title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Nephritis in children and young adults with systemic lupus erythematosus and normal urinary sediment. | One male and seven female patients (aged 6 to 26 years) with systemic lupus erythematosus (SLE), normal urinalyses, and normal biochemical tests of renal function, had renal biopsies to determine if significant nephropathy existed. Several had active SLE in other body systems at the time, either clinically or as eviden... | 386,241 | [
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The occurrence of salmonella in waste water from Danish slaughterhouses. A quantitative study. | In waste water from 11 slaughterhouses, the occurrence of salmonellas were followed continually during a whole week. Thirty-eight samples out of 66 were contaminated. The mean concentrations of salmonellas varied between 0.9 and 668 per 100 ml. Only 4 different serotypes were found viz., S. agona, S. indiana, S. senfte... | 386,253 | [
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Isolation and mapping of plasmids containing the Salmonella typhimurium origin of DNA replication. | A purified EcoRI restriction endonuclease fragment that determines resistance to kanamycin and is incapable of self-replication was used to select autonomously replicating fragments from an EcoRI digest of a Salmonella typhimurium F' plasmid containing the chromosomal region believed to include the S. typhimurium origi... | 386,330 | [
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Reconstitution of RNase P activity from inactive RNA and protein. | RNase P preparations from Escherichia coli can be separated into RNA and protein by chromatography, in buffers containing 7 M urea, on Sephadex G-200, DEAE-Sephadex, or CM-Sephadex columns. Neither RNA nor protein components alone exhibits any RNase activity. RNase P activity can be reconstituted by mixing separated RN... | 386,349 | [
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Insertion and turnover of macrophage plasma membrane proteins. | The composition, insertion, and turnover of externally disposed proteins on the macrophage plasma membrane were analyzed. Cells labeled with [35S]methionine were incubated with the nonpermeant reagent trinitrobenzene sulfonic acid to introduce the trinitrophenyl moiety on free amino groups of externally oriented membra... | 386,350 | [
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Identification and characterization of a self-regulated repressor of translocation of the Tn3 element. | Gene fusions that bring expression of the lacZ gene under control of transcriptional and trnaslational signals within the transposable element Tn3 have been used to study regulation of Tn3-specified proteins. A gene encoding a 21,355-Mr peptide that represses translocation of Tn3 and acts at the level oquenced; amber, ... | 386,354 | [
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Enkephalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma. | By using the Coons indirect immunofluorescence technique, enkephalin-like immunoreactivity with a granular localization was observed in human adrenal medullary gland cells and pheochromocytomas. In two of the tumors and in a few adrenal gland cells, a somatostatin-like peptide could also be identified. Catecholamine ce... | 386,355 | [
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[Arteriographic findings in a Schipper's fracture at the shaft of the femur (author's transl)]. | This report on a Schipper's fracture at the shaft of the femur in a twelve-year old boy is preceded by a systematic tabulation of the various non-traumatic types of fracture and a general synopsis of stress fractures. At the time of a first exacerbation of pain which had been persisting for several weeks, the x-ray fil... | 386,474 | [
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[Craniofacial trauma. Value and methods of early treatment. 70 cases (author's transl)]. | The two essential problems posed by craniofacial trauma are assessed in the light of 70 collected cases. Firstly, the "time" of treatment. Immediate surgery by two teams, neurosurgical and maxillofacial, may be justified in the presence of craniocerebral lesions. This occurs rarely. The cranial problem is often explore... | 386,476 | [
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Mouse erythrocyte rosette formation by human lymphoid cell lines. | Lymphoid cell lines have been studied with respect to mouse erythrocyte rosette formation, a marker for B cells. Cells from six B-cell lines out of fifteen tested were able to form mouse erythrocyte rosettes. When this capacity was studied after neuraminidase pretreatment of the cells, it defined three groups of B lymp... | 386,483 | [
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Cold lymphocytotoxins in connective tissue disorders. | Sixty-eight patients with various connective tissue disorders, 5 relatives of patients and 26 members of staff from the Centre for Rheumatic Diseases were studied for the presence in their sera of cold lymphocytotoxic antibodies. Antibodies were found in 71 percent of patients with systemic lupus erythematosus, 27 per ... | 386,498 | [
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[Determination of auto-antibodies against spermatozoa after vasectomy and epididymectomy by indirect immunofluorescence (author's transl)]. | As a result of successful recanalization of the vas deferens, a low pregnancy rate has been observed. The formation of auto-antibodies is considered as cause. In vasectomized and epididymectomized rats, the presence of auto-antibodies against spermatozoa was proven by indirect immunofluorescence. After uni- and/or bila... | 386,595 | [
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[Twenty years of urology in a children's hospital (1954--1974). Together with an epicrisis of 101 children with bilateral anomalies of the urinary passages, operated on in the first year of life (author's transl)]. | This work encompasses a 20-year period, during which a urologist spent an important part of his time in a children's hospital, because of his conviction that attemps at effective treatment of urinary passage anomalies in childhood have a chance only when treatment is begun as early as possible. A report is presented on... | 386,596 | [
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Antireflux ureteroileal anastomosis: experimental technique. | A technique for ureteroileal anastomosis with an antireflux extraluminal seromuscular ureteral tunnel was evaluated in 9 dogs. Evidence will be presented to show that this approach is effective in preventing reflux while preserving the integrity of the renal units. | 386,598 | [
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[Principles of differential immunodiagnostics in tuberculosis and other pulmonary diseases (author's transl)]. | When differential diagnostics between tuberculosis, sarcoidosis, bronchial carcinoma and non-specific pulmonary diseases is not possible with clinical and laboratory methods, diagnosis may be often put by the aid of immunological methods. Differential diagnostics, usually, has not to delimit all these diseases one from... | 386,622 | [
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[Bacteriological aspects of trichomonal vaginitis (author's transl)]. | An analysis was made of the vaginal flora of 25 gynaecological patients with acute trichomomal vaginitis, with the view to elucidating the bacteriological situation. Eighty-four isolates, an average of 3.4 per patient, were taken and included a wide range of aerobic and anaerobic bacteria. - Obligate anaerobic species,... | 386,649 | [
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[Applicability of ultrasonic B-scan diagnosis to localisation of intra-uterine contraceptive devices (author's transl)]. | The types Dana super and Copper T intra-uterine devices (IUD) were reliably localised by ultrasonic B-scanning in 100 patients. Five dislocalisations were recorded and one erroneous interpretation in a case of uterus myomatosus. The method was found to be applicable to screening test and is recommended particularly for... | 386,650 | [
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[Comparative study of modifications in the immunoperoxidase and immunofluorescent methods of detecting human tissue immunoglobulins]. | The comparison of the data obtained by using different modifications of the immunoperoxidase and immunofluorescent methods for detecting immunoglobulins in intestinal tissues was made. The direct immunoperoxidase method was shown to allow the quantitative study of immunoglobulin-containing cells. The direct immunoperid... | 386,656 | [
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Double blind comparison between cimetidine and gefarnate in cases of duodenal ulcer. | Thirty outpatients suffering from duodenal ulcer of recent onset were given cimetidine 1 g/day or gefarnate 250 mg/day for 6 weeks in a double blind trial, randomly balances between the groups. Endoscopic assessment was carried out at 4 and 6 weeks; patients healed after 4 weeks were withdrawn from the trial. In all pa... | 386,698 | [
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Immunopathology of the glomerular changes in chronic pyelonephritis. | To investigate the presence of intraglomerular immunoprotein deposition in chronic pyelonephritis (CPN), 29 renal specimens from patients with various urological diseases were examined by immunofluorescence. The relationship between immunohistological findings and types of glomerular changes which were classified accor... | 386,707 | [
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Trends in suicide in Sweden 1749-1975. | Changes in the suicide rate in Sweden have been studied over the period 1749-1975. It has risen from about 2 per 100,000 inhabitants at the middle of the 18th century to about 20 per 100,000 during the period 1971-1975. Thus a more than tenfold increase is evident. From the non-standardized figures a real and substanti... | 386,716 | [
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The role of thromboxane A2 in endotoxin-induced aggregation of guinea-pig platelets in vitro. | Large concentrations of endotoxin lipopolysaccharides (LPS) E. coli O127:B8 and E. coli O26:B6 were needed for induction of platelet aggregation in citrated platelet rich plasma (PRP) from normal guinea-pigs. When guinea-pigs were actively immunized with LPS E. coli O127:B8 their PRP became more sensitive to the aggreg... | 386,740 | [
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Role of vasoconstrictor mechanisms in the control of left ventricular performance of the normal and damaged heart. | The effect on the left ventricle of changes in the state of the arterial vasculature is best identified by utilizing calculations of pulsatile rather than steady flow phenomena. Impedance is the most satisfactory term to describe this effect. The normal ventricle compensates for changes in impedance largely by changes ... | 386,761 | [
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Immunologic basis for the redefinition of malignant lymphomas. | As neoplasms of the immune system, lymphomas can be characterized by a variety of immunologic technics. These technics, used in conjunction with morphology and cytochemistry, have promoted the development of lymphoma classifications which relate more closely to our current understanding of the anatomy and function of t... | 386,778 | [
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Results of multiparameter studies of T-cell lymphoid neoplasms. | By application of combined structural and functional analyses, most lymphoid neoplasms may be categorized as of T- or B-cell origin. T lymphocyte neoplasms include types of acute and chronic lymphocytic leukemias, certain cutaneous and node-based lymphomas, and lymphomas of thymocytes (convoluted lymphocytic lymphomas)... | 386,780 | [
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Questions and replies: role of the collecting tubule in fluid, sodium, and potassium balance. | In terms of day-to-day regulation of fluid and electrolyte balance, the collecting tubule system appears to occupy a paramount position among segments of the renal tubule. Controversy has arisen concerning the quantitative contribution by the collecting tubule system to the regulation of individual solute excretion, wh... | 386,805 | [
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Change of T-lymphocyte ratio after keratoplasty. | Changes in the ratio of active and total E rosettes of 12 untreated and 26 corneal transplant patients with immunosuppressive therapy were examined weekly for a month and in the third month. On the basis of our results it can be stated that keratoplasty increases immune reactivity. This manifests itself in the increasi... | 386,821 | [
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Subepithelial fibrous tissue in failed corneal grafts. A histopathologic study. | Clinical observation of corneal grafts often reveals subepithelial whitish opacities or membranes. To further understand the phenomenon, we undertook a histopathologic study of the changes in this region in failed human corneal grafts. Thinning and thickening of the epithelium, breaks in Bowman's membrane, and growth o... | 386,822 | [
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0.0198928,
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0.1889954,
-0.009656549,
-0.08183811,
0.07227393,
0.07428031,
-0.1182... |
[Positive blood cultures in the "Centre des Brûles du c. h. u. de Lille". Evolution of epidemiology during the last thirteen years (author's transl)]. | An epidemiological study was made on 3,249 patients admitted in the "Centre des Brûlés du C.H.U. de Lille" from January 1965 to December 1977. This study showed that 7.1 per cent of these patients has one or more positive blood cultures. The main bacteria are staphylococcus aureus, streptococcus, pseudomonias aeruginos... | 386,856 | [
0.1508015,
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0.3445589,
0.2828674,
0.5322979,
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... |
Objective and subjective assessment of ephedrine combinations in asthmatic outpatients. | 11 asthmatic outpatients were treated with placebo, ephedrine + theophylline + hydroxyzine, ephedrine + theophylline, and ephedrine + hydroxyzine, orally t.i.d. for 4 days each in random order. Both objective (PEF rates) and subjective (ranking list) assessments demonstrated the efficacy of the triple combination over ... | 386,912 | [
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0.2256601,
0.1873199,
... |
[Sterol affinity of Candida albicans cells resistant to polyene antibiotics]. | The affinity levels of sterols in the sensitive and resistant cultures of C. albicans for polyenic antibiotics were studied comparatively. The affinity level was determined by liberation of potassium under the effect of the antibiotic participating in interaction with the sterol. The protective effect of the sterol sus... | 386,937 | [
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0.3333932,
0.5736131,
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[Ampicillin treatment trial in gonorrhea recurrences]. | The results of using ampicillin in treatment of 54 gonorrhea patients (41 males and 13 females) previously treated with other antibiotics without success are presented. Ampicillin was used in a daily dose of 500 mg administered 5 times a day at equal intervals and an 8-hour interval during the night time. The course do... | 386,940 | [
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... |
Biochemistry of intraerythrocytic parasites. I. Identification of enzymes of parasite origin by starch-gel electrophoresis. | Enzymes of parasite origin were identified by starch-gel electrophoresis. The species of parasite studied were Plasmodium berghei, Plasmodium yoelii nigeriensis, Babesia rodhaini and Anthemosoma garnhami. Lactate dehydrogenase, glucose phosphate isomerase and (NADP) glutamate dehydrogenase were detected in all species;... | 386,967 | [
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0.2475751,
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0.2777408,
0.1608832,
0.049... |
Abnormal haemoglobins in the Sudan savanna of Nigeria. II. Immunological response to malaria in normals and subjects with sickle cell trait. | Children born in areas hyperendemic for Plasmodium falciparum are protected by maternal antibodies for up to about five months of life, after which they are subject to intense infection until they acquire sufficient immunity--by about five years of age. Children with sickle cell trait (Hb.AS) are at an advantage during... | 386,969 | [
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0.3790306,
0.107808,
0.1879864,
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... |
Biochemistry of intraerythrocytic parasites III. Biochemical taxonomy of rodent Babesia. | Biochemical methods were investigated for use in taxonomic studies on Babesia. The techniques used were variation in the mobility of parasite enzymes on starch gels after electrophoresis and the measurement of the buoyant density of the DNA of the parasites. The study was carried out on four rodent species of Babesia (... | 386,972 | [
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0.1313908,
0.06560479,
0.06050803,
0.179239,
0.06626021,
0.003841... |
Ontogenic drug studies in calves. II. Changes in salicylate levels and metabolism in calves with diarrhoea. | Acetylsalicylic acid (ASA) was administered by oral route to calves and mice. A comparison of plasma levels of salicylates and salicyluric acid was performed in healthy and diarrhoic calves. The calves were infected with E. coli enterotoxin producing strains. During the 6 h observation period increased levels of salicy... | 387,046 | [
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0.132191,
0.2133228,
0.2926833,
-0.2066848... |
Radiosensitization of E. coli B/r by 9-anilinoacridines. | Six anilinoacridine derivatives have been tested for the ability to act as radiosensitizers. Two gave good sensitization at concentrations of 100 microM or less. Both of these are known to possess significant activity against experimental tumours, and one (m-AMSA) is in Phase II clinical trial as a chemotherapeutic dru... | 387,061 | [
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0.4341782,
0.2762052,
-0.04178343,
-0.05092316... |
Reduced leucocyte alkaline phosphatase activity and decreased NBT reduction test in induced iron deficiency anaemia in rabbits. | Iron deficiency anaemia was induced in rabbits by repeated bleeding. The leucocyte alkaline phosphatase (LAP) of 26 +/- 28 units was significantly reduced compared with control values of 233 +/- 35 units (P less than 0.001). Leucocyte NBT reduction was also diminished, both in Hanks solution (P less than 0.01) and in a... | 387,063 | [
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-0.277469... |
Affinity labeling of the 3'-OH terminal binding site of the ribonucleic acid chain on deoxyribonucleic acid dependent ribonucleic acid polymerase from Escherichia coli. | Nucleoside triphosphates modified at the 3'-OH are chain terminators for RNA polymerase. They form inactive ternary complexes with the enzyme, poly(dT), and oligoadenylate, the stabilities of which depend upon the length of the oligonucleotide. Employing [5'-32P]p(Ap)10A, together with the reactive analogues 3'-(bromoa... | 387,081 | [
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0.2475709,
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0.1004116,
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[Restoration of antineoplastic reactivity of the leukocytes after preincubation]. | Specific antitumor sensitization in patients with carcinoma of the stomach was revealed by means of the leukocyte migration inhibition test. After 24-hour preincubation at 4 degrees C in a serum-free medium the areactive leukocytes from patients with carcinoma of the stomach (stages III--IV) acquired the ability to rea... | 387,109 | [
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0.5367766,
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0.02169885,
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Cardiac tamponade resulting from pericardial extramedullary hematopoiesis: a case report and review of the literature. | A patient with an unusual myeloproliferative disorder, characterized by hepatosplenomegaly, myelofibrosis, ringed sideroblasts, and conversion to acute myeloblastic leukemia developed cardiac tamponade secondary to pericardia extramedullary hematopoiesis. Diagnostic criteria are discussed. Irradiation and systemic chem... | 387,207 | [
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0.01497886,
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Current concepts of bacteremia in children with malignancies. | One hundred fifteen episodes of bacteremia occurred among 2790 children with malignancies hospitalized during a 45-month period. The mean age was 9.3 years with a male predilection (62%). A greater (p less than .025) number of children over 10 years of age died with bacteremia when compared to younger children. The maj... | 387,211 | [
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Mode of DNA binding of cis-platinum(II) antitumor drugs: a base sequence-dependent mechanism is proposed. | Chloroammine and similar complexes of platinum(II) having the ammine ligands in the cis configuration are effective antitumor agents but the corresponding trans isomers are not. This is possibly due to the different manner in which these drugs attack DNA. There is considerable controversy in the literature over the typ... | 387,222 | [
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Toxic effects of cis-dichlorodiammineplatinum(II) in man. | Administration of cis-dichlorodiammineplatinum(II) may be associated with a number of serious side effects, including nephrotoxicity, gastroeintestinal side effects (nausea, vomiting, and diarrhea), myelosuppression, and occasional transient elevations in liver function tests. In addition, ototoxicity (tinnitus and hea... | 387,223 | [
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0.01713521,
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0.1929207,
0.1683875... |
Phase II trials with cis-dichlorodiammineplatinum(II) in the treatment of urothelial cancer. | Results of disease-oriented phase II trials with cis-dichlorodiammineplatinum(II) (cis-platinum) in 135 adequately treated patients with advanced urothelial tumors at Memorial Sloan-Kettering Cancer Center are presented. In four protocols which used cis-platinum alone or in combination with Adriamycin and/or cyclophosp... | 387,226 | [
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Research related to medical treatment of cardiovascular disease. | Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics ... | 387,290 | [
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Assay of theophylline: comparison of EMIT on the ABA-100 to HPLC, GLC and UV procedures, with detailed evaluation of interferences. | The EMIT technique for theophylline measurement as adapted to the Abbott Bichromatic Analyzer (ABA-100), was compared to two other established procedures. EMIT results correlated well with those obtained with high pressure liquid chromatographic (HPLC) (r = 0.995, N = 54) and spectrophotometric (UV) (r = 0.95, N = 37) ... | 387,295 | [
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0.2500114,
0.4224768,
0.0773632,
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... |
Shigella infections. | Shigellosis is a complex disease involving two distinct organs and two distinctive clinical presentations of intestinal involvement. It is also associated with a wide variety of extra-intestinal manifestations. Because these may precede the onset of diarrhoea/dysentery, and confuse the diagnosis, it is safe to denote s... | 387,300 | [
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0.3251278,
0.1001623,
0... |
Hormonal control of implantation in the rat: inhibition by luteinizing hormone-releasing hormone and its analogues. | Chronic treatment of pregnant rats with luteinizing hormone-releasing hormone (LH-RH) and its analogues (Analogue I: des-Gly10-LH-RH-ethylamide; Analogue II: des-Gly10-[D-Ala6]-LH-RH-ethylamide) inhibited implantation of the ovum. Analogues I and II were 4.5 and 173 times potent than native LH-RH in inhibiting implanta... | 387,353 | [
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0.2022023,
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0.109... |
Comparison of a new hypnotic (Finorgal) with placebo in a double-blind trial. | The hypnotic effects of Finorgal (ethchlorvynol with diphenhydramine) were compared with those of placebo in a double-blind study with crossover of treatments in thirty-five hospital in-patients. During the four-week period of Finorgal treatment there was a significant reduction in the mean time elapsing between the ad... | 387,492 | [
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0.06916317,
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0.03398908,
-0.1960... |
Hydrocortisone alcoholic solution in eczematous external otitis. | A double-blind, randomized study is described involving a total of fifty-five patients suffering from eczematous external otitis comparing for efficacy hydrocortisone alcoholic solution and hydrocortisone-17-alpha-butyrate. The trial duration was seven days. No difference in efficacy could be demonstrated between the t... | 387,497 | [
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0.2083959,
0.07990254,
0.1699002,
0.04... |
Thermo-inducible expression of cloned early genes of bacteriophage Mu. | An EcoRI fragment, containing approx. 5100 base pairs (bp) of the immunity-end of bacteriophage Mu, was inserted into the multicopy plasmid pMB9 by in vitro recombination. The expression of early Mu genes, located on the cloned fragment, is thermo-inducible because of the presence of the ts mutation in gene c. The isol... | 387,527 | [
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0.1491646,
0.337137,
0.07602108,
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Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls. | Heat-killed whole BCG cells (KC) and BCG cell walls (CW) were each tested in emulsified form for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basis, KC were at least as effective as CW in causing tumor regression and elimination of microscopic lymph node metastasis, and they, as ... | 387,592 | [
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0.0687202,
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... |
Inhibition by human serum of lymphocyte proliferation stimulated by purified protein derivative of tuberculin and bacillus Calmette-Guérin. | The addition of normal human serum to murine lymphocyte cultures consistently depressed mitogen-induced transformation, as measured by deoxyribonucleic acid synthesis. Stimulation by the B-cell mitogens purified protein derivative-tuberculin, bacillus Calmette-Guérin, and lipopolysaccharide was consistently affected, b... | 387,593 | [
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0.1229787,
0.2978831,
0.3281311,
0.07794655,
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... |
Surgical treatment of grade IV patellar luxation in the neoambulatory dog. | A wire-suture method was used for correcting grade IV medial and lateral luxations of the patella. In seven operated stifles, the method resulted in a normal gait and minimal valgus and varus deformity of the distal femur and proximal tibia. | 387,682 | [
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-0.4270003,
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-0.1169868,
-0.09367622,
-0.1106812,
0.2755528,
-0.2863598,
-0.1630184,
-0.2247436,
0.05650026,
0.09536316,... |
Antifungal activity upon Saccharomyces cerevisiae of iturin A, mycosubtilin, bacillomycin L and of their derivatives; inhibition of this antifungal activity by lipid antagonists. | The antifungal activity of three antibiotics of the iturin group: iturin A, mycosubtilin, bacillomycin L and of eleven methylated and acetylated derivatives of these antibiotics was tested upon Saccharomyces cerevisiae. The lowest MIC values were found for natural antibiotics. The substitution of polar groups diminishe... | 387,691 | [
0.1033748,
0.3666523,
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0.1525093,
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0.2545205,
0.2072618,
0.2093506,
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-0.... |
An in vitro evaluation of clavulanic acid, a potent, broad-spectrum beta-lactamase inhibitor. | The in vitro efficacy of clavulanic acid, a new broad-spectrum inhibitor of enterobacterial beta-lactamases, was investigated. In conventional agar dilution tests, the presence of a sub-inhibitory level of clavulanic acid (8 microgram/ml) lowered the minimum inhibitory concentration of ampicillin for many resistant ent... | 387,706 | [
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0.1835061,
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0.2595867,
0.3737682,
-0.01921166,
0.2973263,... |
Pyridine nucleotide cycle of Salmonella typhimurium: in vitro demonstration of nicotinamide mononucleotide deamidase and characterization of pnuA mutants defective in nicotinamide mononucleotide transport. | The enzyme nicotinamide mononucleotide deamidase, an integral component of the proposed four-membered pyridine nucleotide cycle (PNC IV), has been demonstrated in extracts of Salmonella typhimurium LT2. The enzyme has an optimum pH of 8.7 and deamidates nicotinamide mononucleotide, forming nicotinic acid mononucleotide... | 387,742 | [
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0.06889883,
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0.3446704,
0.08699905,
-0.0198112... |
Polyamine biosynthesis during germination of yeast ascospores. | The role of the diamine putrescine during germination and outgrowth of ascospores of Saccharomyces cerevisiae was examined. Ornithine decarboxylase activity increased and declined rapidly during germination and outgrowth; peak activity was attained after the cells had proceeded through the G1 interval of the cell cycle... | 387,744 | [
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0.09059564,
0.8677225,
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0.0240853,
0.1... |
T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. | Bacteriophage T7-induced DNA polymerase has been isolated by a procedure suitable for large scale use and which yields near homogeneous enzyme. In addition to previously described DNA polymerase activity and 3' to 5' exonucleolytic activity on single stranded DNA (Grippo, P., and Richardson, C. C. (1971) J. Biol. Chem.... | 387,776 | [
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0.004234545,
0.01242456,
0.1435858,
0.05919318,
-0.0235942... |
Bacteriophage fd gene II-protein. II. Specific cleavage and relaxation of supercoiled RF from filamentous phages. | Bacteriophage fd gene II-protein was characterized as an endonuclease which specifically nicked supercoiled replicative form (RF) of filamentous phages in the viral strand. No other supercoiled DNAs tested were attacked by the enzyme, nor were doubly closed fd RF in the relaxed state nor phage fd single strands. Maxima... | 387,792 | [
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0.0003554247,
0.3334004,
0.1136479,
-0.26232... |
Characteristics of noncultivable adenoviruses associated with diarrhea in infants: a new subgroup of human adenoviruses. | Virus particles morphologically resembling adenovirus were found in fecal specimens from infants and were examined for cultivability with standard cell culture techniques and for characteristics of human adenoviruses. Specimens from 13 of 15 infants could not be cultivated in cell cultures. The two adenoviruses that we... | 387,812 | [
-0.2441249,
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0.01799833,
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0.1888243,
0.351523,
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... |
Antigen requirements, sensitivity, and specificity of enzyme immunoassays for measles and rubella viral antibodies. | Enzyme immunoassay (EIA) systems for measles virus and rubella virus were studied from the standpoints of requirements for suitable viral antigens and control antigens, and the sensitivity and specificity of the tests for detecting antibody elicited by past infection (determination of immunity status), and for serodiag... | 387,813 | [
-0.1965831,
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0.5400187,
0.6409347,
-0.2329377,
-0.2590523,
... |
Microstructures in non-precious alloys near the procelain-metal interaction zone. | The chemistry of microstructures near the interfacial reaction zones of four non-precious alloys and two different brands of dental porcelain has been analyzed. It was found that most non-precious dental alloys contain second phases which can alter elemental concentration profiles. Recommendations for assessing interfa... | 387,836 | [
-0.226452,
0.4692532,
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0.1140619,
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0.1429053,
-0.29... |
Taxonomy of Clostridium tetani and related species. | Clostridium tetani and its related species C. tetanomorphum, C. cochlearium and C. lentoputrescens were examined for DNA-DNA homology and biochemical properties. Two distinctly different groups were included under the name of C. tetanomorphum: one was identical with C. cochlearium and the name C. tetanomorphum was appl... | 387,912 | [
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0.07624429,
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0.4013208,
0.2432449,
-0.0586777,
... |
Surgical-orthodontic correction of horizontal maxillary deficiency. | Selected maxillary osteotomies in concert with rapid maxillary expansion appliances are dependable adjuncts to treatment of the various clinical manifestations of horizontal maxillary deficiency and the accompanying crossbite. The important diagnostic, treatment planning, and technical considerations necessary for succ... | 387,931 | [
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0.2719141,
-0.1171239,
-0.036... |
Immunological studies in thymectomized and non-thymectomized patients with myasthenia gravis. | Eleven thymectomized and ten non-thymectomized patients with myasthenia gravis, matched with respect to sex, age, duration and severity of the disease were investigated with respect to routine clinical features, electrophysiological examination, HLA-typing, auto-antibodies, lymphocyte subpopulations in peripheral blood... | 387,958 | [
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0.2242668,
0.203533,
0.07370194,
-0.05088127,
... |
Immune complexes in newly diagnosed insulin-dependent (type I) diabetics. | Soluble immune complexes (AgAb) and islet cell antibodies (ICAb) were studied in 110 insulin dependent diabetics (IDD) within a week of diagnosis and in about a third of the patients after 1, 3, 6 and 12 months. AgAb were studied by the solid phase Clq binding test in all the patients and also by the Raji cell radioimm... | 387,959 | [
0.05251147,
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0.1686583,
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0.2500535,
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0.1125033,
0.1348812,
0.3891752,
0.3066223,
-0.001503129,
... |
Evolution of defective-interfering double-stranded RNAs of the yeast killer virus. | We have characterized by T1 fingerprint analysis several defective interfering (DI) double-stranded RNAs of the simple yeast virus ScV. A common sequence of about 0.5 to 0.6 kilobase pairs, including both 3' termini of the parental RNA, was present in each DI RNA. Several DI RNAs had novel T1 oligonucleotides not prese... | 387,980 | [
0.0973124,
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0.1052856,
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... |
[Clinical evaluation of cefamandole in infants and children (author's transl)]. | Clinical trials were carried out with cafamandole (sodium salt) in pediatric infections. Results were as follows; 1. CMD was applied to 13 patients with pneumonia, 1 patient each with submandibular abscess, urinary tract infection and bacterial meningitis. 2. Results were excellent in 1 and good in 13 patients, being o... | 387,995 | [
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0.2638823,
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0.09763724,
... |
Serum luteinizing hormone and ovulatory response to luteinizing hormone-releasing hormone in the estrous and anestrous domestic cat. | A heterologous double antibody radioimmunoassay was developed to measure changes in serum luteinizing hormone (LH) concentrations in estrous and anestrous queens (female domestic cats), following a single injection of varying doses (0--25 microgram) of luteinizing hormone-releasing hormone (LH-RH). No increase in serum... | 388,071 | [
0.08387869,
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0.00354904,
0.2697502,
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... |
Cathepsin B activity in stimulated mouse peritoneal macrophages. | The activity of cathepsin B was assayed in murine resident peritoneal macrophages, and after stimulation of the cells in vivo and in vitro. The resident cells showed a very low activity of the enzyme, compared to the activities of three other lysosomal enzymes: cathepsin D, acid phosphatase, and beta-glucuronidase whic... | 388,072 | [
0.001380964,
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0.3693593,
0.3153659,
0.301854,
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... |
Integration of temperature-sensitive nonconjugative plasmid carrying kanamycin gene into conjugative R plasmids. | A nonconjugative R plasmid, rMS3, whose molecular weight was 2.4 X 10(7) daltons, possessed a kanamycin resistance gene and was thermosensitive in its maintenance in Escherichia coli strains. We mobilized rMS3 with a conjugative R plasmid, R100 or T-tet, and obtained cointegrates carrying all the parental resistance ma... | 388,158 | [
0.04556683,
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0.2107573,
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0.04817161,
... |
Hodgkin's disease. | During the past two decades, new approaches to the diagnosis and treatment of Hodgkin's disease have contributed to improved rates of survival and probable cure. Currently, patients with Hodgkin's disease are treated according to the stage and symptoms of their disease. The degree of certainty necessary for determining... | 388,217 | [
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... |
Why are enzymes macromolecules? | The possible reasons for the macromolecular nature of enzymes are discussed. They are recognized in the necessity of creating a highly specific stereochemistry and microenvironment in the active site, in the necessity of maintaining the protein conformational rigidity, its fit with the physiological environment and ove... | 388,239 | [
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0.2062899,
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Vasoactive intestinal polypeptide nerves in human upper respiratory tract. | Immunoreactive vasoactive intestinal polypeptide (VIP), a recently recognized neuropeptide with a possible transmitter function has been demonstrated in nerves of the human upper respiratory tract. VIP nerves predominate in the inferior turbinate of the nose and in the tracheal wall. They are distributed in the subepit... | 388,276 | [
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... |
[Action of methicillin on the synthesis of surface protein A and type antigen 18 in Staphylococcus aureus]. | Staphylococcus aureus methicillin resistants strains cultivated on subinhibiting methicillin concentrations are not modified as concern protein A and type antigen 18. Low protein A production of these resistant strains known to be heterogenous as concern their resistance to methicillin does not correspond to absence of... | 388,301 | [
0.04854504,
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0.2820774,
0.3989238,
-0.06812665,
-0.170891... |
[Breast cancer: a dynamic approach of cellular immunity and immunostimulation with an immunoadjuvant: P40 fraction. (author's transl)]. | The study of the immune status of breast cancer patients with delayed hypersensitivity skin tests reveals a clear immune deficiency in comparison with a reference patients group. This immunstatus was significantly improved by an immunstimulation with the P40 fraction. The responsive capacity to an immunstimulation appe... | 388,318 | [
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0.06911889,
0.06610069,
0.3640348,
0.5275092,
-0.04191333,
0.132... |
Protease inhibitors in human milk. | Protease inhibitors (inhibiting trypsin, chymotrypsin, and elastase) were demonstrated in human milk from birth to 4 months after delivery. No pepsin inhibitor was found. The protease inhibitors were localized in the alpha 1-region--inhibiting trypsin, chymotrypsin, and elastase--and in a more cathodal region--inhibiti... | 388,334 | [
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0.09037863,
0.2264276,
-0.1109183,
... |
Is UAA or UGA part of the recognition signal for ribosomal initiation? | In none of the 92 published prokaryotic sequences is a translation codon preceeded by UAG as the first "termination codon". In most cases the UAA or UGA is close to the initiation codon and may be part of the ribosome recognition signal. | 388,349 | [
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... |
Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from Escherichia coli. | Limited tryptic digestion of the pyruvate dehydrogenase complex of Escherichia coli or its dihydrolipoyl transacetylase core cleaves the trypsin-sensitive transacetylase subunits into two large fragments, A (lipoyl domain) and D (subunit binding domain). Release of fragments A from the complex does not significantly af... | 388,441 | [
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0.1356498,
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0.2766618,
-0.07847711,
... |
[Salmonella colitis]. | Salmonella colitis is defined on the basis of 3 case reports and 75 well-documented cases from the literature. Salmonella colitis is an acute ulcerative colitis occurring in enteric salmonellosis. There is complete clinical and endoscopic remission within 4--8 weeks and no relapse. The disease is to be distinguished fr... | 388,615 | [
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0.03529228,
0.02247912,
-0.06042028,
-0.01... |
Epidemiology of Shigella dysenteriae, type 1 infections, in Dacca urban area. | A prospective study of 47 families with an index case of Shigella dysenteriae type 1 was conducted in the urban areas of Dacca. The subsequent infection rates in contacts type 1 were 30.6% and 28.3% in the age groups 0--4 and 5--9. Total secondary infection rate was 20.4% with rates in males higher than in females. Amo... | 388,775 | [
0.06676315,
-0.2870137,
0.4191561,
0.1005598,
-0.04110719,
-0.2103338,
-0.3611626,
-0.2221546,
0.004535481,
0.2074006,
0.342658,
0.2536972,
-0.1259776,
0.3769871,
-0.008692668,
-0.3874228,
-0.2083602,
-0.06854686,
0.03164522,
-0.3038243,
0.3871506,
0.005180968,
-0.0832349... |
[Acute cholelithiasic intestinal obstruction]. | The paper presents the data of diagnosis, clinical picture and surgical treatment of 8 patients with acute cholelythic ileus. The authors describe the specific features of the clinical course of the disease and emphasize high diagnostic value of general rentgenography of the abdomen for the recognition of this complica... | 388,818 | [
0.1077666,
-0.03340419,
-0.1715286,
-0.2283195,
0.2062621,
0.009808464,
-0.1875901,
-0.3093636,
0.1290474,
0.1130574,
0.1777837,
0.0007839947,
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-0.3701954,
-0.1862822,
-0.4315521,
0.2125873,
0.1087938,
0.04574874,
0.2879453,
0.1352296,
-0.1092415,
... |
Colicin receptors and the mechanisms of colicin uptake. | This review deals in detail with the nature, synthesis, physiologic functions, and the regulation of colicin receptors, which represent components of transportsystems, as well as with the two mechanisms of the colicin uptake within the groups A and B of colicins. | 388,937 | [
-0.1180002,
-0.0432913,
-0.1114258,
0.1233377,
-0.0149237,
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-0.3836909,
-0.003388122,
-0.002364971,
0.1623056,
0.2140475,
-0.03131957,
0.02763424,
0.1427046,
-0.5421827,
-0.2348681,
-0.3644472,
-0.1334516,
-0.2503103,
-0.1517392,
0.3759215,
0.1704801,
-0.178785... |
Immunoelectron microscopic localization of T proteins in the cell wall of Streptococcus pyogenes. | T proteins of Streptococcus pyogenes (group A streptococci) were localized by means of immunochromatographical isolated anti-T-antibodies. For the electron microscopical detection both the direct and the indirect immunoferritin techniques were used. The arrangement of the ferritin particles showed, that the T proteins ... | 388,938 | [
0.1520786,
-0.08002917,
-0.2431054,
0.3103577,
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-0.06701113,
0.06574637,
0.3176859,
0.1138342,
0.2357042,
0.1884438,
0.2387097,
-0.1095952,
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-0.1766313,
-0.08780704,
-0.05118468,
-0.01377907,
0.3816687,
0.3194711,
-0.2395012... |
Blood cultures with the BACTEC 225 radiometric microbial growth detection system. | The BACTEC 225 automated radiometric blood culture system was compared with a conventional blood culture bottle method for its ability to improve the rapid laboratory diagnosis of bacteremia in cancer patients. The BACTEC 225, in combination with routine blind subcultures and smears of radiometrically negative culture ... | 388,943 | [
-0.1084098,
-0.1429158,
-0.207769,
-0.1992093,
-0.2414471,
-0.04846033,
-0.2913677,
0.1128487,
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0.06698222,
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0.2623039,
-0.3879084,
0.192815,
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-0.1330985,
-0.0983983,
0.2450719,
-0.321871,
0.09855055,
0.5304003,
0.2218058,
0.3186014,
0... |
Isolation of Francisella tularensis from mites Haemogamasus nidi and Laelaps hilaris in western slovakia. | Isolating of F. tularensis from gamasid mites H. nidi parasitizing on the bank vole (Cl. glareolus) and L. hilaris on the common vole (M. arvalis) are reported. The epidemiological significance of this finding is discussed. | 388,944 | [
-0.2887607,
0.008091733,
-0.007783119,
-0.1988651,
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-0.3579243,
-0.1965126,
-0.4582365,
0.003515657,
0.4594809,
0.1818431,
0.07065587,
-0.1520253,
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-0.0845608,
0.09407528,
0.2848072,
0.004421278,
0.4097657,
0.200987,
-0.178774... |
Different appearance of parasitized erythrocytes in blood between normal and toxoplasma-infected rats after infection of Plasmodium berghei. | When normal rats were infected with Plasmodium berghei (Pb), both IgG and IgM immunofluorescent antibody titers were found to rise in the 1st week with increase of parasitaemia. After reinoculation of P. berghei into Pb-immune rats, IgG titer was further increased remarkably, although no parasitaemia was observed. No e... | 388,945 | [
0.01686137,
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0.08096113,
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0.2482471,
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0.01004178,
0.2400243,
0.3621558,
0.04393509,
0.1289052,
-0.2021066,
-0.1196695,
-0.4487483,
-0.1403319,
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0.3739601,
-0.161989,
0.2956664,
0.05396809,
-... |
Measurements of cardiac output and organ blood flow in rats using 99Tcm labelled microspheres. | The cardiac output and regional blood flow have been simultaneously determined in the anesthetized rat by using the reference organ method. 99Tcm labelled dextran 15 micron microspheres were injected in the left ventricle while simultaneously an arterial reference sample was drawn at constant known rate. The values cal... | 388,984 | [
-0.3224321,
-0.0124075,
-0.3441503,
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0.05154962,
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-0.06986266,
0.2314583,
0.06740011,
0.09175062,
-0.1581339,
-0.5570075,
-0.09404584,
-0.3485349,
-0.02734682,
-0.09376626,
0.345582,
0.307851,
0.08854183,
0.157459... |
Effects of differences in amount and kind of dietary carbohydrate on plasma glucose and insulin responses in man. | The effect of variations in kind and amount of dietary carbohydrate on plasma glucose and insulin responses was studied in normal subjects and in patients with chemical diabetes. Plasma glucose and insulin responses fell when the proportion of total calories given as carbohydrate were decreased by 15% (coincidental wit... | 389,023 | [
0.03839692,
0.3323332,
-0.2190346,
-0.01009258,
-0.02647741,
-0.4597493,
-0.1755944,
0.5390961,
0.1594332,
0.3600799,
0.1114793,
-0.1398019,
-0.1696486,
-0.1400114,
-0.4265237,
-0.1481493,
0.02416199,
0.08276028,
0.006155004,
0.0957109,
0.1428432,
0.332485,
-0.1223882,
... |
The psychiatric use of electrically induced seizures. | ECT is an effective but also controversial treatment modality in psychiatry. The decision of when to use ECT is predicated on a knowledgeable assessment of anticipated benefits and possible risks as they apply to each individual case. Refinements in ECT technique have minimized risks, but have also increased the method... | 389,068 | [
-0.2748392,
0.1145759,
-0.2736552,
-0.4023504,
0.2349511,
-0.1843061,
-0.3905567,
-0.3438842,
-0.2090366,
0.04226528,
0.003766372,
0.3048783,
-0.129014,
0.1574606,
0.01720693,
-0.2144454,
-0.2115895,
0.3112495,
-0.05408207,
-0.04496736,
0.0049275,
0.1275053,
-0.0195967,
... |
[Review of in vitro feeding of bloodsucking anthropods]. | A review on methods of in-vitro-feeding of bloodsucking arthropods is given. The most important sphere of application of these methods are the in-vitro-rearing, experiments of transmission of virulent and avirulent pathogens, investigations about the nutrition of haematophagous arthropods, and about the efficiency of p... | 389,101 | [
-0.1338351,
0.07192849,
-0.1694544,
-0.01388873,
-0.1669787,
-0.09997232,
-0.3761578,
0.007993035,
0.1006821,
-0.187415,
0.2378413,
0.01320348,
0.04718814,
-0.2710571,
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-0.03527943,
-0.5839067,
0.02984852,
-0.1510064,
0.2904617,
0.2206935,
0.156158,
0.01316459,... |
Equine Escherichia coli endotoxemia: comparison of intravenous and intraperitoneal endotoxin administration. | Certain physiologic and hematologic data were determined in ponies given Escherichia coli endotoxin by three routes: single IV dose, single intraperitoneal (IP) dose, and multiple IP boluses. In all ponies, the reaction was characterized by weakness, depression, peripheral circulatory abnormalities, and pyrexia. The py... | 389,113 | [
0.04856374,
-0.3124443,
-0.2861633,
-0.2303102,
0.1356512,
-0.5928172,
0.2420728,
0.06426689,
-0.7325115,
-0.09202877,
0.1358214,
-0.3439583,
-0.183527,
0.08576857,
-0.2339717,
0.1004226,
-0.5689958,
-0.04878686,
0.04138251,
0.2875044,
-0.08080168,
0.2523347,
0.07203345,
... |
Identification of tubercle bacilli. | Initial screening of tubercle bacilli with 2-thiophene carboxylic acid hydrazide (TCH) or 2-furoic acid hydrazide (FAH) separates them into two groups. Resistant strains are Mycobacterium tuberculosis. Sensitive strains include M. tuberculosis, M. bovis and BCG which are separated by nitratase and oxygen requirement te... | 389,130 | [
-0.04176974,
-0.06595913,
-0.08105368,
0.04383079,
-0.048263,
-0.3071079,
-0.4322679,
0.09339448,
0.03223072,
-0.4570892,
0.1577965,
0.01844445,
0.08435658,
0.1607793,
-0.3924197,
-0.2338237,
-0.3960497,
0.2695164,
0.1511747,
0.01473414,
0.08707526,
0.4195935,
-0.3033819,... |
[Inhibition of Escherichia coli haemagglutinations by antibiotics]. | Escherichia coli has been associated with a colonization factor antigen responsible for the bacterial adherence to the intestinal mucosa. This colonization factor is also responsible for haemagglutination. Among 32 antibiotics tested, only tetracyclines, chloramphenicol and nafcillin inhibit haemagglutination. Tetracyc... | 389,131 | [
-0.1012407,
0.00537509,
-0.008062895,
-0.1017883,
0.1680861,
-0.3900116,
-0.1274479,
-0.07743697,
-0.02392105,
-0.2872592,
0.2018424,
0.06560063,
0.03585342,
0.07398359,
-0.53611,
-0.2753858,
-0.5220712,
-0.2455573,
-0.2927689,
0.07723378,
0.02946672,
-0.1133699,
-0.17524... |
[Doxycycline bioavailability in capsules]. | Soviet doxycycline capsules in a dose of 0.1 g were studied in vitro (for disintegration and solubility) and in vivo (pharmacokinetics on 25 patients). It was found that Soviet doxycycline capsules provided comparatively rapid absorption of doxycycline. The antibiotic availability may be characterized by the solubility... | 389,153 | [
-0.2536811,
0.1244401,
0.1196886,
-0.01977647,
-0.2220286,
-0.09356716,
-0.2161984,
0.08019333,
0.1131906,
-0.4068764,
0.232216,
0.05669563,
0.2124436,
0.06431564,
-0.5802869,
-0.3180556,
-0.4787792,
-0.1092521,
-0.5283332,
0.1679606,
0.4555719,
-0.08807404,
-0.06815017,
... |
Acid hydrolases in experimental and spontaneous bullae. | The activities of eight acid hydrolases have been measured in blister fluid from various bullous disorders and from experimental suction blisters. The levels of all enzymes increased dramatically for at least 24 h after induction of the blister. No correlation was found between acid hydrolase activity and any individua... | 389,177 | [
-0.09244504,
-0.2565997,
-0.3416056,
-0.09381448,
0.01382094,
-0.1327657,
-0.12236,
-0.02137048,
-0.07912063,
-0.05201843,
-0.01086684,
0.01554507,
0.004380504,
-0.1404918,
-0.2601041,
0.01494109,
-0.2939247,
-0.1055216,
0.04061775,
0.2323883,
0.2555399,
0.327912,
-0.1206... |
Nesidioblastosis and congenital neuroblastoma: a histologic and immunocytochemical study of a new complex neurocristopathy. | Congenital neuroblastoma and nesidioblastosis occurred simultaneously in a neonate with severe hypoglycemia. This combination may represent a rare type of complex neurocristopathy. Immunocytochemical staining revealed a diffuse proliferation of alpha, beta, and delta cells as clusters and individual cells. The total is... | 389,194 | [
-0.2766624,
-0.1535337,
-0.1298858,
-0.2007547,
0.1521659,
-0.3964018,
-0.3235477,
0.06312457,
0.309782,
0.2991717,
0.02380237,
0.04677533,
-0.09806685,
-0.1651866,
-0.1155846,
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-0.1709232,
0.06618923,
0.2388386,
-0.004709776,
0.3275824,
-0.03827764,
0.01453252... |
Transplantation of cultured bovine corneal endothelial cells to species with nonregenerative endothelium. The cat as an experimental model. | The in vivo transplantation of cultured bovine corneal endothelial cells has been attempted in the cat. Cat corneas denuded of their endothelium were coated with bovine corneal endothelial cells previously maintained in tissue culture. When grafted back into cat recipients, the corneal buttons remained clear with no ed... | 389,220 | [
-0.2300508,
0.2287905,
-0.2058605,
0.03320206,
-0.09830639,
-0.1019857,
0.2264175,
-0.01187888,
0.1612364,
0.06934641,
0.2871515,
0.006791545,
-0.2644091,
0.1910659,
-0.5118839,
0.1705909,
-0.483148,
0.112893,
-0.1385823,
-0.113917,
0.02701099,
0.5051684,
0.1422081,
-0.... |
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