is discussed. Cultures from cervical, blood, and surgical specimens all yielded Clostrid... | 25,807 | [
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The potential reduction of medical complications from induced abortion. | Reducing medical complications resulting from induced abortion by identifying the safest and most appropriate procedures(s) for each gestational age is the purpose of this study. Data on all women who had induced abortions at all hospitals in the State of Hawaii where such procedures were performed between March 11, 19... | 25,810 | [
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A behavioral approach to post-catastrophic illness work phobias. | Two patients developed work phobias following major catastrophic physical illness. A combined approach to addressing their specific fears of returning to premorbid levels of work function utilized deep muscle relaxation, imagery based desensitization, social reinforcement, and shaping techniques. A significant increase... | 25,848 | [
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Identity of proline dehydrogenase and delta1-pyrroline-5-carboxylic acid reductase in Clostridium sporogenes. | Proline dehydrogenase and delta1-pyrroline-5-carboxylic acid (PCA) reductase activities were copurified 60- and 130-fold, respectively, from extracts of Clostridium sporogenes. The primary change in the ratio of activites was the result of a loss of proline dehydrogenase activity during dialysis. Both activities were e... | 25,881 | [
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Purification and characterization of a secondary alcohol dehydrogenase from a pseudomonad. | Growth of Pseudomonas sp. NRRL B3266 in the presence of oleic acid resulted in the induction of two enzymes: oleate hydratase, which produced 10(R)hydroxyoctadecanoate, and hydroxyoctadecanoate dehydrogenase, which catalyzed the oxidized nicotinamide adenine dinucleotide-dependent production of 10-oxooctadecanoate. Thi... | 25,883 | [
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Changes in hepatic levels of tyrosine aminotransferase messenger RNA during induction by hydrocortisone. | Messenger RNA specific for tyrosine aminotransferase was quantitated by microinjection into oocytes of Xenopus laevis. The heterologously translated enzyme was identified by specific immunoprecipitation and found to be identical with authentic aminotransferase by several criteria. The level of functional message presen... | 25,898 | [
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The identification of an octopaminergic neurone and the modulation of a myogenic rhythm in the locust. | An octopaminergic neurone in an insect is demonstrated. This cell (DUMETi) is the dorsal unpaired median neurone which projects to the extensor tibiae muscle of the locust metathoracic leg. Its soma was physiologically identified, isolated and shown to contain about 0.1 pmol of octopamine. Octopamine is about four time... | 25,941 | [
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Intestinal transport of weak electrolytes: Determinants of influx at the luminal surface. | The determinants of weak electrolyte influx into everted segments of rat small intestine have been studied. Preliminary experiments showed that the observed influxes could be described as unidirectional, diffusional fluxes of the nonionized compound uncomplicated by a parallel ionic component. It is shown that the dete... | 25,945 | [
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Chemical and electrochemical oxidation of 7-hydroxychlorpromazine. | The oxidation of 7-hydroxychlorpromazine, a process associated with several side effects of chlorpromazine therapy, was examined in vitro by electrochemistry and rapid-scanning spectrophotometry. At pH 2, the oxidation results in a quantitative yield of 7,8-dioxochlorpromazine, but several intermediates are observable ... | 25,968 | [
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Experience with 425 subfertile male patients. | Subfertility was evaluated in 425 men. Varicocele were diagnosed in 37.4 per cent of these patients and surgical correction of the varicocele in 68 men resulted in a 65 per cent improvement in semen quality. Idiopathic abnormalities were found in 25.4 per cent of the patients. Since the study group was heterogenous set... | 25,971 | [
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[Acidophilic thermotolerant Candida utilis yeast strain obtained by continuous cultivation]. | An acidophilic thermotolerant strain of Candida utilis 1668-3-37 was produced under conditions of continuous cultivation during 128 days. The optimum pH is 3.0-4.5 at 32 degrees C. The strain grows with mumax=0.30 hr(-1) at 37-38 degrees C and the same pH values if dry yeast autolysate (0.05%) is added to the medium. | 26,012 | [
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Transcription in the interbands of Drosophila. | Many interbands of Drosophila contain morphological evidence for transcription. Decondensed band material makes no detectable contribution to certain transcriptionally active interbands. | 26,090 | [
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Labilization of brain lysosomes by trichloroethylene metabolites and peroxide anion in vitro. | Lysosomes were isolated from adult male Wistar rat brain and incubated in vitro with 10 micron trichloroethylene and microsomes or postmicrosomal supernatant with added NADPH. Freezing and incubation with the solvent alone served as controls. The results were compared with the effect of peroxide anion from the xanthine... | 26,109 | [
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Graft-versus-host reactions within the thyroid gland may evoke pari passu autoimmune thyroiditis. | Unilateral, intraorganal injection of parental lymph node cells into thyroid lobes of F1 hybrid rats elicited an intense, local graft-versus-host reaction within the injected lobes containing massive numbers of lymphocytes. Surprisingly, significant mononuclear cell infiltration was also seen within the contralateral (... | 26,130 | [
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Myocardial effects of lithium in vitro. | The myocardial effects of increasing concentrations of ionic lithium were investigated in isolated, spontaneously beating rabbit hearts, which were retrogradely perfused with a modified Krebs-Henseleit solution containing lithium in concentration of 1, 5 or 10 mM. The following functional parameters were continuously r... | 26,164 | [
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Comparison of beta-adrenoceptors mediating vasodilatation in canine subcutaneous adipose tissue and skeletal muscle. | Blood flow changes in response to various drugs in simulataneously autoperfused canine subcutaneous adipose tissue and gracilis muscle were compared to study the vascular beta-adrenoceptors. Compared to isoprenaline the beta 2-selective agonist salbutamol was 4--6 times more potent as a vasodilator in the muscle than i... | 26,166 | [
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Attenuated variants of eastern equine encephalomyelitis virus: pathomorphological, immunofluorescence and virological studies of infection in Syrian hamsters. | A virulent strain of eastern equine encephalomyelitis virus produced in hamsters a lethal infection with severe lesions of nerve cells predominatly in the anterior parts of the brain. Parenchyma necroses occurred in the liver and lymphoid organs. Infectious virus and viral antigen were found in all the organs examined ... | 26,199 | [
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T lymphocytes as an indicator in influenza vaccination, influenza and acute respiratory diseases. | Significant differences in T-lymphocyte counts in the peripheral blood of normal subject and volunteers vaccinated with live and inactivated influenza vaccines as well as patients with influenza and viral acute respiratory diseases (ARD) were demonstrated. A laboratory test using T lymphocytes was proposed for the eval... | 26,203 | [
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Comparative study of virion transcriptase of some influenza virus strains. | The activities, the temperature and pH optima of in vitro functioning and stability upon heating of virion transcriptase of 10 human influenza virus A strains differing in reactogenicity and isolated in different epidemiological situations, and of fowl plague virus (FVP) were compared. As compared with virion transcrip... | 26,210 | [
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[DNA--"rejoining" in lymphycytes of patients with a minifestation of rheumatoid arthritis in older age (author's transl)]. | Relations between the time of manifestation of the disease and the course of the rheumatoid arthritis were found from the clinic frequently. Patients with later first manifestation of rheumatoid arthritis show clear differences against patients with earlier manifestation of the disease at which the late first manifesta... | 26,226 | [
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[Interactions of drugs, used in the treatment of rheumatism in the elderly (author's transl)]. | This paper reviews the possibilities of interactions of drugs, used in the treatment of rheumatism in the elderly. Exspecially glycosides, antikoagulants, diuretics, uricosurics, salicylates, barbiturates and corticosteroides are discussed. | 26,228 | [
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[Further data on the isolation of the aged (authors transl)]. | Author's studies performed on 100 aged persons over sixty revealed the factors which play a role in the decline of the interpersonal connections. From his results, he suggests two forms of the communication-decrease during senessence. One form is a factor of exogen origin, which comes into existence as a result of depr... | 26,248 | [
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0.1247706,
0.1859711,
0.3013111,
0.2059632,
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... |
Influence of methyl xanthine treatment on calcitonin effect. | The presented results clearly demonstrate that theophylline, caffeine and theobromine have a blocking action on calcitonin effect as determined by the elevation of serum calcium level, although different degree of potency was found with each drugs. There is no difference in respect of the serum calcium elevation after ... | 26,253 | [
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[Survived brain infarction in old age - clinical and morphological findings. part I: extracranial stenoses of carotis arteries (author's transl)]. | By clinical and post mortem findings we searched for the risk factors, important for brain infarctions in people of nearly 80 years. We were especially interested in the conditions of the extracranial vessels such as the carotid arteries and the murmurs at this point. The number of arterial stenoses in this region, asc... | 26,254 | [
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[Results concerning the sensitivity of old patients against digitalis (author's transl)]. | It could be demonstrated that there was an age-dependent increase of digitalisintoxications in correlation with digitalisconcentrations in blood. This phenomenon can be explained with the frequently observed underweight in the senium. Some patients older than 70 years showed symptoms of intoxication in spite of a norma... | 26,259 | [
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0... |
[The motor activity as an age parameter of the rat (authors transl)]. | The motor activity as an behavioural parameter provides information about the functional state of the organism as a whole. Therefore it is an important age parameter. The results of activity measurements, however, depend strongly on the method of registration. Using 3 groups of male Sprague-Dawley rats aged 9, 15 and 2... | 26,274 | [
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Characterization of the papain active centre by using two-protonic-state electrophiles as reactivity probes. Evidence for nucleophilic reactivity in the un-interrupted cysteine-25-histidine-159 interactive system. | 1.2,2'-Dipyridyl disulphide (2-Py-S-S-2-Py) and n-propyl 2-pyridyl disulphide (propyl-S-S-2-Py) were used as two-protonic-state reactivity probes to investigate the active centre of papain (EC 3.4.22.2).2. The existence of a striking rate optimum at pH approx. 4 in the reaction of papain not only with the symmetrical p... | 26,335 | [
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0.001028324,
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Purification and properties of a manganese-stimulated deoxyribonuclease produced during sporulation of Bacillus subtilis. | A DNAase (deoxyribonuclease) was isolated from culture supernatants of sporulating Bacillus subtilis 168. The purified enzyme migrated as a single band during polyacrylamide-gel electrophoresis. The enzyme differs from other DNAases of B. subtilis in molecular weight, metal-ion requirement and mode of action. The enzym... | 26,339 | [
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Prevention and treatment of premature labour by drugs: review of controlled clinical trials. | This review sought evidence from 18 controlled clinical trials about the benefits of drugs (hormones, ethanol or beta-sympathomimetic agents) used to prevent premature birth. Of the 16 trials comparing drug with placebo, 13 were judged to be methodologically adequate. In eight trials, drugs were given prophylactically ... | 26,374 | [
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Photosynthetic electron transport and phosphorylation reactions in thylakoid membranes from the blue-green alga Anacystis nidulans. | Thylakoid membranes were prepared from the blue-green alga, Anacystis nidulans with lysozyme treatment and a short period of sonic oscillation. The thylakoid membrane preparation was highly active in the electron transport reactions such as the Hill reactions with ferricyanide and with 2,6-dichlorophenolindophenol, the... | 26,396 | [
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Role of Bohr group salt bridges in cooperativity in hemoglobin. | Possible problems in measuring the first Adair constant, K1, from accurate oxygen equilibrium curves have been investigated. Of these only the presence of small amounts of CO-hemoglobin or hemoglobin dimers had a significant effect. The former can be eliminated by treatment with oxygen, the latter by measuring the conc... | 26,416 | [
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Influence of pH and temperature on behaviour of surfactant from human neonatal lungs. | The surface pressures of human surfactant films were measured under static conditions and under dynamic (expansion-compression) conditions. The results from both methods showed that the maximum surface pressures generated by surfactant films in vitro were strongly dependent on temperature throughout the range 29-41 deg... | 26,432 | [
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Investigation of the role of histamine in antigen-induced bronchoconstriction in the ascaris-hypersensitive dog. | 1 Aerosol administration of ascaris antigen to the airways of ascaris-hypersensitive dogs provoked increases in pulmonary resistance (Rp) and decreases in dynamic lung compliance (Cdyn). These changes in pulmonary mechanics were not inhibited by the histamine H1-receptor antagonists, diphenhydramine or mepyramine. 2 In... | 26,444 | [
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The treatment of frigidity: a comparative study of group and individual desensitization. | Forty patients took part in this study. Twenty patients treated by group desensitization were compared with twenty treated by individual desensitization. Group desensitization appeared the more effective treatment if outcome was measured on the patients' self-rating scale, but the less effective if outcome was measured... | 26,447 | [
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Induction of autolysis in Bacillus subtilis by ochratoxin A. | Ochratoxin A (OTA) added during the exponential growth phase at a concentration higher than 12 microgram/ml caused autolysis of Bacillus subtilis. Optical density of cultures decreased, and at higher concentrations the cultures became sterile. Optimum OTA-induced lysis was about pH 5. At concentrations below 10 microgr... | 26,457 | [
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Prescribing of psychoactive drugs for chronically ill elderly patients. | The prescribing of psychoactive drugs for 1431 chronically ill elderly patients being assessed for long-term institutional or community care was surveyed. Psychoactive drugs had been prescribed for about one quarter of the patients; benzodiazepines were the most frequently prescribed group. Judging from the extensive p... | 26,459 | [
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Changes in small vessel blood content of the rat heart induced by hypercapnic, hyperoxic or asphyxic conditions. | The small vessel blood content (SVBC) of the ventricular walls of the heart of anesthetized closed chest rats was determined using 59FeC13 to label the plasma siderophilin. SVBC was measured breathing air, 100% O2, 5% CO2 in 21% O2 and during asphyxia. The average SVBC could be ranked: air less than 100% O2 less than 5... | 26,467 | [
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... |
Levodopa pharmacokinetics. Alterations after benserazide, a decarboxylase inhibitor. | Plasma levodopa decay curves appeared to be triexponential up to 6 hr after single intravenous injections of levodopa in rats, rabbits, and dogs. After pretreatment of each of these three species with benserazide (Ro-4-4602), a decarboxylase inhibitor, plasma levodopa concentrations declined biexponentially. Administra... | 26,532 | [
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Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Binding studies with the allosteric effector phenylalanine. | The binding of phenylalanine to the allosteric site of chorismate mutase/prephenate dehydratase has been studied by steady-state dialysis. Under most of the experimental conditions examined positive co-operativity was observed for the binding of ligand up to 50% saturation and negative co-operativity above 50% saturati... | 26,562 | [
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... |
Biphasic effect of chlorpromazine on rat paradoxical sleep: a study of dose-related mechanisms. | The experiments reported here investigated the effect of chlorpromazine (CPZ) alone or after inhibition of catecholamine (CA) synthesis on paradoxical sleep (PS) in the rat. The dose--response curve for CPZ was biphasic with enhancement of PS after low doses, and depression of PS after higher doses. In contrast, low do... | 26,579 | [
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0.1711358,
0.04687582... |
Positive chronotropic and inotropic responses to guanosine in the isolated dog atrium. | The effects of guanosine on chronotropism and inotropism in isolated dog atria were studied in spontaneously beating preparations which were suspended in a bath perfused with arterial blood from a carotid artery of a heparinized support dog. Guanosine administered into the cannulated sinus node artery in a dose range o... | 26,581 | [
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[On the acute toxicity of labetalol (AH-5158), a combined alpha-and-beta-adrenoceptor-blocking agent (author's transl)]. | Acute toxicity studies in labetalol were performed using mice, rats and rabbits, An oral administration of labetalol produced an increase in salivary secretion due to local irritation. Death followed convulsions by large doses of labetalol. Pathological examinations suggested that the cause of death by labetalol was ci... | 26,632 | [
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0.3421432,
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Aspartokinase of Streptococcus mutans: purification, properties, and regulation. | Aspartokinase from Streptococcus mutans BHT was purified to homogeneity and characterized. The molecular weight of the native enzyme was estimated to be 242,000 by gel filtration. Cross-linking of aspartokinase with dimethyl suberimidate and polyacrylamide gel electrophoresis of the amidinated enzyme in the presence of... | 26,656 | [
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Purification and properties of the inducible nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Chlorella sorokiniana. | The nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase (NADP-GDH) of Chlorella sorokiniana was purified 260-fold to electrophoretic homogeneity in six steps. Depending on the techniques used, the native enzyme appeared to have a molecular weight of 290,000 or 410,000 and to be composed of five... | 26,661 | [
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0.... |
Mutations that alter the covalent modification of glutamine synthetase in Salmonella typhimurium. | glnD and glnE mutant strains of Salmonella typhimurium lack three of the four activities required for reversible covalent modification of glutamine synthetase (GS; EC 6.3.1.2). The glnD strains, which are unable to deadenylylate GS and therefore accumulate the adenylylated or less active form of the enzyme, were isolat... | 26,663 | [
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0.5251871,
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Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system. | Stimulation of guinea pig granolocytes by digitonin results in superoxide (O-2) generation. A continuous assay shows that there is a lag between the addition of digitonin and the onset of O-2 production. The rate of activation of the O-2 generating system is dependent upon the concentration of digitonin and the tempera... | 26,695 | [
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... |
Relationship between phosphorylation of tyrosine aminotransferase and regulation of its synthesis by cyclic AMP and hormones. | Tyrosine adminotransferase (EC 2.6.1.5) has been found to be phosphorylated in intact rat hepatoma cells in culture. Incorporation of [32p]i into the enzyme is rapid and is exclusively found as phosphoserine. Cycloheximide treatment reduced phosphorylation of the aminotransferase only slightly and in the presence of th... | 26,702 | [
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0.1... |
The mechanism of the hypothermic effect of amantadine in rats and mice. | Amantadine (25--100 mg kg-1, i.p.) given to rats at an ambient temperature of 4 degrees, or mice at 21 degrees, caused a marked fall in rectal temperature. Prior administration of pimozide (1--2 mg kg-1, s.c.) did not block hypothermia due to amantadine in rats or mice; in contrast, hypothermia due to apomorphine (2 mg... | 26,741 | [
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... |
A mammalian muscle with the pharmacological characteristics of slow tonic muscle. | The guinea-pig isolated cremaster muscle gave tetrodotoxin-resistant dose-related contractures with acetylcholine, carbachol and the depolarizing neuromuscular blocking agents. The dose-response curve to suxamethonium in tetrodotoxin 2 X 10(-7)M could be shifted to the right with tubocurarine 10(-6)M. KCl, 0.1M, produc... | 26,743 | [
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0.1465671,
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0.09415212,
0.2631917,
-0.0121285,
0.2196165,... |
On methods of expressing dissolution rate data. | The value of the Weibull, logarithmic-logistic, and logarithmic-normal plots in expressing dissolution rate data is considered for the combinations of zero and first-order release with sink and non-sink conditions, and for actual dissolution rate data of diazepam from tablets in a medium of pH2. | 26,763 | [
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Investigation of possible interactions between substance P and transmitter mechanisms in the substantia nigra and corpus striatum of the rat. | The effect of substnace P (SP) on the uptake and release of radiolabelled dopamine (3H-DA), 5-hydroxytryptamine (3H-5-HT) and y-aminobutyric acid (3H-GABA) was studied in slices of rat substantia nigra and corpus triatum. SP, 10(-9) to 10(-5) m, failed to modify the uptakes of these compounds during incubations (10-90 ... | 26,766 | [
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Rat brain and serum lithium concentrations after acute injections of lithium carbonate and orotate. | Eight hours after intraperitoneal injections of 1.0, 2.0, and 4.0m equiv Li kg-1, the serum and brain lithium concentrations of rats were significantly greater after lithium orotate than after lithium carbonate. While little serum lithium remained at 24 h after injection of 2.0 m equiv kg-1 lithium carbonate, two-third... | 26,768 | [
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Antidotal effects of dimethyl sulphoxide against paracetamol-, bromobenzene-, and thioacetamide-induced hepatotoxicity. | In mice the hepatotoxic effects of paracetamol (0.5-1.0 g kg-1, orally) as evidenced by increased serum enzyme activities of the aminotransferases and sorbitol dehydrogenase were dose-dependently inhibited by simultaneous treatment with dimethyl sulphoxide (DMSO 0,25-1.0 g kg-1, i.p.). DMSO was also active against brom... | 26,770 | [
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Interaction of tricyclic antipsychotic and antidepressant drugs with 1-anilino-8-naphthalenesulfonic acid. | The binding of 1-anilino-8-naphthalenesulfonic acid to selected tricyclic antipsychotic and antidepressant drugs was studied by fluorescence spectroscopy. The acid exhibited an increase in fluorescence intensity accompanied by a hypsochromic shift of the emission lambdamax in the presence of these drugs. These fluoresc... | 26,787 | [
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Beta adrenergic blockade, regional left ventricular blood flow and ST-segment elevation in canine experimental myocardial ischemia. | The effects of dl-propranolol, d-propranolol, dl-pindolol and dl-practolol on regional myocardial blood flow (assessed by means of tracer microspheres) and on ST-segment elevation in ischemic and nonischemic areas of the canine left ventricle have been investigated. dl-Propranolol and dl-pindolol, but not dl-practolol ... | 26,795 | [
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... |
Liberation of cyanide from alpha-aminonitriles relative to amygdalin. | A series of aminoitriles have been synthesized and studied whose nonenzymatic dissociation with release of cyanide may be varied by modest alteration of their molecular structure from that obtained with nonenzymatic dissociation of amygdalin to that obtained from enzymatic dissociation of amygdalin by substantial quant... | 26,797 | [
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A method for the isolation of Bacteroides melaninogenicus from the human mouth. | Isolation procedures involving the direct plating of specimens and the use of selective, non-selective, transport and enrichment media were compared in respect of their value for the recovery of Bacteroides melaninogenicus from the gingival sulcus. A selective medium containing kanamycin and vancomycin enhanced the rec... | 26,805 | [
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0.004584092,
0.2745... |
Intracellular electrolytes in erythrocytes during and after shock: relation to impaired consciousness. | Of 32 patients in shock and catabolic state following shock with impaired consciousness 31 exhibited raised sodium content in their erythrocytes. On the assumption that the erythrocyte membrane acts the same as nerve cell membrane, the hypofunction of erythrocyte membrane may result in impaired consciousness. The hypof... | 26,808 | [
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0.436563... |
Helper-independent transformation by unintegrated Harvey sarcoma virus DNA. | We have studied the unintegrated infectious DNA of Harvey sarcoma virus (Ha-SV) and Moloney leukemia virus (Mo-MuLV). The source of infectious viral DNA was the Hirt supernatant fraction from cells acutely infected with Ha-SV and Mo-MuLV. To obtain a direct quantitative assay for infectious viral DNA, recipient mouse c... | 26,810 | [
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... |
[Hemodynamic effects of antihypertensive drugs]. | The physiopathology of hypertension is not fully understood, though the haemodynamic pictures accompanying the various arterial forms have been established. Clinical employment of antihypertensive drugs should tend to correct these pictures and the extent to which this is true is examined in the light of the latest evi... | 26,893 | [
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The metabolic profile of adult Fasciola hepatica obtained from rafoxanide-treated sheep. | Sheep infected with adult Fasciola hepatica were drenched with rafoxanide. At 4, 8, 16 and 24 h after drenching the sheep were killed and the flukes removed, washed and rapidly frozen in liquid nitrogen. The content of key metabolites in the fermentation pathway were determined and compared with those in control F. hep... | 26,902 | [
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Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. | A partially purified preparation of the heat-stable enterotoxin of Escherichia coli caused a rapid and persistent increase in electric potential difference and short-circuit current when added in vitro to the luminal surface of isolated rabbit ileal mucosa. As little as 1 ng/ml produced an easily detectable response. U... | 26,915 | [
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Androgen concentration and partial characterization of 5alpha reductase in the epididymis of the rhesus monkey. | The 5alpha reductase activity ofthe monkey epididymis was studied. The enzyme was found in particulate subcellular fractions, its distribution closely resembling that of the microsomal marker enzyme NADPH: cytochrome c reductase, suggesting an association of 5alpha reductase with membranes of the endoplasmic reticulum.... | 26,992 | [
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Lack of correlation between splenic and marrow hematopoiesis following irradiation or irradiation and transplantation in mice. | Differences were seen in the relative importance of spleen and marrow in early erythroid regeneration of lethally irradiated mice given spleen or marrow cell transplants compared with that in sublethally irradiated mice with surviving endogenous hematopoietic cells. Radioactive iron uptake was predominantly in the sple... | 26,995 | [
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[Increase in tryptic digestibility of dietary proteins in the stomach]. | The trypsin assailability of food proteins (bread, dried milk and egg powder pastes) subjected for different periods of time to the action of the gastric juice directly in the stomach was studied by taking account of the specific topography of its content. It is shown that foodstuffs proteins can be increasingly assail... | 27,010 | [
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0.02769174,
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Acute and long-term salt depletion and beta-blockade: plasma renin activity response and its relation to blood pressure reduction in long-term treatment. | The changes in plasma renin activity (PRA) during short-term salt depletion (and peroral furosemide on the first day) and after bolus injection of propranolol were compared to the change during long-term treatment with diuretic and with propranolol in 19 patients with benign primary hypertension. A highly significant c... | 27,064 | [
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... |
Granulomatous ileocolitis preceded by three years of pauciarticular arthritis. | The case of a 12-year old male is presented in whom pauciarticular arthritis preceded the clinical onset of granulomatous ileocolitis by three years. Before the onset of gastrointestinal symptoms, the patients' clinical diagnosis was juvenile rheumatoid arthritis. This case stresses the importance of including inflamma... | 27,094 | [
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The influence of maternal psychological stress on the fetus. | The effects of maternal agitation, induced by exposure to bright light, upon fetal well-being were studied in pregnant rhesus monkeys at 139 to 148 days of gestation. Fetuses were classified as "healthy" or "asphyxiated" according to their initial acid-base state. Following variable periods of maternal excitement, a de... | 27,097 | [
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[Contribution to wet and dry weights of mesenchymal and parenchymatous organs of humans and rats during the course of life (author's transl)]. | The wet and dry weights of parenchymatous (lung, heart, liver, kidney) and of mesenchymal organs (aorta, skin, xiphoid cartilage) of humans and rats (both sexes) were investigated during the course of life. Furthermore, these investigations were done on the following rat organs: brain (divided in cerebrum as well as in... | 27,108 | [
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[Measuring nursing needs of older people related to actual nursing time in institutions for the aged (author's transl)]. | A great many of the elderly people are in need of care. In offering services accordingly it is necessary to acquire relevant data. The following article gives results of a study which determined 1) the real amount of given nursing care and 2) the measured amount of nursing needs of these patients. The research was done... | 27,117 | [
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... |
Acid aspiration during laparoscopy. | The prophylactic efficacy of pre-operative antacid administration was shown by comparing the pH and volumes of gastric contents in 50 female patients treated with 10 ml of Mist. Magnesium Trisilicate B.P.C. with that of 50 controls. Routine antacid prophylaxis was advocated for all patients undergoing pelvic laparoscop... | 27,129 | [
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0.06... |
Chloramphenicol resistance in Streptococcus pneumoniae: enzymatic acetylation and possible plasmid linkage. | Clinical isolates of Streptococcus pneumoniae resistant to chloramphenicol were observed in France for the first time in 1973. During a 4-year survey, these strains were found to represent 6% of a total of 564 isolates of S. pneumoniae in a general hospital and to belong to 13 different serotypes. One such strain, refe... | 27,138 | [
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The action of lecithin monolayers on mosquitoes I. General observations. | Monolayers of pure egg-lecithin at maximum equilibrium pressure were tested against eight species of mosquito in the laboratory, Anopheline larvae were prevented from surfacing and died in water of low dissolved oxygen content, but culicine larvae survived. The pupae of all species except Culex p. fatigans were killed.... | 27,146 | [
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An experimental non-invasive animal technique for measuring nasal airway resistance: I. Adrenergic and antihistaminic agents. | A non-invasive technically simple and sensitive method is described for the determination of nasal airway resistance (NAR). Aerosolized saline elicited a +/- 7% change in baseline NAR, duration 2 minutes, whereas aerosolized histamine increased NAR, duration is greater than 30 minutes. Aerosolized phenylephrine, norepi... | 27,153 | [
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Stabilization of human fibroblast interferon purified on concanavalin A-agarose. | Human fibroblast interferon, obtained by chromatography on concanavalin A-agarose, was stable for at least a month in 30--50 per cent ethylene glycol at 4 degrees, --20 degrees, and --70 degrees C. The succinct point of the present finding is that human fibroblast interferon may be stabilized by ethylene glycol alone w... | 27,163 | [
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0.156381,
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Interaction of fluorinated ether anesthetics with artificial membranes. | Fluorine-19 nuclear magnetic resonance spectroscopy is applied to the study of the environment of dipalmitoyl phosphatidylcholine-bound fluorinated ether anesthetics (enflurane, fluoroxene and methoxyflurane) both below and above the lipid gel to liquid crystal phase transition temperature. Line widths and spin-lattice... | 27,214 | [
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0.1447061,
-0.1920168,... |
Sites of direct and indirect halogenation of albumin. | The sites of radiohalogenation in proteins vary with the labeling method and the pH of the labeling reaciton. We have directly halogenated albumin with carrier-free radioiodide by three methods (pH range 2.2--9.3), and with carrier-free radiobromide by the chloroperoxidase method (pH range 2.2--4.6). Albumin was also i... | 27,226 | [
0.003771765,
0.1012029,
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0.1644805,
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0.09249844,
0.0560339,
0.266777,
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0.054012,
0.218492,
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-0.1361392,
0.2672932,
0.1195436,
-0.2836414,
0.128168,
0.0820925,
-0.0034238... |
An evaluation of respiration chain-associated functions during initiation of germination of Bacillus megaterium spores. | In Bacillus megaterium QM B1551, spore germination could be initiated by glucose in the absence of detectable oxygen consumption, ATP synthesis or a pH decrease in the external media, suggesting that none of those reactions were mandatory. In addition, initiation of germination was insensitive to a variety of inhibitor... | 27,232 | [
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0.05426706,
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0.1790127,
-0.2417041,
-0.1749713,
0.8083217,
0.0357512,
0.07683... |
[Effect of pH on the permeability and mechanical properties of intercellular contacts in the small intestinal epithelium]. | It is shown that acid site population controlling ion permeation through cell contacts is localized in the region of tight junction. The isoelectric point of cell surface in the region to tight junction changed from mean pH = 2.37 +/- 0.1 for duodenum to pH =2.80 +/- +/- 0.1 for ileum. The maximum of cell adhesion in ... | 27,238 | [
0.01471199,
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0.03580222,
0.06126806,
0.2906696,
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0.08880093,
0.1283267,
0.3483939,
0.4758639,
0.09690733,
-0.02297636,
... |
[Pharmacology of azidomorphine]. | As revealed, in acute experiments on rabbits, cats, and rats, a new morphine-like synthetic analgesic drug azidomorphine exceeded 20--100-fold the morphine ability to inhibit synaptic transmission in the thalamic structures, cerebral cortex, and the spinal cord during the nociceptive stimulation, and also by its analge... | 27,263 | [
0.01461264,
-0.06479272,
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0.05615142,
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0.1644341,
0.1366313,
0.2056571,
0.3350428,
0.166019,
-0.0213151... |
Factors limiting the rate of termination of the neuromuscular blocking action of fazadinium dibromide. | 1 Reasons for the termination of the neuromuscular blocking action of fazadinium dibromide have been investigated. 2 In the anaesthetized cat, maximum neuromuscular block of tibialis anterior muscle twitches following rapid intravenous injection of fazadinium was obtained as the injection bolus passed through the muscl... | 27,272 | [
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0.1145997,
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0.2272738,
0.08357117,
0.4300689,
0.1505578... |
Enhancement by an antagonist of transmitter release from frog motor nerve terminals. | 1 The effect of Ba2+ on the synchronous release of acetylcholine from frog motor nerve terminals was studied by conventional electrophysiological techniques. 2 When Ca2+ and Ba2+ were the only divalent cations in the bathing fluid, Ba2+ caused a presynaptic reduction in the amplitude of the endplate potential (e.p.p.).... | 27,281 | [
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0.4441986,
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0.1067957,
0.102009,
0.2589874,
0.0286937,
0.08076052,
0.1003511,... |
Guanosine triphosphate catabolism in human and rabbit erythrocytes: role of reductive deamination of guanylate to inosinate. | The reductive deamination of guanylate to inosinate was demonstrable but occurred at low rates in human and rabbit erythrocytes incubated in vitro with or without glucose. However, the process was considerably accelerated in erythrocytes incubated with deoxyglucose. In human erythrocytes incubated with deoxyglucose, de... | 27,292 | [
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0.1870773,
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0.3518156,
0.331324,
0.0397205,... |
The control of pyruvate kinases of Escherichia coli: further studies of the enzyme activated by ribose-5-phosphate. | The pyruvate kinase activated by ribose-5-phosphate from Escherichia coli has been purified to homogeneity, taking advantage of the stabilization of the enzyme by its inhibitor phosphate and by thiol reagents. The native enzyme has a tetrameric quaternary structure which, while prone to dissociation under many conditio... | 27,294 | [
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0.1912178,
0.1074259,
-0.1078214,
... |
Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes. | 2,3-Dihydro-2,3-dihydroxyaflatoxin B1 (dihydrodiol) was formed as a major metabolite in the incubation of aflatoxin B1 with rat and hamster liver microsomes. The yield of the dihydrodiol was maximal at pH 6.5, was reduced nicotinmide adenine dinucleotide phosphate- and cytochrome P-450-dependent, and was increased 2- t... | 27,299 | [
-0.2290353,
0.03769478,
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0.1789873,
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-0.472719,
0.03065731,
0.2153484,
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0.3229786,
0.2003623,
-0.2939439,
... |
Quantitative characteristics of the Feyrter cells and neuroepithelial bodies of the fetal rabbit lung in normoxia and short term chronic hypoxia. | We report here quantitative data on the Feyrter (single) cells (APUD cells) and neuroepithelial bodies (grouped Feyrter cells), in the lungs of rabbit fetuses at 26, 27.5 and 29 days gestational age, during normoxia and short term chronic hypoxia. The apparent number of these cells declines during this period; we sugge... | 27,304 | [
-0.06975151,
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-0.04954192,
0.5333895,
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0.2935406,
0.2885986,
0.01700454,
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-0.1161821,
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-0.3861891,
-0.06412417,
-0.1496653,
0.2445924,
-0.0429023,
0.3634266,
-0.210449... |
Erythrocyte organic phosphates in the anemia of renal failure in childhood. | Erythrocyte 2,3-diphosphoglycerate (2,3-DPG ) and adenosinetriphosphate (ATP) levels were determined in 43 children with chronic renal failure on conservative treatment (CT), and 12 children on regular hemodialysis (HD) immediately before and after a HD session. The results were compared to non-anemic and anemic contro... | 27,366 | [
-0.2394814,
0.3615249,
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0.438299,
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0.3418535,
0.1402428,
0.1681122,
0.2378628,
0.1490799,
-0.3034292,
0.2... |
[Influence of isolanide and trasicor on the content of nicotinamide coenzymes in the myocardium of growing rats in hemic hypoxia]. | Hemic hypoxia was produced in 7,30-day and 3--5-month old (adult) rats through introduction of sodium nitrite (100 mg/kg) with subsequent determination of the nicotinamide co-enzymes content in the myocardium. The effect of combined and separate application of the cardiac glycoside isolanide and beta-adrenoblocking age... | 27,378 | [
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0.08111819,
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0.0002816238,
0.05453072,
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0.2816923,
0.1773458,
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-0.3468739,
-0.04426339,
-0.1703351,
0.2852702,
0.2359584,
0.3027826,
-0.1672805,... |
Relationship between site of peptic ulceration and gastric acid-peptic activity: new evaluation of gastric analysis in patients with acute gastric bleeding and chronic peptic ulcer. | In an attempt to elucidate the etiology of acute gastric bleeding and/or erosion and chronic peptic ulcer, a measurement of gastric juice and mucosal pepsin was carried out in surgically-treated patients. Patients with massive gastric mucosal bleeding in the fundic gland area showed high levels of fundic mucosal pepsin... | 27,412 | [
-0.1236653,
-0.2300515,
-0.2615137,
-0.2488944,
0.1255786,
0.02651029,
0.3411614,
0.3257428,
0.2949992,
0.1402026,
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-0.1408635,
0.2991577,
0.2270032,
-0.03130371,
0.5732696,
-0.07206903,
-0.00843614... |
Food sensitivity in reflux esophagitis. | We examined 66 patients with pain of possible esophageal origin for sensitivity to intraesophageal infusions of coffee, orange juice, spicy tomato drink, or HCl of varying concentrations as an addendum to their acid infusion (Bernstein) tests. Compared to Berstein-negative subjects, acid-sensitive patients were sensiti... | 27,414 | [
-0.1649762,
-0.3426533,
-0.4860702,
0.09080397,
0.02599065,
-0.225301,
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0.0244632,
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0.08022632,
0.39674,
0.3842147,
-0.4368835,
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-0.2405115,
0.2871959,
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0.1035213,
0.07351487,
0.06936164,
0.05700069,
0.... |
[Acid-base equilibrium in the cerebrospinal fluid in diseases of the central nervous parenchyma]. | A number of case studies reveal and dynamic changes of the acid-base balance in the blood and cerebrospinal fluid, such as the increasing decompensation of the metabolic lactate acidosis in the cerebrospinal fluid in lethal cases or the gradual regression in patients who were cured. Individual metabolic cerebrospinal p... | 27,438 | [
0.02901812,
-0.04062952,
0.1935337,
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-0.1180265,
-0.3651921,
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0.03780017,
0.3466267,
0.08188679,
0.1310557,
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0.03277176,
0.1937319,
0.3058545,
0.05335642,
-0.08490459,
-0.0319... |
Unilateral cryptorchidism with compensatory hypertrophy of descended testicle in prepubertal boys. | 5 prepubertal boys with unilateral cryptorchidism and compensatory hypertrophy of the descended testicle, 22 prepubertal boys with unilateral cryptorchidism and without CTH, and 14 prepubertal normal boys were submitted to LH-RH and to HCG tests in order to study the hormonal behaviour in CTH phenomenon before puberty.... | 27,440 | [
-0.1641888,
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0.08476017,
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0.2078094,
0.3340486,
0.3577269,
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-0.1109723,
-0.3985916,
0.334757,
0.03940224,
-0.0466507... |
Cell envelope of Neisseria gonorrhoeae: phospholipase activity and its relationship to autolysis. | The relationship between conditions which permit or inhibit cell lysis and those which promote phospholipid hydrolysis in Neisseria gonorrhoeae was investigated. Suspension of exponential-phase gonococci in buffer in the absence of divalent cations resulted in autolysis but not in phosphlipid hydrolysis. The addition o... | 27,458 | [
-0.2482713,
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0.09936865,
0.3354372,
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0.2057983,
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0.03979083,
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-0.0407541,
-0.3331239,
0.2354179,
0.693801,
0.1038368,
-0.02829041,... |
Red cell oxygen affinity in fetal sheep: role of 2,3-DPG and adult hemoglobin. | Studies were carried out during fetal life in sheep to determine the relationship of 2,3-diphosphoglycerate (DPG), the intracellular red cell and extracellular pH, and the switchover to adult hemoglobin synthesis in regulating the position of the fetal red cell oxygen-affinity curve in utero. Adult hemoglobin first app... | 27,486 | [
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0.03646735,
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0.1007876,
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0.1058754,
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0.1558248,
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-0.3663352,
0.2884562,
0.3067763,
0.07077869,
0.2810632,
0.3874622,
-0.1897779,... |
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