title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Ontogeny and distribution of immunoreactive gastric inhibitory polypeptide (IR-GIP) in rat small intestine. | The ontogeny and distribution of immunoreactive gastric inhibitory polypeptide (IR-GIP) has been studied in the rat duodenum and jejunoileum between day 20 post-coitum and day 150 post-partum by radioimmunoassay following tissue extraction. In foetuses on day 20 of gestation, the content of IR-GIP was 2.0 +/- 0.2 ng/du... | 419,918 | [
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Primary rhabdomyosarcoma of the cerebrum. An ultrastructural study. | A case of primary cerebral rhabdomyosarcoma in a 51-year-old female is reported. The histogenesis of this tumor is discussed. The clinicopathological features of 10 previously reported similar tumors of the CNS are briefly reviewed. Histologically the tumor was polymorphic, but composed of poorly differentiated cells i... | 419,933 | [
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Red cell 2.3-diphosphoglycerate in pregnancy. | In normal, primigravidae red cell 2.3-diphosphoglycerate (2.3-DPG) concentration was found to be increased significantly from the third month of pregnancy. The 2.3-DPG concentration remained elevated throughout pregnancy. Increase in the 2.3-DPG concentration leads to a decrease in the oxygen affinity of the maternal r... | 419,949 | [
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The aetiology and outcome of abruptio placentae. | A series of 193 cases of abruptio placentae in a hospital population of 35,217 is described. This is an incidence of 0.55%. In the series both age and parity, but not pre-eclampsia or anaemia, are significant associated factors. The recurrence rate of abruptio placentae was 5.6%. There were no maternal deaths and the p... | 419,953 | [
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Emotional distress in morning-after pill patients. | The self-administered SCL-90 test was utilized to collect emotional distress data on 120 female patients requesting morning-after pill pregnancy interception. SCL prescores were significant in anxiety, guilt and depression factors. The 2-week post-treatment results showed a significant decrease in these factors. This t... | 419,959 | [
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Hyperthecosis syndrome. Clinical, endocrinologic and histologic findings. | Five patients were found to have hyperthecosis ovarii as evidenced by the presence of large lipid containing thecal cells in the ovarian stroma. The clinical picture was similar in all of them, featuring mild virilization, obesity and oligomenorrhea, with refractoriness to clomid therapy. Plasma FSH levels were low nor... | 419,961 | [
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Late complications of 7-0 polyglycolic (Dexon) sutures in cataract surgery. | The late complications of corneo-scleral wound healing after the 15th postoperative day were recorded in 108 routine adult cataract operations using 7-0 polyglycolic acid (Dexon) sutures and compared with 80 routine adult cataract operations using 9-0 monofilament nylon (9-10 Ethilon Nylon) sutures. In 37 eyes of the 7... | 419,974 | [
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Pilocarpine medication in open-angle glaucoma. A study using pilocarpine eyedrops and an ocular therapeutic system. | Two modes of topical pilocarpine therapy were applied to sixteen patients with open-angle glaucoma. A pilocarpine drop medication (2% solution four times daily) was compared to a constant and continuous supply of pilocarpine by a therapeutic delivery system (Ocusert P-40). The pressure reducing efficiency was studied i... | 419,977 | [
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Gastric acid secretion and water balance in the marine teleost Gadus morhua. | Gastric acid secretion was measured in unanaesthetized codfish surgically equipped with a catheter draining the stomach. The pylorus was ligated. Without perfusion of the intestine, or during perfusion with pure sea water (100% SW) or slightly diluted (67%) SW, gastric acid secretion was low ( less than 10 mumol H+/kg.... | 420,016 | [
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Transcapillary passage of albumin, effects of tissue cooling and of increases in filtration and plasma colloid osmotic pressure. | 'Initial' clearance of radiolabelled serum albumin was measured in the perfused, maximally vasodilated muscle vascular bed of rat hindquarters during tissue cooling, during increases in filtration and during changes in serum colloid osmotic pressure. Albumin clearance during ordinary serum perfusion at isogravimetry am... | 420,019 | [
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Vitamin B12 concentrations in psychiatric patients. | In an attempt to evaluate the possible relationship between vitamin B12 deficiency and mental disease, the blood content of vitamin B12 was investigated in 835 consecutive psychiatric patients. Low serum vitamin B12 values were found in approximately 10% of these patients, due to latent pernicious anaemia in one case, ... | 420,034 | [
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Depression and homicide. A psychiatric and forensic study of four cases. | Four examples of homicide followed by attempted suicide are presented based on the psychiatric examinations prepared for the use of the courts. Three cases were suffering from unbearable states of endogenous depression and the fourth showed a serious chronic neurotic depression following an acute grief reaction before ... | 420,039 | [
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Cross-sectional echocardiographic spectrum of papillary muscle dysfunction. | Cross-sectional echocardiography identified two abnormal patterns of mitral valve closure in 14 patients with mitral regurgitation due to papillary muscle dysfunction: (1) in three patients with an akinetic inferior-posterior wall but normal cavity size, papillary muscle fibrosis was associated with late systolic mitra... | 420,070 | [
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M mode and two dimensional echocardiographic features of porcine valve dysfunction. | The echocardiographic features are presented of degeneration of nine glutaraldehyde-fixed porcine xenograft valves implanted in eight patients. These features occurred 11 to 68 months after implantation and were correlated with surgical and necropsy findings. Acute bacterial endocarditis was present in two patients, an... | 420,101 | [
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Echocardiographic assessment of the effect of an antihypertensive regimen on left ventricular performance. | A regimen consisting of chlorthalidone, hydralazine and propranolol would be useful in some hypertensive patients with coronary artery disease or aortic dissection if it could be shown that reflex cardiac stimulation induced by hydralazine is completely neutralized by propranolol. Nine hypertensive patients were treate... | 420,108 | [
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The effect of iron and protein deficiency on the development of acquired resistance to reinfection with Nippostrongylus brasiliensis in rats. | Iron and protein deficiency delays the immunological rejection of Nippostrongylus brasiliensis from the small intestine of rats undergoing a primary infection with the parasite. In the present study, iron and protein deficiency significantly reduced acquired resistance to reinfection with N. brasiliensis. Repletion of ... | 420,147 | [
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Zinc metabolism in humans after oral and intravenous administration of Zn-69m. | Seventeen patients were studied after separate oral and intravenous administration of 50 muCi Zn-69m to determine if Zn-69m is suitable for studying zinc metabolism in humans and to determine if the route of administration affects kinetics. Patients stayed on a metabolic ward for each study. Activity was measured in th... | 420,148 | [
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Ultrastructure of the agent of Legionnaires' disease in the human lung. | This report confirms the gram-negative ultrastructural characteristics of the Legionnaires' disease organism by direct examination of pulmonary tissue from six confirmed cases--two from the original Philadelphia epidemic of 1976 and four from more recent sporadic cases. All microorganisms seen in all six lungs were ide... | 420,172 | [
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Risk of nutritional rickets among vegetarian children. | Records of the dietary intake of 52 preschool vegetarian children seen from 1974 to 1976 revealed that macrobiotic vegetarian diets provided amounts of vitamin D, calcium, and phosphorus that were marginal as well as less than the amounts provided by other vegetarian diets. Vitamin D supplements were rarely given. Two ... | 420,181 | [
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Hyperglycemic hyperosmolar coma in a 9-month-old child. | Hyperglycemic hyperosmolar coma is a life-threatening emergency with a mortality much higher than that of other forms of hyperosmolarity such as hypernatremia or diabetic ketoacidosis. Despite the differences in the three conditions, present evidence suggests that correction of hyperosmolarity should proceed slowly to ... | 420,189 | [
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Patient package inserts and the pharmacist's responsibility. | Patient package insert regulations by the Food and Drug Administration are discussed, emphasizing the pharmacist's responsibility. The possible criminal and civil liability problems the pharmacist may face under the regulations are considered. Legal implications of alternatives to using PPIs provided by the manufacture... | 420,215 | [
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Charging for hospital pharmaceutical services: computerized system using a markup and a dose fee. | The methods used to determine pharmacy charges for a pricing program in a 940-bed hospital using a computerized on-line pharmacy pricing and inventory control system are described. The program requires input of only four pieces of information: (1) patient number; (2) drug identification number; (3) dose factor; and (4)... | 420,229 | [
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Diffuse pulmonary infiltrates in immunosuppressed patients. Prospective study of 80 cases. | Over a two year period, we studied prospectively 80 cases of diffuse pneumonia at Memorial Sloan-Kettering Cancer Center. In 72 per cent of these, the patient had leukemia or lymphoma. Diagnostic procedures consisted of extensive serologic testing for antibody to known respiratory pathogens, including the agent of Legi... | 420,237 | [
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Orthostatic hypertension. | A 40 year old man was found to have marked hypertension when he was in the upright position with normal pressures when he was supine. Investigations disclosed normal catecholamine and renin levels. The baroreceptor reflex was somewhat depressed. The mechanism of this orthostatic hypertension is not known. The condition... | 420,246 | [
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Stress inoculation and interinstitutional transfer of mentally retarded individuals. | Forty-four mentally retarded individuals were studied to determine if relocation syndrome can be averted in interinstitutional transfer. Twenty-two persons who were transferred on a voluntary basis to a small, new, highly staffed facility and given individualized attention in preparation for the move were compared to a... | 420,262 | [
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Some correlates of language deterioration in severely and profoundly retarded long-term institutionalized residents. | Progress or deterioration in language use was observed in two samples of retarded institutionalized residents. One sample was observed twice, and the other three times, at 5-year intervals. We coded change in language use as noncommunicating, regressed irregular, stable, or progressed. Change in language use was found ... | 420,264 | [
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Flow dependence of nonelectrolyte absorption in the nephron. | The axial flow dependence of nonelectrolyte absorption was examined in terms of a model incorporating interactions between net volume absorption and both saturable and nonsaturable solute absorption. The model solutions demonstrated that changes in transepithelial solute transport are produced by changes in the average... | 420,297 | [
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Schizophrenic thought disorders: bizarre associations and intermingling. | The authors assessed bizarre verbalizations elicited from 37 schizophrenic and 16 nonschizophrenic patients. Interviews with subjects indicated that much bizarre schizophrenic language results from patients intermingling material from past and current experiences into their verbalizations. This intermingled material co... | 420,325 | [
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Response of patients to participation in psychiatry board examinations. | The patient who volunteers to be a subject for Part II of the certifying examination in psychiatry and neurology is an indispensable but surprisingly invisible participant in a highly controversial process. A survey of the attitudes of 78 patients toward this experience revealed that although they experienced a signifi... | 420,332 | [
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0.0470919,
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Blood pressure control in private practice: a case report. | High blood pressure is most commonly treated in the offices of private physicians. We have attempted to evaluate the efficacy of such care through review of all patient charts of a Board Certified, University Medical Center affiliated internist in New York City. Seventeen per cent had elevated (greater than or equal to... | 420,352 | [
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0.005189902,
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Paramedic programs and out-of-hospital cardiac arrest: I. Factors associated with successful resuscitation. | As part of an evaluation of whether the addition of paramedic services can reduce mortality from out-of-hospital cardiac arrest compared to previously existing emergency medical technician (EMT) services, factors associated with successful resuscitation were studied. A surveillance system was established to identify ca... | 420,353 | [
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0.1077421,
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Cut flowers: a potential pesticide hazard. | Following reports of ten cases of possible organophosphate pesticide poisoning in florists exposed to pesticide residues on cut flowers, we conducted a prospective random-sample survey to determine residual pesticide levels on flowers imported into the United States via Miami, Florida. A sample of all flowers imported ... | 420,356 | [
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Surgical treatment of partial Achilles tendon rupture. | Fifty-four patients with a total of 58 partial ruptures of the Achilles tendon were treated surgically. The postoperative observation time ranged from 8 months to 7 years. Forty-six patients indicated that they were pleased with the results, 8 were satisfied, and 3 were unsatisfied (one died during the interim). Thirty... | 420,383 | [
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Chondromalacia patellae in athletes. Clinical presentation and conservative management. | A comprehensive conservative management program for chondromalacia patella in athletes has been presented. The clinical manifestations and the efficacy of conservative treatment have been documented in the prospective study of 100 consecutive athletes. The over-all success rate was 82%, and 18% were considered to be fa... | 420,389 | [
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0.004270262,
... |
Urticaria and giardia lamblia infection. | A case of Giardia lamblia infestation with concomitent urticaria is presented. No mechanisms of association are suggested. With treatment of the Giardia, the urticaria cleared. The urticaria could also be suprressed with Atarax. | 420,425 | [
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Tuberculosis chemoprophylaxis practices in metropolitan clinics. | A survey of tuberculosis chemoprophylaxis policies was conducted from September 1977 through January 1978 of all metropolitan programs in the United States that reported more than 100 cases of tuberculosis during 1976. Twenty-eight programs were surveyed, and all responded. Uniform practice was found with regard to the... | 420,430 | [
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A national self-assessment program in internal medicine. | The Medical Knowledge Self-Assessment Program of the American College of Physicians is one of the largest continuing medical education programs in the United States. The scope and educational rationale for each of the components of the program are described. More than 32,000 physicians used one or more components durin... | 420,438 | [
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Non-Hodgkin lymphoma of the parotid gland: diagnosis, evaluation, and treatment. | Malignant lymphoma of the parotid gland not infrequently presents as a solitary mass indistinguishable from other commonly occurring lesions. Two new cases are presented here with a comprehensive literature review. When encountered, the lesion should be excised with the superficial lobe of the gland. If it is within th... | 420,485 | [
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0.008148... |
A new approach to the surgical treatment of reflux oesophagitis. | The rationale of combining proximal gastric vagotomy with Nissen fundoplication in the treatment of reflux oesophagitis due to hiatus hernia is discussed. The application of this procedure in 12 cases over a period of 4 years is described and the results, with a follow-up of 13--48 months, are reported. Ten of the 12 p... | 420,494 | [
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A data processing system for a group of three clinical chemistry laboratories. 1. Hardware and organisation. | A real time data processing system for a group of three clinical chemistry laboratories (one base and two satellite) has been developed as a successor to one used previously. This paper describes both the inadequacies of the previous worksheet-based system and the advantages of the new system, including flexibility, fa... | 420,500 | [
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... |
A data processing system for a group of three clinical chemistry laboratories. 2. File structure and operation. | In the preceding article the hardware and organisation of a new data processing system were described. This paper deals with the file structure and operation, the use of management information, the economical use of disc-file space and hardware, and the transferability of the system. | 420,501 | [
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0.01757579,
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An evaluation of a simple polyacrylamide gel electrophoresis system for lipoproteins and its use for the characterisation of hyperlipoproteinaemia. | The use of polyacrylamide gel electrophoresis as a screening procedure for the characterisation of hyperlipoproteinaemia is described. Sixty-one samples were investigated and classified by four different methods: (1) chemical profile derived from visual appearance and estimation of total cholesterol and triglyceride; (... | 420,503 | [
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... |
Behavioural deviance in children with early treated phenylketonuria. | A sample of 99 early treated phenylketonuric children showed higher levels of behavioural deviance than 197 matched controls. For boys this excess of behavioural deviance persisted when IQ was taken into account. For phenylketonuric girls however it was restricted to those with IQs less than 70. The type of behavioural... | 420,517 | [
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0.05496478,
0.03194848,... |
Housing and mothering: their effects upon the developmental levels of 3-year-old children. | The development of 200 3-year-old children was measured, using Gesell parameters of development. The levels of development were matched against the adequacy, or inadequacy, of maternal care and housing, the scales for which were derived from a questionnaire completed by the children's mothers. Housing was not found to ... | 420,522 | [
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Serum ceruloplasmin concentrations in rats with primary and transplanted sarcomas induced by nickel subsulfide. | Ceruloplasmin (CPN) concentrations were measured by p-phenylenediamine oxidase assay in serums from (a) 30 control Fischer rats; (b) 5 rats with primary sarcomas induced by i.m. injection of nickel subsulfide (alpha Ni3S2), and (c) 12 rats at intervals up to six weeks after s.c. transplantation of four alpha Ni3S2-indu... | 420,513 | [
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... |
The detection of creatine kinase isoenzyme CK1 in serum. | The brain isoenzyme of creatine kinase (CK) (EC 2.7.3.2) has been identified in the serum of 21 of 950 patients tested. Samples were received over a period of about 20 months. Analysis was performed by electrophoresis on agarose gel with isoenzyme bands visualized by fluorescence after enzyme coupled reactions producin... | 420,515 | [
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0.28... |
Light and electron microscopy of hepatocellular changes in griseofulvin fed mice. Particular reference to Mallory bodies. | Male Swiss Webster mice were fed a diet containing 2.5 percent griseofulvin (GF). Serially progressive light and electron microscopic hepatic altertions were present from one day on and grossly visible hepatomegaly from two weeks until termination at 22 weeks. GF induced liver changes included hepatocyte nuclear and cy... | 420,510 | [
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0.1251166,
0.04303942,
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Detection of antibodies to Salmonella "O" antigens in typhoid fever by counterimmunoelectrophoresis. II. Assessment in patients with typhoid fever and in a healthy population. | Two different population groups were studied. In one, 50 patients with a confirmed diagnosis of typhoid fever. Serum determinations were made for the detection of antibodies to S. typhi somatic antigen using Widal technique, surface fixation test and counterimmunoelectrophoresis (CIE). In the other group, 350 healthy s... | 420,535 | [
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0.1385682,
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Cognitive concomitants of hemispheric dysfunction in schizophrenia. | Forty-eight schizophrenics (24 paranoids, 24 nonparanoids) and 24 matched controls (12 men and 12 women in each group) were asked to detect the differences between 30 pairs of altered pictures presented successively (15 pairs) and simultaneously (15 pairs) in a counterbalanced order. Overall performance, as measured by... | 420,546 | [
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0.3337062,
0.02275467... |
[Benign solitary enchondroma (author's transl)]. | Solitary enchondroma is a benign bone tumor with a doubtful prognosis changing by topical but not by clinical, roentgenological or histological characteristics. Therefore benign solitary enchondroma should be subdivided in such of peripheral and such of central localisation. Both forms of enchondroma normally show an a... | 420,556 | [
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0.1231463,
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The epidemiology of primary osteoarthrosis of the knee in Greenland. | Two hundred ninety-five Greenlanders, 5% of the population of Greenland, aged 40 years or more, were investigated regarding primary osteoarthrosis of the knee. The pathological changes were categorized as mild, intermediate, or severe. Eighty-six (29%) of the patients were found to have osteoarthrosis and the mild form... | 420,561 | [
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... |
Computerized discharge summaries. | A computerized, English text discharge summary system is described that is exclusively used for all patients discharged from a 150-bed rehabilitation hospital. The system covers all diagnostic categories. Cumulative statistics and other statistical routines are provided for clinical research, utilization review and adm... | 420,567 | [
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Meralgia paresthetica: electrophysiologic study. | Conduction velocity of the lateral femoral cutaneous nerve was studied orthodromically. The mean value in 20 control subjects was 57.51 +/- 8.61 (SD) m/sec. In 9 patients with meralgia paresthetica, the sensory nerve condition in the symptomatic nerves was definitely abnormal: nerve potential was absent in 6 and condit... | 420,568 | [
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0.2247918... |
Plexiform neurofibroma infiltrating the facial nerve. | A plexiform neurofibroma was unusual in that it extensively infiltrated the main trunk and branches of the left facial nerve without compromising function, rather than forming a circumscribed, compressive mass. Histologic sections showed diffuse involvement of even minute branches of the facial nerve. Electron microsco... | 420,602 | [
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Metastatic intracranial seminoma. | A metastatic seminoma of the right temporal fossa, with facial pain, extraocular paresis, otitis, and abdominal symptoms, was found in a 34-year-old man one year after orchidectomy for a primary testicular tumor that had been treated by surgery and radiotherapy. This is an unusual intracranial metastatic tumor that mer... | 420,604 | [
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0.03953594,
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-0.0206... |
Pure memory loss with hippocampal lesions: a pneumoencephalographic study. | A case of pure memory loss occurred suddenly following inhalation anesthesia. Examination seven years after the onset of amnesia disclosed a profound and selective impairment of recent memory without concomitant deterioration of other higher functions or evidence of other neurologic abnormalities. Pneumoencephalotomogr... | 420,610 | [
0.1496769,
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Spirometry in amyotrophic lateral sclerosis. | Clinical evaluation and pulmonary function tests were performed in 218 patients with motor neuron disease, mainly amyotrophic lateral sclerosis (ALS). Serial studies were obtained in 103 patients, in 31 until death from ALS. Most patients, regardless of the pattern of motor neuron involvement, had characteristic abnorm... | 420,626 | [
0.01664999,
0.005907244,
0.171957,
-0.4040225,
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-0.2939979,
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0.3495554,
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0.2710508,
0.08155198,
0.107153,
0.1411322,
0.189123,
0.2106505,
-0... |
Thermal sweat rate response to an acute short exposure at a simulated altitude of 4,600m. | An acute short exposure of human subjects to a simulated altitude of 4,600 m fails to induce any noticeable effect on the thermal evaporative response or on the central and cutaneous temperatures. | 420,667 | [
-0.168183,
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Psychiatric consultation for the geriatric population in the general hospital. | The first part of this paper is based on a study by the author in 1975--1976. The conclusions were that liaison psychiatry with geriatric patients differs from that with other age groups in the following ways: (1) referrals occur primarily when behavior becomes disturbing; (2) organic causes are often overrated but psy... | 420,703 | [
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0.03223084,
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Increased toxoplasma antibodies in idiopathic inflammatory muscle disease. A case-controlled study. | Antibodies to Toxoplasma gondii were measured in sera from 69 patients with polymyositis, dermatomyositis, and myositis associated with other connective tissue diseases and compared to 69 age-, race-, and sex-matched controls with unrelated diseases. Complement fixation toxoplasma antibodies were significantly more fre... | 420,715 | [
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0.246898,
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0.2381614,
-0.3378115,... |
Estimates of maintenance requirement of growing lambs. | 1. Total body energy retention (ER) and metabolizable energy intake (MEI) values from experiments with 231 lambs (Suffolk male x (Border Leicester male x Cheviot female) female) housed indoors and given thirteen forage diets were used to estimate the metabolizable energy (ME) required for maintenance. 2. ER was measure... | 420,755 | [
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0.02527471,
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The relationship between hormonal balance and growth in malnourished children and rats. | Plasma concentrations of insulin, cortisol and growth hormone, and growth velocities have been measured in a group of Gambian village children up to 3 years of age. All three hormones showed changes in concentration with age, as did rates of growth. 2. Plasma insulin concentrations in the children were directly correla... | 420,764 | [
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0.05667381,
... |
Proton nuclear magnetic resonance study of cobrotoxin. | Cobrotoxin (Mr 6949), which binds tightly to the acetylcholine receptors, contains no phenylalanines and only two histidines, two tyrosines, and one tryptophan that result in well-resolved aromatic proton resonances in D2O at 360 MHz. His-32, Tyr-25, and the Trp are essential for toxicity and may interact with the acet... | 420,793 | [
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0.0574178,
0.104565,
0.3450221,
0.1413032,
0.2... |
Isolation of a minichromosome containing the ribosomal genes from Physarum polycephalum. | The ribosomal genes of Physarum polycephalum are located on linear DNA molecules (rDNA) of 38 x 10(6) daltons present in each nucleolus in 100--200 copies. The rDNA is not part of the large chromosomal DNA. These molecules have now been solubilized in the form of transcriptionally active deoxyribonucleoprotein complexe... | 420,794 | [
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0.05098648,
0.6583578,
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0.084509... |
[Fragmentation of chromatin by endogenous nucleases, accumulation of the subnucleosomal fragments with high electrophoretic mobility]. | Digestion of chromatin by endogenous nucleases to nucleosomes (140-160 base pairs of DNA) is accompanied by the accumulation of subnucleosomal DNP particles with high electrophoretic mobility (20-40 base pairs of DNA). All histones associate with the 140-160 base pairs fragment. The production of subnucleosomal DNP par... | 420,875 | [
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0.3470385,
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[Effect of cations on the quantum yield and the lifetime of the chloroplast fluorescence]. | The interrelationship between the cation-induced fluorescence changes and the state of the photosystem 2 (PS-2) reaction centers for pea chloroplasts and their osmotic fragments was studied. The effects of K+ and Mg2+ on the fluorescence quantum yield (phi f1) under varying light intensities as well as on the fluoresce... | 420,879 | [
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0.1025488,
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Quantitative analysis of morphological changes in skeletal muscle of the rat after hormone administration. | Thyroxine and cortisone acetate administration of rats of 4--7 days of age is not only accompanied by the induction of the muscle-specific enzyme, creatine kinase, but the hormones also induce morphological changes in the gastrocnemius during this period. Administration of thyroxine to these rats causes a splitting of ... | 420,882 | [
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... |
Minimal tissue concentrations of glutamate required to produce necrosis of hypothalamic neurons in newborn mice. | Groups of 4-day-old Cox Swiss albino mice were injected once subcutaneously with monosodium glutamate at several doses between 0.2 and 0.5 mg/g body weight. Glutamate, at a dose of 0.35 mg/g, produced neuronal necrosis of a very limited nature in only 60% of the animals and was defined as the minimal effective neurotox... | 420,883 | [
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0.3297438,
0.04346857,
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Quantitation of plasma warfarin levels by gas chromatography chemical ionization mass spectrometry. | A quantitative assay for plasma concentrations of warfarin has been developed using a deuterated warfarin analogue as internal standard. The method employs methylation (diazomethane) of warfarin to its 4'-methoxy derivative and gas chromatography chemical ionization mass spectrometry. Selected ion monitoring was used t... | 420,913 | [
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-... |
[Plasma erythropoiesis inhibitors in humans during hyperbaric hyperoxia]. | Before exposure of man to hyperbaric hyperoxia the blood plasma possessed marked erythropoietic activity. Erythropoietins disappeared completely and erythropoiesis inhibitors appeared in the plasma of persons untrained to hyperbaric hyperoxia after a 24-hour exposure to hyperoxic conditions (25% of oxygen in the inhale... | 420,929 | [
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0.2321335,
0.2079729,
0.2828605,
0.10119... |
Studies on mechanisms of 5-fluorouracil resistance in murine and human tumors. | An in vitro cell free assay system to measure phosphorylated products of 5-Fluorouracil is described. Total phosphorylated products and mono-, di and triphosphates of 5-Fluorouracil are measured along with the rate of fluorodeoxyuridylate generation. This assay has been applied to ten murine tumors and eight biopsy spe... | 420,947 | [
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Ara-C metabolism: implications for drug resistance and drug interactions. | Clinical studies of resistance to cytosine arabinoside have not produced agreement as to the specific biochemical lesions responsible for altered sensitivity, although experimental and clinical work supports the concept that a decreased ability to generate ara-CTP must be the ultimate effect of this lesion. 3-deazaurid... | 420,952 | [
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A curious occipital polyp. | Muscles which lose their attachments are uncommon. During development this normally occurs in certain muscles, e.g. the muscles of the face and epicranius; these muscles lose their skeletal connections before migration. In the case presented here a muscle in the occipital region had lost its attachment and formed a pec... | 420,965 | [
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... |
Colour lymphography in clinical surgery. | In 38 patients undergoing femoral artery profundaplasty and in 18 having simple mastectomy with pectoral node biopsy, a 6.2 per cent solution of sodium sulphan blue was injected peripherally to outline the lymph nodes in the groin or axilla. Nodes and vessels were easily seen and the technique is now in routine use. | 420,974 | [
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Sequential patterns of haemodynamic and metabolic changes in experimental hypovolaemic shock. II. Responses to reinfusion of shed blood. | The haemodynamic and metabolic effects which follow the infusion of blood in experimental hypovolaemia have not been studied in detail. The 10 dogs that survived 90 min of hypovolaemia in a study of bleeding (Pardy and Dudley, 1979) were investigated during and shortly after the reinfusion of shed blood using the same ... | 420,991 | [
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0.0369447,
0.0084... |
The lipid and protein content of cholinergic synaptic vesicles from the electric organ of Torpedo marmorata purified to constant composition: implications for vesicle structure. | The lipid, protein, acetylcholine and ATP content of cholinergic synaptic vesicles isolated from the richly innervated electric organ of Torpedo marmorata and purified to constant composition has been determined. The number of vesicles present in the preparations has been estimated by quantitative electron microscopy a... | 421,130 | [
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Congenital miosis. | The inheritance of congenital miosis in 2 pedigrees is described. The inheritance was autosomal dominant in one and autosomal recessive in the other. The pupils were 0.5-2.5 mm diameter, reacted normally to light and accommodation but dilated poorly with mydriatics. In both pedigrees, the affected members had enlarged ... | 421,161 | [
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0.008342611,
0.08304... |
Numbers of mast cells in the axillary lymph nodes of breast cancer patients. | This retrospective study of surgical specimens from forty-three consecutive patients treated by modified radical mastectomy for carcinoma of the breast shows that those patients surviving for at least sixty months after operation have a significantly greater number of mast cells in their axillary lymph nodes than the n... | 421,181 | [
0.09124531,
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N-(4-Hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat. | The synethesis of a new retinoid, N-(4-hydroxyphenyl)-all-trans-retinamide, which has useful biological properties, is described. This retinoid was more potent than retinyl acetate in reversing keratinization caused by retinoid deficiency in tracheal organ culture. It was markedly less toxic than retinyl acetate when f... | 421,218 | [
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... |
Effects of heat acclimation on the secretory products of the submaxillary gland of the rat. An ultrastructural and biochemical study. | Secretory granule area and glycoprotein concentration of the saliva in the submaxillary gland of rats were measured during various stages of acclimation to heat at 34 +/- 1 degrees C. Granule size decreased by 18% during the first five days of heat acclimation (0.025 less than p less than 0.05) after which period it in... | 421,246 | [
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0.005934464,
... |
Resorption of uncalcified cartilage in the diaphysis of the chick embryo tibia. | The resorption of the uncalcified cartilage matrix of the middle third of the diaphysis in the chick embryo tibia has been studied using histological, histochemical and electron microscopic techniques. The first stage in the resorption process affects the periosteal bone, which is breached by osteoclasts at one or seve... | 421,254 | [
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New observations on the fine structure of the liver in goldfish (Carassius auratus). | A re-examination of goldfish liver was made through the use of SEM of fractured samples and TEM of ultrathin-sections and freeze-etch replicas. Several new hepatic fine structures described in the present study are morphologically similar to those reported previously in many higher vertebrates including mammals. Hepati... | 421,256 | [
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Ultrastructural and histochemical investigation of the terminal capillaries in the spleen of the carp (Cyprinus carpio L.). | In the spleen of the carp arterial capillaries of a highly differentiated structure have been studied by light and electron microscopy. These capillaries share various structural characteristics with the sheathed capillaries (ellipsoids of Schweigger-Seidel) of higher vertebrates. The long arterial capillaries of the c... | 421,258 | [
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Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man. | We assessed the release of neuronal and adrenomedullary catecholamines in response to various stimuli of the sympathetic nervous system in normal subjects. Plasma catecholamines and their urinary metabolites, normetanephrine and metanephrine, were measured. Sodium restriction increased supine plasma norepinephrine by 3... | 421,304 | [
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-0.02121892,
0.06690104... |
Enzymatic determination of estradiol and estrone in plasma and urine. | Plasma and urine estradiol and estrone can be determined using the transhydrogenase function of the estradiol dehydrogenase of human placenta: in the conditions described the transhydrogenase activity which is directly related to the estrogen concentration is measured by spectrophotometry. Estrone and estradiol can be ... | 421,340 | [
-0.2668634,
0.11702,
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0.03413326,
0.1049327,
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0.03547875,
0.157974,
0.1897653,
0.279144,
0.04083715,
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0.5127287,
-0.3294902,
0.1229594,
0.2495248,
0.3595816,
0.05006724,
-0.28971... |
Lateral-view ventilation images with 133Xe. | For better delineation of regional ventilation abnormalities, a lateral-view imaging has been employed when one or more areas of abnormal retention were visible in posterior views of 133Xe washout images. It is technically simple to obtain lateral views during the 133Xe washout phase. The resulting images were found to... | 421,400 | [
-0.1186781,
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0.3211533,
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0.2262669,
0.2149279,
0.090078... |
Diffuse cord enlargement in radiation myelopathy. | Radiation myelopathy is a well-documented complication of the irradiation of neoplasms adjacent to the spinal cord. Myelography has been used to distinguish intraspinal metastases with the diagnosis of radiation myelopathy being made if the study is normal. Four cases of radiation myelopathy are here described which we... | 421,417 | [
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0.4828556,
0.195269,
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0.3823289,
0.2840132,
0.1562137,
... |
Glucagon as a hypotonic agent in cholangiography. | The effects of Glucagon on 35 cholangiographic studies was examined. Relief of spasm at the choledochoduodenal sphincter resulted in consistently improved demonstration of this area. Diminished spasm-induced pain was also recorded. The use of intravenous Glucagon is recommended for cholangiographic studies where there ... | 421,423 | [
0.1165628,
0.08579888,
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0.2737614,
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0.206404,
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0.0903583... |
The diagonal earlobe crease: a cutaneous manifestation of coronary artery disease. | Skin signs of systemic disease are of great interest to dermatologists. Reports based on coronary angiographic studies and postmortem examinations have shown that there is a higher prevalence of earlobe creases in patients with coronary heart disease. In this report seven patients with documented coronary heart disease... | 421,502 | [
0.01233821,
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0.2312125,
0.1382651,
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0.1912639,
0.4445415,
-0.11077... |
Thoracoscopy. A safe, accurate diagnostic procedure using the rigid thoracoscope and local anesthesia. | A thoracoscopic examination was performed in 41 patients under local anesthesia in the lateral decubitus position. Prior thoracocentesis (38 patients) and blind biopsy with an Abrams' needle (32 patients) had been nondiagnostic. The initial nine patients were examined with the flexible fiberoptic bronchoscope, yielding... | 421,522 | [
-0.07006112,
0.04090459,
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0.3708912,
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0.212098,
0.1271148,
-0.1677603,
0.2... |
Electrocardiographic axis deviation in Navajo and Apache indians. | It has been our clinical impression that the range of the mean frontal-plane electrocardiographic QRS axis was greater than might have been anticipated in healthy Navajo and Apache Indians. To determine whether this clinical impression was correct, electrocardiograms were obtained from 146 Navajo, 144 Apache, and 159 n... | 421,525 | [
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0.3611107,
-0.1089773,
-0.1199488,
0.1278651,
0.03574985,
-0.127274... |
Prolonged respiratory paralysis in wound botulism. | Two patients had wound botulism with longer duration of respiratory paralysis than previously described. Each sustained extensive trauma to soft tissues and grossly contaminated wounds when thrown from a vehicle in a rural area. Progressive muscular weakness and respiratory distress occurred 8 and 13 days after injury,... | 421,526 | [
-0.1055138,
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0.4513862,
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0.369728,
0.3754418,... |
Atrial myxoma mimicking a collagen disorder. | A 14-year-old boy had a protracted illness characterized by bilateral tenderness and weakness of the extremities; the illness was considered to be a connective tissue disease similar to polymyositis. Not until nine months later, when the patient had new cardiac murmurs, pulmonary edema, and then a cerebrovascular accid... | 421,537 | [
-0.5141885,
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0.2106982,
0.001278335,
0.04743744,
0.03703948,
0.4615873,
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0.04821694,
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0.1492997,
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-0.0009718376,
-0.3023744,
-0.04433606,
0.1158278,
-0.1166646,
-0.1966... |
Biopsy and brushing of peripheral lung cancer with fluoroscopic guidance. | Forty-eight patients underwent flexible fiberoptic bronchoscopic examination under fluoroscopic guidance, with biopsy and brushing of an endoscopically invisible primary cancer of the lung. A diagnostic (abnormal) specimen was obtained by biopsy of brushing (or both) in 29 patients (60 percent), by biopsy alone in 22 (... | 421,549 | [
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0.01499559,
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0.2031266,
-0.1484785,
-0.1448034,
0.328137,
0.009801061,
-0.07439189,
... |
Reexpansion pulmonary edema. | A case of pulmonary edema following reexpansion of a collapsed lung due to pneumothorax is described and illustrated. The importance of recognizing this relatively uncommon phenomenon is stressed. The development of such edema can be prevented by avoiding application of sudden and excessive negative pleural pressures d... | 421,556 | [
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0.06368486,
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0.0976534,
0.09495328,
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0.05071757,
-0.05336635,
0.03... |
Acute intoxication with verapamil. | A healthy 18-year-old man was admitted to our unit two hours after a suicidal ingestion of 2 gm of verapamil. There was mild hypotension, depression of the sinus node, atrioventricular dissociation, changes of repolarization, and first-degree intranodal atrioventricular block (the His bundle electrogram revealed an atr... | 421,559 | [
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0.2032471,
0.2529357,
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0.04444401,
0.4528051,
-0.01070744,... |
Traumatic injuries of the diaphragm. | Traumatic injury of the diaphragm is not an infrequent occurrence. With the rise in violence and increasing use of automobiles, more diaphragmetic injuries may be seen, especially in inner-city hospitals. Sixty-six cases from our institution within the last five years were reviewed. Of these there were 41 penetrating i... | 421,571 | [
-0.3476431,
0.2176213,
0.1311265,
0.09129298,
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0.4016415,
0.2860501,
-0.1888045,
... |
Incidence of ruptured chordae tendineae in the mitral valvular prolapse syndrome: an echocardiographic study. | Echocardiographic studies were performed in 190 consecutive patients with mitral valvular prolapse. All patients had either midsystolic posterior motion of the mitral valve or holosystolic hammock-like movement of the valve in systole. Thirteen patients (7 percent) were noted to have ruptured chordae tendineae. In four... | 421,575 | [
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0.1103203,
0.170742,
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0.7381384,
0.01861775,
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0... |
Congenital pulmonary artery branch stenosis: association with renal artery stenosis. | A patient had multiple bilateral stenoses of the pulmonary artery and its branches with systemic hypertension associated with mild stenoses of the renal arteries. Cardiac catheterization and angiocardiography are important in the evaluation of the degree of stenoses and pulmonary hypertension. This case suggests that i... | 421,591 | [
-0.09795943,
0.176798,
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0.2350422,
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0.2503575,
0.2400343,
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0.2093759,
0.08762584,
-0.1174015,
0... |
Legionnaires' disease presenting with empyema. | Legionnaire's disease presenting as empyema has not been previously described, although pleural effusions are not uncommon. A 56-year-old woman had a ten-day history of pleuritic chest pain and a large loculated empyema. Legionnaires' disease was documented by serum indirect fluorescent antibody studies. | 421,592 | [
-0.1947083,
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0.02102244,
0.1122728,
-0.2544118,
0.02242726,
-0.03016576,
0.003825846... |
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