title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Platelet transfusion therapy. | Platelet transfusions are of unquestionably proven benefit for the correction of thrombocytopenia or functional platelet disorders, and they have allowed for more intensive antineoplastic therapy. With the advent of blood component therapy most modern blood banks now have the capabilities for supplying at least limited... | 330,975 | [
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Radiation scattering and the determination of regional cerebral blood flow by radioisotope clearance. | The sources of error involved in the measurement of regional cerebral blood flow (rCBF) with radioactive tracers in man have been studied. This report shows that one of the main sources is the weakness of the energy emitted by the tracers used. Clearance curves obtained with scalp detectors are subject to interference:... | 331,067 | [
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The regulation of RNA synthesis in yeast. I: Starvation experiments. | The synthesis of tRNA in yeast is shown to be under separate control to that of rRNA during amino acid and nitrogen starvation. Inhibitors of the elongation and termination steps of protein synthesis were found to stimulate the synthesis of tRNA in starved yeast cells. This effect appeared to be due to the "trickle-cha... | 331,081 | [
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[Hereditary fructose intolerance (author's transl)]. | Hereditary fructose intolerance (HFI) is the most important disturbance in human fructose metabolism. This paper deals with the present knowledge of biochemistry and pathophysiology of this inborn error of metabolism, which is often wrongly diagnosed and gives a detailed description of diagnostic and therapeutic proced... | 331,087 | [
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Conditional lethal mutants of bacteriophage T4 unable to grow on a streptomycin resistant mutant of Escherichia coli. | Sixteen conditional lethal mutants of bacteriophage T4D have been isolated which grow on Escherichia coli CR63 (a su+ streptomycin-sensitive K12 strain) but are restricted by CR/s (a streptomycin-resistant derivative of CR63). These mutants have been given the prefix str. Four of these mutants are amber and 12 appear t... | 331,100 | [
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[Combined immunological and cytochemical identification of nucleated cells in normal human peripheral blood]. | Nucleated cells obtained from normal human peripheral blood on a layer of Ficoll Isopaque are identified according to the combination of various assays: phagocytosis, endogenous peroxidase, naphtol AS-D esterase, immunofluorescence (IF) performed at 4 degrees C and after incubation at 37 degrees C. The Ig bearing lymph... | 331,248 | [
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Analogs of methionyl-tRNA synthetase substrates containing photolabile groups. | Three photolabile analogs of substrates of methionyl-tRNA synthetase were synthesized. In one, the 4-thiouridine at the 8 position of E. coli tRNAfMet was alkylated with [14C]p-azidobromoacetanilide. In the second, [14C]p-azidobenzoic acid hydrazide was condensed with the 3'-terminal dialdehyde of periodate-oxidized Es... | 331,263 | [
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Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. | The distribution of Met-enkephalin- and substance P-immunoreactive neurons was studied by indirect immunofluorescence in some areas related to pain and analgesia. Met-enkephalin- and substance P-positive cell bodies and nerve terminals were observed in the periaqueductal central gray, the nucleus raphe magnus, the marg... | 331,326 | [
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The use of a fascial flap in ear reconstruction. | We describe the use of a fascial flap for covering the framework in ear reconstruction. When covered in turn with a skin graft, this fascial flap provides an abundant amount of a thin, tough, vascular, hairless cover of good quality in all cases except those where injuries in the auricular area have been deep enough to... | 331,370 | [
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The surgical treatment of necrobiosis lipoidica diabeticorum. | We review the literature on the surgical treatment of necrobiosis lipoidica diabeticorum, and we describe 7 cases treated at Stanford University Medical Center. Experiences with them prompt us to recommend surgical excision of the lesions down to the deep fascia, ligation of the associated perforating blood vessels, an... | 331,372 | [
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Rational use of hepatitis B immune globulin. | A review is given of present experiences of hepatitis B prevention through the use of immune globulins containing high titres of antibodies to hepatitis B surface antigen. This type of passive immunization has proved effective after accidental exposure to contaminated material in hospitals and for regular prophylaxis a... | 331,461 | [
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A gastroscopic and histological double-blind study of the effects of diclofenac sodium and naproxen on the human gastric mucosa. | The effects of diclofenac sodium and naproxen on the gastric mucosa were studied in a double-blind trial by gastroscopy, gastrophotography and histological examination of the mucosa in six healthy volunteers. Detectable lesions were evident in the mucosa of four subjects after administration of both drugs, and the lesi... | 331,465 | [
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[Activation of the complement system in different forms of glomerulonephritis]. | The complement system may be activated by two pathways, the classical and the alternate. To evaluate their respective participation in different forms of glomerulonephritis, the plasma values of C3, C4, C3PA, C1q and properdin were determined in 70 patients. In systemic lupus erythematosus (LED), acute poststreptococca... | 331,469 | [
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Immune response in the sea urchin Lytechinus pictus. | The sea urchin shows an immune response to grafted tissue similar to that found in vertebrates. Unrelated animals rejected allografts in about 30 days. Acceptance of allografts was observed for tissue exchanged between some F2 and F3 inbred animals. The percentage of acceptances reflected the degree of inbreeding. Acc... | 331,476 | [
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Clinical trial of tolmetin and aspirin in the treatment of rheumatoid arthritis. | A double-blind crossover, within-patient trial was conducted, to compare the efficacy of tolmetin (Tolectin; Ethnor) with that of aspirin in the treatment of rheumatoid arthritis. Tolmetin significantly improved morning stiffness (P less than 0.01), while aspirin was superior in reducing the number of painful joints (P... | 331,504 | [
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[Influence of radiation-induced electrolytic shifts upon the metabolism: VII. On the question of equivalence of K+-loss and Na+-uptake (author's transl)]. | Irradiated and nonirradiated yeast cells in three different metabolic conditions were incubated with four different culture mediums at various K+/Na+-concentrations and with or without glucose. The losses of K+ and the incorporation of Na+ are analysed after five hours and represented as balance values. Equivalent shif... | 331,560 | [
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The management of special problems associated with Stevens-Johnson syndrome and ocular pemphigoid. | Various surgical treatment methods were outlined that are currently used in treatment of the severe chronic contractual changes seen in Stevens-Johnson syndrome and ocular pemphigoid. All methods described are not 100% successful in view of the chronicity of the disease, but have greatly aided in delaying the destructi... | 331,631 | [
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[Histopathomorphologic changes in the organs and tissues of laboratory animals receiving an artificial diet with a low selenium and vitamin E content]. | The deficiency of selenium and vitamin "E" is not infrequently noted to occur in agricultural and game-animals. Its development in humans is not ruled out. Experiments set up on mice of the CC57 lineage fed on an artificial ration with a low selenium and vitamin "E" content showed an acute selenium and vitamin "E" defi... | 331,676 | [
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[Treatment of rheumatoid arthritis with the immunosuppresive agent, prorezid]. | Prorezid treatment was applied to 30 patients with rheumatoid arthritis. It was applied per os with a daily dose of 300 mg to 12 subjects; to 18-intravenous drop infusion with 5 per cent serum glucose--daily dose 400 mg. Oral administration total dose-7-8 g; infusion-10-12 g. Drop infusion administration proved to be m... | 331,687 | [
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Inquests into London and Middlesex homicides, 1673-1782. | Depositions for coroners' inquests on 377 deaths, nearly all of them homicides, were reviewed and analyzed for reported causes and circumstances of death. The role of coroner and surgeon and the emergence of the medicolegal autopsy are considered. | 331,696 | [
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The role of paracellular pathways in isotonic fluid transport. | Paracellular pathways across "leaky" epithelia are the major route for transepithelial ionic diffusion. The permselective properties of these pathways suggest that they offer a watery environment through which ions diffuse in their hydrated forms. There is also suggestive evidence that, at least in some tissues, parace... | 331,697 | [
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[Unitemporary surgical procedure by Michalowski for strictures of perineal and bulbar urethra]. | Initially the authors briefly deal with the genesis of strictures of the urethra in the perineal and bulbar region of the urethra and the experiences and results of the authors with the unitemporary method of operation after Michalowski for these strictures of the urethra are reported. The technique of the plastic-surg... | 331,744 | [
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[Phage conversion of escherichia and shigella antigens. I. Phage conversion of type I antigen of Sh. flexneri in entrophatogenic E. coli O129]. | The authors realized conversion of type I Sh. flexneri in enteropathogenic E. coli O129 with converting moderate phage phi I Sh. flexneri. Phage phi I lysogenized 7.3--42.7% of the cells of antigenic E. coli variant O129 which lost type V antigen; conversion of the type I antigen of Sh. flexneri was revealed in the agg... | 331,793 | [
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Oxprenolol in the treatment of migraine. | Thirty migraine patients received oxprenolol (Trasicor), which is an adrenergic beta-receptor blocking agent with weak beta-stimulating intrinsic activity. The dosage was 80 mg three times a day. The treatment was given by a double blind cross-over technique in which the effect was compared with placebo. Each compound ... | 331,835 | [
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Localization of organ-specific antigens in the nervous system of the rat. | Localization of organ-specific brain antigens in the central nervous system of the rat has been studied by means of indirect immunofluorescence. Rabbit antiserum against homogenate of rat brain, previously absorbed with normal serum and homogenates of rat organs (kidney, liver, spleen), reacted with the water-soluble a... | 331,840 | [
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Mycotic growth and soft denture lining materials. | Mycotic flora was studied from the dentures and denture bearing mucosae of 39 persons who wore soft-lined (Molloplast B) mandibular dentures and heat-cured acrylic resin maxillary dentures. Fungal growth was detected in 85% of the mandibular dentures and in 44% of the maxillary dentures (p less than 0.001). On the mand... | 331,850 | [
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Effects of 1.25-dihydroxycholecalciferol, parathormone and Ca2+ on the pancreatic B-cell sensitivity to alloxan. | The sensitivity to alloxan was investigated by blood and urine glucose determination and light and electron microscopic study of the endocrine pancreas in groups of mice differing from each other with respect to food ingestion and treatment before alloxan administration. Because of differences in occurrence of glucosur... | 331,860 | [
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Origin of intestinal beta-glucuronidase in germfree, monocontaminated and conventional rats. | The intestinal beta-glucoronidase was studied in germfree, monocontaminated and conventional rats. The greater part of the beta-glucuronidase of the caecum and the large intestine of the contaminated animals was of bacterial origin. No bacterial beta-glucuronidase was found in the small intestine. Monocontamination wit... | 331,863 | [
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0.05785181,
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0... |
Prognostic value of angiography in early failure of renal transplants. | The angiographic findings in 18 patients with irreversible rejection and in 20 patients who regained satisfactory renal function were compared. In 13 of the 18 patients who lost their transplants the outcome was predictable from the angiographic appearances. The diagnosis of irreversibility was more accurate in patient... | 331,878 | [
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The management of renal osteodystrophy. | Hyperparathyroidism is the main cause of renal bone disease. At the moment its progress can be retarded by controlling plasma calcium and phosphate. But the prevention and cure of hyperparathyroidism without surgery eludes us. There is a suggestion that the administration of some metabolite of Vitamin D may be more suc... | 331,902 | [
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Toxic chemical agents as probes for permeation systems of the red blood cell. | Chemical agents with different capacities to penetrate into the membrane and with different chemical reactivities can be used to gain information concerning the location of transport sites in the membrane structure and the particular functional ligands. If the agents are highly specific in their interactions and if the... | 331,905 | [
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Drug therapy reviews: management of the disulfiram-alcohol reaction. | A review of the proposed mechanisms of the disulfiram-alcohol interaction and recommended management of the interaction is presented. The efficacy of disulfiram in the management of alcoholism, the signs and symptoms of the disulfiram-alcohol interaction, and other agents with disulfiram-like activity are discussed. Re... | 331,944 | [
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A double-blind short-term trial of guanethidine 3% and adrenaline 0.5% combined in one eye drop. | A double-blind short-term trial was done to test the effect of guanethidine 3% - adrenaline 0.5% (G-A) in a combined eye drop in 18 patients with open-angle glaucoma and one patient with narrow-angle glaucoma. In 9 of the 19 patients we expected an IOP lowering agent. There was one false-negative result. The mean fall ... | 331,994 | [
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Cytophysiological studies on isolated pancreatic islets in vitro. | Single, isolated pancreatic islets of mice and rats were incubated for varying time intervals (0.5-60) minutes with high (300 mg%) and low (50 mg%) levels of glucose. The structural integrity of islets decreased progressively with time regardless of glucose concentration. Degeneration of islets was greatest after 60 mi... | 332,011 | [
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[Memories and reflexions of a psychiatrist of former times]. | After 64 years as a psychiatrist, the author relates his experiences in psychiatric centers and in official practice as an expert. In this way, he comments on the evolution of psychiatry spanning three quarters of a century. In particular, he recalls the various methods of treatment used successively, their success and... | 332,026 | [
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[Survival of microorganisms frozen on solid medium (author's transl)]. | Different freezing methods have been studied for 12 microorganisms. This study has been carried out on solid support in the conditions near the freezing of foods. The survival rates are on relation with species and freezing methods. The survival of some microorganisms during a storage at -20 degrees C has been studied. | 332,029 | [
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Effect of the alteration of gonadal feed-back on LH and FSH release in men. | To observe the influence of gonadal feed-back on FSH and LH release in men we studied the blood levels of both gonadotropins before and after orchiectomy in eight subjects. In four orchiectomized subjects the LH and FSH release induced by LH-RH was also studied. The LH-RH was also administered in eight patients with pr... | 332,052 | [
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Rembrandt's anatomy of Dr. Nicolaas Tulp. | The bye-laws of the Amsterdam Barber-Surgeon's Guild in the 17th century are mentioned and the rules for instruction in anatomy are discussed. The picture of the lesson given by Dr. Nicolaas Tulp and painted by Rembrandt in 1632 is explained and the accusation of an anatomical mistake is disposed of. Some details of th... | 332,088 | [
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[Value of the antiglobulin test and indirect immunofluorescence test in the serological diagnosis of bovine brucellosis]. | In investigations of 5881 sera from brucella infected herds and 8635 sera from negative herds the antiglobulin test (AgT) because of its high susceptibility was shown to be a valuable method in early diagnosis of brucellosis and clearing of non-specific LA-reactions. However, all infected animals are not detected with ... | 332,110 | [
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Fixation-induced cyst-like spaced in the brains of rabbit foetuses. | During teratologic trials, routine investigations of 4261 brains from rabbit foetuses, fixed in Bouin's solution and sectioned by Wilson's free-hand razor blade technique, revealed cyst-like spaces in the brains of 164 foetuses (3.8%). The cyst-like spaces, characterised by the absence of an epithelial or endothelial l... | 332,115 | [
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Carcinogenicity of trichloroethylene: fact or artifact? | Technical trichloroethylene has been found carcinogenic in mice after high daily doses per os. A GC-MS analysis of this technical sample revealed the presence of considerable amounts of epichlorohydrin and 1.2-epoxibutane as stabilizers. These epoxides are highly mutagenic in the Ames test and are, most probably, respo... | 332,116 | [
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[Submicroscopic analysis of the microcirculatory system of the pancreas in several vertebrates]. | The metabolic link of the microcirculatory system of the exocrinous part of the pancreas studied electron microscopically in the frog, chicken and rat has a general plan of the structure. It consists of capillaries, pericapillary gap and intercellular clefts of glandular cells connected with it. But in the frog and chi... | 332,118 | [
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... |
[Express method of histological processing of trephined bone marrow]. | A method for histological treatment of the trephined bone marrow is suggested; it makes it possible to simplify the manipulation and to shorten the time of treatment of biopsy material by more than 24 hours, thereby enabling the investigator to give the conclusion about the state of the medullar hemopoiesis on the same... | 332,127 | [
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[Creutzfeldt-Jakob disease; clinical, histopathological and electron microscopy study of a case]. | The case of a patient 53 years old that had a picture of cortical impairment and pyramidal disfunction, leading in 6 months to acinetic mutism is reported. The histopathology lead to the diagnostic of Creutzeldt-Jakob disease, with neuronal loss, gliosis and status spongiosus. The electron-microscopic examination showe... | 332,131 | [
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Late spontaneous clearing of corneal grafts. | Three cases of graft rejection or primary donor failure after penetrating keratoplasty failed to respond to treatment. After cessation of therapy, these edematous corneas all cleared spontaneously in six to 17 months with the return of excellent vision. It is suggested that repeated keratoplasty be delayed up to 18 mon... | 332,132 | [
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0.0565993... |
[The comparison of binaural balance-tests (author's transl)]. | 14 normal-hearing persons were examined in 7 different versions of the balance-test. Thereby a severe dependence to the methods was found out, caused by psychological factors. By randomization of the side and the intensity (computer-controlled test-procedure) no case showed a significant recruitment. In 23 persons with... | 332,134 | [
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0.1277823,
... |
Improved pepsin inhibitor derived from activation peptide 1-16 of porcine pepsinogen. | The peptide Leu-Val-Lys-Val-Pro-Leu-Val-Arg-Lys-Lys-Ser-Leu-Arg-Gln-Asn-Leu, a known pepsin inhibitor, is derived from the first 16 amino acids of porcine pepsinogen. It was prepared from the activation mixture and was modified by guanidination of its three lysine residues to form homoarginine residues. The modified pe... | 332,223 | [
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Nonenzymatic reduction of prostaglandin H by lipoic acid. | Lipoic acid has recently been found to stimulate prostaglandin biosynthesis by sheep vesicular gland microsomes (Marnett, L. J., and Wilcox, C. L. (1977). Biochim. Biophys. Acta 487, 222). The increase in oxygenated products is predominantly in the formation of prostaglandin F and its structure has been verified by gas... | 332,228 | [
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[Technical and experimental study of two electronic spirometers (author's transl)]. | Two electronic spirometers which use standard pneumotachographs were evaluated for their static and dynamic response, and clinically compared in 20 subjects to a reference flow channel. In the Pneumoscreen the data are digitalized and stored, permitting to play back the flow-volume curves at low or high speed. The inst... | 332,264 | [
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Consequences of acute myelogenous leukemia in early pregnancy. | Cytarabine and thioguanine therapy for acute myelomonocytic leukemia initiated in the tenth week of pregnancy (with the addition of vincristine and rubidomycin at 17 weeks) led to a short complete remission of the leukemia in a 24-year-old primigravida. This is the first case to be reported in which cytarabine was admi... | 332,324 | [
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Combination therapy for diffuse histiocytic lymphoma that includes antimetabolites. | Thirty patients with diffuse histiocytic lymphoma (DHL) were treated with one of three regimens that included cyclophosphamide, vincristine, methotrexate with citrovorum factor rescue, and cytosine arabinoside. Twelve patients had a complete response with a predicted 50% survival of at least 76 months. The medium survi... | 332,346 | [
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Combined modality therapy in malignant lymphomas. | The treatment of patients with non-Hodgkin's lymphomas remains controversial. The Rappaport classification system has established its clinical value in distinguishing relatively favorable disease (ie, nodular or follicular lymphoma) from relatively unfavorable disease (ie, diffuse lymphoma). Despite the problems of mul... | 332,354 | [
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0.2217993,
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Morphologic observations in biologic conduits between aorta and coronary artery. | This report describes morphologic observations in autogenous saphenous veins, autogenous internal mammary arteries, radial arteries and arterial heterografts used as aortocoronary bypass conduits. The normal or expected changes and the abnormal or unexpected changes observed in each type of bypass conduit is discussed.... | 332,366 | [
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... |
Medical vs. urgent surgical therapy for acute coronary insufficiency: a randomized study. | Forty-two patients with acute coronary insufficiency (high risk subgroup) were randomly assigned to urgent coronary bypass surgery or to initial medical therapy followed by elective coronary bypass at four months if indicated at that time for relief of incapacitation angina pectoris. Coronary bypass performed on an urg... | 332,370 | [
0.03688378,
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Cytoplasmic microtubules in transformed mouse x nontransformed human cell hybrids: correlation with in vitro growth. | Patterns of cytoplasmic microtubules in somatic cell hybrids between transformed mouse cells and nontransformed human skin fibroblasts were examined using antitubulin antibodies as an immunofluorescent probe. Nontransformed cells have been shown to exhibit an extensive cytoplasmic microtubule complex (CMTC), while in t... | 332,382 | [
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Apolipoprotein B retention in the grossly normal and atherosclerotic human aorta. | Apoliporotein B (apoB) was measured in buffer-extracted homogenates of grossly normal and artherosclerotic human aortic intima by means of an electroimmunoassay procedure. The apoB values which were expressed as microgram per mg tissue dry weight, varied widely, ranging from 0.34 to 18.45 in normal intima and from 0.8 ... | 332,407 | [
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0.2285563,
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0.3857887,
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-0.5286534,
-0.119153,
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0.3055305,
0.009122185,
0.2066904,
-0.1501539... |
Immunological dissection of rat pregnancy: study of the mode of action of antisera to luteinizing hormone. | The sensitivity of rat pregnancy to luteinizing hormone (LH) depletion on days 7--12 (day 1 = day of insemination) was investigated by intraperitoneal administration of a single injection of various doses of an anti-bovine LH rabbit serum on the day in question. Day 11 was found to be the most susceptible time for this... | 332,421 | [
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0.238681,
0.3366141,
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0.2138... |
Metabolic interrelationships between arsenic and selenium. | In 1938, Moxon discovered that arsenic protected against selenium toxicity. Since that time it has been shown that this protective effect of arsenic against selenium poisoning can be demonstrated in many different animal species under a wide variety of conditions. Antagonistic effects between arsenic and selenium have ... | 332,496 | [
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... |
Glucose and 3-O-methylglucose protection against alloxan poisoning of pancreatic alpha and beta cells. | Alloxan infused into the isolated perfused rat pancreas caused transient insulin secretion release. Alloxan poisoning also prevented subsequent induction of glucose-mediated unsulin release and also prevented the inhibition of glucagon release by glucose. Glucose or 3-O-methylglucose infused simultaneously with alloxan... | 332,568 | [
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Study of gastric emptying using a ferromagnetic tracer. | A new ferromagnetic method for the measurement of gastric emptying is described. An inert tracer, magnesium ferrite, is added to a test meal. Its amount in the stomach is then measured at regular intervals by an external transducer using its ferromagnetic properties. The method is noninvasive and devoid of radiation ex... | 332,577 | [
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[Treatment of hyperuricemia using daily doses of 50 and 25mg of benzbromarone]. | By treating 16 hyperuricemic patients each with 25 and 50 mg of Benzbromarone a significant decrease of the uric acid concentration in the serum into the normal range is achieved. On the 5th and 6th day after beginning the treatment the dosage of 25 mg of Benzbromarone renders a morning value of 5,3 +/- 1,0 and an even... | 332,605 | [
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0.092... |
Canine migration inhibitory factor: effect of Corynebacterium parvum administration. | Peripheral blood lymphocytes from dogs sensitized to streptolysin O (SLO) were assayed for migration inhibitory factor (MIF) production by the indirect MIF test, using guinea pig peritoneal exudate cells as the source of macrophages. A specific direct correlation was established between the degree of inhibition of migr... | 332,636 | [
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0.6144705,
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0.2661537,
0.154294... |
Colloidal iron binding to the surface of HeLa cells, spreading in monolayer culture. | We have used the colloidal iron (CI) binding technique, adapted for transmission electron microscopy, for semiquantitative evaluation of the negative charge density at the surface of HeLa cells in monolayer culture. The surface area increases when HeLa cells spread on the substrate. This increase brings about a decreas... | 332,673 | [
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0.05451025,
0.3039379,
0.2332849,
-0.0018... |
Detection of bacteriuria by automated electrical impedance monitoring in a clinical microbiology laboratory. | An apparatus capable of rapidly detecting changes in electrical impedance was utilized for the continuous monitoring of bacterial growth in routine urine specimens in a clinical laboratory. In a trial study, 200 clinical specimens analyzed by the electrical impedance method resulted in an average detection time of 2.5 ... | 332,712 | [
0.08419855,
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Rapid deoxyribonuclease test with methyl green. | A 4-h deoxyribonuclease test using methyl green to differentiate Serratia from other Enterobacteriaceae was developed. The tests agreed 100% with an overnight plate test for 100 Serratia, 83 Enterobacter, and 6 Klebsiella species. | 332,714 | [
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Rapid screening method for enterotoxigenic Escherichia coli. | A rapid screening method for detection of Escherichia coli producing heat-labile enterotoxin is described. Single colonies are transferred directly from primary culture plates into 96-well microculture plates containing 0.3 ml of brain heart infusion broth in each well. After 24 h at 37 degrees C, each brain heart infu... | 332,715 | [
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0.1421987,
0.04993996,
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The mouse circus: a simple apparatus for thoracic duct cannulation and continuous intravenous infusion. | A simple apparatus is described for maintaining mice during thoracic duct cannulation and/or continuous intravenous infusion, which involves much less restraint than current methods. An Appendix describes the techniques of intravenous cannulation which have been used for prolonged infusion or cardiac catheterisation. | 333,029 | [
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The differential leukocyte count in the assessment and outcome of early-onset neonatal group B streptococcal disease. | The usefulness of the differential white blood cell count in distinguishing early-onset group B streptococcal disease from other causes of neonatal respiratory distress was studied in 45 infants with culture-proved infection. The initial diagnosis was hyaline membrane disease in 19 infants, wet lung syndrome 13, and ot... | 333,072 | [
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0.1359964,
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[The influence of doxepin on the efficiancy of the human heart (author's transl)]. | This work was aimed at clarifying whether the anti-depressant doxepin had a cardiodepressant action, or favoured or initiated arrhythmias and/or ventricular conduction disorders, when administered orally for 14 days at a daily dosage of 75 mg. Under doxepin therapy there was a slight increase in mean heart rate on effo... | 333,252 | [
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0.007568954,
0.04975246,
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Immunestimulation by 4-imino-1,3-diazabicyclo(3.1.0.)-hexan-2-on (BM 06.002). | The new cancerostatic substance 4-imino-1,3-diazabicycle- (3.1.0.)-hexan-2-on was investigated in DBF1 mice in respect to its effects on antibody producing B-lymphocytes and T-lymphocytes. It was shown that BM 06.002 has no definitive influence on immunocompetence when used at a low concentration (1 mg/kg). At higher c... | 333,345 | [
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Prevalence of bovine subclinical mastitis in Malawi. | A survey comprising 934 cows of a total of 1180 from 22 dairy herds and the examination of bulk milk samples from 273 small-holders was carried out. At the time of sampling all known dairy herds and small-holders in Malawi were examined. Since relative few infections other than Staph. aureus and Str. agalactiae were re... | 333,382 | [
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0.352564,
0.129593... |
Hyperpolymer formation during renaturation of DNA from genomes with different sequence organisation. | Hyperpolymer formation during the renaturation of DNAs from wheat, calf and E. coli was studied using hydroxyapatite chromatography, electron microscopy and S1 nuclease. Large hyperpolymers could not be eluted from hydroxyapatite with 0.5 M phosphate buffer at 60 degrees C. Large proportions of wheat and E. coli DNAs w... | 333,391 | [
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Relation between Escherichia coli endonucleases specific for apurinic sites in DNA and exonuclease III. | Contradictory data have recently been published from two different laboratories on the presence vs absence of an intrinsic endonucliolytic activity of E. coli exonuclease III at apurinic sites in double-stranded DNA. It is shown here that an endonuclease activity of this specificity co-chromatographs exactly with exonu... | 333,397 | [
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State of prophage Mu DNA upon induction. | We have compared the process of prophage lambda induction with that of prophage Mu. According to the Campbell model, rescue of lambda DNA from the host DNA involves reversal of lambda integration such that the prophage DNA is excised from the host chromosome. We have monitored this event by locating the prophage DNA wi... | 333,430 | [
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Mechanism of phage phiX174 DNA inactivation by benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide. | A previous report from this laboratory has shown that certain derivatives of polycyclic aromatic hydrocarbons bind to phiX174 DNA and render it noninfectious. The present work describes the relationship between the extent of phiX174 DNA binding by (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and the effect on... | 333,435 | [
-0.2980892,
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... |
Ionic requirements for induction of maturation (meiosis) in full-grown and medium-sized Xenopus laevis oocytes. | There is already good evidence that calcium ions are involved in the induction of maturation in full-grown amphibian oocytes; we show here that other cations (K+, Mg2+) also play a role in this process. Full-grown (1.3 mm in diameter) and medium-sized (0.8-1.0 mm in diameter) oocytes were compared in the present study.... | 333,439 | [
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0.07511853,... |
Large-scale automated isolation of Escherichia coli mutants with thermosensitive DNA replication. | We have screened about 1.4 million colonies of Escherichia coli K-12 for their ability to grow on nutrient agar at 30 degrees and 41 degrees. Among the 2266 temperature-sensitive mutants found, 110 were defective in DNA synthesis but not in protein synthesis at 41 degrees. Three of these dna mutations mapped at two pre... | 333,440 | [
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Interaction of coagulation factor Xa with human platelets. | When human 125I-labeled Factor Xa is incubated with washed platelets, prothrombin, and Ca2+, a small amount of thrombin is formed which causes the platelet release reaction after a period of time that decreases as the Xa concentration is increased from 0.9 to 19 ng/ml. After a further lag period, the Xa binds reversibl... | 333,455 | [
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... |
Neurotensin: immunohistochemical localization in rat central nervous system. | Neurotensin immunofluorescence was examined in the rat central nervous system using a well-characterized antiserum directed against this tridecapeptide. Morphological characteristics of the fluorescence indicate its association with neuronal cell bodies and processes in the brain and with cells of the anterior pituitar... | 333,458 | [
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0.03628102,... |
Method to produce better areolae and nipples on reconstructed breasts. | A method to reconstruct the breast, nipple, and areola after mastectomy is described. The importance of symmetry is emphasized. A split-skin graft is used to reconstruct both (not one) areolae; this provides almost complete symmetry in terms of size, texture, and color. Ultraviolet light is used postoperatively to hype... | 333,483 | [
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0.2234773,
-0.05511991... |
The influence of propranolol on the exposure in vivo of agoraphobics. | This study examines the influence of 40 mg of propranolol on agoraphobics throughout 5-hour periods of exposure in vivo on 3 alternate days. Twenty-three patients were studied using a double-blind parallel design and 19 followed up for 3 months. The propranolol group spent significantly less time than the placebo group... | 333,492 | [
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0.1386196,
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0.2912162,
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0.0752... |
Escherichia coli endotoxin as a stressor in the domestic fowl. | During 24 h after the injection of fowls (aged eight to 11 weeks) with Escherichia coli endotoxin (1 to 3 mg/kg) isolated from a pathogenic strain (O78) there were changes in the ascorbate content of the adrenal gland and increases in the plasma free fatty acid levels, indicating that the toxin behaves as a mild stress... | 333,526 | [
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0.01362486,
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... |
The effect of Freund's complete adjuvant on the cellular immune response in mice to a porcine strain of Escherichia coli lipopolysaccharide. | The effect of Freund's complete adjuvant (FCA), known to enhance and prolong both cellular and humoral responses to thymus dependent (TD) antigens, was studied with regard to the cellular response in BALB/c mice to the thymus independent lipopoly-saccharide antigen of Escherichia coli O138, a porcine pathogen. Techniqu... | 333,529 | [
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-0.1322273,
-0... |
A follow-up study of cleft children treated with vomer flap as part of a three-stage soft tissue surgical procedure. Facial morphology and dental occlusion. | The development of the face and jaws in cleft patients, treated with a three-stage surgical procedure including a single layer vomer flap, was studied by analysing cephalometric radiographs and dental casts. The material consisted of 13 patients with complete bilateral cleft lip and palate and 50 cases with complete un... | 333,561 | [
-0.01872194,
0.2836165,
0.04087739,
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... |
[Mistakes in planning and construction in crown-bridge-prostheses]. | In the planning for crown and bridge prosthetics the harmonizing of function in the remaining dentition seems to be paramount. Occlusal interferences and their neuromuscular consequences may be eliminated by proper occlusal adjustments. Posterior retruded prematurities may function as traumatizing areas and may loosen ... | 333,574 | [
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0.4345981,
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0.09737461,
-0.3260616,
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0.2690993,
0.09934234,
0.1642955... |
Role of preventive antibiotics in patients undergoing cesarean section. | Eighty patients in labor and requiring cesarean section were selected randomly for a double-blind study using prophylactic cephalosporin and placebo. There were 26 treated patients who had no morbidity versus 13 in the control group. The reduction in endometritis was significant (P = less than .05). The most prevalent ... | 333,603 | [
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0.1288746,
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0.02040042,
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0.2819549,
0.2005358,
0.03883622... |
Antibiotic and bacteriologic considerations in open fractures. | A prospective study involving 581 open fracture wounds was conducted to evaluate the antibiotic and bacteriologic considerations in the treatment of open fractures. Multiple cultures were taken of each wound, and each wound had formal surgical irrigation and debridement. An organism was present in at least one of the m... | 333,604 | [
-0.1778526,
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0.1300765,
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0.1703164,
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0.0028465... |
Open-heart surgery. | A randomized prospective study of the relative effectiveness of broad-spectrum versus specific antistaphylococcal antibiotic prophylaxis in open-heart surgery was done between May 1972 and June 1973. All patients undergoing open-heart surgery were assigned randomly (by hospital number) to receive either methicillin (M)... | 333,607 | [
0.06106824,
0.0176417,
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0.01548761,
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0.08084939,
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0.1986758,
0.3205812,
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... |
The use of microvascular free groin flaps for the closure of difficult lower extremity wounds. | Proficiency with techniques of microvascular anastamoses allows the successful transfer of free composite grafts from distant sources. We have used the free groin flap in the reconstruction of defects of the lower extremity not amenable to standard methods of closure. A series of representative cases has been presented... | 333,639 | [
-0.3766857,
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-0.3612418,
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0.1564318,
0.01336691,
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0.1033452,
0.00445305,
0.2802346,
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-0.1966165,
-0.1150254,
0.02921452,
0.2639104,
-0.1919571,
0.16454... |
The effect of length of preservation on renal transplant survival. | Pulsatile preservation of cadaver kidneys for periods of 36 to 67 hours does not adversely affect the success rate following transplantation. Immediate urine output correlated well with an increased chance for short and long term transplant kidney function. No kidneys should be discarded because of perfusion periods as... | 333,642 | [
-0.03402742,
0.04183894,
-0.5333455,
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0.3214265,
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0.192751,
0.1513049,
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0.1583524,
0.1141288,
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0.09493487,
0.1339269,
0.2645079,
-0.1206721,
... |
Ophthalmology in the United States at the time of the revolution. | At the time of the American Revolution, understanding of diseases of the eye was rudimentary, treatment of ocular problems was largely ineffective, and American physicians were highly dependent on their European colleagues for training and development. Knowledge of optics, light and color was somewhat more advanced. Th... | 333,650 | [
-0.1329552,
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0.1656316,
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0.3639247,
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-0.0507006,
0.08513025,
-0.115794,
0.03250087,
0.03483732,
0.1327618,
-0.27051... |
A squash technique for studying the cytology of maize endosperm and other tissues. | A new cytological procedure specifically suited to maize endosperms is presented. It uses 8-hydroxyquinoline with sucrose and aeration to pretreat the tissues. Glusulase is used to spread the cells. The procedure makes it possible to squash endosperms into a single cell layer and to photograph as many as 70 chromosomes... | 333,656 | [
0.14267,
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0.1504878,
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0.01856886,
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0.02441651,
0.3938363,
0.3830766,
0.03895034,... |
A specific enzymeimmunoassay for progesterone in human plasma. | An enzymeimmunoassay for plasma progesterone was established using progesterone covalently linked to the enzyme, horseradish peroxidase, as the 'label'. Separation of free and bound steroid was effected by Sepharose-coupled antiprogesterone-11alpha-hemisuccinyl bovine serum albumin antiserum (Sepharose-antisera). The e... | 333,666 | [
0.1625308,
0.0374517,
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0.08507319,
0.006421273,
0.2206768,
0.4680265,
0.01530194,
-0.1913265,
... |
The laboratory diagnosis of Nairobi sheep disease. | The laboratory methods available for the isolation and identification of Nairobi sheep disease virus have been compared. The results show that inoculation of tissue culture (BHK 21 C 13) with suspensions of infected organs or plasma followed by fluorescent antibody tests on coverslip preparations gave the quickest mean... | 333,678 | [
-0.1707453,
0.0004598699,
0.1276392,
0.1143058,
0.306033,
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0.2129438,
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0.5981238,
0.3140441,
0.2612307,
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-0.... |
[Interaction of the Sindbis virus and Rauscher and Friend leukoviruses in primary cultures and subcultures of mouse fibroblasts in the early stages of persistence]. | The interaction between Friend and Raucher leukoviruses and Sindbis togavirus was studied in primary cultures of mouse fibroblasts and subcultures passaged for 77 days. In primary cultures, two types of virus interactions were observed: neutralism and interference. In interference, the release of the infectious Sindbis... | 333,760 | [
-0.2563705,
0.05563394,
-0.01982056,
0.02811378,
0.4047856,
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-0.085825,
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-0.3436444,
-0.2929586,
0.08394406,
0.3807853,
0.02772922,
0.00323765,
-0.124659... |
[Effect of methylcellulose on protein hydrolysis by pepsin in butter cream]. | The digestiveability of proteins with pepsin in butter creames, where the source of nutrients formed condensed milk, was studied. It was made certain that in specimens containing a greater proportion of butter the proteins were less susceptible to be assailed. When some of the butter is replaced with methylcellulose fo... | 333,755 | [
-0.01912004,
-0.172867,
0.2241179,
0.1733208,
0.05103556,
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0.1698783,
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0.0365404,
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0.06597929,
0.4617881,
-0.2152453,
-0.1065176,
... |
[Results of studying a live mumps vaccine from strain L-3 manufactured by the Moscow Research Institute of Viral Preparations. The reactogenic and antigenic properties of the vaccine]. | The reactogenic and antigenic properties of live mumps vaccine from the L-3 strain were studied in 1507 children of 1 to 12 years of age. A single injection was given, one immunizing dose containing 10(4)HAdU50 of mumps virus. The live mumps vaccine from the L-3 strain irrespective of the lot of preparation, kind (live... | 333,761 | [
0.01238797,
0.0878032,
-0.2945418,
0.1269403,
0.08610312,
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0.4208703,
0.08085598,
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0.279545,
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0.1330989,
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0.15195,
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0.3337476,
0.6434295,
-0.0462851,
-0.1694447,
0.145... |
[Gastric secretory function in peptic ulcer in youth and the effect on it of diet therapy]. | In 110 patients with peptic ulcer aged from 16 to 25 years and in 15 healthy youths the secretary function of the stomach was studied by using fractional tubage with 300 ml of a 7% dry cabbage water as a stimulator. The secretory function was assessed according to the titrated acidity, pepsin and gastricsin data. Inves... | 333,756 | [
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-0.1995852,
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0.4658784,
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0.1673521,
0.3240934,
0.1499943,
-0.1833082,
0.098... |
[New viewpoints on the therapy and prevention of renal osteopathy]. | Dihydrotachysterol which was developed already 50 years ago is above all used in the substitution therapy of hypoparathyroidism. Its parathyreomimetic effectivity has led to an enlargement of the spectrum of indication during the last years; it allows the prophylactic use of dihydrotachysterol in chronic nephropathy in... | 333,796 | [
-0.259353,
0.06739242,
0.05711818,
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0.1580164,
0.2652188,
0.2535868,
-0.1589279,
0.232... |
Gel diffusion--a simple and sensitive technique for the assay of proteinase inhibitors and its use for the determination of the ratio of proteinases in mixtures. | In casein-containing agarose gels, pepsin and chymosin form radial diffusion zones; the diameters of these zones show rectilinear correlations with the logarithm of the enzyme concentration at constant time. The sensitivity for both enzymes is below 1 microgram. Addition of the inhibitor pepstatin A to these enzymes ca... | 333,809 | [
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0.004142689,
0.1014463,
0.05154705,
0.3572678,
-0.05885939,
-0.05536194,
... |
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