title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Use of fluorescamine-labeled casein as a substrate for assay of proteinases. | Conditions have been investigated for the use of fluorescamine-labeled casein as a substrate for fluorometric assay of proteinases. Fluorescamine-labeled casein can be prepared simply by mixing solutions of casein and fluorescamine at pH 8.0 and used without removal of the excess reagent or its hydrolysis product. The ... | 27,504 | [
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Effects of methylprednisolone on hydrogen ion absorption in the canine stomach. | The effect of methylprednisolone (2 mg/kg per day given parenterally for 3 doses, 2 wk or 12 wk) on the permeability of mammalian gastric mucosa to hydrogen ion (H(+)) was examined with denervated fundic pouches in dogs with antrectomies. Transmucosal electric potential difference (PD) and net fluxes of H(+) and Na(+) ... | 27,530 | [
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Passive transfer by cells of type II collagen-induced arthritis in rats. | To investigate the role of immunologic hypersensitivity to collagen in the causation of type II collagen-induced arthritis in rats, passive transfer experiments were performed. Wistar/Lewis rats used in these experiments were demonstrated to be histocompatible by prolonged skin graft survival and mixed lymphocyte cultu... | 27,533 | [
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The indirect assay for leukocyte migration inhibitory factor (LIF)--standardization and the effect of pH. | In the indirect assay for leukocyte migration inhibitory factor (LIF), lymphokine-rich supernatants were obtained by culture of stimulated lymphocytes and then tested for LIF activity in agarose plates using purified granulocytes as target cells. Studies on the standardization of the conditions under which LIF acts on ... | 27,562 | [
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Neuroleptics related to butaclamol. Synthesis and some psychopharmacological effects of a series of 3-aryl analogues. | The synthesis and some pharmacological effects of 16 3-aryl analogues of butaclamol, a new antipsychotic drug, are described. The animal models were predictive of neuroleptic activity as well as side effects commonly associated with neuroleptic therapy. The results indicate that the 3-substituent plays a critical role ... | 27,637 | [
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[Acetic acid, a catabolite repressor of cholinesterase synthesis by an Arthrobacter simplex culture]. | Acetic acid was found to repress cholinesterase synthesis in the cells of Arthrobacter simplex var. cholinesterasus even at very low concentrations (0.1%). The repression is very stable. It is not eliminated by glucose or an organic acid of the Krebs cycle being added to the medium with acetic acid. The combination of ... | 27,705 | [
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Thiamine deficiency: selective impairment of the cerebellar serotonergic system. | To explore the role of thiamine deficiency in synaptic transmission, the high-affinity uptake and release systems for putative neurotransmitters were studied in synaptosomal preparations isolated from the telencephalon, hypothalamus, and cerebellum of rats made thiamine deficient by diet or pyrithiamine. There was sign... | 27,736 | [
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31P nuclear magnetic resonance studies of bioenergetics and glycolysis in anaerobic Escherichia coli cells. | 31P nuclear magnetic resonance spectra of glycolyzing, anaerobic Escherichia coli cells and their perchloric acid extracts were obtained at 145.7 MHz. Time-dependent intracellular concentrations of nucleoside di- and triphosphates, Pi, and sugar phosphates were measured during glycolysis with 2-min resolution, while in... | 27,785 | [
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[Treatment of pain with psychotropic drugs (author's transl)]. | 30 patients suffering from therapy-resistant chronic pain were divided into three groups according to drive and mood: I. psychomotor inhibition combined with depressive mood, II. agitation and depressive mood, III. agitation combined normal mood. The psychopharmacological treatment of pain showed sufficient results, wh... | 27,829 | [
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Intracellular acid-base state at a variable temperature in air-breathing vertebrates and its representation. | When temperature changes are superimposed on changes in the control variables of acid-base state (PCO2, strong ion difference), the understanding of acid-base changes becomes difficult. A solution has recently been proposed for blood (Malan, 1977); it was based on the assumption that closed system conditions correspond... | 27,849 | [
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Intracellular buffering. | In the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. The determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active pH regulation and by heterogeneity of cytoplasm with respect to betaa, while heterogeneity ... | 27,854 | [
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[Preventive practice in dentistry and its current meaning]. | Improvements in the field of sealants and of adhesive restorations based thereon represent the most important new development in preventive dentistry. Caries prevention by means of better nutritional habits is greatly enhanced by newly developed and marketed sugar-free and tooth sparing products. Statistical mortality ... | 27,863 | [
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The adrenergic mechanism of the haemodynamic effects of massive doses of hydrocortisone in controlled haemorrhagic shock in the dog. | Haemorrhagic shock was induced in anaesthetized dogs by bleeding them into a blood reservoir system. By adjusting the blood level of the reservoir at a certain distance over the heart level the mean arterial blood pressure was kept at 6.7 kPa (50 mmHg). As has been found earlier, massive doses of hydrocortisone (80-560... | 27,935 | [
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Neuromuscular blockade of fazadinium bromide (AH 8165) in renal failure patients. | Fazadinium bromide (AH 8165) is a new non-depolarizing neuromuscular blocking agent with rapid onset of action and intermediate duration of effect. The characteristics of the neuromuscular blockade induced were compared in normal and renal failure patients by monitoring the mechanical responses of thumb adductor muscle... | 27,936 | [
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Quantitative immunoelectrophoresis of human interferon. A new approach to characterization of interferon preparations. | The electroimmunoassay (quantitative "rocket" immunoelectrophoresis) method was adopted for analysis and characterization of interferon preparations. Ammonium sulphate-precipitated anti-interferon globulin also containing unknown antibodies against antigens that contaminate interferon preparations was used in the tests... | 27,974 | [
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Khasan virus, a new ungrouped bunyavirus isolated from Haemaphysalis longicornis ticks in the Primorie region. | Strain LEIV-776P, possessing no haemagglutinating activity was isolated in 1971 in the Primorie region (U.S.S.R.) from Haemaphysalis longicornis Neumann 1091 tick. Complement fixation (CF) tests revealed no antigenic relationship with 24 antigenic groups of arboviruses or 21 ungrouped viruses isolated from ticks. The v... | 27,977 | [
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Butanol extraction of serum and urinary gamma-glutamyltransferase and its application in clinical diagnosis. | Gamma-glutamyltransferase (gamma-GT) activity was measured in serum and urine before and after extraction with n-butanol. Residual gamma-GT activity after extraction of normal serum with butanol was more than 75%, whereas for normal urine the figure was less than 68%. The loss of activity from urine was not affected by... | 28,067 | [
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Changes in liver tyrosine aminotransferase after acute and chronic administration of morphine in the rat. | Acute administration of Morphine (20 mg/kg/s.c.) in the rat results in a rise of liver tyrosine aminotransferase (TAT) expressed as mumoles of p-hydroxyphenylpyruvate/100 mg/h. With chronic administration, a tolerance develops to this enzymatic effect. TAT induction is not evident in pregnant rats, given the narcotic, ... | 28,112 | [
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Glycogenosis type II: the infantile- and late-onset acid maltase deficiency observed in one family. | The concurrence of the infantile and adult form of acid maltase deficiency in one family is presented. The muscle of both cases possesses residual activity. The glycogen amount in the infantile form is increased tremendously, while in the late-onset the amount of glycogen is normal. | 28,188 | [
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Considerations on physiopathological approaches to the treatment of hypertension. | 1. Two main physiopathological approaches to the treatment of hypertension are discussed, the first based on renin profiling and the second on haemodynamic measurements. 2. Reduction in plasma renin activity does not appear to be a clinically important mechanism in the hypotensive effect of beta-adrenergic blockers and... | 28,189 | [
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alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects. | 1. During acute injection of alpha-methyldopa there is a reduction in the blood pressure within a period of a few hours and a modest reduction in the cardiac output, sometimes due to a modest decrease in heart rate. Frequently the total peripheral resistance is decreased. In contrast, acute injection of beta-blockers i... | 28,190 | [
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Urinary dopamine in man and rat: effects of inorganic salts on dopamine excretion. | 1. Plasma and urine free dopamine (3,4-dihydroxyphenethylamine) were measured in six normal male volunteer subjects and the urinary clearance of dopamine was calculated for each subject. 2. The excretion rates for free dopamine in man were greater than could be explained by simple renal clearance. It was concluded that... | 28,196 | [
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Adenylate cyclase of human gastric mucosa. Stimulation of enzyme activity by histamine and catecholamines. | Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, i... | 28,260 | [
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Non-beta islet cell tumor calcification assoicated with Zollinger-Ellison syndrome and multiple endocrine adenomatosis. | The radiographic triad of a calcified pancreatic mass, duodenal ulcers, and nephrocalcinosis should suggest the Zollinger-Ellison syndrome, as part of the multiple endocrine adenomatosis complex. The clinical and radiographic features of the entity are described in this case report. | 28,264 | [
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Homologous and cross-reactive precipitins in anti-pneumococcal sera raised in mules. | Serial bleedings were obtained from two mules during prolonged immunization, one with type XXV the other with type VIII pneumococcal vaccine. IgGa, IgGb, IgGc, IgB, IgG(T) and IgM present among purified Pn anti-XXV and Pn anti-VIII immunoglobulin isolated from various bleedings were identified by use of rabbit anti-equ... | 28,285 | [
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Acetylcholine: a possible neurotransmitter in Setaria cervi. | The total and free acetylcholine (Ach) and cholinesterase (CHE) content of adult Setaria cervi were estimated. The Ach was estimated by bioassay on rectus abdominis muscle of frog and the CHE by measuring the drop in pH following incubation of worm homogenate with Ach chloride. The free and total Ach contents (4.0 +/- ... | 28,290 | [
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Inhibition of allergic reactions by a new antiallergic drug, LC-6 (trans-2,3b,4,5,7,8b,9,10-octahydronaphthol[1,2-c:5,6-c'] dipyrazole). I. Inhibition of the rat reaginic passive cutaneous anaphylaxis. | A new synthetic compound, LC-6, has been shown to inhibit the passive cutaneous anaphylaxis reactions induced in rats by mouse reaginic antibody. In this system, the ED50 was 35 mg/kg body weight of LC-6 administered per os. LC-6 prevented neither histamine skin reactions nor the reactions to histamine and other chemic... | 28,295 | [
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Assessment of long-acting neuroleptics. Methods and problems. | Long-acting neuroleptics, without offering a therapeutic breakthrough in the treatment of schizophrenia, are nevertheless a definite step in the management of patients with this disorder. The adequate assessment of these agents necessitates methodological considerations to ensure first, just and adequate patient select... | 28,300 | [
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-0.04013665,
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0.1776807,
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0.1431947,
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0.05387214,
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0.03113818,
0.030021,
0.2174374,
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0.1196762,
0.135044... |
Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle. | We studied the reactions of human tracheal and bronchial smooth muscle and canine trachealis muscle to adrenergic agonists. Human tissue was obtained from recent autopsies of patients with normal lungs and patients with respiratory disorders, and canine tissue was obtained from animals used in other experiments. The mu... | 28,308 | [
0.01150455,
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A microelectronic pH sensor. | This paper presents preliminary data on a new integrated circuit microelectronic pH sensor. The device is extremely miniaturized by the use of integrated circuit technology, and uses the intrinsic hydrogen ion selective properties of the gate insulator material. In order to make the device compatible with aqueous solut... | 28,314 | [
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0.1235144... |
Reduction in enamel dissolution by liquorice and glycyrrhizinic acid. | Liquorice extracts and confections reduced enamel dissolution in acidic buffers and saliva/glucose incubations by a direct effect on solubility, and by inhibiting the fall in pH on incubation. These actions may be attributed to the solubility-reducing, glycolysis-inhibiting, and buffering properties of glycyrrhizinic a... | 28,339 | [
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... |
Effect of 4.5--year use of xylitol and sorbitol on plaque. | The pH values of xylitol-containing plaque suspensions of persons who habitually used xylitol and sorbitol during 3.2 to 4.5 years did not significantly differ from those observed with suspensions containing no added carbohydrates. Sorbitol produced in 22-hour incubations pH values as low as 3.9 to 5.5. The activity of... | 28,341 | [
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... |
Low molecular weight C1q-precipitins in hypocomplementemic vasculitis-urticaria syndrome: partial purification and characterization as immunoglobulin. | A lupus-like syndrome involving chronic urticaria with cutaneous vasculitis, systemic symptoms, hypocomplementemia with preferential depletion of C1q, and low m.w. (7S) C1q-precipitins has recently been defined. The C1q-precipitin activity (C1q-p) seems to represent a diagnostic marker of the disease, but its chemical ... | 28,369 | [
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0.05... |
Renal regulation of acid-base balance in a freshwater fish (1). | Intra-arterial injection of a fixed acid load caused only a short-lived (less than 2h) disturbance of blood pH but a long lived (2-3 days) elevation of urinary acid excretion in freshwater trout (Salmo gairdneri). The renal response comprised an immediate increase in acid output in the form of titratable acidity minus ... | 28,376 | [
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0.007407137... |
[Disorders of motility of the stomach and pylorus: pathological significance (author's transl)]. | Five different disorders of motility of the pyloric region may be distinguished if direction and velocity of chyme passing through the pylorus are taken into account: 1. Accelerated emptying of food and overacidification of the bulbus duodeni: 2. Bolus emptying of the stomach and rapid increasing hyperosmolarity in the... | 28,457 | [
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[Methods and problems of investigation of psychopharmacological effect illustrated by the comparison of a novel pyridylbenzodiazepine with diazepam (author's transl)]. | Comparison of two compounds being investigated should take into consideration the most comprehensive spectrum of all psychic variables affected. Consequently, besides 15 standardized investigational methods, three open methods, history, observation of behavior and in particular free exploration were used. The investiga... | 28,480 | [
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[Effect of anions on inhibition of lactate dehydrogenase by pyruvate]. | The effect of anions Cl- and I- on structural and kinetic properties of LDH was investigated. It was shown that anions are specific inhibitors of LDH competing with pyruvate in the active ternary complex, LDHNADHpyq. The following dissociation constants for the anions were obtained from inhibition data: 0.4 +/- 0.02 an... | 28,475 | [
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Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. | A quantitative method is described for the measurement of intralysosomal pH in living cells. Fluorescein isothiocyanate-labeled dextran (FD) is endocytized and accumulates in lysosomes where it remains without apparent degradation. The fluorescence spectrum of this compound changes with pH in the range 4-7 and is not s... | 28,524 | [
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... |
Presynaptic modulation of voltage-dependent Ca2+ current: mechanism for behavioral sensitization in Aplysia californica. | Behavioral sensitization of the gill-withdrawal reflex of Aplysia is the result of a prolonged increase in transmitter release from the presynaptic terminals of sensory neurons. Earlier work suggested that this presynaptic facilitation might be mediated by a serotonin-sensitive adenylate cyclase in the sensory neuron t... | 28,527 | [
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0.384432... |
Effect of benzodiazepines on age of vaginal perforation and first estrus in mice. | Female mice which received chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, or nitrazepam prenatally and postnatally had delays in the age of vaginal perforation and first estrus concomitant with reduced postnatal growth. Females exposed prenatally showed no growth deficits, but in four treatments had delaye... | 28,555 | [
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... |
Granulomatous hepatitis associated with salicylazosulfapyridine therapy. | Granulomatous hepatitis has been associated with many conditions, including chronic ulcerative colitis and sulfonamide therapy. We report a patient with ulcerative colitis in whom hepatic granulomatosis was associated with salicylazosulfapyridine (Azulfidine). Sulfonamides should be considered a possible cause of hepat... | 28,568 | [
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0.1044076... |
Utilization of industrial and agricultural by-products for fungal amylase production. | Attempts were made for using industrial and agricultural by-products and wastes as carbon and nitrogen sources in fermentation medium for alpha-amylase production by Aspergillus niger NRRL-337. The original carbon source of the basal medium was replaced by one of the following materials: rice bran, wheat bran, corn bra... | 28,620 | [
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Accuracy and reproducibility of arterial blood-gas and pH measurements. | In 30 patients blood samples were taken from both radial arteries and analysed for PCO2, PO2 and pH. The influence of sampling technique on the accuracy of blood-gas analysis was determined. The 95% confidence limits for PCO2 measurements were +/-0.32 kPa (2.4 mmHg), and for PO2 measurements were +/-1.16 kPa (8.8 mmHg)... | 28,631 | [
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... |
Carbohydrate metabolism in renal failure. | Hyperglycemia and impaired glucose tolerance are well known phenomena occurring in patients with renal failure. In contrast to true diabetic subjects, an elevated ratio of insulin to glucose during the glucose tolerance test is consistently observed indicating a peripheral insulin insensitivity. Among the possible reas... | 28,664 | [
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0.00141240... |
Persistent pulmonary hypertension in the neonate: development of an animal model. | Chronic intrauterine hypoxia was induced in third-trimester lamb fetuses by daily embolization of the maternal side of the placenta with nonradioactive microspheres. After delivery at term, the chronically hypoxic fetuses had significantly increased pulmonary artery pressures when compared to nonhypoxic control measure... | 28,670 | [
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Glutathione depletion following inhalation anesthesia. | Glutathione depletion following inhalation of halogenated anesthetics was investigated as a possible mechanism of toxic reactions associated with anesthesia. Concentrations of reduced glutathione were measured in the blood, liver, lung and kidney of the mouse after anesthesia with enflurane, fluroxene, halothane, isofl... | 28,682 | [
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The neuropharmacological actions of amoxapine. | Amoxapine possesses a broad spectrum of psychotropic actions, including antidepressant and neuroleptic effects in animals. Antidepressant activity is characterized by its ability to inhibit tetrabenazine-induced depression, antagonize reserpine-induced hypothermia and enhance yohimbine lethality. Neuroleptic activity i... | 28,699 | [
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... |
The effect of chronic administration of digitoxin on the activity of the myocardial (Na + K)-ATPase in guinea-pigs. | When guinea-pigs were treated for 24 days with digitoxin 0.3 mg/kg s.c., the activity of the (Na + K)-ATPase of the heart muscle increased by about 30% compared to controls, whereas the enzymes prepared from kidney and brain showed no significant alteration in their activity. In animal species treated with digitoxin fo... | 28,701 | [
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A characterization of the nucleotide uptake of chromaffin granules of bovine adrenal medulla. | Chromaffin granules isolated from bovine adrenal gland were incubated with (3)H-labelled nucleotides and [(14)C]noradrenaline to study the uptake of these substances. [(3)H]ATP, [(3)H]ADP and [(3)H]AMP are taken up by these organelles by the same temperature-dependent mechanism. The apparent K(m) for ATP and ADP is 1.4... | 28,725 | [
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Quantitation of hydrogen ion and potential gradients in gastric plasma membrane vesicles. | The ATP-dependent uptake of H+ by hog gastric parietal cell vesicles was quantitated by using the pH indicator dyes bromcresol green and malachite green, the weak bases, aminopyrine and 9-aminoacridine, and the pH electrode. A K+-dependent H+ uptake was found, with a significant difference between the quantity of H+ di... | 28,748 | [
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Sidedness of inhibition of energy transduction in oxidative phosphorylation in rat liver mitochondria by ethidium bromide. | Ethidium bromide, a new type of inhibitor of energy transduction in oxidative phosphorylation, inhibited ATP synthesis in intact mitochondria but not in submitochondrial particles, the latter being inside-out relative to the membranes of intact mitochondria. Ethidium bromide incorporated inside the submitochondrial par... | 28,755 | [
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Mechanism of generation and regulation of photopotential by bacteriorhodopsin in bimolecular lipid membrane. | Photoelectric properties of bacteriorhodopsin incorporated into a bimolecular lipid membrane were investigated with special regard to the mechanism of photoelectric field generation. It was shown that besides its proton pump and electric generator functions bacteriorhodopsin works as a possible molecular regulator of t... | 28,756 | [
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Zinc stoichiometry in Escherichia coli alkaline phosphatase. Studies by 31P NMR and ion-exchange chromatography. | 31P nuclear magnetic resonance spectra and enzymatic activities are compared for alkaline phosphatase (orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1) species with different zinc contents. The enzyme containing two Zn2+ per protein dimer exists in two forms; one, prepared by dialysis of nativ... | 28,775 | [
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0.05290... |
3-Chloroacetylpyridine adenine dinucleotide phosphate, an alkylating analogue of NADP+. | An alkylating analogue of NADP+ the 3-chloroacetylpyridine adenine dinucleotide phosphate was prepared from 3-diazoacetylpyridine adenine dinucleotide phosphate which was obtained by enzymatic transglucosidation of NADP+. The 3-diazoacetylpyridine adenine dinucleotide phosphate proved to be more unstable when compared ... | 28,788 | [
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... |
Immunological profile in sarcoidosis patients. The in vitro and in vivo effect of thymic humoral factor. | A study was made of the lymphocytes obtained from 25 patients suffering from sarcoidosis as proved by the Kveim-Siltzbach test and/or organ biopsy. The number of T lymphocytes was determined by the E rosette technique and functional activity by a local xenogeneic graft-versus-host reaction (GVHR) as well as skin tests ... | 28,795 | [
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0.3828291,
0.1770384,
... |
The isolation and identification of 2,4-diketones present in human and animal tissues and in urine. | The chemical isolation of 2,3-diketone fraction from hydrolysates of various mammalian tissues has been accomplished by the use of a modified Girard T procedure. This fraction, which constitutes a new lipid class, has been resolved by gas chromatography into a number of homologous 2,4-diketones, ranging in chain length... | 28,820 | [
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Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP-ribosylation) of basic nuclear proteins. | The isolated nuclei of rat pancreas contain an enzyme system that will incorporate 3H-labeled NAD into an acid-insoluble product, which is shown to be poly(ADP-ribose). The enzyme has an optimum pH of 7.8 and the optimum temperature is between 20 and 30 degrees C. Optimum Mg2+ concentration is 8 mM and dithiothreitol a... | 28,822 | [
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... |
Disposition of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin) in beagle dogs and rhesus monkeys. | Following intragastric doses of 14C-oxaprozin to beagle dogs and rhesus monkeys, oxaprozin was rapidly absorbed and was essentially the only drug-related substance in the plasma for at least 24 hr. Recovery of radioactivity in the excreta was 87% in both species, with the fecal route accounting for almost all of the ex... | 28,928 | [
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Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. | The metabolism of hydrocodone was studied in man, rat, guinea pig, rabbit, and dog. Routes of metabolism included O-demethylation, N-dealkylation, and 6-keto-reduction to the corresponding 6-alpha- and 6-beta-hydroxy metabolites, where each metabolic pathway produces an active metabolite. Mean total recovery of drug an... | 28,931 | [
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[The effect of etilefrine and dihydroergotamine on sympathetic nervous system activity when standing up (author's transl)]. | Systolic blood pressure, heart rate and concentrations of adrenaline, noradrenaline and dopamine as well as plasma dopamine-beta-hydroxylase (DBH) were measured in 22 subjects in recumbency and on standing up. Six subjects each had previously been given intravenously dihydroergotamine (0.5 mg) or etilefrine (0.25 mg/mi... | 28,936 | [
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0.280368,
0.02914775,
... |
Characterization of glucuronide metabolites of carbamazepine in human urine by gas chromatography and mass spectrometry. | Glucuronide metabolites of carbamazepine (5 H-dibenz[b,f]azepine-5-carboxamide) were identified in human urine following chromatography on XAD-2 resin, permethylation, and combined gas chromatography and mass spectrometry with an SE-30 capillary column. Eight glucuronide metabolites, previously unidentified in man, wer... | 28,932 | [
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0.007351756,
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[Comparative trials on sultopride and fluanisone]. | A therapeutic trial has been carried out on 50 patients, most of them being hospitalized, in order to compare the characteristics of a new benzamide, Sultopride, to those of a butyrophenone, Fluanisone, for the treatment of important and chronic agitation states. Clinically, they were essentially psychotic states, with... | 28,939 | [
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0.4550014,
0.08128902,
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-0.1201504,... |
Benign hydatidiform mole in Ibadan, Nigeria. | A study was conducted to analyze 61 patients with benign hydatidiform mole (HM) who were admitted to the University College Hospital in Ibadan, Nigeria, during a 5-year period. The hospital incidence of HM was 1:205 pregnancies, and the condition was seen most commonly in young women, probably because early marriage is... | 28,968 | [
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... |
Respiration and oxidative phosphorylation in Treponema pallidum. | Exogenous and endogenously generated reduced pyridine nucleotides caused marked stimulation of O(2) uptake when added to treponemal cell-free extracts, which indicated that terminal electron transport was coupled to the consumption of O(2). Oxidation of reduced nicotinamide adenine dinucleotide (NADH) was shown to corr... | 29,009 | [
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... |
Antibiotics excretion in canine vaginal and urethral secretions. | Trimethroprim, erythromycin, ampicillin, and rosamicin, a new macrolide antibiotic, were administered to dogs by constant intravenous infusion. Their concentrations in plasma, urine, vaginal and urethral secretions, saliva, and tears were determined by bioassay. Trimethoprim, rosamicin, and, to a lower degree, erythrom... | 29,017 | [
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Psychoactive drug interactions. | Interactions can arise from serial or simultaneous administration of 2 or more drugs. Interactions with other medications can enhance or diminish either the clinical usefulness of a drug, or its toxic effects. Interactions can arise from changes in absorption, protein binding, metabolism, excretion or activity at a com... | 29,033 | [
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... |
Membrane bioenergetic parameters in uncoupler-resistant mutants of Bacillus megaterium. | Mutants of Bacillus megaterium displaying malate-driven ATP synthesis resistant to uncouplers of oxidative posphorylation are further characterized. Both the pH gradient and electrical potential generated across the membrane by malate respiration are equally sensitive to uncouplers in the wild type and uncoupler-resist... | 29,041 | [
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-0.083286... |
Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions. | Isolated rat lungs were ventilated with air and perfused with a blood-free Krebs-Ringer bicarbonate solution under conditions of net CO2 elimination in the lung. Some of the effluent perfusate was drawn through a stop-flow pH electrode apparatus, arriving at the electrode within 4 s after passing through the pulmonary ... | 29,055 | [
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Selective defect of precursor T cells associated with apparently normal B lymphocytes in severe combined immunodeficiency disease. | Two patients, one with an autosomal and the other a sex-linked form of severe combined immunodeficiency, had more than 95% B cells in their peripheral blood. Despite an increased absolute number of B lymphocytes, the patients were unable to produce serum antibodies. In each patient, geno- or pheno-identical bone marrow... | 29,085 | [
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... |
The effect of microcapsule size on the oxidative decomposition of core material. | The factors that affect the size of microcapsules and the oxidation of their benzaldehyde core have been examined. The pH of the preparation changed the overall size of the microcapsules which reached a maximum diameter at pH 4.1. The size of the core droplets also varied with the preparative pH and their oxidation rat... | 29,089 | [
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Developmental restrictions on hormone modulated gene transcription. II. Hormone induced interactions of RNA polymerase with chromatin. | Chromatin-bound and soluble RNA polymerase subspecies have been isolated and fractionated by isoelectric focusing at various times (0, 6, 12 and 18 h) following auxin treatment of 4 day (responsive) and 8 day (unresponsive) soybean hypocotyls. Young 4 day seedlings displayed two well defined phases of auxin induced gen... | 29,171 | [
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High pyruvate kinase activity causes low concentration of 2,3-diphosphoglycerate in fetal rabbit red cells. | 1. The high oxygen affinity of fetal blood in rabbits is due to a very low concentration of 2,3-diphosphoglycerate (2,3-DPG) in the red cells. In order to gather informations on the factors responsible for this characteristic we have studied synthesis and break-down of 2,3-DPG in fetal and adult rabbit red cells in vit... | 29,278 | [
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A new putative neuroregulator of the extrapyramidal system. | A putative neurotransmitter, 2-phenylethylamine, which is most highly concentrated in the extrapyramidal system of human brain, is able to reverse reserpine-induced parkinsonism in animals and elicit stereotypy. This action is only partially antagonized after catecholamine depletion by pretreatment with a-methyl-para-t... | 29,315 | [
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0.23959,
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[Neuroleptics and sexual dysfunction in man. Neuroendocrine aspects]. | Sexual behaviour and fertility of schizophrenic patients are discussed. The various sexual dysfunctions induced by neuroleptics, such as decrease in libido, troubles of ejaculation and impotence, are described and related to their various mechanisms of action. The central antidopaminergic effect of neuroleptics would b... | 29,337 | [
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... |
[Acid-base state disorders and their correction in acute mesenteric vascular obstruction]. | The results of the investigation of main indices of acid-base equilibrium in 28 patients with acute obstruction of the mesenteric vessels are set forth. 12 patients out of 28 developed subcompensated or decompensated metabolic acidosis. The authors believe that the correction of acid-base equilibrium disorders is an ef... | 29,372 | [
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In vitro and in vivo studies on Leydig cell function in old rats. | Young adult (3 months old) and old (26-28 months old) male Wistar rats were studied. Testicular weight was 1.66 g (range: 1.33--2.86) in the younger group and 1.62 g (range: 1.04--1.90) in the older group. The total Leydig cell volume as measured by a quantitative histometric method was significantly larger in the old ... | 29,425 | [
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-... |
Studies on calcium uptake by myometrial microsomes with particular reference to the dependence on inorganic phosphate and oxalate. | Ca uptake by microsomes isolated from non-pregnant rabbit myometrium was potentiated by both inorganic phosphate (Pi) and oxalate anions. Both Pi and oxalate had little effect on the initial rate of uptake but a pronounced effect on the capacity of Ca uptake measured after 20 min which was greater in the presence of ox... | 29,440 | [
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A controlled long-term study of flunitrazepam, nitrazepam and placebo, with special regard to withdrawal effects. | The hypnotic effect of flunitrazepam (Ro 5-4200), nitrazepam and a placebo was studied in 117 outpatients using hypnotics for at least 3 months prior to the study. They obtained various neurotropic drugs and this and other treatments were unchanged throughout the trial period of 13 weeks. This consisted of 3 weeks on t... | 29,441 | [
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Interaction between PCO2 and plasma [HCO-3] in regulation of CSF [HCO-3] in respiratory alkalosis and metabolic acidosis. | The results of studies presented may be interpreted in light of the dual contribution theory of regulation of CSF acid-base balance, indicating significant interaction between systemic and local CNS mechanisms in H+ homeostasis in the brain and CSF. Both systemic and local mechanisms are at work in H+ homeostasis in th... | 29,457 | [
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Strain differences in electrophoretic mobility of influenzavirus A polypeptides. | Slab polyacrylamide gel electrophoresis of Influenza-virus A strains varying in antigenic composition of the envelope and in the natural host species showed the nucleprotein and membrane proteins to have a standard molecular weight of 58,000 and 24,000 daltons, respectively. The electrophoretic mobility and molecular w... | 29,472 | [
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Evaluation of the counterimmunoelectrophoretic (CIE) procedure in a clinical laboratory setting. | The counterimmunoelectrophoretic (CIE) procedure was evaluated under clinical laboratory conditions to determine its validity and comparability with culture methods. The procedure was further evaluated to determine applicability to a variety of clinical samples. An inexpensive set-up was developed to utilize the CIE pr... | 29,483 | [
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0.0814521... |
Ammonia metabolism. | The pathways responsible for an the mechanisms underlying the adaptive increase in ammonia production in response to acidosis are considered. It seems unlikely that the cytosolic pathways (glutamine synthetase, glutaminase II, phosphate-independent glutaminase, and gamma-glutamyl transferase) are of primary importance ... | 29,492 | [
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Psychotropic drugs, summer heat and humidity, and hyperpyrexia: a danger restated. | The authors note an apparent unawareness of, as well as a paucity of recent literature pertaining to, hyperpyrexia as a complication of psychotropic drug treatment. They report a case of hyperpyrexia in a patient receiving psychotropic agents during a summer heat wave; massive muscle destruction (rhabdomyolysis) with m... | 29,501 | [
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0.... |
Hydrogen peroxide and superoxide radical formation in anaerobic broth media exposed to atmospheric oxygen. | Fourteen different broth media were autoclaved under anaerobic conditions and then exposed to atmospheric oxygen. The hydrogen peroxide and superoxide radical formation as well as the bactericidal effect of the media were studied. The rate of killing of Peptostreptococcus anaerobius VPI 4330-1 was high in media that ra... | 29,560 | [
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0.05489464,
... |
Establishment of a heat inactivation curve for Clostridium botulinum 62A toxin in beef broth. | A procedure is described for establishing a heat inactivation curve for the toxin of Clostridium botulinum 62A in beef broth. The effect of toxin titer, pH, and the type of acid employed for pH adjustment on the heat stability of the toxin is described. | 29,566 | [
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... |
Utilization of D-amino acids by dadR mutants of Salmonella typhimurium. | Utilization of D-amino acids being substrates of D-amino acid dehydrogenase of Salmonella typhimurium was examined. The experiments were done with wild type strains and the mutants dadA missing the enzyme activity and dadR in which its synthesis is released from catabolite repression. Growth on D-tryptophan, D-histidin... | 29,590 | [
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... |
Critical ionization states in the reaction catalyzed by triosephosphate isomerase. | To allow the detailed interpretation of the pH dependences of the steady-state parameters for the reaction catalyzed by triosephosphate isomerase, three kinds of experiments have been performed. First, the value of kcat/Km for enzyme-catalyzed isomerization of the phosphonate analogue of D-glyceraldehyde 3-phosphate (2... | 29,659 | [
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0.2063088,
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Refolding transition of alpha-chymotrypsin: pH and salt dependence. | It is well known that alpha-chymotrypsin can exist in two major conformational states, only one of which is active. We have examined the pH (pH 2.0--11.0) and salt (ionic strength 0.01--1.0) dependence of the transition between the active and inactive forms in detail. At low pH (pH 2.0--6.0) the equilibrium is very dep... | 29,661 | [
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0.030... |
Estradiol receptor analysis in human breast cancer tissue by isoelectric focusing in polyacrylamide gel. | Isoelectric focusing in polyacrylamide gel combined with limited proteolysis is a simple and specific method for quantitation of estradiol receptors in breast cancer tissue. At least eight different samples can be analyzed simultaneously on one gel, and the whole procedure, including sample preparation, takes less than... | 29,706 | [
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0.0206312... |
[Effects of levophacetoperane, pemoline, fenozolone, and centrophenoxine on catecholamines and serotonin uptake in various parts of the rat brain]. | These drugs, except centrophenoxine, inhibit in vitro in a competitive manner, norepinephrin uptake in Rat hypothalamus and cortex, and dopamine uptake in corpus striatum and cortex, at higher concentrations than d.l. amphetamine; this alone inhibits serotonin uptake in hypothalamus. | 29,714 | [
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Kinetics of the reactions of unconjugated and conjugated bilirubins with p-diazobenzenesulfonic acid. | We report the kinetics of the reactions of unconjugated bilirubin and conjugated bilirubin with p-diazobenzene sulfonic acid in aqueous media. Our studies confirm that each reaction proceeds in two steps and that the second step is catalyzed by sulfanilic acid. In the presence of an excess of p-diazobenzenesulfonic aci... | 29,720 | [
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0.04499279,
0.3403027,
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-0.2036888... |
Lactosyl ceramidosis: deficient activity of neutral beta-galactosidase in liver and cultivated fibroblasts? | Neutral beta-galactosidase was partially purified from liver of normal controls, a patient with Niemann-Pick disease type A and the previously described patient with lactosyl ceramidosis using Concanavalin A-Sepharose adsorption and Sephadex G-100 gel filtration. The partially purified fractions were essentially free o... | 29,729 | [
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0.3091992,
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... |
The influence of dialysis fluid composition on the blood pressure response during dialysis. | To elucidate the relative role of osmolar (sodium) and acetate shifts during dialysis, 6 patients with problems of overhydration underwent rapid ultrafiltration for 1 hr (mean weight reduction 2.0 kg), using the 1 m2 RP 6 dialyzer. Ultrafiltration was carried out at the beginning of each of 5 dialysis treatments at wee... | 29,737 | [
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(-)-2-Hydroxy-n-cyclopropylmethylmorphinan: radioimmunoassay and phamacokinetic profile. | The pharmacokinetic profile of (-)-2-hydroxy-N-cyclopropylmethylmorphinan (HCMM), a narcotic antagonist and analgesic, has been evaluated in man following administration of 25 to 50 mg of the drug orally and 10 to 15 mg intramuscularly. A specific radioimmunoassay procedure was developed for the determination of HCMM i... | 29,740 | [
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0.1317181,
-0.0067252... |
[Scanning electromicroscopic studies of the surface of teeth. I. After manual treatment with tooth cleansers. II. Tooth cleaning with power-driven instruments]. | Scanning electron microscopic examination of tooth surfaces after using manually operated instruments to remove calculus showed distinct lesions on the hard substances of the tooth. The extent of damage depends considerably on the area of the tooth treated (the border between the enamel and the cementum is particularly... | 29,748 | [
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Studies on renal dopamine receptors with a new agonist. | SK & F 38393 (2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine) is a new dopamine receptor agonist which selectively increased renal blood flow when administered i.v. to dogs at cumulative doses of 3.3-1333 microgram/kg. Consistent changes in arterial blood pressure heart rate and cardiac output were not ... | 29,762 | [
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0.3141398,
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... |
Effect of adrenaline and adrenergic active drugs on growth hormone secretion in immature cockerels. | In immature cockerels adrenaline administration lowered the levels of plasma growth hormone. Both alpha and beta adrenergic receptor agonists also depressed the circulating growth hormone levels. In the presence of beta blockade, the suppressive effect of adrenaline on growth hormone secretion was not observed. | 29,771 | [
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Birth interval study in a culturally stable urban population. | Five hundred women were interviewed within 2 days of delivery to examine indigenous birth spacing among the urban and rural population of Ife township. The crude birth interval was between 30 and 40 months due mainly to cultural attitudes towards lactation and sexual abstinence. The women studied possessed considerable... | 29,795 | [
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0.04223... |
Long-term effect of pH on B-cell function in isolated islets of Langerhans in tissue culture. | Collagenase isolated mouse pancreatic islets were maintained in tissue culture for up to 5 months in a culture medium buffered with Hepes and the pH varying between 6.8 and 7.6. The amount of insulin released into the medium and the insulin response to glucose and glucose plus theophylline were measured during the cult... | 29,815 | [
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0.0815131... |
Reproduction and breeding of goats. | Reproduction and genetics of the goat are reviewed with a view of increasing their contribution to mankind. The goat contributes most in tropical regions (within 30 degrees of the equator). The most important product from the goat is milk with meat a close second. Other products are minor. Reproductive rate is a proble... | 29,915 | [
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0.5076671,
0.2351519,
-0.2818782,
0.... |
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