title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Study of pole assembly in Bacillus subtilis by computer reconstruction of septal growth zones seen in central, longitudinal thin sections of cells. | The septal growth of Bacillus subtilis 168/s has been studied by making a number of observations from thin sections of cells from exponentially growing cultures. The process was initiated by the formation of a new cross wall under a preexisting layer of cylindrical wall. An annular notch appeared to cut through the ove... | 415,053 | [
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Catabolic conversion of sepiapterin to 6-(1-carboxyethoxy)pterin by Bacillus subtilis. | Structural elucidation of an intensely blue fluorescent compound (A) formed from sepiapterin by Bacillus subtilis is described. The structure of the catabolite (A) was found to be 2-amino-6-(1-carboxyethoxy)-4(3H)-pteridinone (9) from both spectroscopic and degradation studies. This was confirmed by an unambiguous synt... | 415,056 | [
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Effects of repeated ingestion of large quantities of acetylsalicylic acid on membranous bone growth and dentin apposition in young monkeys. | Four daily doses of ASA were administered by mouth to young growing monkeys which received six injections of lead acetate every seven days as an intravital stain to indicate sites of bone and dentin mineralization. Microscopic evaluation of the inhibitory effects on membranous bone growth and dentin apposition was made... | 415,081 | [
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The effects of severe keratitis on corneal transmission. | An investigation into the effects of keratitis on corneal light transmission is presented. Transmission data from 9 diseased corneas are compared to those of 22 normal corneas in the 0.3-0.8 micron spectral range. Rhesus monkey corneas were used in the study. Several color photographs illustrate varieties of idiopathic... | 415,084 | [
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Evaluation of commercially prepared vaccines for experimentally induced type A/New Jersey/8/76 influenza virus infections in mice and squirrel monkeys. | Mice and squirrel monkeys were vaccinated and subsequently challenged at selected times to evaluate the immunoprophylactic value of vaccines against influenza virus type A/New Jersey/76. Mice were challenged with virulent, homologous virus either 17 or 60 days after vaccination with 80 chick cell-agglutinating (CCA) un... | 415,092 | [
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Expression of a single major histocompatibility complex locus controls the immune response to poly-L-(tyrosine, glutamic acid)-poly-DL-alanine-poly-L-lysine. | Genetic control of the immune response linked to the major histocompatibility (H-2) complex in the mouse has been described for synthetic polypeptide antigens and for low doses of native proteins. The phenomenon is well documented(1,2). Extensive screening of intra-H-2 crossover-derived recombinant strains has localize... | 415,111 | [
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Tubulin and microtubule-like structures in mammalian acrosomes. | Immunofluorescence and electron microscopy were used to demonstrate the presence of tubulin and microtubule-like structures in rabbit and rhesus monkey sperm acrosomes. The distribution of tubulin within the acrosome appeared similar to the distribution of proteolytic activity, suggesting an association of proteinase w... | 415,112 | [
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Studies on the mechanism of renin release from isolated superfused rat glomeruli: effects of calcium, calcium ionophore and lanthanum. | 1. The effects of external medium calcium concentration, the ionophore A(23187) and lanthanum on the rate of renin release in vitro were studied with particular emphasis on results obtained from isolated superfused glomeruli of rat kidneys.2. The response to reduction in superfusate calcium concentration from 2 mM was ... | 415,132 | [
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Sporadic (nonepidemic) puerperal mastitis. | Sporadic puerperal mastitis is an acute cellulitis, characterized by fever and segmental erythema in the breast. Staphylococcus aureus can be cultured in approximately one-half of the cases. With early antibiotic therapy, the infection can be cleared and abscess formation prevented. Breast engorgement may also contribu... | 415,137 | [
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Reduced Fc-receptor bearing cells in peripheral bloods of patients with systemic lupus erythematosus and in rheumatoid synovial fluids. | Previous reports described that human red cells sensitized with one of Rh antisera (Ripley) make rosette formations (Fc-rosette with some lymphocytes. These Fc-rosettes were well inhibited by aggregated human IgG as well as hypocomplementemic systemic lupus erythematosus (SLE) sera and rheumatoid synovial fluids. In th... | 415,139 | [
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Meningococcemia presenting as acute polyarthritis. | Four patientw with acute polyarthritis due to meningcoccemia are described. One had skin manifestations suggesting vasculitis, another had transient nodular lesions, but there were none of these features in the other two. Synovial fluid cultures were negative and cells counts did not suggest septic arthritis. The diagn... | 415,140 | [
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Diagnostic evaluation of hypertension: pilot study in a hypertension clinic. | Two hundred and eighty-two (282) patients suffering from hypertension were evaluated for the detection of secondary forms of hypertension. Apart from clinical and routine laboratroy investigation in each, straight film of abdomen, intravenous pyelography (IVP), isotope renography and aortography were done in 174, 51, 1... | 415,157 | [
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Consumer-Choice Health plan (second of two parts). A national-health-insurance proposal based on regulated competition in the private sector. | Medical costs are straining public finances. Direct economic regulation will raise costs, retard beneficial innovation and be increasingly burdensome to physicians. As an alternative, I suggest that the government change financial incentives by creating a system of competing health plans in which physicians and consume... | 415,241 | [
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Coupling of lac mRNA transcription to translation in Escherichia coli cell extracts. | In an extract containing all the components for lac gene expression except washed ribosomes, lac mRNA formation was increased 4- to 6-fold by the addition of washed ribosomes. The formation of beta-galactosidase mRNA and enzyme showed very different dependency on added ribosomes. Enzyme was formed in proportion to the ... | 415,305 | [
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Effects of d-amphetamine and ethanol on responding of squirrel monkeys maintained under fixed-ratio schedules of food presentation and stimulus-shock termination. | Effects of d-amphetamine and ethanol were assessed on comparable behaviors maintained under fixed-ratio schedules of either food presentation or termination of electric shock and an accompanying visual stimulus. Ethanol affected the behaviors similarly in all important aspects; d-amphetamine increased rates of respondi... | 415,314 | [
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Cholinergic inhibition of methylphenidate-induced stereotypy: oxotremorine. | Lethality of orally administered oxotremorine for female mice required 250 times the dose that was effective for inhibiting methylphenidate-induced stereotypy. A number of lines of evidence indicate that increasing central cholinergic activity may be useful in various psychiatric syndromes and movement disorders. A rel... | 415,317 | [
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Idiotypy of measles virus nucleocapsid-specific IgGkappa antibody in serum and cerebrospinal fluid in subacute sclerosing panencephalitis. | A gel-precipitating anti-idiotypic antiserum was prepared in a rabbit by immunization with measles virus-specific IgG isolated from the serum of a patient with subacute sclerosing pancencephalitis (SSPE). The idiotypic determinant was associated with an electrophoretically restricted and cathodally migrating IgGkappa p... | 415,354 | [
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Foreign aid support of science and economic growth. | The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort. | 415,363 | [
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Muscle crossbridge stroke and activity revealed by optical diffraction. | Optical diffraction measurements during rapid releases of active toad muscle show that the sarcomeres contract within 1 millisecond by an amount up to but not greater than 12 nanometers. This crossbridges immediately start cycling to produce the normal contraction velocity in unloaded muscle. | 415,364 | [
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[A microcalorimeter for assessment of the G-value of a ferrous sulfate solution for high-energy electrons (author's transl)]. | A microcalorimeter with constant ambient temperature has been designed (circa -195 degrees C = temperature of the absorber), which could be utilized with doses from 10 rd upward. The G-value for ferrous sulfate was assessed by means of comparison measurements with the calorimeter and a Fricke-dosimeter, using two diff... | 415,384 | [
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Lysosomal non-lipid component of Gaucher's cells. | An ultrastructural, histochemical and chemical analysis of storage elements in the infantile form of Gaucher's disease showed that in addition to cerebroside the lysosomes also included a non-lipid component of protein, or possibly glycoprotein nature. This component, easily removable with trypsin, was present in such ... | 415,425 | [
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[Hypophosphatemia during parenteral nutrition of patients with renal insufficiency (author's transl)]. | Hypophosphatemia is a much commoner condition than generally recognized from investigations on this subject so far. Hypophosphatemia may cause ill-defined disturbances in the course of illness in patients with renal insufficiency. On the basis of our results we recommend the addition of 5--10 mmol phosphate (155--310 m... | 415,439 | [
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Thrombocytopenia and iron deficiency anaemia in a patient with alpha1-thalassaemia trait. Response to iron therapy. Case report. | Iron deficiency anaemia secondary to menorrhagia was observed in a woman of Greek Cypriot origin. Moderate thrombocytopenia was also present. Treatment with parenteral and oral iron produced a transient thrombocytosis, the platelet count then returning to normal. Subsequent analysis revealed that she also carried the a... | 415,476 | [
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A simple method for demonstrating gel-precipitating human anti-immunoglobulin antibodies. | The use of aggregated human IgG for the detection of anti-immunoglobulin antibodies by double immunodiffusion in gel is described. Of rheumatoid arthritis sera, 54 of 56 sera having a Waaler-Rose test titre of greater than or equal to 1:16 contained antibodies to aggregated IgG, in contrast to only 2 of 52 sera from bl... | 415,514 | [
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An "on-line" colorimetric method for repeated, rapid determinations of capillary diffusion capacity. | The single injection indicator diffusion method for estimation of capillary diffusion capacity (Crone 1963) has been developed to provide directly visualized, continuous colorimetric recordings of the venous time-concentration curves by means of a two-colour densitometer system. Cardio-Green, bound to albumin, is used ... | 415,516 | [
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Effect in vitro of ioglycamide on blood proteins and paraproteins. | No modification of plasma or serum viscosity was observed after in vitro addition of ioglycamide in a series of 160 healthy subjects and 1 467 patients including 33 cases of IgM paraproteinemia, 20 with Waldenström's disease. The labelled contrast medium never bound to paraproteins. These results are contradictory to t... | 415,519 | [
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Goniodysgenesis in exfoliation glaucoma. | According to our material the exfoliation glaucoma can be regarded as the result of an interplay of at least two different pathologic conditions: a primary genetic goniodysgenesis creating a relative block to the outflow, and a probable vasculopathy in the iris. Subsequent degeneration of the iris will lead to a libera... | 415,529 | [
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Aspirin and ulcers. | In eastern Australia, there is an epidemic of gastric ulcer which began 30 years in young women who are now middle-aged, (b) This epidemic is associated with the regular use of aspirin most often in the form of A.P.C. powders taken for non-medical reasons, (c) Data from three separate studies in America confirms a stat... | 415,531 | [
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Respiratory distress syndrome: progress in prenatal prediction and prevention. | The concept of idiopathic respiratory distress syndrome (RDS) as a disease of multiple etiology has shifted during the past decade to that of a developmental biochemical dysfunctional state which has a distinct pattern of clinical expression. Knowledge of the biosynthetic processes of physiologic lung maturation togeth... | 415,541 | [
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New technique for localization of therapeutic emboli using radionuclide labeling. | A sensitive method for localizing the resting place of catheter-injected therapeutic gelatin emboli is described. Surgical gelatin (Gelfoam) is labeled with 99mTc and each embolus observed on the persistence scope of a gamma camera after injection. This technique reduces the chance of obstructing blood vessels other th... | 415,562 | [
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The inferior vena cava: mass effects. | Gray scale ultrasound evaluation of the inferior vena cava is essential for adequate workup of abdominal tumors. Demonstration of perivascular nodal masses and/or invasion of the inferior vena cava is of prognostic significance and of value in planning the surgical approach. In addition, accurate delineation of the ext... | 415,564 | [
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Hypophysial portal vascular infusion of TRH in the rat: an ultrasturctural and radioimmunoassay study. | The hypophysial portal vessels and anterior pituitary gland of adult male Wistar rats were exposed surgically. A hypophysial portal vessel was cannulated and infused for one minute with saline or thyrotrophin (TRH). Anterior pituitary glands were collected at 1,5,15,30 or 60 minutes after cessation of infusion, for lig... | 415,588 | [
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Intravenous feeding of the rat with short chain fatty acid esters. II. Monoacetoacetin. | Acetoacetic acid is oxidized independent of carnitine transport into the cell mitochondria and its monoglyceride is a water soluble compound. The latter was examined as an intravenous nutrient. The monoglyceride of acetoacetic acid was prepared from the acid anhydride, diketene, and glycerol and was found to be totally... | 415,593 | [
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Control of fraud and abuse in Medicare and Medicaid. | This Comment explores issues concerning the control of fraud and abuse in health programs financed with public funds, specifically the Medicare and Medicaid programs. It summarizes the nature, scope, and possible causes of what some regard as a fraud and abuse "crisis," and points out the difficulties and obstacles fac... | 415,602 | [
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Visual evoked responses in strabismic and anisometropic amblyopia: effects of check size and retinal locus. | Sinusoidally modulated checker board patterns were used to investigate the effects of check size and retinal location on the "steady-state" visual evoked response (VER) of strabismic and anisometropic amblyopes. Fourier analysis of the averaged VER suggests that the waveforms produced by these techniques are complex, a... | 415,614 | [
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Morphologic effects of dietary plant and animal lipids rich in docosenoic acids on heart and skeletal muscle of cynomolgus monkeys. | Cynomolgi (Macaca fascicularis) were fed diets containing 25% rapeseed oil (RSO), partially hydrogenated herring oil (PHHO), or a 3:1 mixture of lard and corn oil as control for 4 months. The RSO contained approximately 25% of the fatty acids as erucic acid; the PHHO contained a similar concentration of mainly cetoleic... | 415,615 | [
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15alpha-Hydroxyoestriol and other polar oestrogens in pregnancy monitoring. | Although oestriol measurements are well established for the assessment of 'at risk' pregnancies, there are a number of other oestrogens, excreted during pregnancy, which contain additional hydroxyl groups and might be more sensitive indicators of the condition of mother or fetus. Some of these result from the action of... | 415,657 | [
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[Biological properties of an asparaginase-glutaminase preparation from Pseudomonas fluorescens in cell cultures]. | Specific L-asparaginase activity and non-specific cytotoxicity of asparaginase-glutaminase preparation from Pseudomonas fluorescens were studied. Two cell lines, i.e. the asparaginase-dependent (Berkitt lymphoma cells) and the asparaginase-independent (the ovary cancer cells) were used as the test-system. Incorporation... | 415,658 | [
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[Long-term results of aortocoronary bypass. 1. Clinical aspects]. | Eighty patients undergoing one or several aorto-coronary bypass graft procedures had longterm clinical and arteriographic follow-up (mean follow-up period of two years, extremes 1 and 6 years). The indication fort operation in these patients was unstable angina in 39 (49%), threatened infarction in 16 (20%), Prinzmetal... | 415,676 | [
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[Action of chloro-acetyl-ajmaline on the electrical properties of the human heart]. | The electrophysiological changes caused by the intra-atrial injection of 1.5 mg/kg of chloro-acetyl-ajmaline were studied in 23 patients by recording the His potential and by the stimulustest method. The length of the basal cycle being kept constant by atrial stimulation, measurements were made before and after the inj... | 415,694 | [
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[The significance of in-vitro tests with respect to testing of substances for carcinogenic activities (author's transl)]. | The actual possibilities to test chemical substances for carcinogenic activities are critically assessed. Short-term-tests are especially discussed. By these tests--now utilized for screening of chemicals--specific biological activities can be determined, which correlate with carcinogenic effects in vivo. The phase of ... | 415,699 | [
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Arteriovenous fistulas for long-term dialysis. Factors that influence fistula survival. | We reviewed our total experience with arteriovenous (AV) fistulas for long-term hemodialysis. We are unable to show any significant difference in the survival of AV fistulas based either on the type of material used to create the fistulas or on their location. Complications encountered early in this experience largely ... | 415,701 | [
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Biological characteristics of a stimulatory factor for viral replication detected in egg fluids. | Yolk sac and allantoic fluids and albumen from uninfected chicken eggs contain a low-molecular weight factor which, after 90 minutes of contact with cell cultures, significantly enhances viral replication. Of several viruses tested, Semliki Forest virus exhibited the highest (10(5)-fold) responsiveness to this enhancin... | 415,702 | [
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Prognostic factors in the survival of 1,484 stroke cases observed for 30 to 48 months. I. Diagnostic types and descriptive variables. | Survival and factors affecting survival were studied in 1,484 new cases of acute definite stroke occurring between Jan 1, 1970, and June 30, 1971, in Manitoba. The 962 infarctions, 279 hemorrhages, and 243 unidentified strokes were ascertained from hospital claim reports. Personal, clinical, and laboratory data were co... | 415,705 | [
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A passive hemagglutination test for detecting bovine serum albumin antibodies. | A microtiter passive hemagglutination test is described for detecting and titrating antibodies in chickens. Chicken erythrocytes are coated with antigen (bovine serum albumin = BSA) in the presence of 0.25% glutaraldehyde. Such sensitized erythrocytes are agglutinated in the presence of antibodies against BSA. The sens... | 415,728 | [
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Connective tissue composition of aortas from non-human primates. A comparative study. | Connective tissue composition of aortas from several non-human primate species has been studied in an effort to relate collagen, elastin, ang glycosaminoglycan (GAG) content to species susceptibility to atherosclerosis. Among the species studied the baboon contained the highest content of GAG in the aorta. While the di... | 415,748 | [
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Studies of HLA antigens in multiple sclerosis. | This review describes the presently available data on HLA typing in patients with multiple sclerosis (MS). Almost 2,000 MS patients and 12,000 normal controls have been studied with HLA typing in 15 different laboratories. The combined data show remarkably homogeneous results, and are as summarized: an increased freque... | 415,750 | [
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Effect of age, weight and adequacy of zinc intake on the balance between alkaline ribonuclease and ribonuclease inhibitor in various tissues of the rat. | 1. Deficiency of zinc inhibits growth and also increases the activity of alkaline ribonuclease in certain tissues of the rat (Prasad & Oberleas, 1973). Zn could influence ribonuclease activity by direct effects on the enzyme or its natural inhibitor, or non-specifically as occurs when growth rate is affected by var... | 415,757 | [
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Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes. | A simple, rapid radiochemical assay for prostacyclin synthesis has been used to characterize the enzyme in arterial walls which converts prostaglandin endoperoxides to prostacyclin. The enzyme displays a broad pH optimum, and catalyses a rapid conversion of saturating concentrations of the endoperoxide at 37 degrees C.... | 415,760 | [
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Apparent absence of symmetrical transcription in Tetrahymena mitochondria. | Transcription in Tetrahymena pyriformis mitochondria has been examined for whether or not symmetrical transcription occurs. A ribonuclease A digestion in high-ionic strength was used as a test for the presence of double-stranded RNA (dsRNA) either before or after self-annealing. This test was applied to RNA prepared us... | 415,806 | [
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Etiology of the negative chronotropic responses to transient coronary artery occlusion in the anesthetized rhesus monkey. | Etiology of the negative chronotropic response to coronary artery occlusion was studied in chloralose-anesthetized monkeys. One-minute occlusion of the circumflex (CIRC) coronary artery resulted in marked negative chronotropic responses and consistent alterations in atrial electrograms. These responses were dependent o... | 415,826 | [
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Pulmonary and endocrine function before and after therapy with cromolyn sodium in asthma. Studies in steroid-dependent and nonsteroid-dependent asthmatic children and adolescents. | This study evaluated growth, chest radiographic manifestations, pulmonary function, and function of the pituitary-adrenal axis before and after therapy with cromolyn sodium in two groups of asthmatic youngsters, ie, 18 steroid-dependent patients and ten nonsteroid-dependent patients. The following three groups evolved:... | 415,844 | [
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Phosphorylation in vivo of Ribosomes in Tetrahymena pyriformis. | Phosphorylation of ribosomal proteins in vivo was studied in exponentially growing and starved cells of the ciliated protozoan, Tetrahymena pyriformis. No phosphorylation of ribosomal proteins could be demonstrated in cells growing exponentially in complex nutrient media. However, when Tetrahymena cells were transferre... | 415,860 | [
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The chemistry of the reaction of 2-hydroxy-5-nitrobenzyl bromide with his-32 of alpha-lactalbumin. | His-32 of bovine or human alpha-lactalbumin reacts with the tryptophan reagent 2-hydroxy-5-nitrobenzyl bromide at pH 7. The reaction depends on the native conformation of the alpha-lactalbumin molecule and it is restricted to position 1 of the imidazole nucleus. The synthesis and characterization of 1-(2-hydroxy-5-nitr... | 415,861 | [
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Absent kidney sign associated with symmetrical and uniformly increased uptake of radiopharmaceutical by the skeleton. | In 11 patients 99mTc-stannous H.E.D.P. bone scans showed absent renal images associated with symmetrical and uniformly increased uptake of radiopharmaceutical by the skeleton. These appearances are frequently seen in renal osteodystrophy but are uncommon in malignant disease. Their significance in hypervitaminosis D re... | 415,864 | [
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Intensity coding in primate visual system. | The pupil reflex and the discharge of LGN cells of the awake macaque were measured under stimulus conditions that yielded evidence for wide-range intensity coding in human psychophysical experiments. Ganzfeld flashes of white light were delivered under dark-adapted conditions to the surgically immobilized eye of the mo... | 415,894 | [
0.1893754,
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0.08715052,
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0.3689742,
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... |
Evaluation of a surgical method for immobilizing the eye of an alert monkey. | One eye of a macaque monkey was immobilized by severing the third, fourth, and sixth cranial nerves. The residual movements of the operated eye were measured by repeatedly mapping the position of a visual receptive field. Movements of several degrees were caused by contraction of the orbital musculature during the clos... | 415,895 | [
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The incomplete anti-Rh antibody agglutination mechanism of trypsinized ORh+ red cells. | The capacity for binding to trypsinized and non-trypsinized ORh+ red cells, of the IgG incomplete anti-Rh antibody and its F(ab')2 and Fc fragments has been investigated. An analysis has also been made of the capacity of non-specific human IgG, aggregated non-specific human IgG, human IgM (19S) and IgM (7S), and of fra... | 415,968 | [
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[Nitrogen balance and plasma amino acids in premature and newborn infants with partial parenteral feeding during the first 3 days of life]. | Eight pre-terms, five with postnatal asphyxia, two hypotrophic newborns and one term infant with severe postnatal asphyxia (mean birth weight 2317 g) were fed in addition to oral nutrition partialy parenterally with glucose solution and a mother-milk adapted amino-acid solution during their first three days of life. At... | 415,975 | [
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0.0739414... |
Impaired chemotactic responsiveness of macrophages from gnotobiotic rats. | Peptone-induced macrophages obtained from gnotobiotic (GB) rats responded poorly to chemotactic stimuli that have a powerful, attractive influence upon the cells of conventional donors. Monocyte recruitment from the circulation into peptone-induced exudates also was impaired in GB subjects. Although relatively more res... | 415,979 | [
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Biochemical studies on polychlorinated biphenyl toxicity in rats: manipulation by vitamin C. | The effects of chronic polychlorinated biphenyl (PCB) compound toxicity on L-ascorbic acid metabolism in rats have been studied. PCB treatment brought about a depression in the activities of the enzymes L-gluonolactone oxidase and dehydroascorbatase along with an increased tissue levels and urinary excretion of L-ascor... | 415,995 | [
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0.0816... |
Anti-glycosyl antibodies. Two sets of isoantibodies with specificity for different carbohydrate moieties of the same glycosyl antigen. | Two sets of anti-glycosyl antibodies have been isolated by affinity chromatography methods from the antisera of rabbits immunized with a vaccine of nonviable cells of Streptococcus faecalis, strain N. Both types of antibodies are directed against a dineteroglycan of glucose and galactose present in the cell wall of thi... | 416,019 | [
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... |
Modified culture technique for Corynebacterium diphtheriae isolation from desiccated swabs. | Corynebacterium diphtheriae was isolated from pyoderma and ulcerative skin lesions with a modified delayed culture procedure as late as 9 weeks after field collection of silica gel-desiccated swabs. Biotypes gravis and mitis were identified. Most isolates were nontoxigenic. Todd-Hewitt broth enrichment enhanced recover... | 416,036 | [
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... |
Regulation of thyrotrophin secretion by negative feedback of tri-iodothyronine on the hypothalamus. | Bilateral injections of tri-iodothyronine (T3, 2 ng in 2 microliter artificial cerebrospinal fluid, CSF) were made into the hypothalami of 15 hypothyroid rhesus monkeys (Macaca mulatta) prepared with chronically implanted intrahypothalamic cannulae. In 29 out of 96 such injections, the concentration of thyrotrophin (TS... | 416,161 | [
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0.0009177211,
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0.... |
Protection against group B meningococcal disease. II. Infection and resulting immunity in a guinea pig model. | A guinea pig subcutaneous chamber model was used to evaluate the specificity of the immune response resulting from Neisseria meningitidis infection. Small numbers of meningococci easily infected the chambers. The infections persisted for 6-8 days with relatively high levels of organisms (10(5)-10(6)/milliliter) in the ... | 416,163 | [
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0.1372678,
-... |
Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. | Spleen cell cultures from young adult mice of a variety of strains were stimulated to incorporate tritiated thymidine ([3H]TdR) by a goat anti-mouse IgM antiserum and by purified anti-mu antibodies prepared from this serum. This stimulation was shown to depend upon the anti-mu activity of the antiserum. In addition, ul... | 416,168 | [
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... |
Electron microscopy and computerized evaluation of some partially denatured group P resistance plasmids. | DNA of the R plasmids RP1, RP4 and RP8 was isolated from various hosts. The lengths of these plasmid molecules were determined by electron microscopy: RP1 and RP4 were about 19 micron long, RP8 measured 31 micron. An RP4 plasmid mutant, designated RP4a, was isolated from Escherichai coli; it was about 1 micron shorter ... | 416,173 | [
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Internal calcium concentration and potassium permeability in Paramecium. | Ca or EGTA was ionophoretically injected into Paramecium tetraurelia to change [Ca]i. Ca decreased the resting membrane resistance and hyperpolarized the membrane. EGTA had the opposite effect. EGTA following TEA, which suppress GK, had little effect on resistance or resting potential. The I-V relation at steady state ... | 416,178 | [
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Zinc deficiency during total parenteral nutrition in childhood. | Changes in plasma zinc levels were studied in 11 pediatric surgical patients treated with total parenteral nutrition. Plasma copper levels were also determined in some patients. In three patients plasma zinc fell to a very low level during long-term total parenteral nutrition, and a syndrome of zinc deficiency develope... | 416,197 | [
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0.5396887,
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Leucocytozoonosis in Canada geese in upper Michigan,. 1. Strain differences among geese from different localities. | Geographic variation in pathogenicity of Leucocytozoon simondi in Canada geese (Branta canadensis maxima) was investigated by exposing goslings to natural infection at three locations in the upper peninsula of Michigan. Examination of blood smears and tissue sections revealed two patterns of development. Hepatic schizo... | 416,231 | [
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[Dosage effects of the non permissive allele of Drosophila ref(2)P gene on sensitive strains of sigma virus (author's transl)]. | Different characteristics of flies relating to sigma virus allow us to class the following drosophila genotypes according to their permissivity for the virus strains which are sensitive to the Pp allele: (formula: see text). It is concluded 1) that the two alleles Po and Pp of ref(2)P gene are active and 2) that the vi... | 416,337 | [
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... |
Address of the President. Look around with awareness. | In conspectus, consideration is given to the first "academy" in ancient Greece, current national health goals, change affecting health and medical care in the United States, and evolution--as well as the promising future--of the American Academy of Ophthalomology and Otolaryngology. Contemplating the future, the advice... | 416,407 | [
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[Total parenteral nutrition in the adult. Theoretical aspects (author's transl)]. | When oral or enteral feeding becomes impossible or inadequate, total parenteral nutrition makes it possible to reduce the occurrence of malnutrition states as complications of medicosurgical disorders. From a practical point of view it should provide a minimum fluid intake of 30 ml/kg with a nitrogen intake of the orde... | 416,420 | [
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0.176699,
... |
Inhibition of prostaglandin biosynthesis by c-5,c-8,c-11-eicosatrienoic acid. | The enzyme prostaglandin H leads to E-isomerase (EC 5.3.99.3), which is present in sheep vesicular gland and needs glutathione as cofactor, is inhibited by c-5,c-8,c-11-eicosatrienoic acid, the fatty acid accumulating during essential fatty acid deficiency. The EFA-deficiency syndrome can partly be explained from a pro... | 416,467 | [
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0.20... |
The extent and causes of malnutrition in children in the Tsolo district of Transkei. | A survey of children under 5 years old living in a rural Transkei village was carried out. It was found that 36% of the children were below the Boston third percentile (BTP) (including 57% of those children between the ages of 18 and 32 months), and that nearly 30% die before the age of 2 years. The relative importance... | 416,500 | [
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0.7061392,
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Specific double diffusion microtechnique for the diagnosis of aspergillosis and paracoccidioidomycosis using monospecific antisera. | Using experimental reference sera against species-specific antigens of Aspergillus fumigatus and Paracoccidioides brasiliensis in a microdouble diffusion technique, a simple and specific test for the immunodiagnosis of aspergillosis and paracoccidioidomycosis has been developed. Only sera that produced lines of identit... | 416,505 | [
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-0.0509147... |
Attempts to induce immunological enhancement for kidney allografts in rhesus monkeys. | Various rhesus alloantisera were tested for their capacity to induce enhancement of kidney allograft survival in D locus-incompatible rhesus monkeys. Six experimental groups were investigated: 1, ten allografted monkeys remained untreated; 2, six recipients were treated with Imuran and prednisolone; 3, eight rhesus mon... | 416,527 | [
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0.0641183,
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-0.0... |
Scanning and transmission electronmicroscopy of leukemic lymphoma cells without T- and B-cell surface markers. | The lymphoma cells from a patient with leukemia lymphoblastic sarcoma (Kiel classification) were observed by scanning and transmission electron microscopy. These cells were also examined by E, EA, EAC rosette-formation tests and by the indirect immunofluorescence technique for surface immunoglobulins. The malignant cel... | 416,585 | [
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0.01861471,
0.0214154... |
Lactoferrin in human neutrophilic polymorphonuclear leukocytes in relation to iron metabolism. | Lactoferrin (LF), the iron-binding protein of external secretions and neutrophilic polymorphonuclear leukocytes (PMN), was studied in 27 patients during granulocytosis caused by acute inflammation and in disorders without granulocytosis (iron deficiency anemia, iron overload and liver diseases). During granulocytosis t... | 416,654 | [
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0.04343015,
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0.2110982,
-0.274481... |
Sero-epidemiology of herpes type-2 virus and carcinoma of the cervix in Ibadan. | Various sero-epidemiologic studies, including the preliminary report from Ibadan, have established that most women with premalignant and malignant carcinoma of the cervix have serologic evidence of infection of herpes type-2 virus. Using immunofluorescence method, the earlier report in Ibadan was confirmed, whereby the... | 416,672 | [
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Angiography of abdominal leiomyosarcoma. | The spectrum of angiographic findings of abdominal leiomyosarcoma in 33 cases is presented, and the value of angiography in the diagnosis and management of such patients is discussed. Angiographic features of abdominal leiomyosarcomas are different depending upon the site of origin. Small bowel lesions are hypervascula... | 416,684 | [
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Gray scale ultrasonography of adrenal neoplasms. | Ultrasonic characteristics of 21 adrenal neoplasms (19 patients) examined by gray scale ultrasonography are reviewed. The significance of the adrenal-renal cleavage plane is discussed. In our experience the cleavage plane only has definite localization value when it separates the adrenal gland from the kidney on all ul... | 416,687 | [
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Diagnosis of ascending transtentorial herniation by cranial computed tomography. | The secondary effects of large infratentorial masses may include ascending transtentorial herniation. Rostral displacement of the superior vermis through the tentorial incisura can be accurately detected by cranial computed tomography. Signs of early or impending upward herniation are compression and slight posterior f... | 416,691 | [
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-0.2374894,
0.01760324,
-0.3799844,
-0.245296,
0.02808836,
0.1638382,
0.04981468,
0.... |
The trisomy 4p syndrome: case report and review. | We report a further case of trisomy 4p: a 5-year-old mentally retarded boy with characteristic facial features, eye abnormalities, flexion contractures, several bone anomalies, and hyperactivity. In a review of 27 cases (11 male, 16 female, 22 families) the cytogenetic and clinical data were tabulated and analyzed. Dia... | 416,713 | [
-0.3354376,
0.009089133,
0.04155435,
-0.3422453,
0.02830716,
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-0.1040855,
0.02266196,
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0.03640694,
0.1541073,
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0.1458198,
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0.3305455,
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-0.01140897,
0.3034443,
-0.00007748272,
0.0270... |
Morquio-like syndrome with beta galactosidase deficiency and normal hexosamine sulfatase activity: mucopolysacchariodosis IVB. | A 14-year-old white girl with mild dysostosis multiplex, odontoid hypoplasia, short stature, cloudy corneas, keratansulfaturia, but without detectable central nervous system abnormalities was referred with the diagnosis of Morquio syndrome. Clinical and roentgenographic findings were minimal compared to those of typica... | 416,714 | [
0.07678226,
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-0.08504618,
-0.01877678,
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0.1716501,
0.290343,
-0.1242469,
0.5161863,
0.189382,
0.03877332,
... |
Production of penicillic acid and patulin by an atypical Penicillium roqueforti isolate. | Simultaneous production of penicillic acid and patulin by an atypical strain of Penicillium roqueforti isolated from cheddar cheese is reported. Mycotoxin production was confirmed by thin-layer and gas-liquid chromatography and by ultraviolet, infrared, and mass spectral analyses. Culture extracts were toxic to Bacillu... | 416,750 | [
-0.2708676,
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0.02830129,
0.2157501,
0.5071757,
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0.1589094,
0.342365,
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0.2251813,
0.1189771,
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0.5554081,
0.6590573,
0.192916,
0.1028844,
... |
[Pseudoaneuysms of the heart after myocardial infarct. Apropos of 5 operated cases]. | The authors base themselves on 5 personal cases and a review of the literature to summarise the clinical and paraclinical features of false aneurysms of the heart. The clinical features differ from those of true aneurysms only slightly. It is only arteriography, which shows up the collar and the slow evacuation of the ... | 416,768 | [
-0.2946227,
0.02432132,
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0.06447749,
0.004978686,
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-0.1046779,
0.0663976,
-0.1188226,
0.2273344,
0.5614055,
0.08266741,
-0.126... |
[Resections of the left ventricle in the surgical treatment of parietal sequelae of myocardial infarct]. | Resection of left ventricular tissue seems to be playing an increasing part in the treatment of the sequelae of myocardial infarction. In a total of 700 patients who underwent surgery for some aspect of coronary atherosclerosis, 40 underwent resection of left ventricular tissue. In the majority of cases, diagnosis rest... | 416,785 | [
-0.0819637,
0.06840032,
-0.1300836,
-0.1410652,
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-0.4016193,
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0.1200265,
0.03392732,
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0.1371118,
-0.1067535,
-0.1038261,
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-0.3331518,
0.004002495,
0.04099929,
0.4059948,
0.412909,
0.27046,
-0.1379987,
0.... |
[Treatment of acute arterial occulusions with streptokinase]. | Of the patients treated within the first week after thrombo-embolic occulusion of the arteries of the lower limb 45% achieve total disobliteration with thrombolytic therapy. The authors discuss the factors influencing disobliteration, as well as the mortality and complications of thrombolytic treatment using streptokin... | 416,788 | [
-0.1188504,
-0.01519823,
-0.2630824,
0.3312175,
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0.05028446,
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-0.1303363,
-0.1930171,
0.08829748,
-0.3813577,
-0.308061,
-0.1037821,
-0.1970664,
0.2017664,
0.5129979,
0.3158323,
-0.321886... |
A chromosome substitution analysis of geotactic maze behavior in Drosophila melanogaster. | Positive and negative geotactic maze behaviors were selected in strains of Drosophila melanogaster, for over 40 generations on 15-unit classification mazes. A chromosome substition analysis of these behaviors was undertaken to determine which of the three major chromosomes is most important in causing the differences i... | 416,821 | [
0.2222079,
0.2007846,
0.08549381,
-0.03303187,
0.04095582,
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0.02275912,
-0.1497814,
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0.5408629,
-0.2594395,
0.195114,
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0.1346909,
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0.1304996,
-0.2788126,
-0.1848177,
0.21465,
0.3092285,
0.2532744,
-0.... |
A cytochrome b-like pigment with a peak at 567 nm in Pseudomonas aeruginosa. | A cytochrome b - like pigment with an absorption peak at 567 nm was detected in Pseudomonas aeruginosa irrespective of whether the organism was grown aerobically or anaerobically under denitrifying conditions. This pigment has not been reported previously for P. aeruginosa but it has been detected in other denitrifying... | 416,897 | [
-0.3068287,
-0.2258,
-0.3746739,
0.06334277,
-0.3290344,
0.1076915,
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0.1480617,
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0.1045902,
0.1752664,
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0.01158625,
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-0.4680032,
0.1905876,
0.3535988,
-0.2190056,
0.243815,
0.2506738,
0.05927243,
0.029... |
Circulating thyroid hormone levels and adequacy of dialysis. | In vitro thyroid function tests were performed in three groups of patients with chronic renal failure who were receiving, on average, 15, 18 and 27 hours of maintenance hemodialysis per week. Total thyroxine levels were low and total triiodothyronine levels low to normal in those receiving the least dialysis (15 hours)... | 416,931 | [
-0.1816703,
-0.04526856,
-0.2398749,
-0.0907346,
0.1904604,
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-0.08217167,
0.25059,
-0.1994807,
0.07009396,
0.18466,
0.3228438,
-0.1030684,
0.2997278,
-0.07809147,
-0.1229893,
-0.115722,
0.1267564,
-0.1520408,
-0.1190929,
-0.01831692,
0.3893021,
-0.1123518,
-0... |
Isolation and characterization of free cytoplasmic messenger ribonucleoproteins from rabbit reticulocyte. | Free cytoplasmic messenger ribonucleoproteins have been prepared with a high yield in a zonal rotor. They are rapidly labelled by [3H]uridine. Their sedimentation coefficients are 14.6 S and 19.4 S. Their protein contents are higher than in ribosomes, as indicated by a shift towards greater wavelength in their ultravio... | 416,957 | [
0.2180479,
0.2244226,
0.09470052,
0.04268396,
-0.05511861,
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0.1995335,
0.1667403,
0.2931803,
0.08029097,
0.08789944,
0.167577,
0.2064149,
-0.226057,
0.1073816,
-0.3960786,
-0.04806247,
0.0005749117,
0.006995825,
0.5169395,
-0.03519085,
-0.2208607,
... |
The binding site of ribosomal protein L1 from Escherichia coli on the 23-S ribosomal RNA from Bacillus stearothermophilus. A possible base-pairing scheme differing from that proposed for Escherichia coli. | The region of Bacillus stearothermophilus strain NCA 1503 23-S ribosomal RNA protected from T1 ribonuclease digestion by the 50-S ribosomal subunit protein L1 from Escherichia coli has been established. The sequence of 115 nucleotides is compared to the analogous region in E. coli. The similar behaviour of the RNA towa... | 416,958 | [
0.003675164,
0.2639725,
0.009819797,
-0.1682702,
-0.1588211,
-0.08435543,
-0.3589305,
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0.2939683,
0.08225343,
0.2238228,
0.1449745,
-0.04701028,
-0.3710526,
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0.02856134,
-0.07688794,
-0.1802907,
-0.1616934,
0.5322729,
0.3104756,
-0.3714... |
Pituitary-adrenal response to separation in mother and infant squirrel monkeys. | Pituitary-adrenal response in mother and infant squirrel monkeys following brief separation was assessed. Each mother and infant pair was tested under each of 3 conditions: (1) Basal; (2) Separation-Reunion; and (3) Separation. Samples were obtained from mothers and infants in the Separation and Separation-Reunion cond... | 416,983 | [
0.2185295,
0.05729757,
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-0.4408653,
-0.079333,
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-0.06321105,
0.1159516,
0.147737,
-0.04425486,
-0.3771101,
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-0.4805082,
0.1436963,
0.09978696,
0.1926753,
0.1178956,
0.05201467,
0.04059735,
-... |
[A contribution to the problem of heterologous insemination (author's transl)]. | The problem of a heterologous insemination must occasionally be dealt with. The conditions for such treatment are not good in the Federal Republic of Germany. This, however, should not negatively influence the quality of the therapy. At least the serologic characteristics of the donor should be known. The impetus for t... | 416,991 | [
0.006890932,
0.03340598,
-0.06671815,
0.09742924,
0.2874639,
-0.4053164,
-0.3158516,
0.1107649,
0.1760368,
0.07571553,
0.3646651,
0.04646357,
0.1100307,
0.01813553,
-0.3949475,
-0.3033589,
-0.3318735,
-0.07403337,
-0.295967,
0.02457106,
0.3438806,
0.05471778,
-0.02391258,... |
Free light chain synthesis by neoplastic cells in chronic lymphocytic leukaemia and non-Hodgkin's lymphoma. | Cell populations from twenty-two cases of B-cell neoplasia reflecting various stages of B-lymphocyte maturation were investigated for their ability to synthesise immunoglobulin (Ig) in vitro. All surface Ig positive neoplasms studied synthesised labelled Ig of the same light chain class as that expressed at the cell su... | 417,018 | [
-0.2870139,
-0.1705158,
-0.385397,
-0.1860116,
0.2719654,
-0.180745,
0.0003623287,
0.155306,
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0.4858036,
0.0602571,
0.2380216,
0.01388398,
0.28698,
0.05655666,
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-0.1856522,
0.07007175,
-0.1149742,
0.2101033,
0.5276289,
0.005806213,
-0.1853708,
0.204... |
Detection of antibodies to Neisseria gonorrhoeae by counterimmunoelectrophoresis. | Antigen was partially purified from Neisseria gonorrhoeae B370 saline wash and used to assay human sera for the presence of antibodies to N. gonorrhoeae. The antigen activity as monitored by counterimmunoelectrophoresis (CIE) is resistant to trypsin and papain but sensitive to heat and periodate oxidation. Of the sera ... | 417,047 | [
-0.005967888,
-0.0977758,
-0.3146068,
0.05211688,
-0.09768135,
0.06305227,
-0.2019987,
-0.1357601,
0.007258264,
0.04119673,
0.3097022,
0.1903285,
-0.01227994,
-0.2435422,
0.05005948,
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-0.5025912,
0.03004734,
-0.1744488,
-0.1292123,
-0.05069107,
0.01199736,
-0.0... |
The selectivity of vancomycin and lincomycin in NYC medium for the recovery of N. gonorrhoeae from clinical specimens. | Varying concentrations of vancomycin and lincomycin were tested separately in NYC medium to determine the degree of their selectivity and sensitivity for isolation of N. gonorrhoeae from clinical specimens. Results indicate that 2 microgram/ml of vancomycin used in conjunction with colymycin, amphotericin B, and trimet... | 417,048 | [
0.1623263,
-0.2484742,
-0.460227,
0.04865607,
0.06538863,
0.07490717,
-0.2767054,
-0.02420678,
-0.04090915,
-0.2316199,
-0.1259827,
0.1675699,
0.08978102,
0.4239926,
0.08095535,
-0.6057014,
-0.6330717,
0.0544524,
-0.2327978,
0.1989175,
0.2004783,
-0.01358062,
0.1149253,
... |
Binding and transport of thiamine by Lactobacillus casei. | The relationship between thiamine transport and a membrane-associated thiamine-binding activity has been investigated in Lactobacillus casei. Thiamine transport proceeds via a system whose general properties are typical of active uptake processes; entry of the vitamin into the cells requires energy, is temperature depe... | 417,062 | [
-0.2789363,
-0.2478132,
-0.03388605,
-0.03024178,
0.2555923,
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0.2908607,
0.04764992,
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0.1708772,
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-0.1344563,
0.09436107,
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-0.7479655,
-0.0143913,
-0.4506384,
0.1651297,
0.4461336,
0.3316791,
-0.207428,
... |
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