title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Further identification of neurons in the abdominal ganglion of Aplysia using behavioral criteria. | This review is an updating of the paper by Frazier et at. 13 in which 30 individual cells and 8 cell clusters were identified in the abdominal ganglion of of Aplysia californica on the basis of morphological, physiological and pharmacological criteria. Since that time, a number of neurobiological studies have utilized ... | 832,146 | [
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A comparison of etidocaine and lidocaine in epidural analgesia for surgery. | Etidocaine 1 per cent has been compared with lidocaine 2 per cent for epidural anaesthesia for surgery. Etidocaine produced a block which was characteristically longer, with a more profound motor component than lidocaine. The quality of anaesthesia was not as satisfactory with etidocaine and the danger of inadvertent i... | 832,182 | [
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Effects of immune-mediated enteroluminal neltrophil emigration on intestinal function in pigs. | Intestinal function was assessed in cannulated loops of porcine proximal jejunum during immune-mediated emigration of neutrophils into the intestine. Net water, net sodium, net chloride, undirectional sodium and unidirectional chloride fluxes were measured before and after intestinal exposure to an antigen in both sens... | 832,187 | [
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Spontaneous aortocaval fistula secondary to ruptured abdominal aortic aneurysm. | Two patients with the rare condition of spontaneous aortocaval fistula secondary to ruptured abdominal aortic aneurysm were treated successfully by surgical closure of the fistula. In view of the existing controversies on certain aspects of the pathophysiology involved, canine experiments were performed to elucidate th... | 832,201 | [
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Purpura associated with hypergammaglobulinemia, renal tubular acidosis and osteomalacia. | Two patients with hyperglobulinemia associated with purpura were studied. One had features of Sjögren's syndrome, while the other appeared to have a primary condition -- "chronic benign purpura". Both patients also had renal tubular acidosis, osteomalacia and renal calculi, with disturbed calcium metabolism and acid-ba... | 832,220 | [
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Colorectal polyps and carcinoma in Southern Iran. | A study was made of the prevalence of colorectal polyps (excluding juvenile polyps, familial polyposis coli and villous adenomas) and the minimum frequency of colorectal carcinoma in Southern Iran. A total of 801 large intestines from necropsies performed on individuals 20 years or older was examined with or without ma... | 832,242 | [
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Desmoplastic malignant melanoma: a report on two additional cases. | Two cases of desmoplastic malignant melanoma are described, bringing the total reported to nine. The first developed in a lentigo maligna melanoma and contains the seed of its local recurrence in the primary lesion. The second developed in a clinically apparent congenital nevus and unites the histologic features of the... | 832,243 | [
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Effect of Ca2+ and salt on forms of estradiol cytoplasmic receptor in human neoplastic breast tissue. | After incubation with [3H]estradiol low-salt sucrose gradient centrifugation of 250 human breast tumor cytosis demonstrated receptor-bound steroid in both 4 S and 8 S forms. Cytosols prepared from 24 of these receptor-positive tumors were examined in the presence of KCl, Ca2+ and the serine protease inhibitor, phenylme... | 832,263 | [
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Inhibition of DNA polymerase from L1210 murine leukemia by a sulfhydryl reagent from agaricus bisporus. | The 490 quinone, a natural sulfhydryl-arylating reagent from the mushroom, Agaricus bisporus, markedly inhibited L1210 murine leukemia DNA polymerase alpha while resulting in little inhibition of DNA polymerase beta from this source. This quinone was more strongly inhibitory than p-chloromercuri-benzoate or N-ethylmale... | 832,267 | [
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Effect of a high-beef diet on the fecal bacterial flora of humans. | Ten human volunteers completed a 4-month diet series consisting of 1 month each of a control diet, a meatless diet, a high-beef diet, and the same control diet. Fat and fiber contents were essentially the same in all four diets, but protein content was doubled during the high-beef diet. During the 4th week on each diet... | 832,279 | [
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Catechol-mediated effects of harmaline on the action potential of rat atrial fibres. | The mechanism of the transient enhancement of the amplitude of the action potential (AAP) induced by harmaline (HME) was studied in rat atria. The results show that HME increases AAP through an enhancement of the slow component responsible for the last part of the upstroke, which overcomes an inhibitory action on the i... | 832,285 | [
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Post implantation viability in canine allograft heart valves. | Known viable allograft canine pulmonary valves were inserted in an isotopic position ensuring normal physiological function and simulating the clinical situation. Valves removed at periods up to eight weeks were assessed for viability using previously established criteria of tissue culture and protein and collagen synt... | 832,290 | [
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Intestinal enzymes activities in isolated villus and crypt cells during postnatal development of the rat. | A modification of Weiser's (1973) cell isolation method was used in order to study the developmental pattern of various intestinal enzyme activities in villus and crypt cells of normal rats from 5 days after birth until 8 weeks. Alkaline phosphatase and enterokinase activities were always located in the upper villus zo... | 832,293 | [
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The morphology of erythroid cells separated by density gradient centrifugation through Ficoll. | The regenerating blood of geese injected with phenylhydrazine was subjected to large scale, zonal centrifugation through density gradients of Ficoll. In this way, erythroid cells were fractionated according to their respective stages of development. Highly enriched fractions were obtained, containing cells that were we... | 832,304 | [
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A scanning electron microscope study of the microvasculature of the avian lung. | 1. The microvasculature of the lung of the duck and pigeon was studied by scanning electron microscopy of vascular casts and critical point dried preparations of the gas exchange tissue. 2. The gas-exchange cappilaries are discrete tubular vessels intimately associated with air capillaries in a three dimensional networ... | 832,311 | [
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The relationship between the metabolism of procainamide and sulfamethazine. | The metabolism of sulfamethazine (SMZ), which is acetylated by a binodally distributed enzyme, and procainamide (PA) was compared in 21 normal volunteers, each given a single oral dosted metabolites, N-acetyl-procainamide (NAPA) and Ac-SMZ, were measured. Subjects with less than 64% Ac-SMZ in the 0-8 hour collection we... | 832,354 | [
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Quantitative alkaline phosphatase isoenzyme determination by electrophoresis on cellulose acetate membranes. | We present a new method for quantitative determination of alkaline phosphatase isoenzymes. This method consists of electrophoretic separation on cellulose acetate membranes, special fixation technique to avoid elution and diffusion of enzyme protein during incubation, specific staining, and quantitative evaluation by d... | 832,369 | [
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New approach to determination of total ketone bodies in serum. | We describe a one-step assay for total ketone bodies in serum. D-BETA-Hydroxybutyrate is enzymatically oxidized by NAD+ to acetoacetate. This thermodynamically unfavorable reaction is driven to completion by coupling it with the enzymatic reduction of pyruvate by NADH. The acetoacetate so formed, as well as the pre-exi... | 832,372 | [
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Glyceraldehyde-phosphate dehydrogenase (total and isoenzyme activity) in the early diagnosis of myocardial infarction. | Enzyme "panels," in which creatine kinase and lactate dehydrogenase activities in serum are measured, are useful indicators of myocardial infarction. We examined a further enzyme, glyceraldehyde-phosphate dehydrogenase (EC 1.2.1.12), by comparison with creatine kinase (EC 2.7.3.2), in the early diagnosis of such infar... | 832,386 | [
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History and background of protoporphyrin testing. | Lead intoxication was first associated with increased coproporphyrin excretion almost 100 years ago; but not until the 1930's were abnormalities in blood protoporphyrin detected. These later findings have been interpreted as an inhibition by lead of iron incorporation into protoporphyrin during heme synthesis. The test... | 832,388 | [
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The hematofluorometer. | A portable filter fluorometer, the hematofluorometer--which utilizes "front face" optics, internal standards, and digital computation capabilities--has been specifically designed for the rapid (approximately 5 s) assay of erythrocyte zinc protoporphyrin in unprocessed blood. A small (unmeasured) drop of blood, such as ... | 832,391 | [
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Fluorometric estimation of triglycerides in serum by a modification of the method of Bucolo and David. | An enzymic, flurometric method is described for determination of triglycerides (and glycerol) in blood serum, a modification of the method of Bucolo and David [Clin. Chem. 19, 476 (1973)]. Commercially available reagent kits are used. The rate of disappearance of NADH fluorescence at 460 nm (excitation wavelength, 365 ... | 832,396 | [
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Porphyrin synthesis in blood cells of patients with erythropoietic protoporphyria. | The protoporphyrin accumulation observed in the red blood cells of patients with erythropoietic protoporphyria can be explained by decreased activity of the enzyme heme synthetase or by increased production of porphyrins in the affected cells. In literature experimental evidence both for a partial heme synthetase defic... | 832,411 | [
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Activities of purine pathway enzymes in gouty human fibroblasts aged in vitro. | The finite life-span of fibroblasts in culture may reflect aging at the cellular level and gout is clinical condition whose incidence also increases with age. In order to better understand the age-related changes in purine metabolism, activities of purine degrading (adenosine deaminase and 5'-nucleotidase) and reutiliz... | 832,427 | [
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Harbingers of paroxysmal ventricular tachycardia in acute myocardial infarction. | We examined the harbingers of 68 episodes of paroxysmal ventricular tachycardia in 42 patients with documented acute myocardial infarction. Late ventricular premature contractions initiated 46 bouts of paroxysmal ventricular tachycardia, while 17 were engendered by early ventricular premature contractions and five by a... | 832,482 | [
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Mural endocarditis associated with recurrent false aneurysm of the left ventricle. | Acute bacterial endocarditis developed in a 65-year-old man two years after surgical resection of a false aneurysm of the left ventricle. The patient had cerebral embolic manifestations, and coagulase-positive Staphylococcus aureus was cultured from each of six blood samples. A pericardial friction rub and a changing p... | 832,500 | [
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Treatment of typhoid fever with fosfomycin alone and associated to chloramphenicol or ampicillin. | Treatment with fosfomycin alone and associated to subtherapeutic doses of chloramphenicol or of ampicillin, has been tried on 50 patients with typhoid fever and on four carriers of S. typhi in the Hospital del Rey. 15 patients were treated with fosfomycin alone, 22 with fosfomycin plus chloramphenicol and 13 with fosfo... | 832,538 | [
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The cause and treatment of idiopathic pruritus ani. | Six common foods can cause the clinical entity called "idiopathic" pruritus ani. They are coffee, tea, cola, beer, chocolate, and tomatoes. Pruritus ani occurs in 24 to 48 hours when a patient consumers more than a threshold amount of one or more of these foods and disappears spontaneously in a few days provided the th... | 832,560 | [
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0.4304713,
-0.178224... |
[Desquamating intersitial pneumonia (author's transl)]. | A rare case of desquamating interstitial pneumonia, in a 15-year-old boy, is reported. Symptoms consisted of dry cough, progressive dyspnoea and chest pain. The chest X-ray revealed bilateral basal opacities. There were hypoxaemia and restrictive ventilatory changes. Bacteriological, virological and serological tests w... | 832,583 | [
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... |
[Preliminary results of preoperative radiotherapy in carcinoma of the rectum (author's transl)]. | Preliminary results were evaluated in patients with carcinoma of the rectum of whom 33 had preoperative radiotherapy and 23 were treated by operation only. The tumour stage was T2-4 NX MO in all patients. There was no significant difference between the groups as to postoperative mortality, would healing, and postoperat... | 832,607 | [
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Catecholaminergic involvement in the effects of amphetamine isomers on seizure susceptibility. | The (+)-amphetamine (2.5 mg/kg) increase in pentylenetetrazol seizure was abolished by pretreatment with reserpine, alpha-methyltyrosine methyl ester (alpha-MT), FLA-63 or 6-hydroxydopa. All treatments except reserpine antagonized the increase in seizure threshold produced by (-)-amphetamine (4 mg/kg). Only reserpine +... | 832,677 | [
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The role of the psychiatrist in a reproductive biology clinic. | The psychiatrist consulting to an infertility clinic is confronted with a variety of clinical issues and problems. The couple arrives with anxiety, for a work-up that in itself will be traumatic. The psychiatrist's role is to weed out distortions and issues that are unreal. Psychosexual and marital conflicts may also m... | 832,724 | [
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In vivo sodium, potassium, and sperm concentrations in the rat epididymis. | In vivo samples of epididymal fluids were obtained through the use of micropuncture techniques. Microsamples from four areas of the rat epididymis were analyzed for Na+ and K+ concentrations and for sperm density. Na+ values declined significantly from caput to corpus epididymidis (P less than 0.01), while K+ and sperm... | 832,732 | [
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Study of an epidemic of jaundice, presumably due to toxic hepatitis, in Northwest India. | An epidemic of jaundice probably due to toxic hepatitis occurred in three adjoining districts of Northwest India during the period November and December, 1974. The dogs of the villages were affected first, then the human beings. Detailed clinical features, appropriate laboratory tests, and liver biopsies were studied. ... | 832,797 | [
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Determination of molecular weight, isoelectric point, and glycoprotein moiety for the principal skin test-reactive component of histoplasmin. | A purified component designated HPD (histoplasmin-purified derivative) dII was isolated from two different cru-e histoplasmin lots by a combination of gel filtration and polyacrylamide disc electrophoresis (Sprouse, 1969). A 0.05-mug portion of HPD dII was reactive and specific in detection of delayed hypersensitivity ... | 832,901 | [
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The determination of the diffusion coefficient of krypton in rabbit ocular tissue. | The validity of the inert gas clearance method for measuring choroidal blood flow has recently been demonstrated by studying the diffusion of krypton in ocular tissue. In this study the diffusion coefficients of krypton in rabbit ocular tissue were calculated from measurements of the diffusion coefficients of xenon. Th... | 832,969 | [
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Blue and green cone mechanisms in retinitis pigmentosa. | Pronounced abnormalities in the increment threshold curves for the blue and green cone mechanisms only 10 degrees above the fovea, and in some cases in the fovea as well, have been found with a 2.5 degrees stimulus in different genetic types of retinitis pigmentosa. Whenever cone thresholds were abnormal, thresholds de... | 832,975 | [
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Consecutive demonstration of nerves containing catecholamine and acetylcholinesterase in the rat cornea. | The innervation of the cornea of newborn (two day old) and adult rats was investigated using glyoxylic-acid-induced fluorescence (GIF) for catacholamines and subsequent acetylcholinesterase reaction. Fluorescent nerve were observed around the limbal vessels and in the pericorneal nerve plexus, from which they branched ... | 833,015 | [
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Navicular disease in the horse: risk factors, radiographic changes, and response to therapy. | In a retrospective study, 74 horses met defined historical and clinical features indicative of navicular disease. Most of the affected horses were 4 to 9 years old. Males had a greater risk of navicular disease than females, geldings had a greater risk than stallions, and Quarter Horses had a greater risk than other br... | 833,042 | [
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... |
Selective immunoglobulin M deficiency in foals. | Selective immunoglobulin M deficiency was diagnosed in 5 foals, on the basis of reduced serum immunoglobulin M concentrations (more than 2 standard deviations below the normal mean). All 5 foals had clinical signs or lesions involving the respiratory tract. Lkebsiella sp was isolated from joint fluids, bronchial lymph ... | 833,046 | [
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High performance liquid chromatographic analysis of supplemental vitamin E in feed. | Supplemental vitamin E is extracted from feed in one step with methanol and analyzed by reverse phase partition chromatography in less than 10 min, using isocratic elution with either methanol or water-methanol as the mobile phase. Detection response (as measured by peak area) was linear between 0.5 and 3.0 mug, and th... | 833,088 | [
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Electron impact and chemical ionization mass spectrometry of some butyrophenones. | The mass spectra of some butyrophenones are presented. Electron impact ionization and chemical ionization with isobutane as the reagent gas are compared. The chemical ionization spectra show the quasi molecular ion (M + H)+ to be the most abundant ion. Important fragments in the electron impact spectra are discussed fo... | 833,097 | [
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Separation and ultraviolet absorbance techniques for determining dihydrotachysterol in pharmaceutical preparations. | Three separation techniques and ultraviolet (UV) spectrophotometry are described for dihydrotachysterol (DHT). The absorbance procedure eliminates the necessity of establishing a regular baseline, which is advantageous in certain cases. The relative absorbance values obey Beer's law in the range of 1-10 mug DHT/ml etha... | 833,103 | [
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Nucleotide polymerases in the developing avian erythrocyte. | Avian erythroid cells were separated into five developmental stages by sedimentation on discontinuous isotonic albumin gradients. Solubilized enzyme activities from whole cells were partially purified and characterized by ion exchange and ion filtration chromatography and velocity sedimenttation analysis. Three nucleot... | 833,121 | [
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Studies on the kinetic mechanism of oxidative phosphorylation. | The kinetics of the synthesis of ATP from ADP and Pi by beef heart submitochondrial particles were examined. When Pi was the variable substrate positive cooperativity was observed, whereas if ADP was varied, linear double reciprocal plots were obtained. The analog of Pi, thiophosphate, was a noncompetitive inhibitor of... | 833,136 | [
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Specificity of fructose-1, 6-P2 aldolase (muscle) and partition of the enzyme among catalytic intermediates in the steady state. | Others have concluded that beta-fructose 1, 6-bisphosphate is a substrate for muscle aldolase on the basis of rapid kinetic measurements. In view of new data showing excellent aldol cleavage of an analog of the keto form and a very high rate of spontaneous ring opening, Midelfort et al. (Midelfort, C. F., Gupta, R., an... | 833,139 | [
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Topography of the external surface of the human red blood cell membrane studied with a nonpenetrating label, [125I]diazodiiodosulfanilic acid. | The topography of the external surface of the human red cell membrane has been studied using an impermeant radioactive probe, [125I]diazodiiodosulfanilic acid, which binds covalently to protein groups of the membrane following reaction with intact cells. The pattern of labeling was assessed by sodium dodecyl sulfate-po... | 833,150 | [
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Use of the spiral coil membrane oxygenator during open heart surgery in infants and children. | The spiral coil membrane oxygenator was used without an arterial line filter during short term total cardiopulmonary bypass in 50 infants and children. The compact oxygenator proved to be efficient and reliable, was easy to operate in a simple perfusion circuit, has a high flow rate to priming volume ratio and eliminat... | 833,185 | [
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Scanning-electron-microscopic and functional studies of oxygenator-membranes during long-term-perfusion. | Various types and amount of deposits were noted on the surface of different membrane oxygenators during experimental long-term perfusion in sheep studied by SEM. They were present in spite of adequate heparinization. The deposition of blood material suggests, that the imperfection of the membranes by fabrication must b... | 833,189 | [
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Congenital arteriovenous fistula of the internal mammary vessels: report of a case and review of the literature. | The case of a congenital arteriovenous fistula of the internal mammary vessels in a 41 year-old woman has been reported, and the pertinent literature briefly reviewed. These rare lesions may become apparent only relatively late in life. The accompanyiny signs are often misleading. In view of the uncertain long-term out... | 833,196 | [
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Subcellular localization of a cytochrome P-450-dependent monogenase in vesicles of the higher plant Catharanthus roseus. | The intracellular location of a cytochrome P-450-dependent monoterpene hydroxylase from the higher plant, Catharanthus roseus, has been investigated. By differential and sucrose density gradient centrifugation, utilizing marker enzymes and electron microscopy, the monooxygenase was demonstrated to be associated with ve... | 833,200 | [
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Distribution of anionic sites on the oviduct ciliary membrane. | Polycationic ferritin (PCF) was used as a visual probe for anionic sites on the oviduct ciliary membrane. The binding of PCF to ciliary membranes was dependent on the concentration of the probe in the incubation media. At low concentrations (0.08-0.16 mg/ml), PCF was bound exclusively to the tip of the cilium whereas a... | 833,205 | [
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... |
An in situ fluorimetric method for the detection and quantitative analysis of fenitrothion, its breakdown products and other amine-generating compounds. | A procedure is described for the in situ detection of primary amine-generating pesticides on thin layers of silica gel. The technique is based on the reaction of fluorescamine with primary amines to yield highly fluorescent derivatives. Nitro compounds are first reduced to their corresponding primary amines. Pesticides... | 833,240 | [
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... |
Demonstration of a specific serum carrier protein of nonsuppressible insulin-like activity in vivo. | The fate of nonsuppressible insulin-like activity (NSILA-S) was studied by injecting a tracer of 125I-NSILA-S iv into rats. Ten minutes after injection of 125I-NSILA-S alone, 20% of the label is found in serum, whereas after the injection of 125-I-insulin or 125I-NSILA-S together with an excess of cold NSILA-S only 8% ... | 833,254 | [
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L-Dopa stimulated growth hormone release in the blind. | Following L-Dopa administration (single oral dose of 500 mg), plasma Growth hormone (GH) levels significantly rose in 7 out of 8 normal subjects (aged between 64-83) and in 4 out of 8 blind subjects (aged between 60-88). The mean peak +/- SE in the 8 normal subjects was 24.9 +/- 4.9 ng/ml and in the 8 blind subjects wa... | 833,257 | [
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The effect of dopamine infusion on insulin and glucagon secretion in man. | The effect of dopamine on the release of insulin and glucagon was investigated in eight adult subjects. Dopamine infused iv at a rate of 4 mug/kg/min X 2 hr, unaccompanied by cardiovascular changes, induced a prompt and significant increase in plasma insulin and glucagon and in plasma glucose levels. These findings sug... | 833,258 | [
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The effect of osmotic stimuli on prolactin secretion and renal water excretion in normal man and in chronic hyperprolactinemia. | An osmoregulatory role for prolactin (PRL) in man has been postulated, and PRL secretion has been reported to be influenced by osmotic stimuli. Clinical observation, however, does not support this notion. The effects of water loading, hypertonic saline infusion and nicotine on serum PRL and on renal water metabolism we... | 833,259 | [
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Wall-less microbial isolate from a human renal biopsy. | An orgainsm was isolated from a kidney biopsy of a patient with renal failure. Electron microscopy revealed an ultrastructure very similar to that of a bacterial L-form or mycoplasma. But macroscopically, its colonial morphology was unusual and distinct from that ascribed to these wall-less organisms. This isolate lack... | 833,264 | [
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Rheumatoid factor: a cause of fals positive histoplasmin latex agglutination. | Ten of thirteen patients with positive histolatex agglutination titers of 1:32 or greater had no evidence of acute histoplasmosis. Three of these false positives had rheumatoid arthritis. A fourth had a rising mycoplasma complement fixation titer, and the fifth had a high titer of cold agglutinins. All of these are ass... | 833,267 | [
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Comparison of NADH and NADPH oxidase activities in granules isolated from human polymorphonuclear leukocytes with a fluorometric assay. | A fluormetric method for the determination of pyridine nucleotides has been adapted for use in studying the reduced pyridine nucleotide oxidases in human polymorphonuclear leukocytes. In the presence of strong base the oxidized forms of the pyridine nucleotides form a highly fluorescent product. The small amounts of NA... | 833,275 | [
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A factorial structure of the dimensions of femininity in alcoholic, schizophrenic and normal populations . | The Femininity Study was administered tl 31 alcoholic females, 146 college females, and 152 female schizophrenic patients. The data were factor analyzed: five major factors were identified: (1) heterosexual social role inadaptability; (2) parental role inadaptability; (3) homemaker role inadaptability; (4) general affe... | 833,283 | [
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The WISC as a measure of personality types. | This present analysis attempted to provide evidence for the utility of the WISCto identify a specific group of individuals. Incarcerated juvenile offenders in the 70/79 IQ range were separated according to race and sex and their differential WISC patterns studied. Results focused on the efficiency of each of Wechsler's... | 833,319 | [
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Prior time uncertainty reduction of foreperiod duration in schizophrenia and old age. | Four groups of college students, alcoholics, schizophrenics, and old age Ss judged stimulus durations of .50 and .55 seconds. The stimulus was preceded by a sound that functioned as the warning signal. The foreperiod duration, that is, the interval between the onsets of the warning signal and the stimulus, was variable... | 833,327 | [
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The attitudes of psychiatrists toward etiological theories of schizophrenia. | This study is an analysis of psychiatrists' opinions on the etiology of schizophrenia. A random sample of members of the American Psychiatric Association uncovers a general hesitation on their part to subscribe to any particular etiological theory. Only four theories are viewed as causally related to schizophrenia: soc... | 833,335 | [
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Penfluridol in the maintenance treatment of schizophrenic patients newly discharged from a brief therapy unit. | Penfluridol, a long-acting neuroleptic that can be administered orally once a week, was compared with chlorpromazine in the maintenance treatment of 29 schizophrenic patients newly discharged from a brief therapy unit. The results indicate that penfluridol was of a similar efficacy to chlorpromazine in the treatment of... | 833,344 | [
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Abnormal interhemispheric connections in the visual system of Boston Siamese cats: a physiological study. | In the normal cat most visual fibers in the splenium of the corpus callosum are concerned with a representation of the vertical meridian of the visual field. These fibers for the most part originate from cortical regions forming the border between adjacent architectonic areas, such as the anatomical 17-18 border. Due t... | 833,349 | [
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Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions. | It has been concluded previously that the septohippocampal fibers which project to the rat dentate gyrus extend or branch in the denervated area of the molecular layer following a complete ipsilateral entorhinal lesion. The septohippocampal fibers thus appear to replace some of the perforant fibers which degenerate as ... | 833,359 | [
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Ultrastructure of the feline area postrema. | The morphology of the feline area posterma (AP), a circumventricular organ, has been studied by scanning (SEM) and transmission electron microscopy (TEM). In SEM preparations the boundary of the AP was sharply delineated by the absence of kinocilia. Microvilli were numerous and seemed to be concentrated at the junction... | 833,361 | [
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Medication procedures in a nursing home: abuse of PRN orders. | Nursing home patients often receive more drugs than needed. Drug incompatibilities frequently are found, and PRN orders are apt to be overused. Regulatory agencies require periodic physician review in the hope of eliminating these loose prescribing habits. A study was made of the drugs prescribed for 98 patients in a p... | 833,413 | [
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0.154... |
The relationship between innervation and the cholinesterases of the rat atrioventricular node. | During the first 4 postnatal days, the atrioventricular specialized tissue of the rat contains butyrylcholinesterase alone. The next 7 days are associated with a mixture of both acetyl and butyryl activity, but after the 12th day, acetylcholinesterase is found to predominate largely. It is suggested that this change in... | 833,422 | [
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Radioimmunoassay for murine lactoferrin, a protein marker of myeloid and mammary epithelial secretory cell differentiation. | A radioimmunoassay was developed for murine lactoferrin (LF), a non-heme, iron-binding glycoprotein which appears to be a specific biochemical marker of differentiation in several cell types. Lactoferrin was labeled with 125I by the chloramine-T method to yield a product having 20 muCi/mug protein and an isotope incorp... | 833,425 | [
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Solid phase radioimmunoassay using labelled antibodies: a conceptual framework for designing assays. | A simple theoretical model for the antigen-antibody reaction is presented ans used to evaluate the optimum conditions for designing solid phase radioimmunoassay (RIA) using labelled antibodies. Both theoretical and experimental data are presented, using a wide variety of antigens and their corresponding antibodies. The... | 833,431 | [
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Effects of methotrexate on proliferation of human keratinocytes in vitro. | Normal human keratinocytes, propagated as epithelial outgrowths in vitro, were exposed to different concentrations of methotrexate (MTX) for different periods of time. After a 1-hr exposure, DNA synthesis was inhibited in a reversible manner. No change in the mitotic index was observed. After a 6-hr exposure, both DNA ... | 833,438 | [
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Computer densitometry for angiographic assessment of arterial cholesterol content and gross pathology in human atherosclerosis. | Sequential change studies in human atherosclerosis are desirable in disease regression trials but are now limited by dependence on the occurrence of epidemiologic end-points. Prior radiographic studies have pertained to advanced obstructive atherosclerosis. This is a study of measures applied by computer-generated dens... | 833,474 | [
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A simplified micromethod for assay of reserve bilirubin binding capacity. | The Sephadex gel elution method for assay of the reserve bilirubin binding capacity (RBBC) of the serum of jaundiced newborns has been modified to permit its application on a routine basis in the clinical chemistry laboratory. The volume of sample required has been reduced to 0.2 ml. of serum or less, the time required... | 833,480 | [
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A dipole plus quadrupole lead system for human electrocardiography. | A lead system was constructed to extract dipole and quadrupole components of cardiac sources from surface electrocardiograms (ECGs) recorded at 16 sites. The lead system was based on an analysis of a computerized model of a multipole equivalent cardiac generator in a homogeneous torso. The model was previously determin... | 833,521 | [
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Effects of prindolol on impulse formation and conduction in man. | Electrophysiologic changes produced by intravenous administration of 0.6 mg Prindolol were studied in 16 subjects with normal impulse formation and conduction. The most important changes were: sinus bradycardia, prolongation of atrial refractory periods, depression of intranodal conduction and prolongation of A-V node ... | 833,523 | [
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Evolutionary changes in the electrocardiogram of severe progressive hypothermia. | A patient is reported who developed progressive hypothermia during therapy for adult respiratory distress syndrome. Electrocardiographic changes (sinus bradycardia, prolonged PR interval, prolonged QTc interval, "Osborn waves") were documented and correlated with body temperature. The significance of these changes is d... | 833,527 | [
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Onset of oestrogen-induced prolactin secretion and DNA synthesis by the rat pituitary gland. | The times of onset of oestrogen-induced prolactin secretion and DNA synthesis were studied in the pituitary gland of the male rat. At intervals from 3 to 96 h after injection of 10 mg diethylstilboestrol dipropionate, serum and pituitary prolactin concentrations were measured by radioimmunoassay and pituitary DNA synth... | 833,539 | [
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... |
A comparative study of the effects of certain halogenated benzimidazole ribosides on RNA synthesis, cell proliferation, and interferon production. | 5-(or 6-)Bromo-4,5-(or 5,7-)dichloro-1-beta-D-ribofuranosylbenzimidazole, 5,6-dibromo-1-beta-D-ribofuranosylbenzimidazole, and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole show closely similar structure-activity relationships with respect to inhibition of cellular RNA synthesis, cellular proliferation, and influenz... | 833,544 | [
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Patients with psychogenic pain. | This article describes characteristics of groups of patients with a high probability of having pain complaints on an emotional basis. An approach to patients with psychogenic pain, including management suggestions, is emphasized, with particular reference to the use of extensive history for their identification and the... | 833,561 | [
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Rhodopsin photoproducts and rod sensitivity in the skate retina. | The late photoproducts that result from the isomerization of rhodopsin have been identified in the isolated all-rod retina of the skate by means of rapid spectrophotometry. The sequence in which these intermediates form and decay could be described by a scheme that incorporates two pathways for the degradation of metar... | 833,567 | [
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Genetic determination of methylenomycin synthesis by the SCP1 plasmid of Streptomyces coelicolor A3(2). | Evidence is presented that genes determining the pathway of methylenomycin A synthesis are carried on the SCP1 plasmid. All 16 mutations (mmy) leading to lack of antibiotic synthesis were SCP1-linked. Phenotypic classification, by co-synthesis and other criteria, suggested that they fell into at least five classes. Whe... | 833,570 | [
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0.3040706,
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-0.1424443,
0.2585386,
-0.7880809,
-0.2343131,
-0.4536834,
-0.3168541,
0.01734779,
-0.01647073,
0.6618665,
0.1526468,
-0.1799024,
0... |
Desynchronization of electrical activity in rats induced by deprenyl--an inhibitor of monoamine oxidase B--and relationship with selective increase of dopamine and beta-phenylethylamine. | Electrophysiological and biochemical effects of deprenyl and beta-phenylethylamine were studied in rats. d,1-Deprenyl, 1-deprenyl (4-6 mg/kg) and beta-phenylethylamine (75 mg/kg) induced a desynchronization of ECOG after i.p. administration of drugs. The effects lasted several hours. The biochemical analysis indicate t... | 833,580 | [
0.07625549,
0.1471897,
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0.09790351,
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0.1388818,
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0.3437984,
-0.1826491,
-0... |
Distribution of growth hormone and thyroid-stimulating hormone in cerebrospinal fluid and pathological compartments of the central nervous system. | Human growth hormone (HGH) radio-immunoassay (RIA) was adapted for an accurate measurement of immunoreactive HGH concentrations in the CSF in different cases of hypothalamic-somatotropin dysfunctions. In control subjects (n = 43) mean HGH levels were 0.35 +/- 0.03 ng/ml in CSF and 1.95 +/- 0.2 ng/ml in plasma with a CS... | 833,608 | [
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0.2494376,
0.06136092,
0.1009964,
0.1600222,
0.08058413,
0.09817246,
-0... |
Stimulation of lymphocytes by cholinergic receptor in myasthenia gravis. | Lymphocytes from 13 myasthenic patients were incubated in vitro with membranes enriched in nicotinic cholinergic receptor obtained from Torpedo marmorata electric organ. When autologous serum was present in the incubation medium, the lymphocytes were highly stimulated. In contrast, no stimulation occurred when lymphocy... | 833,615 | [
-0.01378851,
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0.2321857,
0.04625659,
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0.01363,
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-0.03711277,
0.3958406,
0.2721556,
0.02665727,... |
Quantitative evaluation of spinal cord lesions in canine globoid leukodystrophy. | Lesion distribution in the spinal cord was investigated by sampling an average of 26 spinal cord segments in each of ten dogs severely affected by canine globoid leukodystrophy (GLD). GLD lesions were quantified by subdividing spinal white matter into small unit areas and judging the quartile extent of lesion involveme... | 833,619 | [
-0.1061978,
0.1470165,
0.1277229,
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0.309052,
0.02013923,
-0.1875122,
0.2097159,
0.5295754,
0.2243543,
-0.140... |
Antidromic activity in visual radiation during evoked cortical responses. | 1. Antidromic stimulation of the visual radiation of cats has been used to investigate the possibility that some of the activity in principal geniculate cells following an optic tract stimulus is antidromic. Single spikes were selected from two classes of poststimulus activity to condition the antidromic test spike--th... | 833,630 | [
0.06527441,
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0.06732945,
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0.5343267,
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0.1307841,
0.007523518,
0.142222,
0.3354443,
... |
Cortical vein thrombosis in Wegener's granulomatosis. Case report. | A patient with Wegener's granulomatosis is reported in whom a life-threatening cortical vein thrombosis was identified as the process causing acute neurological deterioration. The literature dealing with the neurological and neuropathological manifestations in Wegener's granulomatosis is reviewed. | 833,643 | [
-0.1292046,
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0.2543418,
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0.1156078,
0.3890352,
0.07711532,
... |
Entrapment of median nerve by supracondylar process of the humerus. Case report. | The supracondylar process of the humerus has been described by anatomists and anthropologists in man and lower animals. Infrequently this process may cause compression of the median nerve. We are presenting such a case along with a brief review of the literature. Excision of the bone process led to immediate disappeara... | 833,644 | [
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0.07795084,
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0.3826015,
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0.04003128,
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0.07928643,
0.08634789,
-0.2275394,
-0.1717114,
0.106646,
0.2099023,
... |
Visualization of a bullet track on brain imaging. Case report. | A case is reported in which an intracerebral bullet track was demonstrated by brain imaging, The possible advantages of technetium-99-m localization and the role of brain imaging in gunshot injuries of the head are discussed. | 833,646 | [
-0.495159,
0.1589815,
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0.1690079,
-0.4100117,
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0.3233879,
0.09377683,
0.147939,
0.1128321,
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0.2291353,
0.03759751,
-0.06107175,
0.3797045,
0.07290032,
0.2167661,
0.25... |
Cardiac blood pool imaging over the complete cardiac cycle with a multiformat imager. | A new method of obtaining scintigraphic images of the cardiac blood pool for the study of ventricular wall motion is described. The method, which is based upon an inexpensive modification of a commercial multiformat imaging device, yields a set of serial gated images covering the entire cardiac cycle. These images may ... | 833,661 | [
-0.4964233,
0.6137091,
-0.3974855,
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0.03138546,
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0.0387065,
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0.007499038,
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0.3160262,
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0.247702,
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0.06121764,
-0.2677407,
-0.07362124,
-0.0461868,
0.005936344,
0.4435353,
-0.01411339,
-0.1547... |
Dietary influences on gastric emptying of carbohydrate versus fat in the rat. | The degree to which the rat stomach empties carbohydrate in preference to fat was studied in rats fed a diet or various test means providing carbohydrate and fat in a 3:1 (w/w) ratio. When rats were adlibitum fed a glucose-containing diet, the glucose:fat ratio in gastric contents was consistently lower than in the die... | 833,670 | [
0.06815846,
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0.1827753,
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0.1377558,
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0.1212739,
0.05343175,
0.08089422,
0.02269154,
0.01129649,
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0.3204763,
-0.1007717,
0.1214859,
0.01960363,
0.2396855,
0.03108744,
... |
Variegated color sensations from rod-cone interactions: flicker-fusion experiments. | Multicolored images were produced by the combination of two different color-separation images, one illuminated with 656 nm light and the other illuminated with 500 nm light. Flicker-fusion frequency measurements were used to identify the conditions in which the 500 nm light was below cone threshold. Under those conditi... | 833,697 | [
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0.06133191,
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0.04614791,
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-0.005522933,
0.257733,
-0.2757255,
0.133783,
-0.1545374,
-0.2045192,
-0.3442836,
-0.1001182,
-0.1398905,
-0.5935662,
0.2379988,
-0.06306324,
-0.08131952,
0.03266224,
0.2181783,
0.0524116... |
Avascular transplantation of small bowel in newborn piglets. | Segments of small bowel of newborn piglets were isolated and wrapped in omentum as free autotransplants. After initial necrosis, they regenerate either completely, or at least their muscular layer is restored. As there is a lot of inflammatory reaction in most of the grafts, the conclusion is drawn that either preexist... | 833,714 | [
-0.1960154,
-0.1910748,
-0.1700538,
-0.155567,
0.2609003,
-0.3013735,
-0.2694618,
0.06904623,
0.05789425,
-0.1509164,
0.3047161,
-0.0997287,
-0.0475915,
0.06801622,
-0.5813667,
-0.1300292,
-0.675227,
0.08293413,
-0.2304916,
0.03670641,
0.3427979,
0.2766066,
-0.2119755,
... |
Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6. | The influence of a protective coating of six sunscreening agents (glyceryl p-aminobenzoate, benzocaine, cinoxate, homosalate, n-octyl salicylate, and amyl salicylate) upon the photostability of FD&C Yellow No. 6 used to color coat tablets was studied. The alcohol film, modified sugar-, and film-coating methods were... | 833,722 | [
-0.1703228,
0.2733606,
-0.2147883,
-0.05932866,
0.1750476,
-0.2405329,
-0.210644,
-0.4505472,
0.3416887,
-0.2501346,
0.04325116,
0.3809809,
0.12404,
0.2214843,
-1.067406,
0.05187911,
-0.1042226,
0.3991772,
-0.2526409,
0.2002215,
0.1064425,
0.07867205,
-0.1878897,
-0.164... |
Quantitative determination of benzoic acid and salicyclic acid in ointments by high-pressure liquid chromatography. | Benzoic acid and salicyclic acid in ointments were analyzed quantitatively by reversed-phase high-pressure liquid chromatography. Both benzoic and salicyclic acids can be assayed in combinations directily without interference from each other or the ointment bases. The method is accurate, simple, and rapid. Excellent re... | 833,723 | [
0.03914941,
0.1093291,
0.0184465,
0.0336109,
0.1900977,
0.1202146,
-0.2784777,
-0.09782268,
0.2407045,
-0.2847464,
0.1355403,
0.1309316,
0.06767063,
0.3592153,
-0.2876924,
0.1210018,
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0.07961762,
-0.1748373,
0.174756,
0.2650788,
-0.1536336,
-0.01572848,
-0.08... |
Application of salivary concentration data to pharmacokinetic studies with antipyrine. | The concentrations of antipyrine in plasma and saliva were equivalent in normal volunteers and in patients with acute viral hepatitis following oral doses of antipyrine. Estimates of clearance, volume of distribution, and half-life made from either plasma or saliva samples were not statistically different in these subj... | 833,730 | [
-0.2737339,
-0.1352563,
-0.447793,
-0.1103692,
-0.117271,
-0.1107148,
-0.2329324,
0.07794424,
0.0270474,
-0.1031392,
0.1081075,
0.07461978,
0.1876942,
0.3765207,
-0.256541,
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-0.02642833,
0.1748482,
-0.166721,
0.3761716,
-0.04630803,
0.02079844,
-0.07335696,
0... |
Separation and analysis of delta 9-tetrahydrocannabinol in biological fluids by high-pressure liquid chromatography and GLC. | High-pressure liquid chromatographic (HPLC) systems were developed to separate quantitatively delta 9-tetrahydrocannabinol from heptane-extractable lipoidal and other endogenous substances in biological fluids. These substances interfered with the quantitation by flame-ionization GLC of the unmodified compound and by e... | 833,737 | [
-0.2471368,
0.2307222,
-0.4234838,
-0.2899891,
0.3369615,
-0.3323777,
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0.0004578241,
0.003557066,
0.108192,
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0.06725002,
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0.03027189,
0.393505,
0.1739522,
0.1890488,
0.05875989,
0.08759166,
-0.2855355,
... |
Distribution and pharmacokinetics of triamterene in rats. | The tissue distribution of 14C-triamterene was examined in the fact. After intravenous administration of 14C-triamterene, high concentration ratios between tissues and blood were found in most tissues except the brain, fat, and testes. The maximal concentration of the drug was in the kidneys, liver, heart, lungs, and s... | 833,742 | [
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0.07466759,
-0.2370589,
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0.377073,
-0.1327875,
-0.3298947,
0.2040942,
-0.4240689,
0.03505336,
0.264158,
-0.03894316,
0.2077408,
-0.05763886,
-0.5049066,
0.0308203,
-0.3506772,
0.177049,
0.07024162,
0.3840384,
0.3198859,
0.3118314,
-0.1447354,
-0.2... |
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