title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Kinetics of phagocytosis of Staphylococcus aureus and Escherichia coli by human granulocytes. | Although phagocytosis of micro-organisms by granulocytes is one of the most important defence mechanisms against infection, little is known about the kinetics of this process. The present study showed that the rate of ingestion of Staphylococcus aureus and Escherichia coli depends on the concentrations of the granulocy... | 381,182 | [
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Immunotherapy of guinea pig line 10 hepatoma with nonliving BCG cells in aqueous medium. | Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose displayed a stronger tumor regressive activity and the process of healing was accelerated when endotoxin from a rough (Re)... | 381,203 | [
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Gamma camera scintigraphy in the diagnosis of lymphocele following renal transplantation. | The symptoms and diagnosis of perirenal lymphocele following kidney transplantation are discussed. A case demonstrated by means of i.v. urography and gamma camera scintigraphy is reported. The value of the last mentioned method is stressed. | 381,236 | [
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Evaluation of the mutagenicity of aminoglycoside antibiotics in Salmonella typhimurium and Saccharomyces cerevisiae. | The mutagenicity of aminoglycoside antibiotics (KM, AKM, DKB, RSM, AMK, GM, TOB) has been studied in cells of the bacteria Salmonella typhimurium and in the yeast Saccharomyces cerevisiae. The bacterial strains (Ames') monitor reverse mutation (point mutation) and the yeast strain D5 monitors mitotic crossing-over, mit... | 381,273 | [
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Evidence for mitochondrial localization of the hormone-responsive pool of Ca2+ in isolated hepatocytes. | Conditions are described that allow chlortetracycline, a fluorescent probe of membrane-associated Ca2+, to monitor the content of the major exchangeable pool of intracellular Ca2+ present in the isolated rat hepatocyte. Chlortetracycline fluorescence is decreased in cells whose Ca2+ content is diminished by treatment e... | 381,300 | [
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Potentiation of the chemotherapeutic action of 5-fluorouracil by combination with cytidine or guanosine on HRS-sarcoma. | The chemotherapeutic action of 5-fluorouracil monotherapy on HRS-Sarcoma in mice was compared with those of 5-fluorouracil nucleoside combinations (thymidine, cytidine or guanosine). The curative action of 5-fluorouracil was potentiated without increasing its toxicity, when cytidine or guanosine were applied at definit... | 381,315 | [
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Review of pharmacologic and toxicologic effects of alcohol. | Oral neglect and dental diseases are common; consumption of alcohol is common. To appreciate the frequency of alcoholism, the dental specialist must recognize that no persons will seek attention for alcoholism. Suspicion of alcohol related dental disease is the key. Heavy smoking, malnutrition, bleeding gingiva, cancer... | 381,356 | [
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Rapid diagnosis of tick - borne encephalitis by immunofluorescence assay of specific serum IgM antibodies. | The indirect IF technique, using suspensions of TBE virus infected and uninfected PS cells as antigen-containing substrate, furnishes a rapid and practical test making possible the detection of specific IgM class serum antibodies in the initial stage of clinically manifest TBE. It enables early confirmation of diagnosi... | 381,512 | [
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Characterization of a spontaneous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS. | A spontaneous BALB/c B lymphocyte leukemia could be stimulated in vitro by the polyclonal B cell activator lipopolysaccharide (LPS) and the conditions for activation were studied. Spleen cells or peripheral blood lymphocytes from tumor-bearing animals responded by increased DNA synthesis and the peak of activation occu... | 381,513 | [
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Macromolecular insoluble cold globulin (MICG): a novel protein from mouse lymphocytes. IV. Evidence for the plasma membrane distribution of MICG. | Macromolecular insoluble cold globulin is a glycoprotein synthesized predominantly by T lymphocytes in the mouse. The present report details experiments demonstrating the plasma membrane distribution of MICG on T lymphocytes. By utilizing immunofluorescent techniques it was shown that MICG was located in the external c... | 381,514 | [
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Aerobic and anaerobic metabolism during activity in small rodents. | Analysis of oxygen consumption and lactic acid formation during five minutes of maximal activity by the rodents Microtus montanus (Cricetidae) and Dipodomys merriami (Hetermyidae) indicates that: (1) anaerobiosis provides approximately 10% of total energy utilized during the 5-minute activity period; (2) anaerobiosis m... | 381,568 | [
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Delayed hypersensitivity reactions in guinea-pigs using cotton pellets; demonstration of macrophage migration inhibition activity in the cell free exudate. | Subcutaneous implantation of cotton pellets containing PPD into CFA sensitised guinea-pigs produced a reaction of having many characteristics of the delayed hypersensitivity (DH) reaction, together with less conspicuous features of a non-immunological response. The time course of the cellular response in the reaction s... | 381,610 | [
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Disturbed fat absorption following infectious gastroenteritis in children. | Fat absorption was studied in 10 patients recovering from an episode of acute infectious gastroenteritis who failed to gain weight despite adequate caloric intake. Three patients restudied after clinical improvement and three other infants with failure to thrive, unrelated to gastrointestinal problems, served as contro... | 381,617 | [
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The effect of an alexidine mouthwash on plaque and gingivitis. | A clinical study was conducted on the effects of an alexidine or placebo oral rinse on plaque and gingivitis. Forty-two male subjects rinsed for 54 days while continuing toothbrushing. This was followed by 4 days of mouthrinsing only. The alexidine mouthrinse significantly reduced the plaque index when used in conjunct... | 381,628 | [
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Neural tube malformations: complex segregation analysis and calculation of recurrence risks. | Familial data on neural tube malformations in Great Britain were submitted to segregation analysis under the mixed model. Maternal and fetal factors cannot be discriminated in the absence of substantial bodies of data on spina bifida survivors who reproduce or on half-sibs. Early abortion studies would allow differenti... | 381,662 | [
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Assay of the heat-labile enterotoxin of Escherichia coli in infant rabbits. | Infant rabbits were shown to respond to Escherichia coli heat-labile enterotoxin by a consistent increase in intestinal fluid content, which was maximal 5 h after oral dosing. Infant rabbits could be used in a simple quantitative assay for heat-labile E. coli enterotoxin based on the ratios of gut weight to remaining b... | 381,666 | [
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Impaired renal allograft function: a comparative study with angiography and histopathology. | We reviewed 47 renal transplant recipients who had undergone angiography and transplant biopsy to evaluate impaired allograft function. Angiographic criteria for rejection were seen in all allografts with hyperacute rejection, accelerated rejection and chronic rejection, and in 13 of 17 allografts with acute cellular r... | 381,688 | [
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A direct hepatotoxic effect of valproic acid. | Nine patients treated with valproic acid had low plasma fibrinogen concentration and other liver function abnormalities. Several patients also had a low platelet count and prolonged bleeding time. The abnormal values returned promptly to normal when the drug therapy was discontinued or the dosage reduced. The liver fun... | 381,698 | [
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Free hypothenar full-thickness grafts for distal digital defects. | The application of free full-thickness grafts of palmar skin from the hypothenar area is advocated for full thickness digital tip defects too large for open treatment. The traditional objection to this site as a donor for full-thickness skin on the basis of sensitivity and pain has not been confirmed. Strict, meticulou... | 381,756 | [
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[Soluble mediators as a means of communication between lymphozytes in immune reactions (author's transl)]. | Soluble mediators play an important role in the positive and negative regulation of immune reactions. This has been particularly well documented for T-B-cooperation in the humoral immune response to T-dependent antigens. T-helper cells produce a T-cell replacing Factor (TRF) upon mitogenic or antigenic stimulation. It ... | 381,769 | [
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Characterization of human pepsin I obtained from purified gastric pepsinogen I. | Immunochemical homogeneous human pepsinogen I-group (PgI) was purified by solid immunoadsorbent and by DEAE-chromatography from gastric mucosa. PgI contained five electrophoretic distinct bands at pH 8.2 but only four bands at pH 5.6. After acid activation human pepsin (PI) was separated from the inhibitory peptide by ... | 381,770 | [
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A comparative trial of daunorubicin, cytosine arabinoside, and thioguanine, and a combination of the three agents for the treatment of acute myelocytic leukemia. | In this study 523 previously untreated patients with acute myelocytic leukemia were randomly allocated to induction therapy with daunorubicin 60 mg/M2 daily X 3, cytosine arabinoside and thioguanine 100 mg/M2 each every 12 hours until marrow hypoplasia was achieved, or a 5-day course of the three drugs with daunorubici... | 381,887 | [
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The induction of sex-chromosomal nondisjunction and diploid spermatids following x-irradiation of pre-spermatid stages in the northern vole Microtus oeconomus. | Chromosome nondisjunction seems to be one of the most important mutagenic effects occurring in man and makes an enormous contribution to human foetal wastage. As yet, little or no information is available on which environmental factors are important in inducing nondisjunction and accordingly we have investigated the ef... | 381,906 | [
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The action of pepsin on the reserve proteins of some leguminous seeds. | The action of pepsin on the 11-S and 7-S proteins of vetch, 11-S protein of soybean and 7-S protein of Phaseolus vulgaris was investigated. The first three proteins are hydrolyzed almost completely, the rate of hydrolysis being close to that of hemoglobin, while the hydrolysis of Ph. vulgaris 7-S protein stops after th... | 381,930 | [
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[Quantitative determination of cells in sterile skin exudate in acute cerebrovascular diseases]. | Rebuck's test was done in 126 subjects (40 healthy controls and 86 patients with acute cerebrovascular disease) on both upper extremities. In the control group no statistically significant quantitative difference was found in the number of cells in the exudate on both sides. In the patients, however, the number of cell... | 381,958 | [
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Rat gonadotropin release stimulated in vitro by GnRH-depleted rat brain extracts. | A study was made to compare the LH and FSH release patterns from isolated adult rat pituitaries in response to exposure to acidic extracts of rat hypothalamus or brain or to acidic extracts of GnRH-depleted hypothalamus, cerebral cortex, or cerebellum of adult (90-100 days old) or young (14 days old) rats of both sexes... | 381,967 | [
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Common aspects of immunologic tolerance in pregnancy and malignancy. | The fetoplacental allograft and the malignant neoplasm represent the only 2 biologic conditions in which antigenic tissue is tolerated by a seemingly intact immune system. Recent investigations in the fields of tumor and pregnancy immunology have resulted in the recognition of a variety of immunologic mechanisms which ... | 382,002 | [
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[About the different steps leading to the quality of medical informations (importance of medical computing (author's transl)]. | To draw the best conclusions from a set of medical data, one must first choose correct, valid, representative and well-expressed information. So it's not sufficient to collect data, but we have to valid them before including them in the records. After having put out the general characteristics of any validation and def... | 382,056 | [
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Domperidone for the symptomatic treatment of chronic post-prandial nausea and vomiting. | Forty patients with postprandial nausea and vomiting from a variety of underlying causes, were given either domperidone 20 mg t.d.s. or placebo in a double-blind study lasting two weeks. The tablets were taken before meals and no other anti-emetics were used. Nausea and vomiting were reduced in those patients given the... | 382,152 | [
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The respiratory response to pregnancy. | The respiratory response to pregnancy appears to be largely mediated by the action of progesterone and, perhaps to a lesser extent, oestrogens, at least in the first and second trimesters. The mechanical effects of the gravid uterus cause relatively little change in pulmonary mechanics, although finer changes in airway... | 382,162 | [
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Respiratory disease in pregnancy. | Respiratory disorders seem to be better tolerated during pregnancy than disorders of the cardiovascular system. Pregnancy seems to have a variable effect on bronchial asthma although respiratory function in general shows little change. Similarly patients with bronchiectasis do not tend to show functional deterioration.... | 382,163 | [
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Comparative susceptibility and effect of mild Aspergillus fumigatus infection on three strains of chickens. | A single Comb White Leghorn strain (Dryden X Auburn = DAX) was more susceptible to Aspergillus fumigatus infection and suffered significantly greater mortality than the Athens-Canadian or a Vantress X Arbor-Acres cross exposed soon after hatching. The unexposed controls of the three types weighed significantly more tha... | 382,171 | [
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Interaction of radiofrequency and microwave radiation with living systems. A review of mechanisms. | Human health aspects and biological effects of radio frequency (RF) and microwave radiation have been in the focus of research efforts in the last decade. An understanding of the interaction mechanisms between such radiation and living systems is essential in interpreting experimental results and assessing potential he... | 382,232 | [
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Gray scale ultrasound and the genitourinary tract. A review of clinical applications. | Diagnostic ultrasound has many well established indications in the evaluation of genitourinary tract disease. Musch of this information complements or corroborates findings derived from other investigations. The role of ultrasound as a primary diagnostic modality is still evolving, but it appears to be useful in a vari... | 382,237 | [
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Did Röntgen discover the X ray by himself? | The historical background of the discovery of the x ray and some of Lenard's claims to priority are discussed. There is no doubt that the x ray is the sole discovery of Wilhelm Conrad Röntgen. | 382,244 | [
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Continuing education: evolution or revolution: II. What about the future? | Having previously written something about the 'roots' of the radiologic technology profession, the author now concentrates on where it goes from here. What are the implications of the demand for accountability on the educational process? How does it adjust to changing technology? What are the future career prospects? H... | 382,238 | [
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Oral hypoglycemic drugs and cardiovascular pathology. | The classification, the mechanisms of action and the main side effects of sulfonylureic derivatives and biguanides are discussed. Emphasis is laid on the present controversy concerning the assumed adverse effect of these drugs on the cardiovascular system. The authors' opinion in this problem and their practical conclu... | 382,336 | [
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Ureteral obstruction by aorto-iliac aneurysms--a common complication? | During a 4-year-period, 5 cases of ureteral obstruction by aorto-iliac aneurysm were detected. Over the same period 50 aorto-iliac aneurysms were resected. One of the 5 patients was not operated on. In the remaining 4, the aneurysm was resected and replaced by a Dacron bifurcation graft. Nephrectomy was performed in th... | 382,345 | [
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[Correlations between the secular trend in sugar consumption in England and the secular increase of brain weight in adults in London between 1860 and 1940]. | Significant positive correlations exist between the secular increase in brain weight of adults in London born between 1860 and 1940, and the secular trend in sugar consumption in the United Kingdom. These results of statistical analysis confirm once again the important bearing of excessive sugar consumption on the deve... | 382,347 | [
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[Benign symmetric lipomatosis: a symptom of alcoholic liver disease?]. | Benign symmetric lipomatosis (BSL) leads to characteristic multiple lipomas of the neck and submandibular region. BSL is easily diagnosed by its typical feature, "Madelung's neck". However, the early stages are often missed or lead to futile diagnostic endeavours. A report is presented on 7 men with BSL aged 36--65 yea... | 382,349 | [
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Conflict in teamwork: understanding roles and relationships. | Out of the recognition that chronic renal failure has psychological and social as well as medical ramifications, the renal treatment team is composed of different professionals. As these disciplines respond to the psychosocial and medical dimensions, potential for role conflict arises. The paper focuses on this problem... | 382,405 | [
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Current status of surgery of the omentum. | The greater omentum is a unique organ with multipotential properties. A simple procedure converts it into a vascularized pedicle that may be utilized throughout the body. Knowledge of the possible applications of free or pedicled omental grafts will significantly add to the armamentarium of a clinical and experimental ... | 382,412 | [
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Frequency of blood group antigens in Nigerian children with falciparum malaria. | The frequencies of the following blood group antigens: A, B, O, M, N, S, s, U, Fya, FyB, Lea, Jsa and K have been determined in Nigerian children with severe falciparum malaria. The frequency distribution of M, N, S, s, U, Fya and Fyb were not significantly different in children with life-threatening falciparum malaria... | 382,466 | [
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Isolation and identification of mycobacteria from cattle slaughtered in Pakistan. | Specimens of lung, liver and mesenteric lymph node from cows and buffaloes slaughtered in the Lahore area were cultured to investigate the type of mycobacteria involved in bovine tuberculosis. Employing the concentration method, 56 out of 530 cattle were found to be culture positive for acid-fast bacteria, 48 being Myc... | 382,608 | [
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[Double flap method in the frontal and temporal area to cover larger defects left by surgery]. | Regional flaps are often necessary to cover defects left after operations in the forehead and temple area, since the skin of the scalp does not stretch well and because of the likelihood of dislocation of the eyebrow. We find the double advancement-flap technique using curving incisions of great use in this area. These... | 382,662 | [
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A simple method for the separation of tissue-cultured plant cells from unbound bacteria: a demonstration of acquired affinity for bacteria by cells of soy bean. | Tissue-cultured cells of soy bean, grown in liquid medium and then transferred to an agar substratum in so-called tissue chambers, showed an affinity for the binding of applied bacteria (Klebsiella pneumoniae). This binding, which became greater as the plant cells remained on the agar for up to 10 days, was manifested ... | 382,698 | [
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Diagnosis of postnatal rubella by the enzyme-linked immunosorbent assay for rubella IgM and IgG antibodies. | A semi-automated enzyme-linked immunosorbent assay (ELISA) was established for the detection of rubella IgM antibodies in non-fractionated sera. A cut-off level between rubella IgM positive and negative sera was determined by a study of sera without rheumatoid factor from 200 blood donors. Testing of 12 donor sera cont... | 382,737 | [
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Mouse lung oedema caused by a toxic substance of Escherichia coli strains. | Some Escherichia coli strains isolated from patients and instilled into the nostrils of mice cause a rapidly developing fatal, haemorrhagic lung oedema. Lung toxic strains were found in different serogroups, with the predominance of 04, 06, and 018. The toxic material seems to be bound to the cells; the toxin yield is ... | 382,757 | [
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The pharmacological consequences of the binding of anti-rheumatic drugs to plasma proteins in the treatment of rheumatoid arthritis. | Evidence is presented that rheumatoid arthritis is a disease resulting from abnormal protein binding and that anti-rheumatic drugs act by correcting the abnormal binding. | 382,804 | [
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Lupus nephritis. Electron-dense and immunofluorescent deposits and their correlation with proteinuria and renal function. | Thirteen patients who had systemic lupus erythematosus were studied for the purpose of correlating the findings of light and electron microscopy and immunofluorescent studies with renal function and the presence of proteinuria. Subendothelial deposits of electron-dense material were found in all biopsy specimens, where... | 382,826 | [
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Rapid in vitro capsule production by cryptococci. | Four agar media (blood, corn meal, chocolate, and Sabouraud's) and four liquid media (brain-heart infusion broth, one percent peptone broth, pooled human serum, and lyophilized rabbit coagulase plasma) were evaluated for their ability to enhance the production of capsules from four strains of Cryptococcus yeast within ... | 382,848 | [
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Bacterial growth inhibition by amniotic fluid. VIII. Evaluation of a radiometric bioassay for rapid, in vitro demonstration of phosphate-sensitive bacterial growth inhibitor in amniotic fluid. | A radiometric bioassay based on the continuous monitoring of 14CO2 released from labeled glucose in the presence of amniotic fluid or amniotic fluid with added phosphate has been employed to detect the presence of a phosphate-sensitive bacterial inhibitor in amniotic fluid near term. The time required for detection of ... | 382,854 | [
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0.0342... |
The tumoricidal properties of inflammatory tissue macrophages and multinucleate giant cells. | Peritoneal exudate cells from C3H/HeN mice infected with bacille Calmette Guérin (BCG) and subcutaneous inflammatory macrophages from uninfected mice exhibit spontaneous cytotoxicity for tumor cells in vitro, but their tumoricidal activity can be increased by incubation in vitro with lymphokines released by mitogen- or... | 382,866 | [
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A method of intrarenal blood flow measurement using xenon-133 in the intact rat. | A method is described for measuring distribution of intrarenal blood flow in anesthetized rats by a xenon-133 washout technique that avoids the trauma of opening the abdominal cavity and manipulating the kidney. Precise delivery of the tracer to the kidney and fine collimation of the radiation reduces the amount of tra... | 382,873 | [
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Endotoxin absorption in hay-fed and lactic acidotic sheep. | Absorption of endotoxin from the gastrointestinal tract was evaluated in hay-fed and lactic acidotic sheep duodenally infused with 10 mg of Escherichia coli endotoxin, and in lactic acidotic sheep not infused. The effect of abomasal fluid on biological activity of endotoxin was also evaluated. Leukopenia was the criter... | 382,927 | [
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... |
Immunogenic complexes obtained from Salmonella typhi-murium and Salmonella typhi Ty2 by the bacterial acetone powder method. | An immunogenic complex was isolated from Salmonella typhi-murium and another one from Salmonella typhi Ty2. Both were prepared by the bacterial acetone powder method which eliminated the cell wall, the DNA almost completely and the membrane phospholipids. The complexes were denominated "New Vaccines". The S. typhi-muri... | 382,951 | [
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Fifth Daniel C. Baker Jr. Memorial Lecture. Resident education: past, present and to where. | The specialties in medicine and surgery developed slowly during the later 19th century and the early decades of this century. The American boards were the focal points for sponsoring specialty societies through which these developments occurred. The resident review committees have also played an important role. Otolary... | 382,959 | [
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Viroimmunoenzymoassay for detection of anti-penicilloyl antibodies and penicilloyl residues: comparison of results obtained by radio-, viro- and enzymoimmunoassay. | A new technic named viroimmunoenzymoassay is described. The principle is the same as the classical viroimmunoassay which uses as tracer a bacteriophage bound covalently to an hapten. Immuno-specific neutralization of these modified bacteriophages by an hapten antiserum allows to detect and to test hapten antibodies or ... | 382,975 | [
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Effects of pethidine and its antagonists on the newborn. | Nalorphine and naloxone were compared as to their effectiveness as pethidine antagonists. 85 infants were divided into a control group containing 19 newborn babies whose mothers did not receive pethidine and the babies received no antagonist, and three groups in which the mothers all received pethidine and the babies h... | 383,023 | [
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Practical aspects of selection of streptomyces mutants. | The methods of industrial strains selection on the basis of some regulatory mechanisms are presented. The selection of the producing S. erythreus mutants exhibiting higher activity for transformation of erythromycin C to erythromycin A is one of the examples for the practical use of the presented method. Some new techn... | 383,039 | [
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[Anti-toxoplasma antibodies in bovine serums in Jaboticabal County; São Paulo, Brazil]. | Sera of 204 cows in Jaboticabal, S.P., Brazil were examined by indirect immunofluorescent test for detecting anti-Toxoplasma antibody. Assuming titers from 1:64 as indicative of toxoplasmic infection it was observed 32.3% of positive reactions. The antibody titers even to 1:256 represented 7.8% of the reacting animals.... | 383,047 | [
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[Physiological basis for a cochlear prosthesis (author's transl)]. | For the attempt to develop a cochlear prosthesis, which allows some understanding of speech, it seems--at least for the first attempts--to be appropriate to mimic natural conditions as far as possible. The auditory nerve contains about 30,000 afferent fibres. Qualitatively, their behavior is similar but quantitative me... | 383,060 | [
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The treatment of breast cancer in a French anticancer centre. | The complete protocol for the treatment of breast cancer at the Institute Gustave Roussy, Villejuif, France, is presented. Treatment is carried out by a multidisciplinary committee dealing with nearly one thousand new breast cancers annually. The protocol is based on initial classification by the T.N.M. system and by c... | 383,065 | [
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[The incidence of abnormal EEG patterns with clozapine therapy (author's transl)]. | During treatment with clozapine 59% of 127 patients showed abnormal EEGs. Remarkable are paroxysmal disturbances with sharp waves and/or SW-pattern in ca. 13%. Generalized tonic-clonic convulsive cereberal seizures were observed only twice. | 383,098 | [
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[Additional treatment to lithium prophylaxis of affective psychoses (author's transl)]. | Ten endogenous-depressive patients under lithium maintenance therapy participated in a group behaviour therapy program for the modification of behavioural problems that are typical for this group of patients. The problem intensity as measured individually through a "problem barometer" as well as the score on the Pt-sca... | 383,101 | [
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[Routine EEG examinations accompanying lithium therapy over two years (author's transl)]. | In 15 lithium-treated psychotic patients, the following variables were examined over two years at 6-monthly intervals; seru lithium levels, serum electrolytes, thyroid function, urinary creatinine and urea, and clinical EEG. The mean serum lithium level was 0.64 mval/l and did not change during the two years. When comp... | 383,102 | [
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Accelerated remission of the alcoholic organic brain syndrome with EMD 21657. Double-blind clinical and psychometric trials. | The efficacy of EMD 21657--a derivative of a pyritinol metabolite--on the alcoholic orangic brain syndrome (OBS)) was investigated in a double-blind placebo-controlled study. 19 patients received 3X300 mg EMD, 21 patients 3X1 dragée placebo throughout 6 weeks. The two groups did not differ as to age, sex, weight, heigh... | 383,103 | [
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[Dedo and Fishman technique for laryngeal release in cervical tracheal reconstruction (author's transl)]. | The Authors report two cases of tracheal tumor operated with laryngeal release and tracheal mobilization following Dedo and Fishman. They discuss the indications and describe this technical procedure which has proved successful in obtaining a suture without traction also for 4 cm sleeve resection of trachea. | 383,110 | [
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Aortic valve replacement in a case of Ehlers Danlos syndrome. | A case of Ehlers Danlos syndrome is described in a 54-year-old Caucasian male. He had calcific aortic valve disease and dilatation of the ascending aorta. An aortic valve replacement was performed using a Starr prosthesis. | 383,121 | [
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Lactoperoxidase activity in guinea-pig milk and saliva: correlation in milk of lactoperoxidase with bactericidal activity against Escherichia coli. | The lactoperoxidase (LPO) activity in guinea-pig milk and saliva has been investigated in sows suckling normal young, and young orally infected with Escherichia coli. There was a 5-fold increase in activity in milk during the 3--4 weeks of lactation; infection of the young did not alter this. There was no comparable in... | 383,128 | [
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Detection and quantification of platelet-bound antibodies with immunoperoxidase. | The use of immunocytochemical techniques enables one to quantify antibodies bound to cell membranes. We have tested the platelets of subjects with immune thrombocytopenic purpura by this method. The washed platelets were incubated in the presence of antiglobulin conjugated with an equimolar amount of peroxidase. The fi... | 383,134 | [
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Isoleucyl transfer ribonucleic acid synthetase. Steady-state kinetic analysis. | A steady-state kinetic analysis was conducted of the overall aminoacylation reaction catalyzed by isoleucyl-tRNA synthetase. The patterns of Lineweaver-Burk plots obtained indicated that tRNA adds to the enzyme only after isoleucyl adenylate formation and pyrophosphate release. These kinetic patterns were consistent wi... | 383,140 | [
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High-resolution phosphorus nuclear magnetic resonance spectra of yeast phenylalanine transfer ribonucleic acid. Melting curves and relaxation effects. | In a continuation of our studies on structural effects on the 31P chemical shifts of nucleic acids, we present 31P NMR spectra of yeast phenylalanine tRNA in the presence and absence of Mg2+. Superconducting field (146 MHz) and 32-MHz 31P NMR spectra reveal approximately 15 nonhelical diester signals spread over approx... | 383,146 | [
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Variant forms of matrix protein in Escherichia coli B/r bearing N plasmids. | Plasmids of the N incompatibility group have been found to decrease or virtually eliminate the synthesis of the 36,500 dalton outer membrane matrix protein of their Escherichia coli B/r hosts (Iyer, R. (1977) Biochim. Biophys. Acta 470, 258--272 and Iyer, R., Darby, V. and Holland, I.B. (1978) FEBS Lett. 85, 127--132) ... | 383,151 | [
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Kinetics of changes in lymphoid organ weight and the cellular composition under leukosis of the latter, inoculated with different amounts of cells. | The authors studied the kinetic pattern of weight change in lymph glands, spleen, thymus, and their cellular composition during the development of mouse reticulosarcomatosis and Shvets' leukosis when the transplant contained different numbers of tumor cells. They found that during the development of reticulosarcomatosi... | 383,161 | [
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The effects of prostaglandins on secretion of glucagon and insulin by the perfused rat pancreas. | The secretion of both glucagon and insulin by the isolated perfused rat pancreas was significantly stimulated by 10(-7) M PGH2. Experiments to show that the stimulated secretion was mediated by conversion of PGH2 to TXA2 or TXB2 revealed no correlation between the amount of secretion and the amount of thromboxane forme... | 383,232 | [
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Purification and Best Department of Medical Research, University of Toronto, Ont., Canada. | Factor EF-P is a nonribosomal (soluble) protein of Escherichia coli that stimulates peptide bond synthesis when certain aminoacyl-tRNA analogues are used. The purification of this protein to apparent homogeneity is described here. EF-P has a molecular weight of about 21 000, a Stokes radius of 27 A (1A = 0.1 nm), and a... | 383,236 | [
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Phase I-II study of ftorafur and methyl-CCNU in advanced colorectal cancer. | The combination of Ftorafur (NSC-148958) and methyl-CCNU (NSC-95441) was evaluated in 36 patients with advanced colorectal cancer. The principle toxicities encountered were myelosuppression, gastrointestinal, and neurological. There were no complete responses and only 5/34 (14.7%) patients achieved a partial response. ... | 383,275 | [
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Production of fibronectin by human epithelial cells in culture. | Human epithelial cell lines derived from both carcinomatous and nomalignant tissues were characterized with respect to the presence and distribution of fibronectin by immunofluorescence microscopy. In cell lines derived from nonmalignant tissues or from primary carcinomas, fibronectin was found predominantly in an extr... | 383,280 | [
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High-dose BCNU therapy with autologous bone marrow infusion: preliminary observations. | Nine patients with solid malignancies and extensive prior treatment received high-dose BCNU therapy (600--750 mg/m2) with autologous bone marrow support; following this treatment hematopoietic recovery was studied. The only significant nonhematopoietic toxicity was a probable case of BCNU-induced pulmonary toxicity in ... | 383,292 | [
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Peptide hormone-like immunoreactivity in the gastrointestinal tract and endocrine pancreas of eleven teleost species. | The distribution of peptide hormone-like immunostaining in the gastrointestinal tract of 11 teleost species was investigated by immunofluorescence. Cells immunoreactive for somatostatin were found in the glandular epithelium of the stomach of four species and in the epithelium of the pyloric appendage of one species. T... | 383,303 | [
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[Changes in fluorescent antibodies in experimental bilharziasis with S. mansoni and S. haematobium in mice. Comparison of the results obtained using homologous and heterologous antigens]. | Fluorescent antischistosomiasis antibodies appear earlier in mice infected by 150/200 cercariae than in those who only received 20. The use of a homologous antigen in mice infected by S. mansoni or S. haematobium allows earlier and more important responses. The infections by S. haematobium seem to determinate in mice a... | 383,309 | [
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... |
Immunological changes observed in indeterminate and lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. | This investigation was carried out to study the possibility of eliciting favourable immunological changes in small groups of Mitsuda-negative patients with indeterminate leprosy, lepromatous patients who were bacteriologically negative after prolonged treatment with sulphones, and in Mitsuda-negative contacts by means ... | 383,331 | [
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0.4300534,
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The bone inductive capacity of various bone transplanting materials used for treatment of experimental bone defects. | The bone defect repairing capacities of autogenous cancellous bone (ACB), decalcified bone (DB), autodigested "low-antigenic" bone matrix (LBM) and preserved bone (PB) were tested in experimental defects in rabbit scapulae. The healing of the defects was most effective with ACB transplants as judged by roentgenologic a... | 383,339 | [
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0.01892446,
0.03828702,
0.1066761,
-0.1468338,
-0.3074611,
-0.3024967,
0.1256901,
0.06779465,
-0.02230837,
0.02416397,
0.01343161,
-0.08339719,
-0.1710167,
-0.4230562,
0.07164469,
-0.1626767,
-0.1273624,
0.0847302,
0.2948322,
0.4515549,
0.3841765,
-0.1486177,
... |
Noninvasive monitoring of intracranial pressure: a new approach for neonatal clinical pharmacology. | Measurements taken with the pressure-activated fiberoptic sensor should provide better insight into the relative usefulness of various agents such as glycerol and corticosteroids in the reduction of intracranial pressure. It is also useful in monitoring pressure changes during asphyxia-hypoxia, convulsions, and anesthe... | 383,359 | [
-0.1627036,
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0.1748588,
-0.05213596,
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0.003339342,
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0.09580044,
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0.2604772,
-0.267843,
0.02135647,
-0.04600816,
-0.1846021,
0.00... |
[Contact eczema caused by 1,4-bis-chloromethylbenzene]. | Approximately 3 days of contact to 1,4-bis-chloromethylbenzene of a 24-year old chemistry student led to a bullous contact eczema within approx. 10 days. Patch tests with the substance proved definitely positive. A weak reaction also occurred with 1,4-bis-mercaptomethylbenzene, for the synthesis of which the chlorometh... | 383,436 | [
-0.08540671,
0.1050819,
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0.120378,
0.2373219,
0.0008264915,
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0.624867,
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0.187716,
0.2198857,
0.3890951,
0.0244648,
... |
Fixation of skin grafts in the horse using stainless steel staples. | Three horses with a chronic wound on the distal part of a leg were treated successfully by grafting. Small split skin grafts were fixed onto pieces of adhesive tape. The tape pieces were spread over and fixed to the granulation surface with stainless steel staples. A tight pressure bandage including strongly compressed... | 383,478 | [
0.09693976,
0.0789243,
0.2801653,
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0.1973259,
0.08178779,
-0.01225706... |
Effect of high-dose prednisone on renal hemodynamics of normal and transplanted dog kidneys. | The effect of prednisone therapy on renal hemodynamics was studied in normal, autotransplanted as well as homotransplanted dog kidneys. After intravenous administration of prednisone (8 and 16 mg/kg/min) the total blood flow decreased and vascular resistance increased significantly. This effect was more pronounced if t... | 383,484 | [
-0.08972455,
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0.016824,
0.1218377,
0.2330398,
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... |
Analysis of inherited epilepsy using single locus mutations in mice. | The neurological expression of mutations at defined gene loci in isogenic mice provides a singular opportunity to investigate the developmental pathophysiology of inherited central nervous system (CNS) diseases. Analysis of the single locus mutants that are currently available shows that CNS diseases that include spont... | 383,515 | [
0.2123861,
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0.1877755,
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0.2879912,
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0.3615561,
-0.08216254,
... |
Effect of norepinephrine on insulin, glucagon, and somatostatin secretion in isolated perifused rat islets. | The rate of insulin, glucagon, and somatostatin secretion was measured from isolated rat islets maintained in a perifusion system. The effect of norepinephrine (NE) was simultaneously determined on the release rate of all three hormones. Norepinephrine was employed at an acute dose of 10 micrometers and in graded doses... | 383,555 | [
-0.1463454,
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0.1122906,
0.2134916,
0.1734956,
0.2739622,
0.1653284,
0.129439,
0.1733851,
0.001... |
Modulation of human gastric mucosal adenylate cyclase activity by prostacyclin. | Prostacyclin, its stable metabolite 6-keto-prostaglandin F1 alpha and prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1 alpha (each 0.28 mM... | 383,560 | [
-0.2356405,
0.02534896,
-0.3753705,
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0.2511524,
0.2469258,
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0.03693979,
0.07902531,
0.4403767,
0.4178863,
0.0743636,
-0.1376752,
... |
Endotoxin toxicity in rats with 6-sulfanilamidoindazole arthritis. | Seven oral administrations of 6-sulfanilamidoindazole (6-SAI) to 10- to 12-month-old rats sensitized the animals to endotoxin, with dosages as small as 2.5 microgram causing death in 80% of animals. Endotoxin in a dosage of 3,000 microgram was not lethal for nonmedicated control animals. 6-SAI-treated 1-month-old rats ... | 383,619 | [
-0.006173985,
0.1414682,
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0.1832075,
0.1806616,
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0.166462,
0.3965428,
0.1620896,
0.3700792,
0.0282941,
-... |
Human trabecular cells. I. Establishment in tissue culture and growth characteristics. | After a careful dissection of trabecular tissue from recent postmortem specimens, human trabecular cells were established in tissue culture with 250 ng/ml fibroblast growth factor (FGF), Dulbecco's modified Eagle's medium (DME), and 10% human serum. These conditions have allowed propagation of human trabecular cells fo... | 383,640 | [
-0.194111,
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0.1511986,
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0.1098886,
0.1402453,
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0.4416319,
0.3468926,
0.2104759,
-0.007270254... |
The present status of imaging of the gallbladder. | Oral cholecystography is still the basic modality for the diagnosis of gallbladder disease. Now, for the first time since the introduction of this procedure in 1924, this status is being challenged by another diagnostic technique, ultrasonography of the gall bladder. Ultrasound studies have major advantages over conven... | 383,643 | [
-0.2219649,
0.04468097,
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0.4194163,
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0.1136749,
0.5439494,
0.03344333,
0.08012549,... |
[Cosmus Conrad Cuno (1652-1745) on a human ectoparasite: the head louse]. | Cosmus Conrad Cuno, a less well known optician and inventor of microscopes from the second half of the 17th century, published in 1734 at Augsburg his Observationes durch dessen verfertigte Microscopia where along with various observations he communicated salient details pertaining to the biology of the head louse. | 383,656 | [
0.07804,
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0.0515055,
0.2474328,
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0.0748248,
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0.3177969,
0.1689837,
0.04832531,
0.1043719,
0.357266,
-0.2240081,
0.23187... |
[Hearing results following tympanoplasty (author's transl)]. | Tympanoplasty can produce a stable hearing improvement in many patients with chronically inflamed ears. In our series of patients, severe damage to the inner ear following surgery occurred in 3% patients and was associated with a hearing loss of greater than 15 dB. Complete hearing loss occurred in 0.2% of the patients... | 383,667 | [
0.01596432,
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0.2358056,
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-0.2976265,
0.1260654,
-0.06720754,
-0.009817731,
0.4375761,
-0.259109,
0.013... |
New tool for studying interactions of components of ribonucleic acid polymerase: rifampin-dependent mutants. | Mutants of Escherichia coli showing a rifampin-dependent phenotype were isolated from cells of strain CP78 mutagenized with ethyl methane sulfonate or nitrosoguanidine when an antibiotic underlay technique was used. The mutants varied greatly in their rifampin requirement. The minimum necessary concentration ranged fro... | 383,684 | [
-0.2499686,
0.06176745,
0.05571904,
0.1093369,
0.02806241,
0.09952549,
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0.1346729,
0.3938763,
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0.01739495,
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0.4799839,
0.2195857,
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0.2141955,
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-0.2220402,
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0.1395176,
0.1890918,
-0.1007101,
0.1548892,
0.0... |
Ribosomal ribonucleic acid isolated from Salmonella typhimurium: absence of the intact 23S species. | Ribonucleic acid (RNA) isolated by four distinct methods and from a variety of Salmonella typhimurium strains lacked intact 23S ribosomal RNA (rRNA). On sucrose gradients which minimize aggregation, the vast majority of S. typhimurium rRNA sedimented as a 16S peak with a 14S shoulder. RNA from this region of the gradie... | 383,696 | [
-0.2969818,
0.4650097,
0.09765335,
-0.3554292,
-0.3240703,
-0.2972939,
-0.4747032,
0.0619473,
0.171823,
0.1790937,
0.2097795,
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-0.04006188,
0.1747016,
0.1951306,
-0.09286957,
-0.1794217,
-0.2499882,
0.3427637,
0.4873666,
-0.0955045,
-0.1382892,
0... |
Cistrons encoding Escherichia coli heat-labile toxin. | The structure and products of the two cistrons encoding the Escherichia coli heat-labile toxin (LT) were studied. The LT deoxyribonucleic acid (DNA) region had been isolated as part of a DNA fragment from the plasmid P307, and this fragment was joined to the cloning vector pBR313. Deletion mutations of various lengths ... | 383,697 | [
0.03379791,
0.1916127,
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0.04946978,
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0.09299234,
0.1348309,
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0.3428606,
-0.03002053,
0.4719057,
0.3092223,
-0.209... |
Trazodone, a new antidepressant: efficacy and safety in endogenous depression. | The effectiveness of trazodone was assessed over a 4-week period under double-blind conditions. Twenty-eight inpatients with a diagnosis of endogenous depression received either trazodone, imipramine, or placebo. Trazodone was significantly better than placebo and frequently better than imipramine according to analyses... | 383,704 | [
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0.3121268,
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0.03774529,
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0.191354,
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0.2021836,
-0.2493463,
0.07277837,
-0.06048556,
0.3076573,
-0.02219962,
... |
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