title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA). | Certain D-arabinosyl nucleosides, notably arabinosyl cytosine (araC) and arabinosyl adenine (araA), are useful in the treatment of certain leukemias and some DNA virus infections, respectively. The compounds are lethal to animal cells and some bacteria. Despite extensive deamination, the parent nucleosides are transpor... | 328,134 | [
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Distribution, ontogeny and ultrastructure of the mammalian secretin cell. | Immunocytochemically, secretin cells have been demonstrated to occur in the duodenum and jejunum of several mammals. Calculations on the relative frequency of such cells indicate that the bulk of secretin occurs in the jejunum, a fact supporting the view that secretin may be released by physiological stimulants other t... | 328,159 | [
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Immunofluorescent localization and ultrastructural characterization of gonadotrophe cells in the adenohypophysis of the barbary drake (Cairina moschata L.) using anti-chicken LH serum. | An indirect immunofluorescence technique and an anti-chicken LH serum were used to localize cells in the adenohypophyses of drakes at different stages of their breeding cycle, after castration, and after castration combined with thyroxine treatment. Immunofluorescent cells were distributed throughout both lobes of the ... | 328,161 | [
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Calcium containing particles in mitochondria of heart muscle cells as shown by cryo-ultramicrotomy and X-ray microanalysis. | Mitochondria of normal myocardial cells of the sand rat and the mouse as well as of the left ventricle of man, have been examined for their content of calcium. Ultrahistochemistry and X-ray microanalysis revealed two basically different inclusions: Osmiophilic mitochondrial granules and spherical mitochondrial particle... | 328,164 | [
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Drug kinetics in pregnancy. | Any drug given to a pregnant woman must be considered as possibly harmful in the fetus, since all drugs administered to the mother cross the placental membrane, although at different rates. Important physiological changes occur in pregnancy, which may influence the kinetics of drugs. Differences in gastrointestinal fu... | 328,205 | [
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Renal osteodystrophy--a radiological review. | Renal osteodystrophy is an amalgam of a number of distinct pathological conditions, in particular, hyperparathyroidism and osteomalacia. In addition, there may be a change in the guantity of bone, i.e., osteopenia (osteoporosis) or osteosclerosis. While bone biopsy may be the most reliable method for detecting these le... | 328,228 | [
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Stimulation of glucagon release by addition of anti-stomatostatin serum to islets of Langerhans in vitro. | Addition of anti-somatostatin serum to rat islets of Langerhans which had been previously maintained in organ culture for 48h, resulted in a marked stimulation of glucagon release with no change in the rate of insulin secretion during the entire 90 min period during which the secretion of both hormones was followed. Pr... | 328,268 | [
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L-Ornithine carbamoyltransferase from Saccharomyces cerevisiae: steady-state kinetic analysis. | Ornithine carbamoyltransferase of Saccharomyces cerevisiae is subjected to an enzymatic regulation of its anabolic activity when it is bound to the inducible catabolic arginase as described earlier. This regulatory ornithine carbamoyltransferase essentially catalyzes the synthesis of citrulline, but the reverse reactio... | 328,278 | [
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A trypsin-resistant fragment from complexes of ribosomal protein S4 with 16-S RNA of Escherichia coli and from the uncomplexed protein. | A fragment of ribosomal protein S4 was prepared by limited trypsin degestion of a specific complex between protein S4 and 16-S RNA. It was characterised for amino acid sequence and the N-terminal 46 amino acids were found to be absent. An intermediate fragment, cut at Arg-43, was also observed at low trypsin concentrat... | 328,283 | [
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[Metabolic fate of carteolol hydrochloride (OPC-1085), a new beta-adrenergic blocking agent. (6) Pharmacokinetics of carteolol in the rat, dog, rabbit and man]. | The kinetics (absorption, distribution and excretion) of carteolol were investigated after oral and intravenous administration to man, rats, Beagle dogs and rabbits. The half-life of carteolol in plasma was 1.22 approximately 1.45 hr in rats, 1.73 approximately 2.08 hr in dogs and 1.42 approximately 1.43 hr in rabbits,... | 328,355 | [
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Role of endotoxin contamination in ribiosomal vaccines prepared from Salmonella typhimurium. | Ribosomal vaccines prepared from Salmonella typhimurium SR-11 and 6707 an Re mutant bacterium of strain LT2, were effective immunogens in A/J and C3H/HeDub inbred mice. Only SR-11 ribosomes were able to induce significant protection in C3H/HeJ mice. C57BL/6J mice were not protected by either ribosomal preparation. A/J ... | 328,399 | [
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Computer simulation of medical reasoning in the assessment of kidney disease. | A system for the simulation of clinical reasoning was applied to the evaluation of patient data in nephrological diseases. The system allows the physician to computerise the medical logic in his area of specialisation, to prepare suitable protocols for recording clinical observations, to analyse the patient data for as... | 328,412 | [
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Echocardiography in congenital heart disease. An aid to surgical diagnosis. | Echocardiography is an important noninvasive method for accurately diagnosing many congenital cardiac defects. This method provides significant information so that cardiac surgery, when necessary, can be planned with greater facility. The value of the sonar method rests not only on its ability to diagnose specific card... | 328,431 | [
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[Cryomacroglobulinemic purpura with liver cirrhosis and hepatic porphyria]. | Hepatic porphoria and histologically verified cirrhosis, teleangiectasia, purpose, papular skin lesions existing for eight years, as well as cryomacroglobulin were found in a 49 year old man. Pathogenetically the liver disease is considered to be the primary event, which was accompanied by secondary cryoglobulinemia. I... | 328,452 | [
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Two systems for the uptake of phosphate in Escherichia coli. | Mutants of Escherichia coli K-12 were constructed such that each possessed one single major system for phosphate transport. A comparison of these strains showed that one of the systems (PIT) was fully constitutive, required no binding protein, and operated in spheroplasts. It permitted the complete exchange of intracel... | 328,484 | [
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Secondary promoter of the guanine operon of Escherichia coli K-12. | Evidence of a secondary promoter for the guaA gene within the guaB gene was obtained by using lambdapguaA transducing phage. The technique is generally applicable to distinguish a promoter present within a bacterial deoxyribonucleic acid segment, which has replaced the lambda b2 region of transducing phage, from the ph... | 328,493 | [
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Clinical trial with "R-75" strain live, attenuated, serum inhibitor-resistant intranasal influenza B vaccine. | The "R-75" strain live, attenuated, serum inhibitor-resistant influenza B vaccine was administered intranasally by drops in two doses 14 days apart to 21 volunteers. Each vaccinee was paired with a close associate (roommate or workmate) who similarly received two doses of a placebo solution. Although about 50% of both ... | 328,526 | [
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Selective and enhanced recovery of group A and B streptococci from throat cultures with sheep blood agar containing sulfamethoxazole and trimethoprim. | Sheep blood agar containing 23.75 microgram of sulfamethoxazole and 1.25 microgram of trimethoprim (SXT-BA) per ml was compared with conventional sheep blood agar (SBA) for isolating group A and B streptococci from throat cultures. This selective medium allowed much better recovery of group A and B streptococci and sup... | 328,529 | [
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CAMP-disk test for presumptive identification of group B streptococci. | The modification of the CAMP test for goup B streptococci involved substituting a paper disk impregnated with partially purified beta-hemolysin for the staphylococcal culture that was the source of beta-hemolysin in the original test. The disk is placed onto a sheep blood agar plate beside the streak of Streptococcus b... | 328,534 | [
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Comparison between the automated reagin test and reagin screen test methods of VDRL screening tests for syphilis in use in a routine laboratory. | A comparison is made between the automated reagin test (ART) using Technicon AutoAnalyzer equipment and the reagin screen test (RST) introduced by Lederle using a new antigen formulation. Treponemal haemagglutination tests (TPHA) were done simultaneously as second screen tests. The absorbed fluorescent treponemal antib... | 328,538 | [
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Review of ADA licensure policy. | ADA policies on licensure encourage states to ease mobility restrictions while maintaining sufficient control to ensure that only qualified individuals provide dental treatment within the state. Many states have had provision to license by credentials for a long time. Licensure by credentials is rapidly replacing recip... | 328,550 | [
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Physicochemical consequences of opsonization: perturbation of liposomal membranes by Salmonella typhimurium 395 MS opsonized with IgG antibodies. | When phagocytosis-resistant Salmonella typhimurium 395 MS bacteria sensitized with anti-MS IgG antibodies were incubated with liposomes composed of phosphatidylcholine, cholesterol, and dicetylphosphate, a previously sequestered liposomal marker (4-methylumbelliferylphosphate) was released. Unsensitized or F(ab')2-sens... | 328,778 | [
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Parasitologic and serologic observations of infection with Pneumocystis in humans. | More than 500 specimens of lung tissue were examined for Pneumocystis. Of the 38 infections detected, most were in immunodeficient patients. Samples of serum from approximately 600 healthy normal subjects and 117 children with acute lymphatic leukemia were examined by an indirect fluorescent antibody test. The age-rela... | 328,785 | [
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Serious cerebral complications following unilateral ligation of the internal jugular vein. Review of the literature and a case report. | Serious intracranial sequelae of unilateral internal jugular vein ligation or resection are extremely rare. 22 cases including our own, were found in the literature, eight of them with a fatal outcome. Factors involved such as abnormalities of the cerebral venous sinus system, controlled hypotension, hypovolemia, postu... | 328,808 | [
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Glycolytic, hexose monophosphate shunt and bactericidal activities of leukocytes in ascorbic acid deficient guinea pigs. | It is well known that glycolytic and hexose monophosphate shunt activities of leukocytes increase during phagocytosis. The relevance of these metabolic changes to particle uptake and particle destruction is also well established. In the present study, these metabolic activities were studied to assess the phagocytic fun... | 328,832 | [
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Collection and physiological measurements of peripheral lymph and interstitial fluid in man. | Methods used for collection and measurement of physiological parameters of peripheral lymph and interstitial fluid in man have been described, basing on the experience of lymphological groups from Warsaw and Oslo and on data from the relevant literature. The review consists of description of methods for chronic cannula... | 329,010 | [
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VEP and SEP in non-specific thalamic nuclei and pulvinar during stereotaxic surgery. | This report is based on recordings of evoked photic (VEP) and somatosensory response (SEP) from the thalamic nuclei and cortex of 17 humans during stereotaxic surgery. The cortical SEP and VEP have relatively uniform patterns. The initial latency of the cortical VEP is shorter than that of SEP. Both thalamic SEP and VE... | 329,155 | [
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Harmful effects of "aspirin compounds". | "Aspirin" is the most widely used medication which is considered to be safe and effective, and which can be obtained universally without prescription. A review of the literature and clinical experience reveal that many complications can be attributed to the prolonged use of it. Some of these complications involve damag... | 329,172 | [
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Protection against experimental necrotizing enterocolitis by maternal milk. I. Role of milk leukocytes. | A rat model of necrotizing enterocolitis of the neonate in which maternal milk had been protective was studied to determine what components of the milk afforded protection and by what mechanism. Frozen and thrawed rat milk was not protective, but formula supplemented with rat milk cells was. It was concluded that the c... | 329,204 | [
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[Wound healing in viscera studied using a hemostatic gelatin-starch sponge of Polish manufacture]. | The authors studied the reaction of liver, spleen and kidneys in rats to the implantation of Polish made hemostatic gelatin-starch sponge. The sponge under study evoked no disadvantageous tissue reactions in the case of liver; it was readily resorbed and did not inhibit the wound healing. It facilitated the healing of ... | 329,242 | [
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[Renal transplantation: results and conditions for donor-nephrectomy (author's transl)]. | The role of renal transplantation as a method of treatment of chronically uraemic patients is presented considering recent data. The number of chronically haemodialysed patients is 64,0000 in the world. About 20,000 kidneys have been transplanted. In spite of advantages of a combined treatment by dialysis and transplan... | 329,262 | [
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Nucleic acid helix-unwinding properties of ribosomal protein S1 and the role of S1 in mRNA binding to ribosomes. | The presence of ribosomal protein S1 in 30S ribosomes is indispensable for the formation of 30S initiation complexes with natural mRNA. The 30S subunits lacking S1 retain activity with AUG as mRNA and are also active in poly(rU)-directed binding of Phe-tRNA. Isolated protein S1 stoichiometrically disrupts the secondary... | 329,281 | [
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Selection of reconstituted cells from karyoplasts fused to chloramphenicol-resistant cytoplasts. | Murine Balb/3T3 and murine A-MT-BU-A1 mammary tumor cells were separated in the presence of cytochalasin B into enucleated cytoplasmic components (cytoplasts) and nucleated subcellular components (karyoplasts). Karyoplasts were derived from 3T3 cells, while cytoplasts were derived from A-MT-BU-A1 cells that were both c... | 329,286 | [
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Baclofen (para-chlorphenyl-GABA) in schizophrenia. | 21 schizophrenic patients were treated in a single blind study with para-chlorphenyl-GABA (baclofen) for 20 days after a placebo period of at least 1 week. Global clinical impression identified five patients as behaviorally unchanged, seven as improved and nine as worsened during the active drug administration. Four pa... | 329,292 | [
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Allergic bronchopulmonary aspergillosis in a cane-sugar mill. | Allergic bronchopulmonary aspergillosis is reported in two (1.5%) of 131 workers occupationally exposed to Aspergillus fumigatus at the U.D. Sugar Mills, Shamli. Twelve of the workers revealed Type I (9.2%) and three (2.8%) Type III skin hypersensitivity against with fungus. Serum preciptins were demonstrated in two ou... | 329,408 | [
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Antibiotic agranulocytosis: association with cephalothin and carbenicillin. | A 65-year-old woman developed agranulocytosis on two separate occasions following prophylactic administration of antibiotics before cardiac surgery. In the first leukopenic episode, large doses of cephalosporin derivatives were the only drugs implicated, and in the second, carbenicillin was believed responsible. Life-t... | 329,421 | [
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Management of ankylosing spondylitis with flurbiprofen or indomethacin. | The effects of flurbiprofen (150-200 mg daily) and indomethacin (75-100 mg daily) were compared in the management of 26 patients with active ankylosing spondylitis in a parallel, double-blind, and randomized trial of six weeks' duration. No patient in either group withdrew from the study because of lack of efficacy of ... | 329,422 | [
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Therapeutic acupuncture: a selective review. | The use and effectiveness of acupuncture has become a major controversy. The limited data on the subject and the wide variety of methods referred to as "therapeutic acupuncture" have added to the confusion. Among physicians who use acupuncture as one modality of treatment, there exist many opinions regarding the defini... | 329,425 | [
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[Botulism in a number of yearlings (author's transl)]. | An outbreak of botulism in four yearlings of a single herd is reported. One animal recovered spontaneously. The other animals underwent euthanasia (animal A) or were slaughtered (animals B and C). Cl. botulinum toxin type C was detected in the sera of animals A and B as well as in the liver and abomasal contents of ani... | 329,471 | [
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Clinical evaluation of a new anthelmintic - C. 9333 Go./CGP 4540 in human hookworm infection. | A new antihookworm compound, C.9333 Go./CGP 4540, was evaluated clinically in 65 adult patients with hookworm infection. Several dosage schedules were evaluated to determine an effective, well tolerated and convenient regime. The lowest effective dose was 125 mg administered at four-hourly intervals for three doses. Th... | 329,490 | [
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[Intensive supervision of labor with the help of the computor (author's transl)]. | A system of supervision which we developed was described. With this system it is possible to make on-line evaluations of the CTG and postpartal blood analyses from the cord blood via computors (AEG 60-10 and AEG 60-50). The computed parameters together with all obstetrical data collected during the pregnancy (results f... | 329,595 | [
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[Investigations made to test the demarcation line method (DLM) after Dienes for its suitability in the epidemiology of Proteus mirabilis (author's transl)]. | In 1946, DIENES observed that non-identical Proteus-strains, when swarming towards each other, were froming distinctly demarcated lines ("DIENES' phenomenon", demarcation (=AGL) phenomenon). Strains of the same origin were amalgamating without demarcation. In 1970, STURDZA studied this phenomenon and commented on its r... | 329,623 | [
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The effect of luteinizing hormone releasing hormone and steroids on the release of LH and FSH from incubated turkey pituitary cells. | The secretion of immunoreactive luteinizing hormone (IR-LH) and follicle stimulating hormone (IR-FSH) by turkey pituitary cell suspensions has been investigated. No significant effects of synthetic ovine luteinizing hormone-releasing hormone (LH-RH) on gonadotrophin release were found with cells from 17 to 19 weeks old... | 329,625 | [
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Current concepts in intrahepatic cholestasis. | The investigations on experimental intrahepatic cholestasis of the last 10 years suggest that any of several different functional alterations may lead to cholestasis. In most studies very high doses of cholestatic compounds have been used. The relevance of these studies to clinical syndroms of cholestasis which usually... | 329,628 | [
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Microbial aggregate contamination of water lines in dental equipment and its control. | Water from some dental clinics has been examined and found to be discoloured, badly tasting and with a foul odour. Moreover, brown or black flakes were often present in tap water, as well as in the water lines of dental equipment. Examination by phase-contrast and electron microscope showed the flakes to consist of agg... | 329,637 | [
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Nutritional effects of salmonellosis in mice. | Mice infected with a standard challenge of Salmonella typhimurium manifest a number of changes associated with endotoxemia. These changes result in profound alterations in the nutritional and metabolic status of the host. Food and water intake approaches levels of total inanition, blood glucose declines more rapidly th... | 329,666 | [
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Overwhelming postsplenectomy infection. | One of the more intriguing aspects of the spleen is the protection against certain bacterial infections afforded by its unique vascular and immune function. There have been extensive clinical surveys which indicate an incidence of overwhelming postsplenectomy infection (OPSI) above that of the disease for which the spl... | 329,670 | [
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Bishop Harmon forceps with tying platform. | A smooth platform added to the Bishop Harmon forceps makes these forceps ideal for tying larger sutures and holding the sclera during detachment surgery. | 329,679 | [
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Construction of a multipolar needle electrode for activation study of the heart. | The study of transmural activation of the intact heart requires placement of multipolar needle electrodes through the wall of the beating heart. This report describes a method developed for constructing lightweight multipolar needles with 10-30 leads mounted 1 mm apart. The electrodes are constructed from readily avail... | 329,690 | [
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The status of immunotherapy in children--what are the problems? | Immunotherapy, widely used in the treatment of atopic disease, poses many problems. In asthma the multiple etiologic factors involved make clinical trials of its efficacy difficult to evaluate and immunological studies are badly needed. Allergen extracts of standard potency are essential. The author feels that practici... | 329,719 | [
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Immunopathologic study of herpes gestationis in mother and infant. | In vivo bound C3 was demonstrated by immunofluorescence in lesions of both maternal and infant skin in an immunopathologic study of herpes gestationis. Immunoglobulins and other complement components of both classical and alternative pathways were not found. The serum was also negative for circulating antibody to basem... | 329,771 | [
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The immunoglobulin-bearing cells in the lamina propria and the clinical response to a gluten-free diet in dermatitis herpetiformis. | In 17 patients with DH, multiple duodenal and jejunal biopsies were performed. In all patients the small-intestinal biopsy-specimens showed histopathological changes compatible with coeliac disease. Fourteen of the patients maintained a gluten-free diet (GFD) for more than 8 months. The small-intestinal lesions improve... | 329,776 | [
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Secondary intention post and core. | Methods for restoring existing crown and bridge restorations to normal function following pulp death are reviewed. Endodontic therapy must be supplemental by a reinforcing post-core system if the crown or bridge is to withstand normal functional loads indefinitely. | 329,822 | [
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Inefficiency of sanitation measures aboard commercial aircraft: environmental pollution and disease. | Recent investigations at Tokyo International Airport have proven that environmental pollution resulting from the inefficient disposal of human excretion aboard aircraft is an important problem from the standpoint of quarantine. It is, therefore, recommended that the worldwide aviation industry take immediate measures t... | 329,830 | [
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Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture. | Glycopyrrolate, a new anticholinergic agent, was evaluated and compared with atropine. Glycopyrrolate 0.2 mg to neostigmine 1.0 mg was found to be safe and effective. The heart rates remained more stable with glycopyrrolate, and the frequency of arrhythmia, which was both transient and of no consequence, was similar in... | 329,848 | [
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0.03343112,
0.0925... |
The detection of granulocyte alloantibodies with an indirect immunofluorescence test. | An indirect immunofluorescence technique for the detection of alloantibodies against granulocytes was developed. A major problem was the unspecific fluorescence of granulocytes, due to unspecific adherence of immunoglobulins to the cell membrane. This could be suppressed by the prefixation of the granulocytes with para... | 329,857 | [
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0... |
[Cinematics of fibroblast spreading. I. Analysis of a population]. | Normal mouse fibroblasts were studied by means of time-lapse microcinematography under phase-contrast microscope. For 31 cells the area measurements during spreading were made with the intervals of 2.5--5 minutes. The following results have been obtained. The maximal area of spreaded cell is 3--4 times greater than the... | 329,893 | [
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-... |
Microbiological relevance and clinical potential of ampicillin-cloxacillin synergism. | Recent demonstration "in vitro" that combinations of ampicillin and cloxacillin, using concentrations at which neither were previously effective, will kill certain resistant Gram negative bacteria, has important clinical potential. We therefore studied 50 ampicillin resistant Gram negative rods cultured from septicemic... | 329,905 | [
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0.4162901,
-... |
[Test-strains of E. coli for detection of chemical mutagens]. | Two temperature-sensitive mutants--AP 16 and AP 18 were isolated after the treatment of E. coli AB2500 strain with two mutagens (acridine orange and 5-bromuracil). The mutants obtained proved to be sensitive and formed revertants when treated with the following agents: N-methyl-N'-nitro-N-nitrosoguanidine, hydroxylamin... | 329,914 | [
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0.06315583,
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... |
Effect of positive end-expiratory pressure on lung mechanics during anaesthesia in dogs. | We studied supine anaesthetized dogs to determine whether the use of positive end-expiratory pressure to increase functional residual capacity (FRC) could thereby prevent the small lung compliance values frequently reported during anaesthesia. We first made control measurements of FRC and of both static (CSTAT) and dyn... | 329,955 | [
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Alkaline gastritis and alkaline esophagitis: a review. | Alkaline gastritis and alkaline esophagitis are now precisely defined syndromes. They occur most often after gastric surgery in which function of the pyloric and lower esophageal sphincter is compromised. Reflux of bile in these patients can then lead to severe inflammation of the gastric and lower esophageal mucosa. E... | 329,967 | [
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Some aspects of the mechanisms by which industrial solvents produce neurotoxic effects. | A Short Review is given of the biochemical neurotoxic mechanisms of common industrial solvents of various structures. The acute effects of organic solvents may be caused by their direct action on the nerve cell membrane and energy metabolism, whereas chronic neurotoxic effects may be explained by the formation of chemi... | 330,013 | [
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... |
Effects of pyrrol-carboxylic acid derivatives on the growth of coliphages. | Effects of 14 pyrrol-carboxylic acid derivatives and analogues (PY-compounds) on the growth of coliphage MS2 using E. coli E102 (Hfr) as the host were measured by the agar double-layer method. Enlargements of plaque size were observed with 7 PY-compounds but increase in plaque numbers was not induced. These enlargement... | 330,014 | [
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Lymphocyte populations in peripheral blood during normal human pregnancy. | The effects of normal pregnancy on peripheral blood lymphocytes were investigated. The frequencies of thymus-derived and bone-marrow-derived lymphocytes in maternal peripheral blood does not vary significantly throughout pregnancy. This observation implies qualitative rather than quantitative alterations in lymphocyte ... | 330,056 | [
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Immunobiology of primary intracranial tumours. II. Analysis of lymphocyte subpopulations in patients with primary brain tumours. | Circulating peripheral blood lymphocyte subpopulations were analysed in patients with primary intracranial neoplasia. Patients with tumours of glial origin demonstrated a significant depletion of E-rosetting lymphocytes whereas the quantitative lymphocyte profiles of patients with non-glial brain tumours were normal. T... | 330,067 | [
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0.3215208,
0.0826755... |
Renal clearance and tissue accumulation of gentamicin. | Multiple-dose studies of gentamicin pharmacokinetics were performed in 2 treated patients. After the final dose, serum and urine concentration declined in biphasic fashion with beta half-lives of 87 and 173 hr. Recovery of the total dose administered required urine collection for at least 10 to 20 days after the last d... | 330,081 | [
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0... |
Oral health status of institutionalized elderly Cape Coloreds from the Cape Peninsula of South Africa. | A study has been conducted to assess the oral health status and need for dental treatment among elderly Cape Coloreds resident in homes for the aged in the Cape Peninsula of South Africa. This paper describes the prevalence of diseases of the mouth with special reference to denture-induced lesions and white lesions of ... | 330,093 | [
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0.7142459,
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0.24505... |
Transfer of episome F'lac+ and chromosomal trp+ genes from Erwinia amylovora to Salmonella typhimurium. | The F'lac+ episome of Escherichia coli origin was transferred by conjugation with frequencies of 10(-7) to 10(-5) from Erwinia amylovora to 14 out of 15 Salmonella typhimurium trp female parents. The chromosomal trp+ genes were transferred with frequencies of 10(-7) to 10(-6) only to one trpB and 2 trpD female parents,... | 330,120 | [
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... |
[Study of gastric secretion in white rats with a chronic gastric fistula on endotoxin exposure]. | The author carried out a study on the stomach secretion in white rats endotoxin shock, induced by venous adminsitration of endotoxin, obtained from Escherichia coli. Stomach fistula was made on the rats in advance and the stomach juice was collected under the condition of chronic experiment. The amount of stomach juice... | 330,148 | [
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Macromolecular synthesis and energy level in a mitochondrial conditional yeast mutant, tsm-8. | Mitochondrial DNA, protein and ATP syntheses persist at non-permissive temperature (35 degrees C) in the mitochondrial, conditionally rho- petites forming yeast mutant, tsm8. Protein and ATP syntheses, however, are diminished during prolonged incubation at 35 degrees C in non-fermentable substrate. Mitochondrial RNA sy... | 330,160 | [
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... |
The primary structure of a non-histone chromosomal protein. | The primary structure of the calf thymus non-histone chromosomal protein HMG-17 has been determined. The sequence was determined mainly from data provided by the peptides obtained by cleavage with staphylococcal protease. Additional information was obtained from peptides produced by cleavage with trypsin and alpha-prot... | 330,164 | [
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A double-blind parallel study of acetylcysteine-isoproterenol and saline-isoproterenol in patients with chronic obstructive lung disease. | A double-blind parallel study in patients with asthma compared the safety and efficacy of saline-isoproterenol (SI) and acetylcysteine-isoproterenol (AI), when administered at home as an aerosol, over a one-week period, using a conventional nebulizer compressor. Measurements of pulmonary function revealed statistically... | 330,289 | [
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Correlation between titer of antibody to hepatitis B core antigen and presence of viral antigens in the liver. | Liver specimens of 31 autopsied cases of liver cirrhosis who had had detectable levels of antibody to hepatitis B core antigen (anti-HBc) inthe serum were stained for hepatitis B core antigen (HBcAg) and hepatitis B surface antigen (HBSAg) by the direct immunofluorescence method. Their premortem serum samples were tes... | 330,306 | [
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... |
Effect of prolonged feeding with chenodeoxycholic acid on bile in patients with and without gallstones. | Nineteen patients who received chenodeoxycholic acid 750 mg/day for six months had duodenal bile aspirated before and after treatment. In five patients with hypertriglyceridaemia but no gallstones cholesterol saturation was reversed in every case, the mean cholesterol saturation index (SI +/- standard deviation) changi... | 330,352 | [
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0.1908261,
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Cytochemical and biological properties of Mycobacterium bovis BCG. | It was the aim of the present communication to find a simple test for a reliable discrimination of Mycobacterium bovis BCG from Mycobacterium tuberculosis. A total of 26 BCG strains, out of them 10 Czechoslovak strains (2 lyophilized cultures of BCG of different batch, 6 strains isolated from abscesses of children afte... | 330,364 | [
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0.4868473,
0.4433357,
0.3112836,
-0.147793,
0.049... |
Antifungal antibiotic of the Basidiomycete Oudemansiella mucida. II. Life cycle and fructification of the producing fungus. | The developmental cycle of the fungus Oudemansiella mucida, the producer of a new antifungal antibiotic, was found to be controlled by the mechanism of homogenic tetrapolar incompatibility; under our conditions, the cycle took about 12 weeks to completion. Optimum conditions for a laboratory-scale fructification were i... | 330,366 | [
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0.163151,
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-... |
Antifungal antibiotic of the Basidiomycete Oudemansiella mucida. III. Nuclei in the hyphae of mono- and dikaryons. | Nuclear ratios were studied in terminal and subterminal cells of various mycelia of the basidiomycete Oudemansiella mucida, the producer of the antifungal antibiotic mucidin (MuciderminR Spofa). The dikaryon, the monokaryon, and the mucidin-producing strain that had been cultivated for a long time under submerged condi... | 330,367 | [
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0.03595927,
... |
Primary structure of protein S13 from the small subunit of escherichia coli ribosomes. | The experimental details which led to the determination of the complete primary structure of protein S13 from the small subunit of Escherichia coli ribosomes are presented. S13 consists of 117 amino acid residues and has the following composition: Asp6, Asn2, Thr6, Ser6, Glu6, Gln2, Pro4, Gly11, Ala11, Cys1, Val7, Met2... | 330,375 | [
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... |
Enhanced susceptibility of mice to combinations of delta 9-tetrahydrocannabinol and live or killed gram-negative bacteria. | Combinations of delta 9-tetrahydrocannabinol (delta 9-THC) and bacterial endotoxin were shown to be hyperadditively toxic for mice. A variety of purified lipopolysaccharide (LPS) preparations elicted enhanced mortality in combination with delta 9-THC. Escherichia coli O26:B6 LPS (Boivin preparation) at an essentially n... | 330,405 | [
0.06395616,
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0.2909783,
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-... |
Local immune response to lipoprotein of the outer membrane of Escherichia coli in experimental pyelonephritis. | The local immune response to the lipoprotein of the outer membrane of Escherichia coli O6:K13:H1 was determined in experimental hematogenous pyelonephritis in rabbits. Local antibody was analyzed with the enzyme-linked immunosorbent assay on newly synthesized protein from kidney. Local or intrarenal antibody was detect... | 330,406 | [
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0.1840859,
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Fine-structure mapping of the firA gene, a locus involved in the phenotypic expression of rifampin resistance in Escherichia. | The firA (Ts)200 mutation not only eliminates the resistance to rifampin of certain genetically resistant strains, but, moreover, renders ribonucleic acid synthesis thermolabile. The firA gene has been mapped by P1 tranduction and is located extremely close to the structural gene for deoxyribonucleic acid polymerase II... | 330,494 | [
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0... |
Intracellular localization of the superoxide dismutases of Escherichia coli: a reevaluation. | All of the superoxide dismutase isozymes of Escherichia coli have been shown to occur in the cell matrix, and none have been found in the periplasm. This was the case with both E. coli B and E. coli K-12, whether grown on a low phosphate medium or on a Trypticase soy-yeast extract medium. Alkaline phosphatase was used ... | 330,499 | [
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-... |
Isolation, genetic analysis, and characterization of Escherichia coli mutants with defects in the lacY gene. | Five hundred thirty-five lacY mutants were isolated from an Escherichia coli strain carrying the lactose operon on an F' factor, either without mutagenesis or after mutagenesis with 2-aminopurine or N-methyl-N'-nitro-N-nitrosoguanidine. Crosses against 48 independently isolated deletions ending in the lacY gene divided... | 330,501 | [
0.1855767,
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0.08508572,
0.2384961,
0.2997466,
-0.2467894,
-0.2284241,
-0.1474808,
0.3534482,
-0.3435319,
0.1520258,
0.01358903,
0.1103143,
0.3034765,
-0.2280033,
0.1249066,
-0.2433781,
-0.2034955,
-0.05693166,
0.06426334,
0.5654691,
0.1075184,
-0.2161999,
0.0... |
Relationship between messenger ribonucleic acid and enzyme levels specified by the leucine operon of Escherichia coli K-12. | The levels of leucine-forming enzymes in Escherichia coli K-12 varied over a several thousand-fold range, depending upon conditions of growth. The highest levels were achieved by growing auxotrophs in a chemostat under conditions of leucine limitation. Under such conditions, enzyme levels were increased 45- to 90-fold ... | 330,509 | [
-0.3519142,
-0.2378342,
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0.2186362,
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0.2192392,
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0.3077428,
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0.3804244,
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0.2440791,
0.1865413,
0.3952596,
0.6234918,
0.009587165,
-0.03015998... |
Escherichia coli protein X is the recA gene product. | Escherichia coli protein X is known to be made in large amounts following DNA damage or inhibition of DNA replication. We have shown that it is identical to the recA gene product by partial proteolytic digestion of the radiochemically pure proteins and analysis by electrophoresis on polyacrylamide-sodium dodecyl sulfat... | 330,525 | [
-0.1420776,
0.02155882,
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0.01491415,
0.01448519,
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0.2604347,
0.1912955,
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0.02630392,
-0.07609093,
0.1420395,
0.3464485,
-0.02580035,
-0.150... |
Analysis of the structure of T4 bacteriophage-modified valyl-tRNA synthetase by limited proteolysis and isoelectric focusing. | The new form of valyl-tRNA synthetase (EC 6.1.1.9) that appears immediately after infection of Escherichia coli with bacteriophage T4 was purified and subjected to mild proteolysis using five different proteases. The inactivation of aminoacylation activity was both more extensive and rapid than that obtained with valyl... | 330,535 | [
0.06325532,
0.1997655,
-0.3288094,
0.01490938,
0.126056,
-0.5139527,
0.2055468,
0.006063845,
0.1259,
0.2675804,
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0.07721877,
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0.0468966,
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0.3485321,
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0.2054422,
-0.08808867,
0.4122185,
0.1678279,
0.192974,
-0.186015,
-0.02417749... |
Bonding mechanism evidence in a ceramic--nonprecious alloy system. | Bonding between porcelain and dental ceramic alloys is thought to be dependent upon the establishment of a continuous electron structure across the ceramic-metal interface (Pask, Proc. Porcelain Enamel Inst.,33,1,1971). Such a structure most likely results from the compatibility of metal ions at the metal surface satur... | 330,539 | [
0.006127482,
0.6065236,
0.128233,
0.294678,
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0.2202396,
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0.2339784,
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0.0006349276,
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0.163875,
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0.1214904,
0.5277267,
0.02121408,
0.03721541,
-0.1... |
Relationship of K1 antigen to biotype in clinical isolates of Escherichia coli. | Two hundred and ninety-four isolates of Escherichia coli, including 105 from blood cultures, 94 from stools of hospital inpatients, and 96 from rectal cultures of healthy young adults, were biotyped by using the API-20E system and tested for the presence of K1 antigen. The overall frequency of K1 strains was 14.2% and ... | 330,559 | [
-0.2478043,
-0.09739571,
0.0118,
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0.04222526,
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0.2469045,
0.1515487,
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0.1403152,
0.1403508,
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0.2491077,
0.08076084,
-0.18081,
... |
Circulating immune complexes after renal transplantation. Correlation of increased 125I-Clq binding activity with acute rejection characterized by fibrin deposition in the kidney. | To assess the role of circulating immune complexes in the pathogenesis of acute rejection, sera were measured for such complexes by the (125)I-C1(q) binding assay in 45 normal subjects, 24 allografted patients undergoing acute rejection, and in 11 allografted patients in a quiescent phase. Increased C1(q)-binding activ... | 330,564 | [
-0.06877472,
0.1334936,
0.01976201,
0.1225158,
0.1073321,
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0.2174035,
0.02619601,
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0.0733094,
0.03000692,
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0.1720302,
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0.02191896,
0.3393257,
0.5124639,
0.2061618,
-0.2856829,
... |
A role for prostaglandin E in defective insulin secretion and carbohydrate intolerance in diabetes mellitus. | Prostaglandin E(2) (PGE(2)) infusion in normal humans inhibited acute insulin responses to a glucose (5 g i.v.) pulse (response before PGE(2) = 593 +/- 104%; during PGE(2) = 312+/-55%; mean+/-SE, mean change 3-5 min insulin,% basal, P < 0.005). This effect was associated with a decrease in glucose disappearance rate... | 330,566 | [
-0.1117482,
0.02838414,
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0.1073021,
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0.2217908,
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0.04429245,
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0.0804667,
0.187542,
0.03865477,
0.4878638,
0.02759006,
0.2608184,
0.01577521,
... |
Recurring digital fibrous tumor of childhood. | A case of digital fibrous tumor of childhood is described. This tumor is multicentric, of possible viral origin, and is characterized histologically by intracytoplasmic inclusion bodies within proliferating fibroblasts. The tumor recurred despite wide local excision and skin grafting. | 330,613 | [
-0.4239843,
0.190229,
-0.2700322,
-0.2081582,
0.1822359,
-0.4747957,
-0.3992924,
0.171769,
0.04351861,
0.2251174,
0.2488162,
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0.1232376,
-0.2537526,
0.109785,
0.2497049,
-0.4011908,
... |
Translocations in the mosquito, Culex tritaeniorhynchus. | Fifty-eight translocations were produced and studied using improved genetic and cytogenetic techniques now available for Culex tritaeniorhynchus. Data confirm previous chromosome-linkage correlation studies and indicated that the e locus is on the long arm (2R) of chromosome 2. | 330,619 | [
0.03389875,
0.1402068,
0.1064505,
-0.116921,
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-0.178553,
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0.05753876,
0.2695979,
0.2834294,
0.2504481,
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0.04981893,
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0.06117115,
0.09038107,
0.179363,
0.2053722,
-0.003854861,
-0.07301088,... |
Imaging systems for correlation of false alarms in flow. | False alarms, arising from a variety of sources, are the greatest remaining obstacle to development of an automated prescreening system for gynecologic cytology. This paper describes two correlation systems under development at the University of Rochester and discusses their utilization in the study of false alarms in ... | 330,736 | [
-0.03310516,
0.03909566,
-0.2819069,
0.02221302,
0.08594768,
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0.007386432,
0.5648659,
0.1607852,
0.01672251,
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0.07384787,
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-0.09129551,
-0.03177357,
0.2233995,
-0.1900783,
0.3469264,
-0.1451642,
-0.195634... |
Immunosuppression by spleen cells from Moloney leukemia. III. Evidence for a suppressor cell that is not the leukemic, virus-producing cell. | Spleens of mice bearing MuLV (Moloney)-induced leukemia contain cells that inhibit the antibody response of normal syngeneic lymphocytes to sheep RBC in Marbrook cultures. In order to determine whether these immunosuppressive cells are virus-infected tumor cells or normal cells we pretreated leukemic spleen cell suspen... | 330,747 | [
-0.06014566,
-0.05908342,
-0.1687844,
-0.331199,
0.4157384,
0.1325098,
0.03498106,
0.1160796,
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0.2337501,
0.2050928,
0.3887905,
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-0.09583285,
-0.1109352,
0.006755114,
0.5492196,
0.1466419,
0.0851579,
-0.1727147,
... |
Relative enterotoxigenicity of coliform bacteria. | The enterotoxigenicity of 12 strains of coliform bacteria (Enterobacter cloacae, Klebsiella pneumoniae, and Escherichia coli) isolated from the gastrointestinal (GI) tract of persons with either acute diarrhea or tropical sprue and of 13 strains of the same species isolated from urine (GU) cultures was determined. Frac... | 330,767 | [
-0.07456688,
-0.127095,
-0.05285585,
0.005631918,
0.07943428,
-0.1171504,
-0.1892061,
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0.006171097,
0.1075593,
0.04344863,
0.04818653,
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0.07375142,
0.02010655,
0.008607055,
-0.0360852,
0.1471404,
0.168... |
Phytohemagglutinin-induced differentiation and blastogenesis of precursor T cells from mouse bone marrow. | The cells in mouse bone marrow (BM) capable of responding to phytohemagglutinin (PHA) were shown to be precursor T cells in experiments employing athymic mice, immunofluorescence, and specific lysis of T or B cells with cytotoxic antisera + complement. In contrast, the responses of lymph node (LN) and spleen (Spl) cell... | 330,790 | [
0.206158,
-0.3069524,
-0.1358587,
-0.1929772,
0.1281043,
-0.2518014,
-0.01623037,
0.120411,
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0.1921089,
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0.3196523,
0.08297809,
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0.5054143,
0.3078879,
0.04809093,
-0.1232853,
... |
The effect of a drug-resistance factor on recombination and repair of DNA in Escherichia coli K12. | The presence in recipient strains of Escherichia coli K12 of the plasmid R46 greatly reduced the yield of recombinants from crosses with several Hfr strains and virtually abolished the formation of recombinants by PI transduction without, however, significantly affecting the transfer of the F prime from a strain carryi... | 330,823 | [
-0.2660791,
-0.2914059,
-0.08613543,
-0.2059498,
0.3119211,
-0.358874,
0.04679109,
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0.1516008,
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0.2496028,
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0.1545416,
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0.04049432,
-0.02699562,
-0.4441793,
0.2269158,
0.07051776,
0.02923634,
-0.3029196... |
Construction of a post and core to fit a completed restoration. | A simple technique to fabricate a post and core to fit a completed restoration is described. This technique saves the time and effort of remaking the restoration when endodontic treatment and reinforcement of the tooth are required after construction of the restoration. | 330,848 | [
-0.2684145,
0.7551636,
-0.3001454,
0.2297913,
-0.1248435,
-0.1302069,
-0.05868024,
0.1883932,
0.2078255,
0.08442573,
0.03355618,
0.1052328,
0.04667301,
0.08113982,
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0.05220971,
-0.5715635,
-0.186794,
0.0144643,
0.2425696,
0.06357364,
... |
In vitro packaging of UV radiation-damaged DNA from bacteriophage T7. | When DNA from bacteriophage T7 is irradiated with UV light, the efficiency with which this DNA can be packaged in vitro to form viable phage particles is reduced. A comparison between irradiated DNA packaged in vitro and irradiated intact phage particles shows almost identical survival as a function of UV dose when Esc... | 330,877 | [
-0.1097583,
-0.08606389,
-0.265853,
0.06911607,
0.06259245,
-0.3144335,
0.02514473,
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0.1659916,
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0.2907463,
0.09417839,
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0.1943947,
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0.2031479,
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-0.06431618,
0.1453604,
0.1606221,
0.2420156,
0.1026025,
-0.2129101,
... |
Felty's syndrome: an analytical review. | The clinical and laboratory features of 72 patients with Felty's syndrome described within the last ten years have been compared with Felty's five original patients. Felty's syndrome appears to be a variant of rheumatoid arthritis with extra-articular manifestations in which leukopenia (usually due to neutropenia) and ... | 330,914 | [
0.05596549,
-0.2973597,
-0.119869,
-0.01251281,
-0.03599514,
0.06160812,
0.145721,
0.002185242,
0.09656779,
0.1105851,
0.1947522,
0.01430951,
0.04272006,
-0.2446577,
-0.1912299,
-0.06773134,
-0.003497809,
-0.1111365,
-0.1824726,
0.2386013,
0.04597754,
0.01416927,
0.210922... |
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