title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Normophosphatemic phosphate depletion in growing rat. | To study the influence of phosphate depletion (PD) on the serum, urinary, bone, and soft tissue phosphorus, we studied growing rats given a high-phosphorus (HP), normal-phosphorus (NP), or low-phosphorus (LP) diet. We obtained the following results. a) With an LP diet, animals did not grow but developed the characteris... | 426,059 | [
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Kidney metabolite levels and ammonia production in acute acid-base alterations in the rat. | Acute acid-base disturbances cause rapid changes in renal ammonia production in the rat. To investigate the regulation of ammonia production in acute acid-base stresses, we examined the effects of such conditions on tissue levels of metabolites such as alpha-ketoglutarate (KG), which inhibits kidney mitochondrial gluta... | 426,060 | [
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Sympatho-adrenal responses of spontaneously hypertensive rats to immobilization stress. | Blood pressure, heart rate, and circulating levels of norepinephrine, epinephrine, and corticosterone were measured before and during the first or seventh period of immobilization stress (150 min per day) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive male rats. A catheter was inserted into the... | 426,081 | [
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Accuracy of ventricular lumen volume measurement by intraventricular balloon method. | To assess the accuracy of left ventricular volume measured by the intraventricular balloon method, we measured the space between the endocardium and the gradually inflated balloon in six Formalin-fixed canine left ventricles. The space was as small as 1-1.5 ml for intraballoon pressure of 100-200 mmHg and tended to inc... | 426,087 | [
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Plasma volume and electrolyte shifts with heavy exercise in sitting and supine positions. | Plasma volume (PV) and electrolyte shifts were measured before and for 60 min after a continuous peak oxygen uptake (VO2 peak) test in four men (26-45 yr) on a bicycle ergometer. Mean (+/-SE) sitting VO2peak (3.16 +/- 0.32 1/min) was the same as supine VO2peak (3.13 +/- 0.33 1/min). In recovery (R + 1.5 min), mean PV h... | 426,097 | [
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Plasma growth hormone: effect of anxiety during flooding in vivo. | The treatment of phobias by rapid in vivo exposure to the feared situation was accompanied by an increase in plasma growth hormone levels on at least one of two occasions in 8 of 11 subjects. The average growth hormone response was greater on the second occasion, even though subjective anxiety was less. Plasma growth h... | 426,105 | [
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Peer review of group therapy: Washington, D.C., 1972-1977. | The author discusses the evolution of psychiatric peer review in Washington, D.C. In its first six years (1972-1977) the Washington Psychiatric Society Peer Review Committee evaluated 146 cases, 23 (16%) of which focused on group therapy. Eight of these cases (35%) were partially or fully denied. Most of the cases invo... | 426,113 | [
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Depression treated with imipramine and ECT: the DeCarolis study reconsidered. | The authors reevaluate a large prospective Italian study (437 patients) that compared high-dose imipramine with ECT treatment in the treatment of depression. The superiority of ECT was evident among patients with endogenous depression, and especially evident among those with delusional depression (83% improved with ECT... | 426,143 | [
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The Ottawa County project: a report of a tuberculosis screening project in a small mining community. | Following a retrospective review of tuberculosis cases reported from Ottawa County, Oklahoma, from 1969 through 1973, a selective tuberculosis screening project was implemented. Screening of a "target group" of the population, 519 former miners, greater than or equal to 50 years of age, resulted in the discovery of abn... | 426,159 | [
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A retrospective and prospective study of serial CEA determinations in the early detection of recurrent colon cancer. | The results of the present study emphasize the importance of minimizing the time delay between a significant elevation in CEA and a second-look operation. Equally important are the frequency of serial determinations, a thorough understanding of the limitations of the assay, and careful evaluation of the clinical condit... | 426,170 | [
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A longitudinal study of tryptophan involvement in hepatic coma. | Previous cross-sectional studies have demonstrated that hepatic coma is associated with abnormally high levels of plasma free tryptophan. Establishment of a more definitive relationship between this biochemical abnormality and hepatic coma requires an evaluation of biochemical changes in individual patients as they und... | 426,181 | [
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Increasing incidence of right-sided lesions in colorectal cancer. | One hundred ninety-eight patients with 211 cancers of the colon and rectum underwent elective resection at the University of Vermont College of Medicine during the five year period 1971 through 1975. Analysis of this series demonstrated that 35 per cent of all cancers were located in the cecum and ascending colon, that... | 426,201 | [
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The Belsey operation for hiatal hernia: a twenty year experience. | A twenty year experience with the Belsey operation for hiatal hernia repair demonstrated good to excellent results in 80 per cent of patients, a fair outcome in 15 per cent, and unacceptable results in 5 per cent of patients. Good results included the absence of reflux symptoms, pleasant swallowing, the preservation of... | 426,203 | [
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A continuing saga of piped medical gas supply. | The development and present position of British Standards relating to Piped Medical Gas Supplies is considered with particular reference to the recommendations of the reports of the Kent and Canterbury and Westminster Inquiries. | 426,244 | [
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[Doltron ESA 1000. A new apparatus for electrostimulation-anaesthesia (author's transl)]. | The Doltron ESA 1000 apparatus is a constant current stimulator which delivers positive and negative rectangular pulses. On account of the safety precautions built in, which satisfy international standards, and adequate software this device appears suitable for electrostimulation anaesthesia. | 426,269 | [
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The differential absorptive activity of epithelial cells of the rat epididymus before and after castration. | Horseradish peroxidase introduced into the lumen of the rat epididymis was taken up by the columnar cells of the epithelium by five minutes and more so after longer periods. The apical cells and particularly the clear cells in the caput and cauda epididymis, respectively, showed significantly greater endocytotic activi... | 426,301 | [
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Scanning electron microscopy of bronchiolar neuroepithelial bodies in neonatal mouse lungs. | Scanning electron microscopy of the bronchiolar neuroepithelial bodies (NEB's) in the neonatal mouse lungs was undertaken and correlated with the accompanying transmission electron microscopy. The NEB's appeared as isolated organoids along the entire length of the bronchioles, and often were located at the branching po... | 426,314 | [
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Discriminate diagnostic peritoneal lavage in blunt abdominal injuries: accuracy and hazards. | The diagnostic peritoneal lavage for hemoperitoneum in blunt abdominal injuries is a safe test, and its high accuracy reported in unselected consecutive cases, is maintained equally in the clinically equivocal patients, the very group where one is expected to relay more decisively on the results of the D.P.L. | 426,366 | [
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[Local incidence of different types of dehydration (author's transl)]. | A total of 2,298 dehydrated infants, among 9,674 infants admitted to Emergency Unit and Intensive Care Unit of Clinica Infantil "La Paz" between 1970--1974 are analyzed. The annual incidence of the different types of hypotonic, hypertonic and isotonic dehydration is studied. The peculiarities of the data are discussed ... | 426,385 | [
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[Tricho-rhino-phalangeal dysplasia type I (Giedion's syndrome) (author's transl)]. | A new case of these rare entity is described. Histopathology and ultrastructure of cartilage is studied pointing out some pathogenics aspects. | 426,396 | [
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Whole body hyperthermia: a phase-I trial of a potential adjuvant to chemotherapy. | Fourteen patients with a variety of neoplasms not responsive to standard forms of therapy underwent whole body hyperthermia for a maximum 4 h at 41.8 degrees C. This was a phase-I cancer trial designed to develop whole body hyperthermia as an adjuvant to systemic chemotherapy. Intravenous analgesia was used to sedate p... | 426,399 | [
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BL-S786 (ceforanide), a new parenteral cephalosporin: in vitro studies. | BL-S786 (ceforanide) is a new cephalosporin which showed broad-spectrum activity in vitro against 453 clinical isolates. At a concentration of 3.12 mug/ml, it inhibited greater than 75% of isolates of Escherichia coli, Klebsiella spp., Proteus mirabilis, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus ... | 426,520 | [
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Blastomycosis-like pyoderma. | Seven patients with blastomycosis-like pyoderma had skin lesions of four months' to six years' duration. The criteria for the diagnosis of blastomycosis-like pyoderma include the clinical presentation of large verrucous plaques with multiple pustules and elevated border, pseudoepitheliomatous hyperplasia with abscess h... | 426,522 | [
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Harlequin ichthyosis with epidermal lipid abnormality. | An infant with phenotypic harlequin ichthyosis survived for nine months, then died a crib death. At autopsy, an enlarged, but structurally normal, thymus was found. Light microscopically, the epidermis showed massive hyperkeratosis and variable parakeratosis, and a stain for neutral fat was positive in the upper epider... | 426,527 | [
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Generalized malignant acanthosis nigricans. | We report a case of generalized malignant acanthosis nigricans (AN) secondary to metastasizing squamous cell carcinoma of the cervix uteri. The disease initially manifested in the perineum as condyloma acuminatum-like lesions. Subsequently, most of the cutaneous surface and the mucosa of the vulva, mouth, tongue, and t... | 426,529 | [
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The role of the peroneal artery for limb salvage. | Peroneal artery revascularization was performed in 61 cases for limb salvage and compared to a comparable group of 89 tibial artery reconstructions. Preoperative arteriography is essential to define runoff quality and pedal arch integrity. Intraoperative arteriography and flow determinations minimize failures due to te... | 426,551 | [
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Characteristics of the primary lesion of malignant melanoma as a guide to prognosis and therapy. | The histologic materal from the original lesion of 113 patients suffering from Clinical Stage I and Clinical Stage II malignant melanomas were reviewed in an attempt to correlate depth of invasion with prognosis and to test whether or not current methods of microstaging were a valid guide to therapy. Both the microstag... | 426,555 | [
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Surgical treatment in familial visceral myopathy. | In a kindred with a familial visceral myopathy, seven patients had operations seeking relief of chronic abdominal pain and other symptoms of intestinal obstruction; one patient had an 80% cystectomy and a Y-V-plasty of the bladder neck for urinary retention. Five patients with megaduodenum had bypass operations; a side... | 426,561 | [
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Studies on the macroconidia of Microsporum canis. Characteristics of in vitro amino acid incorporating system. | The characteristics of an in vitro polyuridylic acid dependent amino acid incorporating system prepared from germinating macroconidia of Microsporum canis are described. The incorporation of 14C-phenylalanine into polyphenylalanine is dependent on S-30 extract, adenosine triphosphate, magnesium ions and polyuridylic ac... | 426,600 | [
-0.2141142,
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0.06432698,
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0.2656828,
0.3932989,
0.06923966,
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... |
Patients' requests of an outpatient clinic. | Three-hundred-twenty-five consecutive predominantly lower-class new patients at a psychiatric outpatient clinic rated the importance they attached to each of 14 categories of treatment needs or requests. Psychiatric residents subsequently rated the importance of each request for each patient at the conclusion of their ... | 426,606 | [
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0.2528525,
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0.3453763,
-0.0341591... |
Transduodenal sphincteroplasty. | We report on the results of elective sphincteroplasty for benign stenosis of the sphincter of Oddi in a prospective study of 32 consecutive cases. All patients underwent combined supraduodenal exploration of the common bile duct and transduodenal sphincteroplasty. All patients were followed up clinically and biochemica... | 426,624 | [
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0.2557993,
0.3441648,
0.120843,... |
[Differential diagnosis of epithelial thymoma and seminoma (histological and electron-microscopic study)]. | The paper describes two observations of thymus gland tumours: epithelial thymoma and seminoma. Differential diagnosis of these tumours is very important for the proper selection of the method of treatment as seminoma is more radio-sensitive than epithelial thymoma. Epithelial thymoma is characterized by coarse-fiber st... | 426,635 | [
0.1045052,
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0.02834187,
0.4589007,
0.09106756,
0.1817961,
0.2... |
[Malignant tumors of lymphatic vessels in children]. | Lymphangiosarcomas were found in 5 out of 82 observations of vascular malignant tumours in children, according to the data of the pathological department of Children's Clinical Hospital No. 1, for 60 years. Differential diagnosis of relapsing lymphangiomas and rarely found malignant lymphangioendetheliomas presents con... | 426,636 | [
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0.3887722,
0.5385169,
0.1592023,
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0.14... |
Autosomal dominant dystrophy of the retinal pigment epithelium. | This study describes a salt-and-pepper fundus appearance in nine relatives in three generations of a single white kindred. Two of these patients also had subretinal patterned pigment figures by ophthalmoscopy. In another, fluorescein angiography showed a reticular pattern that was not apparent by ophthalmoscopy. This d... | 426,682 | [
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0.05043782,
... |
Ocular effects in normal rabbits of topically applied labetalol: a combined alpha- and beta-adrenergic antagonist. | The ocular effects in rabbits of topically applied labetalol hydrochloride, a new alpha- and beta-adrenergic receptor blocking agent, were studied. A dose-related reduction in intraocular pressure (IOP) followed treatment with 0.01% to 1% solutions. Labetalol at a 1% concentration had no effect on pupil diameter. The s... | 426,692 | [
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0.003004227,
0.03945006,
0.02312364,
0.1117726,... |
[Septal mucosa grafting for persistent drainage of the sphenoid sinus (author's transl)]. | In accordance to fundamental rhinologic rules following surgical intervention in the sphenoid sinus there should be established a persistent access from the nasal cavity by mucosal grafting. Suitable for this seem to be the septum's upper posterior areas. They are pedicled door-leaf-like dorso-laterally, folded into th... | 426,722 | [
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0.007370252,
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0.5621123,
0.04600903,
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Intraspecies heterogeneity of epidermal keratins isolated from bovine hoof and snout. | The alpha-keratins, the principal components of the tonafilaments, were extracted, characterized and compared in bovine hoof and snout epidermis. The alpha-fibrous proteins of these tissues are similar with respect to their molecular weights, amino acid composition and percentage of helical structure. However, distinct... | 426,768 | [
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0.2429287,
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Effect of anti-P1A1 antibody on human platelets. II. Mechanism of the complement-dependent release reaction. | We studied the mechanism by which complement activated by anti-P1A1 antibody elicits the platelet release reaction. Anti-P1A1 antibody mediates its action through the classic complement pathway, and its effect depends on the concentration of IgG antibody on the platelet surface. At relatively high concentrations of ant... | 426,908 | [
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0.1500268,
0.1984304,
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... |
[Carcinoid tumor of the appendix in children]. | Carcinoid tumor of the appendix has been known since 1808, and currently we know that it may appear all along the intestinal tract, biliary tree, ovaries, bronchi, lungs and pancreas. It is usually uncommon during infancy, representing 1.8% of all the tumors of the intestinal tract, approximately 70% of the appendiceal... | 426,923 | [
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0.315594,
0.1234599,
0.5033159,
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-0.01959433,... |
[Acrodysostosis]. | Two unrelated males of 16 and 8 years of age with acrodysostosis were studied. They showed short stature, broad and hypoplastic nose and severe acromelic shortness. X-ray studies revealed bilateral brachymetacarpaly, brachymetatarsalia and brachyphalangia with hyperplasia of the first ray in hands and feet. Psychometri... | 426,925 | [
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0.5033242,
0.01938859,
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[Genetic counseling of acrocephalosyndactylia]. | The present paper describes a case with clinical and radiological characteristics of Apert's syndrome. He was the first offspring from second cousins marriage. We considered that in this case, consanguinity is an associated feature. Perhaps this case may be the third one reported in the literature with consanguineous p... | 426,928 | [
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0.07598566,
-0.0892024... |
[Inhibition of nociceptive responses of spinal dorsal horn neurons by periaqueductal gray stimulation (author's transl)]. | In order to analyze analgesic effects of periaqueductal gray stimulation, experiments were carried out in nitrous oxide anesthetized cats. Spinal dorsal horn neurons receiving C-fiber inputs from the posterior tibial and/or superficial peroneal nerves were excited by noxious heat stimulation of the ipsilateral hindpaw.... | 426,934 | [
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0.1099164,
0.4215897,
0.1928648,
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0.006697442... |
Electrocardiographic changes resembling myocardial ischaemia in asymptomatic men with normal coronary arteriograms. | T wave and ST segment abnormalities in 20 asymptomatic men aged 18 to 55 were investigated because they were identical with myocardial ischaemic changes, and the professional livelihood of the subjects was jeopardised. Coronary arteriograms showed unobstructed arteries in all except one in whom a 50 per cent lesion of ... | 426,966 | [
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0.20582,
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0.3826543,
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... |
Left ventricular ejection power in coronary artery disease during atrial pacing. | Peak and mean left ventricular ejection power were measured during atrial pacing in 6 normal subjects (group I), 6 patients with coronary artery disease without myocardial infarction (group IIa), and 10 patients with coronary artery disease after myocardial infarction (group IIb). Pacing rates were 80 and 120/min. Powe... | 426,968 | [
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0.0373775,
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Open heart surgery in first year of life using profound hypothermia (core cooling) and circulatory arrest. Experience with 134 consecutive cases. | Between April 1970 and December 1977, 134 infants aged 2 days to 12 months underwent open heart surgery using profound hypothermia and total circulatory arrest. The technique of bypass (core) cooling is described. Results are reviewed for 4 principal diagnoses: 'simple' transposition of the great vessels, total anomalo... | 426,979 | [
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0.2736038,
0.5292841,
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Concentration of catecholamines in human cardiac muscle. | A trihydroxyindole fluorescent technique was used to measure the concentration of catecholamines in heart muscle taken from 42 patients undergoing open heart surgery. Noradrenaline was the dominant catecholamine and its depletion in the failing heart was confirmed. The distribution of catecholamines within the heart wa... | 426,982 | [
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Etomidate for induction of anaesthesia at caesarean section: comparison with thiopentone. | Thirty mothers undergoing elective Caesarean section received thiopentone 3.5 mg kg-1 and 30 received etomidate 0.3 mg kg-1 for induction of anaesthesia. Subsequent management of anaesthesia was identical in both groups. Maternal to fetal base excess differences and the degree of biochemical correlation between mother ... | 426,990 | [
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... |
Dose-related tachycardia induced by pancuronium during balanced anaesthesia with and without droperidol. | Pancuronium 0.02--0.08 mg kg-1 induced a dose-related increase of heart rate in patients anaesthetized with nitrous oxide supplemented with either fentanyl 0.003 mg kg-1 or fentanyl 0.003 mg kg-1 plus droperidol 0.15 mg kg-1. The tachycardia was more marked following the administration of droperidol. | 426,993 | [
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0.1297024,
... |
Bioavailability of conventional and slow-release oxprenolol in fasted and nonfasted individuals. | 1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow-release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half-lives were longer after food with conventional tablets... | 427,007 | [
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... |
Twenty-nail dystrophy of childhood. Case report and histopathological findings. | A case of twenty-nail dystrophy of childhood is reported. The histopathological findings were distinctive and incompatible with the notion that this condition might be a variant of lichen planus. | 427,021 | [
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0.... |
Erythrocyte membrane lipid reorganization during the sickling process. | In order to study possible alterations in membrane lipids during sickling, we have measured the difference in susceptibility to lipid peroxidation, binding of trinitrobenzenesulfonic acid (TNBS) to aminophospholipids, and fatty acid uptake in cells containing sickle haemoglobin under aerobic and anaerobic conditions. W... | 427,032 | [
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0.1863499,
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0.5992837,
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Activity and characterization of a low molecular fraction present in human amniotic fluid with broad spectrum antibacterial activity. | The isolation of a low molecular weight fraction from amniotic fluid with broad spectrum antimicrobial activity is reported. This fraction consists of a family of peptides whose bactericidal activity is zinc dependent and can be inhibited by phosphate. Peptides are present in early gestation in low concentration increa... | 427,056 | [
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The measurement of food iron absorption in man. A methodological study on the measurement of dietary non-haem-Fe absorption when the subjects have a free choice of food items. | 1. The present study was considered as a first step to develop a method to measure food iron absorption from realistic common meals prepared and consumed by the subjects themselves in their own homes. The absorption of Fe from the meals was measured by means of the extrinsic-tag method modified to allow for a free choi... | 427,081 | [
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0.1649646,
0.282595,
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0.14... |
Effect of dietary composition and cold exposure on non-shivering thermogenesis in young pigs and its alteration by the beta-blocker propranolol. | 1. Young pigs were fed on three diets consecutively, each diet being given for 1 week. The diets were given in random order as (g pig feed/kg body-weight): (a) 20, (b) 60, (c) 20 plus a supplement with the energy equivalent of 40 g pig feed/kg. The supplements included desiccated coconut, fish meal and glucose. 2. At t... | 427,088 | [
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0.3518898,
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0.1746999,
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Superoxide dismutase (EC 1.15.1.1), zinc status and ethanol consumption in maternal and foetal rat livers. | 1. The activity of superoxide dismutase (EC 1.15.1.1) was not greatly affected by zinc deficiency in maternal or foetal (20 d) rat livers, although in the latter tissue it did appear to be slightly raised by Zn depletion when compared with pair-fed control animals. 2. Enzyme activity was significantly higher in livers ... | 427,092 | [
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-0.... |
Absorption changes of P-700 reversible in milliseconds at low temperature in Triton-solubilized photosystem I particles. | Triton-solubilized Photosystem I particles from spinach chloroplasts exhibit largely reversible P-700 absorption changes over the temperature range from 4.2 K to room temperature. For anaerobic samples treated with dithionite and neutral red at pH 10 and illuminated during cooling, a brief (1 microseconds) saturating f... | 427,139 | [
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0.08921204,
0.02211936,
0.1551099,
0.3015361,
-0.1305746... |
Transepithelial permeability in the rabbit pancreas. | 1. The transepithelial permeability in the isolated rabbit pancreas has been studied with the aid of radioactive markers added to the bathing medium. 2. After addition of these compounds in 2 mM concentration to the medium, they equilibrate within 30 min to a steady-state concentration in the secreted fluid. The latter... | 427,155 | [
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Two modes of aggregation of artificial H1-DNA complexes depending on the rate of decrease of ionic strength. | The properties of H1-DNA artificial complexes, formed at different rates of decrease of NaCl concentration from 0.9 to 0.15 M, were investigated. It was found that two distinct processes, both depending on the rate of the concentration decrease, lead to the formation of aggregates differing in: the ability to form sedi... | 427,159 | [
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DNA polymerases in mouse spermatogenic cells separated by sedimentation velocity. | Activity levels of DNA polymerase alpha and DNA polymerase beta have been measured in mouse spermatogenic cells separated by sedimentation velocity. Testes from prepuberal (17 day old) and sexually mature mice were dissociated and separated by unit gravity sedimentation into 6 populations of cells. Phase contrast micro... | 427,162 | [
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Incorporation of labelled amino acids into proteins of isolated parenchymal and nonparenchymal rat liver cells in the absence and presence of ethanol. | Parenchymal and nonparenchymal cells were isolated from perfused rat livers and incubated at 37 degrees C in the absence and presence of ethanol (50 mM). 1. Nonparenchymal cells prepared by means of centrifugation showed a higher rate of incorporation of L-[U-14C]valine into protein than nonparenchymal cells prepared b... | 427,167 | [
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Evidence for rate-limiting steps in sterol synthesis beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human leukocytes. | When human blood leukocytes are incubated with [2-14C]acetate only about 32% of the nonsaponifiable lipid radioactivity is recovered in digitonin-precipitable material. Using thin-layer chromatography and gas-liquid radiochromatography, we have determined that most of the label from [2-14C]acetate in the nonsaponifiabl... | 427,182 | [
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X-ray diffraction study of bovine lens capsule collagen. | The wide angle X-ray diffraction pattern of air-dried lens capsule collagen under tension is the same as the tendon collagen diffraction pattern with regard to the main reflections, and indicates that lens capsule collagen has the characteristic three-stranded helical structure with an axial repeat of 0.29 nm as tendon... | 427,197 | [
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Clearance of circulating desialylated thyroglobulins in the rat. | Canine and rat thyroglobulins were labeled with 125I either in vitro or in vivo, and were utilized for plasma clearance studies performed with rat. The half-life of physiologically radioiodinated asialothyroglobulins was about 6 min, while that of chemically radioiodinated asialothyroglobulin was about 12 min. No marke... | 427,223 | [
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The turnover catabolism and excretion of folate administered at physiological concentrations in the rat. | This study examines the distribution of folate-derived compounds in rat urine on a daily basis after the administration of tracer doses of radioactive [3H]pteroylglutamic acid. The identification of 10-formyldihydropteroyl-glutamate in the rat urine, prior to equilibration of the tracer, is also reported for the first ... | 427,225 | [
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Estimation of signal and noise spectra by special averaging techniques with application to a posteriori "Wiener" filtering. | This paper deals with the problem of separating the spectra of signal and noise in ensembles where the signal can be considered as an invariant component and the noise as a stationary additive background. Several methods are discussed and compared on the basis of a statistical analysis of the first two moments of the e... | 427,230 | [
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A model for processing of movement in the visual system. | Processing of spatio-temporal information in the human visual system has been investigated thoroughly during the past decade, but is still far from being properly understood. Moreover, the theory of separation of information by means of sustained and transient channels already at the retinal level is not satisfactory, ... | 427,231 | [
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Kinetics of the helix-coil transition of a polypeptide with non-ionic side groups, derived from ultrasonic relaxation measurements. | Ultrasonic absorption and velocity dispersion curves have been measured in the temperature induced helix-coil transition range of poly-N5-(3-hydroxypropyl)-L-glutamine in a methanol/water mixture. The results clearly reflect an effect due to the kinetics of the conformational conversion. A practically single relaxation... | 427,245 | [
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Suction capillaries with U-shaped opening for holding moving cells during intracellular electrical recording. | The production of suction capillaries with an U-shaped cross-section is described. The capillary may be used for holding contractile cells during intracellular recording to diminish movement artifacts. In addition microelectrode penetration is facilitated by stretching the surface of the cell. | 427,250 | [
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[Antiarrhythmic and electrophysiological properties of etmozin and its diethylamine analog]. | Effects of antiarrhythmic drug etmosin and its diethylamine analogue (etmosin DAA) were compared in dogs with the ventricular rhythm disturbances induced by coronary artery ligation according to Harris' method. As demonstrated, both drugs stopped ventricular rhythm disturbances, but etmosin DAA had a more rapid and pro... | 427,276 | [
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[Pharmacogenetic aspects of the immunodepressive action of cyclophosphamide]. | The alkylating and immunodepressive activity of the serum of CBA, BALB/c and DBA/2 mice was studied after the cyclophosphamide administration. The interstrain differences between the indices under study were revealed; no direct correlation was shown between them. DBA/2 mice were found to be the most sensitive to the im... | 427,277 | [
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[In vitro production of hemopoietic stem cells: washings from organ cultures of embryonic liver]. | Hemopoietic cells including CFUs could be washed off from the organ culture of fetal liver periodically for 4 weeks. Under the cultivation conditions employed this treatment did not reduce the CFUs content of the culture essentially; thus, the washings off could be used to elevate the CFUs yield per culture. | 427,281 | [
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Responses of small rabbit pial arteries in vitro. | An in vitro method for measuring changes in isometric force of vessels as small as 100 microns in outer diameter was used to determine whether the adrenergic mechanism of small pial arteries is the same as the large arteries of the circle of Willis. Fluorescence histology demonstrated the rich noradrenergic innervation... | 427,284 | [
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Successful replantation of a totally avulsed scalp. | A case of a totally avulsed scalp was replanted successfully by microvascular anastomosis. Though the avulsed part was heavily crushed, which resulted in a central wound, the appearance of a "necrotic" area, haematomas and persistent serous exudation after the restoration of circulation, the whole scalp survived. | 427,303 | [
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Conversations with chronic schizophrenic patients. | An account is given of some of the topics discussed during a small informal weekly open group meeting of chronic schizophrenic patients, based on occasional notes compiled over eleven years. The main feature of the patients' condition as displayed was poverty--clinical, social, behavioural, material and financial--and ... | 427,336 | [
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Bone densitometry using computed tomography. Part I: selective determination of trabecular bone density and other bone mineral parameters. Normal values in children and adults. | Gamma-ray computed tomography (gamma-ray CT), using a special purpose scanner, enables in-vivo quantitative analysis of bone mineralization. Trabecular bone density (TBD), the relative amount of compact bone (bone density, BD) and the total absorption (TA) for a cross-section of the radius are determined from measureme... | 427,345 | [
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Bone densitometry using computed tomography. Part II: increased trabecular bone density in children with chronic renal failure. | The method of gamma-ray computed tomography (gamma-ray CT) bone densitometry described in the preceding article provides selective determination of trabecular bone density (TBD), the relative amount of compact bone (bone density, BD), and the total absorption (TA) within a bone cross section. Seven of nine children wit... | 427,347 | [
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A single injection technique for subtraction of blood background in 131I-hippuran renograms. | A method of subtracting blood background during proberenography is presented which does not require a prior injection of RIHSA and which produces results approximately 11% higher than the RIHSA method. The new method treats the renogram up to two-and-a-half minutes as a combination of a fraction of the blood curve and ... | 427,364 | [
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Hyperosmolar diabetes presenting as acute urinary retention: report of three cases. | Three elderly patients presented at one hospital in a 2-week period with acute urinary retention precipitated by the hyperosmolar non-ketotic diabetic state. In each case routine urine testing was reported as showing 1 per cent glycosuria. The first two patients were admitted at night and blood glucose estimations were... | 427,390 | [
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Haematogenous osteomyelitis of the metatarsal sesamoid. | A case of haematogenous osteomyelitis of the medical first metatarsal sesamoid is presented and the differential diagnosis discussed. Review of the literature suggests that the condition is rarely seen and tends to present in childhood and adolescence. This contrasts with metatarsal sesamoid osteomyelitis due to direct... | 427,392 | [
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Smoking and subarachnoid haemorrhage. | A retrospective study of 208 patients with ruptured cerebral aneurysms showed a highly significant excess of cigarette smokers among both men and women compared with the expected incidence. Results suggested that continued smoking increases the risk of suffering a subarachnoid haemorrhage (SAH) by a factor of 3.9 for m... | 427,449 | [
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... |
Malignant hypertension and cigarette smoking. | The smoking habits of 48 patients with malignant hypertension were compared with those of 92 consecutive patients with non-malignant hypertension. Thirty-three of the patients with malignant and 34 of the patients with non-malignant hypertension were smokers when first diagnosed. This difference was significant, and re... | 427,451 | [
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Medical manpower two years on. | Medical manpower in Britain, with particular reference to the NHS, was analysed for 1976 and 1977. The output of British medical schools increased. The total of doctors in the NHS rose by 2% between 1975 and 1976 and by 2.4% between 1976 and 1977. The highest and lowest growth rates were in junior and senior hospital s... | 427,459 | [
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The spontaneous firing patterns of forebrain neurons. IV. Effects of bilateral and unilateral frontal cortical ablations on firing of caudate, globus pallidus and thalamic neurons. | To assess the effects of partial deafferentation of the neostriatum on spontaneous neuronal activity in the basal ganglia and related thalamic nuclei, ablations of frontal cortex were carried out in adult cats. Postoperative measures of interspike intervals of single neurons in the caudate nucleus, globus pallidus and ... | 427,584 | [
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Effects of endorphins on single myenteric neurons. | Methionine-enkephalin, leucine-enkephalin and beta-endorphin were applied in known concentrations to an in vitro preparation of myenteric neurons from the guinea-pig ileum. All 3 substances caused a rapid, reversible and dose related inhibition of the firing of myenteric neurons induced and recorded with extracellular ... | 427,587 | [
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0.06420821,
0.2069163,
0.1963605,
0.09406999,
0.239061,
0.1829441,
... |
Adrenaline levels in brain stem nuclei and effects of a PNMT inhibitor on spontaneously hypertensive rats. | The adrenaline content of specific brain stem areas was decreased in young (4 week-old) but not in adult (14 week-old) SHR. Some of these areas also showed increased PNMT activity, indicating a possible enhanced release or metabolism of adrenaline early in the development of the hypertension. Dopamine and noradrenaline... | 427,591 | [
-0.0648763,
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0.138158,
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0.4369201,
0.05279209,
0.2133932,
-0.1538209,
0.019... |
Evaluation of an improved rapid coagglutination method for the serological grouping of beta-hemolytic streptococci. | Grouping of beta-hemolytic streptococci was performed with the Phadebact Streptococcus Test, a coagglutination method, and the results compared with serological grouping by the standard Lancefield precipitin method. Of 171 clinical specimens examined, 169 (98.8%) were grouped correctly by the Phadebact Test after 24 h ... | 427,654 | [
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0.1050146,
0.4999276,
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0.00547074,
... |
Survey of the clinical use of pressurized aerosol inhalers. | Questions as to the use of pressurized aerosol inhalers were asked of 130 persons presenting for routine pulmonary function studies who had used such a device in the previous year. After spirometry was conducted the subjects used the inhaler; they were unaware that their technique of use was being observed. Only 10.8% ... | 427,689 | [
-0.1299229,
0.05539994,
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0.194275,
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0.1133214,
0.26591,
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0.04625809,
-... |
A mental health system in transition: profiles of change. | These profiles of the changing Saskatchewan mental health system reveal that there have been increases in the number of admissions, readmissions, discharges, and outpatients in both the public and private sectors. Divergent patterns in the utilization of services in the public sector occur among the Indian and non-Indi... | 427,698 | [
-0.07048868,
0.1582801,
0.1594859,
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0.2012974,
-0.1969732,
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0.02159476,
-0.06033... |
Suicide in Newfoundland and Labrador. | The present investigation was undertaken to explore the special factors associated with low suicide rates in Newfoundland and covered the ten year period of 1964 to 1973. The data were collected from death certificates. Comparisons were made with figures for Canada as a whole, as reported in the official statistics. Ap... | 427,700 | [
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0.0932776,
0.1409103,
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0.2896753,
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0.04837919,
0.6401682,
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0.2... |
Conservation surgery and irradiation for the treatment of favorable breast cancer. | The results in 162 patients with clinically favorable breast cancer treated with conservation surgery and radiation therapy are presented. The surgical procedures were simple excision with and without positive microscopic margins, segmental mastectomy, and segmental mastectomy with axillary dissection. Details of the r... | 427,713 | [
-0.03446974,
0.103266,
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0.1280774,
0.0778329,
0.1985231,
0.04908073,
0.4196903,
0.08712545,
0.02388491,
0.1... |
The results of treatment of perineal recurrence of cancer of the rectum. | A study of 36 patients with adenocarcinoma of the rectum recurrent in the perineum after Miles abdominoperineal resection defined a subgroup of 21 patients in whom curative re-excision of the perineum, with or without associated resection of viscera as warranted by operative findings, was performed. Recurrence without ... | 427,735 | [
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0.1265691,
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0.03980684,
0.004907303,
0.1757877,
0.112568,
0.0888829,
0.2920677,
-0.01936305,... |
Induction of differentiation of Rauscher virus-induced mouse myeloid leukemia cells with a factor(s) in ascitic fluid and inhibitors of nucleic acid and protein syntheses. | Cell line R453, established from a Rauscher virus-induced myeloid leukemia in a C57BL/6 mouse, was induced to differentiate in vitro into macrophages and granulocytes with ascitic fluids from animals bearing various ascites tumors or from mice treated with complete Freund's adjuvant, conditioned media from various cell... | 427,746 | [
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0.3814814,
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0.09331556,
0.16162,
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0.03419342,
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0.564703,
0.1431183,
-0.2978006,
-0.3754169,
... |
Effects of iodine deficiency and high-fat diet on N-nitrosomethylurea-induced mammary cancers in rats. | The effects of an altered content of dietary iodine and fat on the development of N-nitrosomethylurea-induced mammary tumors in rats were studied and correlated with thyroid and pituitary function studies. In three separate experiments, animals fed a semisynthetic diet containing 11.8% fat had an earlier time of tumor ... | 427,760 | [
-0.1993411,
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0.01739244,
0.225641,
0.040743,
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-0.1352672,
0.00476852,
-0.1462949,
0.16542,
0.08231458,
0.3228993,
-0.1792865,
... |
Incidence and pathological features of spontaneous tumors in athymic nude mice. | Systematic observation of 1141 nude mice (Swiss background [corrected] strain) that received human tumor transplants revealed 24 spontaneous tumors, 18 of lymphoreticular origin and 6 pulmonary adenomas. Spontaneous tumors were seen at an average age of 9.1 months, and 22 of the tumors were seen only in that fraction o... | 427,772 | [
-0.1591611,
-0.3776632,
-0.3676345,
-0.1735556,
0.1101695,
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0.08535948,
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0.2000296,
0.3226842,
0.3367648,
0.3824827,
-0.16936... |
Isolation and immunochemical characterization of antibodies from the sera of cancer patients which are reactive against human melanoma cell membranes by affinity chromatography. | Immunoglobulins were isolated by affinity chromatography from sera of two patients with melanoma, one with sarcoma, and one with carcinoma. The affinity columns were prepared by covalently linking the membrane-rich fraction of biopsied melanoma cells to cyanogen bromide-activated agarose beads. The membrane-rich fracti... | 427,806 | [
-0.3302091,
-0.0563076,
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0.0269499,
0.3542419,
0.2901444,
0.1049955,
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0.1... |
Increased excision of O6-methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine. | Male BDIV rats were given dimethylnitrosamine (2 mg/kg daily) by stomach tube on weekdays for a total of 9 weeks, the final dose being of 14C-labeled material. Control rats received only the labeled dimethylnitrosamine. Liver DNA was isolated at various times later (from 2 to 12 hr), and normal and alkylated purines we... | 427,812 | [
-0.206964,
0.04662095,
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0.0882262,
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-0.3741501,
0.05991939,
0.2969421,
0.2733718,
0.4020951,
0.04638102,
-0.03575394,
... |
Growth and treatment of Ehrlich tumor in mice with alloxan-induced diabetes. | Hypoglycemia and hypoinsulinemia accompanied i.p. or i.m. growth of the Ehrlich tumor in CBA/H and BALB/c mice. Simultaneously, insulin accumulated in the ascitic fluid of tumor-bearing mice. In hosts rendered diabetic by means of alloxan, the tumor decreased the blood glucose almost to the level seen in nondiabetic mi... | 427,813 | [
-0.1923005,
-0.3776264,
-0.2523409,
-0.1645442,
0.2156697,
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0.316599,
0.0310588,
0.09736524,
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0.3015093,
0.4430089,
-0.08950313,
0.0653400... |
Experimental antitumor activity of aminoanthraquinones. | The activity of a number of substituted alkylaminoanthraquinones was compared in transplanted murine tumor systems including P388 and L1210 leukemias, B16 melanoma, and colon carcinoma 26. The structure-activity relationships among this class of compounds are discussed. Several derivatives had very high antitumor activ... | 427,824 | [
-0.5275805,
0.0384104,
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0.2257809,
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0.4657906,
0.7772988,
0.04704472,
-0.1317692,
... |
Important clinical pharmacologic considerations in the use of methadone in cancer patients. | The manufacturer's recommended dose of methadone, which is 2.5-10 mg every 3-4 hours, is excessive. Methadone has an average primary-phase half-life of 14.3 hours and a slower secondary-phase half-life averaging 54.8 hours. Administering the recommended dose of methadone and escalating doses within 2-3 days may lead to... | 427,826 | [
-0.3988732,
0.2220589,
-0.3896435,
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0.1157407,
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0.1636022,
0.2098331,
0.3468245,
0.04239585,
0... |
Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125. | The antimetabolite antibiotic L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) showed significant antitumor activity against L1210 and P388 mouse leukemias and the M5076 mouse ovarian tumor. Depending on the schedule of administration, increases in lifespan of greater than 100% were observ... | 427,827 | [
-0.1461927,
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-0.06608208,
0.1404316,
-0.01289539,
0.1049379,
0.5267134,
0.2905183,
-0.26284... |
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