title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Treatment and sequelae of angiographic complications in children. | Fourteen cases of thromboembolic complications appeared in 267 consecutive angiographies during a 7-yr period. The arterial circulation has been evaluated both clinically and with oscillometry. The complication rate was substantially higher after cut down then after percutaneous approach (56% vs. 2.7%). Seven patients ... | 458,539 | [
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Bacterial peritonitis in patients with ventriculoperitoneal shunt. | Bacterial peritonitis is an unusual complication of ventriculoperitoneal (VP) shunt for hydrocephalus. This complication, usually associated with peritoneal cysts of perforated viscus, may occur as the first manifestation of shunt infection. Early recognition of this form of bacterial peritonitis and appropriate antibi... | 458,542 | [
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Ambient temperature and the occurrence of collective violence: a new analysis. | Prevalent folklore suggests that riots tend to occur during periods of very hot weather. Baron and Ransberger examined 102 major riots in the United States between 1967 and 1971 and concluded that the frequency of collective violence and ambient temperature are curvilinearly related. The present article points out that... | 458,551 | [
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Fitting concentration--time data to biexponential equations. | A digital computer study using simulated data containing random error indicates no difference in the precision and accuracy of parameter estimation when the data are fitted to several different equations. | 458,559 | [
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Chemistry of 8-chloroberberine. | 8-Chloroberberine (V), obtained by treatment of oxyberberine (I) with phosphorus oxychloride, is a reactive intermediate. Treatment with ammonia, methylamine, n-propylamine, aniline, and p-toluidine furnished the 8-berberinylidene derivatives IV and VII-X. Reaction of V with malononitrile, ethyl acetoacetate, and ethyl... | 458,568 | [
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Pharmacokinetics of morphine and its surrogates. III: Morphine and morphine 3-monoglucuronide pharmacokinetics in the dog as a function of dose. | The pharmacokinetics of morphine and its derived metabolite, morphine 3-monoglucuronide, were studied in normal and bile-cannulated dogs. High doses (7.2-7.7 mg/kg iv) caused renal and biliary shutdowns and time lags in urinary drug and metabolite excretion and in biliary secretion of the hepatically formed conjugate. ... | 458,581 | [
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Monoamine oxidase inhibition by beta-carbolines: a quantum chemical approach. | Monoamine oxidase inhibition by beta-carboline derivatives is related to the energy change, delta E, arising from complex formation between the inhibitor and the enzyme. The energy change was expressed in terms of electronic indexes, which were estimated for a set of aromatic beta-carbolines. The electronic indexes wer... | 458,582 | [
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Progestin permeation through polymer membranes III: Polymerization solvent effect on progesterone permeation through hydrogel membranes. | Hydrogels prepared from poly(hydroxyethyl methacrylate) are biocompatible and highly permeable to low molecular weight solutes. Permeation rates can be varied by altering the cross-linker concentration or using copolymers; the latter are chosen to alter the hydrogel equilibrium hydration. These factors suggest that hyd... | 458,587 | [
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Pyridones as potential antitumor agents. | Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active. At least two oxygen-containing functional g... | 458,596 | [
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Cefoxitin sodium: solution and solid-state chemical stability studies. | Studies were undertaken to provide the basic physicochemical information necessary for preparing a suitable parenteral formulation of cefoxitin sodium. Emphasis was placed on the physico-chemical properties of the compound in solution and in the solid state. Cefoxitin sodium is very soluble in water and exhibits appare... | 458,604 | [
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High-performance liquid chromatographic assay for the anthelmintic agent mebendazole in human plasma. | A rapid and specific high-performance liquid chromatographic (HPLC) assay for quantitative plasma mebendazole determination is described. After a simple extraction, the compound was analyzed by HPLC using a reversed-phase column and a UV detector (313 nm). Quantitation was accomplished using an internal standard; peak ... | 458,609 | [
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Cytotoxic saponins from the Chinese herbal drug Yunnan Bai Yao. | Two cytotoxic saponins were isolated from the acetone extracts of the herbal preparation "Yunnan Bai Yao" by column chromatography. They were identified as a 3-([alpha-L-rhamnopyranosyl()Rha leads to 2Glu)]-[alpha-L-arabinofuranosyl(1Ara leads to 4Glu)]-beta-D-glucopyranosyl)-25(R)-spirost-5-en-3beta-ol (I) and 3-([alp... | 458,613 | [
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Fluorometric determination of chlorzoxazone in tablets and biological fluids. | A fluorometric determination for chlorzoxazone was developed based on the intrinsic drug fluorescence in chloroform using excitation and emission wavelengths of 286 and 310 nm, respectively. A calibration curve for chlorzoxazone in chloroform gave a linear working range of 0.027-2.3 microgram/ml (r = 0.9999) with the m... | 458,615 | [
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Isolation and identification of 3,3',5,5'-tetrabis(tert-butyl)stilbenequinone from polyethylene closures containing titanium dioxide and butylated hydroxytoluene. | A yellow compound was isolated from commercially available, discolored, polyethylene ophthalmic closures containing titanium dioxide and butylated hydroxytoluene (I). This compound was present at 7.46 ppm (w/w). It was identified by UV, IR, and mass spectra as 3,3',5,5'-tetrabis(tert-butyl)stilbenequinone (II), a dimer... | 458,616 | [
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Cellular pharmacology of 7(R)-O-methylnogarol: a new anticancer agent. | The cellular accumulation and disposition of 7(R)-O-methylnogarol (7-OMEN), a derivative of the anthracycline antibiotic, nogalamycin, were compared to those of daunorubicin. Although both drugs were avidly accumulated by cells, intracellular concentrations of 7-OMEN were 5 to 10 times those of daunorubicin. Lowered te... | 458,629 | [
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Ionic currents in response to membrane depolarization in an Aplysia neurone. | 1. Action potentials recorded in the soma of R15 neurones in the abdominal ganglia of Aplysia juliana were not suppressed by selective inhibition of either Na or Ca conductance alone. It was necessary to block both conductances to suppress action potentials. 2. Membrane currents generated by step depolarizations of the... | 458,642 | [
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Contraction time and voluntary discharge properties of individual short toe extensor motor units in man. | 1. The contraction time and the voluntary discharge properties of forty-five short toe extensor motor units were studied in man. 2. The contraction time of the individual motor unit was studied by using selective electrical nerve stimulation or by averaging the increase in force related to its electromyographic potenti... | 458,649 | [
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An investigation into the validity of subatmospheric pressure recordings from synovial fluid and their dependence on joint angle. | 1. Synovial fluid hydrostatic pressures were measured in normal knee (stifle) joints of anaesthetized rabbits using perforated cannulae. Pressures were subatmospheric in seventy out of seventy-two joints, with a mean value of -4.6 cm H2O (range 0 to -12 cm H2O) at joint angles of 120--150 degrees. 2. Similar values wer... | 458,691 | [
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Effects of true and inverted feedback on integrated occipital alpha. | Ambient illumination had no effect on baseline levels of alpha of 20 female university students who had their eyes closed, and significant increases from these levels were obtained through true but not inverted feedback procedures. These results indicate that alpha enhancement can be obtained in a manner that is not ex... | 458,747 | [
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Physiology and disease of the respiratory system in pregnancy. A review. | This review has attempted to describe the changes in respiratory physiology which occur during pregnancy and to use this knowledge to aid in the understanding of respiratory disease. Three forms of respiratory failure have been described and representative examples of each discussed. | 458,760 | [
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Gastrointestinal involvement in rheumatoid arthritis: a biopsy study. | Gastric, colonic and rectal biopsies were obtained from patients with rheumatoid arthritis. The histologic study demonstrated a greater incidence of pathological findings compared to normal subjects or in patients with gastrointestinal diseases. The histologic changes were characterized by partial or complete loss of s... | 458,789 | [
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Chronic lower leg ulceration in systemic lupus erythematosus. | Four patients with chronic recurrent deep lower leg ulcerations complicating systemic lupus erythematosus are reported. In each case, highly expressed systemic lupus erythematosus was evident and the ulcers were generally poorly responsive to therapeutic maneuvers and were severely debilitating. This lesion appears to ... | 458,792 | [
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Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. | A series of (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates has been prepared and screened for analgesic and antiinflammatory properties in mice and rats. The tabulated results reveal several 2-(4-substituted phenyl-1-piperazinyl)ethyl 2-(7- or 8-substituted 4-quinolinylamino)benzoates... | 458,805 | [
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Conductance noise of monazomycin-doped bilayer membranes. | The conductance noise of the monazomycin pore has been studied by autocorrelation analysis in multi-pore systems. The autocorrelation function could be described by a superposition of two single exponential functions of different time- and voltage-dependence. The slow voltage-dependent correlation time in the range of ... | 458,843 | [
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Distribution of potassium and chloride permeability over the surface and T-tubule membranes of mammalian skeletal muscle. | The distribution of K and Cl permeability, PK and PCl, over the surface and T-tubule membranes of red rat sternomastoid fibers has been determined. Membrane potential, Vm, was recorded with 3-M KCl-filled glass microelectrodes. Changes in Vm with changes in [K]o or [Cl]o were used to estimate PCl/PK in normal and detub... | 458,844 | [
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An emergency medical system approach to disaster planning. | The increasing prevalence of terrorist attacks and natural disasters has mandated that more emphasis be placed on emergency disaster planning. The report focuses on the 1976 Courthouse bombing in Boston, which generated 20 casualties. Ambulance response by Boston's Emergency Medical Service system was made in 2.5 minut... | 458,880 | [
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The role of communication aids in the rehabilitation of hearing impairment. | The primary emphasis in rehabilitating the hearing impaired has involved fitting a hearing aid. There are patients however, who can be helped by communication aids in addition to, or in place of hearing aids. Communication aids include any device, other than a conventional hearing aid, which assists the hearing impaire... | 458,909 | [
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Clinical experience with brain stem audiometry performed under general anesthesia. | Hearing tests were given to 22 difficult-to-test children using brain stem audiometry performed under general anesthesia. The effect of halothane and sodium thiopental on the brain stem response was assessed as well as the feasibility of using this technique with a difficult-to-test population. No effect on brain stem ... | 458,910 | [
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-0.105076,
-0.09871785,
0.02061827,
0.2276904,
-0.2985746,
-0.08009944,
0.1583448,
-0.3161539,
0.1736101,... |
Some aspects of therapy in the non-healing granulomas of Wegener and Stewart. | The non-healing granulomas of Wegener and Stewart (Wegener's granuloma and lethal midline granuloma) have been recognized since 1897. A mainstay of therapy has been the empirical application of treatments based upon theoretical or pathological assumption, and we are only slightly closer to classifying these diseases. B... | 458,913 | [
-0.2794547,
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0.02256973,
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0.1044821,
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0.2591354,
0.1383947,
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0.1308322,
... |
Zenker's diverticulum- carcinoma of the esophagus? | Malignant change may occur in a pharyngo-esophageal diverticulum and although it is rare, a small number of cases has been reported. A similar case is reported here to contribute to the awareness of the existence of such an entity. | 458,921 | [
-0.3244585,
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0.1604186,
0.07586271,
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0.1909394,
0.08358786,
-0.2116216,
... |
Posterior urethral stricture repair. | Experience with 54 operations for the membranous-prostatic urethral stricture is presented. There were 7 operations performed through pubectomy exposure, 6 Badenoch operations, 31 exteriorization 2-stage operations using a perineal-scrotal flap for the first stage and 10, 1-stage transperineal end-to-end anastomoses af... | 458,944 | [
-0.1479192,
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0.180551,
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0.1940445,
0.6159275,
-0.2030214,
... |
The use of estramustine and prednimustine versus prednimustine alone in advanced metastatic prostatic cancer patients who have received prior irradiation. | Estramustine has been shown previously to be an effective drug in the treatment of metastatic prostatic cancer, demonstrating significant objective and subjective responses in long-term non-randomized trials and in other randomized trials. In this study prednimustine alone has shown a minimal over-all objective respons... | 458,947 | [
-0.1485014,
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0.105147,
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0.077052... |
The benefits of evaluation of the patient with recurrent or multiple calcium stones. | Metabolic evaluation of patients with multiple or recurrent calcium stones has been fruitful. The great majority of cases has demonstrated abnormalities contributing to stone formation. Hypercalciuria on the basis of increased intestinal absorption of calcium was a common finding. The evaluation led to improved guide l... | 458,948 | [
-0.1032648,
0.1122614,
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0.0004801433,
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0.2249288,
0.1864696,
-0.09850... |
Enuresis: principles of management and result of treatment. | We studied 115 consecutive cases of primary enuresis. Excretory urography, urodynamic testing and endoscopy are needed only in children with enuresis and concomitant urinary infection. A detailed urologic history was the most important factor in deciding upon a treatment program. Children with diurnal and nocturnal enu... | 458,953 | [
-0.1295283,
0.1441179,
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0.2419729,
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0... |
Bilateral multilocular renal cysts with recurrence. | Multilocular renal cysts may occur bilaterally. A partial nephrectomy usually is curative but unroofing of the cyst may lead to recurrence. We suggest to delete the criterion of unilaterality and to base the diagnosis on histological features. The first case of bilateral multilocular renal cysts with unilateral recurre... | 458,957 | [
-0.06760389,
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0.2352557,
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0.2033438,
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... |
Neurogenic bladder and the tethered spinal cord syndrome. | We report 2 cases of the tethered spinal cord syndrome. Early clinical detection of this syndrome in children with bladder dysfunction should be followed by diagnostic myelography and immediate surgical release of the spinal cord. The pathophysiology of the syndrome is discussed. | 458,974 | [
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0.1552734,
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Gracilis muscle flap for closure of rectourethral fistula. | A gracilis muscle flap can be used to close a rectourethral fistula caused by operative trauma and radiation. The flap is rotated easily into the perineum, brings vascularized muscle to irradiated and/or traumatized tissue and is a mechanical barrier between the urethra and the rectum. | 458,977 | [
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0.02406972,
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-0.01673561... |
Lower extremity complications of the lithotomy position: prevention and management. | We describe 2 unusual and serious complications of the lithotomy position, anterior compartment syndrome and peroneal nerve palsy. The methods of management and prevention are discussed. | 458,981 | [
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0.08399033,
0.1111... |
Heterozygous cystinuria and calcium oxalate urolithiasis. | Many variables are known to be associated with the formation of calcium oxalate urolithiasis but none is essential for the initiation or growth of stones. It is likely that the predisposition to stone formation is related to multiple factors. We herein describe still another metabolic state that seems to predispose to ... | 458,988 | [
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0.3108261,
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... |
Surgical management of massive neurogenic hydronephrosis. | Permanent urinary diversion has been the standard recommended treatment of massive dilatation of the upper tracts in the child with neurogenic vesical dysfunction. Reimplantation of relatively normal caliber ureters into neurogenic bladders has been shown to be effective. However, attempts to save urinary diversion in ... | 458,992 | [
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0.2928307,
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0.0541263,
... |
Urethral and bladder responses to anal electrical stimulation. | Urethral and bladder responses to anal electrical stimulation were evaluated by cystometry and urethral pressure profile measurements in 55 patients with different urethral-bladder dysfunctions. In 50 per cent of the patients examined the electrical stimulation caused normal reciprocal response, that is bladder inhibit... | 459,014 | [
-0.01823634,
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0.2995757,
... |
The value of the negative radionuclide scrotal scan in the management of the acutely inflamed scrotum in children. | Torsion of the testis remains a clinical diagnosis and confirmatory testing is not required when the classic signs and symptoms are present. Conflicting laboratory data or adjunctive diagnostic studies should not dissuade the surgeon from exploration when the clinical index of suspicion is high. In those patients havin... | 459,018 | [
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0... |
Constrictive albuginitis: report of 3 cases. | Three sterile patients with constrictive albuginitis are described. The most common presenting symptom is a long duration of scrotal pain and the testicles are small and firm. Testicular biopsy is characterized by peritubular fibrosis. Spermatogenesis may be complete but the cells are degenerated. The condition is bila... | 459,031 | [
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0.2988839,
0.2368279,
-0.3059891,
... |
Onion, garlic, and experimental atherosclerosis. | Forty-two healthy male albino rabbits weighing around 1 Kg were divided into 4 groups. Group I (8)- fed on normal stock diet, Group II (8)- fed on stock diet plus cholesterol (0.5 gm in 5 ml of olive oil). Group III (15)- received stock diet plus cholesterol plus garlic (0.25 gm) juice. Group IV (11)- received stock di... | 459,102 | [
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0.4051098,
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0.3976244,
-0.1839514,
... |
Diuretic action of metolazone in dogs. | Metolazone, the sulfonamide diuretic was investigated to determine the sites of action. We used a radioactive microsphere, clearance and stop-flow method in anesthetized dogs. Urine flow and urinary excretion of sodium and potassium were increased at 5--60 min when metolazone was given intravenously at doses of 0.2--5.... | 459,149 | [
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0.2705847,
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0.09107071,
-0.... |
[Primary hyperparathyroidism--bone turnover and osteitis fibrosa assessed by x-ray (author's transl)]. | 1. In primary hyperparathyroidism an increased bone turnover is seen, accompanied by osteitis fibrosa (= fibroosteoclasia, FO) in severe forms of the disease. Both types of bone reaction may be detected by microradioscopy X-rays of the hand, extensive striation of metacarpal cortical bone indicating increased bone turn... | 459,367 | [
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Activity of procollagen-prolyl-hydroxylase and N-acetyl-beta-glucosaminidase in liver biopsies from patients with chronic liver diseases. | In 5 mg of liver tissue obtained by needle biopsy from patients with chronic liver diseases, activity of both Procollagen-prolyl-hydroxylase and N-Acetyl-beta-glucosaminidase was measured. The activity of both enzymes increased due to the activity of fibrosis, but prolylhydroxylase increased more. The relation of these... | 459,373 | [
-0.251219,
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... |
[Ultrastructure of the lymph nodes of dogs under prolonged external gamma irradiation]. | The purpose of the present investigation was electron microscopy study of lymph nodes of dogs exposed to chronic gamma-irradiation during 6 years (with a total dose of 125 rad/year). The exposure induced changes in the cell composition of the paracortical regions due to a decrease of the count of small lymphocytes and ... | 459,403 | [
-0.09850475,
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0.4054317,
0.09241053,
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0.3992883,
0.1339146... |
Cardiovascular function in anesthetized miniature swine. | Miniature swine anesthetized with pentobarbital were studied with respect to their cardiovascular function under control conditions and in response to catecholamines, baroreceptor inhibition, bilateral vagotomy and vagal nerve stimulation. Measurements included aortic pressure, heart rate, intraventricular pressure and... | 459,414 | [
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0.2002124,
0.0072222... |
Multiple biopsies of guinea pig mammary glands during pregnancy and lactation. | Mammary gland biopsies were obtained from 39 guinea pigs during late pregnancy, lactation and weaning. Up to eight samples, each weighing 60--200 mg, were taken from each animal in two independent studies. No mortalities resulted, and no interference with lactation or suckling was observed. | 459,418 | [
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... |
The use of Reuber hepatoma cells for the study of a lipopolysaccharide-induced macrophage factor: glucocorticoid-antagonizing factor. | Endotoxin-stimulated glucocorticoid-antagonizing factor (GAF) was assayed by its specific inhibition of hydrocortisone-induced synthesis of phosphoenolpyruvate carboxykinase. Defined induction of phosphoenolpyruvate carboxykinase synthesis in hydrocortisone-treated rat hepatoma cells permitted reliable quantitation of ... | 459,433 | [
-0.01914362,
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0.5046373,
0.1163326,
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-0.1697972,
... |
Analysis of transmembrane dynamics of cholera toxin using photoreactive probes. | Using sodium dodecyl sulfate--polyacrylamide gel electrophoresis and autoradiography, we have shown that 125I-labeled cholera toxin binds to Newcastle disease virus. Pretreatment of Newcastle disease virus with "cold" cholera toxin (at 37 degrees C for 30 minutes) inhibits the binding of 125I-labeled toxin in a subsequ... | 459,511 | [
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-0.08578671,
0.3909972,
0.2859545,
-0.273866... |
Five-day continuous infusion of 5-fluorouracil for advanced colorectal, gastric, and pancreatic adenocarcinoma. | In a retrospective study, 58 patients with advanced colorectal carcinoma received one or more 5-day infusions of 5-FU at 20 mg/kg per 24 hours followed by weekly IV 5-FU at 15 mg/kg. In 36 patients who received the infusion as first treatment (Group A), the response rate was 23% with a median duration of response of 8.... | 459,516 | [
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0.1445078,
0.306438,
0.3464795,
0.3477802,
0.2343801,
-0.11... |
Reductive surgery of unresectable lung cancer: a case report. | The only effective therapy for non-small-cell lung cancers has been surgical resection. In the present study a patient with unresectable adenocarcinoma of the lung was treated by chemoimmunotherapy and surgery, and has been doing well for 19 months following surgery. The case is presented as an example of treatment of ... | 459,518 | [
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0.1047245,
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0.05965468,
0.09857205,
0.0988797... |
Specific afterload reduction with parenteral hydralazine following cardiac surgery. | In a group of seven patients who had had cardiac operations, intravenous (IV) hydralazine was used to provide afterload reduction in situations of severe left ventricular dysfunction. Despite fluid loading, inotropic support with dopamine, and afterload reduction with sodium nitroprusside, the patients had persistent s... | 459,526 | [
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0.02351831,
0.06017796,
... |
St. Jude Medical cardiac valve prosthesis: in vitro studies. | The St. Jude Medical cardiac valve prosthesis is an all-pyrolitic carbon, bileaflet, low profile, central flow device. Prior to clinical use on intensive program of in vitro and in vivo testing was undertaken. Simulated radiographic studies determined that the tungsten impregnation needed to make the valve leaflets rad... | 459,535 | [
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0.02335971,
0.01862257,
0.275268,
0.28077,
0.01... |
[Incidence of painful menstruation in Macedonia]. | A total of 6930 pupils born between 1955 and 1966 were inquired by a questionnaire. It has been found that painful menstruation was present in 2786 pupils (40.20%) Along with a high percentage of painful menstruations, a high percentage of menstrual disturbances was recorded in younger pupils. Certain differences were ... | 459,541 | [
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Total joint arthroplasty. Introduction to the upper extremity. | Total joint replacement in the upper extremity has developed in step with that of the lower extremity. The indications for treatment, the place of total joint arthroplasty in contrast to other forms of arthroplasty, and the criteria for patient selection have recently been classified. A number of problem areas are unde... | 459,560 | [
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Usher's syndrome with unusual otologic manifestations. | Usher's syndrome is characterized by a congenital hearing loss and retinitis pigmentosa. Ocular symptoms and signs are usually established at adolescence, and the hearing loss, the onset of which is at a young age, generally remains stable. The following case is of interest, therefore, because the hearing loss that had... | 459,566 | [
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A new intermediate dental outcome measure: amalgam replacement rate. | The length of time amalgam restorations last before replacement was investigated for use as an intermediate outcome measure in utilization review and quality assurance studies. Based on record data from 37 general dental practices, a determination was made of the average percentage of two- or three-surface amalgams rec... | 459,578 | [
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[Epidemiologic data on bronchogenic carcinoma (author's transl)]. | The Bronchogenic Carcinoma Co-operative Group analyzed the epidemiologic data of 240 cases of bronchogenic carcinoma in a prospective study. When risk factors (exposure to potencial pathogenic substances) were studied, a relationship was noted between the incidence at an early age and the presence of nondifferentiated ... | 459,602 | [
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[Surgery of bronchus carcinoma (author's transl)]. | The results of surgery for bronchial carcinoma can be improved by further stressing of early diagnosis, by operative methods adapted to oncological needs and assessment of techniques which increase operability as well as by adequate and general additional therapy. Based on our material of 8,423 patients of which 2,773 ... | 459,646 | [
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... |
[Sarcoidosis of the larynx (author's transl)]. | The isolated case of sarcoidosis of the larynx is very rare. We are referred to a case of histologically confirmed by the kweim-test of sarcoidosis of the false vocal cord. The problems of the case are discussed. | 459,652 | [
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Malignant melanoma of the scalp. | Malignant melanoma of the scalp has a significantly worse prognosis than cutaneous melanoma arising in other head and neck sites. In this series, 125 patients were treated for Stage I invasive melanoma of the scalp and followed 3 to 19 years. Survival rates for these patients were calculated on the basis of several fac... | 459,653 | [
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Laryngotracheal trauma: observations on its pathogenesis and its prevention following prolonged orotracheal intubation in the adult. | The authors have clinically examined the larynges of 117 patients who were successfully extubated in a Respiratory Care Unit, and have examined the larynges at autopsy from an additional 68 patients who failed to survive in the same Respiratory Care Unit. Based on these observations, our understanding of the pathogenes... | 459,664 | [
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Biliary cholesterol absorption in normal and L-thyroxin-fed rats. | Infusion of bile containing labeled cholesterol into bile fistula rats has permitted an in vivo study of the movements and of the absorption of biliary cholesterol in the digestive tract. The specific activities of cholesterol were similar in the micelles and the sediment of the luminal content after a 6 hr infusion, i... | 459,708 | [
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Glycolysis-dependent antimetabolities: possible improvement in antineoplastic selectivity. | The increased rate of glycolysis in neoplastic cells may be used to design tentatively antimetabolites whose detoxification would be faster in normal cells. Pyruvo-substituted nucleotides are examined in this respect and their expected differential metabolism outlined. | 459,963 | [
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The influence of ambient ozone on the incidence of bone fractures especially among the elderly. | Elevated levels of breatheable ozone will reduce the amount of UV radiation in the range of 280-305 nm reaching the surface of earth. This range of UV converts the provitamin 7-dehydrocholesterol to vitamin D, within the human. Since most typical diets contain low levels of vitamin D, the role of UV related vitamin D s... | 459,973 | [
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Toward establishing scientific credibility in acupuncture research. | While the effectiveness of acupuncture has been established clinically, research methods and tools which are basic for establishing objective scientific credibility in medicine have been a problem in acupuncture research. Research methods developed in other areas and reported in the literature are presented which could... | 459,975 | [
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Psychosomatic disease and acupuncture. | The medical philosophy implied by a "mind-body unity" hypothesis is outlined and the type of therapy appropriate to the stage of development of disease is discussed; special reference is made to the place of acupuncture within a modern medical program. Starting from the premise that mind is the primary causal force det... | 459,976 | [
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Hypercalcaemia in adult hospital population: comparison of inpatients of 1966 with those of 1976. | During 1976, inpatients with hypercalcaemia at The Royal Melbourne Hospital were identified from the worksheets of the Department of Biochemistry and compared with those discovered in a similar study in 1966. In 1966, the estimation of plasma calcium level had to be ordered specifically, whereas in 1976, for technical ... | 459,998 | [
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Premature rupture of the membranes. | In a consecutive series of 93 patients with premature rupture of the membranes at 20 to 34 weeks of gestation, the perinatal mortality was 23.7%. One-quater of the deaths were due to lethal congenital abnormalities, 18% were due to intrauterine infection, and 36% resulted from severe respiratory distress syndrome (RDS)... | 460,000 | [
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[Rapid atrial stimulation in the treatment of atrial flutter (author's transl)]. | Study on 35 patients suffering from atrial flutter, in which rapid atrial stimulation was made 40 times. Stimulation-catheters were introduced only by control of the intracardiac ecg without x-ray control. Sinus rhythm was restored in 31 cases, in 17 cases intermediate atrial fibrillation of varying length of duration.... | 460,031 | [
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Synthesis of phosphatidly-dCMP in permeabilized normal human lymphocytes. | When peripheral lymphocytes stimulated with phytohemagglutinin were permeabilized in vitro, (3H) dCTP acted as a precursor for DNA synthesis, but the formation of a compound soluble in organic solvents could also be demonstrated. The structure of the latter compound was studied analyzing the products formed after alkal... | 460,175 | [
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Red-cell-membrane polypeptide aggregates in glucose-6-phosphate dehydrogenase mutants with chronic hemolytic disease. A clue to the mechanism of hemolysis. | Red-cell membranes from patients with glucose-6-phosphate dehydrogenase deficiency were studied with polyacrylamide gel electrophoresis and gel filtration chromatography in sodium dodecyl sulfate. Membranes from each of five such patients who also had chronic hemolytic disease contained polypeptide aggregates within tw... | 460,305 | [
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Quinidine-digoxin interaction: Pharmacokinetics, underlying mechanism and clinical implications. | Administration of quinidine with digoxin increased serum digoxin concentrations in 79 patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the addition of quinidine to digoxin therapy resulted in a mean 2.5-fold increase (from 0.98 +/- 0.37 to 2.47 +/- 0.71 ng per milliliter, mean +/- ... | 460,341 | [
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... |
Population biology of infectious diseases: Part I. | If the host population is taken to be a dynamic variable (rather than constant, as conventionally assumed), a wider understanding of the population biology of infectious diseases emerges. In this first part of a two-part article, mathematical models are developed, shown to fit data from laboratory experiments, and used... | 460,412 | [
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Cranioplasty with pre-formed methyl methacrylate onlay plates. | The available manufactured plates for cranioplasty of large skull defects are not always satisfactory. Recently we have used preformed methyl methacrylate plates, in combination with Proplast. This plate prepared adjusted and sterilized before the operation is both cosmetically and mechanically satisfactory. | 460,516 | [
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[Cystoadenocarcinoma of the pancreas]. | A case of papilliferous cystadenocarcinoma of the body and tail of the pancreas marked by unusually slow progresion is presented. It is pointed out that total resection, of the tumour is always necessary. This is also true of cystadenoma, which has a tendency to become malignant. | 460,623 | [
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[Malignant histiocytosis. Histiocytic medullary reticulosis]. | The Authors report a case of malignant histiocytosis apparently localized only in the spleen. The diagnosis of the disease, characterized at the onset by moderate leukopenia and thrombocytopenia, was made possible by the histopathologic examination of the spleen following splenectomy. The disease shows a chronic course... | 460,652 | [
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Topographical distribution of substance P in the cat substantia nigra. | The substance P (SP) content in cat substantia nigra (SN) was estimated by radioimmunoassay in microdiscs punched on successive frontal sections. Only slight differences were seen in the regional distribution of SP within the SN. The highest content was found in the pars reticulata (20.7 pmol/mg protein) which was two ... | 460,695 | [
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A non-adrenergic nerve ending containing small granular vesicles in the guinea-pig gut. | Two distinct types of small granular vesicle(SGV)-containing nerve ending are described in the gastrointestinal tract of the guinea-pig. One of these types of ending accumulates 5- and 6-hydroxydopamine (OHDA) and is therefore adrenergic. The other type remains unchanged after in vivo exposure to these drugs. The wides... | 460,705 | [
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The comparative effectiveness of the "brown and blue reactions" for tracing neuronal processes of cells injected intracellularly with horseradish peroxidase. | The comparative advantages and disadvantages of diaminobenzidine (DAB) and benzidine di--HCl (BDHC) procedures for tracing processes of cells injected intracellularly with horseradish peroxidase (HRP) have been studied. The DAB reaction gives a good definition of membranes and appears more suitable for visualizing the ... | 460,707 | [
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... |
In vitro radioisotope precursor incorporation into ribonucleic acid and protein in dystrophic mouse gastrocnemius muscle (C57 BL/6J dy2J/dy2J). | An in vitro tissue slice technique has been developed and used to compare radioisotope precurosr incorporation into RNA and protein in normal and dystrophic mouse gastrophic muscle. Significant differences are observed with both RNA and protein when incorporation is measured on a fresh weight of muscle basis. Specific ... | 460,716 | [
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-0.1767657,
... |
On the presence of extraneuronal catecholamine in the iris of the rat: a scanning microfluorimetric study. | Formaldehyde-induced fluorescence (FIF) of noradrenalin (NA) was studied in histochemical preparations of the rat iris. With the aid of a two-dimensional microfluorimetric scanning method, quantitative information was obtained from neuronal and non-neuronal elements selectively. Spectral analysis and fluorimetric studi... | 460,717 | [
-0.1565558,
0.1096056,
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0.2153573,
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0.09164979,
0.2947618,
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0.1034719,
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0.02032246,
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0.05252555,
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0.1583161,
0.2496909,
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0.1550748,
... |
Positive rubella titers in pregnancy: a question of validity. | A review of 25 patients with more than 1 rubella titer by hemagglutination-inhibition testing revealed 3 patients with high positive titers that were reported to be negative in subsequent pregnancies. None of the patients had received the rubella vaccine. Because the sensitivity and reliability of hemagglutination-inhi... | 460,760 | [
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0.2740475,
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0.1100765,
-0.1530126,
0.1058118,
0.1040464,
-0.0343514,
0.0543549... |
Bone scintigrams: their clinical usefulness in patients with breast carcinoma. | A comparison of bone scintigrams and roentgenographic skeletal surveys, obtained on 170 patients with breast carcinoma, was made to evaluate the diagnostic efficacy of these techniques in detecting metastatic bone lesions. The bone scans were abnormal in 81 patients, while the roentgenograms were abnormal in only 51. I... | 460,790 | [
0.09023559,
0.1681951,
0.04383811,
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0.187315,
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0.001452469,
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0.225904,
0.4061341,
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0.3718172,
0.1410517,
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... |
[Cell cycles in the early embryogenesis of the peled]. | The dynamics of cell cycles in early embryogenesis of the peled has been studied using various methofs: determination of mitotic and mitotic phase index, of cell doubling time and of coefficient of asynchrony. The desynchronization of divisions begins at the V division after the longitudinal furrow has passed and is co... | 460,794 | [
-0.1344888,
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0.08055636,
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0.01264997,
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0.323702,
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0.1388263,
0.6854019,
0.2347544,
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0.0... |
Vitrectomy in experimental endophthalmitis: Part II--Bacterial endophthalmitis. | Three methods of treatment for Staphylococcus aureus endophthalmitis were compared: subconjunctival injection with intramuscular gentamicin, intravitreal injection with intramuscular gentamicin, and vitrectomy using infusion solution containing gentamicin along with intramuscular gentamicin. Subconjunctival injection w... | 460,811 | [
-0.1087455,
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0.1496826,
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0.2718985,
0.2076325,
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0.1866481,
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0.08585601,
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-0.06655905,
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0.09089603,
0.3728... |
Composition and evaluation of the efficacy of Staphylococcus aureus vaccine. | An alum-precipitated Staphylococcus aureus vaccine, composed of a formalin-inactivated whole culture of a strain which produces Smith surface antigen and combined with the whole culture of a highly toxigenic strain, was found to afford a good immunity to staphylococcal skin infection in rabbits. Three injections of the... | 460,818 | [
0.06935543,
0.1506679,
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0.08284476,
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0.2007391,
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0.04006672,
0.04890796,
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0.04279236,
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0.07043894,
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0.1429728,
0.4888575,
0.2443122,
-0.1989013,
... |
Aerospora of an Eragrostis curvula pasture in South Africa. | A qualitative and quantitative survey was made of the aerospora above an Eragrostis curvula (Schrad.) Nees pasture. The pasture, which lay adjacent to a field of Panicum coloratum L. where an outbread of ovine photosensitivity had occurred, was not grazed during the survey. A Burkard volumetric spore trap was used to s... | 460,819 | [
-0.2143728,
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0.02204132,
0.0001333688,
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0.3742643,
0.1527187,
0.2734574,
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0.1316442,
0.1433662,
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0.3220587,
0.3603779,
0.1433506,
-... |
The effect of high tibial osteotomy on osteoarthritis of the knee. An arthroscopic study of 54 knee joints. | 1. Arthroscopic findings in repair of articular surfaces and the operation's effect on healthy components made it clear that the ideal correction method is to align the mechanical axis to pass through a point 30 to 40 per cent lateral to the midpoint. 2. If ideal correction was obtained, it was observed by arthroscopy ... | 460,834 | [
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0.2806662,
0.1843937,
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0.1140978,
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-0.2793079,
0.1853792,
0.06668928,
0.0023314... |
The initial evaluation of the patient with multiple injuries. | The management of trauma patients requires organization and the cooperation of trained health personnel, beginning at the site of injury and continuing until the patient is discharged from the hospital. Treatment guidelines and priorities must be well outlined in advance to provide optimal care and minimize delay prior... | 460,873 | [
-0.2491792,
0.2225519,
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0.1385181,
0.08538352,
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-0.08618908,
-0.06337712,
-0.2743728,
0.05672476,
-0.04620431,
-0.07503868,
0... |
The initial evaluation in maxillofacial trauma. | Evaluation in maxillofacial trauma is primarily an extension of the art of the physical examination, with inspection, palpation, and evaluation of loss of normal function as the primary requisites. X-ray evaluation is critical, and best results are usually obtained by taking films as soon following the injury as possib... | 460,876 | [
-0.08534447,
0.1505246,
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0.001719091,
-0.2959688,
0.0397829,
0.2315762,
-0.1845815,
0.1128461,
-0.05601952,
-0.13... |
Management of acute ear infections. | The differential diagnosis between the usual acute otitis externa and acute suppurative otitis media is presented. Other important and sometimes frequently seen entities that present as infections in the ear are also discussed. It is emphasized that a patient complaining of ear pain with normal findings on examination ... | 460,883 | [
-0.2591759,
-0.1291506,
-0.2452926,
-0.243618,
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0.3053993,
-0.3714485,
-0.05219761,
0... |
[Experiences with autogenic training groups (author's transl)]. | According to I. H. Schultz, "Autogenic Training" has helped many children with psychosomatic symptoms. The children's symptoms were obviously influenced by disturbed family-situations and so we invited both children and parents to the "Autogenic Training". The treatment was carried out in two parallel groups, 6 childre... | 460,916 | [
-0.2614374,
0.1552377,
-0.05370626,
0.1073359,
0.3727542,
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0.1224134,
0.1290075,
0.2897833,
0.155238,
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0.1412047,
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0.04238637,
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0.2137765,
0.1971633,
-0.08480334,
-0.2013141,
-0.... |
Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. | (1) Sixty-eight convergent dorsal horn neurones have been recorded at the lumbar level in anaesthetized intact rats. All cells received prominent A alpha and C fibre afferents and correspondingly could be activated by high and low threshold stimuli applied to the peripheral excitatory receptive field. (2) The activity ... | 460,935 | [
0.1479133,
-0.004524856,
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0.08732025,
0.2700739,
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-0.1421488,
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0.1646073,
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-0.2144535,
0.114316,
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0.2732307,
-0.05735679,
-0.1515088,
-0.08366183,
0.2808715,
0.18014... |
Brain evoked potentials are functional correlates of induced pain in man. | Electrical potentials evoked by 5 intensities of painful dental stimulation were recorded at the scalp. During testing, volunteers indicated subjective painfulness by verbal pain ratings and visual analogue scales. Evoked potentials (EPs) to each intensity, observed between 50 and 400 msec, were characterized by 4 wave... | 460,937 | [
0.07149026,
0.1713089,
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-0.4253302,
-0.2891021,
0.0007602689,
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-0.3621162,
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-0.513567,
0.0727093,
0.05465044,
0.1442344,
0.1179951,
0.1008214,
0.1624691,
... |
Oestrogen receptor protein in breast cancer: a local study. | An assay using charcoal adsorption to separate bound oestradiol from free oestradiol has been set up to study the oestrogen receptor (ER) status of patients with all stages of breast carcinoma. The specificity of the oestradiol uptake was checked by competitive pre-incubation with anti-oestrogens and non radioactive oe... | 460,944 | [
-0.01231675,
0.07058828,
0.04001124,
-0.1100411,
-0.2666965,
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-0.2112098,
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0.3116158,
-0.0656001,
0.4698671,
0.05165454,
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-0.5487172,
-0.3297496,
-0.1743041,
0.1694853,
-0.008441539,
0.00158828,
0.3145511,
0.2896619,
-0.16703... |
Report on blind subjects' tactile and auditory recognition for environmental stimuli. | In two related experiments on recognition-on touch and audition-accuracy rates were obtained from congenitally blind subjects and compared with those for normally sighted subjects. In Exp. 1, 5 blind subjects inspected, i.e., handled, 150 common objects and were tested after a delay of 7 days. In Exp. 2, 9 blind subjec... | 461,034 | [
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0.1050325,
0.2010685,
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0.2678493,
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0.09053005,
0.4376692,
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-0.8076608,
0.07758556,
-0.420898,
-0.1371556,
0.102951,
0.4247639,
-0.02110555,
-... |
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