title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Treatment of women in childbirth: implications for family beginnings. | This paper presents an ethnographic analysis of a woman's interaction with staff members during the early stage of labor, focusing on the factors that shape the childbirth experience. The observational data were gathered in several hospitals as part of a study of the medical context of childbearing. The paper presents ... | 474,845 | [
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Evaluation of the relationship of sodium in drinking water and toxemia of pregnancy. | This study is a retrospective case comparison analysis of the relationship of water-borne Na+ and toxemia of pregnancy as a part of a continuous investigation at our facility on the role of various water constituents in human chronic disease. Five hundred thirty-seven toxemic pregnant women delivered at Jefferson Davis... | 474,848 | [
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The saphenous nerve: its course and importance in medial arthrotomy. | Both lower extremities of 10 cadavers (20 specimens) were dissected to delineate the course of the saphenous nerve and its two major divisions (sartorial and infrapatellar branches). The course of the saphenous nerve followed the standard text description, except at the point in the sartorius muscle where the infrapate... | 474,860 | [
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Neurogenesis in the basal forebrain of the Chinese hamster (Cricetulus griseus). I. Time of neuron origin. | The time of neuron origin has been determined in the basal ganglia and related basal forebrain structures of the Chinese hamster with the aid of 3H-thymidine autoradiography. Large-celled structures like the globus pallidus, nucleus of the horizontal limb of the diagonal band of Broca as well as large cells in the rost... | 475,002 | [
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Mandibular growth retardation in corticosteroid-treated juvenile mice. | Juvenile mice were treated for up to eight weeks with weekly doses of a synthetic analogue of cortisol:triamcinolone hexacetonide. The mandibular condylar cartilage was studied histologically and histochemically at regular intervals. Morphometric measurements were performed along the mandibular posterior vertical dimen... | 475,004 | [
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Morphological study of the desert heteromyid kidney with emphasis on the genus Perognathus. | The renal morphology of three species of desert dwelling Perognathus rodents were compared to Dipodomys and two species of sympatric cricetid rodents. Perognathus has a highly adapted unipolar kidney capable of urine concentration up to 7,500 mOsm/KgH2O. Two major modifications were observed in these kidneys. (1) There... | 475,010 | [
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Mortality experience among anesthesiologists, 1954-1976. | To determine whether anesthesiologists, because of prolonged exposure to halothane or other inhalational anesthetics, might have higher death rates from all causes, from cancer, and from hepatic or renal disease than other physicians, the mortality rates of male and female members of the American Society of Anesthesiol... | 475,020 | [
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Neonatal IgE values in the black population. | Ninety-three cord blood samples from black neonates were evaluted for the total IgE level using the PRIST method. The results reveal values comparable to the IgE levels in other racial groups, suggesting that the influence of racial differences was not obvious at this stage. | 475,063 | [
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Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. | Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles. Four dosages of acetazolamide and methazolamide and three dosages of dichlorphenamide and ethoxzolamide were evaluated. The extent of ocular hypotony aft... | 475,084 | [
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Serum proteins of normal goats and goats with caseous lymphadenitis. | Values for total serum proteins and relative percentages of albumin, alpha 1-globulin, alpha 2-globulin, beta-globulin, and gamma-globulin were determined for the goat. These normal values were compared with those obtained for goats infected with Corynebacterium pseudotuberculosis. Goats chronically infected with C pse... | 475,093 | [
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Epizootiologic features of canine hydrocephalus. | In a retrospective study of hydrocephalus (of congenital origin) diagnosed in 564 dogs, 11 breeds (including 8 "toy" breeds) were identified as being a significantly high risk. An inverse relationship between risk and body size was detected. The smaller the dam at maturity, either in height at the shoulder or body weig... | 475,097 | [
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Complement activity and conglutinin activity in stored bovine sera. | Complement activity and conglutinin activity were measured in bovine sera stored under four conditions: phenolized (3 C), lyophilized (3 C), frozen (-23 C), and frozen (-57 C). The complement activity was lost after 12 weeks in phenol (3 C). The other three conditions, ranked in order of increasing effectiveness, are l... | 475,098 | [
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Regulation of bovine labor with a long-acting carba-analog of oxytocin: a preliminary report. | The long-acting oxytocin (OT) analog 1-desamino-1-monocarba-E12-Tyr(OMe)]-OT(dCOMOT) was given IV to 13 pregnant cows near to term, but not in actual labor. The animals were para 1 to 5. Of these cows, four were treated with 20 mg of dexamethoasone 48 hours before the peptide was injected; the remaining nine animals we... | 475,100 | [
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Hemodynamic effects of unilateral segmented lumbar epidural analgesia in cattle. | Hemodynamic measurements, arterial and mixed venous blood gas tensions, and pH were determined in 12 adult cows (mean weight 538 kg) following the injection of 8 ml of 5% procaine between the first and the second lumber vertebra into the epidural space. Comparison of base-line data with obtained during unilateral segme... | 475,109 | [
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Pathophysiologic response of the juxtaglomerular apparatus to dietary sodium restriction in the dog. | Pathophysiologic changes in the juxtaglomerular apparatus (JGA) of the dog were induced by 10 days of dietary sodium restriction (less than 1 mEq of Na+/day). Plasma renin activity increased 12-fold and plasma aldosterone values increased 60-fold, whereas urinary sodium excretion decreased precipitously. Urinary potass... | 475,132 | [
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Thyroid gland and arterial lesions of Beagles with familial hypothyroidism and hyperlipoproteinemia. | Primary hypothyroidism with marked hyperlipoproteinemia and modest to severe atherosclerosis was described in a family of Beagles. The disease was familial and probably hereditary, but the mode of inheritance was unknown. Signs of the disease occurred as early as 1.5 years of age and as late as 5 years of age. The onse... | 475,133 | [
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Metronidazole in the treatment of anaerobic infections. | Using metronidazole in oral dosages of 1.5 to 2 g daily, we treated 13 adults who had anaerobic pleuropulmonary infections, including 11 with lung abscess, one with necrotizing pneumonia, and one with thoracic empyema. Five patients (four with lung abscess and one with necrotizing pneumonia) were cured. The lung absces... | 475,154 | [
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[Foot lesions in non-insulin-dependent diabetes. A report on 25 cases (author's transl)]. | Diabetic lesions in 25 patients with maturity-onset non-insulin-dependent diabetes, but with neuropathy and even other complications in spite of previous treatment, were studied. Distribution according to the duration of the diabetes and the age of the patients was comparable to that seen in insulin-dependent diabetes.... | 475,208 | [
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Perithecial ultrastructure and formation of ascospores of Ceratocystis stenoceras (Robak) C. Moreau. | Fine details of perithecial morphology and aspects of ascospore formation of Ceratocystis stenoceras (Robak) C. Moreau are shown in electron micrographs of ultrathin sections. The envelope of the perithecial body proper consisted of two zones of cells which differed morphologically one from another. Loose aggregates of... | 475,217 | [
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[An assessment of caustic oesophageal burns in the child (author's transl)]. | 68 patients who might have had a caustic oesophageal burn were observed in the E.N.T. department of Enfants Malades Hospital between 1973 and 1977. We describe the causes, the age, the character of the burns analysed after systematic oesophagoscopy, and treatment. The results are studied taking into account the depth o... | 475,233 | [
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Cholesteatoma of the frontal and ethmoid areas. | Cholesteatomas of the frontoethmoid region must always be considered in the differential diagnosis of a mass in the frontoethmoid region. A painless, slow-growing mass, often accompanied by proptosis and diplopia, but without history of trauma or infection, should make one suspect of this pathologic entity. Although h... | 475,248 | [
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Restenosis of the mitral valve. | It is suggested that restenosis is inevitable after mitral valvotomy and that only the time taken for it to occur is variable. The major factor affecting the lapse of time between operations is the extent of the original valvotomy. Calification of the valve is less important, and coincident mitral incompetence and the ... | 475,268 | [
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Liver hilus dearterialization. A histological and electron microscopical study in the dog. | Liver histological and electron microscopical changes were studied in six dogs after liver hilus dearterialization and in two dogs after sham operation. All specimens were taken in vivo. In light microscopy a marked dilatation of the sinusoids was noted 90 minutes after dearterialization. After 24 hours it was even mor... | 475,301 | [
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[Modifications of the accessory glands of male genital tract of intact and castrated rats after sulpiride treatment (author's transl)]. | Sulpiride or Dogmatil (Delagrange, Paris) was injected to male rats at the rate of 40 mg/day for either 10 or 20 days. Ponderal fluctuations of the accessory organs followed by a quantitative analysis of fructose and of serum acid phosphatases issued from testis epididymis and prostates (PAP) were studied. The coagulat... | 475,305 | [
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[Metabolism of bone in culture (author's transl)]. | A method for studying in vitro bone matrix resorption by the use of 35S injection was investigated. Various hormones were tested and their effects on 35S and 45Ca metabolism were compared. | 475,312 | [
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Relationship between aminoglycoside-induced nephrotoxicity and auditory toxicity. | We have reviewed our data from 391 patients entered into three prospective, double-blind studies of aminoglycosides and evaluated 127 cases to determine whether aminoglycoside-induced auditory toxicity and nephrotoxicity are independent events. The cases selected for evaluation included all patients treated for greater... | 475,363 | [
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Acute infantile thrombocytosis and vitamin K deficiency associated with intracranial haemorrhage. | A 5-week-old breast-fed girl presented unconscious and convulsing with heavily blood-stained CSF under increased pressure. This was associated with oozing from venepuncture sites, a grossly prolonged prothrombin time, and a raised platelet count. The prothrombin time became normal 18 hours after she had been given pare... | 475,433 | [
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Premature menarche without other evidence of precocious puberty. | We describe 4 young girls with recurrent vaginal bleeding in the absence of other signs of precocious sexual development. Investigation showed low oestrogen levels in 2 of them, and basal gonadotrophins were in the upper part of the prepubertal range. We believe that the isolated early menstruation in these patients wa... | 475,434 | [
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0.4400557,
0.02251738,
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Elevated sodium levels in the public drinking water as a contributor to elevated blood pressure levels in the community. | Further statistical analyses of previously reported preliminary data upheld results showing elevated levels of sodium in drinking water may exert an adverse health effect on normal, healthy persons. High school sophomores residing in a community with elevated levels of sodium in the drinking water (107 mg/l) exhibited ... | 475,459 | [
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Augmentation of myocardial ischemia by low level carbon monoxide exposure in dogs. | This study was conducted to determine whether low level exposure to carbon monoxide would increase myocardial ischemia associated with acute myocardial infarction. An hour after coronary artery ligation, eleven anesthetized dogs underwent five sequential respiratory exposures to 5,000 ppm carbon monoxide, producing mea... | 475,472 | [
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[The system of complement in active rheumatic fever]. | Pathogenesis of inflammation in acute rheumatic fever is still unknown. There is humoral immune response against streptococcal products and streptococcal infection plays a role in etiopathogenesis. When inflammation is due to humoral immune mechanisms, the serum Complement system is the most important mediator. We stud... | 475,494 | [
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[Arteriovenous fistula and rheumatic cardiopathy]. | A case of pulmonary arteriovenous fistula associated with rheumatic mitral heart disease is presented. We have reviewed the literature and no published case with such association has been described. The loud mitral insufficiency murmur hide the continuous murmur of the fistula. The angiographic study demonstrated the A... | 475,502 | [
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Severe anemia. Clinical observations in 100 patients with very low hemoglobin levels. | One hundred consecutive patients with hemoglobin concentration less than 3.5 g/dL (hematocrit reading, less than 10%) were admitted to the University of Baghdad Teaching Hospital, Iraq, during a 30-month period. Twenty-eight patients had aplastic anemia, 27 had leukemia or other hemopoietic malignancies, 16 had chronic... | 475,523 | [
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Upper extremity lymphedema in filariasis. | Arm lymphedema associated with shoulder pain and axillary lymphadenopathy was diagnosed in a 40-year-old California man. This is an unusual domestic presentation of filariasis, an endemic tropical disease that is often asymptomatic and undiagnosed. Prognosis for recovery is excellent with the diethylcarbamazine citrate... | 475,525 | [
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Effect of hemodialysis on glucose tolerance in children with chronic renal failure. | Five uremic (7.0 - 15.2 years), non-dialyzed children treated medically (group 1) had an intravenous glucose tolerance test (0.5 g/kg). Blood samples were obtained at frequent intervals and duplicate determinations of plasma glucose (glucose-oxidase method on Somogyi-Nelson protein-free filtrates), insulin and free fat... | 475,539 | [
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The influence of 6-hydroxydopamine and 6-hydroxydopa on the phospholipids content in the brain of rats. | 6-hydroxydopamine and 6-hydroxydopa injected intraperitoneally in dose of 50 microgram/g in newborn rats, two and six weeks old caused a drop in content of phosphatidylcholine and phosphatidylserine, and an increase in content of phosphatidylinositol in the brains of two weeks old rats treated with 6-hydroxydopamine in... | 475,556 | [
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Experimental studies of the etiology of genital exhibitionism. | Several studies are reported which examine the critical stimuli and responses as well as personality factors important in genital exhibitionism. Using penile volume measurement, sex history questionnaires, personality tests, and behavioral observations, it was found that (1) exhibitionists responded most to mature fema... | 475,579 | [
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Ego development and sex attitudes in heterosexual and homosexual men and women. | A comparison was made of heterosexual and homosexual men and women utilizing Loevinger's concept of ego development and focusing on the relationships among ego levels and attitudes toward homosexuality and on personal sex guilt and other sociosexual variables. Previous comparative studies were critically analyzed with ... | 475,581 | [
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Pigmentary dispersion and glaucoma. A new theory. | A new theory states that mechanical rubbing between anterior packets of zonules and the peripheral iris in predisposed eyes is the cause of the loss of iris pigment in pigmentary glaucoma and in the pigmentary dispersion syndrome. The peripheral radial defects were in close approximation to anterior packets. The total ... | 475,638 | [
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Transmastoid decompression of the facial nerve in Bell's palsy. | We describe the technique of decompression of the facial nerve from the geniculate ganglion to the stylomastoid foramen. The decompression was made on 51 patients with Bell's palsy, and the results of follow-up study were compared with those of 77 patients in whom the pyramidal and vertical segments were decompressed. ... | 475,650 | [
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Effect of urea on osmolality of perilymph. | Blood osmolality was altered in chinchillas by intravenous administration of urea. Serum osmolality peaked rapidly at 30 minutes after administration and decreased slightly to a plateau for 180 minutes. Perilymph and CSF osmolality lagged substantially behind the increase in serum osmolality and equaled serum osmolalit... | 475,652 | [
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Resistance to thiabendazole in a field population of Ostertagia circumcincta from sheep. | A population of Ostertagia circumcincta from sheep has been found which, in field and laboratory trials, showed a lack of response to the recommended dose (44 mg/kg) of thiabendazole, suggesting that a degree of resistance exists to this anthelmintic. Preliminary experiments indicated a less than expected response to l... | 475,679 | [
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Effect of adding superphosphate to the drinking water on the fertility of dairy cows. | Mean serum inorganic phosphorus concentrations of cows in an infertile dairy herd of 170 cows in the Hunter Valley increased from less than 4.5 mg/100 ml to greater than 5.8 mg/100 ml after defluorinated superphosphate was added to their drinking water at the rate of 2.5 kg/450 1 once weekly from September, 1976. The f... | 475,681 | [
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Psychiatric aspects of adaptation to long submarine missions. | The case histories of 261 submarines disqualified psychiatrically for further submarine duty revealed that the major symptomatology was emotional in nature, with character pathology second in frequency. The latter pathology resulted in disqualification much earlier than the former, a fact indicative of effective neurot... | 475,704 | [
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Long term effects of the anorectic agent fenfluramine alone and in combination with aminorex on pulmonary and systemic circulation in the pig. | We have investigated the effects of chronic oral administration of two anorectic substances, fenfluramine and aminorex, especially on the pulmonary circulation in young pigs with one ligated pulmonary artery. The pulmonary vascular reactivity was tested by alveolar hypoxia, alveolar hyperoxia and infusion of prostaglan... | 475,736 | [
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Substrate effects on mitochondrial function and tissue lipids in low-flow hypoxia of isolated perfused rat hearts. | A possible causal relationship between tissue FFA contents and the depression in mitochondrial oxidative phosphorylation in myocardial ischaemia has been suggested. To test this hypothesis, the effects of different substrates added to the perfusates of hypoxic, low-flow perfused hearts were examined on oxidative phosph... | 475,735 | [
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2-Sulphobenzyl, a new solubilizing and reversible protecting group for cysteine in proteins. Its scope and limitations. | S-2-Sulphobenzylcysteine and S-2-(sulphomethyl)benzylcysteine are prepared by alkylation of cysteine with omega-toluenesultone and 2,3-benzo-1,4-butanesultone respectively. Owing to the presence of the sulphonic acid group, these protected cysteine derivatives are extremely water-soluble and are stable to acid hydrolys... | 475,751 | [
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Analysis of the ratio of alpha- to beta-globin and globin messenger ribonucleic acid content of fractionated rabbit erythroid bone-marrow cells. | The ratio of alpha- to beta-globin mRNA was measured by hybridization of a constant amount of highly purified alpha- or beta-globin cDNA (complementary DNA) with increasing amounts of RNA in the range up to 20% cDNA hybridization, where an essentially linear reaction is obtained. Statistical analysis indicates that the... | 475,765 | [
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The multiple forms of alpha-D-mannosidase in human plasma. | The acidic alpha-D-mannosidase in human plasma closely resembles liver acidic alpha-D-mannosidase in its affinity for concanavalin A-Sepharose, molecular weight and resolution into multiple components on DEAE-cellulose. A combination of chromatography on concanavalin A-Sepharose and gel filtration on Sephadex G-200 and... | 475,769 | [
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The reaction of menadione with haemoglobin. Mechanism and effect of superoxide dismutase. | 1. Menadione was found to react with both the haem groups and the beta-93 thiol groups of haemoglobin. 2. It oxidized the haem groups of oxyhaemoglobin, giving mainly methaemoglobin and a smaller amount of haemichrome. The reaction rate was decrease in the presence of catalase and markedly accelerated in the presence o... | 475,774 | [
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The determination of binding parameters when the total and free substrate concentrations are not approximately equal. | By using a standard graphical method values of Km and V may be found that are independent of the conditions and assumptions that the total substrate concentration approximates to its free concentration and that Km is much larger than the enzyme concentration. The procedure is also applicable to the determination of equ... | 475,775 | [
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The separation of sheep liver cytoplasmic and mitochondrial aldehyde dehydrogenases by isoelectric focusing, and observations on the purity of preparations of the cytoplasmic enzyme, and their sensitivity towards inhibition by disulfiram. | Preparations of sheep liver cytoplasmic aldehyde dehydrogenase obtained by published methods were found by analytical isoelectric focusing in the pH range 5--8 to contain 5--10% by weight of the mitochondrial aldehyde dehydrogenase. Under the conditions used the pI of the cytoplasmic enzyme is 6.2 and that of the mitoc... | 475,776 | [
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[Abdominal manifestations of chronic pyelonephritis]. | The most frequent abdominal complaints in chronic pyelonephritis are analyzed and one patient is described, who with the exacerbation of the disease manifested the clinical picture of acute abdomen. The involvement of visceral-dermal reflexes with hyperalgesia, muscular defense, vomiting, meteroism and disturbances in ... | 475,896 | [
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[Malignant, rapidly progressing nephritis in Schönlein-Henoch disease]. | A case of malignant quickly progressing Henoch-nephritis is described, with a lethal end one and a half month after the initial manifestations. The disease develops with a clinical picture typical for systemic vasculitis, with joint-pain, skin-rash and grave abdominal syndrome, being the reason for unnecessary surgical... | 475,902 | [
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Coronary artery spasm of different degrees as cause of angina at rest with ST segment depression and elevation. | Chest pain induced by ergometrine was associated with ST depression and subsequent elevation in anterior leads in a 42-year-old man suffering from angina at rest. Coronary arteriography during the attack showed that coronary arterial spasm of different degrees was responsible for chest pain and both types of electrocar... | 475,928 | [
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Double outlet from chambers of left ventricular morphology. | This series of 5 cases with double outlet of morphologically left ventricular chamber includes 4 found during a review of 1700 heart specimens (incidence 0.23%) and 1 found at operation and successfully corrected. Abnormal atrioventricular connection precluding total correction was present in the 4 anatomical cases. Cl... | 475,930 | [
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0.0642722,
0.04520861,
-0.1113768,
0.2196845,
0.4144839,
-0.2... |
Antibody-dependent cellular cytotoxicity to human colon-tumour cells. I. Lack of tumour specificity in a population study. | The humoral and cellular components of the antibody-dependent cellular cytotoxicity (ADCC) against allogeneic human colonic tumour cell lines were evaluated. The 2 colon cell lines used in this study (HT-29 and ACC-20) were found by immunofluorescence to have carcinoembryonic antigen (CEA) on their surface, and to beco... | 475,969 | [
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In vitro prediction of the pathogenicity of mineral dusts. | Eight mineral dusts, of which 7 were fibrous, were tested in 3 in vitro systems. The dusts had previously been tested for their ability to produce mesotheliomata in rats. The in vivo and in vitro biological activities of these dusts are compared with the number and size of fibres they contain. It is concluded that all ... | 475,978 | [
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Melanotic freckle of Hutchinson: treatment of macular and nodular phases with cryotherapy. | Fourteen cases of Hutchinson's lentigo maligna and eight further cases with nodular invasive areas in whom liquid nitrogen spray has been curative are reported. We suggest that in view of its simplicity and efficacy, cryotherapy is the treatment of choice for the macular phase and possibly also for the nodular invasive... | 475,986 | [
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Effect of antilymphocyte globulin on granulocyte precursors in aplastic anaemia. | Granylocyte colony forming units (CFU-C) were studied in 22 patients with severe aplastic anaemia before and after treatment with antilymphocyte globulin (ALG). Nine patients showed a clinical response to ALG characterized by a rise in the granulocyte count to over I X 10(9)/1 within 30 d. These patients were distingui... | 475,996 | [
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Coagulation abnormalities produced by plasma exchange on the cell separator with special reference to fibrinogen and platelet levels. | Five patients with immunopathologic renal disease, 12 with malignant paraproteinaemia and one with myasthenia gravis underwent a total of 179 plasma exchanges on a continuous flow cell separator. Replacement fluids devoid of coagulation factors were used in 160 exchanges while 19 exchanges were replaced with Fresh Froz... | 476,011 | [
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A genetic variant of factor IX with decreased capacity for Ca2+ binding. | A genetic variant of factor IX is described that behaves identically to PIVKA/IX (the precursor factor IX molecule induced by the absence of vitamin K or presence of vitamin K antagonists, acarboxy factor IX). It shows an increased electrophoretic mobility in the presence of Ca2+, a low affinity for adsorption to A1(OH... | 476,013 | [
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Routine induction of labour with extra-amniotic prostaglandin E2 in a viscous gel. | Prostaglandin E2, 350 microgram dispersed in a viscous gel, tylose, was introduced into the extra-amniotic space as a single dose in 285 patients to induce labour. With a favourable cervix, 82 per cent of multiparae and 50 per cent of primiparae were successfully induced. With unfavourable induction features, the succe... | 476,018 | [
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Multiple births in former oral contraceptive users. | Multiple births were studied in a cohort of 2953 former oral contraceptive users and 13,630 controls, all the women were interviewed post partum. There were 238 multiple births, a rate of 14.4/1000 deliveries. Former oral contraceptive users had 13.5/1000 sets of multiple births compared to 14.5/1000 in the controls. W... | 476,022 | [
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0.3681055,
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Dark adaptation in diabetes mellitus. | The effect of diabetes mellitus on the normal dark adaptation curve is investigated. It has been found that diabetic patients take longer to adapt and that their absolute thresholds are raised. The degree of elevation in the final threshold correlates with the duration of diabetes. | 476,028 | [
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Blepharochalasis. | The condition of blepharochalasis and its treatment are discussed. Four cases are presented which show a physical sign that may help in its diagnosis. | 476,029 | [
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The relationship between protein turnover and energy balance in lean and genetically obese (ob/ob) mice. | 1. Groups of lean and genetically obese (ob/ob) mice were adapted to varying energy intakes and the rates of total protein turnover in liver, gut and kidney were measured. 2. Lean mice gained less weight when fed above maintenance and lost less weight when fed below maintance than obese mice. 3. Hepatic protein turnove... | 476,036 | [
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Histone gene switch in the sea urchin embryo. Identification of late embryonic histone messenger ribonucleic acids and the control of their synthesis. | During embryogenesis in the sea urchin Strongylocentrotus purpuratus, there is a shift from one histone mRNA population to another. The early and late embryonic histone mRNAs, previously shown to differ considerably in sequence from each other by hybrid melting studies, are shown here to differ also in electrophoretic ... | 476,047 | [
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Antigody-nucleic acid complexes. Inhibition of translation of silkmoth chorion messenger ribonucleic acid with antibodies specific for 7-methylguanosine. | Antibodies specific for 7-methylguanosine (m7G) were evaluated for their ability to inhibit the translation of chorion mRNA in a wheat germ, cell-free amino acid incorporating system. Results obtained with antibody concentrations of 0.5--1.5 microM revealed dose-dependent inhibition of [3H]-labeled amino acid incorpora... | 476,089 | [
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Factors regulating the elongation of palmitic and stearic acid by rat liver microsomes. | Analysis of the rates of overall chain elongation and condensation of malonyl-CoA with palmitoyl-CoA and stearoyl-CoA as primers demonstrated that for each primer, the rate of the overall metabolic process was similar to the initial condensation. The specific activity for condensation with palmitoyl-CoA was eleven time... | 476,133 | [
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Isolation and structure of diglycosylsterols and triglycosylsterols in rice bran. | Novel oligoglycosylsterols, a series of sterylglycosides, were detected in the glycolipids of rice bran, and di- and triglycosylsterols were isolated and their structures were investigated. The principal sterol components were sitosterol, campesterol and stigmasterol; glucose was the only component sugar. The major spe... | 476,140 | [
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Absorption, serum levels and urinary excretion of inorganic sulfate after oral administration of sodium sulfate in the conscious rat. | The absorption of inorganic sulfate after ingestion was investigated in rats. After oral administration of Na235SO4, 35S radioactivity was measurable in plasma already after 15 min and its plasma concentration reached a peak after about 1.5--2 h. The 35S-radioactivity excreted in urine during 24 h after ingestion of Na... | 476,150 | [
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ADP-ribosylation of membrane proteins and activation of adenylate cyclase by cholera toxin in fat cell ghosts from euthyroid and hypothyroid rats. | Incubation of fat cell ghosts with activated cholera toxin, nucleoside triphosphate, cytosol, and NAD results in increased adenylate cyclase activity and the transfer of ADP-ribose to membrane proteins. The major ADP-ribose protein comigrates on sodium dodecyl sulfate-polyacrylamide gels with the putative GTP-binding p... | 476,151 | [
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Plasma thyroid hormones and cholesterol in the newborn of genetically different types of cattle in a tropical environment. | The patterns of plasma concentrations of thyroxine (T4), triiodothyronine (T3) and cholesterol were determined in tropically adapted (ZX) and temperate (SH) breeds of cattle in the first 6 days of their lives in a tropical environment. T4 concentrations were high at birth and fell to within normal adult values at 6 day... | 476,214 | [
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Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures. | Experiments were carried out to test the hypothesis that the differences between the surfaces of erythrocytes from normal and sickle cell patients are reflected in the degree of attachment to the capillary lining. An assay was used that measured the number of 51Cr-labeled erythrocytes (normal or sickle) attaching to a ... | 476,304 | [
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Congenital dyserythropoietic anemia type I: report of a pair of siblings in Japan. | This is the first case of two siblings with congenital dyserythrobpoietic anemia (CDA) type I to be reported from a Japanese family. Both of these cases showed characteristic morphological aberration of erythroid precursors, ineffective erythropoiesis, and negative acidified serum test. The ultrastructural study of ery... | 476,312 | [
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Erythrocyte agglomeration and survival studies in citrate-phosphate-dextrose (CPD) units. | We have previously reported increased tendency to agglomeration in CPD-stored erythrocytes. In the present study we investigated the deterioration pattern of fresh units, as detected by agglomeration, free hemoglobin levels, ATP levels, osmotic fragility, and certain enzymatic activities. When the negative test was con... | 476,313 | [
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Human cold agglutinins against "cryptic" erythrocyte antigens. | Two examples of human IgM cold agglutinins agglutinated human RBC only after enzyme treatment in vitro. Proteases were optimally effective, neuraminidase was also effective. The cold agglutinins did not coat native RBC but were directed against "cryptic" RBC determinants. The cold agglutinins belonged to the anti -I/-i... | 476,314 | [
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A regional cooperative acquisition program for monographs. | A cooperative acquisition program for monographs for the twelve resource libraries in Region IX of the Regional Medical Library Network is described. Each of the participating libraries has agreed to purchase all books of an assigned publisher which fall within a prescribed subject-format profile. It is hoped that this... | 476,317 | [
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Motivation, responsibility and sickness in the psychiatric treatment of alcoholism. | Two dominant themes of alcohological thinking and practice are considered in this paper; the disease concept and the concept of motivation. Both are examined in terms of (a) the rights, obligations and responsibilities associated with different types of illness and degrees of severity, and (b) the routine care and trea... | 476,354 | [
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Origin of descending afferents to the rostral part of dorsal cap of inferior olive which transfers contralateral optic activities to the flocculus. A horseradish peroxidase study. | Neurons in the ventromedial tegmental area that project to the rostral part of the dorsal cap of the ipsilateral inferior olive were labeled by the technique of retrograde transport of horseradish peroxidase (HRP). Following iontophoresis of HRP into the rostral part of the dorsal cap a cluster of labeled cells are fou... | 476,490 | [
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Lipid requirements for the aggregation of CTP:phosphocholine cytidylyltransferase in rat liver cytosol. | Two forms of CTP:phosphocholine cytidylyltransferase were identified in rat liver cytosol by gel filtration chromatography. The low molecular weight form (L form) is the major form in fresh cytosol. The enzyme associates into a high molecular weight form (H form) upon storage of the cytosol at 4 degrees C. Aggregation ... | 476,509 | [
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Immunologic evidence that staphylococcal alpha toxin is oriented on membranes. | Antibodies to staphylococcal alpha toxin were separated into two distinct populations. One population prevented binding of alpha toxin onto erythrocyte membranes. The other population neutralized after the toxin was bound onto erythrocytes and thereby brought about an indirect hemagglutination reaction. The data sugges... | 476,546 | [
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0.136187,
-0.1882543... |
Effect of oxygen on batch and continuous cultures of a nitrogen-fixing Arthrobacter sp. | Growth, acetylene reduction, and respiration rate were studied in batch and continuous cultures of Arthrobacter fluorescents at different oxygen partial pressures. The optimum pO2 values for growth and acetylene reduction were 0.05 and 0.025 atm, respectively, but microorganisms can tolerate higher pO2 values. The grow... | 476,551 | [
-0.003045815,
-0.4440794,
0.06413468,
0.1808081,
-0.4234328,
-0.08438819,
-0.05859919,
0.1656463,
0.2265467,
-0.1309495,
-0.2087596,
-0.2138696,
-0.1466115,
-0.09809428,
-0.5024381,
-0.2065062,
-0.5094514,
0.0261086,
-0.02886773,
0.5860692,
0.1873003,
0.01440869,
0.083497... |
Necrolytic migratory erythema, presenting as candidiasis, due to a pancreatic glucagonoma. | A 54-year-old male with diabetes, weight loss, glossitis and Candidiasis presented with the typical cutaneous eruption of necrolytic migratory erythema. The suspicion of pancreatic glucagonoma was confirmed by an elevated plasma glucagon level. Surgical removal of the pancreatic alpha cell tumor resulted in a complete ... | 476,569 | [
0.1501788,
-0.4003955,
-0.3840477,
-0.2624189,
0.05223529,
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0.006509198,
-0.1730052,
-0.1100718,
0.1894315,
0.1585675,
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0.02946193,
-0.08791544,
-0.2119852,
0.1502087,
-0.06416146,
0.2449534,
0.1207266,
-0.2306743,
0.1854478,
0.2982437,
0.1447341,
... |
Multicystic, peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). | A 27-year-old Caucasian female complained of persistent, poorly localized abdominal pain of several months' duration, found to be due to a multicystic diffuse lesion involving omentum, peritoneum and pelvic viscera. Three resections were required within a ten-month period for symptomatic control. The tumor showed many ... | 476,578 | [
0.05164384,
-0.003703028,
-0.3876457,
-0.1866504,
-0.3295582,
-0.1488726,
-0.1976582,
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0.2256075,
-0.1351603,
0.3063697,
0.015406,
-0.06530888,
-0.002797977,
-0.2120239,
0.01156838,
-0.3532469,
-0.05569591,
0.2426438,
-0.2690735,
0.02173745,
0.3310038,
-0.01238... |
Prognostic factors in metastatic and hormonally unresponsive carcinoma of the prostate. | Eighty-eight patients with hormone-resistant Stage IV prostate cancer were treated with a five-drug chemotherapy program. Patient demographic data, prior therapy, symptoms, extent of disease, and laboratory studies were analyzed statistically to evaluate the association of these parameters with survival from the onset ... | 476,583 | [
0.242833,
-0.1956767,
0.1597082,
-0.3215278,
-0.666573,
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0.1798614,
0.06650949,
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0.1432895,
0.2220959,
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-0.004132124,
-0.02571216,
0.1668862,
0.2660448,
-0.02148213,
0.02092335,
-0.3635933,... |
Hemangioendothelial sarcoma of penis. | Hemangioendothelial sarcoma of the penis in a 44-year-old man was treated by preoperative radiation, penectomy, and chemotherapy. The patient was free of evident disease 2 years later. Electronmicroscopy showed differentiated vascular structures at the periphery of the lesion and anaplastic cells throughout the remaind... | 476,592 | [
-0.07656492,
-0.02327245,
-0.07469728,
-0.1573951,
-0.06226151,
-0.2609653,
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-0.1764274,
0.2215867,
0.2649689,
0.3762244,
0.1238158,
-0.2791685,
-0.3085549,
-0.1253038,
-0.01970894,
-0.2947834,
0.1206942,
0.07854374,
-0.02699563,
0.481428,
0.1973554,
0.129560... |
Effect of the duration of retinyl acetate feeding on inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis in the rat. | The effect of the duration of retinoid treatment on the inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis was studied. Female Sprague-Dawley rats were given i.v. injections of 50 mg 1-methyl-1-nitrosourea per kg body weight at both 50 and 57 days of age. Feeding of a placebo diet or diet supplemented ... | 476,636 | [
-0.04309476,
0.0765218,
-0.5600066,
-0.4223911,
0.04997423,
-0.2656163,
0.04214898,
-0.02287119,
0.02441552,
0.1161472,
0.1727423,
0.310718,
0.1489428,
-0.1021769,
-0.1646894,
-0.007904081,
-0.4390827,
0.1089125,
0.3269688,
0.05275979,
0.3502924,
0.3153654,
-0.03704461,
... |
Enhancement of the nuclear reactivity of alkylating agents by prednisolone. | We have compared the nuclear reactions of the alkylating agents chlorambucil, melphalan, and cyclophosphamide used alone, with those produced when the same drugs were used in combination with the corticosteroid prednisolone. Studies were performed in vivo in Wistar rats bearing ascites forms of either the Yoshida sarco... | 476,658 | [
0.1445171,
0.01223424,
0.2732425,
-0.2922021,
0.05239839,
-0.09520635,
-0.05861331,
0.09528833,
0.2248028,
0.1489215,
0.07157394,
-0.0001307508,
-0.1166456,
0.2469949,
-0.2553841,
-0.1126311,
-0.4286929,
-0.187509,
0.0008612634,
0.2116205,
0.2195111,
-0.4759027,
-0.155762... |
An estimate of the maximum in vivo covalent binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to rat liver protein, ribosomal RNA, and DNA. | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an extraordinarily potent toxin, has recently been found to be a potent carcinogen producing mucosal, lung, and liver tumors in female rats. In light of this carcinogenicity, we reexamined the in vivo covalent binding of [3H]TCDD to rat liver macromolecules. Immature Sprague-... | 476,664 | [
-0.07040774,
-0.04509199,
-0.1410433,
-0.2057943,
0.2155945,
0.09482898,
-0.1164922,
0.3218,
0.2260374,
-0.1554268,
0.2583298,
0.2842567,
0.1753986,
-0.09600965,
-0.2515019,
0.04209127,
-0.3400641,
-0.1846505,
0.3575661,
0.1959506,
0.1644481,
0.316064,
-0.08322193,
-0.0... |
Early effects of dimethylnitrosamine on protein chain initiation and postmicrosomal polyadenylic acid-containing RNA content in mouse liver. | A mouse liver S-30 system was used to study the early effects of dimethylnitrosamine (DMNA) on polypeptide chain initiation and messenger RNA content. The inhibition of protein synthesis after DMNA administration was associated with a reduced capacity of the S-30 system to form 80S ribosomal initiation complexes. The b... | 476,665 | [
-0.1492347,
0.1037091,
-0.0239763,
0.02186338,
0.4723693,
0.1399389,
0.06767341,
0.02007899,
0.2497956,
-0.001515694,
-0.09885932,
0.01484603,
0.2576061,
0.1729521,
-0.3218409,
0.2780644,
0.07409091,
0.0243276,
-0.02292696,
0.2786638,
0.1493529,
-0.02185006,
0.04765125,
... |
Metabolic activation of arylhydroxamic acids by N-O-acyltransferase of rat mammary gland. | The lactating mammary glands of rats contain an arylhydroxamic acid N,O-acyltransferase that catalyzes the formation of arylamine-substituted nucleic acid on incubation with N-hydroxy-N-2-acetylaminofluorene or N-hydroxy-N-4-acetylaminobiphenyl and transfer RNA. The acyltransferase activity migrates as a single compone... | 476,668 | [
-0.1506652,
-0.1377041,
-0.227459,
-0.2620695,
0.02949068,
-0.06735777,
-0.2430029,
0.08608244,
0.2185236,
0.04766795,
0.2771978,
0.111522,
0.3265425,
-0.004197015,
-0.1490641,
0.05514421,
-0.2905167,
-0.04046691,
0.06181464,
-0.03979423,
0.2522497,
0.108535,
-0.08441968,... |
Effects of daunorubicin and doxorubicin, free and associated with DNA, on hemopoietic stem cells. | We have compared daunorubicin (DNR)-DNA with free DNR and doxorubicin (DOX)-DNA with free DOX for their effects in vivo in mice on pluripotent stem cells and granulocytic committed stem cells. Dose-survival, time-survival, and recovery curves were obtained after one i.v. injection of either drug. The dose-survival curv... | 476,697 | [
-0.1390642,
-0.3582157,
-0.3434957,
-0.4173909,
0.5714176,
-0.04216247,
0.004825721,
-0.01464017,
-0.04374181,
0.199955,
-0.04731205,
0.3731872,
-0.2756849,
0.2983865,
-0.4896274,
-0.0835371,
-0.2173886,
0.1863677,
0.003905668,
0.1471272,
0.6255151,
0.03953843,
0.00727354... |
Effect of dietary fiber on the induction of colorectal tumors and fecal beta-glucuronidase activity in the rat. | The purpose of the present study was to investigate whether three different types of dietary fiber, wheat bran, carrot fiber, and citrus pectin, influenced the induction of colorectal tumors produced by 1,2-dimethylhydrazine in rats. In all groups, the tumor yield was high (87 to 97%). In the wheat bran and carrot fibe... | 476,699 | [
-0.007080363,
0.02719207,
-0.2907319,
0.3714997,
0.1953445,
-0.6660914,
-0.02435118,
0.1510602,
-0.1180454,
0.2069731,
0.07108495,
0.02227402,
0.1398904,
-0.1472149,
-0.2827855,
0.3143188,
-0.736982,
-0.01724225,
-0.01458186,
-0.1709105,
0.5393883,
0.04148296,
0.01905923,... |
Estimation of effective eosinopoiesis and bone marrow eosinophil reserve capacity in normal man. | The eosinophil reserve capacity of the post-mitotic granulocyte compartment in the bone marrow and the effective eosinopoiesis in three haematologically normal men have been quantified by means of kinetic parameters of [3H]thymidine flash-labelled peripheral blood eosinophils. From (a) the time of the appearance in the... | 476,773 | [
0.05883145,
-0.1023514,
-0.3450496,
-0.35691,
0.09947926,
-0.342227,
0.1170165,
-0.1117295,
-0.543788,
0.08668382,
-0.1763395,
0.08454123,
-0.07425881,
0.5271956,
-0.8502482,
-0.2868857,
0.0633487,
0.03934215,
0.2541188,
0.3178288,
0.2693539,
0.3198359,
-0.06040913,
-0.... |
Non-random association of mitotic cells from cultured human lymphocyte suspensions. | By using chromosome markers in two separate cell lines of a human dispermic chimera, it was shown that 4.9% of metaphases in suspensions of PHA-cultured lymphocytes were paired because of non-random factors. A similar amount of metaphase pairing occurred in cultured lymphocytes of normal donors, and evidence from the r... | 476,780 | [
0.01184779,
-0.06494129,
-0.1851497,
-0.03482556,
0.400225,
-0.2055103,
-0.3225637,
0.2411886,
0.1476858,
0.1696735,
0.004447511,
0.1298124,
0.07048254,
0.3164703,
-0.5801,
-0.1692083,
-0.4190133,
0.01606435,
-0.1695563,
0.1551317,
0.3226337,
0.1113001,
-0.0335144,
-0.1... |
A combined horseradish peroxidase and Golgi study on the afferent connections of the ventrobasal complex of the thalamus in the cat. | Afferent connections to the ventrobasal complex (VB) of the thalamus were studied by means of retrograde transport of horseradish peroxidase (HRP) and by the Golgi-method. After HRP-injection into the VB, peroxidase-positive cells were observed contralaterally in the dorsal column nuclei (DCN), in the trigeminal nuclei... | 476,813 | [
0.2163345,
-0.2627398,
0.1572858,
0.1944996,
0.01249954,
-0.4844526,
-0.2087755,
-0.2665712,
-0.1562191,
0.2249599,
-0.06361124,
-0.04418997,
-0.2546945,
-0.06561878,
-0.1619475,
-0.04045535,
-0.5084258,
0.2638397,
0.296618,
0.1255805,
0.08048925,
0.3502537,
0.1425947,
... |
Morphogenesis in Volvox: analysis of critical variables. | Inversion, the process by which Volvox embryos turn inside out, was analyzed by a combination of geometrical and experimental techniques. It was shown that simple geometric figures are adequate to represent cell shapes during inversion and that cell volumes remain constant as cell shapes change and the embryo inverts. ... | 476,832 | [
-0.2608483,
0.02061783,
-0.2591263,
0.006456404,
0.2865865,
-0.2858536,
-0.09219902,
-0.08414429,
0.3375173,
0.1901083,
-0.1617662,
-0.09416723,
-0.4138981,
0.1232325,
-0.3381002,
0.09631693,
-0.5675495,
0.05815675,
-0.2196775,
0.2414435,
0.9679825,
0.3537382,
-0.3309014,... |
Asthma, IgE and environment in northern Nigeria. | Sixty-four asthmatics and seventy-five control subjects from rural villages and various urban settings have been investigated. Rural asthmatics had a significantly higher IgE level than both urban asthmatics and village controls. Urban asthmatics had similar IgE levels to urban controls. There was no relationship betwe... | 476,907 | [
0.1678808,
-0.1932701,
0.04588645,
-0.1975421,
0.04698445,
0.05140703,
-0.2406419,
-0.124016,
0.1746991,
-0.1192952,
0.1351634,
0.05778959,
0.1809152,
0.07249932,
-0.2924024,
0.128452,
-0.3457396,
0.04673193,
-0.1409913,
-0.05489781,
-0.2437825,
0.4007693,
0.02839503,
-... |
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