title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. | W3/25 antibody is the monoclonal product of a hybrid cell resulting from the fusion of a mouse myeloma cell line with spleen cells from a mouse immunized with rat thymocytes. Pure clones have been derived, and segregants free of parental myeloma chains have been isolated. Previous studies have shown that this antibody ... | 29,936 | [
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In vivo desensitization to beta receptor mediated bronchodilator drugs in the rat: decreased beta receptor affinity. | When tracheas were isolated from rats pretreated with isoproterenol (ISO) or terbutaline, they were found to be considerably less sensitive to the relaxant action of ISO than tracheas which were isolated from saline-pretreated rats. The dissociation constant (Kb) for the propranolol-beta receptor complex was determined... | 29,962 | [
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Renal bicarbonate reabsorption in the new-born dog. | 1. Renal bicarbonate reabsorption was measured in thirty new-born dogs 2-27 days of age. Plasma bicarbonate was varied in the puppies by exchanging their blood with blood containing high levels of bicarbonate and low levels of chloride.2. The exchange transfusion resulted in increases of plasma pH, P(CO2) and bicarbona... | 29,966 | [
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Glutamine and glutamic acid uptake by rat renal brushborder membrane vesicles. | Glutamine uptake by rat renal brushborder vesicles occurred via two distinct saturable processes with Km values of 0.145 and 8.5 mM which were stimulated by both ionic and sodium gradients with a pH optimum of 6.8--7.1. Glutamic acid uptake also occurred by a two-component system with Km values of 0.016 and 3.60 mM. Bo... | 29,969 | [
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Postperfusion lung syndrome. Comparison of Travenol bubble and membrane oxygenators. | To examine the role of the oxygenator in the postperfusion lung syndrome, we studied 16 patients undergoing aorta-coronary bypass with a bubble oxygenator and 14 similar patients with a membrane oxygenator both before and for 2 days after the operation. To maintain the same pulmonary artery occluded pressure and hemogl... | 29,994 | [
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Kainic acid and synaptic transmission in the stellate ganglion of the squid. | Kainate, a conformational analogue of glutamate, blocks synaptic transmission across the giant synapse of the squid. In the presence of blocking doses of kainate, impulses continue to propagate into the nerve terminal, but action potentials are slightly reduced in size and the subsequent hyperpolarization is greatly di... | 30,092 | [
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Brain catecholamines metabolism in offspring of amphetamine treated rats. | Previous observations have pointed out that treatment with amphetamine during pregnancy produces behavioral modifications in adulthood. In order to elucidate some possible brain biochemical mechanisms that could explain the behavioral changes observed we have determined the endogenous content of brain dopamine and nora... | 30,095 | [
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Effect of alcohol and benzodiazepines on performance as related to personality characteristics. Personality characteristics among healthy "placebo reactors" and nonreactors. | For 2 weeks 40 volunteers received either 5 mg diazepam, t.i.d., or 10 mg chlordiazepoxide, t.i.d., and placebo. A choice reaction test, two coordination tests, and an attention test were administered to the subjects on the 14th day of each treatment. Thirty minutes before the tests, the subjects ingested either alcoho... | 30,099 | [
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Activation of guanylate cyclase by arachidonic acid in mammary gland homogenates from mice. | Arachidonic acid stimulated guanylate cyclase activity about two fold in homogenates of mammary glands obtained from midpregnant mice; effects of arachidonic acid were observed during incubation periods between 5 and 20 minutes. Stimulatory effects of arachidonic acid on guanylate cyclase activity were observed when 10... | 30,119 | [
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Separator isoelectric focusing for identification of alpha-1-antitrypsin (Pi M) subtypes. | A modified analytical isoelectric focusing procedure on polyacrylamide gel slabs, offering increased resolving capacity, has been developed for identification of six subtypes of the most common alpha-1-antitrypsin (A-1-AT) phenotype, Pi M. Combination of commercial Ampholine and other ampoteric substances, so called se... | 30,163 | [
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Effects of beta-adrenergic stimulating and blocking agents on the dynamics of the human bladder outlet. | The alpha-adrenergic innervation of the functional urethra is a well-known fact, while beta-adrenergic influence is rather unknown until now. We studied the influence of beta-stimulating and beta-blocking agents on the human urethra by the urethral pressure profile (UPP). A decrease of the UPP under orciprenaline sulfa... | 30,200 | [
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[The coincidence of visceral lupus erythematosus and epilepsy]. | It is reported on course and problems of the diagnosis of a lupus erythematodes visceralis with epilepsy. In the demonstrated case the initial stage was characterized by the nearly simultaneous appearance of relapsing arthritides and epilepsy. The diagnosis was made in the stage of an acute exacerbation with cardiac sy... | 30,220 | [
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The effect of stannous fluoride on human plaque acidogenicity in situ (Stephan curve). | A system employing an Ingold glass electrode was shown to give reliable measurements of pH drops in dental plaque in situ (Stephan curve readings). The system was used to demonstrate that mouthrinses of 0.2 per cent aqueous solutions of stannous fluoride reduced the pH drops markedly for at least seven hours. A reducti... | 30,252 | [
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Binding of bile acids by dietary fiber. | Binding of bile salts to food residue was studied in vitro and in vivo. In the in vitro experiments, residues of a number of foods were incubated with each of several bile salts at different concentrations and pHs. All food residues tested adsorbed more dihydroxy than trihydroxy bile salts. Bile salt binding increased ... | 30,273 | [
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Inhibition of canine gastric acid secretion by an H-1 receptor antagonist to histamine. | Histamine H-2 receptors are thought to mediate gastric acid secretory responses, whereas H-1 receptors supposedly regulate mucosal vascular responses to histamine. In an in vivo chambered canine stomach flap preparation, the H-1 receptor antagonist, tripelennamine, injected intraarterially (22.1 mumol/kg) into the stom... | 30,277 | [
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[Medical check-ups and selection of subjects: some results from a gerontological field-study (author's transl)]. | In a gerontological field-study in Cologne, West-Germany, 1114 subjects of a random sample of elderlies were successively offered three modalities for a medical check-up, which covered a physical examination and a psychiatric interview: 1. in the out-patient department of a psychiatric hospital (Rheinische Landesklinik... | 30,295 | [
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[Study on the effectiveness of the "Berlin Letters for Seniors (author's transl)]. | The effectiveness of the "Berlin Letters for Seniors" (LFS) will be tested by a longitudinal study. Two Measurement Points (MP) are scheduled: 1976 and 1978. The total sample (N = 3000) comprehends two subsamples of receivers and non-receivers. Data were/will be collected by a questionnaire. A preliminary analysis of t... | 30,297 | [
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[Anesthetic evidence of pheochromocytoma]. | The authors report the clinical case of a patients who underwent four anaesthetic inductions during a period of 3 months. Two were associated with severe acute hypertension making the intended operation impossible at that time. Thorough investigations led to a diagnosis of phaeochromocytoma. Reviewing the protocol of t... | 30,356 | [
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Calcium ion regulation in barnacle muscle fibers and its relation to force development. | It is possible to use the photoproteins aequorin and obelin within the slowly responding striated muscle films to provide both qualitative and quantitive information as to the nature of the calcium-dependent reactions for force development. It seems that these reactions are not in equilibrium with the Ca2+ during a tra... | 30,379 | [
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Influence of aminophylline or beta-adrenoceptor blockade on glucagon release by a vasoactive adenosine analogue. | The glucagon-releasing activity of adenosine-5'-ethyl-carboxamide (744-96) was studied in conscious dogs pretreated either with aminophylline or with bupranolol, a beta-adrenoceptor blocking drug. The adenosine antagonist, aminophylline, inhibited both the glucagon-releasing and the blood pressure lowering effects of 7... | 30,423 | [
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The effect of methylphenidate on serum growth hormone: influence of antipsychotic drugs and diagnosis. | Intravenously administered methylphenidate, 0.5 mg/kg, causes a consistent rise in human serum growth hormone level, with peak values usually occurring 30 minutes after infusion. This rise is attenuated in patients receiving various antipsychotic medications administered on a long-term basis and is decreased in schizop... | 30,430 | [
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Metal chelate affinity chromatography of hamster interferon. | Syrian hamster interferon, produced by benzo(a)pyrene-transformed embryo cells does not display an affinity for Zn++ chelate-agarose. However, the interferon binds to Cu++ chelate-agarose and can be displaced from the column by a falling pH-gradient. The chromatography of crude hamster interferon preparation on a tande... | 30,433 | [
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The effect of bovine serum albumin on partial reactions of palmitoyl-CoA chain elongation by rat liver microsomes. | In the absence of albumin, v/s curves for both condensation and overall chain elongation demonstrated that the specific activity for overall chain elongation was 3.7 times that of condensation. When the molar ratio of palmitoyl-CoA to albumin was greater than 2 : 1, the specific activity of chain elongation exceeded th... | 30,485 | [
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Release of 3H-purines from [3H]-adenine labelled rabbit kidney following sympathetic nerve stimulation, and its inhibition by alpha-adrenoceptor blockage. | 1 Rabbit kidneys were isolated and perfused with Tyrode solution. Release of 3H-purines was studied after labeling of the adenine-nucleotide stores with [3H]adenine (more than 60% uptake during a single passage). 2 One hour after labelling the spontaneous 3H-outflow amounted to 0.1 to 0.2% of the total tissue content p... | 30,505 | [
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Differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: effects of metanephrine and tolazoline. | The alpha-adrenoceptor blocking agent, tolazoline, and the O-methylated metabolite of adrenaline, metanephrine, produced a concentration-dependent increase of tension in the smooth muscle of the cat isolated nictitating membrane. These effects were considered to be due to the activation of postsynaptic alpha-adrenocept... | 30,506 | [
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A presynaptic component of the action of iontophoretically applied flurazepam on feline cortical neurones. | The effect of iontophoretically applied flurazepam on the spike activity of pericruciate cortical neurones of the cat was studied. Flurazepam increased cortical inhibition produced either by local electrical stimulation (which is known to release gamma-aminobutyric acid (GABA) or by iontophoretically applied GABA. Foll... | 30,528 | [
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Chemical characteristics of a high molecular weight renin from the renal cortex of the dog. | We found an acid extract of normal dog kidneys to contain two distinct molecular weight forms of renin-like activity. Gel filtration chromatography showed peaks of activity as estimated molecular weights of 65,000 and 41,000. The high molecular weight fraction (HMW) comprised only 1% of the total activity of the extrac... | 30,545 | [
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A new automated method for the determination of true creatinine in serum by means of the centrifichem centrifugal analyzer, based on Slot's principle; with special reference to low substrate concentrations. | A new automated method is proposed for the accurate determination of the true creatinine concentration in 20 microliter serum, based on the measurement of the initial rate of the decomposition reaction of the creatinine picrate complex caused by decreasing the pH. The results of this method, performed with a Centrifich... | 30,551 | [
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The effect of bile on the crystallisation of calcium carbonate, a constituent of gallstones. | When calcium and bicarbonate ions were mixed at room temperature (approximately 20 degrees C) to give concentrations of 4 mmol/1 and 21 mmol/1 respectively and the pH of the solution was kept at 8.3, vaterite, a form of calcium carbonate, was precipitated almost immediately as spheres of diameter 45 micron. The crystal... | 30,554 | [
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Comparative physiological disposition of ellipticine in several animal species after intravenous administration. | The physiological dispositon of ellipticine (NSC 71795) has been studied in the mouse, rat, dog and monkey after administration of [1-14C]ellipticine at 6 mg/kg iv (3 mg/kg to monkey). Ellipticine was very rapidly distributed from the blood of all species and was deposited in tissues. The rate of elimination of ellipti... | 30,602 | [
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[Biochemistry of depression. Literature analysis]. | The author goes briefly over the metabolism of the main cerebral monoamines, the functioning of synapses, as well as the methods used in studying the biochemistry of depression. Beyond all existing contradictory results, a review of the main works in this field enables us to point out some leading ideas:--Depression wo... | 30,616 | [
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Stimulation of immune reactivity by methoxy-substituted glycerol ethers incorporated into the feed. | In mice, the plaque-forming cell response to sheep red blood cells was stimulated by a mixture of methoxy-substituted glycerol ethers isolated from Greenland shark liver oil and by synthetic 1-0-(2-methoxyhexadecyl)-glycerol, given in the diet. In preliminary experiments, this synthetic compound also increased the abil... | 30,635 | [
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Reconstitution of rabbit muscle aldolase after dissociation and denaturation at alkaline pH. | Tetrameric rabbit muscle aldolase is dissociated to the inactive monomer at strongly alkaline pH (pH greater than or equal to 12). As shown by sedimentation velocity, fluorescence emission, and specific activity, the final profiles of dissociation, denaturation, and deactivation run parallel. Increasing incubation time... | 30,685 | [
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Nucleotides and coenzymes in nuclei isolated from rat liver. | In rat-liver nuclei, isolated by the non-aqueous technique, the concentrations and labelling rates of the purine moiety of acid-soluble nucleotides were determined and compared with corresponding data for non-fractionated tissue and nuclei-free cytoplasm. Livers were used from untreated rats, from rats with a highly st... | 30,690 | [
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Effect of pH on the growth and glucose metabolism of Neisseria gonorrhoeae. | This study examined the effect of pH on the metabolism of glucose by Neisseria gonorrhoeae. Radiorespirometric studies revealed that cells growing at pH 7.2 or 8.0 metabolized glucose primarily (ca. 80%) via the Entner-Doudoroff pathway. The remainder of the glucose was metabolized via the pentose phosphate pathway (ca... | 30,699 | [
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... |
Pharmacological treatment of obesity. | Obesity results when the ingestion of energy exceeds its utilization, leading to an excessive expansion of the adipose tissue mass. Current pharmacological therapy for the obese patient focuses primarily on reducing energy intake. Anorectic agents reduce food consumption by modifying central systems in the brain which ... | 30,732 | [
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Coordination chemistry of microbial iron transport compounds: rhodotorulic acid and iron uptake in Rhodotorula pilimanae. | The mechanism by which iron uptake is facilitated by the siderophore rhodotorulic acid (RA) in the yeast Rhodotorula pilimanae was investigated with radioactively labeled Fe and RA and kinetically inert, chromic-substituted RA complexes. The weight of the evidence supports a model in which RA mediates iron transport to... | 30,750 | [
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Clinical assessment of the safety and efficacy of lorazepam, a new benzodiazepine derivative, in the treatment of anxiety. | In a four-week double-blind study of 68 adult outpatients, lorazepam a new benzodiazepine, administered at an average total daily dosage level of 3.1 mg on a b.i.d. regimen, was clearly superior to placebo in the treatment of neurotic anxiety and its related symptoms. The lorazepam-treated group showed significantly gr... | 30,763 | [
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-... |
Lorazepam in anxiety associated with chronic enteritis and ulcerative colitis. | Using a common protocol, 9 gastroenterologists assessed the comparative antianxiety efficacy of lorazepam and placebo under double-blind conditions in 48 patients with moderate to severe anxiety associated with chronic enteritis and ulcerative colitis. The initial dose of lorazepam was 3 mg per day given b.i.d., 2 mg h... | 30,769 | [
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0.1883702,
0.006912218... |
The sensitivity of hemoglobin oxygen affinity to diphosphoglycerate and the characteristic pH of methemoglobin. | The sensitivity of the oxygen affinity of a hemoglobin to 2,3-diphosphoglyceric acid concentration has been defined as the change in log1/2O2 (deltalogp1/2O2) which results from saturating the hemoglobin with 2,3-diphosphoglyceric acid. The sensitivity varies from one hemoglobin species to another and is linearly rated... | 30,780 | [
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0.03586585,... |
Cobalamin binding and cobalamin-dependent enzyme activity in normal and mutant human fibroblasts. | We have studied the intracellular binding of radioactive cobalamin by normal cultured human fibroblasts grown in medium containing [(57)Co]-cobalamin. We have also assessed the significance of defects in this binding activity exhibited by two classes of human mutants (cbl C and cbl D) each characterized by pleiotropic ... | 30,783 | [
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... |
On testing the activity of proteases from human polymorphonuclear neutrophils on blood smears. | A cytochemical method is presented for the demonstration of proteases in human polymorphonuclear (PMN) neutrophils on fixed blood smears. This new technique is based on solubilization of proteases from PMN neutrophils by incubation with 0.25 M NaCl in borate buffer at pH 8.5 which leads to degradation of erythrocytes a... | 30,800 | [
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Microbiology of recurrent and chronic otitis media with effusion. | A study was conducted of 274 children who had recurrent acute or chronic otitis media with effusion. Forty-five percent of the ears with effusion were found to contain bacteria, and 11% contained bacteria that were "probable pathogens" (S. pneumoniae, H. influenzae, and S. pyogenes). Bacteria were also found in 40% of ... | 30,809 | [
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... |
Hemolytic properties of synthetic glycosides. | Cholesteryl alpha-L-rhamnopyranoside, tigogenyl alpha-L-rhamnopyranoside, tigogenyl beta-D-fucopyranoside, smilagenyl beta-D-fucopyranoside, cholesteryl beta-maltoside, tigogenyl beta-maltoside, and smilagenyl beta-maltoside were synthesized and characterized. The rhamnosides and fucosides, as well as some other steroi... | 30,839 | [
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-0.233... |
Antagonism by naloxone of narcotic-induced respiratory depression and analgesia. | Receptor mechanisms for narcotic-induced respiratory depression and analgesia were compared by apparent pA2 values of morphine-naloxone, levorphanol-naloxone and pentazocine-naloxone. The similarity of apparent pA2 values of the three compunds for respiratory depression suggests that morphine, levorphanol and pentazoci... | 30,841 | [
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... |
[Exoprotease properties of Bacillus subtilis var. amyloliquefaciens capable of coagulating blood plasma]. | The properties of the homogeneous exoprotease preparation from Bacillus subtilis varamyloliquefaciens 759 possessing the coagulase activity were studied. The enzyme is an alkaline protease, has the isopoint at pH 7.8, and not only clots blood plasmo but also hydrolyses such protein substrates as casein, hemoglobin, fib... | 30,884 | [
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[Dehydrogenase isoenzymatic spectrum of alanine, aspartic and glutamic acids in Candida albicans yeasts]. | The isoenzyme spectrum of dehydrogenases of alanine, aspartic and glutamic acids requiring NAD and NADP as cofactors was studied in Candida albicans. The spectrum of aspartate dehydrogenase was found to depend on a cofactor being used. The isoenzyme systems are related to proteins which posess various physico-chemical... | 30,885 | [
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[Isolation and properties of preparations the branching enzyme of muscles, amylose isomerase]. | The paper describes a modified method of isolating the branching enzyme of amylose isomerase from muscles and a study of the enzyme activity at different stages of purification. By enzyme fractionation on biogel R-150 and Sepharose 6B the fractions containing different RNA amounts have been isolated. The activity of fr... | 30,978 | [
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Physiologic monitoring goals for the critically ill patient. | Definition of the appropriate therapeutic goals for physiologic monitoring of patients postoperatively was approached by analyzing more than 50,000 values of the 20 most commonly monitored variables in a series of 113 critically ill patients throughout their immediate postoperative course. In general, normal values wer... | 31,006 | [
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3beta-Hydroxysteroid dehydrogenase activity in human fetal membranes. | A 3beta-hydroxysteroid dehydrogenase (3betaHSD) was demonstrated in term human fetal membranes (chorion and amnion) with both dehydroepiandrosterone (3beta-hydroxy-5-androsten-17-one) and pregnenolone (3beta-hydroxy-5-pregnen-20-one as substrates, and the subcellular distribution substrate and nucleotide specificity of... | 31,018 | [
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[Experience obtained in the treatment of recurrent aphthous stomatitis (author's transl)]. | Three different methods employed within the framework of complex therapy were used to treat 195 patients with recurrent aphthous stomatitis: 1. Alterative therapy using prodigiosan, a bacterial polysaccaride. 2. Desensitizing treatment using histaglobulin, an antihistaminic agent. 3. Symptomatic local treatment. The me... | 31,043 | [
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Comparison between agarose gel electrophoresis and isoelectric focusing of CSF for demonstration of oligoclonal immunoglobulin bands in neurological disorders. | Isoelectric focusing and agarose gel electrophoresis of CSF and serum revealed similar frequencies of oligoclonal bands in multiple sclerosis (100% with both methods), infectious CNS disorders (38 and 23%) and other neurological diseases (8 and 10%). In selected cases with unsure CSF oligoclonal bands on agarose gel el... | 31,050 | [
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0.049921... |
Effect of metrizamide on whole blood oxygen affinity. | The effects on whole blood oxygen affinity following addition to human blood of either ionic (diatrizoate) or non-ionic (metrizamide) contrast medium were investigated in vitro. No medium changed whole blood oxygen affinity. Solutions of metrizamide produced less changes in plasma pH than solutions of diatrizoate. This... | 31,064 | [
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The effects of fractions (chalones) obtained from lymphoid organs on the immune response in vivo. | Aqueous extracts of calf and pig lymphoid organs were prepared and fractionated by means of gel filtration, ion exchange chromatography, and isoelectric focusing. These fractions, which had been previously assessed on mitogen-stimulated mouse spleen lymphocytes and other cells in vitro, were tested for their in vivo ac... | 31,079 | [
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[Process of fumigatin and spinulosin formation by Aspergillus fumigatus Fres and polarographic assay of these toxins (author's transl)]. | A strain of Aspergillus fumigatus (Fresenius) isolated from a milk food for calves was grown on a culture medium containing added saccharose. The purpose was to study the synthesis of two recently discovered mycotoxins, fumigatin and spinulosin. The work was performed under many different conditions of temperature, pH ... | 31,124 | [
-0.0724629,
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0.1009094,
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0.07080879,
0.1808297,
0.3395172,
-0.09801136,
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-0.3849719,
-0.01909439,
-0.2563111,
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0.05136801,
-0.3796375,
-0.2415988,
0.1688256,
0.1646368,
0.3295825,
0.1048386,
-0.2265988,... |
Inosine nucleosidase from Azotobacter vinelandii. Purification and properties. | An enzyme catalyzing the hydrolysis of purine nucleosides was found to occur in the extract of Azotobacter vinelandii, strain O, and was highly purified by ammonium sulfate fractionation, DEAE-cellulose chromatography, hydroxylapatite chromatography and gel filtration on Sephadex G-150. A strict substrate specificity o... | 31,149 | [
-0.3300761,
0.0821755,
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0.02909354,
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0.06525831,
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0.4142289,
0.2015947,
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0... |
Effect of intravenous infusion of betasympathomimetic agents on plasma renin activity during pregnancy. | The plasma renin activity (PRA) was measured in 26 pregnant patients before and during ritodrine infusion (10 patients), during isoxsuprine infusion (12 patients), and during glucose infusion (4 control patients). All patients were in the third trimester of pregnancy, not in labour and not hypertensive. A low dose of r... | 31,167 | [
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0.3704226,
0.2556782,
0.048626... |
[Effect of neuromediators on acid-base status]. | A relationship between the state of adrenergic, cholinergic, and serotoninergic systems, on the one hand, and the acid-alkaline balance of the organism, on the other hand, was revealed in sharp and chronic experiments on dogs. A surplus of each of the mediators was accompanied by respiratory alkalosis, and its deficien... | 31,211 | [
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0.1816762,
0.0780027,
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0.0589647,
-0.07... |
Collateral sprouting in central mesolimbic dopamine neurons: biochemical and immunocytochemical evidence of changes in the activity and distrubution of tyrosine hydroxylase in terminal fields and in cell bodies of A10 neurons. | The olfactory tubercle of adult rats was examined for the development of collateral sprouts from intrinsic dopaminergic axons following unilateral olfactory bulbectomy. In the ipsilateral tubercle tyrosine hydroxylase (TH) activity began to increase by 10-14 days following the lesion, gradually reaching a maximum of 12... | 31,232 | [
-0.1938866,
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0.2219074,
0.2473371,
0.2086677,
0.04796401,
... |
Pheochromocytoma in the modern context. | The hypertensive patient faces an uncertain future. Therefore a search for those cases in which the condition is potentially curable is eminently worth while and has become increasingly productive because of the specific diagnostic aids now available and because of the present safety of surgical intervention. Detection... | 31,234 | [
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0.3286186,
0.158901,
0.0472624,
0.01403808,
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... |
A technique for the measurement of breakage and repair of DNA alkylated in vivo. | The alkaline elution technique has been adapted for use in the assessment of DNA damage induced in the livers and lungs of mice after administration of an alkylating agent, methylemthanesulfonat (MMS). At 4 h after administration of MMS, damage ot DNA was readily demonstrable; the damage was repaired in liver by 24 h. ... | 31,244 | [
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0.05875784,
0.03596433,
0.5224789,
0.3727058,
-0.2281545,
-0.1738042... |
Sphingolipid composition and catabolism in human fetal tissues. | Human fetal tissues derived from prostaglandin-induced abortuses (9--18 wk fertilization age) have been utilized to evaluate sphingolipid composition and catabolism. Sphingolipid composition (lipid-hexose, sulfatide, and lipid-bound NANA) was assessed in fetal brain. Sphingolipid catabolism was evaluated in fetal lung ... | 31,273 | [
-0.007771267,
0.03972162,
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0.4612818,
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0.2279374,
0.2311535,
0.7548117,
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... |
Cobalt hemoglobin: pH dependence of Adair constants and the Bohr effects. | Precise oxygen equilibrium curves have been obtained for cobalt hemoglobin at pH values from 5.5 to 8.2. The Hill plots are symmetric having asymptotes with slopes of unity. At pH 7.0, cobalt hemoglobin has p0.5 = 116 toor (15.45 kPa), pm = 117 torr (15.58 kPa) and a Hill coefficient of n = 1.72. The values of n decrea... | 31,286 | [
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0.4571566,
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0.02466574,
0.2999145,
0.1026196,
0.1095178,
... |
Assessment of a dental anxiety scale. | A number of different sets of data concerning the Corah Dental Anxiety Scale were evaluated. The data indicate that the scale is a reliable, valid, and useful measure of dental anxiety. It can be successfully used in the dental office or in research projects. | 31,377 | [
-0.3589553,
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0.1023235,
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0.2109237,
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0.1207087,
0.3787456,
0.1088756,
0.1098072,
0.... |
Pyridoxal phosphatase: cytochemical localization in GERL and other organelles of rat neurons. | A phosphatase, hydrolyzing pyridoxal-5-phosphate (P5P), a physiologically active component of the vitamin B6 complex and an essential co-enzyme in the synthesis of neurotransmitters, has been localized cytochemically in the perikarya of neurons in the peripheral, autonomic and central nervous systems of the rat. Neuron... | 31,396 | [
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0.04245161,
0.3321497,
0.06228445,
0.... |
Some characteristics of Ureaplasma urealyticum. Urease activity in a simple buffer: effect of metal ions and sulphydryl inhibitors. | Urealytic activity of the cytoplasmic fraction of Ureaplasma urealyticum prepared by digitonin lysis was assayed in a simple buffer system (HEPES plus EDTA) by measuring the release of 14CO2 from [14C]urea. The Km of this preparation agreed with our previous observations of the same activity measured in a more complex ... | 31,413 | [
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0.3322541,
0.3002334,
-0.07327687,
... |
Frightening dreams and dosage schedule of tricyclic and neuroleptic drugs. | One previous study reported that psychiatric inpatients on bedtime-only doses of tricyclic or neuroleptic drugs reported more frequent frightening dreams than did those on divided daily doses. As a further test of this hypothesis, and in order to see whether differences in frequency of frightening dreams were a functio... | 31,416 | [
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-0.01801051,
0.027632... |
Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 4. Central nervous system depressants. | The synthesis of 1'-[3-(4-fluorobenzyoyl)propyl]-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] (2a) and eight halo and methoxy analogues is described. The compounds were generally more potent per os than chlorpromazine in the Sidman avoidance paradigm in rats and less potent than haloperido. 1'-[3-(4-Fluorobenzoyl)p... | 31,478 | [
-0.3397121,
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0.1250739,
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0.1500146,
0.05316991,
-0.0... |
Neuroleptics related to butaclamol. An investigation of the effects of chlorine substituents on the aromatic rings. | The synthesis of analogues of the antipsychotic drug butaclamol bearing chloro substituents on the benzene rings is described. On the basis of a perceived topographical similarity of a putative chlorophenylethylamine pharmacophore present in these analogues and in VUFB-10032 and doclothepin, agents related to octocloth... | 31,480 | [
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0.3099006,
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0.1774928,
-0.1316531,
0.4432468,
-0.1644357,
... |
(exo, exo)-2-Aryltropane-3-carboxylic esters, hypoglycemic agents with accompanying analgesic activity. | (exo, exo)-2-Aryltropane-3-carboxylic esters of types 6, 7, and 10 lower circulating blood glucose levels by 60--80%. This activity is accompanied by an analgesic activity roughly equal to that of codeine. Both of these activities reside in the 1R enantiomer and extensive structure-activity studies failed to separate t... | 31,482 | [
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0.1000862,
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0.1162204,
0.3239046,
0.2336161,
0.003161216,
0.09022658,
-0.1412229... |
Cardioselectivity as a function of molecular structure in beta-adrenoceptor blocking agents of the 1-(para-substituted aryloxy)-3-(isopropylamino)propan-2-ol type. | The relationship between molecular structure and cardioselectivity is described in the 1-(para-substituted aryl-oxy)-3-(isoprophylamino)propan-2-ol type of beta-adrenoceptor blocking agents. Cardioselectivity in the aforementioned series requires that the aromatic substitution in the position para to the amino alcohol ... | 31,488 | [
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0.1834432,
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0.2355531,
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0.2964598,
0.1229394,
0.1601628,
-0.00507... |
Fatty acid biosynthesis in yeast. | Fatty acid synthetase and acetyl CoA carboxylase mutants have been used to study several aspects of fatty acid biosynthesis in yeast: the contribution of the various enzymes of fatty acid biosynthesis and modification to the overall cellular fatty acid composition, the mechanism of fatty acyl chain elongation in yeast,... | 31,559 | [
-0.02746779,
0.1507148,
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0.1374329,
0.1478375,
0.3919573,
0.2720856,
0.4127764,
-0.3063024,
-0.... |
Continuous fetal tissue pH measurement in labor. | Fifty-one women in labor had continuous monitoring of fetal scalp tissue pH, fetal heart rate by ECG, and uterine contractions. A miniature pH electrode secured by a double spiral fetal ECG electrode was used for measurement of fetal pH every 15 seconds. The results were correlated with fetal scalp blood pH values obta... | 31,584 | [
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0.166618,
0.07900228,
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0.1608664,
0.1079406,
0.03944106,... |
Studies on proliferation kinetics in liver and spleen during early graft-vs-host reaction in mice. | Autoradiographic and liquid scintillation counting studies were made during the early graft-versus-host-reaction in mice. At the height of GVHR on the 10th day after transplantation, hepatosplenomegaly correlated with the radioactive disintegrations (DPM). This coincided with a high proliferation rate of the blasts tha... | 31,609 | [
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0.2127162,
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0.1352725,
0.1387065,
0.298263,
0.4296948,
0.09189626,
0.02739746,
... |
[The role respiratory acidosis in the development of acute pancreatitis (author's transl)]. | The effects of respiratory acidosis on the pancreas were studied in 25 Wistar rats. Ligation of the duct combined wiht respiratory acidosis resulted in the development of acute pancreatitis. In explantation of the results it is suggested that exhaustion of the buffering capacity causes a dramatic fall in pH of the pan... | 31,613 | [
-0.001241404,
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0.1031931,
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0.002329459,
0.1595555,
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0.05248144,
0.06009325,
0.06592865,
0.254837,
-0.1081092,
0.058... |
Drug response and psychiatric nosology. | The possibility that pharmacological response might help to refine psychiatric nosology has been the subject of recurrent speculation, but few clear-cut results have been obtained. Only bipolar depressives and several other minor patient subgroups manifest consistent drug responses in association with characteristic ps... | 31,647 | [
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0.03437959,
0.02904647,
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0.297175,
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0.06798493,
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0.2986889,
0.2068742,
0.3166643,
0.1754562,
0.1026585,
-0.1144465,
-0... |
Effects of LSD and BOL on the catecholamine synthesis and turnover in various brain regions. | In the rat, lysergic acid diethylamide (LSD) 0.5 mg/kg and 2-bromo lysergic acid diethylamide (BOL) 0.5 mg/kg increased the rate of the striatal in vivo tyrosine hydroxylation as measured by the DOPA accumulation after decarboxylase inhibition. Neither LSD nor BOL significantly changed the DOPA accumulation in the olfa... | 31,650 | [
0.1000822,
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0.07135957,
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0.1621963,
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0.5186291,
0.3319128,
0.2032507,
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0.3102986,
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0.04330412,
0.18315,
0.262845,
0.2760043,
0.4550385,
-0.008765621,
-0.... |
The use of percutaneous nephrostomy and urinary alkalinization in the dissolution of obstructing uric acid stones. | Two patients are described who presented with complete urinary obstruction secondary to nonopaque uric acid stones. They were treated with percutaneous nephrostomy for urinary diversion and urinary alkalinization by local irrigation and oral sodium bicarbonate therapy with complete dissolution of the stone after 16 and... | 31,657 | [
-0.259823,
0.2491365,
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0.07132218,
-0.03260776,
-0.2568528,
-0.4135189,
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0.2603633,
0.2067532,
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0.0892399,
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0.06685653,
-0.1688172,
-0.1084365,
-0.3387755,
-0.007674069,
0.1828249,
-0.1484... |
ECT in the treatment of recurrent psychotic depression. | Two cases of recurrent psychotic depression are reported in which ECT (electroconvulsive therapy) was administered with good results for previous episodes of depression, but treatment of the current episode with combined drug therapy (antidepressant and antipsychotic drugs) in one case and antidepressant chemotherapy i... | 31,690 | [
-0.2083494,
0.07909729,
-0.2069077,
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0.3080233,
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0.2707067,
0.1102852,
0.4570446,
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0.3749296,
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-0.2028372,
0.3729809,
-0.1160783,
-0.004298779,
-0.001778379,
0.02888251,
0.0762366... |
Orchiopexy in prepubertal boys. Five-year survey. | A series of 141 prepubertal boys with undescended testes operated on in a provincial teaching hospital has been analyzed five years after operation. The main features noted at presentation were the mature age of the patients and the small number of boys referred by pediatricians. The incidence of unsatisfactory results... | 31,726 | [
0.08181908,
0.1558059,
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-0.001138595,
-0.1722232,
0.4905257,
0.2724635,
-0.08710... |
Influence of morphine anaesthesia on the endocrine-metabolic response to open-heart surgery. | Twelve patients scheduled for aortic valve replacement during extracorporal circulation were randomly allocated to either morphine anaesthesia or fluroxene anaesthesia. Morphine in a total dose of 4 mg/kg was administered before skin incision. At the start of extracorporal circulation all patients received 25 g glucose... | 31,757 | [
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0.0963537,
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0.05419594,
0.008160491,
0.3043273,
0.6882108,
0.3076591,
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0.17... |
Thermal and vortical stability of purified human fibroblast interferon. | The loss of biological activity upon heating or agitation of human interferons is markedly altered by changing their aqueous environment. Low pH significantly stabilizes liquid fibroblast interferon at 68 degrees C and 37 degrees C whereas chaotropic salts stabilize at 68 degrees C but not at 37 degrees C; this anomalo... | 31,770 | [
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0.4898004,
-0.09980945,
0.06133958,
-0.... |
Cefoxitin sodium compatibility with intravenous infusions and additives. | The compatibility and stability of cefoxitin sodium in solution with a series of frequently used intravenous infusion fluids and injectable additives were studied. Cefoxitin sodium's stability in various solutions was measured by ultraviolet spectrophotometry, iodometry, thin-layer chromatography, high-pressure liquid ... | 31,790 | [
0.08554006,
0.1986999,
-0.416077,
-0.2476874,
0.1435175,
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0.2092752,
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0.4066114,
0.3588944,
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-0.1045279,
-0.07952233,
0.1878365,
0.1852464,
-0.1021611,
0.3093893,
0.1... |
Pancreatic response to intestinal perfusion with lactic acid or acidified albumin. | To test the hypothesis that the permeability of weak acids across the intestinal mucosa affects their ability to stimulate pancreatic bicarbonate output, we compared pancreatic bicarbonate secretion in response to intestinal perfusion with an acid presumed to be permeable to cell membranes, lactic acid (90 daltons), an... | 31,795 | [
0.03283851,
-0.4678461,
-0.154387,
0.1473503,
0.1897998,
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-0.103627,
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0.1492793,
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-0.3214158,
0.1309998,
0.1049592,
-0.03089205,
0.02701493,
0.0210322,
0.1420... |
[Influence of age on biochemical parameters of the rat liver following partial hepatectomy (author's transl)]. | In the present paper measurements of DNA and protein content and lysosomal enzyme (beta-glucuronidase, beta-acetylglucosaminidase, cathepsin D) acitivities were performed in the rat liver following partial hepatectomy. The rats were divided into three age groups: 6 weeks, 10 months and 18 months. The regenerating liver... | 31,815 | [
0.1790676,
-0.4323066,
-0.1843735,
0.1989238,
0.1723687,
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0.08107406,
0.2960085,
0.151566,
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0.1874425,
0.2082651,
0.4736637,
0.1954205,
0.2077585,
-0.2944594,
0.128... |
The effect of beta adrenergic blockade on pulmonary hypertension, right ventricular hypertrophy and polycythaemia, induced in rats by intermittent high altitude hypoxia. | Adult male rats were used to study the effect of a beta blocking agent on pulmonary hypertension and right ventricular hypertrophy induced by intermittent high altitude (IHA) hypoxia (8 hr daily, 5 days a week, stepwise up to the simulated altitude of 7000 m). Trimepranol was injected subcutaneously in a single dose of... | 31,862 | [
-0.166112,
-0.04664395,
-0.5191454,
-0.270924,
0.1688524,
-0.37503,
-0.07398722,
-0.2523374,
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-0.07260831,
0.03866576,
0.4600519,
0.09443931,
-0.1020675,
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0.1523316,
-0.3967144,
0.0810947,
-0.07708949,
0.1435461,
-0.1961422,
0.1750196,
-0.07420072,
... |
Sequence of reactions which follows enzymatic oxidation of allylglycine. | The pathway following flavoprotein-catalyzed oxidation of allylglycine (2-amino-4-pentenoate) has been studied and found to be dependent on the incubation conditions. In N-2-hydroxyethyl-N'-2-ethanesulfonic acid (Hepes) buffer, the oxidation product 2-iminium-4-pentenoate predominantly reacts to form 2-amino-2,4-pentad... | 31,909 | [
-0.3321917,
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0.3809631,
0.1383944,
0.2206455,
0.2548893,
0.3141805,
-0.1433177,
0... |
Proton stoichiometry of the cytochrome c peroxidase mechanism as a function of pH. | The proton stoichiometry for the oxidation of cytochrome c peroxidase (ferrocytochrome c: hydrogen-peroxide oxidoreductase, EC 1.11.1.5) to cytochrome c peroxidase Compound I by H2O2, for the reduction of cytochrome c peroxidase Compound I to cytochrome c peroxidase Compound II by ferrocyanide, and for the reduction of... | 31,913 | [
-0.3876647,
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0.3115311,
0.1386767,
0.0086542,
0.08828421,
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0.1522705,
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-0.04327451,
0.1839331,
0.04811829,
0.3535459,
0.195086,
0.07085232,
... |
13C NMR investigations on Npi-[13C1]carboxymethyl-histidine-119 ribonuclease. | The ribonuclease A derivative Npi-[13C1]carboxymethyl-histine-119 ribonuclease prepared by using [13C1]bromoacetate as alkylating reagent has been investigated with high resolution 13C NMR spectroscopy. In the 13C NMR spectra two carbon resonances of relatively high intensity appear which can be assigned to carboxyl gr... | 31,923 | [
-0.2373729,
0.08908352,
0.1284054,
0.14733,
0.1242049,
0.04353654,
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0.2899896,
-0.03519423,
0.4247976,
0.2604869,
0.1479511,
-0.04427477,
-0.0... |
Studies on the succinate dehydrogenating system. I. Kinetics of the succinate dehydrogenase interaction with a semiquindiimine radical of N,N,N',N'-tetramethyl-p-phenylenediamine. | 1. The activities of the soluble reconstitutively active succinate dehydrogenase (EC 1.3.99.1) measured with three artificial electron acceptors, e.g. ferricyanide, phenazine methosulfate and free radical of N,N,N',N'-tetramethyl-p-phenylenediamine (WB), have been compared. The values estimated by extrapolation to infi... | 31,933 | [
-0.3865831,
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-0.247942,
0.2882471,
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0.3368663,
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0.1618761,
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0.3313335,
0.2261152,
0.1817467,
-0.07555193,
... |
Characterization of two quenchers of chlorophyll fluorescence with different midpoint oxidation-reduction potentials in chloroplasts. | The properties of two redox quenchers of chlorophyll fluorescence in chloroplasts at room temperature have been investigated. (1) Redox titration of the fluorescence yield reveals two n = 1 components with Em7.8 at--45 and --247 mV, accounting for approx. 70 and 30% of the total yield, respectively. (2) Neutral red, a ... | 31,935 | [
-0.2762845,
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-0.08840381,
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0.1464494,
0.2192291,
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0.3784795,
0.1056266,
0.2316942,
0.198791,
0.3115995,
0.187097,
0... |
Early increase in phenylethanolamine-N-methyltransferase activity in a new strain of spontaneously hypertensive rats. | By repeated inbreeding, 2 strains of spontaneously hypertensive and normotensive rats have been simultaneously selected. The activities of tyrosine hydroxylase and phenylethanolamine-N-methyltransferase were determined in various central catecholaminergic nuclei (C1, C2, A6 and A9) and in two peripheral tissues (adrena... | 31,964 | [
0.04063341,
0.0529338,
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-0.03882503,
0.08645691,
0.3809859,
0.1449232,
0.1662039,
-0.2663003,
0.171925... |
DNA-dependent RNA and polyadenylic acid polymerase from phototrophically grown Rhodospirillum rubrum. | DNA-dependent RNA and polyadenylic acid polymerases have been purified from phototrophic Rhodospirillum rubrum. Their properties have been found to be very similar to those of the previously reported heterotrophic R. rubrum enzymes. However, several important differences do exist between the enzymes from the phototrop... | 31,974 | [
-0.2276764,
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-0.2307528,
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0.1601409,
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0.228864,
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0.05471057,
0.5207295,
0.06193403,
-0.2570774,
-... |
Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension. | 1. Hypertension was induced in rats by renal artery clip with the contralateral kidney removed (Goldblatt I) or left intact (Goldblatt II). 2. Plasma noradrenaline was increased 62% in the Goldblatt I animals after 3 weeks. 3. Hypothalamic tyrosine hydroxylase and dopamine beta-hydroxylase activities, and the concentra... | 32,000 | [
0.1065572,
0.1183584,
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0.3837456,
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0.06485854,
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0.008305913,
0.01189085,
0.248713,
-0.3536368,
... |
Acute influence of different beta-blocking agents upon left heart hemodynamics at rest and during exercise in patients with coronary artery disease. | The study investigated the acute hemodynamic changes induced in patients with angiographically confirmed coronary artery disease by 3 beta-blockers: metoprolol, cardioselective without intrinsic sympathomimetic activity (ISA), group I, 11 patients; bunitrolol, noncardioselective with ISA, group II, 11 patients; oxpreno... | 32,041 | [
-0.2228868,
0.3096029,
-0.4366814,
-0.0831074,
-0.1837519,
-0.1725546,
-0.4126548,
-0.3166508,
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-0.147204,
0.09920233,
0.1284708,
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-0.4089051,
0.3158672,
-0.286828,
0.39389,
-0.002697517,
0.01998263,
-0.1225571,
... |
Comparison of disposition and effect of timolol and propranolol on exercise tachycardia. | The kinetic disposition and beta-adrenergic blocking action in relation to plasma level of a single oral dose of either timolol or propranolol has been compared in healthy male volunteers. The disposition profiles clearly disclosed different properties of the two drugs, although their half-lives were similar. The avail... | 32,043 | [
-0.2699764,
0.2605842,
-0.6828468,
-0.2953427,
0.306285,
-0.4408941,
-0.4175968,
-0.2239305,
-0.08325513,
-0.3423521,
-0.0473382,
0.04190825,
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0.1352364,
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-0.4514067,
0.2841126,
-0.05887345,
0.3422545,
-0.04489009,
0.3140921,
0.05224629,... |
A relatively specific and quantitative assay for histamine H2-receptor blocking activity by determination of inhibition of histamine-induced gastric acid secretion in the rat. | A relatively specific method for the quantitative assay of histamine H2-receptor antagonists has been developed. The method is based on the antagonism of the histamine-induced, and the spontaneous, gastric acid secretion in the stomach-perfused, urethane-anesthetized acute rat. For the induced gastric acid secretion, t... | 32,047 | [
-0.07013038,
-0.3901021,
-0.1422067,
-0.0919482,
0.354905,
0.1774458,
-0.05719565,
-0.2508302,
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0.1216075,
0.09202366,
0.07049628,
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0.1579537,
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0.09017387,
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0.1722684,
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0.1051737,
0.08528234,
0.0155942,
0.2393733,
... |
Blockade by WB 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci. | The effectiveness of WB 4101, a recently described alpha-adrenoceptor antagonist, in blocking an excitatory and two inhibitory responses to alpha-receptor activation was studied. One of the inhibitory responses was the reduction by the selective alpha-agonist amidephrine of carbachol contractures of isolated guinea-pig... | 32,052 | [
0.1842213,
0.1299084,
-0.1543825,
-0.6925712,
0.3736925,
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0.01476953,
0.06385136,
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0.07504606,
0.4530277,
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0.2505682,
0.1913641,
-0.1084604,
0.02805004,
0.3408778,
-0.01869092,
0.... |
A difference in effects of physiological Ca2+ concentrations on activity of guanylate cyclase preparations obtained from the taenia caecum of guinea pig and from the longitudinal muscle of rat duodenum. | A cholinergic stimulant, butyltrimethylammonium bromide and serotonin increased the tissue levels of cyclic GMP in the taenia caecum of guinea pig but not those in the longitudinal muscle of rat duodenum. On the other hand, physiological Ca2+ concentrations enhanced the activity of a guanylate cyclase preparation obtai... | 32,054 | [
-0.06954501,
-0.3244919,
-0.4260839,
-0.1685364,
0.008649664,
-0.1413325,
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-0.02560182,
0.1875385,
0.228377,
0.1216913,
0.06599... |
Antagonism of central histamine H1 receptors by antipsychotic drugs. | The activity of 8 widely antipsychotic drugs as antagonists of central histamine H1 receptors was determined from the inhibition of the binding of 3H-mepyramine to a membrane fraction from guinea-pig brain. The phenothiazines examined, clorpromazine, fluphenazine, thioridazine and trifluoperazine, were all potent H1 an... | 32,056 | [
-0.08788863,
0.08592641,
-0.03559708,
-0.1874637,
0.2606492,
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0.08069126,
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0.01989843,
0.2160102,
0.1414592,
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-0.58413,
0.1547253,
-0.1312869,
0.2589888,
-0.1843217,
-0.02826066,
0.03773824... |
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