title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Treatment of superficial cancers by combination hyperthermia and radiation therapy. | Clinical studies are being carried out to evaluate whether radiation combined with hyperthermia evokes better tumor control than that achieved with radiation alone. Thus far, 54 patients with various superficial cancers have been treated with combination hyperthermia and radiation. The heating methods used have been te... | 476,911 | [
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Comparison of theophylline concentrations in venous blood and capillary blood in asthmatic children. | Twenty children, five to 16 years old, diagnosed as having asthma, were studied to compare the serum concentrations of theophylline obtained by standard venipuncture with capillary concentrations obtained by finger lancet. The mean theophylline concentration in venous samples was 9.27 mg/L and in capillary samples was ... | 476,937 | [
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A commercial digoxin radioassay modified for use as an emergency ("stat") procedure. | A recent "stat" procedure recommended by the manufacturer for use with a commercial digoxin radioassay involves doubling the amount of antibody used in the regular procedure, to compensate for the decrease in binding that results from use of a shorter (10 min) incubation. This has two obvious disadvantages: increased m... | 476,939 | [
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Automated analysis of hydroxyproline with elimination of non-specific reacting substances. | A modified urinary hydroxyproline method is presented which utilizes an automated technique, Technicon instrumentation and Ehrlich's reagent. Acid hydrolysates are neutralized automatically. Non-specific reacting substances are determined simultaneously with each sample and subtracted as a blank. This method has been f... | 476,953 | [
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Aggregation-induced stability of dexamethasone receptors in rat kidney. | The stability of the dexamethasone-receptor complex of rat kidney cytosol was studied using homogenizing media of varying pH and composition. It was found that the complex is less stable with buffers usually employed for the study of steroid receptors such as Tris, EDTA etc., whereas the stability increases considerabl... | 476,963 | [
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Disturbed mineral metabolism in hyperthyroidism: good correlation with tri-iodothyronine. | Mineral metabolism is frequently disturbed in hyperthyroidism. In a group of seventy-two patients with hyperthyroidism, we observed an increase in serum diffusible calcium in 50% of the cases, elevated inorganic phosphorus in 30% and elevated alkaline phosphatase in 44% of the cases. Correlations existed between the va... | 476,975 | [
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The effect of somatostatin on metabolic and hormonal changes during and after exercise. | The effect of intravenous somatostatin on blood levels of metabolites and hormones has been examined in normal subjects who performed a 30-minute period of bicycle exercises at 70% maximal exercise capacity. The results have been compared with control studies in the same subjects. Measurements were made of blood levels... | 476,977 | [
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Mineralocorticoid replacement in Addison's disease. | Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2-week periods on each dose. In two p... | 476,980 | [
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Free-running circadian plasma cortisol rhythm in a blind human subject. | The plasma cortisol rhythm in man has been presumed to be an endogenous circadian rhythm, synchronized by some external stimulus to an exact 24-h period. Sleep/wake and 'social activity' cycles have been considered as candidates for this synchronizer. Previous studies have suggested that the dark/light phase shifts ass... | 476,985 | [
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Otosclerosis and pregnancy: a study of the influence of pregnancy on the hearing threshold before and after stapedectomy. | In a retrospective study of 144 fertile women subjected to operation for otosclerosis by the method of Shea or House, we found a fall in the hearing threshold in the operated ear which seemed to be a little greater in the patients who became pregnant after the operation than in those who did not. However, the hearing l... | 476,990 | [
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Anthropometry in the Cri du Chat syndrome. | Anthropometric and cranial X-ray measurements of 35 individuals with a 5p- karyotype showed a general growth retardation. Height, weight, circumference of the thorax, pelvic breadth, and the size of the skull, face, hands and feet were all subnormal. Only the inner canthal distance was moderately increased, especially ... | 477,023 | [
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Transfer factor and hepatitis B: a double blind study. | A prospective, double blind placebo-controlled trial was carried out on twenty-nine patients with hepatitis B. Thirteen received transfer factor and sixteen placebo. There were no significant differences between the two groups in any clinical or laboratory measurements made, although a rapid early reduction of serum as... | 477,025 | [
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Acute bilateral anterior dislocation of the shoulders. | In 3 cases of simultaneous bilateral anterior dislocation of the shoulders, considering the forces which predispose to anterior dislocations, it is postulated that in each case forced abduction and external rotation or abduction with hyperextension causes these injuries to occur. | 477,076 | [
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Circulatory and vascular changes in the hip following traumatic hip dislocation. | An experimental study of the extraosseous and intraosseous vascular and circulatory changes following traumatic hip dislocation in dogs and rabbits is reported. The observations were made by dissection, angiography and histology following posterior dislocation and reduction at varying intervals. Traumatic dislocation o... | 477,079 | [
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Experimental knee instability: early mechanical property changes in articular cartilage in a rabbit model. | Utilizing a knee joint instability model for traumatic osteoarthritis, quantitative measurements of the biomechanical properties of the articular cartilage demonstrate that the cartilage deforms and that the deformation rapidly occurs within 24 hours of injury. These changes in mechanical properties may be a more sensi... | 477,081 | [
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Femoral shaft perforation: a complication of total hip reconstruction. | Perforation of the femoral shaft by the stem of the prosthesis is a rare, but serious complication following total hip replacement. It is a complication that is avoidable if meticulous attention is given to preoperative planning and intraoperative technique. The major predisposing factors for this complication are prev... | 477,097 | [
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Intertrochanteric fractures of the hip in the elderly: a retrospective analysis of 236 cases. | A series of 236 patients over the age of 80 with intertrochanteric fractures were treated on a protocol established basis in an attempt to decrease postoperative morbidity and mortality. Rigid fixation with interfragmentary compression using the compression hip screw permitted us to begin early mobilization and immedia... | 477,104 | [
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Growth of osteoid osteoma transplanted into athymic nude mice. | An osteoid osteoma, excised from the neck of the femur of a 23-year-old man, was cut into four 1.5 mm3 fragments and immediately transplanted into muscle pouches in athymic nude mice. One fragment was devitalized by lyophilization before implantation. The viable tumor cell xenografts grew, differentiated into uncalcifi... | 477,116 | [
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A method for determining success following total hip replacement surgery. | The success of a total hip replacement surgery, using the hip evaluation form, was investigated in 2 groups of surgical patients which differed in terms of relative success of surgery. For the men, the group which did not respond as well to surgery had less education and were more retired individuals; this group also h... | 477,123 | [
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Femoral component loosening after total hip arthroplasty. | To determine the long-term durability of total hip arthroplasty and to identify factors responsible for femoral component loosening, 106 total hip arthroplasties were reviewed in patients with a minimum postoperative period of 3 years. Seventy-four had Charnley-Müller prostheses and 32 had Charnley prostheses. Femoral ... | 477,126 | [
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Brain scintigraphy in arteriovenous malformation. | Brain scintigraphy demonstrated an unusual image pattern which was associated with an arteriovenous malformation (AVM). A preoperative diagnosis of AVM was suspected on the radionuclide study and confirmed by contrast angiography and surgery. We review the criteria established for diagnosis of AVM by dynamic and static... | 477,166 | [
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Presence of apolipoprotein-CII in commercially available albumin fractions. | 1. Commercially available bovine serum albumin as Cohn fraction V was demonstrated to contain small amounts of apolipoprotein-CII. 2. This apolipoprotein activated lipoprotein lipase in the same way as apolipoprotein-CII purified from human very-low-density lipoproteins. | 477,189 | [
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Structural and functional alterations in the mucosa of self-filling intestinal blind loops in rats. | 1. Self-filling blind loops of jejunum were constructed in three groups of rats; in the first, blind loops were created without further manipulation; in the second the bile was diverted permanently into the lower ileum below the blind loop, whereas in a third neomycin was added to the drinking water throughout the expe... | 477,194 | [
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The pattern of breathing in patients with chronic airflow obstruction. | 1. The pattern of breathing in 12 patients with severe irreversible airflow obstruction has been studied during ventilatory stimulation by rebreathing CO2. Mean maximum tidal volume response was only 1.23 +/- 0.30 litres (mean +/- SD); this represented 65% of mean measured vital capacity and 82% of mean measured inspir... | 477,204 | [
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A defect in zinc uptake by jejunal biopsies in acrodermatitis enteropathica. | 1. In a system in vitro, 65Zn accumulation by jejunal mucosal biopsies from patients with acrodermatitis enteropathica was found to be markedly reduced compared with controls. 2. We suggest that defective uptake of zinc by enterocytes is the primary abnormality responsible for the zinc deficiency underlying this disord... | 477,235 | [
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Accidental hypothermia and rewarming in dogs. | 1. Twenty lightly anaesthetized dogs were cooled to 29 degrees C by cold-water immersion. Ventilation was spontaneous and the animals were allowed to shiver freely. Metabolic heat production and respiratory heat exchange were measured during rewarming. 2. The animals were divided into four groups each of five dogs and ... | 477,241 | [
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Blood levels of medroxyprogesterone acetate after multiple injections of depoprovera or cycloprovera. | Mean levels of MPA in blood taken 90 days after injection were not significantly different between women who had received a single injection of DepoPrevera and those who had received eight injections at 90-day intervals. There was a wide variation in plasma MPA concentration in the two groups of women. In women who had... | 477,312 | [
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Cognitive impairment of aphasics in a colour-to-picture matching task. | Broca's and Wernicke's aphasics, non-aphasic brain-damaged patients and chronic schizophrenics were tested in a colour-to-picture matching task. For each of 42 black-and-white drawings of objects the most "typical" colour was to be selected from a set of 24 colour strips. Separate scores for the appropriateness of the ... | 477,339 | [
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Recovery from alexia without agraphia: report of an autopsy. | The patient is a 58-year-old Japanese teacher of German literature who suffered twice from cerebrovascular accidents, showing alexia without agraphia. Pathological examination showed an old infarct in the posterior two-thirds of the fusiform and almost the whole lingual gyrus, involving the posterior border of the para... | 477,344 | [
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0.3408079,
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0.1170455,
0.394729,
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0.1... |
Early childhood amnesia: a quantitative study with implications for the study of retrograde amnesia after brain injury. | Measurement of retrieval of episodic memories ascribed to the various years of early childhood was made over a three-month period of search by 17 normal young adults. The distribution of episodes ascribed to various ages is described, and it is shown that the recovery of memory from early childhood tends to show featur... | 477,348 | [
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Innovative adjuncts in hair transplantation. | After development of the technical, organizational, and esthetic phases, hair transplantation has progressed to a fourth stage. This is a comprehensive approach determined by the patient's degree of baldness and may require a combination of procedures to best correct the patient's defect. The punch autograft technique ... | 477,387 | [
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Molluscum contagiosum: the volcano phenomenon. | Molluscum contagiosum, a common cutaneous viral infection, responds to a variety of therapeutic modalities, but patient cooperation often limits the practitioner's choice. In an effort to provide minimally traumatic treatment for a four year old boy with this dermatosis, an interesting phenomenon was chanced upon, whic... | 477,390 | [
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Giant condyloma acuminatum. | The subtle histologic differences between condyloma acuminatum and giant condyloma acuminatum are presented in the following report. | 477,391 | [
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Doxapram hydrochloride: a respiratory stimulant for patients with primary alveolar hypoventilation. | Four patients (ages 43 to 51) with primary alveolar hypoventilation (PAH) syndrome were studied to characterize the pharmacologic augmentation of ventilation with intravenous doxapram hydrochloride. Doxapram hydrochloride evoked a rapid ventilatory increase of 50 to 100 percent in all four subjects with a consequent de... | 477,428 | [
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Adoption of Korean children by New York area couples: a preliminary study. | This paper reports on the first segment of a longitudinal study of the effects of transracial and transcultural transplantation into American families. | 477,455 | [
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[Topography and surgico-tactical principles of the mesocaval shunt]. | The mesocaval shunt has special advantages. It can be applied also in patient with worse condition (Child B and C). The technically simple performance according to the original method of Drapanas is recommended provided that anatomical variants at the surgical trunk of the vena mesenterica superior are known. The anato... | 477,468 | [
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The influence of clonidine on intraocular pressure. | In order to study the influence of clonidine on intraocular pressure (IOP), the drug was administered via different routes. The experiments were performed on chloralose-anaesthetized cats. The rise in IOP observed after administration of clonidine into the external carotid arteries was subjected to a pharmacological an... | 477,484 | [
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[Diagnosis of leucocytes in urine by means of a test-strip (author's transl)]. | A test-strip for diagnosing urinary leucocytes (Cytur) was evaluated by 11 centres, on a total of 1985 voided urine specimens. Results were compared with chamber counting of uncentrifuged urine, as well as by microscopic examination of spun sediment. With a reaction time of 15 minutes the test-strip compared well with ... | 477,520 | [
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[Local recurrences of carcinoma of the breast (author's transl)]. | Distant metastases were sought for in 90 patients with local recurrence of breast carcinoma. Only 11 patients had demonstrable spread of the disease at the time of referral. Two-thirds of all local recurrences presented within two years of the primary operation. In 66 out of 90 patients the recurrence was in the chest ... | 477,549 | [
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Individualisation of oral anticoagulant therapy. | The hepatic synthesis of vitamin K dependent coagulation factors is modified by oral anticoagulant drugs, resulting in the release of functionally deficient coagulation factors into the circulation and consequently anticoagulation. Since their introduction into clinical medicine over 30 years ago, both clinical and sci... | 477,573 | [
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Ether releases large amounts of prolactin from rat pituitaries previously "depleted" by short term suckling. | The effect of ether inhalation upon plasma PRL levels was assessed in lactating rats whose pituitary stores of the hormone first had been depleted by a short term (10-min) period of suckling in comparison with those whose PRL stores had not been depleted by prior suckling. Ether, unlike suckling or handling-decapitatio... | 477,601 | [
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The development of gonadotropin and steroid hormone patterns in male and female hamsters from birth to puberty. | Male (1--60 days old) and female (1--30 days old) hamsters were decapitated and serum levels of LH, FSH, PRL, progesterone, androgens (males), and estradiol (females) were measured by RIA. Males and females had similar levels of LH until 15 days of age and of FSH until 12 days of age, at which times gonadotropin levels... | 477,608 | [
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Effect of parathyroid hormone on the increase in serum glucose and insulin levels after a glucose load to thyroparathyroidectomized rats. | Thyroparathyroidectomy (TPTX) caused a significant increase in serum glucose and a corresponding fall in serum calcium in both fed and fasted rats. The increase in serum glucose, induced by TPTX, was markedly potentiated by a single intraperitoneal administration of calcium (2 mg/100 g BW) which caused a significant el... | 477,623 | [
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Kindling phenomenon: impairment by auditory stimuli. | By coupling kindling stimuli with tones, it is shown that kindled epileptiform activity is not easily classically conditioned such that it can be evoked by an auditory stimulus. On the contrary, a tone presented 400 msec before and during the kindling stimulus impedes the rate of kindling. | 477,629 | [
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Distinction between normal and epileptic rhythms in rodent sensorimotor cortex. | Characteristics of spontaneous spindling in electrocorticograms from awake rodents are described. Comparisons are made between this spontaneous activity and epileptic activity generated in the sensorimotor cortex. | 477,640 | [
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Do anticonvulsants reduce the efficacy of oral contraceptives? | Women in our area with epilepsy who were also taking oral contraceptives were identified. Of 82 patients taking oral contraceptives, 41 had used both anticonvulsants and oral contraceptives for a total of 955 months. Three documented oral contraceptive (pill) failures occurred during this period, whereas the expected n... | 477,641 | [
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Pseudohypoparathyroidism and epilepsy: diagnostic value of computerized cranial tomography. | Computerized cranial tomograms (CCTs) unexpectedly showed bilateral symmetrical calcifications in the basal ganglia and frontal areas in two unrelated epileptic patients 12 and 13 years of age. The patients presented with a variety of seizures, some with focal features; these seizures were resistant to medication in th... | 477,643 | [
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Effectiveness of clonazepan in startle-induced seizures. | Five cerebral-palsied children and adolescents with severe startle epilepsy became seizure-free after clonazepan was introduced into their existing anticonvulsant drug regimens. The drug was withdrawn in one case because of side effects. Two hemiparetic patients who had startle epilepsy as the only epileptic manifestat... | 477,644 | [
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Binding of Semliki Forest virus and its spike glycoproteins to cells. | We have studied the binding of the Semliki Forest virus and its isolated spike glycoproteins, in the form of water-soluble octameric complexes, to various cells at 5 degrees C. The number of viruses bound per cell increased strongly with increasing free concentrations of virus up to about 0.2 nM. At higher concentratio... | 477,669 | [
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1H-Nuclear magnetic-resonance studies on glycophorin and its carbohydrate-containing tryptic peptides. | The proton nuclear magnetic resonance (1H-NMR) spectra of glycophorin and its tryptic sialoglycopeptides were investigated. From the intensities of the assigned resonances it was concluded that all of the residues in the sialoglycopeptides are sufficiently mobile in conformation to give sharp resonances, while in glyco... | 477,674 | [
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A double-blind pediatric evaluation of levamisole in the prevention of recurrent upper respiratory tract infections. | Levamisole was tested double-blind in 106 children with recurrent upper respiratory tract infections. They received either levamisole (n = 53) or placebo (n = 53) 0.5 ml/kg bodyweight b.i.d. for two consecutive days each week for six months. A control examination was performed every two months. Both groups were compare... | 477,676 | [
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Pattern of growth hormone response to insulin, arginine and haemodialysis in uraemic children. | Plasma growth hormone (GH) concentrations after insulin and arginine stimulation were estimated in 11 dialyzed and 6 non-dialyzed children with chronic renal failure. Twenty healthy children served as controls. Plasma GH peak concentration and estimation of the total area under the plasma GH concentration-time curve by... | 477,677 | [
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Oral zinc sulphate as long-term treatment in Wilson's disease (hepatolenticular degeneration). | Clinical amelioration, clearance of Kayser-Fleischer rings and rising of ceruloplasmin concentration are described in a patient with the classical findings of Wilson's disease. These changes occurred during a 14-year period in which he used oral zinc sulphate (three times daily 200 mg) as the only medication to influen... | 477,692 | [
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Cooperative interactions at [3H]kainic acid binding sites in rat and human cerebellum. | Inhibition of the specific binding of [3H]kainic acid was studied in membranes isolated from rat and human cerebellum; the sequence of potencies in both species were: kainic acid greater than L-glutamic acid greater than dihydrokainic acid greater than D-glutamic acid. Whereas the Hill coefficient for unlabelled Kainat... | 477,725 | [
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Mechanism of the depressor response to dopamine in the rat treated with phenoxybenzamine. | Alterations of hypotensive responses to dopamine by antagonists were characterized in alpha-blocked, anaesthetized rats. Responses were not affected by d-propranolol (0.1 mg/kg) whereas d,1-propranolol (0.1 mg/kg) or haloperidol (1.0 mg/kg) attenuated them; higher doses of inhibitors (1.0 mg/kg; 5.0 mg/kg, respectively... | 477,731 | [
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0.09171578,
0.03452365... |
The role of fibroblastoid cells and macrophages from mouse bone marrow in the in vitro growth promotion of haemopoietic tumour cells. | Adherent cells from mouse bone marrow have been shown to promote the in vitro growth of the AVRij-1 tumour cell line. The experiments presented here suggest that the adherent cells involved in this phenomenon are the progeny of bone marrow derived fibroblastoid colony forming units. The latter were characterized by mea... | 477,770 | [
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Organization of the convergence in the intermediate cerebellar nuclei of somatosensory receptive fields with motor cortical-evoked responses. | The convergence in the intermediate cerebellar nuclei of somatosensory inputs with those from the motor cortex was investigated in cats (1) by examining with natural stimulation the receptive field of nuclear neurons, and (2) by determining the response of the same neurons to stimulation of motor cortical sites which h... | 477,778 | [
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-0.05029611,
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-0.1599033,
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-0.4847725,
0.07523122,
-0.1111365,
0.1282316,
0.2568201,
0.05755435,
0.1832387,... |
Cooperative neural processes involved in stereoscopic acuity. | Results of psychophysical experiments are reported showing that synchrony, appropriate relative placement, and absence of standing disparity are important conditions to be met by members of a target configuration if they are to participate in the cooperative neural processes leading to the best disparity discrimination... | 477,784 | [
-0.08429065,
0.03890109,
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0.02252708,
0.2955621,
0.2467958,
0.0... |
Inhibition of adrenalin depletion in hypoglycaemic rats following permanent adrenalin application by depot capsule. | Chronic treatment of rats with adrenalin by means of a subcutaneous depot capsule (cont. 40 mg dry adrenalin/HCl, Merck, ca. 10 mg ascorbic acid and ca. 0.4 ml 0.9% NaCl, and sealed with a dialysis membrane to provide constant adrenalin output) leads after a primary hyperglycaemic phase to hypoglycaemia. At the onset o... | 477,822 | [
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0.02937213,
0.2118386,
0.0303631,
0.03614876,
0.... |
Monosodium glutamate in the chick embryo: lack of obvious toxic or teratogenic effects when administered at 24 hours incubation. | The administration of monosodium glutamate (MSC) to chick embryos at 24 hours did neither produce gross developmental defects nor influence growth by 72 hours total incubation. The concentrations of MSG administered ranged from 0.3 to 46.6%, the volumes injected being 0.05, 0.1, or 0.2 ml. Several injection methods wer... | 477,823 | [
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0.1983459,
0.4459934,
0.33502,
0.1802026,
-... |
Effects of low doses of ochratoxin A after intratesticular injection in the rat. | The toxic effect of various doses of ochratoxin A on the rat testis was investigated after a single intratesticular injection. At time of sacrifice (day 10) degenerating changes occur in the testicular tissues: seminiferous tubules dilatation, cytolysis of the seminiferous epithelium, hyperplasia of the interstitial ti... | 477,844 | [
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0.04130488,
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0.3142336,
-0.02261746,
0.2405056,
0.5514763,
-0.02551681,
... |
125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures. | 125I-Insulin initially localizes to the plasma membrane of isolated rat hepatocytes but is subsequently internalized and preferentially associates with lysosomal structures. In the present study, we show that this preferential association to lysosomes occurs in regions of the cell rich in lysosomal and Golgi structures... | 477,850 | [
-0.02938844,
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0.06963744,
0.1805651,
0.2140409,
0.1645486,
0.1139568,
... |
Mitochondrial calcium efflux and porcine stress-susceptibility. | Mitchondrial Ca2+ efflux rates of M. longissimus dorsi correlate very closely with parameters associated with porcine stress-susceptibility. Experimental data support the measurement of mitochondrial Ca+2 efflux to be a very sensitive and reliable method for differentiating porcine stress-susceptibility. | 477,854 | [
-0.07640158,
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0.446163,
-0.02312758,
0.07461... |
A high molecular weight inhibitor of Ca2+ -dependent neutral protease in rat brain. | An endogenous, heat-stable inhibitor of high mol. wt (approximately 3x10(5)) was found to be present in rat brain, which inhibited Ca2+-dependent neutral protease specifically but not due to its binding of Ca2+ in the medium . | 477,856 | [
-0.1409864,
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... |
An actin-destabilizing factor is present in human plasma. | Plasma and serum of humans or experimental animals contain a factor which destabilizes F-actin. The factor has no DNAse or thrombin activity and after incubation with F-actin does not modify the position of the actin band on a SDS polyacrylamide gel. Hence it probably depolymerizes F-actin. | 477,868 | [
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0.... |
Effect of chronic hypo and hypervitaminosis C on the brush border enzymes and the intestinal uptake of glucose and alanine. | Brush border sucrase and alkaline phosphatase activities are considerably enhanced in the intestine of ascorbic acid deficient guinea-pigs. Similar increase in the uptake of D-glucose and L-alanine also occurs in chronic vitamin C deficiency. However the permeability of D-glucose and L-alanine in the intestine of anima... | 477,873 | [
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0.2471279,
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0.01873371,
0.02839293,
0.1274845,
0.005960213... |
Haemagglutinating activity of modeccin. | Modeccin, the toxin of Adenia digitata, agglutinates erythrocytes from several mammalian species. The haemagglutinating activity is enhanced by neuraminidase and is inhibited by galactose and by galactose-containing sugars. | 477,887 | [
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0.0521879,
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0.3810861,
0.02067487,
0.00634646... |
SEM surface morphology of the contractile cells in the rat seminiferous tubules. | The SEM observation of the basal surface of the contractile cells in the boundary tissue of the seminiferous tubule of the rat revealed that the contractile cells are extremely flat, vary in shape from rectangular to hexagonal, and are arranged close to each other, in the fashion of a tiled floor, around the seminifero... | 477,892 | [
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... |
Monitoring of the dilution rate during continuous in vivo blood sampling with a double lumen catheter. | A simple and non-destructive method for monitoring the dilution rate during continuous blood sampling is described. When the dilution rate is not constant, the proposed method based on electrical resistivity measurement provides a correction factor for further analysis. | 477,904 | [
0.03500513,
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0.... |
[Renal potassium excretion in rats exposed to different carbohydrate metabolism treatments]. | After administration of 5 ml/100 g of 1.25% KCl solution into the rat stomach, the excretion of potassium in urine was 529.7 +/- 19.4 mueq/100 g.4 hours. After the same amount of potassium in 1--10% solutions, 2% solution of fructose, or 2% solution of mannitol, the potassium excretion reduced by over 25%. Glucose exer... | 478,021 | [
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0.1636877,
0.3529891,
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-0.002357298,
... |
Role of macrophages in intraepidermic vesiculation in pemphigus vulgaris. Electron-microscopic observations. | The authors made an electron-microscopic observation of intraepidermic vesiculation in pemphigus vulgaris at its early stage, and found that numerous macrophages were invading the cleft located immediately superior to the basal cell layer. They suggest that the formation of cleft, as a preceding stage to the eventual d... | 478,051 | [
0.07129303,
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0.1046749,
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0.07093333,
0.4086859,
0.0071962... |
Epidermal hyperplasia induced in guinea pig flank skin by intradermal injection of Sudan red. | Studies of dermal-epidermal interactions were conducted with guinea pig flank skin and intradermal injections of the irritant, Sudan IV dye in olive oil. These injections led to epidermal hyperplasia in areas overlying the irritant and the effect was most significant when the irritant was placed in the upper dermis. Ba... | 478,068 | [
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0.2697237,
0.2440024,
0.5094194,
-0.09392775,
... |
Keratosis follicularis and familial benign chronic pemphigus in the same patient. | A case is described with features both of Hailey-Hailey and Darier's disease in a male patient who presented skin lesions since he was 8 years old. The present case is discussed in relation to data obtained from the literature, and a differential diagnosis from Grover's disease is made. | 478,073 | [
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... |
Fluorescein angiography in borderline diabetics. | Fluorescein angiography was performed in twenty three men with impaired oral glucose tolerance (borderline diabetics) and sixteen matched, normoglycaemic controls. Retinal abnormalities (microaneurysms and leakage of dye) were observed in 18.7% of the controls, 41.6% of sustained borderline diabetics and 54.4% of initi... | 478,088 | [
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0.1322828,
0.09582195,
0.2903... |
Retinal fluorescein angiography and hemoglobin A1C in borderline diabetes. | In a controlled study fluorescein angiography of the retina and measurements of hemoglobin A1C were carried out in subjects with slightly abnormal two-hour glucose tolerance and controls with normal glucose tolerance. Fluorescent dots were present in 50 per cent of the series with a reduced glucose tolerance. Leakage f... | 478,089 | [
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0.1091792,
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0.08949781,
0.190065,
0.3215722,
0.3232555,
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Netilmicin: clinical evaluation of efficacy and toxicity of a new aminoglycoside. | The efficacy and toxicity of netilmicin, a new semisynthetic aminoglycoside, was clinically evaluated in fifty-two patients with moderate to severe infections with Gram-negative rods or Staph. aureus. Average duration of treatment was 14 days and mean total dose 2,960 mg. One-hour mean value of netilmicin serum concent... | 478,159 | [
-0.3158102,
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0.3087241,
0.1548553,
0.2811261,
0.3993535,
... |
Domperidone in the treatment of dyspepsia: a double-blind placebo-controlled study. | Domperidone, at a dosage of 20 mg t.d.s before meals, in a double-blind, crossover, placebo-controlled trial reduced the level of the symptoms of dyspepsia by 76% compared to a 16% reduction with placebo. This difference was statistically significant (p less than 0.001). Thirteen of the fourteen patients in the study p... | 478,162 | [
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0.191344,
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... |
The effects of preparturient avoidance conditioning on postnatal caretaker behavior and offspring catecholamine levels and behavior in C57BL/6J mice. | Avoidance conditioning during pregnancy, changes in caretaker behavior during lactation, and changes in offspring catecholamine levels and behavior were investigated in C57BL/6J mice. Three equal groups of mice were employed. One group was avoidance conditioned prior to pregnancy and continued to avoid shock during pre... | 478,176 | [
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0.08643275,
0.05821377,
-0.1093188,
-... |
Effect of a feeding schedule on crypt cell proliferation in the small intestine of the rat. | Using a stathmokinetic technique, the mitotic rate in the small intestinal crypts of two groups of male Sprague-Dawley rats was studied. The first group was fed solids for 3 h daily only. The second group was fed solids ad libitum. In the first group it was found that the mean daily weight of food consumed rose quickly... | 478,191 | [
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0.2403089,
0.2089992,
-0.023312... |
Study of parotid and mixed saliva in the diagnosis of chronic pancreatitis. | A study on the diagnostic value of the parotid and mixed saliva assay after stimulation with 1% pilocarpine hydrochloride was carried out in 36 controls and 26 patients affected with chronic pancreatitis. No statistical difference between the two groups was found as far as saliva volume, bicarbonate and amylase (concen... | 478,198 | [
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0.03951636,
0.2455953,
-0.3544173,
0.148098... |
Abnormalities of jejunal mucosal enzymes in ulcerative colitis and Crohn's disease. | Jejunal mucosal function and structure was examined in 31 patients with ulcerative colitis and 29 patients with Crohn's disease with ileal, ileocolonic or colonic involvement; A significant reduction of the specific activity of disaccharidases (lactase, sucrase and trehalase) in jejunal mucosal homogenate occurred in p... | 478,207 | [
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0.2963101,
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0.04727819,
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Developmental capacity of aneuploid Xenopus species hybrids. | Diploid as well as triploid Xenopus interspecific hybrids generate aneuploid eggs because of the presence, at meiosis, of univalent chromosomes which are presumably distributed at random. Zygotes obtained from such eggs, fertilized by either normal or UV-irradiated sperm, were analysed for their developmental capacitie... | 478,210 | [
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0.3625638,
0.283451,
-0.1095417,
-... |
Regeneration of vitamin A deficient rat tracheal epithelium after mild mechanical injury. Growth kinetics and cellular differentiation. | Mild mechanical abrasion of tracheal epithelium of Vitamin A deficient rats removed the superficial cells and spared basal cells which divided to repopulate the damaged area. The proliferative cells passed through a period of DNA synthesis with the greatest numbers of thymidine incorporating cells in samples labelled 2... | 478,213 | [
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0.08903726,
-0.1044727... |
[Quantitative analysis of sister chromatid exchanges in the cell]. | Assuming a random nature of distribution of sister chromatid exchanges (SCE) in a karyotype, the formulae have been obtained allowing the calculation of the number of SCE that are overlooked because of a limited resolving power of the SCE detection method. The results obtained mean that the actual number of SCE is more... | 478,287 | [
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0.3160622,
0.49561,
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0.05262855,
... |
[Correlation of heredity and environmental factors in the etiology of Vilyui encephalomyelitis. I. Patient frequency in families]. | Viljuisk encephalomyelitis (VE) is a severe neurologic disease characterized by slow progressive dementia', oligobradykinesia, low spastic paraparesis and speech disturbances. It develops in persons of 20-50 years old. VE occurs in a small region of middle Viljui, but for last years the focus has considerably expanded.... | 478,288 | [
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0.04545506,
0.3691556,
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-0.6193084,
0.258702,
-0.04851316,
0.0474364,
0.005279219,
0.09352947,
-0.08079438... |
A 10-year follow-up study of 97 epileptics. | 1) Of 267 patients with epilepsy who were examined in our clinic during the period between 1964 and 1966, 97 were investigated in a 10-year follow-up study. The patients were selected according to the following criteria: the age of onset of seizures was 10 years or older and the follow-up period was 10 years after the ... | 478,391 | [
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... |
Private-sector services for low-income psychiatric outpatients. D.C. Institute of Mental Hygiene Washington, D.C. | A community-based, nonprofit outpatient clinic in Washington, D.C., has been successful in using the medical model to provide high-quality services to low-income patients. In 13 years it has grown from five staff members and 17 patients to a part-time staff of 74 and a patient population of 1500. Hours of direct servic... | 478,451 | [
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New reporting system aids epidemiologists. | The feedback loop reporting system lifts the burden of reporting communicable diseases from the physician's shoulders and ensures more efficient, and more frequent, reporting. | 478,457 | [
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Hypertension clinic proves effective. | Hypertension can best be combatted through patient education and early detection. A screening clinic can be an excellent way of reaching the public if follow-up is diligent. | 478,477 | [
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Chromosome lesions in amniotic fluid cell cultures. | The frequencies of chromosome lesions were determined on 3537 mitoses in samples of varying sizes from cultures of 25 amniotic fluid specimens taken from patients at cytogenetic risk. The average percentage values of aberrant cells, including and excluding gaps, were 12.5 and 4.9, respectively. The corresponding values... | 478,539 | [
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0.04582529,
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Normal human endometrium in cell culture. II. A microspectrophotometric study of polyploid nuclei in short-term primary epithelial cultures. | The growth of short-term primary cultures of endometrial epithelium has been studied using Feulgen microspectrophotometry. A gradual increase in the number of polyploid nuclei up to 64C has been observed and is associated with a decline in the growth capacity of the cultures. The specific mechanism(s) of this polyploid... | 478,565 | [
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Acute induction of joint inflammation in the rat by poly I . poly C. | Intraarticular injection of interferon inducer, double-stranded polyinosinate-polycytidylate (Poly I . C) caused acute synovitis in rats. This acute inflammatory response was accompanied by an increased concentration of prostaglandin E (PGE) in the synovial tissue. Double-stranded polyadenylate-polyuridylate (Poly A . ... | 478,595 | [
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0.3338965,
0.08696522,
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Bone healing in rabbits after compression osteosynthesis: a comparative study between the radiological and histological findings. | The relationship between the radiological and histological findings was studied in a series of rabbit osteotomies and fractures stabilized with plates with and without longitudinal compression. When compression was employed, the gap varied between 10 and 200 micrometers and no radiologically visible callus was seen. Af... | 478,620 | [
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Purification and characterization of Clostridium difficile toxin. | Recent evidence indicates that toxigenic Clostridium difficile strains are a major cause of antimicrobial-associated ileocecitis in laboratory animals and pseudomembranous colitis in humans. C. difficile ATCC 9689 was cultivated in a synthetic medium to which 3% ultrafiltrated proteose peptone was added. Purification o... | 478,634 | [
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0.2540098,
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0.1876938,
-0.05154473... |
Immunosuppression and isolation of rubella virus from human lymphocytes after vaccination with two rubella vaccines. | Two groups of young rubella-susceptible women were vaccinated with two rubella vaccines. Heparinized blood samples were taken from all individuals the day of vaccination and 5, 7, 15, 21, 30, 35, and 42 days later. Purified lymphocytes from these samples were cocultivated with AGMK cells for rubella virus isolation. Pa... | 478,639 | [
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0.033572,
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0.1181982,
0.1103629,
0.1906551,
0.3753047,
0.04182807,
0.100909,
0.0... |
The application of robust non-linear regression methods for fitting hyperbolic Scatchard plots. | The Scatchard plot is an essential tool for the estimation of binding parameters in biochemistry. In certain situations the fitting of a hyperbolic line is required in this context. It is proposed to solve this non-linear regression problem by robust methods. A method according to Huber and Dutter (1974) is outlined an... | 478,689 | [
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0.1967486,
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... |
Drug abuse, hopelessness, and suicidal behavior. | This study focused on assessing variables which may differentiate suicidal drug abusers from nonabusers. Data from a sample of drug abusing (n = 86) and nonabusing (n = 298) suicide attempters were subjected to a stepwise multiple regression analysis to identify factors related to suicidal intent. The analysis revealed... | 478,694 | [
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0.1660611,
0.115392,
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0.07482462,
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0.05243835,
-... |
A socialization program for chronic alcoholics. | The staff of a court-mandated treatment program for convicted drunk drivers set up an alternative socialization program for chronic alcoholics who failed to respond to the defense-reductive strategies employed in their general program. No attempt was made to deal directly with long-standing underlying problems; rather ... | 478,711 | [
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0.4996396,
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0.06755489,
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0.01391001,
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0.1995395,... |
Exploration of a live-together-group-together paradigm with incarcerated drug offenders. | Prisoners who both participated in biweekly, biracial therapy groups and lived together in large cubicles were compared with prisoners who grouped but did not live together. Results suggested: (1) greater group cohesion among inmates who lived and grouped together, (2) greater acceptance of Blacks by Whites exposed to ... | 478,715 | [
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0.4294491,
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0.3379785,
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0.1134246,
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0.1865847,
0.1030... |
Psychoanalytical studies on the causes of intoxication by marijuana. | The study of 27 illegal users of marijuana, through psychoanalysis and analytical group psychotherapy and through psychiatric examinations, made it possible to discover that these patients felt their parents to be aggressive or indifferent or unaffectionate or absent (among the parents of different temperaments, and co... | 478,717 | [
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0.248888,
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0.1269687,
0.09085732,
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0.2875072,
0.1583121,
0.1570756,
0.3323966,
0.2582071,
-0.107642,
0.019744... |
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